Research Topics
| R AdamecSummaryAffiliation: Memorial University of Newfoundland Country: Canada Publications
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Publications
Viral vector induction of CREB expression in the periaqueductal gray induces a predator stress-like pattern of changes in pCREB expression, neuroplasticity, and anxiety in rodentsRobert Adamec
Department of Psychology, Memorial University of Newfoundland, St John s, Newfoundland, Canada A1B 3X9
Neural Plast 2009:904568. 2009....
Activation patterns of cells in selected brain stem nuclei of more and less stress responsive rats in two animal models of PTSD - predator exposure and submersion stressRobert Adamec
Dept of Psychology, Memorial University, St John s, Newfoundland, Canada
Neuropharmacology 62:725-36. 2012..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'...- A comparison of activation patterns of cells in selected prefrontal cortical and amygdala areas of rats which are more or less anxious in response to predator exposure or submersion stressRobert Adamec
Memorial University, St John s, Newfoundland, Canada
Physiol Behav 105:628-38. 2012..The data suggest that preclinical markers of vulnerability/resilience in a given stress paradigm are at best suggestive, and translational value must ultimately be confirmed in humans... 
Relationship of the predatory attack experience to neural plasticity, pCREB expression and neuroendocrine responseRobert E Adamec
Department of Psychology, Memorial University, 232 Elizabeth Ave, St John s, NL, Canada, A1B 3X9
Neurosci Biobehav Rev 30:356-75. 2006....- Protein synthesis and the mechanisms of lasting change in anxiety induced by severe stressRobert Adamec
Department of Psychology, Memorial University, 232 Elizabeth Avenue, St John s, NF, A1B 3X9, Canada
Behav Brain Res 167:270-86. 2006..Since predator stress may model aspects of hyperarousal associated with post traumatic stress disorder (PTSD), implications of these findings for understanding of mechanisms of initiation of the disorder and for treatment are discussed... - Vulnerability to mild predator stress in serotonin transporter knockout miceRobert Adamec
Department of Psychology, Memorial University, 232 Elizabeth Avenue, St John s, Nfld, Canada A1B 3X9
Behav Brain Res 170:126-40. 2006..Findings suggest a role for abnormalities in 5-HT transmission in vulnerability to some of the lasting anxiogenic effects of species relevant stressors and possibly in vulnerability to PTSD... - Lasting anxiogenic effects of feline predator stress in mice: sex differences in vulnerability to stress and predicting severity of anxiogenic response from the stress experienceRobert Adamec
Department of Psychology, Memorial University, 232 Elizabeth Avenue, St John s, NF, Canada, A1B 3X9
Physiol Behav 88:12-29. 2006..Moreover, stressors had no lasting effects on sugar solution consumption. Implications of these findings for modeling PTSD and using transgenic strains of mice to study lasting effects of stress on affect are discussed... - Involvement of noradrenergic and corticoid receptors in the consolidation of the lasting anxiogenic effects of predator stressR Adamec
Department of Psychology, Memorial University, St John s, Newfoundland, Canada A1B 3X9
Behav Brain Res 179:192-207. 2007..Implications of these findings for the study of stress-induced changes in affect including posttraumatic stress disorder (PTSD) are discussed... - The role of the read through variant of acetylcholinesterase in anxiogenic effects of predator stress in miceRobert Adamec
Department of Psychology, Memorial University, 232 Elizabeth Avenue, St John s, NF, A1B 3X9 Canada
Behav Brain Res 189:180-90. 2008.... - Vulnerability to lasting anxiogenic effects of brief exposure to predator stimuli: sex, serotonin and other factors-relevance to PTSDRobert Adamec
Department of Psychology, Memorial University, 232 Elizabeth Avenue, St John s, NF A1B 3X9, Canada
Neurosci Biobehav Rev 32:1287-92. 2008.... - CRF receptor blockade prevents initiation and consolidation of stress effects on affect in the predator stress model of PTSDRobert Adamec
Department of Psychology Memorial University, St John s, NL, Canada
Int J Neuropsychopharmacol 13:747-57. 2010..These data support further research of CRF1 antagonists as potential prophylactic treatments for PTSD... - Long lasting effects of predator stress on pCREB expression in brain regions involved in fearful and anxious behaviorRobert Adamec
Department of Psychology, Memorial University, 232 Elizabeth Avenue St John s, NL, Canada
Behav Brain Res 221:118-33. 2011..Identification of these changes may aid in understanding the neural mechanisms underlying acquired anxiety disorders such as PTSD... - Dendritic morphology of amygdala and hippocampal neurons in more and less predator stress responsive rats and more and less spontaneously anxious handled controlsRobert Adamec
Memorial University, St John s, Newfoundland, Canada, A1B 3X9
Behav Brain Res 226:133-46. 2012..Significance of findings for animal models of anxiety and hyperarousal comorbidities of PTSD are discussed... - Role of NMDA receptors in the lateralized potentiation of amygdala afferent and efferent neural transmission produced by predator stressRobert Adamec
Department of Psychology, Memorial University, St John s, NF, Canada
Physiol Behav 86:75-91. 2005..In contrast, a lateral ACE-PAG pathway is implicated in mediating changes in startle habituation. Finally, consistent with cat and human studies, the right hemisphere appears particularly important in long term response to stress... - Neural circuit changes mediating lasting brain and behavioral response to predator stressRobert E Adamec
Dept of Psychology, Memorial University, 232 Elizabeth Ave, St John s, NL, Canada
Neurosci Biobehav Rev 29:1225-41. 2005..Findings will be discussed within the context of what is known about neural substrates activated by predator odor... - Phosphorylated cyclic AMP response element binding protein expression induced in the periaqueductal gray by predator stress: its relationship to the stress experience, behavior and limbic neural plasticityRobert E Adamec
Department of Psychology, Memorial University, 232 Elizabeth Avenue, A1B 3X9, St John s, Newfoundland, Canada
Prog Neuropsychopharmacol Biol Psychiatry 27:1243-67. 2003..Finally, consistent with cat and human studies, the right hemisphere appears particularly important in long-term response to stress... - Anxiolytic and anxiogenic effects of kindling--role of baseline anxiety and anatomical location of the kindling electrode in response to kindling of the right and left basolateral amygdalaRobert Adamec
Department of Psychology, Memorial University, St John s, Nfld, Canada A1B 3X9
Behav Brain Res 159:73-88. 2005..Present data in the light of past studies suggest both premorbid anxiety state and location of the kindling electrode contribute to the effects of kindling on behavior... - Long-lasting, selective, anxiogenic effects of feline predator stress in miceRobert Adamec
Department of Psychology, Memorial University, 232 Elizabeth Avenue, St John s, NF, Canada A1B 3X9
Physiol Behav 83:401-10. 2004..The significance of these findings for vulnerability to cat predator stress of mice and for the use of predator stress in mice as a model of aspects of posttraumatic stress disorder (PTSD) are discussed... - Effects of systemic injections of vilazodone, a selective serotonin reuptake inhibitor and serotonin 1A receptor agonist, on anxiety induced by predator stress in ratsRobert Adamec
Department of Psychology, Memorial University, 232 Elizabeth Avenue, St John s, NF, A1B 3X9, Canada
Eur J Pharmacol 504:65-77. 2004..Taken together, the data suggest a prophylactic potential for Vilazodone in the treatment of changes in hypervigilance following severe stress... - Neuroplasticity in specific limbic system circuits may mediate specific kindling induced changes in animal affect-implications for understanding anxiety associated with epilepsyR Adamec
Department of Psychology, Memorial University, Nfld, A1B 3X9, St John s, Canada
Neurosci Biobehav Rev 24:705-23. 2000..Taken together, the findings of both studies support the hypothesis that a form of LTP of specific amygdala circuits underlies lasting changes in affect produced by limbic kindling. Clinical implications of these findings are discussed... - Role of NMDA receptors in the syndrome of behavioral changes produced by predator stressJacqueline Blundell
Department of Psychology, Memorial University, St. John's, NF, Canada
Physiol Behav 86:233-43. 2005..Components of this syndrome of behavioral changes likely depend on changes in separable neural substrates initiated in part by NMDA receptors as well as by other neurochemical means... - Rodent anxiety and kindling of the central amygdala and nucleus basalisR Adamec
Department of Psychology, Memorial University, A1B 3X9, St John s, Newfoundland, Canada
Physiol Behav 70:177-87. 2000..These findings add to a growing body of evidence that suggests that subtle differences in location of a kindled focus within the rat amygdala lead to different behavioral outcomes... - Effects of baseline anxiety on response to kindling of the right medial amygdalaR Adamec
Dept of Psychology, Memorial University, St John s, Nfld, A1B 3X9, Newfoundland, Canada
Physiol Behav 70:67-80. 2000..The fact that previous studies have not taken them into account perhaps explains inconsistencies in the reported behavioral effects of kindling on behavior in rodents... - Elevated pCREB in the PAG after exposure to the elevated plus maze in rats previously exposed to a catJacqueline Blundell
Department of Psychology, Memorial University of Newfoundland and Labrador, St John s, Nfld, Canada A1B 3X9
Behav Brain Res 175:285-95. 2006..If what happens in animals also occurs in humans, the findings of this study suggest that neural mechanisms of prior traumatic stress may interact with subsequent stress to reinforce psychopathology... - Prophylactic and therapeutic effects of acute systemic injections of EMD 281014, a selective serotonin 2A receptor antagonist on anxiety induced by predator stress in ratsRobert Adamec
Department of Psychology, Memorial University, 232 Elizabeth Avenue, St John s, NF, A1B 3X9, Canada
Eur J Pharmacol 504:79-96. 2004..Findings implicate 5-HT(2A) receptors in initiation of some but not all lasting changes in anxiety-like behavior following predator stress. Potential clinical significance of findings are discussed... - Does long term potentiation in periacqueductal gray (PAG) mediate lasting changes in rodent anxiety-like behavior (ALB) produced by predator stress?--Effects of low frequency stimulation (LFS) of PAG on place preference and changes in ALB produced by predR Adamec
Department of Psychology, Memorial University, St John s, Nfld, Canada A1B 3X9
Behav Brain Res 120:111-35. 2001..Biobevav. Rev. 21(6) (1997) 755; Adamec, J. Psychopharmacol. 2000 (in press); Adamec, J. Psychopharmacol. 2000 (in press); Adamec, J. Psychopharmacol. 12(2) (1998) 129; Adamec, J. Psychopharmacol. 12(13) (1998) 227]... - Anxiolytic effects of kindling role of anatomical location of the kindling electrode in response to kindling of the right basolateral amygdalaRobert Adamec
Department of Psychology, Memorial University, St John s, Nfld, Canada A1B 3X9
Brain Res 1024:44-58. 2004.... - Expression of egr-1 (zif268) mRNA in select fear-related brain regions following exposure to a predatorJeffrey B Rosen
Department of Psychology, University of Delaware, 108 Wolf Hall, Newark, DE 19716, USA
Behav Brain Res 162:279-88. 2005..The results are discussed in a context of differences and similarities in neural circuitry for conditioned and unconditioned fear... - Stress effects on limbic function and behaviorRobert E Adamec
Department of Psychology, Memorial University, 232 Elisabeth Avenue, A1B 3X9, St. John's, NF, Canada
Prog Neuropsychopharmacol Biol Psychiatry 27:1173-5. 2003