R Adamec

Summary

Affiliation: Memorial University of Newfoundland
Country: Canada

Publications

  1. pmc Viral vector induction of CREB expression in the periaqueductal gray induces a predator stress-like pattern of changes in pCREB expression, neuroplasticity, and anxiety in rodents
    Robert Adamec
    Department of Psychology, Memorial University of Newfoundland, St John s, Newfoundland, Canada A1B 3X9
    Neural Plast 2009:904568. 2009
  2. doi request reprint Activation patterns of cells in selected brain stem nuclei of more and less stress responsive rats in two animal models of PTSD - predator exposure and submersion stress
    Robert Adamec
    Dept of Psychology, Memorial University, St John s, Newfoundland, Canada
    Neuropharmacology 62:725-36. 2012
  3. doi request reprint A comparison of activation patterns of cells in selected prefrontal cortical and amygdala areas of rats which are more or less anxious in response to predator exposure or submersion stress
    Robert Adamec
    Memorial University, St John s, Newfoundland, Canada
    Physiol Behav 105:628-38. 2012
  4. ncbi request reprint Protein synthesis and the mechanisms of lasting change in anxiety induced by severe stress
    Robert Adamec
    Department of Psychology, Memorial University, 232 Elizabeth Avenue, St John s, NF, A1B 3X9, Canada
    Behav Brain Res 167:270-86. 2006
  5. ncbi request reprint Vulnerability to mild predator stress in serotonin transporter knockout mice
    Robert Adamec
    Department of Psychology, Memorial University, 232 Elizabeth Avenue, St John s, Nfld, Canada A1B 3X9
    Behav Brain Res 170:126-40. 2006
  6. ncbi request reprint Lasting anxiogenic effects of feline predator stress in mice: sex differences in vulnerability to stress and predicting severity of anxiogenic response from the stress experience
    Robert Adamec
    Department of Psychology, Memorial University, 232 Elizabeth Avenue, St John s, NF, Canada, A1B 3X9
    Physiol Behav 88:12-29. 2006
  7. ncbi request reprint Involvement of noradrenergic and corticoid receptors in the consolidation of the lasting anxiogenic effects of predator stress
    R Adamec
    Department of Psychology, Memorial University, St John s, Newfoundland, Canada A1B 3X9
    Behav Brain Res 179:192-207. 2007
  8. doi request reprint The role of the read through variant of acetylcholinesterase in anxiogenic effects of predator stress in mice
    Robert Adamec
    Department of Psychology, Memorial University, 232 Elizabeth Avenue, St John s, NF, A1B 3X9 Canada
    Behav Brain Res 189:180-90. 2008
  9. pmc Vulnerability to lasting anxiogenic effects of brief exposure to predator stimuli: sex, serotonin and other factors-relevance to PTSD
    Robert Adamec
    Department of Psychology, Memorial University, 232 Elizabeth Avenue, St John s, NF A1B 3X9, Canada
    Neurosci Biobehav Rev 32:1287-92. 2008
  10. pmc CRF receptor blockade prevents initiation and consolidation of stress effects on affect in the predator stress model of PTSD
    Robert Adamec
    Department of Psychology Memorial University, St John s, NL, Canada
    Int J Neuropsychopharmacol 13:747-57. 2010

Detail Information

Publications30

  1. pmc Viral vector induction of CREB expression in the periaqueductal gray induces a predator stress-like pattern of changes in pCREB expression, neuroplasticity, and anxiety in rodents
    Robert Adamec
    Department of Psychology, Memorial University of Newfoundland, St John s, Newfoundland, Canada A1B 3X9
    Neural Plast 2009:904568. 2009
    ....
  2. doi request reprint Activation patterns of cells in selected brain stem nuclei of more and less stress responsive rats in two animal models of PTSD - predator exposure and submersion stress
    Robert Adamec
    Dept of Psychology, Memorial University, St John s, Newfoundland, Canada
    Neuropharmacology 62:725-36. 2012
    ..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'...
  3. doi request reprint A comparison of activation patterns of cells in selected prefrontal cortical and amygdala areas of rats which are more or less anxious in response to predator exposure or submersion stress
    Robert Adamec
    Memorial University, St John s, Newfoundland, Canada
    Physiol Behav 105:628-38. 2012
    ..The data suggest that preclinical markers of vulnerability/resilience in a given stress paradigm are at best suggestive, and translational value must ultimately be confirmed in humans...
  4. ncbi request reprint Protein synthesis and the mechanisms of lasting change in anxiety induced by severe stress
    Robert Adamec
    Department of Psychology, Memorial University, 232 Elizabeth Avenue, St John s, NF, A1B 3X9, Canada
    Behav Brain Res 167:270-86. 2006
    ..Since predator stress may model aspects of hyperarousal associated with post traumatic stress disorder (PTSD), implications of these findings for understanding of mechanisms of initiation of the disorder and for treatment are discussed...
  5. ncbi request reprint Vulnerability to mild predator stress in serotonin transporter knockout mice
    Robert Adamec
    Department of Psychology, Memorial University, 232 Elizabeth Avenue, St John s, Nfld, Canada A1B 3X9
    Behav Brain Res 170:126-40. 2006
    ..Findings suggest a role for abnormalities in 5-HT transmission in vulnerability to some of the lasting anxiogenic effects of species relevant stressors and possibly in vulnerability to PTSD...
  6. ncbi request reprint Lasting anxiogenic effects of feline predator stress in mice: sex differences in vulnerability to stress and predicting severity of anxiogenic response from the stress experience
    Robert Adamec
    Department of Psychology, Memorial University, 232 Elizabeth Avenue, St John s, NF, Canada, A1B 3X9
    Physiol Behav 88:12-29. 2006
    ..Moreover, stressors had no lasting effects on sugar solution consumption. Implications of these findings for modeling PTSD and using transgenic strains of mice to study lasting effects of stress on affect are discussed...
  7. ncbi request reprint Involvement of noradrenergic and corticoid receptors in the consolidation of the lasting anxiogenic effects of predator stress
    R Adamec
    Department of Psychology, Memorial University, St John s, Newfoundland, Canada A1B 3X9
    Behav Brain Res 179:192-207. 2007
    ..Implications of these findings for the study of stress-induced changes in affect including posttraumatic stress disorder (PTSD) are discussed...
  8. doi request reprint The role of the read through variant of acetylcholinesterase in anxiogenic effects of predator stress in mice
    Robert Adamec
    Department of Psychology, Memorial University, 232 Elizabeth Avenue, St John s, NF, A1B 3X9 Canada
    Behav Brain Res 189:180-90. 2008
    ....
  9. pmc Vulnerability to lasting anxiogenic effects of brief exposure to predator stimuli: sex, serotonin and other factors-relevance to PTSD
    Robert Adamec
    Department of Psychology, Memorial University, 232 Elizabeth Avenue, St John s, NF A1B 3X9, Canada
    Neurosci Biobehav Rev 32:1287-92. 2008
    ....
  10. pmc CRF receptor blockade prevents initiation and consolidation of stress effects on affect in the predator stress model of PTSD
    Robert Adamec
    Department of Psychology Memorial University, St John s, NL, Canada
    Int J Neuropsychopharmacol 13:747-57. 2010
    ..These data support further research of CRF1 antagonists as potential prophylactic treatments for PTSD...
  11. doi request reprint Long lasting effects of predator stress on pCREB expression in brain regions involved in fearful and anxious behavior
    Robert Adamec
    Department of Psychology, Memorial University, 232 Elizabeth Avenue St John s, NL, Canada
    Behav Brain Res 221:118-33. 2011
    ..Identification of these changes may aid in understanding the neural mechanisms underlying acquired anxiety disorders such as PTSD...
  12. pmc Dendritic morphology of amygdala and hippocampal neurons in more and less predator stress responsive rats and more and less spontaneously anxious handled controls
    Robert Adamec
    Memorial University, St John s, Newfoundland, Canada, A1B 3X9
    Behav Brain Res 226:133-46. 2012
    ..Significance of findings for animal models of anxiety and hyperarousal comorbidities of PTSD are discussed...
  13. ncbi request reprint Relationship of the predatory attack experience to neural plasticity, pCREB expression and neuroendocrine response
    Robert E Adamec
    Department of Psychology, Memorial University, 232 Elizabeth Ave, St John s, NL, Canada, A1B 3X9
    Neurosci Biobehav Rev 30:356-75. 2006
    ....
  14. ncbi request reprint Role of NMDA receptors in the lateralized potentiation of amygdala afferent and efferent neural transmission produced by predator stress
    Robert Adamec
    Department of Psychology, Memorial University, St John s, NF, Canada
    Physiol Behav 86:75-91. 2005
    ..In contrast, a lateral ACE-PAG pathway is implicated in mediating changes in startle habituation. Finally, consistent with cat and human studies, the right hemisphere appears particularly important in long term response to stress...
  15. ncbi request reprint Effects of systemic injections of vilazodone, a selective serotonin reuptake inhibitor and serotonin 1A receptor agonist, on anxiety induced by predator stress in rats
    Robert Adamec
    Department of Psychology, Memorial University, 232 Elizabeth Avenue, St John s, NF, A1B 3X9, Canada
    Eur J Pharmacol 504:65-77. 2004
    ..Taken together, the data suggest a prophylactic potential for Vilazodone in the treatment of changes in hypervigilance following severe stress...
  16. ncbi request reprint Neural circuit changes mediating lasting brain and behavioral response to predator stress
    Robert E Adamec
    Dept of Psychology, Memorial University, 232 Elizabeth Ave, St John s, NL, Canada
    Neurosci Biobehav Rev 29:1225-41. 2005
    ..Findings will be discussed within the context of what is known about neural substrates activated by predator odor...
  17. ncbi request reprint Phosphorylated cyclic AMP response element binding protein expression induced in the periaqueductal gray by predator stress: its relationship to the stress experience, behavior and limbic neural plasticity
    Robert E Adamec
    Department of Psychology, Memorial University, 232 Elizabeth Avenue, A1B 3X9, St John s, Newfoundland, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 27:1243-67. 2003
    ..Finally, consistent with cat and human studies, the right hemisphere appears particularly important in long-term response to stress...
  18. ncbi request reprint Anxiolytic and anxiogenic effects of kindling--role of baseline anxiety and anatomical location of the kindling electrode in response to kindling of the right and left basolateral amygdala
    Robert Adamec
    Department of Psychology, Memorial University, St John s, Nfld, Canada A1B 3X9
    Behav Brain Res 159:73-88. 2005
    ..Present data in the light of past studies suggest both premorbid anxiety state and location of the kindling electrode contribute to the effects of kindling on behavior...
  19. ncbi request reprint Long-lasting, selective, anxiogenic effects of feline predator stress in mice
    Robert Adamec
    Department of Psychology, Memorial University, 232 Elizabeth Avenue, St John s, NF, Canada A1B 3X9
    Physiol Behav 83:401-10. 2004
    ..The significance of these findings for vulnerability to cat predator stress of mice and for the use of predator stress in mice as a model of aspects of posttraumatic stress disorder (PTSD) are discussed...
  20. ncbi request reprint Neuroplasticity in specific limbic system circuits may mediate specific kindling induced changes in animal affect-implications for understanding anxiety associated with epilepsy
    R Adamec
    Department of Psychology, Memorial University, Nfld, A1B 3X9, St John s, Canada
    Neurosci Biobehav Rev 24:705-23. 2000
    ..Taken together, the findings of both studies support the hypothesis that a form of LTP of specific amygdala circuits underlies lasting changes in affect produced by limbic kindling. Clinical implications of these findings are discussed...
  21. ncbi request reprint Role of NMDA receptors in the syndrome of behavioral changes produced by predator stress
    Jacqueline Blundell
    Department of Psychology, Memorial University, St John s, NF, Canada
    Physiol Behav 86:233-43. 2005
    ..Components of this syndrome of behavioral changes likely depend on changes in separable neural substrates initiated in part by NMDA receptors as well as by other neurochemical means...
  22. ncbi request reprint Rodent anxiety and kindling of the central amygdala and nucleus basalis
    R Adamec
    Department of Psychology, Memorial University, A1B 3X9, St John s, Newfoundland, Canada
    Physiol Behav 70:177-87. 2000
    ..These findings add to a growing body of evidence that suggests that subtle differences in location of a kindled focus within the rat amygdala lead to different behavioral outcomes...
  23. ncbi request reprint Effects of baseline anxiety on response to kindling of the right medial amygdala
    R Adamec
    Dept of Psychology, Memorial University, St John s, Nfld, A1B 3X9, Newfoundland, Canada
    Physiol Behav 70:67-80. 2000
    ..The fact that previous studies have not taken them into account perhaps explains inconsistencies in the reported behavioral effects of kindling on behavior in rodents...
  24. ncbi request reprint Prophylactic and therapeutic effects of acute systemic injections of EMD 281014, a selective serotonin 2A receptor antagonist on anxiety induced by predator stress in rats
    Robert Adamec
    Department of Psychology, Memorial University, 232 Elizabeth Avenue, St John s, NF, A1B 3X9, Canada
    Eur J Pharmacol 504:79-96. 2004
    ..Findings implicate 5-HT(2A) receptors in initiation of some but not all lasting changes in anxiety-like behavior following predator stress. Potential clinical significance of findings are discussed...
  25. ncbi request reprint Elevated pCREB in the PAG after exposure to the elevated plus maze in rats previously exposed to a cat
    Jacqueline Blundell
    Department of Psychology, Memorial University of Newfoundland and Labrador, St John s, Nfld, Canada A1B 3X9
    Behav Brain Res 175:285-95. 2006
    ..If what happens in animals also occurs in humans, the findings of this study suggest that neural mechanisms of prior traumatic stress may interact with subsequent stress to reinforce psychopathology...
  26. ncbi request reprint Does long term potentiation in periacqueductal gray (PAG) mediate lasting changes in rodent anxiety-like behavior (ALB) produced by predator stress?--Effects of low frequency stimulation (LFS) of PAG on place preference and changes in ALB produced by pred
    R Adamec
    Department of Psychology, Memorial University, St John s, Nfld, Canada A1B 3X9
    Behav Brain Res 120:111-35. 2001
    ..Biobevav. Rev. 21(6) (1997) 755; Adamec, J. Psychopharmacol. 2000 (in press); Adamec, J. Psychopharmacol. 2000 (in press); Adamec, J. Psychopharmacol. 12(2) (1998) 129; Adamec, J. Psychopharmacol. 12(13) (1998) 227]...
  27. ncbi request reprint Anxiolytic effects of kindling role of anatomical location of the kindling electrode in response to kindling of the right basolateral amygdala
    Robert Adamec
    Department of Psychology, Memorial University, St John s, Nfld, Canada A1B 3X9
    Brain Res 1024:44-58. 2004
    ....
  28. ncbi request reprint Expression of egr-1 (zif268) mRNA in select fear-related brain regions following exposure to a predator
    Jeffrey B Rosen
    Department of Psychology, University of Delaware, 108 Wolf Hall, Newark, DE 19716, USA
    Behav Brain Res 162:279-88. 2005
    ..The results are discussed in a context of differences and similarities in neural circuitry for conditioned and unconditioned fear...
  29. ncbi request reprint Stress effects on limbic function and behavior
    Robert E Adamec
    Department of Psychology, Memorial University, 232 Elisabeth Avenue, A1B 3X9, St John s, NF, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 27:1173-5. 2003