Sylvain Meloche

Summary

Country: Canada

Publications

  1. doi request reprint F-box proteins elongate translation during stress recovery
    Sylvain Meloche
    Institute for Research in Immunology and Cancer, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    Sci Signal 5:pe25. 2012
  2. ncbi request reprint The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition
    S Meloche
    Departments of Pharmacology and Molecular Biology, Institut de Recherche en Immunologie et Cancérologie, Universite de Montreal, Montreal, Quebec, Canada
    Oncogene 26:3227-39. 2007
  3. ncbi request reprint Erk2 signaling and early embryo stem cell self-renewal
    Sylvain Meloche
    Institut de recherche en immunovirologie et cancérologie, Universite de Montreal, Montreal, Quebec Canada
    Cell Cycle 3:241-3. 2004
  4. pmc Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation
    Philippe Coulombe
    Institut de Recherches Cliniques de Montreal, Universite de Montreal, Montreal, Quebec H2W 1R7, Canada
    Mol Cell Biol 23:4542-58. 2003
  5. pmc Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association
    Jean François Clément
    Faculte de Pharmacie, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec, Canada
    J Virol 82:3984-96. 2008
  6. doi request reprint Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5
    Paul Déléris
    Institut de Recherche en Immunologie et Cancérologie, Montreal, Quebec, Canada
    J Cell Physiol 217:778-88. 2008
  7. ncbi request reprint Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2
    Christel Boutonnet
    Institut de Recherche en Immunologie et Cancérologie, Universite de Montreal, Montreal, QC, Canada
    Cell Cycle 9:975-9. 2010
  8. pmc p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2
    Geneviève Rodier
    Institut de recherche en immunovirologie et cancérologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Cell Biol 168:55-66. 2005
  9. doi request reprint Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation
    Stéphanie Duhamel
    Program of Molecular Biology, Institut de Recherche en Immunologie et Cancérologie, Universite de Montreal, Montreal, Quebec, Canada
    Cancer Res 72:626-35. 2012
  10. pmc Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation
    Laure Voisin
    Institut de Recherche en Immunologie et Cancérologie, Universite de Montreal, P O Box 6128, Station Centre Ville, Montreal, Quebec H3C 3J7, Canada
    Mol Cell Biol 30:2918-32. 2010

Collaborators

Detail Information

Publications57

  1. doi request reprint F-box proteins elongate translation during stress recovery
    Sylvain Meloche
    Institute for Research in Immunology and Cancer, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    Sci Signal 5:pe25. 2012
    ..These findings establish an important link between DNA damage signaling and the regulation of translation elongation...
  2. ncbi request reprint The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition
    S Meloche
    Departments of Pharmacology and Molecular Biology, Institut de Recherche en Immunologie et Cancérologie, Universite de Montreal, Montreal, Quebec, Canada
    Oncogene 26:3227-39. 2007
    ..In this review, we discuss the mechanisms by which activated ERK1/ERK2 regulate growth and cell cycle progression of mammalian somatic cells. We also highlight the findings obtained from gene disruption studies...
  3. ncbi request reprint Erk2 signaling and early embryo stem cell self-renewal
    Sylvain Meloche
    Institut de recherche en immunovirologie et cancérologie, Universite de Montreal, Montreal, Quebec Canada
    Cell Cycle 3:241-3. 2004
    ..Thus, signaling by the ERK1/2 MAP kinase pathway appears to be critical for the regulation of self-renewal and propagation of early embryo stem cell populations...
  4. pmc Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation
    Philippe Coulombe
    Institut de Recherches Cliniques de Montreal, Universite de Montreal, Montreal, Quebec H2W 1R7, Canada
    Mol Cell Biol 23:4542-58. 2003
    ..Interestingly, we found that expression of stabilized forms of ERK3 causes G(1) arrest in NIH 3T3 cells. We propose that ERK3 biological activity is regulated by its cellular abundance through the control of protein stability...
  5. pmc Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association
    Jean François Clément
    Faculte de Pharmacie, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec, Canada
    J Virol 82:3984-96. 2008
    ..Importantly, our study establishes a molecular link between the role of serine 339 in IRF-3 homodimerization, CBP association, and its destabilization...
  6. doi request reprint Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5
    Paul Déléris
    Institut de Recherche en Immunologie et Cancérologie, Montreal, Quebec, Canada
    J Cell Physiol 217:778-88. 2008
    ..Our results demonstrate the importance of activation loop phosphorylation in the regulation of ERK3/ERK4 function and highlight differences in the regulation of atypical MAP kinases as compared to classical family members...
  7. ncbi request reprint Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2
    Christel Boutonnet
    Institut de Recherche en Immunologie et Cancérologie, Universite de Montreal, Montreal, QC, Canada
    Cell Cycle 9:975-9. 2010
    ..We show here that phosphorylation of Ser72 does not control Skp2 binding to Skp1 and Cul1, has no influence on SCF(Skp2) ubiquitin ligase activity, and does not affect the subcellular localization of Skp2 in a panel of cell lines...
  8. pmc p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2
    Geneviève Rodier
    Institut de recherche en immunovirologie et cancérologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Cell Biol 168:55-66. 2005
    ..We propose that p107, in addition to its interaction with E2F, inhibits cell proliferation through the control of Skp2 expression and the resulting stabilization of p27...
  9. doi request reprint Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation
    Stéphanie Duhamel
    Program of Molecular Biology, Institut de Recherche en Immunologie et Cancérologie, Universite de Montreal, Montreal, Quebec, Canada
    Cancer Res 72:626-35. 2012
    ..Taken together, our findings indicate that Ras-induced downregulation of Sef is an early oncogenic event that contributes to genetic instability and tumor progression by sustaining nuclear ERK1/2 signaling...
  10. pmc Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation
    Laure Voisin
    Institut de Recherche en Immunologie et Cancérologie, Universite de Montreal, P O Box 6128, Station Centre Ville, Montreal, Quebec H3C 3J7, Canada
    Mol Cell Biol 30:2918-32. 2010
    ..Together, our findings provide compelling genetic evidence for a redundant role of ERK1 and ERK2 in promoting cell proliferation...
  11. doi request reprint Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia
    Matthias Trost
    Institute for Research in Immunology and Cancer, Universite de Montreal, Montreal, QC, Canada
    Blood 120:e17-27. 2012
    ....
  12. pmc N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome
    Philippe Coulombe
    Institut de recherche en immunovirologie et cancérologie, Department of Molecular Biology, Universite de Montreal, Quebec, Canada
    Mol Cell Biol 24:6140-50. 2004
    ..Our results suggests that N-terminal ubiquitination is a more prevalent modification than originally recognized...
  13. pmc Sustained in vitro trigger of self-renewal divisions in Hoxb4hiPbx1(10) hematopoietic stem cells
    Sonia Cellot
    Laboratory of Molecular Genetics of Stem Cells, Institute for Research in Immunology and Cancer IRIC, Montreal, QC, Canada
    Exp Hematol 35:802-16. 2007
    ..We thus put forward this strategy as an efficient in vitro HSC expansion tool, enabling a further step into the avenue of self-renewal molecular effectors...
  14. pmc Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway
    Paul Déléris
    Institut de Recherche en Immunologie et Cancérologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 286:6470-8. 2011
    ..Our results reveal that group I PAKs act as upstream activators of ERK3 and ERK4 and unravel a novel PAK-ERK3/ERK4-MK5 signaling pathway...
  15. pmc E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells
    Jalila Chagraoui
    Laboratory of Molecular Genetics of Hematopoietic Stem Cells, Institut de Recherche en Immunologie et Cancérologie IRIC, CP 6128 Succursale Centre Ville, Montreal, Quebec, Canada
    Genes Dev 20:2110-20. 2006
    ..Together, these findings identify E4F1 as a key modulator of BMI1 activity in primitive hematopoietic cells...
  16. pmc Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors
    Laure Voisin
    Institut de Recherche en Immunologie et Cancérologie, Montreal, Quebec, Canada
    BMC Cancer 8:337. 2008
    ..However, the exact contribution of MEK1 and MEK2 to the pathogenesis of colorectal cancer remains to be established...
  17. doi request reprint Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions
    Mathieu Courcelles
    Institute for Research in Immunology and Cancer, Universite de Montreal, Montreal, Quebec, Canada
    Mol Syst Biol 9:669. 2013
    ..Our study expands the spectrum of cellular functions controlled by ERK1/2 kinases...
  18. pmc Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase
    Geneviève Rodier
    Institut de Recherche en Immunologie et Cancérologie, Universite de Montreal, Montreal, Quebec, Canada
    EMBO J 27:679-91. 2008
    ..Thus, our results reveal that reversible phosphorylation plays a key role in the timing of Skp2 expression in the cell cycle...
  19. pmc Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity
    Wendy J van Zuylen
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec Canada
    PLoS Pathog 8:e1002747. 2012
    ....
  20. pmc Phosphorylation of the MAPKKK regulator Ste50p in Saccharomyces cerevisiae: a casein kinase I phosphorylation site is required for proper mating function
    Cunle Wu
    Genetics Group, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada H4P 2R2
    Eukaryot Cell 2:949-61. 2003
    ..However, this phosphorylation does not seem to have a detectable role in modulating the high-osmolarity glycerol synthesis pathway...
  21. ncbi request reprint Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression
    Catherine Julien
    Institut de Recherches Cliniques de Montreal, Universite de Montreal, 110 Pine Avenue West, Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 278:42615-24. 2003
    ..Our results suggest that nucleocytoplasmic shuttling of ERK3 is required for its negative regulatory effect on cell cycle progression...
  22. ncbi request reprint Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation
    Annie Bibeau-Poirier
    Faculty of Pharmacy, University of Montreal, Montreal, Canada
    J Immunol 177:5059-67. 2006
    ....
  23. pmc An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development
    Marc K Saba-El-Leil
    Institut de Recherches Cliniques de Montréal and Department of Pharmacology, Universite de Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    EMBO Rep 4:964-8. 2003
    ..The inability of Erk1 to compensate for Erk2 function suggests a specific function for Erk2 in normal trophoblast development in the mouse, probably in regulating the proliferation of polar trophectoderm cells...
  24. pmc Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality
    Sonia Klinger
    Institut de Recherche en Immunologie et Cancérologie and Departments of Pharmacology and Molecular Biology, Universite de Montreal, Montreal, Quebec, Canada
    Proc Natl Acad Sci U S A 106:16710-5. 2009
    ..Our findings reveal a critical role for Erk3 in the establishment of fetal growth potential and pulmonary function in the mouse...
  25. ncbi request reprint Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals
    Donglei Zhang
    Department of Surgery, McGill University Health Center, The Royal Victoria Hospital, Room H6 25, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    J Biol Chem 279:19683-90. 2004
    ..The outcome of IGF-IR (the receptor for IGF-I) activation may ultimately depend on factors, such as ligand bioavailability, that can shift the balance preferentially toward one pathway or the other...
  26. doi request reprint Liver fibrosis protects mice from acute hepatocellular injury
    Eric Bourbonnais
    Laboratoire d Hépatologie Cellulaire du Centre de Recherche du CHUM Hôpital Saint Luc, Montreal, Quebec, Canada
    Gastroenterology 142:130-139.e4. 2012
    ....
  27. ncbi request reprint Role of p44/p42 MAP kinase in the age-dependent increase in vascular smooth muscle cell proliferation and neointimal formation
    Giuseppa Gennaro
    Department of Cardiovascular Research, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 23:204-10. 2003
    ..In this study, we investigated the role of mitogen-activated protein kinases (MAPKs) on VSMC proliferation and neointimal formation in the context of aging...
  28. pmc Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation
    Xavier Deschênes-Simard
    Departement de Biochimie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    Genes Dev 27:900-15. 2013
    ..We thus identified a mechanism that links aberrant activation of growth signaling pathways and short telomeres to protein degradation and cellular senescence...
  29. ncbi request reprint Cyclic AMP induces morphological changes of vascular smooth muscle cells by inhibiting a Rac-dependent signaling pathway
    Stephane Pelletier
    Institut de recherche en immunovirologie et cancérologie, Universite de Montreal, Montreal, Quebec, Canada
    J Cell Physiol 204:412-22. 2005
    ..We further show that activated Rac1 containing the F37A effector loop substitution fails to rescue the cAMP phenotype. Our results suggest that cAMP modulates the morphology of VSMCs by inhibiting a Rac-dependent signaling pathway...
  30. pmc The eIF4E RNA regulon promotes the Akt signaling pathway
    Biljana Culjkovic
    Institute for Research in Immunology and Cancer, Universite de Montreal, Montreal, Québec H4M 1J6, Canada
    J Cell Biol 181:51-63. 2008
    ..In summary, eIF4E coordinately regulates gene expression to potentiate Akt activation, an activity required for apoptotic rescue...
  31. doi request reprint C-terminal domain phosphorylation of ERK3 controlled by Cdk1 and Cdc14 regulates its stability in mitosis
    Pierre Luc Tanguay
    Institut de Recherche en Immunologie et Cancérologie, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    Biochem J 428:103-11. 2010
    ..The results of the present study identify a novel regulatory mechanism of ERK3 that operates in a cell-cycle-dependent manner...
  32. pmc Targeted inactivation of Mapk4 in mice reveals specific nonredundant functions of Erk3/Erk4 subfamily mitogen-activated protein kinases
    Justine Rousseau
    Institut de Recherche en Immunologie et Cancérologie, Universite de Montreal, Montreal, Quebec, Canada
    Mol Cell Biol 30:5752-63. 2010
    ..Our analysis indicates that the MAP kinase Erk4 is dispensable for mouse embryonic development and reveals that Erk3 and Erk4 have acquired specialized functions through evolutionary diversification...
  33. ncbi request reprint EN2 is a candidate oncogene in human breast cancer
    Nicole L Martin
    Laboratory of Molecular Genetics of Hematopoietic Stem Cells, Institut de Recherche en Immunologie et Cancérologie, CP 6128, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Oncogene 24:6890-901. 2005
    ..RNA interference studies suggest that EN2 expression is required for the maintenance of the transformed phenotype of a human breast tumor cell line...
  34. doi request reprint ProteoConnections: a bioinformatics platform to facilitate proteome and phosphoproteome analyses
    Mathieu Courcelles
    IRIC, Institute of Research in Immunology and Cancer, Universite de Montreal, Montreal, Canada Department of Biochemistry, Universite de Montreal, Montreal, Canada
    Proteomics 11:2654-71. 2011
    ....
  35. pmc Artifactual sulfation of silver-stained proteins: implications for the assignment of phosphorylation and sulfation sites
    Marlene Gharib
    Institute of Research in Immunology and Cancer IRIC, Universite de Montreal, Montreal, Quebec, Canada
    Mol Cell Proteomics 8:506-18. 2009
    ..02%, which is typically used for silver staining. The significance of this artifact is discussed in the broader context of sulfation and phosphorylation site identification from in vivo and in vitro experiments...
  36. ncbi request reprint Expression of angiotensin type II receptor downregulates Cdk4 synthesis and inhibits cell-cycle progression
    Bruno Gingras
    Institut de Recherches Cliniques de Montréal and Department of Pharmacology, Universite de Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    Oncogene 22:2633-42. 2003
    ..These findings suggest that the growth-inhibitory effects of the AT(2) receptor are attributable in part to its spontaneous inhibitory action on the cell cycle machinery...
  37. ncbi request reprint Chromosome mapping of the human genes encoding the MAP kinase kinase MEK1 (MAP2K1) to 15q21 and MEK2 (MAP2K2) to 7q32
    S Meloche
    Research Centre, Centre hospitalier de l Université de Montréal and Department of Pharmacology, University of Montreal, Quebec, Canada
    Cytogenet Cell Genet 88:249-52. 2000
    ..We also present evidence for the presence of a MEK1 pseudogene on chromosome 8p21. The MEK2 gene (MAP2K2) was mapped to chromosome 7q32 by fluorescence in situ hybridization and YAC clone analysis...
  38. ncbi request reprint p38 MAP kinase pathway regulates angiotensin II-induced contraction of rat vascular smooth muscle
    S Meloche
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, and Department of Pharmacology, University of Montreal, Montreal, Quebec, Canada H2W 1T8
    Am J Physiol Heart Circ Physiol 279:H741-51. 2000
    ..These results suggest that the p38 MAP kinase pathway selectively modulates the vasoconstrictor action of ANG II in vascular smooth muscle...
  39. ncbi request reprint Atypical mitogen-activated protein kinases: structure, regulation and functions
    Phillipe Coulombe
    Institut de Recherche en Immunologie et Cancérologie and Department of Pharmacology, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    Biochim Biophys Acta 1773:1376-87. 2007
    ..Atypical MAP kinases include ERK3/ERK4, NLK and ERK7. Much less is known about the regulation, substrate specificity and physiological functions of atypical MAP kinases...
  40. doi request reprint Interpreting neonatal lethal phenotypes in mouse mutants: insights into gene function and human diseases
    Benjamin Turgeon
    Department of Pharmacology and Molecular Biology, Universite de Montreal, Montreal, Quebec, Canada
    Physiol Rev 89:1-26. 2009
    ..This review provides a guide for the analysis of neonatal lethal phenotypes in mutant mice that will be helpful for dissecting out the function of specific genes during mouse development...
  41. pmc Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors
    Stephane Pelletier
    Institut de Recherches Cliniques de Montréal and Department of Pharmacology, Universite de Montreal, Montreal, Quebec, Canada
    Mol Cell Biol 23:1316-33. 2003
    ..Rho also plays an essential role in the induction of STAT transcriptional activity. Our results highlight a novel role for Rho GTPases in mediating the regulatory effects of GPCRs on STAT-dependent gene expression...
  42. pmc From basic research to clinical development of MEK1/2 inhibitors for cancer therapy
    Christophe Frémin
    Institut de Recherche en Immunologie et Cancérologie and Department of Pharmacology, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Hematol Oncol 3:8. 2010
    ..We then present the current state of clinical evaluation of MEK1/2 inhibitors in cancer and discuss challenges ahead...
  43. ncbi request reprint Chromosomal localization of the mouse genes encoding the ERK1 and ERK2 isoforms of MAP kinases
    M K Saba-El-Leil
    Centre de Recherche, Hotel Dieu de Montreal, Quebec, Canada
    Mamm Genome 8:141-2. 1997
  44. pmc Cloning and characterization of mouse extracellular-signal-regulated protein kinase 3 as a unique gene product of 100 kDa
    B Turgeon
    Research Centre, Centre Hospitalier de l Universite de Montreal, Hotel Dieu Campus, 3850 Saint Urbain Street, Montreal, Quebec, Canada
    Biochem J 346:169-75. 2000
    ..Finally, we provide several lines of evidence to support the existence of a unique Erk3 gene product of 100 kDa in mammalian cells...
  45. doi request reprint The Non-Classical MAP Kinase ERK3 Controls T Cell Activation
    Miriam Marquis
    Maisonneuve Rosemont Hospital Research Centre, Montreal, Quebec, Canada Department of Microbiology, Infectiology and Immunology, University of Montreal, Quebec, Canada
    PLoS ONE 9:e86681. 2014
    ..Our findings identify the atypical MAPK ERK3 as a new and important regulator of TCR-induced T cell activation. ..
  46. ncbi request reprint Negative regulation of MAPKK by phosphorylation of a conserved serine residue equivalent to Ser212 of MEK1
    Kailesh Gopalbhai
    Institut de Recherches Cliniques de Montréal and the Department of Pharmacology, Universite de Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 278:8118-25. 2003
    ..Our findings suggest that Ser(212) phosphorylation represents an evolutionarily conserved mechanism involved in the negative regulation of MAPKKs...
  47. ncbi request reprint The protein kinase ERK3 is encoded by a single functional gene: genomic analysis of the ERK3 gene family
    Benjamin Turgeon
    Institut de Recherches Cliniques de Montreal, Department of Pharmacology, Universite de Montreal, Montreal, Quebec, H2W 1R7, Canada
    Genomics 80:673-80. 2002
    ..Our analysis demonstrates that the ERK3 subfamily of MAP kinase genes is composed of two functional genes, MAPK6 and MAPK4, and several pseudogenes...
  48. doi request reprint The IKK-related kinases: from innate immunity to oncogenesis
    Jean François Clément
    Faculte de Pharmacie, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Cell Res 18:889-99. 2008
    ..This review will therefore summarize and discuss the role of TBK1 and IKKi in cellular transformation and oncogenesis by focusing on their regulation and substrate specificity...
  49. pmc ER stress affects processing of MHC class I-associated peptides
    Diana P Granados
    Department of Medicine, Institute for Research in Immunology and Cancer, Universite de Montreal, Montreal, Canada
    BMC Immunol 10:10. 2009
    ..We therefore asked whether and how the UPR impinges on MHC I-peptide presentation...
  50. doi request reprint ERKs in Cancer: Friends or Foes?
    Xavier Deschênes-Simard
    Authors Affiliations Département de Biochimie et Médecine Moléculaire Department of Pharmacology and Program in Molecular Biology, Institut de Recherche en Immunologie et Cancérologie, Universite de Montreal, Montreal, Quebec, Canada and Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts
    Cancer Res 74:412-9. 2014
    ..The use of pharmacologic inhibitors targeting this pathway must be carefully evaluated so they are applied to cases in which ERKs are mainly oncogenic. Cancer Res; 74(2); 412-9. ©2014 AACR. ..
  51. ncbi request reprint The Rb-family protein p107 inhibits translation by a PDK1-dependent mechanism
    Constantin Makris
    Institut de Recherches Cliniques de Montréal and Department of Pharmacology, University of Montreal, 110 Pine Avenue West, Montreal, Quebec H2W 1R7, Canada
    Oncogene 21:7891-6. 2002
    ..Overexpression of PDK1 restores the defect in translation elicited by p107. These results suggest that p107 restricts cell growth by interfering with the phosphoinositide 3-kinase (PI3K) signaling pathway...
  52. ncbi request reprint Dual-tag prokaryotic vectors for enhanced expression of full-length recombinant proteins
    Philippe Coulombe
    Clinical Research Institute of Montreal, University of Montreal, Que, H2W 1R7, Montreal, Canada
    Anal Biochem 310:219-22. 2002
  53. doi request reprint Effects of angiotensin-converting enzyme inhibitor versus valsartan on cellular signaling events in heart transplant
    Michel White
    Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Ann Pharmacother 43:831-9. 2009
    ..The changes in the cardiac angiotensin system signaling pathways in the human heart in response to ACE inhibitors versus ARBs have been incompletely studied...
  54. pmc p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis
    G Rodier
    Institut de Recherches Cliniques de Montreal, University of Montreal, Montreal, Quebec, Canada H2W 1R7
    EMBO J 20:6672-82. 2001
    ..This cytoplasmic localization may serve to decrease the abundance of p27 in the nucleus below a certain threshold required for activation of cyclin-Cdk2 complexes...
  55. ncbi request reprint Primary structure, expression and chromosomal locus of a human homolog of rat ERK3
    S Meloche
    Centre de Recherche, Hotel Dieu de Montreal, Quebec, Canada
    Oncogene 13:1575-9. 1996
    ..This information should prove valuable in designing studies to define the cellular function of the ERK3 protein kinase...
  56. ncbi request reprint Assignment of the human angiotensin II type 2 receptor gene (AGTR2) to chromosome Xq22-q23 by fluorescence in situ hybridization
    C Chassagne
    Centre de Recherche, Hotel Dieu de Montreal, Quebec, Canada
    Genomics 25:601-3. 1995
  57. ncbi request reprint Human immunodeficiency virus gp120 and derived peptides activate protein tyrosine kinase p56lck in human CD4 T lymphocytes
    C Hivroz
    INSERM U132, Hopital Necker Enfants Malades, Paris, France
    Eur J Immunol 23:600-7. 1993
    ..This activation led to a specific pattern of tyrosine phosphorylation on cellular proteins that may be of significance in the biological effects of the gp120/CD4 interaction, e.g. syncytium formation and inhibition of T cell activation...