Research Topics
Species | Kelly A MecklingSummaryCountry: Canada Publications
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Publications
Comparison of a low-fat diet to a low-carbohydrate diet on weight loss, body composition, and risk factors for diabetes and cardiovascular disease in free-living, overweight men and womenKelly A Meckling
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, N1G 2W1 Ontario, Canada
J Clin Endocrinol Metab 89:2717-23. 2004..These data suggest that energy restriction achieved by a very LC diet is equally effective as a LF diet strategy for weight loss and decreasing body fat in overweight and obese adults...
A randomized trial of a hypocaloric high-protein diet, with and without exercise, on weight loss, fitness, and markers of the Metabolic Syndrome in overweight and obese womenKelly A Meckling
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada
Appl Physiol Nutr Metab 32:743-52. 2007....
In vitro antioxidant synergism and antagonism between food extracts can lead to similar activities in H2O2-induced cell death, caspase-3 and MMP-2 activities in H9c2 cellsSunan Wang
Guelph Food Research Center, Agriculture and Agri Food Canada, Guelph, Ontario, Canada
J Sci Food Agric 92:2983-93. 2012..This in vitro study evaluated the relationship between the in vitro antioxidant capacity of mixtures and their bioactivity when cardiomyocytes (H9c2) were challenged with H(2)O(2)...
Nuclear translocation of the 1,25D3-MARRS (membrane associated rapid response to steroids) receptor protein and NFkappaB in differentiating NB4 leukemia cellsWenqing Wu
Department of Human Health, University of Guelph, Guelph, Ontario, Canada
Exp Cell Res 316:1101-8. 2010..This suggests a role for 1,25D(3)-MARRS in the nucleus as a regulator of gene expression. Here it may also regulate the activity of NFkappaB and other factors with which it may be interacting...
Effects of a hypocaloric, low-carbohydrate diet on weight loss, blood lipids, blood pressure, glucose tolerance, and body composition in free-living overweight womenKelly A Meckling
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, ON NIG 2W1, Canada
Can J Physiol Pharmacol 80:1095-105. 2002....
Guanosine acts intracellularly to initiate apoptosis in NB4 cells: A role for nucleoside transportSheryl A Flanagan
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
Leuk Lymphoma 48:1816-27. 2007..Expression of the unique guanosine-specific nucleoside transporter csg in NB4 cells may provide an opportunity to harness guanosine-mediated cell death in the treatment of APL and related malignancies while sparing normal cells...
Nucleoside transporter expression and activity is regulated during granulocytic differentiation of NB4 cells in response to all-trans-retinoic acidSheryl A Flanagan
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
Leuk Res 31:955-68. 2007....
Involvement of 1,25D3-MARRS (membrane associated, rapid response steroid-binding), a novel vitamin D receptor, in growth inhibition of breast cancer cellsCynthia L Richard
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G2W1
Exp Cell Res 316:695-703. 2010..Further research should examine the potential for pharmacological or natural agents that modify 1,25D3-MARRS expression or activity as anticancer agents...
Low dose docosahexaenoic acid protects normal colonic epithelial cells from araC toxicityMing C Cha
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
BMC Pharmacol 5:7. 2005..Here we investigate whether the omega-3 fatty acid docosahexaenoic acid (DHA) could selectively target araC toxicity toward colonic tumor cells while protecting the normal cells in vitro...
Fatty acids and exercise affect glucose transport but not tumour growth in F-344 ratsJennifer M Foley
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, ON
Can J Appl Physiol 29:604-22. 2004..High DHA diets may also increase oxidative damage in muscle through enhanced TBARM production...
Synergistic, additive, and antagonistic effects of food mixtures on total antioxidant capacitiesSunan Wang
Guelph Food Research Center, Agriculture and Agri Food Canada, Guelph, Ontario, Canada
J Agric Food Chem 59:960-8. 2011..Compositional changes did not seem to have occurred in the mixture. Results in this study suggest the importance of strategically selecting foods or diets to maximum synergisms as well as to minimum antagonisms in antioxidant activity...
