Lonnie Zwaigenbaum

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint Pregnancy and birth complications in autism and liability to the broader autism phenotype
    Lonnie Zwaigenbaum
    Department of Paediatrics, McMaster University, Hamilton, Ontario, Canada
    J Am Acad Child Adolesc Psychiatry 41:572-9. 2002
  2. ncbi request reprint Two children with muscular dystrophies ascertained due to referral for diagnosis of autism
    Lonnie Zwaigenbaum
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    J Autism Dev Disord 33:193-9. 2003
  3. ncbi request reprint Behavioral manifestations of autism in the first year of life
    Lonnie Zwaigenbaum
    Department of Paediatrics, McMaster Children s Hospital, McMaster University, PO Box 2000, Hamilton, Ont, Canada L8N 3Z5
    Int J Dev Neurosci 23:143-52. 2005
  4. ncbi request reprint Studying the emergence of autism spectrum disorders in high-risk infants: methodological and practical issues
    Lonnie Zwaigenbaum
    Department of Paediatrics, McMaster Children s Hospital at McMaster University, Hamilton, Ontario, Canada
    J Autism Dev Disord 37:466-80. 2007
  5. doi request reprint Investigating the measurement properties of the social responsiveness scale in preschool children with autism spectrum disorders
    Eric Duku
    Offord Centre for Child Studies, McMaster University, Hamilton, ON, Canada
    J Autism Dev Disord 43:860-8. 2013
  6. ncbi request reprint Structure of the autism symptom phenotype: A proposed multidimensional model
    Stelios Georgiades
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Am Acad Child Adolesc Psychiatry 46:188-96. 2007
  7. ncbi request reprint Decomposing the autism phenotype into familial dimensions
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 147:3-9. 2008
  8. doi request reprint A prospective study of autistic-like traits in unaffected siblings of probands with autism spectrum disorder
    Stelios Georgiades
    Offord Centre for Child Studies and McMaster Children s Hospital, McMaster University, Ontario, Canada
    JAMA Psychiatry 70:42-8. 2013
  9. doi request reprint Sex differences in children with autism spectrum disorder identified within a high-risk infant cohort
    Lonnie Zwaigenbaum
    Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
    J Autism Dev Disord 42:2585-96. 2012
  10. doi request reprint Similar developmental trajectories in autism and Asperger syndrome: from early childhood to adolescence
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Canada
    J Child Psychol Psychiatry 50:1459-67. 2009

Detail Information

Publications45

  1. ncbi request reprint Pregnancy and birth complications in autism and liability to the broader autism phenotype
    Lonnie Zwaigenbaum
    Department of Paediatrics, McMaster University, Hamilton, Ontario, Canada
    J Am Acad Child Adolesc Psychiatry 41:572-9. 2002
    ..To understand better the relationship between pregnancy and birth complications and genetic factors in autism...
  2. ncbi request reprint Two children with muscular dystrophies ascertained due to referral for diagnosis of autism
    Lonnie Zwaigenbaum
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    J Autism Dev Disord 33:193-9. 2003
    ..These cases highlight the importance of a thorough neuromotor examination for all children with suspected autism spectrum disorders...
  3. ncbi request reprint Behavioral manifestations of autism in the first year of life
    Lonnie Zwaigenbaum
    Department of Paediatrics, McMaster Children s Hospital, McMaster University, PO Box 2000, Hamilton, Ont, Canada L8N 3Z5
    Int J Dev Neurosci 23:143-52. 2005
    ....
  4. ncbi request reprint Studying the emergence of autism spectrum disorders in high-risk infants: methodological and practical issues
    Lonnie Zwaigenbaum
    Department of Paediatrics, McMaster Children s Hospital at McMaster University, Hamilton, Ontario, Canada
    J Autism Dev Disord 37:466-80. 2007
    ..We suggest possible design and implementation strategies to address these various challenges, based on current research efforts in the field and previous studies involving high-risk populations...
  5. doi request reprint Investigating the measurement properties of the social responsiveness scale in preschool children with autism spectrum disorders
    Eric Duku
    Offord Centre for Child Studies, McMaster University, Hamilton, ON, Canada
    J Autism Dev Disord 43:860-8. 2013
    ..This subset was shown to have enhanced psychometric properties and could be used in measuring social responsiveness among preschool age children with Autism Spectrum Disorders...
  6. ncbi request reprint Structure of the autism symptom phenotype: A proposed multidimensional model
    Stelios Georgiades
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Am Acad Child Adolesc Psychiatry 46:188-96. 2007
    ....
  7. ncbi request reprint Decomposing the autism phenotype into familial dimensions
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 147:3-9. 2008
    ..These findings suggest that non-verbal IQ and language in PDD may arise from independent genetic mechanisms. The implications of this finding for linkage analysis and for identifying genetically informative phenotypes are discussed...
  8. doi request reprint A prospective study of autistic-like traits in unaffected siblings of probands with autism spectrum disorder
    Stelios Georgiades
    Offord Centre for Child Studies and McMaster Children s Hospital, McMaster University, Ontario, Canada
    JAMA Psychiatry 70:42-8. 2013
    ..The presence of autistic-like traits in relatives of individuals with autism spectrum disorder (ASD) is well recognized, but, to our knowledge, the emergence of these traits early in development has not been studied...
  9. doi request reprint Sex differences in children with autism spectrum disorder identified within a high-risk infant cohort
    Lonnie Zwaigenbaum
    Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
    J Autism Dev Disord 42:2585-96. 2012
    ..The lower than expected male-to-female ratio, and the relatively high cognitive level among diagnosed children, suggest that we have identified an unanticipated number of higher-functioning girls with ASD...
  10. doi request reprint Similar developmental trajectories in autism and Asperger syndrome: from early childhood to adolescence
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Canada
    J Child Psychol Psychiatry 50:1459-67. 2009
    ....
  11. ncbi request reprint Differentiating autism and Asperger syndrome on the basis of language delay or impairment
    Terry Bennett
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Autism Dev Disord 38:616-25. 2008
    ..Diagnostic implications are discussed...
  12. doi request reprint Investigating phenotypic heterogeneity in children with autism spectrum disorder: a factor mixture modeling approach
    Stelios Georgiades
    Department of Psychiatry and Behavioural Neurosciences, McMaster University and Offord Centre for Child Studies, Hamilton, ON, Canada
    J Child Psychol Psychiatry 54:206-15. 2013
    ....
  13. doi request reprint Sex differences in repetitive stereotyped behaviors in autism: implications for genetic liability
    Peter Szatmari
    Offord Centre for Child Studies, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 159:5-12. 2012
    ..These data also support the dissociation of the different phenotypic dimensions of ASD in terms of its genetic architecture. The implications of these results for linkage and association studies are discussed...
  14. doi request reprint Brief Report: Relationship between non-verbal IQ and gender in autism
    Ryan Banach
    Department of Family Medicine, McMaster University, Hamilton, ON, Canada
    J Autism Dev Disord 39:188-93. 2009
    ..Similarly, the affected brothers of girls with autism were no different from affected brothers of male probands. These data suggest that MPX and SPX families differ with respect to the relationship between gender and IQ...
  15. doi request reprint Alexithymia in parents of children with autism spectrum disorder
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    J Autism Dev Disord 38:1859-65. 2008
    ..The alexithymia trait appears to be one of the many building blocks that make up the BAP...
  16. doi request reprint Influence of reporting effects on the association between maternal depression and child autism spectrum disorder behaviors
    Teresa Bennett
    Offord Center for Child Studies, Mc Master University, Hamilton, ON, Canada
    J Child Psychol Psychiatry 53:89-96. 2012
    ..Using structural equation modeling, we disaggregated shared from unique variation in the association between latent variable measures of maternal depression and ASD behaviors...
  17. doi request reprint Phenotypic overlap between core diagnostic features and emotional/behavioral problems in preschool children with autism spectrum disorder
    Stelios Georgiades
    Offord Centre for Child Studies, McMaster University, 1200 Main St W, Hamilton, Ontario, Canada
    J Autism Dev Disord 41:1321-9. 2011
    ..This exploratory study contributes to our understanding of the ASD phenotype and provides further support for including emotional/behavioral problems as part of the clinical characterization of children with ASD...
  18. ncbi request reprint Early language and communication development of infants later diagnosed with autism spectrum disorder
    Shelley Mitchell
    Autism Research Unit, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Dev Behav Pediatr 27:S69-78. 2006
    ....
  19. ncbi request reprint Investigating the structure of the restricted, repetitive behaviours and interests domain of autism
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Canada
    J Child Psychol Psychiatry 47:582-90. 2006
    ..Although this conceptualisation is well accepted in the field, the grouping of symptoms is based primarily on clinical judgment rather than on empirical evidence...
  20. doi request reprint Early identification of autism spectrum disorders
    Lonnie Zwaigenbaum
    Department of Pediatrics, University of Alberta, Canada
    Behav Brain Res 251:133-46. 2013
    ....
  21. ncbi request reprint Mapping autism risk loci using genetic linkage and chromosomal rearrangements
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Nat Genet 39:319-28. 2007
    ..Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs...
  22. pmc Genome-wide linkage analyses of quantitative and categorical autism subphenotypes
    Xiao Qing Liu
    Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Biol Psychiatry 64:561-70. 2008
    ..Another strategy is to analyze subsets of families that meet certain clinical criteria to reduce genetic heterogeneity...
  23. doi request reprint Differentiating autism spectrum disorder from other developmental delays in the first two years of life
    Shelley Mitchell
    Department of Speech Language Pathology, University of Toronto, Ontario, Canada
    Dev Disabil Res Rev 17:130-40. 2011
    ..This constellation of features coupled with a flat or declining trajectory in specific aspects of social and communication development, may assist clinicians in targeting early interventions to at-risk infants...
  24. doi request reprint Cortical serotonin type-2 receptor density in parents of children with autism spectrum disorders
    Jeremy Goldberg
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, Canada
    J Autism Dev Disord 39:97-104. 2009
    ..Further research should examine the relationship of reduced 5-HT2 receptor expression to underlying causation and to clinical and neurochemical correlates of autistic behavior...
  25. pmc SHANK1 Deletions in Males with Autism Spectrum Disorder
    Daisuke Sato
    The Centre for Applied Genomics and Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Hum Genet 90:879-87. 2012
    ..The data are also informative for clinical-genetics interpretations of both inherited and sporadic forms of ASD involving SHANK1...
  26. pmc Clinical assessment and management of toddlers with suspected autism spectrum disorder: insights from studies of high-risk infants
    Lonnie Zwaigenbaum
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    Pediatrics 123:1383-91. 2009
    ..It is hoped that ongoing studies will provide an even stronger foundation for evidence-based diagnostic and intervention approaches for this critically important age group...
  27. doi request reprint Neuropsychological impairments on the NEPSY-II among children with FASD
    Carmen Rasmussen
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    Child Neuropsychol 19:337-49. 2013
    ..We examined the pattern of neuropsychological impairments of children with FASD (compared to controls) on NEPSY-II measures of attention and executive functioning, language, memory, visuospatial processing, and social perception...
  28. pmc Rare deletions at the neurexin 3 locus in autism spectrum disorder
    Andrea K Vaags
    Program in Genetics and Genome Biology, The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Hum Genet 90:133-41. 2012
    ..Notwithstanding these clinical complexities, this report on ASD-affected individuals who harbor NRXN3 exonic deletions advances the understanding of the genetic etiology of autism, further enabling molecular diagnoses...
  29. ncbi request reprint Conducting genetic epidemiology studies of autism spectrum disorders: issues in matching
    Peter Szatmari
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Autism Dev Disord 34:49-57. 2004
    ..Matching continues to be an important issue in the planning and conduct of family-genetic studies of the autism spectrum disorders, particularly as the search for autism susceptibility genes enters the next generation of studies...
  30. ncbi request reprint Specifying PDD-NOS: a comparison of PDD-NOS, Asperger syndrome, and autism
    Darlene R Walker
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Am Acad Child Adolesc Psychiatry 43:172-80. 2004
    ....
  31. doi request reprint Advances in the early detection of autism
    Lonnie Zwaigenbaum
    Department of Pediatrics, University of Alberta, Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada
    Curr Opin Neurol 23:97-102. 2010
    ..Early detection and diagnosis of autism spectrum disorders (ASDs) allows opportunities for children and their families to benefit more fully from early supports and interventions...
  32. pmc Contribution of SHANK3 mutations to autism spectrum disorder
    Rainald Moessner
    The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, M5G 1L7, Canada
    Am J Hum Genet 81:1289-97. 2007
    ..The combined data provide support that haploinsufficiency of SHANK3 can cause a monogenic form of autism in sufficient frequency to warrant consideration in clinical diagnostic testing...
  33. pmc Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability
    Abdul Noor
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Sci Transl Med 2:49ra68. 2010
    ..Thus, our systematic screen of PTCHD1 and its 5' flanking regions suggests that this locus is involved in ~1% of individuals with ASD and intellectual disability...
  34. doi request reprint The NeuroDevNet Autism Spectrum Disorders Demonstration Project
    Lonnie Zwaigenbaum
    Department of Pediatrics, University of Alberta, Alberta, Canada
    Semin Pediatr Neurol 18:40-8. 2011
    ..We believe that this research has the potential to transform assessment and care for individuals with ASD...
  35. ncbi request reprint Informative phenotypes for genetic studies of psychiatric disorders
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 144:581-8. 2007
    ..This is a conceptual review with a focus on methodological issues that may arise in psychiatric genetics and examples are taken from the literature on autism, schizophrenia, bipolar disorder, and alcoholism...
  36. doi request reprint Five-year neurocognitive and health outcomes after the neonatal arterial switch operation
    Ruth E Neufeld
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    J Thorac Cardiovasc Surg 136:1413-21, 1421.e1-1421.e2. 2008
    ..We sought to assess the 5-year neurocognition and health of an interprovincial inception cohort undergoing the arterial switch operation for transposition of the great arteries...
  37. ncbi request reprint The Autism Observation Scale for Infants: scale development and reliability data
    Susan E Bryson
    Departments of Pediatrics and Psychology, Dalhousie University and IWK Health Centre, Halifax, Nova Scotia, Canada
    J Autism Dev Disord 38:731-8. 2008
    ..Evidence that the AOSI provides reliable data is the first critical step towards evaluating its efficacy in distinguishing high-risk infants who develop ASD...
  38. ncbi request reprint Brief report: data on the Stanford-Binet Intelligence Scales (5th ed.) in children with autism spectrum disorder
    Jamesie Coolican
    Department of Psychology, Dalhousie University, Halifax, NS, Canada
    J Autism Dev Disord 38:190-7. 2008
    ..However, caution is warranted when using the abbreviated battery, as it misrepresents actual ability in a small percentage of cases...
  39. ncbi request reprint Stability and change among high-functioning children with pervasive developmental disorders: a 2-year outcome study
    Elizabeth Starr
    Faculty of Education, University of Windsor, Windsor, Canada
    J Autism Dev Disord 33:15-22. 2003
    ..Results suggest that the two PDD subtypes represent similar developmental trajectories, although the Asperger syndrome group maintains its advantage. Educational and clinical implications of the results are discussed...
  40. ncbi request reprint Modifier effects in autism at the MAO-A and DBH loci
    Marshall B Jones
    Department of Behavioral Science, The Pennsylvania State University College of Medicine, Hershey, PA, USA
    Am J Med Genet B Neuropsychiatr Genet 126:58-65. 2004
    ..Susceptibility effects were also found but not without qualification. We conclude that maternal genotypes at the MAO-A locus, and possibly at the DBH one, may modify IQ in children with autism through the intrauterine environment...
  41. ncbi request reprint Stereotyped motor behaviors associated with autism in high-risk infants: a pilot videotape analysis of a sibling sample
    Alvin Loh
    The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    J Autism Dev Disord 37:25-36. 2007
    ..Overall, the siblings subsequently diagnosed with ASD and the comparison groups had considerable overlap in their repertoires of stereotyped behaviors...
  42. ncbi request reprint A prospective case series of high-risk infants who developed autism
    Susan E Bryson
    Autism Research Centre, IWK Health Centre, Dalhousie University, 5850 University Avenue, Halifax, NS, Canada, B3K 6R8
    J Autism Dev Disord 37:12-24. 2007
    ..Discussion focuses on issues raised by the pattern of findings...
  43. doi request reprint Immunization uptake in siblings of children with autism
    Ghassan Kuwaik
    Pediatrics 122:684-5; author reply 685-6. 2008
  44. ncbi request reprint The developmental neurobiology of autism spectrum disorder
    Emanuel DiCicco-Bloom
    Department of Neuroscience, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    J Neurosci 26:6897-906. 2006
  45. pmc Structural variation of chromosomes in autism spectrum disorder
    Christian R Marshall
    The Centre for Applied Genomics, The Hospital for Sick Children, Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5G 1L7, Canada
    Am J Hum Genet 82:477-88. 2008
    ..Structural variants were found in sufficiently high frequency influencing ASD to suggest that cytogenetic and microarray analyses be considered in routine clinical workup...