Robert B Zipursky

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint PET and SPECT imaging in psychiatric disorders
    Robert B Zipursky
    Department of Psychiatry and Behavioural Neurosciences, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario
    Can J Psychiatry 52:146-57. 2007
  2. ncbi request reprint Why are the outcomes in patients with schizophrenia so poor?
    Robert B Zipursky
    St Joseph s Healthcare Hamilton, 100 West 5th St, Hamilton, ON, L8N 3K7, Canada
    J Clin Psychiatry 75:20-4. 2014
  3. doi request reprint Risk of symptom recurrence with medication discontinuation in first-episode psychosis: a systematic review
    Robert B Zipursky
    Department of Psychiatry and Behavioural Neurosciences, Michael G DeGroote School of Medicine, McMaster University, St Joseph s Healthcare Hamilton, 100 West 5th Street, Hamilton, Ontario L8N 3K7, Canada Electronic address
    Schizophr Res 152:408-14. 2014
  4. doi request reprint An algorithm-based approach to first-episode schizophrenia: response rates over 3 prospective antipsychotic trials with a retrospective data analysis
    Ofer Agid
    Schizophrenia Program, Centre for Addiction and Mental Health, 250 College St, Toronto, Ontario, M5T 1R8, Canada
    J Clin Psychiatry 72:1439-44. 2011
  5. pmc Electrophysiological evidence for primary semantic memory functional organization deficits in schizophrenia
    Michael Kiang
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    Psychiatry Res 196:171-80. 2012
  6. doi request reprint Test-retest reliability and stability of N400 effects in a word-pair semantic priming paradigm
    Michael Kiang
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Clin Neurophysiol 124:667-74. 2013
  7. doi request reprint Association of abnormal semantic processing with delusion-like ideation in frequent cannabis users: an electrophysiological study
    Michael Kiang
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    Psychopharmacology (Berl) 225:95-104. 2013
  8. ncbi request reprint Early use of clozapine for poorly responding first-episode psychosis
    Ofer Agid
    Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    J Clin Psychopharmacol 27:369-73. 2007
  9. doi request reprint Specialized home treatment versus hospital-based outpatient treatment for first-episode psychosis: a randomized clinical trial
    Carolyn S Dewa
    Health Systems Research and Consulting Unit, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Early Interv Psychiatry 3:304-11. 2009
  10. ncbi request reprint The effect of antipsychotic treatment on Theory of Mind
    Romina Mizrahi
    Centre for Addiction and Mental Health, and Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario, Canada
    Psychol Med 37:595-601. 2007

Detail Information

Publications50

  1. ncbi request reprint PET and SPECT imaging in psychiatric disorders
    Robert B Zipursky
    Department of Psychiatry and Behavioural Neurosciences, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario
    Can J Psychiatry 52:146-57. 2007
    ..To review recent findings from positron emission tomography (PET) and single photon emission computed tomography (SPECT) studies that investigate the pathophysiology and treatment of schizophrenia, depression, and dementia...
  2. ncbi request reprint Why are the outcomes in patients with schizophrenia so poor?
    Robert B Zipursky
    St Joseph s Healthcare Hamilton, 100 West 5th St, Hamilton, ON, L8N 3K7, Canada
    J Clin Psychiatry 75:20-4. 2014
    ....
  3. doi request reprint Risk of symptom recurrence with medication discontinuation in first-episode psychosis: a systematic review
    Robert B Zipursky
    Department of Psychiatry and Behavioural Neurosciences, Michael G DeGroote School of Medicine, McMaster University, St Joseph s Healthcare Hamilton, 100 West 5th Street, Hamilton, Ontario L8N 3K7, Canada Electronic address
    Schizophr Res 152:408-14. 2014
    ....
  4. doi request reprint An algorithm-based approach to first-episode schizophrenia: response rates over 3 prospective antipsychotic trials with a retrospective data analysis
    Ofer Agid
    Schizophrenia Program, Centre for Addiction and Mental Health, 250 College St, Toronto, Ontario, M5T 1R8, Canada
    J Clin Psychiatry 72:1439-44. 2011
    ..Employing a naturalistic design, we examined response rates over 3 circumscribed antipsychotic trials...
  5. pmc Electrophysiological evidence for primary semantic memory functional organization deficits in schizophrenia
    Michael Kiang
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    Psychiatry Res 196:171-80. 2012
    ....
  6. doi request reprint Test-retest reliability and stability of N400 effects in a word-pair semantic priming paradigm
    Michael Kiang
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Clin Neurophysiol 124:667-74. 2013
    ..Validating N400 semantic priming effects as a clinical biomarker requires characterizing their test-retest reliability...
  7. doi request reprint Association of abnormal semantic processing with delusion-like ideation in frequent cannabis users: an electrophysiological study
    Michael Kiang
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    Psychopharmacology (Berl) 225:95-104. 2013
    ..Frequent cannabis use is a risk marker for schizophrenia and delusions, but the neurocognitive mechanisms of this relationship remain unclear...
  8. ncbi request reprint Early use of clozapine for poorly responding first-episode psychosis
    Ofer Agid
    Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    J Clin Psychopharmacol 27:369-73. 2007
    ..The present findings suggest that clozapine may have an important role in the early treatment of first-episode patients whose psychosis does not remit with other second-generation antipsychotics during the first months of treatment...
  9. doi request reprint Specialized home treatment versus hospital-based outpatient treatment for first-episode psychosis: a randomized clinical trial
    Carolyn S Dewa
    Health Systems Research and Consulting Unit, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Early Interv Psychiatry 3:304-11. 2009
    ..This pilot study compared the effectiveness of specialized care that was home based versus hospital based for individuals experiencing their first psychotic episode...
  10. ncbi request reprint The effect of antipsychotic treatment on Theory of Mind
    Romina Mizrahi
    Centre for Addiction and Mental Health, and Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario, Canada
    Psychol Med 37:595-601. 2007
    ..However, it remains unclear whether TOM deficits constitute a trait- or a state-related deficit and whether they respond to antipsychotic treatment, and also whether the change in TOM and change in psychosis are associated...
  11. doi request reprint CE verbal episodic memory impairment in schizophrenia: a comparison with frontal lobe lesion patients
    Bruce K Christensen
    Department of Psychiatry and Behavioural Neuroscience, McMaster University, Hamilton, Ontario, Canada
    Clin Neuropsychol 27:647-66. 2013
    ..These data support tentative arguments that verbal episodic memory deficits in SCZ may be mediated by frontal dysfunction in the right hemisphere...
  12. doi request reprint Depth-of-processing effects on semantic activation deficits in schizophrenia: an electrophysiological investigation
    Michael Kiang
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Ontario, Canada L8S 4K1
    Schizophr Res 133:91-8. 2011
    ..These data provide support for further research on semantic-cueing strategies for cognitive remediation of verbal memory in schizophrenia...
  13. ncbi request reprint Striatal vs extrastriatal dopamine D2 receptors in antipsychotic response--a double-blind PET study in schizophrenia
    Ofer Agid
    Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 32:1209-15. 2007
    ....
  14. ncbi request reprint The formation of abnormal associations in schizophrenia: neural and behavioral evidence
    Jimmy Jensen
    Schizophrenia Program and the PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 33:473-9. 2008
    ..The aberrant activations and response are consistent with the idea that patients aberrantly assign motivational salience to neutral stimuli, and this process may be one of the aberrations that predisposes them to psychosis...
  15. ncbi request reprint Cognitive function and brain structure in females with a history of adolescent-onset anorexia nervosa
    Harold T Chui
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
    Pediatrics 122:e426-37. 2008
    ....
  16. doi request reprint Early detection of psychosis: finding those at clinical high risk
    Jean Addington
    Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Early Interv Psychiatry 2:147-53. 2008
    ..The aim of this paper was to describe the development of a research clinic for individuals who appear to be at risk of developing a psychosis and the process for educating the community and obtaining referrals...
  17. doi request reprint Illness intrusiveness and subjective well-being in schizophrenia
    Monica Bettazzoni
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Nerv Ment Dis 196:798-805. 2008
    ..41). Path analysis indicated that lifestyle disruption mediates the impact of symptoms and treatment on well-being. Implications for these findings and future directions for research are discussed...
  18. doi request reprint Event-related brain potential study of semantic priming in unaffected first-degree relatives of schizophrenia patients
    Michael Kiang
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada St Joseph s Healthcare, Hamilton, Ontario, Canada Electronic address
    Schizophr Res 153:78-86. 2014
    ..N400 amplitudes for unrelated targets did not differ between the three groups. Thus, N400 semantic priming deficits in a visual word-pair paradigm may be an illness biomarker for schizophrenia. ..
  19. doi request reprint MRI-targeted repetitive transcranial magnetic stimulation of Heschl's gyrus for refractory auditory hallucinations
    Daniel M Blumberger
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Brain Stimul 5:577-85. 2012
    ..Priming stimulation (6 Hz) prior to LFL stimulation (hereby simply referred to as priming) has been shown to enhance the neurophysiological effects of LFL rTMS alone and, as such, may lead to greater attenuation of AH...
  20. ncbi request reprint The selective effect of antipsychotics on the different dimensions of the experience of psychosis in schizophrenia spectrum disorders
    Romina Mizrahi
    CAMH, and Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario, Canada
    Schizophr Res 88:111-8. 2006
    ....
  21. pmc The myth of schizophrenia as a progressive brain disease
    Robert B Zipursky
    To whom correspondence should be addressed St Joseph s Healthcare Hamilton, 100 West 5th Street, Hamilton, Ontario L8N3K7, Canada tel 905 522 1155 x 36250, fax 905 381 5633, E mail
    Schizophr Bull 39:1363-72. 2013
    ....
  22. ncbi request reprint A 'navigator' model in emerging mental illness?
    Peter J Bieling
    St Joseph s Healthcare Hamilton, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    Early Interv Psychiatry 7:451-7. 2013
    ..Outside of the area of psychosis, there is little evidence to guide us around a model of care that might be effective, efficient and linked to existing mental health systems...
  23. ncbi request reprint Strategies to enhance patient recruitment and retention in research involving patients with a first episode of mental illness
    Ivana Furimsky
    Mental Health and Addictions Program, St Joseph s Healthcare Hamilton, Hamilton, ON, Canada
    Contemp Clin Trials 29:862-6. 2008
    ..Strategies that were implemented to enhance recruitment and retention in these two studies are also discussed. Finally, ethical issues to consider when implementing these strategies are also highlighted...
  24. pmc Substance use and abuse in first-episode psychosis: prevalence before and after early intervention
    Suzanne Archie
    Department of Psychiatry and Behavioural Neurosciences, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Schizophr Bull 33:1354-63. 2007
    ..Despite the high prevalence of substance abuse among first-episode psychosis (FEP) populations, few studies examine whether early intervention (EI) improves substance abuse...
  25. ncbi request reprint Pregnancy outcome of women using atypical antipsychotic drugs: a prospective comparative study
    Kate McKenna
    Motherisk Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Psychiatry 66:444-9; quiz 546. 2005
    ..Atypical antipsychotics have been on the market since the mid-1990s, and to date there are no prospective comparative studies regarding use during pregnancy...
  26. ncbi request reprint Treatment response to olanzapine and haloperidol and its association with dopamine D receptor occupancy in first-episode psychosis
    Robert B Zipursky
    Department of Psychiatry, University of Toronto, Ontario
    Can J Psychiatry 50:462-9. 2005
    ..We undertook this study to determine whether response to the atypical antipsychotic olanzapine occurs at lower levels of D2 receptor occupancy...
  27. ncbi request reprint Psychotic recurrence after antipsychotic discontinuation
    Robert B Zipursky
    Am J Psychiatry 159:1441-2; author reply 1442. 2002
  28. ncbi request reprint Brain serotonin 5-HT(1A) receptor binding in schizophrenia measured by positron emission tomography and [11C]WAY-100635
    Johannes Tauscher
    PET Centre, Toronto, Ontario
    Arch Gen Psychiatry 59:514-20. 2002
    ....
  29. ncbi request reprint Increasing D2 affinity results in the loss of clozapine's atypical antipsychotic action
    Shitij Kapur
    Department of Psychiatry, University of Toronto, Toronto M5S 3H6, Canada
    Neuroreport 13:831-5. 2002
    ..The implications for the design of future antipsychotics is discussed...
  30. ncbi request reprint Evidence for impaired cortical inhibition in schizophrenia using transcranial magnetic stimulation
    Zafiris J Daskalakis
    Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Department of Psychiatry, Toronto Western General Hospital, University of Toronto, Ontario, Canada
    Arch Gen Psychiatry 59:347-54. 2002
    ....
  31. ncbi request reprint Visual feature conjunction in patients with schizophrenia: an event-related brain potential study
    Claude Alain
    Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, ON, Canada M6A 2E1
    Schizophr Res 57:69-79. 2002
    ....
  32. pmc Structural brain abnormalities in patients with schizophrenia and 22q11 deletion syndrome
    Eva W C Chow
    Department of Psychiatry, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Biol Psychiatry 51:208-15. 2002
    ..In the current study, we used magnetic resonance imaging to characterize the structural brain abnormalities found in adults who have both 22q11 Deletion Syndrome and schizophrenia...
  33. ncbi request reprint Delayed-onset hypothesis of antipsychotic action: a hypothesis tested and rejected
    Ofer Agid
    Schizophrenia Program and the PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Arch Gen Psychiatry 60:1228-35. 2003
    ..To understand the mechanism of action of antipsychotic drugs, it is critical to recognize the time course over which these medications take effect. Current models of antipsychotic action presume a "delayed onset" of action...
  34. ncbi request reprint A multisite Canadian study of outcome of first-episode psychosis treated in publicly funded early intervention services
    Ashok Malla
    Department of Psychiatry, McGill University, Douglas Hospital Research Centre, Montreal, Quebec
    Can J Psychiatry 52:563-71. 2007
    ..The aim of this study was to determine 1-year symptomatic outcome and its predictors in patients with FEP treated at 3 different publicly funded sites...
  35. ncbi request reprint Equivalent occupancy of dopamine D1 and D2 receptors with clozapine: differentiation from other atypical antipsychotics
    Johannes Tauscher
    University of Toronto Department of Psychiatry, Schizophrenia Program
    Am J Psychiatry 161:1620-5. 2004
    ....
  36. ncbi request reprint Stable deficits in gray matter volumes following a first episode of schizophrenia
    Robert B Zipursky
    Schizophr Res 71:515-6. 2004
  37. ncbi request reprint Volumetric MRI measurement of caudate nuclei in antipsychotic-naive patients suffering from a first episode of psychosis
    Sitra Tauscher-Wisniewski
    Department of Neuropsychiatry for Children and Adolescents, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    J Psychiatr Res 39:365-70. 2005
    ..441). In contrast to previous studies in patients treated with typical neuroleptics, this cross-sectional MRI study did not find significant differences in CNV of neuroleptic-naive first-episode patients compared to healthy controls...
  38. ncbi request reprint How antipsychotics work: the patients' perspective
    Romina Mizrahi
    Centre for Addiction and Mental Health CAMH, Toronto, Ontario, Canada M5T 1R8
    Prog Neuropsychopharmacol Biol Psychiatry 29:859-64. 2005
    ..Most previous studies of the patient's perspective have focused on drug tolerability and acceptability-rather than their effects on psychosis per se...
  39. ncbi request reprint Neurobiology of early psychosis
    Matcheri S Keshavan
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, UCH 9B, 4201 St Antoine Boulevard, Detroit, MI, USA
    Br J Psychiatry Suppl 48:s8-18. 2005
    ..Neurobiological studies of the early course of psychoses, such as schizophrenia, allow investigation of pathophysiology without the confounds of illness chronicity and treatment...
  40. ncbi request reprint Course and predictors of weight gain in people with first-episode psychosis treated with olanzapine or haloperidol
    Robert B Zipursky
    Schizophrenia Programme, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5T 1R8
    Br J Psychiatry 187:537-43. 2005
    ..Substantial weight gain is common with many atypical antipsychotics...
  41. ncbi request reprint Randomized trial of olanzapine versus placebo in the symptomatic acute treatment of the schizophrenic prodrome
    Scott W Woods
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 54:453-64. 2003
    ..The prodromal phase of schizophrenic disorders has been described prospectively. The present study aimed to determine the short-term efficacy and safety of olanzapine treatment of prodromal symptoms compared with placebo...
  42. ncbi request reprint Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis
    Thomas H McGlashan
    Department of Psychiatry, Yale University School of Medicine, 301 Cedar St, New Haven, CT 06519, USA
    Am J Psychiatry 163:790-9. 2006
    ..This study assessed the efficacy of olanzapine in delaying or preventing conversion to psychosis and reducing symptoms in people with prodromal symptoms of schizophrenia...
  43. ncbi request reprint Insulin resistance and adiponectin levels in drug-free patients with schizophrenia: A preliminary report
    Tony A Cohn
    Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario
    Can J Psychiatry 51:382-6. 2006
    ..To compare the insulin sensitivity and adiponectin levels of medication-free patients suffering from schizophrenia or schizoaffective disorder with that of matched healthy volunteers...
  44. ncbi request reprint A longitudinal study of neurocognitive function in individuals at-risk for psychosis
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
    Schizophr Res 88:26-35. 2006
    ..The time course and predictive value of cognitive deficits in the development of psychosis has not been established...
  45. ncbi request reprint Quetiapine: an effective antipsychotic in first-episode schizophrenia despite only transiently high dopamine-2 receptor blockade
    Sitra Tauscher-Wisniewski
    Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Canada
    J Clin Psychiatry 63:992-7. 2002
    ..We treated patients experiencing their first episode of schizophrenia with a single daily dose of quetiapine to achieve a transient daily peak of D(2) receptor blockade, to determine if this would lead to an antipsychotic response...
  46. ncbi request reprint Adverse subjective experience with antipsychotics and its relationship to striatal and extrastriatal D2 receptors: a PET study in schizophrenia
    Romina Mizrahi
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5S 2S1
    Am J Psychiatry 164:630-7. 2007
    ..The authors present the first double-blind controlled study to examine the relationship between striatal and extrastriatal dopamine D(2) receptor binding potential and occupancy values and adverse subjective experience...
  47. ncbi request reprint Imaging mental disorders in the 21st century
    Robert B Zipursky
    Can J Psychiatry 52:133-4. 2007
  48. ncbi request reprint Caudate volume changes in first episode psychosis parallel the effects of normal aging: a 5-year follow-up study
    Sitra Tauscher-Wisniewski
    Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Toronto, Canada
    Schizophr Res 58:185-8. 2002
    ..Both groups demonstrated a significant 9% decline in caudate volume. We were unable to replicate previous reports of caudate enlargement in patients receiving antipsychotic treatment...
  49. ncbi request reprint Predictors of antipsychotic medication adherence in patients recovering from a first psychotic episode
    Diana O Perkins
    Department of Psychiatry, C B 7160, University of North Carolina School of Medicine, Chapel Hill, 27599 7160, USA
    Schizophr Res 83:53-63. 2006
    ..Factors associated with treatment adherence in patients with chronic schizophrenia include beliefs about severity of illness and need for treatment, treatment with typical versus atypical antipsychotic and medication side effects...
  50. ncbi request reprint Use of atypical antipsychotics during pregnancy and the risk of neural tube defects in infants
    Gideon Koren
    Division of Clinical Pharmacology Toxicology, The Hospital for Sick Children, Toronto, Ont, Canada
    Am J Psychiatry 159:136-7. 2002
    ..Atypical antipsychotics cause various degrees of weight gain. The authors assessed folate status and obesity among patients with schizophrenia receiving atypical antipsychotics...