Robert B Zipursky
Affiliation: McMaster University
- PET and SPECT imaging in psychiatric disordersRobert B Zipursky
Department of Psychiatry and Behavioural Neurosciences, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario
Can J Psychiatry 52:146-57. 2007..To review recent findings from positron emission tomography (PET) and single photon emission computed tomography (SPECT) studies that investigate the pathophysiology and treatment of schizophrenia, depression, and dementia...
- Substance use and abuse in first-episode psychosis: prevalence before and after early interventionSuzanne Archie
Department of Psychiatry and Behavioural Neurosciences, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
Schizophr Bull 33:1354-63. 2007..Despite the high prevalence of substance abuse among first-episode psychosis (FEP) populations, few studies examine whether early intervention (EI) improves substance abuse...
- Treatment response to olanzapine and haloperidol and its association with dopamine D receptor occupancy in first-episode psychosisRobert B Zipursky
Department of Psychiatry, University of Toronto, Ontario
Can J Psychiatry 50:462-9. 2005..We undertook this study to determine whether response to the atypical antipsychotic olanzapine occurs at lower levels of D2 receptor occupancy...
- Course and predictors of weight gain in people with first-episode psychosis treated with olanzapine or haloperidolRobert B Zipursky
Schizophrenia Programme, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5T 1R8
Br J Psychiatry 187:537-43. 2005..Substantial weight gain is common with many atypical antipsychotics...
- Predictors of antipsychotic medication adherence in patients recovering from a first psychotic episodeDiana O Perkins
Department of Psychiatry, C B 7160, University of North Carolina School of Medicine, Chapel Hill, 27599 7160, USA
Schizophr Res 83:53-63. 2006..Factors associated with treatment adherence in patients with chronic schizophrenia include beliefs about severity of illness and need for treatment, treatment with typical versus atypical antipsychotic and medication side effects...
- Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosisThomas H McGlashan
Department of Psychiatry, Yale University School of Medicine, 301 Cedar St, New Haven, CT 06519, USA
Am J Psychiatry 163:790-9. 2006..This study assessed the efficacy of olanzapine in delaying or preventing conversion to psychosis and reducing symptoms in people with prodromal symptoms of schizophrenia...
- Insulin resistance and adiponectin levels in drug-free patients with schizophrenia: A preliminary reportTony A Cohn
Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario
Can J Psychiatry 51:382-6. 2006..To compare the insulin sensitivity and adiponectin levels of medication-free patients suffering from schizophrenia or schizoaffective disorder with that of matched healthy volunteers...
- A longitudinal study of neurocognitive function in individuals at-risk for psychosisRichard S E Keefe
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
Schizophr Res 88:26-35. 2006..The time course and predictive value of cognitive deficits in the development of psychosis has not been established...
- The selective effect of antipsychotics on the different dimensions of the experience of psychosis in schizophrenia spectrum disordersRomina Mizrahi
CAMH, and Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario, Canada
Schizophr Res 88:111-8. 2006....
- Striatal vs extrastriatal dopamine D2 receptors in antipsychotic response--a double-blind PET study in schizophreniaOfer Agid
Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, ON, Canada
Neuropsychopharmacology 32:1209-15. 2007....
- The effect of antipsychotic treatment on Theory of MindRomina Mizrahi
Centre for Addiction and Mental Health, and Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario, Canada
Psychol Med 37:595-601. 2007..However, it remains unclear whether TOM deficits constitute a trait- or a state-related deficit and whether they respond to antipsychotic treatment, and also whether the change in TOM and change in psychosis are associated...
- Adverse subjective experience with antipsychotics and its relationship to striatal and extrastriatal D2 receptors: a PET study in schizophreniaRomina Mizrahi
Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5S 2S1
Am J Psychiatry 164:630-7. 2007..The authors present the first double-blind controlled study to examine the relationship between striatal and extrastriatal dopamine D(2) receptor binding potential and occupancy values and adverse subjective experience...
- The formation of abnormal associations in schizophrenia: neural and behavioral evidenceJimmy Jensen
Schizophrenia Program and the PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
Neuropsychopharmacology 33:473-9. 2008..The aberrant activations and response are consistent with the idea that patients aberrantly assign motivational salience to neutral stimuli, and this process may be one of the aberrations that predisposes them to psychosis...
- Imaging mental disorders in the 21st centuryRobert B Zipursky
Can J Psychiatry 52:133-4. 2007
- Early use of clozapine for poorly responding first-episode psychosisOfer Agid
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
J Clin Psychopharmacol 27:369-73. 2007....
- Use of atypical antipsychotics during pregnancy and the risk of neural tube defects in infantsGideon Koren
Division of Clinical Pharmacology Toxicology, The Hospital for Sick Children, Toronto, Ont, Canada
Am J Psychiatry 159:136-7. 2002..Atypical antipsychotics cause various degrees of weight gain. The authors assessed folate status and obesity among patients with schizophrenia receiving atypical antipsychotics...
- Neurobiology of early psychosisMatcheri S Keshavan
Department of Psychiatry and Behavioral Neurosciences, Wayne State University, UCH 9B, 4201 St Antoine Boulevard, Detroit, MI, USA
Br J Psychiatry Suppl 48:s8-18. 2005..Neurobiological studies of the early course of psychoses, such as schizophrenia, allow investigation of pathophysiology without the confounds of illness chronicity and treatment...
- How antipsychotics work: the patients' perspectiveRomina Mizrahi
Centre for Addiction and Mental Health CAMH, Toronto, Ontario, Canada M5T 1R8
Prog Neuropsychopharmacol Biol Psychiatry 29:859-64. 2005..Most previous studies of the patient's perspective have focused on drug tolerability and acceptability-rather than their effects on psychosis per se...
- Structural brain abnormalities in patients with schizophrenia and 22q11 deletion syndromeEva W C Chow
Department of Psychiatry, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Biol Psychiatry 51:208-15. 2002..In the current study, we used magnetic resonance imaging to characterize the structural brain abnormalities found in adults who have both 22q11 Deletion Syndrome and schizophrenia...
- Evidence for impaired cortical inhibition in schizophrenia using transcranial magnetic stimulationZafiris J Daskalakis
Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Department of Psychiatry, Toronto Western General Hospital, University of Toronto, Ontario, Canada
Arch Gen Psychiatry 59:347-54. 2002....
- Increasing D2 affinity results in the loss of clozapine's atypical antipsychotic actionShitij Kapur
Department of Psychiatry, University of Toronto, Toronto M5S 3H6, Canada
Neuroreport 13:831-5. 2002..The implications for the design of future antipsychotics is discussed...
- Brain serotonin 5-HT(1A) receptor binding in schizophrenia measured by positron emission tomography and [11C]WAY-100635Johannes Tauscher
PET Centre, Toronto, Ontario
Arch Gen Psychiatry 59:514-20. 2002....
- Psychotic recurrence after antipsychotic discontinuationRobert B Zipursky
Am J Psychiatry 159:1441-2; author reply 1442. 2002
- Visual feature conjunction in patients with schizophrenia: an event-related brain potential studyClaude Alain
Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, ON, Canada M6A 2E1
Schizophr Res 57:69-79. 2002....
- Caudate volume changes in first episode psychosis parallel the effects of normal aging: a 5-year follow-up studySitra Tauscher-Wisniewski
Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Toronto, Canada
Schizophr Res 58:185-8. 2002..Both groups demonstrated a significant 9% decline in caudate volume. We were unable to replicate previous reports of caudate enlargement in patients receiving antipsychotic treatment...
- Quetiapine: an effective antipsychotic in first-episode schizophrenia despite only transiently high dopamine-2 receptor blockadeSitra Tauscher-Wisniewski
Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Canada
J Clin Psychiatry 63:992-7. 2002..We treated patients experiencing their first episode of schizophrenia with a single daily dose of quetiapine to achieve a transient daily peak of D(2) receptor blockade, to determine if this would lead to an antipsychotic response...
- Randomized trial of olanzapine versus placebo in the symptomatic acute treatment of the schizophrenic prodromeScott W Woods
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
Biol Psychiatry 54:453-64. 2003..The prodromal phase of schizophrenic disorders has been described prospectively. The present study aimed to determine the short-term efficacy and safety of olanzapine treatment of prodromal symptoms compared with placebo...
- Delayed-onset hypothesis of antipsychotic action: a hypothesis tested and rejectedOfer Agid
Schizophrenia Program and the PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Arch Gen Psychiatry 60:1228-35. 2003..To understand the mechanism of action of antipsychotic drugs, it is critical to recognize the time course over which these medications take effect. Current models of antipsychotic action presume a "delayed onset" of action...
- Equivalent occupancy of dopamine D1 and D2 receptors with clozapine: differentiation from other atypical antipsychoticsJohannes Tauscher
University of Toronto Department of Psychiatry, Schizophrenia Program
Am J Psychiatry 161:1620-5. 2004....
- Stable deficits in gray matter volumes following a first episode of schizophreniaRobert B Zipursky
Schizophr Res 71:515-6. 2004
- Volumetric MRI measurement of caudate nuclei in antipsychotic-naive patients suffering from a first episode of psychosisSitra Tauscher-Wisniewski
Department of Neuropsychiatry for Children and Adolescents, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
J Psychiatr Res 39:365-70. 2005..441). In contrast to previous studies in patients treated with typical neuroleptics, this cross-sectional MRI study did not find significant differences in CNV of neuroleptic-naive first-episode patients compared to healthy controls...
- Pregnancy outcome of women using atypical antipsychotic drugs: a prospective comparative studyKate McKenna
Motherisk Program, The Hospital for Sick Children, Toronto, Ontario, Canada
J Clin Psychiatry 66:444-9; quiz 546. 2005..Atypical antipsychotics have been on the market since the mid-1990s, and to date there are no prospective comparative studies regarding use during pregnancy...
- A multisite Canadian study of outcome of first-episode psychosis treated in publicly funded early intervention servicesAshok Malla
Department of Psychiatry, McGill University, Douglas Hospital Research Centre, Montreal, Quebec
Can J Psychiatry 52:563-71. 2007..The aim of this study was to determine 1-year symptomatic outcome and its predictors in patients with FEP treated at 3 different publicly funded sites...