Salim Yusuf

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi Effects of reviparin, a low-molecular-weight heparin, on mortality, reinfarction, and strokes in patients with acute myocardial infarction presenting with ST-segment elevation
    Salim Yusuf
    Population Health Research Institute, Hamilton Health Sciences, Hamilton General Hospital and McMaster University, Hamilton, Ontario, Canada
    JAMA 293:427-35. 2005
  2. ncbi Defining obesity cut points in a multiethnic population
    Fahad Razak
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    Circulation 115:2111-8. 2007
  3. ncbi C-reactive protein as a screening test for cardiovascular risk in a multiethnic population
    Sonia S Anand
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Arterioscler Thromb Vasc Biol 24:1509-15. 2004
  4. ncbi Metabolic syndrome and risk of acute myocardial infarction a case-control study of 26,903 subjects from 52 countries
    Andrew Mente
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    J Am Coll Cardiol 55:2390-8. 2010
  5. ncbi Design and rationale of CURRENT-OASIS 7: a randomized, 2 x 2 factorial trial evaluating optimal dosing strategies for clopidogrel and aspirin in patients with ST and non-ST-elevation acute coronary syndromes managed with an early invasive strategy
    Shamir R Mehta
    McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Am Heart J 156:1080-1088.e1. 2008
  6. ncbi Impact of candesartan on nonfatal myocardial infarction and cardiovascular death in patients with heart failure
    Catherine Demers
    McMaster University, Hamilton, Ontario, Canada
    JAMA 294:1794-8. 2005
  7. ncbi Irbesartan in patients with atrial fibrillation
    Salim Yusuf
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    N Engl J Med 364:928-38. 2011
  8. ncbi Effect of ramipril and of rosiglitazone on carotid intima-media thickness in people with impaired glucose tolerance or impaired fasting glucose: STARR (STudy of Atherosclerosis with Ramipril and Rosiglitazone)
    Eva M Lonn
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    J Am Coll Cardiol 53:2028-35. 2009
  9. ncbi Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample
    Salam A Al-Attar
    Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Diabetol 7:5. 2008
  10. ncbi Efficacy and safety of fondaparinux versus enoxaparin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: results from the OASIS-5 trial
    Shamir R Mehta
    Department of Medicine, McMaster University and Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
    J Am Coll Cardiol 50:1742-51. 2007

Collaborators

Detail Information

Publications162 found, 100 shown here

  1. ncbi Effects of reviparin, a low-molecular-weight heparin, on mortality, reinfarction, and strokes in patients with acute myocardial infarction presenting with ST-segment elevation
    Salim Yusuf
    Population Health Research Institute, Hamilton Health Sciences, Hamilton General Hospital and McMaster University, Hamilton, Ontario, Canada
    JAMA 293:427-35. 2005
    ..No antithrombotic or newer antiplatelet drug has been shown to reduce mortality in acute MI...
  2. ncbi Defining obesity cut points in a multiethnic population
    Fahad Razak
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    Circulation 115:2111-8. 2007
    ..It is unknown whether these cut points are appropriate for non-European populations. We assessed the metabolic risk associated with BMI among South Asians, Chinese, Aboriginals, and Europeans...
  3. ncbi C-reactive protein as a screening test for cardiovascular risk in a multiethnic population
    Sonia S Anand
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Arterioscler Thromb Vasc Biol 24:1509-15. 2004
    ..Small increases in the inflammatory marker C-reactive protein (CRP) are predictive of vascular events among asymptomatic individuals. There are few data supporting the use of CRP as a risk marker among nonwhite individuals...
  4. ncbi Metabolic syndrome and risk of acute myocardial infarction a case-control study of 26,903 subjects from 52 countries
    Andrew Mente
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    J Am Coll Cardiol 55:2390-8. 2010
    ..This study examines the risk of acute myocardial infarction (MI) conferred by the metabolic syndrome (MS) and its individual factors in multiple ethnic populations...
  5. ncbi Design and rationale of CURRENT-OASIS 7: a randomized, 2 x 2 factorial trial evaluating optimal dosing strategies for clopidogrel and aspirin in patients with ST and non-ST-elevation acute coronary syndromes managed with an early invasive strategy
    Shamir R Mehta
    McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Am Heart J 156:1080-1088.e1. 2008
    ....
  6. ncbi Impact of candesartan on nonfatal myocardial infarction and cardiovascular death in patients with heart failure
    Catherine Demers
    McMaster University, Hamilton, Ontario, Canada
    JAMA 294:1794-8. 2005
    ..CONCLUSION: In patients with heart failure, candesartan significantly reduces the risk of the composite outcome of cardiovascular death or nonfatal MI...
  7. ncbi Irbesartan in patients with atrial fibrillation
    Salim Yusuf
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    N Engl J Med 364:928-38. 2011
    ..The risk of cardiovascular events among patients with atrial fibrillation is high. We evaluated whether irbesartan, an angiotensin-receptor blocker, would reduce this risk...
  8. ncbi Effect of ramipril and of rosiglitazone on carotid intima-media thickness in people with impaired glucose tolerance or impaired fasting glucose: STARR (STudy of Atherosclerosis with Ramipril and Rosiglitazone)
    Eva M Lonn
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    J Am Coll Cardiol 53:2028-35. 2009
    ....
  9. ncbi Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample
    Salam A Al-Attar
    Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Diabetol 7:5. 2008
    ..The objective of this study is to examine whether this association extends to metabolic syndrome (MetS) and applies in non-Caucasian samples...
  10. ncbi Efficacy and safety of fondaparinux versus enoxaparin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: results from the OASIS-5 trial
    Shamir R Mehta
    Department of Medicine, McMaster University and Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
    J Am Coll Cardiol 50:1742-51. 2007
    ..This study reports a prospectively planned analysis of patients with acute coronary syndrome who underwent early percutaneous coronary intervention (PCI) in the OASIS-5 (Fifth Organization to Assess Strategies in Ischemic Syndromes) trial...
  11. ncbi Antithrombotic therapy with fondaparinux in relation to interventional management strategy in patients with ST- and non-ST-segment elevation acute coronary syndromes: an individual patient-level combined analysis of the Fifth and Sixth Organization to Ass
    Shamir R Mehta
    McMaster University, Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Circulation 118:2038-46. 2008
    ..Combined results for these 2 trials on major efficacy and safety outcomes and data on the effects of fondaparinux in relation to interventional management strategy have not been previously reported...
  12. ncbi Usefulness of temporal changes in neurohormones as markers of ventricular remodeling and prognosis in patients with left ventricular systolic dysfunction and heart failure receiving either candesartan or enalapril or both
    Raymond T Yan
    The University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 96:698-704. 2005
    ..Serial measurements of these neurohormones may serve as useful surrogate markers of ventricular remodeling and prognosticators for clinical risk stratification...
  13. ncbi Glucose intolerance and diabetes as risk factors for cognitive impairment in people at high cardiovascular risk: results from the ONTARGET/TRANSCEND research programme
    Tali Cukierman-Yaffe
    Population Health Research Institute, McMaster University, Canada
    Diabetes Res Clin Pract 83:387-93. 2009
    ..To assess the cross-sectional associations of the measures of glycemia and cognitive function in subjects at high cardiovascular risk...
  14. ncbi Effects of telmisartan, ramipril, and their combination on left ventricular hypertrophy in individuals at high vascular risk in the Ongoing Telmisartan Alone and in Combination With Ramipril Global End Point Trial and the Telmisartan Randomized Assessment
    Paolo Verdecchia
    McMaster University, Population Health Research Institute, 237 Barton St E, Hamilton, ON L8L2X2 Canada
    Circulation 120:1380-9. 2009
    ..Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers reduce left ventricular hypertrophy (LVH). The effect of these drugs on LVH in high-risk patients without heart failure is unknown...
  15. ncbi Effects of fondaparinux on mortality and reinfarction in patients with acute ST-segment elevation myocardial infarction: the OASIS-6 randomized trial
    Salim Yusuf
    Department of Medicine, McMaster University and Hamilton Health Sciences, McMaster Clinic, Hamilton General Hospital, Hamilton, Ontario, Canada
    JAMA 295:1519-30. 2006
    ..The role of additional antithrombotic agents is unclear, especially among patients not receiving reperfusion therapy...
  16. ncbi Use of secondary prevention drugs for cardiovascular disease in the community in high-income, middle-income, and low-income countries (the PURE Study): a prospective epidemiological survey
    Salim Yusuf
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada
    Lancet 378:1231-43. 2011
    ....
  17. ncbi Two-year outcomes in patients admitted with non-ST elevation acute coronary syndrome: results of the OASIS registry 1 and 2
    Dorairaj Prabhakaran
    McMaster University, Hamilton, Canada
    Indian Heart J 57:217-25. 2005
    ....
  18. ncbi Relationship of metabolic syndrome and fibrinolytic dysfunction to cardiovascular disease
    Sonia S Anand
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Circulation 108:420-5. 2003
    ..Interventions to prevent atherosclerosis progression and improve fibrinolytic function require evaluation in this high-risk group...
  19. ncbi Interrelation of saturated fat, trans fat, alcohol intake, and subclinical atherosclerosis
    Anwar T Merchant
    Population Health Research Institute, Hamilton, Ontario, Canada
    Am J Clin Nutr 87:168-74. 2008
    ..Intake of saturated fat, trans fat, and alcohol alter cardiovascular disease risk, but their effect on subclinical atherosclerosis remains understudied...
  20. ncbi Progression of renal insufficiency in type 2 diabetes with and without microalbuminuria: results of the Heart Outcomes and Prevention Evaluation (HOPE) randomized study
    Johannes F E Mann
    Department of Cardiology, McMaster University, Hamilton, Canada
    Am J Kidney Dis 42:936-42. 2003
    ..We studied changes in serum creatinine levels during 3.5 to 5.5 years in a large cohort of people with diabetes at high cardiovascular risk with microalbuminuria or normalbuminuria...
  21. ncbi Effect of ramipril on the incidence of diabetes
    Jackie Bosch
    McMaster University, Hamilton, Canada
    N Engl J Med 355:1551-62. 2006
    ..ClinicalTrials.gov number, NCT00095654 [ClinicalTrials.gov].)...
  22. ncbi Cardiovascular and renal outcomes with telmisartan, ramipril, or both in people at high renal risk: results from the ONTARGET and TRANSCEND studies
    Sheldon W Tobe
    Division of Nephrology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Circulation 123:1098-107. 2011
    ..We hypothesized that dual therapy would be more effective than monotherapy in patients with low glomerular filtration rate and elevated albuminuria...
  23. ncbi Comparison of fondaparinux and enoxaparin in acute coronary syndromes
    Salim Yusuf
    Population Health Research Institute, McMaster Clinic, Hamilton General Hospital, 237 Barton St. East, Hamilton, ON L8L 2X2, Canada
    N Engl J Med 354:1464-76. 2006
    ..ClinicalTrials.gov number, NCT00139815.)...
  24. ncbi Apixaban in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 364:806-17. 2011
    ..Apixaban, a novel factor Xa inhibitor, may be an alternative treatment for such patients...
  25. ncbi Net clinical benefit of adding clopidogrel to aspirin therapy in patients with atrial fibrillation for whom vitamin K antagonists are unsuitable
    Stuart J Connolly
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 155:579-86. 2011
    ..Adding clopidogrel to aspirin therapy reduces stroke in patients with atrial fibrillation (AF) but increases hemorrhage...
  26. ncbi Benefit of oral anticoagulant over antiplatelet therapy in atrial fibrillation depends on the quality of international normalized ratio control achieved by centers and countries as measured by time in therapeutic range
    Stuart J Connolly
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Circulation 118:2029-37. 2008
    ..This report examines how differences in time in therapeutic range (TTR) between centers and between countries affect the outcomes of OAC therapy...
  27. ncbi Effects of candesartan on the development of a new diagnosis of diabetes mellitus in patients with heart failure
    Salim Yusuf
    Population Health Research Institute, McMaster University, and Hamilton Health Sciences, Hamilton, Canada
    Circulation 112:48-53. 2005
    ....
  28. ncbi Risks and benefits of oral anticoagulation compared with clopidogrel plus aspirin in patients with atrial fibrillation according to stroke risk: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events (ACTIVE-W)
    Jeff S Healey
    Population Health Research Institute, McMaster University, 237 Barton St E, Hamilton, Ontario, Canada
    Stroke 39:1482-6. 2008
    ..However, because OAC carries important bleeding complications, risk stratification schemes have been devised to identify patients for whom the absolute benefits of OAC exceed its risks...
  29. ncbi Glucose levels compared with diabetes history in the risk assessment of patients with acute myocardial infarction
    Abhinav Goyal
    Population Health Research Institute, Hamilton Health Sciences, Ontario, Canada
    Am Heart J 157:763-70. 2009
    ..Both a history of diabetes mellitus and elevated inhospital glucose levels predict death after acute myocardial infarction (AMI). However, only diabetes history (and not glucose levels) is routinely considered in AMI risk assessment...
  30. ncbi Rationale and design of AVERROES: apixaban versus acetylsalicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable for vitamin K antagonist treatment
    John W Eikelboom
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada L8L 2X2
    Am Heart J 159:348-353.e1. 2010
    ..Apixaban may be an attractive alternative to ASA for prevention of stroke in patients with AF who cannot or will not take a VKA...
  31. ncbi Oral anticoagulant and antiplatelet therapy and peripheral arterial disease
    Sonia Anand
    McMaster University, Hamilton, ON, Canada
    N Engl J Med 357:217-27. 2007
    ..Antiplatelet drugs reduce this risk, but the role of oral anticoagulant agents in the prevention of cardiovascular complications in patients with peripheral arterial disease is unclear...
  32. ncbi Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study
    MARTIN J O'DONNELL
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    Lancet 376:112-23. 2010
    ....
  33. ncbi Piloting a novel algorithm for glucose control in the coronary care unit: the RECREATE (REsearching Coronary REduction by Appropriately Targeting Euglycemia) trial
    Kara A Nerenberg
    Population Health Research Institute McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 35:19-24. 2012
    ..We developed a paper-based glucose-lowering algorithm and assessed its feasibility and safety in the setting of AMI...
  34. ncbi Dietary patterns and the risk of acute myocardial infarction in 52 countries: results of the INTERHEART study
    Romaina Iqbal
    Population Health Research Institute, Michael deGroote School of Medicine, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
    Circulation 118:1929-37. 2008
    ..The objectives of the present study were to assess the association between dietary patterns and acute myocardial infarction (AMI) globally...
  35. ncbi Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: the CREATE-ECLA randomized controlled trial
    Shamir R Mehta
    Department of Medicine, McMaster University, and Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
    JAMA 293:437-46. 2005
    ..Given the potential global importance of GIK infusion, a large, adequately powered randomized trial is required to determine the effect of GIK on mortality in patients with STEMI...
  36. ncbi Polygenic determinants of severe hypertriglyceridemia
    Jian Wang
    Vascular Biology Research Group 2 Clinical Trials Group, Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Hum Mol Genet 17:2894-9. 2008
    ..At the extremes of a quantitative trait, such as severe HTG, are found the cumulative contributions of both multiple rare alleles with large genetic effects and common alleles with small effects...
  37. ncbi Social disadvantage and cardiovascular disease: development of an index and analysis of age, sex, and ethnicity effects
    Sonia S Anand
    Department of Medicine, McMaster University, Hamilton, Canada
    Int J Epidemiol 35:1239-45. 2006
    ..We studied the relationship between social disadvantage, cardiovascular risk factors, and cardiovascular disease (CVD) among men and women from diverse ethno-racial backgrounds...
  38. ncbi Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia
    Christopher T Johansen
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada
    Nat Genet 42:684-7. 2010
    ..1% of affected individuals and 15.3% of controls (P = 2.6 x 10(-5)). Considering rare variants in these genes incrementally increased the proportion of genetic variation contributing to HTG...
  39. ncbi Tobacco use and risk of myocardial infarction in 52 countries in the INTERHEART study: a case-control study
    Koon K Teo
    Population Health Research Institute, McMaster University-Hamilton Health Sciences, Hamilton, ON L8L 2X2, Canada
    Lancet 368:647-58. 2006
    ..All forms of tobacco use, including different types of smoking and chewing tobacco and inhalation of SHS, should be discouraged to prevent cardiovascular diseases...
  40. ncbi Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance
    Andrew Mente
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 33:1629-34. 2010
    ..To investigate ethnic differences in adiponectin and leptin concentration and to determine whether these adipokines and a high-glycemic index diet account for ethnic variation in insulin resistance...
  41. ncbi Effects of aspirin dose on ischaemic events and bleeding after percutaneous coronary intervention: insights from the PCI-CURE study
    Sanjit S Jolly
    Department of Medicine, McMaster University and Population Health Research Institute, Hamilton Health Sciences, Hamilton, Canada
    Eur Heart J 30:900-7. 2009
    ..In the setting of percutaneous coronary intervention (PCI), due to a paucity of data, the optimal dose of aspirin is uncertain. We evaluated the safety of different doses of aspirin after PCI...
  42. ncbi The Prospective Urban Rural Epidemiology (PURE) study: examining the impact of societal influences on chronic noncommunicable diseases in low-, middle-, and high-income countries
    Koon Teo
    Population Health Research Institute, McMaster University Hamilton Health Sciences, Hamilton, Ontario, Canada
    Am Heart J 158:1-7.e1. 2009
    ..The overarching aim of the study is to examine the relationship of societal influences on human lifestyle behaviors, cardiovascular risk factors, and incidence of chronic noncommunicable diseases...
  43. ncbi Risk factors for myocardial infarction in women and men: insights from the INTERHEART study
    Sonia S Anand
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    Eur Heart J 29:932-40. 2008
    ..The purpose of this report is to determine if differences in risk factor distributions exist between women and men across various age categories to help explain why women develop acute MI later than men...
  44. ncbi Rationale, design, and organization of the PeriOperative ISchemic Evaluation (POISE) trial: a randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery
    P J Devereaux
    Faculty of Health Sciences, Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    Am Heart J 152:223-30. 2006
    ..We have initiated the POISE trial to definitively establish the effects of beta-blocker therapy in patients undergoing noncardiac surgery...
  45. ncbi Adverse impact of bleeding on prognosis in patients with acute coronary syndromes
    John W Eikelboom
    Thrombosis Service, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Circulation 114:774-82. 2006
    ..The use of multiple antithrombotic drugs and aggressive invasive strategies has increased the risk of major bleeding in acute coronary syndrome (ACS) patients. It is not known to what extent bleeding determines clinical outcome...
  46. ncbi Reevaluation by high-performance liquid chromatography: clinical significance of microalbuminuria in individuals at high risk of cardiovascular disease in the Heart Outcomes Prevention Evaluation (HOPE) Study
    Matthew J McQueen
    Hamilton Regional Laboratory Medicine Program, Department of Pathology, Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Am J Kidney Dis 48:889-96. 2006
    ..Conventional immunoassays may underestimate albuminuria by not detecting a mildly denatured unfragmented form of albumin, immunounreactive to conventional antibodies...
  47. ncbi Comparative impact of enalapril, candesartan or metoprolol alone or in combination on ventricular remodelling in patients with congestive heart failure
    Robert S McKelvie
    Hamilton Health Sciences, General Division, Ontario, Hamilton, Canada
    Eur Heart J 24:1727-34. 2003
    ..Patients were later randomized to metoprolol CR (M) or placebo. Examine impact of C or E (C/E), C+E, C+M/E+M, C+E+M on ventricular remodelling in heart failure (HF) over 43 weeks...
  48. ncbi Urinary sodium and potassium excretion and risk of cardiovascular events
    MARTIN J O'DONNELL
    Population Health Research Institute, Hamilton General Hospital, McMaster University, 237 Barton St E, Third Floor, Hamilton, ON, L8L 2X2, Canada
    JAMA 306:2229-38. 2011
    ..The precise relationship between sodium and potassium intake and cardiovascular (CV) risk remains uncertain, especially in patients with CV disease...
  49. ncbi Effects of ramipril on left ventricular mass and function in cardiovascular patients with controlled blood pressure and with preserved left ventricular ejection fraction: a substudy of the Heart Outcomes Prevention Evaluation (HOPE) Trial
    Eva Lonn
    Division of Cardiology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Am Coll Cardiol 43:2200-6. 2004
    ..The purpose of this study was to assess the effects of ramipril on left ventricular mass (LVM) and function in vascular disease patients with controlled blood pressure (BP) and with preserved left ventricular ejection fraction (LVEF)...
  50. ncbi Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial
    Sanjit S Jolly
    McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    Lancet 377:1409-20. 2011
    ..We aimed to assess whether radial access was superior to femoral access in patients with acute coronary syndromes (ACS) who were undergoing coronary angiography with possible intervention...
  51. ncbi Prevalence of cardiovascular risk factors in the Middle East: a systematic review
    Bahareh Motlagh
    McMaster University, Population Health Research Institute, Hamilton General Hospital, Ontario, Canada
    Eur J Cardiovasc Prev Rehabil 16:268-80. 2009
    ..The prevalence of obesity and hypertension was higher in women, whereas prevalence of smoking was higher in men. These data suggest that cardiovascular disease will be a major health problem in the Middle East...
  52. ncbi Relationship of electrocardiographic left ventricular hypertrophy to mortality and cardiovascular morbidity in high-risk patients
    Eva Lonn
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Eur J Cardiovasc Prev Rehabil 10:420-8. 2003
    ..The prognostic significance of left ventricular hypertrophy (LVH) identified by simple electrocardiographic (ECG) criteria in high-risk patients with established cardiovascular (CV) diseases is not clearly understood...
  53. ncbi Relationship of activated partial thromboplastin time to coronary events and bleeding in patients with acute coronary syndromes who receive heparin
    Sonia S Anand
    McMaster Clinic Population Health Section, 237 Barton St E, Hamilton, Ontario L8L 2X2, Canada
    Circulation 107:2884-8. 2003
    ..Therefore, it is unclear whether there is an association between recurrent CV events and low APTT values and between bleeding and high APTT values...
  54. ncbi Efficacy and safety of fondaparinux versus enoxaparin in patients with acute coronary syndromes treated with glycoprotein IIb/IIIa inhibitors or thienopyridines: results from the OASIS 5 (Fifth Organization to Assess Strategies in Ischemic Syndromes) tria
    Sanjit S Jolly
    Department of Medicine, Hamilton Health Sciences, Population Health Research Institute, McMaster University, McMaster Clinic Room 630, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada
    J Am Coll Cardiol 54:468-76. 2009
    ..This study sought to evaluate the relative safety and efficacy of fondaparinux and enoxaparin in patients with acute coronary syndromes (ACS) treated with glycoprotein (GP) IIb/IIIa inhibitors or thienopyridines...
  55. ncbi Effects of CYP2C19 genotype on outcomes of clopidogrel treatment
    Guillaume Pare
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 363:1704-14. 2010
    ....
  56. ncbi Telmisartan, ramipril, or both in patients at high risk for vascular events
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 358:1547-59. 2008
    ..We compared the ACE inhibitor ramipril, the ARB telmisartan, and the combination of the two drugs in patients with vascular disease or high-risk diabetes...
  57. ncbi Dysglycemia and a history of reproductive risk factors
    Sarah D McDonald
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, McMaster Universityand Hamilton Health Sciences, Hamilton, Ontario, Canada
    Diabetes Care 31:1635-8. 2008
    ..The purpose of this study was to identify reproductive risk factors associated with dysglycemia (diabetes, impaired glucose tolerance, and impaired fasting glucose) in a contemporary multiethnic population...
  58. ncbi Dabigatran versus warfarin in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 361:1139-51. 2009
    ..Warfarin reduces the risk of stroke in patients with atrial fibrillation but increases the risk of hemorrhage and is difficult to use. Dabigatran is a new oral direct thrombin inhibitor...
  59. ncbi Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: an analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial
    John W Eikelboom
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada
    Circulation 123:2363-72. 2011
    ..The purpose of this study was to compare their risks of bleeding in the Randomized Evaluation of Long-Term Anticoagulant Therapy (RE-LY) trial...
  60. ncbi Relationship of the ApoE polymorphism to plasma lipid traits among South Asians, Chinese, and Europeans living in Canada
    Debika Burman
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada
    Atherosclerosis 203:192-200. 2009
    ..We examined the apolipoprotein E (ApoE) polymorphism, its association with lipid traits and atherosclerosis, and its influence on ethnic variations on lipid traits...
  61. ncbi Challenges in the conduct of large simple trials of important generic questions in resource-poor settings: the CREATE and ECLA trial program evaluating GIK (glucose, insulin and potassium) and low-molecular-weight heparin in acute myocardial infarction
    Salim Yusuf
    Department of Medicine, McMaster University, and Population Health Research Institute, Hamilton General Hospital, Hamilton, Canada
    Am Heart J 148:1068-78. 2004
    ..Although glucose-insulin-potassium (GIK) infusion and low-molecular-weight heparin (LMWH) appear to be promising in AMI, the available trials are inconclusive and these treatments require rigorous evaluation...
  62. ncbi The cost-effectiveness of the use of clopidogrel in acute coronary syndromes in five countries based upon the CURE study
    Andre Lamy
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Eur J Cardiovasc Prev Rehabil 11:460-5. 2004
    ..The CURE study demonstrated that clopidogrel prevents a range of ischaemic cardiovascular events in patients with Acute Coronary Syndromes (unstable angina or non-ST-segment elevation MI)...
  63. ncbi Early versus delayed invasive intervention in acute coronary syndromes
    Shamir R Mehta
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 360:2165-75. 2009
    ..Earlier trials have shown that a routine invasive strategy improves outcomes in patients with acute coronary syndromes without ST-segment elevation. However, the optimal timing of such intervention remains uncertain...
  64. ncbi Telmisartan to prevent recurrent stroke and cardiovascular events
    Salim Yusuf
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    N Engl J Med 359:1225-37. 2008
    ..We evaluated the effects of therapy with an angiotensin-receptor blocker, telmisartan, initiated early after a stroke...
  65. ncbi Unfractionated and low-molecular-weight heparin as adjuncts to thrombolysis in aspirin-treated patients with ST-elevation acute myocardial infarction: a meta-analysis of the randomized trials
    John W Eikelboom
    General Division, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Circulation 112:3855-67. 2005
    ..These data suggest that LMWH should be the preferred antithrombin in this setting...
  66. ncbi Association of diet, exercise, and smoking modification with risk of early cardiovascular events after acute coronary syndromes
    Clara K Chow
    Hamilton General Hospital, 237 Barton St E, Hamilton, Ontario, L8L 2X2, Canada
    Circulation 121:750-8. 2010
    ..The aim of this study was to examine the influence of adherence to behavioral recommendations in the short term on risk of cardiovascular events...
  67. ncbi Clinical decisions. Management of stable coronary disease
    Salim Yusuf
    McMaster University, Hamilton, ON, Canada
    N Engl J Med 357:1762-6. 2007
  68. ncbi Prevalence of mitral valve prolapse in ethnic groups
    Michael Theal
    Department of Medicine and Population Health Research Institute, McMaster University, Hamilton, Canada
    Can J Cardiol 20:511-5. 2004
    ..From a population perspective, the prevalence of serious cardiovascular complications associated with MVP is low...
  69. ncbi The relevance of subgroup-specific treatment effects: the Studies Of Left Ventricular Dysfunction (SOLVD) revisited
    Andrea B Parker
    Institute of Medical Sciences, University of Toronto, and Cardiac Research Inc, Toronto, Ontario, Canada
    Am Heart J 144:941-7. 2002
    ..We reanalyzed the Studies of Left Ventricular Dysfunction (SOLVD) to determine whether the treatment effect depended on the patients' baseline prognosis, defined on the basis of multiple clinical variables...
  70. ncbi Clinical research and trials in developing countries
    Salim Yusuf
    McMaster University, Hamilton, Ontario, Canada
    Stat Med 21:2859-67. 2002
    ....
  71. ncbi Oral anticoagulant therapy in patients with coronary artery disease
    Daniel G Hackam
    Department of MedicineMcMaster University, Hamilton, Ontario, Canada
    Semin Vasc Med 3:323-32. 2003
    ..0 to 3.0) should be considered an option for the prevention of recurrent CAD, particularly in high-risk patients...
  72. ncbi Carbohydrate intake and HDL in a multiethnic population
    Anwar T Merchant
    Population Health Research Institute, Hamilton, Canada
    Am J Clin Nutr 85:225-30. 2007
    ..Ethnic differences in serum lipids are not explained by genetics, central adiposity, lifestyle, or diet, possibly because dietary carbohydrate has not been considered...
  73. ncbi Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: a meta-analysis
    Jeff S Healey
    Population Health Research Institute, McMaster University, and Hamilton Health Sciences, Hamilton, Ontario, Canada
    J Am Coll Cardiol 45:1832-9. 2005
    ....
  74. ncbi Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study
    Matthew J McQueen
    Population Health Research Institute and McMaster University, Hamilton, ON, Canada
    Lancet 372:224-33. 2008
    ..Whether lipoproteins are better markers than lipids and lipoproteins for coronary heart disease is widely debated. Our aim was to compare the apolipoproteins and cholesterol as indices for risk of acute myocardial infarction...
  75. ncbi Canadian-led capacity-building in biostatistics and methodology in cardiovascular and diabetes trials: the CANNeCTIN Biostatistics and Methodological Innovation Working Group
    Lehana Thabane
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada
    Trials 12:48. 2011
    ..The ultimate goal is to enhance global health by contributing to efforts to reduce the burden of CVD and DM...
  76. ncbi A family-based intervention to promote healthy lifestyles in an aboriginal community in Canada
    Sonia S Anand
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Can J Public Health 98:447-52. 2007
    ..Obesity is a major public health problem in North America, particularly in Aboriginal people...
  77. ncbi Polypharmacotherapy for primary prevention of cardiovascular disease
    Denis Xavier
    Population Health Research Institute, Department of Medicine, McMaster University, Hamilton, Canada
    Indian Heart J 60:B29-33. 2008
    ..Such FDC therapy may reduce costs, improve adherence, and reduce CVD events at the population level; especially in developing countries such as India...
  78. ncbi Iatrogenic adverse events in the coronary care unit
    Sherali A Rahim
    Division of Cardiology, Department of Medicine, and the Cardiac and Vascular Program, McMaster University, Hamilton, Ontario, Canada
    Circ Cardiovasc Qual Outcomes 2:437-42. 2009
    ..We sought to determine the frequency and potential preventability of IAEs in the CCU of a tertiary care center...
  79. ncbi Radial versus femoral access for coronary angiography or intervention and the impact on major bleeding and ischemic events: a systematic review and meta-analysis of randomized trials
    Sanjit S Jolly
    Department of Medicine, Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, ON, Canada
    Am Heart J 157:132-40. 2009
    ..The objective of this meta-analysis was to determine if radial access reduces major bleeding and as a result can reduce death and ischemic events compared to femoral access...
  80. ncbi Short- and long-term oral antiplatelet therapy in acute coronary syndromes and percutaneous coronary intervention
    Shamir R Mehta
    Division of Cardiology, McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
    J Am Coll Cardiol 41:79S-88S. 2003
    ....
  81. ncbi Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada
    Lancet 366:1640-9. 2005
    ..We aimed to assess whether markers of obesity, especially waist-to-hip ratio, would be stronger indicators of myocardial infarction than body-mass index (BMI), the conventional measure...
  82. ncbi The relationship between dysglycemia and atherosclerosis in South Asian, Chinese, and European individuals in Canada: a randomly sampled cross-sectional study
    Hertzel C Gerstein
    McMaster University and the Population Health Research Institute, Hamilton, Ontario, Canada
    Diabetes Care 26:144-9. 2003
    ..The relationship between dysglycemia and atherosclerosis (AS) in the general population and in different ethnic groups remains controversial...
  83. ncbi The risks of waiting for cardiac catheterization: a prospective study
    Madhu K Natarajan
    Division of Cardiology, Population Health Research Institute, McMaster University, Hamilton, Ont
    CMAJ 167:1233-40. 2002
    ..A secondary objective was to identify predictors of cardiac events that occur while patients are waiting...
  84. ncbi Routine vs selective invasive strategies in patients with acute coronary syndromes: a collaborative meta-analysis of randomized trials
    Shamir R Mehta
    Department of Medicine, McMaster University, and Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada L6K 1B8
    JAMA 293:2908-17. 2005
    ....
  85. ncbi Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial
    Eva Lonn
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario
    JAMA 293:1338-47. 2005
    ..CONCLUSION: In patients with vascular disease or diabetes mellitus, long-term vitamin E supplementation does not prevent cancer or major cardiovascular events and may increase the risk for heart failure...
  86. ncbi Randomized clinical trials: slow death by a thousand unnecessary policies?
    Salim Yusuf
    Population Health Research Institute, McMaster University, Hamilton, Ont
    CMAJ 171:889-92; discussion 892-3. 2004
  87. ncbi Need for expertise based randomised controlled trials
    P J Devereaux
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street, West Hamilton ON, Canada L8N 3Z5
    BMJ 330:88. 2005
  88. ncbi Effect of long-term therapy with ramipril in high-risk women
    Eva Lonn
    Department of Medicine, Division of Cardiology and Population Health Institute, McMaster University, Hamilton, Ontario, Canada
    J Am Coll Cardiol 40:693-702. 2002
    ..We evaluated the effects of long-term therapy with the angiotensin-converting enzyme (ACE) inhibitor ramipril on major cardiovascular (CV) outcomes in high-risk women...
  89. ncbi Hormone replacement therapy: a time for pause
    Salim Yusuf
    Heart and Stroke Foundation of Ontario, Canadian Institutues of Health Research, McMaster University, Hamilton
    CMAJ 167:357-9. 2002
  90. ncbi Effects of long-term treatment with angiotensin-converting-enzyme inhibitors in the presence or absence of aspirin: a systematic review
    Koon K Teo
    Population Health Research Institute and Division of Cardiology, McMaster University, Ontario, Hamilton, Canada
    Lancet 360:1037-43. 2002
    ..We aimed to confirm or refute this theory...
  91. ncbi Are the recommendations to use perioperative beta-blocker therapy in patients undergoing noncardiac surgery based on reliable evidence?
    P J Devereaux
    Department of Medicine, McMaster University, Hamilton, Ont
    CMAJ 171:245-7. 2004
  92. ncbi Use of ramipril in preventing stroke: double blind randomised trial
    Jackie Bosch
    Canadian Cardiovascular Collaboration, McMaster University, 237 Barton St E, Hamilton, ON, Canada L8L 2X2
    BMJ 324:699-702. 2002
    ..To determine the effect of the angiotensin converting enzyme inhibitor ramipril on the secondary prevention of stroke...
  93. ncbi Nutrient estimation from an FFQ developed for a Black Zimbabwean population
    Anwar T Merchant
    Population Health Research Institute, McMaster University, Hamilton ON, Canada
    Nutr J 4:37. 2005
    ..The aim of this study is to describe the development of an FFQ and a food composition table to calculate nutrient intake in a Black Zimbabwean population...
  94. ncbi Early and late effects of clopidogrel in patients with acute coronary syndromes
    Salim Yusuf
    Population Health Research Institute and Division of Cardiology, McMaster University, Hamilton, Canada
    Circulation 107:966-72. 2003
    ..We examine the benefits and risks associated with the use of adding clopidogrel to aspirin within the first 30 days and later (31 days to 12 months) in 12 562 patients with ACS...
  95. ncbi Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study
    Salim Yusuf
    Population Health Research Institute, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2
    Lancet 364:937-52. 2004
    ..Therefore, the effect of such factors on risk of coronary heart disease in most regions of the world is unknown...
  96. ncbi Choice of clinical outcomes in randomized trials of heart failure therapies: disease-specific or overall outcomes?
    Salim Yusuf
    Division of Cardiology, McMaster University, and the Preventive Cardiology and Therapeutics Program, Hamilton Health Sciences Corporation, Hamilton, Ontario, Canada
    Am Heart J 143:22-8. 2002
    ..There are different views regarding the appropriateness of using cause-specific events or all events as the primary outcome of clinical trials...
  97. ncbi Surveillance and prevention of major perioperative ischemic cardiac events in patients undergoing noncardiac surgery: a review
    P J Devereaux
    Department of Medicine, McMaster University, Hamilton, Ont
    CMAJ 173:779-88. 2005
    ..The best evidence does not support a management strategy of preoperative coronary revascularization before noncardiac surgery...
  98. ncbi Primary angioplasty for ST-segment elevation myocardial infarction: ready for prime time?
    Madhu K Natarajan
    Division of Cardiology, Department of Medicine, and the Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ont
    CMAJ 169:32-5. 2003
  99. ncbi Long-term effects of ramipril on cardiovascular events and on diabetes: results of the HOPE study extension
    Jackie Bosch
    Division of Cardiology, Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Circulation 112:1339-46. 2005
    ..6 years of follow-up and (2) observed in subgroups based on risk and ancillary treatments...
  100. ncbi Determining optimal population rates of cardiac catheterization: a phantom alternative?
    Madhu K Natarajan
    Population Health Research Institute and Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ont
    CMAJ 173:49-52. 2005
  101. ncbi Cardiovascular sequelae of preeclampsia/eclampsia: a systematic review and meta-analyses
    Sarah D McDonald
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Canada
    Am Heart J 156:918-30. 2008
    ..05% to 0.93%, but their subsequent cardiovascular sequelae are unclear. The aim of this study was to determine if women with a history of preeclampsia/eclampsia are at increased risk of long-term cardiovascular sequelae...