Salim Yusuf

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint Effects of reviparin, a low-molecular-weight heparin, on mortality, reinfarction, and strokes in patients with acute myocardial infarction presenting with ST-segment elevation
    Salim Yusuf
    Population Health Research Institute, Hamilton Health Sciences, Hamilton General Hospital and McMaster University, Hamilton, Ontario, Canada
    JAMA 293:427-35. 2005
  2. doi request reprint Comparison of risk factor reduction and tolerability of a full-dose polypill (with potassium) versus low-dose polypill (polycap) in individuals at high risk of cardiovascular diseases: the Second Indian Polycap Study (TIPS-2) investigators
    Salim Yusuf
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, Canada
    Circ Cardiovasc Qual Outcomes 5:463-71. 2012
  3. ncbi request reprint Defining obesity cut points in a multiethnic population
    Fahad Razak
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    Circulation 115:2111-8. 2007
  4. doi request reprint Stroke risk and efficacy of apixaban in atrial fibrillation patients with moderate chronic kidney disease
    John W Eikelboom
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Canada
    J Stroke Cerebrovasc Dis 21:429-35. 2012
  5. ncbi request reprint C-reactive protein as a screening test for cardiovascular risk in a multiethnic population
    Sonia S Anand
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Arterioscler Thromb Vasc Biol 24:1509-15. 2004
  6. pmc Alcohol consumption and the risk of incident atrial fibrillation among people with cardiovascular disease
    Yan Liang
    Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    CMAJ 184:E857-66. 2012
  7. doi request reprint Metabolic syndrome and risk of acute myocardial infarction a case-control study of 26,903 subjects from 52 countries
    Andrew Mente
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    J Am Coll Cardiol 55:2390-8. 2010
  8. doi request reprint Telmisartan, ramipril, or both in patients at high risk for vascular events
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 358:1547-59. 2008
  9. ncbi request reprint Impact of candesartan on nonfatal myocardial infarction and cardiovascular death in patients with heart failure
    Catherine Demers
    McMaster University, Hamilton, Ontario, Canada
    JAMA 294:1794-8. 2005
  10. doi request reprint Irbesartan in patients with atrial fibrillation
    Salim Yusuf
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    N Engl J Med 364:928-38. 2011

Collaborators

Detail Information

Publications179 found, 100 shown here

  1. ncbi request reprint Effects of reviparin, a low-molecular-weight heparin, on mortality, reinfarction, and strokes in patients with acute myocardial infarction presenting with ST-segment elevation
    Salim Yusuf
    Population Health Research Institute, Hamilton Health Sciences, Hamilton General Hospital and McMaster University, Hamilton, Ontario, Canada
    JAMA 293:427-35. 2005
    ..No antithrombotic or newer antiplatelet drug has been shown to reduce mortality in acute MI...
  2. doi request reprint Comparison of risk factor reduction and tolerability of a full-dose polypill (with potassium) versus low-dose polypill (polycap) in individuals at high risk of cardiovascular diseases: the Second Indian Polycap Study (TIPS-2) investigators
    Salim Yusuf
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, Canada
    Circ Cardiovasc Qual Outcomes 5:463-71. 2012
    ..We examined the incremental effects of 2 (full dose) plus K(+) supplementation versus single polycap (low dose) on risk factors and tolerability...
  3. ncbi request reprint Defining obesity cut points in a multiethnic population
    Fahad Razak
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    Circulation 115:2111-8. 2007
    ..It is unknown whether these cut points are appropriate for non-European populations. We assessed the metabolic risk associated with BMI among South Asians, Chinese, Aboriginals, and Europeans...
  4. doi request reprint Stroke risk and efficacy of apixaban in atrial fibrillation patients with moderate chronic kidney disease
    John W Eikelboom
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Canada
    J Stroke Cerebrovasc Dis 21:429-35. 2012
    ..Apixaban is superior to aspirin for the prevention of stroke in patients with atrial fibrillation. Apixaban is partially renally excreted and may accumulate in patients with renal impairment...
  5. ncbi request reprint C-reactive protein as a screening test for cardiovascular risk in a multiethnic population
    Sonia S Anand
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Arterioscler Thromb Vasc Biol 24:1509-15. 2004
    ..Small increases in the inflammatory marker C-reactive protein (CRP) are predictive of vascular events among asymptomatic individuals. There are few data supporting the use of CRP as a risk marker among nonwhite individuals...
  6. pmc Alcohol consumption and the risk of incident atrial fibrillation among people with cardiovascular disease
    Yan Liang
    Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    CMAJ 184:E857-66. 2012
    ..We examined the association between moderate alcohol consumption and the risk of incident atrial fibrillation among older adults with existing cardiovascular disease or diabetes...
  7. doi request reprint Metabolic syndrome and risk of acute myocardial infarction a case-control study of 26,903 subjects from 52 countries
    Andrew Mente
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    J Am Coll Cardiol 55:2390-8. 2010
    ..This study examines the risk of acute myocardial infarction (MI) conferred by the metabolic syndrome (MS) and its individual factors in multiple ethnic populations...
  8. doi request reprint Telmisartan, ramipril, or both in patients at high risk for vascular events
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 358:1547-59. 2008
    ..We compared the ACE inhibitor ramipril, the ARB telmisartan, and the combination of the two drugs in patients with vascular disease or high-risk diabetes...
  9. ncbi request reprint Impact of candesartan on nonfatal myocardial infarction and cardiovascular death in patients with heart failure
    Catherine Demers
    McMaster University, Hamilton, Ontario, Canada
    JAMA 294:1794-8. 2005
    ..Angiotensin-converting enzyme (ACE) inhibitors reduce the risk of myocardial infarction (MI), but it is not known whether angiotensin receptor blockers have the same effect...
  10. doi request reprint Irbesartan in patients with atrial fibrillation
    Salim Yusuf
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    N Engl J Med 364:928-38. 2011
    ..The risk of cardiovascular events among patients with atrial fibrillation is high. We evaluated whether irbesartan, an angiotensin-receptor blocker, would reduce this risk...
  11. doi request reprint Design and rationale of CURRENT-OASIS 7: a randomized, 2 x 2 factorial trial evaluating optimal dosing strategies for clopidogrel and aspirin in patients with ST and non-ST-elevation acute coronary syndromes managed with an early invasive strategy
    Shamir R Mehta
    McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Am Heart J 156:1080-1088.e1. 2008
    ....
  12. doi request reprint Antithrombotic therapy with fondaparinux in relation to interventional management strategy in patients with ST- and non-ST-segment elevation acute coronary syndromes: an individual patient-level combined analysis of the Fifth and Sixth Organization to Ass
    Shamir R Mehta
    McMaster University, Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Circulation 118:2038-46. 2008
    ..Combined results for these 2 trials on major efficacy and safety outcomes and data on the effects of fondaparinux in relation to interventional management strategy have not been previously reported...
  13. ncbi request reprint Efficacy and safety of fondaparinux versus enoxaparin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: results from the OASIS-5 trial
    Shamir R Mehta
    Department of Medicine, McMaster University and Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
    J Am Coll Cardiol 50:1742-51. 2007
    ..This study reports a prospectively planned analysis of patients with acute coronary syndrome who underwent early percutaneous coronary intervention (PCI) in the OASIS-5 (Fifth Organization to Assess Strategies in Ischemic Syndromes) trial...
  14. pmc Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample
    Salam A Al-Attar
    Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Diabetol 7:5. 2008
    ..The objective of this study is to examine whether this association extends to metabolic syndrome (MetS) and applies in non-Caucasian samples...
  15. doi request reprint Effect of ramipril and of rosiglitazone on carotid intima-media thickness in people with impaired glucose tolerance or impaired fasting glucose: STARR (STudy of Atherosclerosis with Ramipril and Rosiglitazone)
    Eva M Lonn
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    J Am Coll Cardiol 53:2028-35. 2009
    ....
  16. doi request reprint Apixaban in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 364:806-17. 2011
    ..Apixaban, a novel factor Xa inhibitor, may be an alternative treatment for such patients...
  17. ncbi request reprint Comparison of fondaparinux and enoxaparin in acute coronary syndromes
    Salim Yusuf
    Population Health Research Institute, McMaster Clinic, Hamilton General Hospital, 237 Barton St East, Hamilton, ON L8L 2X2, Canada
    N Engl J Med 354:1464-76. 2006
    ..We therefore assessed whether fondaparinux would preserve the anti-ischemic benefits of enoxaparin while reducing bleeding...
  18. ncbi request reprint Effect of ramipril on the incidence of diabetes
    Jackie Bosch
    McMaster University, Hamilton, Canada
    N Engl J Med 355:1551-62. 2006
    ..Previous studies have suggested that blockade of the renin-angiotensin system may prevent diabetes in people with cardiovascular disease or hypertension...
  19. doi request reprint Prevalence, awareness, treatment, and control of hypertension in rural and urban communities in high-, middle-, and low-income countries
    Clara K Chow
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada
    JAMA 310:959-68. 2013
    ..Hypertension is the most important preventable cause of morbidity and mortality globally, yet there are relatively few data collected using standardized methods...
  20. doi request reprint Prevalence of a healthy lifestyle among individuals with cardiovascular disease in high-, middle- and low-income countries: The Prospective Urban Rural Epidemiology (PURE) study
    Koon Teo
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    JAMA 309:1613-21. 2013
    ..Little is known about adoption of healthy lifestyle behaviors among individuals with a coronary heart disease (CHD) or stroke event in communities across a range of countries worldwide...
  21. doi request reprint Relationship between healthy diet and risk of cardiovascular disease among patients on drug therapies for secondary prevention: a prospective cohort study of 31 546 high-risk individuals from 40 countries
    Mahshid Dehghan
    Population Health Research Institute, DBCVSRI, Hamilton General Hospital, 237 Barton St E, Hamilton, ON, Canada L8L 2X2
    Circulation 126:2705-12. 2012
    ..This study assessed the association between diet quality and CVD events in a large population of subjects from 40 countries with CVD or diabetes mellitus with end-organ damage receiving proven medications...
  22. doi request reprint Use of secondary prevention drugs for cardiovascular disease in the community in high-income, middle-income, and low-income countries (the PURE Study): a prospective epidemiological survey
    Salim Yusuf
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada
    Lancet 378:1231-43. 2011
    ....
  23. doi request reprint Effects of telmisartan, ramipril, and their combination on left ventricular hypertrophy in individuals at high vascular risk in the Ongoing Telmisartan Alone and in Combination With Ramipril Global End Point Trial and the Telmisartan Randomized Assessment
    Paolo Verdecchia
    McMaster University, Population Health Research Institute, 237 Barton St E, Hamilton, ON L8L2X2 Canada
    Circulation 120:1380-9. 2009
    ..Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers reduce left ventricular hypertrophy (LVH). The effect of these drugs on LVH in high-risk patients without heart failure is unknown...
  24. ncbi request reprint Usefulness of temporal changes in neurohormones as markers of ventricular remodeling and prognosis in patients with left ventricular systolic dysfunction and heart failure receiving either candesartan or enalapril or both
    Raymond T Yan
    The University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 96:698-704. 2005
    ..Serial measurements of these neurohormones may serve as useful surrogate markers of ventricular remodeling and prognosticators for clinical risk stratification...
  25. ncbi request reprint Effects of fondaparinux on mortality and reinfarction in patients with acute ST-segment elevation myocardial infarction: the OASIS-6 randomized trial
    Salim Yusuf
    Department of Medicine, McMaster University and Hamilton Health Sciences, McMaster Clinic, Hamilton General Hospital, Hamilton, Ontario, Canada
    JAMA 295:1519-30. 2006
    ..The role of additional antithrombotic agents is unclear, especially among patients not receiving reperfusion therapy...
  26. doi request reprint Glucose intolerance and diabetes as risk factors for cognitive impairment in people at high cardiovascular risk: results from the ONTARGET/TRANSCEND research programme
    Tali Cukierman-Yaffe
    Population Health Research Institute, McMaster University, Canada
    Diabetes Res Clin Pract 83:387-93. 2009
    ..To assess the cross-sectional associations of the measures of glycemia and cognitive function in subjects at high cardiovascular risk...
  27. doi request reprint Rationale and design of AVERROES: apixaban versus acetylsalicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable for vitamin K antagonist treatment
    John W Eikelboom
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada L8L 2X2
    Am Heart J 159:348-353.e1. 2010
    ..Apixaban may be an attractive alternative to ASA for prevention of stroke in patients with AF who cannot or will not take a VKA...
  28. doi request reprint Variation in warfarin dose adjustment practice is responsible for differences in the quality of anticoagulation control between centers and countries: an analysis of patients receiving warfarin in the randomized evaluation of long-term anticoagulation the
    Harriette G C Van Spall
    Population Health Research Institute, McMaster University, and Hamilton Health Sciences, Hamilton, ON L8L 2X2, Canada
    Circulation 126:2309-16. 2012
    ..The association between warfarin dosing practice, TTR, and clinical outcomes was evaluated in Randomized Evaluation of Long-term Anticoagulation Therapy (RE-LY) trial patients receiving warfarin...
  29. doi request reprint Cardiovascular and renal outcomes with telmisartan, ramipril, or both in people at high renal risk: results from the ONTARGET and TRANSCEND studies
    Sheldon W Tobe
    Division of Nephrology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Circulation 123:1098-107. 2011
    ..We hypothesized that dual therapy would be more effective than monotherapy in patients with low glomerular filtration rate and elevated albuminuria...
  30. ncbi request reprint Relationship of metabolic syndrome and fibrinolytic dysfunction to cardiovascular disease
    Sonia S Anand
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Circulation 108:420-5. 2003
    ..Individuals with this syndrome suffer an excess of cardiovascular disease (CVD) for reasons that are unclear...
  31. ncbi request reprint Interrelation of saturated fat, trans fat, alcohol intake, and subclinical atherosclerosis
    Anwar T Merchant
    Population Health Research Institute, Hamilton, Ontario, Canada
    Am J Clin Nutr 87:168-74. 2008
    ..Intake of saturated fat, trans fat, and alcohol alter cardiovascular disease risk, but their effect on subclinical atherosclerosis remains understudied...
  32. ncbi request reprint Progression of renal insufficiency in type 2 diabetes with and without microalbuminuria: results of the Heart Outcomes and Prevention Evaluation (HOPE) randomized study
    Johannes F E Mann
    Department of Cardiology, McMaster University, Hamilton, Canada
    Am J Kidney Dis 42:936-42. 2003
    ..We studied changes in serum creatinine levels during 3.5 to 5.5 years in a large cohort of people with diabetes at high cardiovascular risk with microalbuminuria or normalbuminuria...
  33. doi request reprint Prospective Urban Rural Epidemiology (PURE) study: Baseline characteristics of the household sample and comparative analyses with national data in 17 countries
    Daniel J Corsi
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada Harvard Center for Population and Development Studies, Cambridge, MA Electronic address
    Am Heart J 166:636-646.e4. 2013
    ..In this analysis we compare the age, sex, urban/rural, mortality, and educational profiles of the PURE participants to national statistics...
  34. ncbi request reprint Two-year outcomes in patients admitted with non-ST elevation acute coronary syndrome: results of the OASIS registry 1 and 2
    Dorairaj Prabhakaran
    McMaster University, Hamilton, Canada
    Indian Heart J 57:217-25. 2005
    ..This study sought to compare baseline characteristics, practice patterns and clinical outcomes for patients with non-ST elevation acute coronary syndrome from a broad range of low-, middle- and high-income countries...
  35. pmc Environmental Profile of a Community's Health (EPOCH): an ecometric assessment of measures of the community environment based on individual perception
    Daniel J Corsi
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 7:e44410. 2012
    ..We evaluate the reliability of a quantitative tool designed to capture perceptions of community tobacco, nutrition, and social environments obtained from interviews with residents in communities in 5 countries...
  36. doi request reprint Effects of off-pump and on-pump coronary-artery bypass grafting at 1 year
    Andre Lamy
    The Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, ON, Canada
    N Engl J Med 368:1179-88. 2013
    ..We now report results on quality of life and cognitive function and on clinical outcomes at 1 year...
  37. ncbi request reprint Effects of candesartan on the development of a new diagnosis of diabetes mellitus in patients with heart failure
    Salim Yusuf
    Population Health Research Institute, McMaster University, and Hamilton Health Sciences, Hamilton, Canada
    Circulation 112:48-53. 2005
    ....
  38. doi request reprint Benefit of oral anticoagulant over antiplatelet therapy in atrial fibrillation depends on the quality of international normalized ratio control achieved by centers and countries as measured by time in therapeutic range
    Stuart J Connolly
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Circulation 118:2029-37. 2008
    ..This report examines how differences in time in therapeutic range (TTR) between centers and between countries affect the outcomes of OAC therapy...
  39. doi request reprint Glucose levels compared with diabetes history in the risk assessment of patients with acute myocardial infarction
    Abhinav Goyal
    Population Health Research Institute, Hamilton Health Sciences, Ontario, Canada
    Am Heart J 157:763-70. 2009
    ..Both a history of diabetes mellitus and elevated inhospital glucose levels predict death after acute myocardial infarction (AMI). However, only diabetes history (and not glucose levels) is routinely considered in AMI risk assessment...
  40. ncbi request reprint Oral anticoagulant and antiplatelet therapy and peripheral arterial disease
    Sonia Anand
    McMaster University, Hamilton, ON, Canada
    N Engl J Med 357:217-27. 2007
    ..Antiplatelet drugs reduce this risk, but the role of oral anticoagulant agents in the prevention of cardiovascular complications in patients with peripheral arterial disease is unclear...
  41. doi request reprint Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study
    MARTIN J O'DONNELL
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    Lancet 376:112-23. 2010
    ....
  42. doi request reprint Net clinical benefit of adding clopidogrel to aspirin therapy in patients with atrial fibrillation for whom vitamin K antagonists are unsuitable
    Stuart J Connolly
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 155:579-86. 2011
    ..Adding clopidogrel to aspirin therapy reduces stroke in patients with atrial fibrillation (AF) but increases hemorrhage...
  43. doi request reprint Risks and benefits of oral anticoagulation compared with clopidogrel plus aspirin in patients with atrial fibrillation according to stroke risk: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events (ACTIVE-W)
    Jeff S Healey
    Population Health Research Institute, McMaster University, 237 Barton St E, Hamilton, Ontario, Canada
    Stroke 39:1482-6. 2008
    ..However, because OAC carries important bleeding complications, risk stratification schemes have been devised to identify patients for whom the absolute benefits of OAC exceed its risks...
  44. doi request reprint Causes of death and influencing factors in patients with atrial fibrillation: a competing-risk analysis from the randomized evaluation of long-term anticoagulant therapy study
    Eloi Marijon
    Paris Cardiovascular Research Center, Paris, France E M Paris Descartes University, Paris, France E M, J Y L H European Georges Pompidou Hospital, Paris, France E M, J Y L H Population Health Research Institute, McMaster University, Hamilton Health Sciences, Hamilton, ON, Canada S C, S Y, J P, J E, E T, S Y Boehringer Ingelheim Pharma GmbH and Co KG, Clinical Development and Medical Affairs, Ingelheim am Rhein, Germany, and Medical Faculty Mannheim of the University of Heidelberg, Heidelberg, Germany M B Cardiovascular Research Foundation and Thomas Jefferson Medical College, New York, NY M E and Uppsala Clinical Research Centre, University Hospital, Uppsala, Sweden L W
    Circulation 128:2192-201. 2013
    ..Atrial fibrillation is associated with increased mortality, but the specific causes of death and their predictors have not been described among patients on effective anticoagulant therapy...
  45. pmc Maternal and pregnancy related predictors of cardiometabolic traits in newborns
    Katherine M Morrison
    Department of Pediatrics, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 8:e55815. 2013
    ..The influence of multiple maternal and pregnancy characteristics on offspring cardiometabolic traits at birth is not well understood and was evaluated in this study...
  46. doi request reprint The CHA2DS2-VASc score identifies those patients with atrial fibrillation and a CHADS2 score of 1 who are unlikely to benefit from oral anticoagulant therapy
    Michiel Coppens
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Eur Heart J 34:170-6. 2013
    ..e. CHADS(2) score of 1)...
  47. pmc Piloting a novel algorithm for glucose control in the coronary care unit: the RECREATE (REsearching Coronary REduction by Appropriately Targeting Euglycemia) trial
    Kara A Nerenberg
    Population Health Research Institute McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 35:19-24. 2012
    ..We developed a paper-based glucose-lowering algorithm and assessed its feasibility and safety in the setting of AMI...
  48. doi request reprint Polygenic determinants of severe hypertriglyceridemia
    Jian Wang
    Vascular Biology Research Group 2 Clinical Trials Group, Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Hum Mol Genet 17:2894-9. 2008
    ..At the extremes of a quantitative trait, such as severe HTG, are found the cumulative contributions of both multiple rare alleles with large genetic effects and common alleles with small effects...
  49. ncbi request reprint Social disadvantage and cardiovascular disease: development of an index and analysis of age, sex, and ethnicity effects
    Sonia S Anand
    Department of Medicine, McMaster University, Hamilton, Canada
    Int J Epidemiol 35:1239-45. 2006
    ..We studied the relationship between social disadvantage, cardiovascular risk factors, and cardiovascular disease (CVD) among men and women from diverse ethno-racial backgrounds...
  50. ncbi request reprint Tobacco use and risk of myocardial infarction in 52 countries in the INTERHEART study: a case-control study
    Koon K Teo
    Population Health Research Institute, McMaster University Hamilton Health Sciences, Hamilton, ON L8L 2X2, Canada
    Lancet 368:647-58. 2006
    ..Tobacco use is one of the major avoidable causes of cardiovascular diseases. We aimed to assess the risks associated with tobacco use (both smoking and non-smoking) and second hand tobacco smoke (SHS) worldwide...
  51. doi request reprint Risk factors for myocardial infarction in women and men: insights from the INTERHEART study
    Sonia S Anand
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    Eur Heart J 29:932-40. 2008
    ..The purpose of this report is to determine if differences in risk factor distributions exist between women and men across various age categories to help explain why women develop acute MI later than men...
  52. doi request reprint Dietary patterns and the risk of acute myocardial infarction in 52 countries: results of the INTERHEART study
    Romaina Iqbal
    Population Health Research Institute, Michael deGroote School of Medicine, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
    Circulation 118:1929-37. 2008
    ..The objectives of the present study were to assess the association between dietary patterns and acute myocardial infarction (AMI) globally...
  53. doi request reprint The Prospective Urban Rural Epidemiology (PURE) study: examining the impact of societal influences on chronic noncommunicable diseases in low-, middle-, and high-income countries
    Koon Teo
    Population Health Research Institute, McMaster University Hamilton Health Sciences, Hamilton, Ontario, Canada
    Am Heart J 158:1-7.e1. 2009
    ..The overarching aim of the study is to examine the relationship of societal influences on human lifestyle behaviors, cardiovascular risk factors, and incidence of chronic noncommunicable diseases...
  54. ncbi request reprint Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: the CREATE-ECLA randomized controlled trial
    Shamir R Mehta
    Department of Medicine, McMaster University, and Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
    JAMA 293:437-46. 2005
    ..Given the potential global importance of GIK infusion, a large, adequately powered randomized trial is required to determine the effect of GIK on mortality in patients with STEMI...
  55. pmc Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia
    Christopher T Johansen
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada
    Nat Genet 42:684-7. 2010
    ..1% of affected individuals and 15.3% of controls (P = 2.6 x 10(-5)). Considering rare variants in these genes incrementally increased the proportion of genetic variation contributing to HTG...
  56. pmc Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance
    Andrew Mente
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 33:1629-34. 2010
    ..To investigate ethnic differences in adiponectin and leptin concentration and to determine whether these adipokines and a high-glycemic index diet account for ethnic variation in insulin resistance...
  57. doi request reprint Effects of aspirin dose on ischaemic events and bleeding after percutaneous coronary intervention: insights from the PCI-CURE study
    Sanjit S Jolly
    Department of Medicine, McMaster University and Population Health Research Institute, Hamilton Health Sciences, Hamilton, Canada
    Eur Heart J 30:900-7. 2009
    ..In the setting of percutaneous coronary intervention (PCI), due to a paucity of data, the optimal dose of aspirin is uncertain. We evaluated the safety of different doses of aspirin after PCI...
  58. doi request reprint Balancing the benefits and risks of 2 doses of dabigatran compared with warfarin in atrial fibrillation
    John W Eikelboom
    Population Health Research Institute, McMaster University, 237 Barton St East, Hamilton, Ontario, Canada
    J Am Coll Cardiol 62:900-8. 2013
    ..This study sought to compare the net clinical benefit of dabigatran 110 mg bid and 150 mg bid with that of warfarin in patients with atrial fibrillation (AF)...
  59. doi request reprint Periprocedural bleeding and thromboembolic events with dabigatran compared with warfarin: results from the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) randomized trial
    Jeff S Healey
    Population Health Research Institute, McMaster University, Hamilton, Canada
    Circulation 126:343-8. 2012
    ..Dabigatran reduces ischemic stroke in comparison with warfarin; however, given the lack of antidote, there is concern that it might increase bleeding when surgery or invasive procedures are required...
  60. doi request reprint Cognitive impairment and risk of cardiovascular events and mortality
    Martin O'Donnell
    Population Health Research Institute, McMaster University, DBCVS Research Institute, Hamilton, Ontario, Canada
    Eur Heart J 33:1777-86. 2012
    ....
  61. doi request reprint Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial
    Sanjit S Jolly
    McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    Lancet 377:1409-20. 2011
    ..We aimed to assess whether radial access was superior to femoral access in patients with acute coronary syndromes (ACS) who were undergoing coronary angiography with possible intervention...
  62. doi request reprint Urinary sodium and potassium excretion and risk of cardiovascular events
    MARTIN J O'DONNELL
    Population Health Research Institute, Hamilton General Hospital, McMaster University, 237 Barton St E, Third Floor, Hamilton, ON, L8L 2X2, Canada
    JAMA 306:2229-38. 2011
    ..The precise relationship between sodium and potassium intake and cardiovascular (CV) risk remains uncertain, especially in patients with CV disease...
  63. ncbi request reprint Adverse impact of bleeding on prognosis in patients with acute coronary syndromes
    John W Eikelboom
    Thrombosis Service, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Circulation 114:774-82. 2006
    ..The use of multiple antithrombotic drugs and aggressive invasive strategies has increased the risk of major bleeding in acute coronary syndrome (ACS) patients. It is not known to what extent bleeding determines clinical outcome...
  64. ncbi request reprint Rationale, design, and organization of the PeriOperative ISchemic Evaluation (POISE) trial: a randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery
    P J Devereaux
    Faculty of Health Sciences, Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    Am Heart J 152:223-30. 2006
    ..We have initiated the POISE trial to definitively establish the effects of beta-blocker therapy in patients undergoing noncardiac surgery...
  65. ncbi request reprint Reevaluation by high-performance liquid chromatography: clinical significance of microalbuminuria in individuals at high risk of cardiovascular disease in the Heart Outcomes Prevention Evaluation (HOPE) Study
    Matthew J McQueen
    Hamilton Regional Laboratory Medicine Program, Department of Pathology, Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Am J Kidney Dis 48:889-96. 2006
    ..Conventional immunoassays may underestimate albuminuria by not detecting a mildly denatured unfragmented form of albumin, immunounreactive to conventional antibodies...
  66. ncbi request reprint Comparative impact of enalapril, candesartan or metoprolol alone or in combination on ventricular remodelling in patients with congestive heart failure
    Robert S McKelvie
    Hamilton Health Sciences, General Division, Ontario, Hamilton, Canada
    Eur Heart J 24:1727-34. 2003
    ..Patients were later randomized to metoprolol CR (M) or placebo. Examine impact of C or E (C/E), C+E, C+M/E+M, C+E+M on ventricular remodelling in heart failure (HF) over 43 weeks...
  67. ncbi request reprint Effects of ramipril on left ventricular mass and function in cardiovascular patients with controlled blood pressure and with preserved left ventricular ejection fraction: a substudy of the Heart Outcomes Prevention Evaluation (HOPE) Trial
    Eva Lonn
    Division of Cardiology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Am Coll Cardiol 43:2200-6. 2004
    ..The purpose of this study was to assess the effects of ramipril on left ventricular mass (LVM) and function in vascular disease patients with controlled blood pressure (BP) and with preserved left ventricular ejection fraction (LVEF)...
  68. doi request reprint Intracranial hemorrhage in atrial fibrillation patients during anticoagulation with warfarin or dabigatran: the RE-LY trial
    Robert G Hart
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
    Stroke 43:1511-7. 2012
    ..Intracranial hemorrhage is the most devastating complication of anticoagulation. Outcomes associated with different sites of intracranial bleeding occurring with warfarin versus dabigatran have not been defined...
  69. doi request reprint Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: an analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial
    John W Eikelboom
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada
    Circulation 123:2363-72. 2011
    ..The purpose of this study was to compare their risks of bleeding in the Randomized Evaluation of Long-Term Anticoagulant Therapy (RE-LY) trial...
  70. pmc Dysglycemia and a history of reproductive risk factors
    Sarah D McDonald
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, McMaster Universityand Hamilton Health Sciences, Hamilton, Ontario, Canada
    Diabetes Care 31:1635-8. 2008
    ..The purpose of this study was to identify reproductive risk factors associated with dysglycemia (diabetes, impaired glucose tolerance, and impaired fasting glucose) in a contemporary multiethnic population...
  71. ncbi request reprint Relationship of activated partial thromboplastin time to coronary events and bleeding in patients with acute coronary syndromes who receive heparin
    Sonia S Anand
    McMaster Clinic Population Health Section, 237 Barton St E, Hamilton, Ontario L8L 2X2, Canada
    Circulation 107:2884-8. 2003
    ..Therefore, it is unclear whether there is an association between recurrent CV events and low APTT values and between bleeding and high APTT values...
  72. ncbi request reprint Challenges in the conduct of large simple trials of important generic questions in resource-poor settings: the CREATE and ECLA trial program evaluating GIK (glucose, insulin and potassium) and low-molecular-weight heparin in acute myocardial infarction
    Salim Yusuf
    Department of Medicine, McMaster University, and Population Health Research Institute, Hamilton General Hospital, Hamilton, Canada
    Am Heart J 148:1068-78. 2004
    ..Although glucose-insulin-potassium (GIK) infusion and low-molecular-weight heparin (LMWH) appear to be promising in AMI, the available trials are inconclusive and these treatments require rigorous evaluation...
  73. doi request reprint Dabigatran versus warfarin in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 361:1139-51. 2009
    ..Warfarin reduces the risk of stroke in patients with atrial fibrillation but increases the risk of hemorrhage and is difficult to use. Dabigatran is a new oral direct thrombin inhibitor...
  74. doi request reprint Relationship of the ApoE polymorphism to plasma lipid traits among South Asians, Chinese, and Europeans living in Canada
    Debika Burman
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada
    Atherosclerosis 203:192-200. 2009
    ..We examined the apolipoprotein E (ApoE) polymorphism, its association with lipid traits and atherosclerosis, and its influence on ethnic variations on lipid traits...
  75. ncbi request reprint The cost-effectiveness of the use of clopidogrel in acute coronary syndromes in five countries based upon the CURE study
    Andre Lamy
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Eur J Cardiovasc Prev Rehabil 11:460-5. 2004
    ..The CURE study demonstrated that clopidogrel prevents a range of ischaemic cardiovascular events in patients with Acute Coronary Syndromes (unstable angina or non-ST-segment elevation MI)...
  76. doi request reprint Efficacy and safety of fondaparinux versus enoxaparin in patients with acute coronary syndromes treated with glycoprotein IIb/IIIa inhibitors or thienopyridines: results from the OASIS 5 (Fifth Organization to Assess Strategies in Ischemic Syndromes) tria
    Sanjit S Jolly
    Department of Medicine, Hamilton Health Sciences, Population Health Research Institute, McMaster University, McMaster Clinic Room 630, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada
    J Am Coll Cardiol 54:468-76. 2009
    ..This study sought to evaluate the relative safety and efficacy of fondaparinux and enoxaparin in patients with acute coronary syndromes (ACS) treated with glycoprotein (GP) IIb/IIIa inhibitors or thienopyridines...
  77. doi request reprint Early versus delayed invasive intervention in acute coronary syndromes
    Shamir R Mehta
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 360:2165-75. 2009
    ..Earlier trials have shown that a routine invasive strategy improves outcomes in patients with acute coronary syndromes without ST-segment elevation. However, the optimal timing of such intervention remains uncertain...
  78. ncbi request reprint Relationship of electrocardiographic left ventricular hypertrophy to mortality and cardiovascular morbidity in high-risk patients
    Eva Lonn
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Eur J Cardiovasc Prev Rehabil 10:420-8. 2003
    ..The prognostic significance of left ventricular hypertrophy (LVH) identified by simple electrocardiographic (ECG) criteria in high-risk patients with established cardiovascular (CV) diseases is not clearly understood...
  79. doi request reprint Prevalence of cardiovascular risk factors in the Middle East: a systematic review
    Bahareh Motlagh
    McMaster University, Population Health Research Institute, Hamilton General Hospital, Ontario, Canada
    Eur J Cardiovasc Prev Rehabil 16:268-80. 2009
    ..The prevalence of obesity and hypertension was higher in women, whereas prevalence of smoking was higher in men. These data suggest that cardiovascular disease will be a major health problem in the Middle East...
  80. doi request reprint Effects of CYP2C19 genotype on outcomes of clopidogrel treatment
    Guillaume Pare
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 363:1704-14. 2010
    ....
  81. pmc Telmisartan to prevent recurrent stroke and cardiovascular events
    Salim Yusuf
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    N Engl J Med 359:1225-37. 2008
    ..We evaluated the effects of therapy with an angiotensin-receptor blocker, telmisartan, initiated early after a stroke...
  82. ncbi request reprint Unfractionated and low-molecular-weight heparin as adjuncts to thrombolysis in aspirin-treated patients with ST-elevation acute myocardial infarction: a meta-analysis of the randomized trials
    John W Eikelboom
    General Division, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Circulation 112:3855-67. 2005
    ..There is uncertainty about the role of intravenous unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH) in patients with ST-elevation myocardial infarction (STEMI) treated with aspirin and thrombolysis...
  83. doi request reprint Association of diet, exercise, and smoking modification with risk of early cardiovascular events after acute coronary syndromes
    Clara K Chow
    Hamilton General Hospital, 237 Barton St E, Hamilton, Ontario, L8L 2X2, Canada
    Circulation 121:750-8. 2010
    ..The aim of this study was to examine the influence of adherence to behavioral recommendations in the short term on risk of cardiovascular events...
  84. ncbi request reprint Clinical decisions. Management of stable coronary disease
    Salim Yusuf
    McMaster University, Hamilton, ON, Canada
    N Engl J Med 357:1762-6. 2007
  85. ncbi request reprint Prevalence of mitral valve prolapse in ethnic groups
    Michael Theal
    Department of Medicine and Population Health Research Institute, McMaster University, Hamilton, Canada
    Can J Cardiol 20:511-5. 2004
    ..From a population perspective, the prevalence of serious cardiovascular complications associated with MVP is low...
  86. ncbi request reprint The relevance of subgroup-specific treatment effects: the Studies Of Left Ventricular Dysfunction (SOLVD) revisited
    Andrea B Parker
    Institute of Medical Sciences, University of Toronto, and Cardiac Research Inc, Toronto, Ontario, Canada
    Am Heart J 144:941-7. 2002
    ..We reanalyzed the Studies of Left Ventricular Dysfunction (SOLVD) to determine whether the treatment effect depended on the patients' baseline prognosis, defined on the basis of multiple clinical variables...
  87. ncbi request reprint Oral anticoagulant therapy in patients with coronary artery disease
    Daniel G Hackam
    Department of MedicineMcMaster University, Hamilton, Ontario, Canada
    Semin Vasc Med 3:323-32. 2003
    ..0 to 3.0) should be considered an option for the prevention of recurrent CAD, particularly in high-risk patients...
  88. ncbi request reprint Clinical research and trials in developing countries
    Salim Yusuf
    McMaster University, Hamilton, Ontario, Canada
    Stat Med 21:2859-67. 2002
    ....
  89. ncbi request reprint Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: a meta-analysis
    Jeff S Healey
    Population Health Research Institute, McMaster University, and Hamilton Health Sciences, Hamilton, Ontario, Canada
    J Am Coll Cardiol 45:1832-9. 2005
    ....
  90. ncbi request reprint Carbohydrate intake and HDL in a multiethnic population
    Anwar T Merchant
    Population Health Research Institute, Hamilton, Canada
    Am J Clin Nutr 85:225-30. 2007
    ..Ethnic differences in serum lipids are not explained by genetics, central adiposity, lifestyle, or diet, possibly because dietary carbohydrate has not been considered...
  91. ncbi request reprint A family-based intervention to promote healthy lifestyles in an aboriginal community in Canada
    Sonia S Anand
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Can J Public Health 98:447-52. 2007
    ..Obesity is a major public health problem in North America, particularly in Aboriginal people...
  92. doi request reprint Iatrogenic adverse events in the coronary care unit
    Sherali A Rahim
    Division of Cardiology, Department of Medicine, and the Cardiac and Vascular Program, McMaster University, Hamilton, Ontario, Canada
    Circ Cardiovasc Qual Outcomes 2:437-42. 2009
    ..We sought to determine the frequency and potential preventability of IAEs in the CCU of a tertiary care center...
  93. pmc Canadian-led capacity-building in biostatistics and methodology in cardiovascular and diabetes trials: the CANNeCTIN Biostatistics and Methodological Innovation Working Group
    Lehana Thabane
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada
    Trials 12:48. 2011
    ..The ultimate goal is to enhance global health by contributing to efforts to reduce the burden of CVD and DM...
  94. doi request reprint Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study
    Matthew J McQueen
    Population Health Research Institute and McMaster University, Hamilton, ON, Canada
    Lancet 372:224-33. 2008
    ..Whether lipoproteins are better markers than lipids and lipoproteins for coronary heart disease is widely debated. Our aim was to compare the apolipoproteins and cholesterol as indices for risk of acute myocardial infarction...
  95. doi request reprint Radial versus femoral access for coronary angiography or intervention and the impact on major bleeding and ischemic events: a systematic review and meta-analysis of randomized trials
    Sanjit S Jolly
    Department of Medicine, Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, ON, Canada
    Am Heart J 157:132-40. 2009
    ..The objective of this meta-analysis was to determine if radial access reduces major bleeding and as a result can reduce death and ischemic events compared to femoral access...
  96. ncbi request reprint Polypharmacotherapy for primary prevention of cardiovascular disease
    Denis Xavier
    Population Health Research Institute, Department of Medicine, McMaster University, Hamilton, Canada
    Indian Heart J 60:B29-33. 2008
    ..Such FDC therapy may reduce costs, improve adherence, and reduce CVD events at the population level; especially in developing countries such as India...
  97. pmc Use of ramipril in preventing stroke: double blind randomised trial
    Jackie Bosch
    Canadian Cardiovascular Collaboration, McMaster University, 237 Barton St E, Hamilton, ON, Canada L8L 2X2
    BMJ 324:699-702. 2002
    ..To determine the effect of the angiotensin converting enzyme inhibitor ramipril on the secondary prevention of stroke...
  98. ncbi request reprint Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study
    Salim Yusuf
    Population Health Research Institute, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2
    Lancet 364:937-52. 2004
    ..Therefore, the effect of such factors on risk of coronary heart disease in most regions of the world is unknown...
  99. pmc Nutrient estimation from an FFQ developed for a Black Zimbabwean population
    Anwar T Merchant
    Population Health Research Institute, McMaster University, Hamilton ON, Canada
    Nutr J 4:37. 2005
    ..The aim of this study is to describe the development of an FFQ and a food composition table to calculate nutrient intake in a Black Zimbabwean population...
  100. pmc Are the recommendations to use perioperative beta-blocker therapy in patients undergoing noncardiac surgery based on reliable evidence?
    P J Devereaux
    Department of Medicine, McMaster University, Hamilton, Ont
    CMAJ 171:245-7. 2004
  101. pmc Need for expertise based randomised controlled trials
    P J Devereaux
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street, West Hamilton ON, Canada L8N 3Z5
    BMJ 330:88. 2005