S Yusuf

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi Variations between countries in invasive cardiac procedures and outcomes in patients with suspected unstable angina or myocardial infarction without initial ST elevation. OASIS (Organisation to Assess Strategies for Ischaemic Syndromes) Registry Investiga
    S Yusuf
    McMaster University, Hamilton, Ontario, Canada
    Lancet 352:507-14. 1998
  2. ncbi The Study of Health Assessment and Risk in Ethnic groups (SHARE): rationale and design. The SHARE Investigators
    S S Anand
    Preventive Cardiology and Therapeutics Research Program, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario
    Can J Cardiol 14:1349-57. 1998
  3. ncbi Differences in risk factors, atherosclerosis, and cardiovascular disease between ethnic groups in Canada: the Study of Health Assessment and Risk in Ethnic groups (SHARE)
    S S Anand
    Department of Medicine, McMaster University, Ontario, Canada
    Lancet 356:279-84. 2000
  4. ncbi Long-term oral anticoagulant therapy in patients with unstable angina or suspected non-Q-wave myocardial infarction: organization to assess strategies for ischemic syndromes (OASIS) pilot study results
    S S Anand
    From the Preventive Cardiology and Therapeutics Program, Hamilton Civics Hospital Research Centre, and Division of Cardiology, McMaster University, Hamilton, Canada
    Circulation 98:1064-70. 1998
  5. ncbi Glucose levels are associated with cardiovascular disease and death in an international cohort of normal glycaemic and dysglycaemic men and women: the EpiDREAM cohort study
    S S Anand
    Population Health Research Institute, Hamilton, Ontario, Canada
    Eur J Prev Cardiol 19:755-64. 2012
  6. ncbi Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study
    S R Mehta
    Division of Cardiology, the Population Health Research Institute and the Canadian Cardiovascular Collaboration Project Office, McMaster University, Hamilton, Canada
    Lancet 358:527-33. 2001
  7. ncbi Prevalence and determinants of microalbuminuria in high-risk diabetic and nondiabetic patients in the Heart Outcomes Prevention Evaluation Study. The HOPE Study Investigators
    H C Gerstein
    McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 23:B35-9. 2000
  8. ncbi Design and rationale of CURRENT-OASIS 7: a randomized, 2 x 2 factorial trial evaluating optimal dosing strategies for clopidogrel and aspirin in patients with ST and non-ST-elevation acute coronary syndromes managed with an early invasive strategy
    Shamir R Mehta
    McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Am Heart J 156:1080-1088.e1. 2008
  9. ncbi Irbesartan in patients with atrial fibrillation
    Salim Yusuf
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    N Engl J Med 364:928-38. 2011
  10. ncbi Stroke in relation to cardiac procedures in patients with non-ST-elevation acute coronary syndrome: a study involving >18 000 patients
    L Cronin
    Preventive Cardiology and Therapeutics Program and the Division of Cardiology, McMaster University, Hamilton, Canada
    Circulation 104:269-74. 2001

Collaborators

Detail Information

Publications84

  1. ncbi Variations between countries in invasive cardiac procedures and outcomes in patients with suspected unstable angina or myocardial infarction without initial ST elevation. OASIS (Organisation to Assess Strategies for Ischaemic Syndromes) Registry Investiga
    S Yusuf
    McMaster University, Hamilton, Ontario, Canada
    Lancet 352:507-14. 1998
    ....
  2. ncbi The Study of Health Assessment and Risk in Ethnic groups (SHARE): rationale and design. The SHARE Investigators
    S S Anand
    Preventive Cardiology and Therapeutics Research Program, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario
    Can J Cardiol 14:1349-57. 1998
    ..The relationship between the conventional and emerging risk factors, and atherosclerosis, vascular disease and markers of end-organ damage will be evaluated between and within ethnic groups...
  3. ncbi Differences in risk factors, atherosclerosis, and cardiovascular disease between ethnic groups in Canada: the Study of Health Assessment and Risk in Ethnic groups (SHARE)
    S S Anand
    Department of Medicine, McMaster University, Ontario, Canada
    Lancet 356:279-84. 2000
    ..To establish whether this variation can be explained by differences in disease risk factors and subclinical atherosclerosis, we undertook a population-based study of three ethnic groups in Canada: South Asians, Chinese, and Europeans...
  4. ncbi Long-term oral anticoagulant therapy in patients with unstable angina or suspected non-Q-wave myocardial infarction: organization to assess strategies for ischemic syndromes (OASIS) pilot study results
    S S Anand
    From the Preventive Cardiology and Therapeutics Program, Hamilton Civics Hospital Research Centre, and Division of Cardiology, McMaster University, Hamilton, Canada
    Circulation 98:1064-70. 1998
    ..We studied the effects of long-term warfarin at 2 intensities in patients with AIS without ST elevation in 2 consecutive randomized controlled studies...
  5. ncbi Glucose levels are associated with cardiovascular disease and death in an international cohort of normal glycaemic and dysglycaemic men and women: the EpiDREAM cohort study
    S S Anand
    Population Health Research Institute, Hamilton, Ontario, Canada
    Eur J Prev Cardiol 19:755-64. 2012
    ..In an international prospective cohort study we assessed the relationship between glucose levels and incident cardiovascular events and death...
  6. ncbi Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study
    S R Mehta
    Division of Cardiology, the Population Health Research Institute and the Canadian Cardiovascular Collaboration Project Office, McMaster University, Hamilton, Canada
    Lancet 358:527-33. 2001
    ..We aimed to find out whether, in addition to aspirin, pretreatment with clopidogrel followed by long-term therapy after PCI is superior to a strategy of no pretreatment and short-term therapy for only 4 weeks after PCI...
  7. ncbi Prevalence and determinants of microalbuminuria in high-risk diabetic and nondiabetic patients in the Heart Outcomes Prevention Evaluation Study. The HOPE Study Investigators
    H C Gerstein
    McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 23:B35-9. 2000
    ....
  8. ncbi Design and rationale of CURRENT-OASIS 7: a randomized, 2 x 2 factorial trial evaluating optimal dosing strategies for clopidogrel and aspirin in patients with ST and non-ST-elevation acute coronary syndromes managed with an early invasive strategy
    Shamir R Mehta
    McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Am Heart J 156:1080-1088.e1. 2008
    ....
  9. ncbi Irbesartan in patients with atrial fibrillation
    Salim Yusuf
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    N Engl J Med 364:928-38. 2011
    ..The risk of cardiovascular events among patients with atrial fibrillation is high. We evaluated whether irbesartan, an angiotensin-receptor blocker, would reduce this risk...
  10. ncbi Stroke in relation to cardiac procedures in patients with non-ST-elevation acute coronary syndrome: a study involving >18 000 patients
    L Cronin
    Preventive Cardiology and Therapeutics Program and the Division of Cardiology, McMaster University, Hamilton, Canada
    Circulation 104:269-74. 2001
    ..95; P=0.0001). CONCLUSIONS: In this large cohort of patients with ACS, stroke was an uncommon but serious event associated with high mortality. The performance of early CABG surgery was a powerful independent predictor of stroke...
  11. ncbi Comparison of candesartan, enalapril, and their combination in congestive heart failure: randomized evaluation of strategies for left ventricular dysfunction (RESOLVD) pilot study. The RESOLVD Pilot Study Investigators
    R S McKelvie
    Hamilton Health Sciences Corporation General Division, and McMaster University, Hamilton, Ontario, Canada
    Circulation 100:1056-64. 1999
    ....
  12. ncbi Use of secondary prevention drugs for cardiovascular disease in the community in high-income, middle-income, and low-income countries (the PURE Study): a prospective epidemiological survey
    Salim Yusuf
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada
    Lancet 378:1231-43. 2011
    ....
  13. ncbi Relationship of glucose and insulin levels to the risk of myocardial infarction: a case-control study
    H C Gerstein
    Preventive Cardiology and Therapeutics Research Program, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario, Canada
    J Am Coll Cardiol 33:612-9. 1999
    ..To assess the relationship between dysglycemia and myocardial infarction in nondiabetic individuals...
  14. ncbi Rationale and design of a large study to evaluate the renal and cardiovascular effects of an ACE inhibitor and vitamin E in high-risk patients with diabetes. The MICRO-HOPE Study. Microalbuminuria, cardiovascular, and renal outcomes. Heart Outcomes Preven
    H C Gerstein
    McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 19:1225-8. 1996
    ....
  15. ncbi Risk factors, atherosclerosis, and cardiovascular disease among Aboriginal people in Canada: the Study of Health Assessment and Risk Evaluation in Aboriginal Peoples (SHARE-AP)
    S S Anand
    Preventive Cardiology and Therapeutics Research Program, Department of Medicine, McMaster University, Ontario, L8L 2X2, Hamilton, Canada
    Lancet 358:1147-53. 2001
    ..To establish the relative prevalence of risk factors, atherosclerosis, and CVD, we undertook a population-based study among people of Aboriginal and European ancestry in Canada...
  16. ncbi Apixaban in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 364:806-17. 2011
    ..Apixaban, a novel factor Xa inhibitor, may be an alternative treatment for such patients...
  17. ncbi Effects of ramipril and vitamin E on atherosclerosis: the study to evaluate carotid ultrasound changes in patients treated with ramipril and vitamin E (SECURE)
    E Lonn
    Departments of Medicine, McMaster University, Hamilton, Ontario, Canada
    Circulation 103:919-25. 2001
    ....
  18. ncbi Potentially modifiable risk factors associated with myocardial infarction in China: the INTERHEART China study
    K K Teo
    Population Health Research Institute, McMaster University Hamilton Health Sciences, Hamilton, Ontario, Canada
    Heart 95:1857-64. 2009
    ..Lifestyle changes associated with the rapidly developing economy increase cardiovascular disease (CVD), myocardial infarction (MI) and cardiovascular risk factors (CVRFs) in China...
  19. ncbi Comparison of the anticoagulant intensities of fondaparinux and enoxaparin in the Organization to Assess Strategies in Acute Ischemic Syndromes (OASIS)-5 trial
    J A M Anderson
    Division of Hematology, and Cardiology, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    J Thromb Haemost 8:243-9. 2010
    ..The mechanism of lower bleeding and improved efficacy with fondaparinux is uncertain...
  20. ncbi Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals
    H C Gerstein
    Department of Medicine, Room 3V38, 1200 Main St W, Hamilton, Ontario, L8N 3Z5
    JAMA 286:421-6. 2001
    ..Microalbuminuria is a risk factor for cardiovascular (CV) events. The relationship between the degree of albuminuria and CV risk is unclear...
  21. ncbi Rationale and design of ACTIVE: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events
    S Connolly
    Population Health Research Institute, Hamilton, Ontario, Canada
    Am Heart J 151:1187-93. 2006
    ..Irbesartan is an angiotensin receptor-blocking agent that reduces blood pressure and has other vascular protective effects...
  22. ncbi Design, history and results of the Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) randomised controlled trial
    Z Punthakee
    Population Health Research Institute, McMaster University, 237 Barton St E, Hamilton, ON, Canada, L8L 2X2
    Diabetologia 55:36-45. 2012
    ....
  23. ncbi Anthropometric measures and glucose levels in a large multi-ethnic cohort of individuals at risk of developing type 2 diabetes
    L de Koning
    The Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    Diabetologia 53:1322-30. 2010
    ..We also explored variation in anthropometric associations by sex and ethnicity...
  24. ncbi Dysglycaemia and the risk of acute myocardial infarction in multiple ethnic groups: an analysis of 15,780 patients from the INTERHEART study
    H C Gerstein
    The Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada
    Diabetologia 53:2509-17. 2010
    ..Although diabetes is an established risk factor for myocardial infarction (MI), disease control may vary. HbA(1c) is a reliable index of ambient glucose levels and may provide more information on MI risk than diabetes status...
  25. ncbi Prognostic significance of thrombocytopenia during hirudin and heparin therapy in acute coronary syndrome without ST elevation: Organization to Assess Strategies for Ischemic Syndromes (OASIS-2)study
    J W Eikelboom
    Preventive Cardiology and Therapeutics Program, McMaster University, Hamilton, Canada
    Circulation 103:643-50. 2001
    ..The excess of major bleeding in hirudin-treated patients who develop thrombocytopenia suggests that thrombocytopenia may contribute to the increased risk of bleeding observed with hirudin...
  26. ncbi Impact of right ventricular involvement on mortality and morbidity in patients with inferior myocardial infarction
    S R Mehta
    Division of Cardiology, Hamilton Health Sciences Corporation, McMaster University, Ontario, Canada
    J Am Coll Cardiol 37:37-43. 2001
    ..We sought to evaluate the prognostic impact of right ventricular (RV) myocardial involvement in patients with inferior myocardial infarction (MI)...
  27. ncbi Telmisartan, ramipril, or both in patients at high risk for vascular events
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 358:1547-59. 2008
    ..We compared the ACE inhibitor ramipril, the ARB telmisartan, and the combination of the two drugs in patients with vascular disease or high-risk diabetes...
  28. ncbi The Prospective Urban Rural Epidemiology (PURE) study: examining the impact of societal influences on chronic noncommunicable diseases in low-, middle-, and high-income countries
    Koon Teo
    Population Health Research Institute, McMaster University Hamilton Health Sciences, Hamilton, Ontario, Canada
    Am Heart J 158:1-7.e1. 2009
    ..The overarching aim of the study is to examine the relationship of societal influences on human lifestyle behaviors, cardiovascular risk factors, and incidence of chronic noncommunicable diseases...
  29. ncbi The HOPE (Heart Outcomes Prevention Evaluation) Study and its consequences
    M J McQueen
    Hamilton Regional Laboratory Medicine Program, Department of Laboratory Medicine, St Joseph s Hospital, Hamilton, Ontario
    Scand J Clin Lab Invest Suppl 240:143-56. 2005
    ..Sub-studies completed and on-going into the predictive role of natriuretic peptides, infectious and inflammatory markers, provide insight into possible mechanisms of action of Ramipril...
  30. ncbi Telmisartan to prevent recurrent stroke and cardiovascular events
    Salim Yusuf
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    N Engl J Med 359:1225-37. 2008
    ..We evaluated the effects of therapy with an angiotensin-receptor blocker, telmisartan, initiated early after a stroke...
  31. ncbi Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial
    Shamir R Mehta
    McMaster University and Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    Lancet 376:1233-43. 2010
    ..We assessed the effect of various clopidogrel and aspirin regimens in prevention of major cardiovascular events and stent thrombosis in patients undergoing PCI...
  32. ncbi The relationship between dysglycaemia and cardiovascular and renal risk in diabetic and non-diabetic participants in the HOPE study: a prospective epidemiological analysis
    H C Gerstein
    McMaster University and Population Health Research Institute, Hamilton, Ontario, Canada
    Diabetologia 48:1749-55. 2005
    ....
  33. ncbi Enalapril prevents clinical proteinuria in diabetic patients with low ejection fraction
    S E Capes
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 23:377-80. 2000
    ..The prevalence of clinical proteinuria, its correlates and predictive value, and the effect of ACE inhibitors in preventing clinical proteinuria in diabetic and nondiabetic patients with left ventricular (LV) dysfunction are unknown...
  34. ncbi Low rates of preventive practices in patients with peripheral vascular disease
    S S Anand
    Hamilton Civic Hospitals Research Centre, McMaster University, Hamilton, Canada
    Can J Cardiol 15:1259-63. 1999
    ..Given the scarcity of data on the preventive practice patterns of this high risk patient group, the in-hospital management of patients admitted to hospital for a peripheral vascular intervention was reviewed...
  35. ncbi Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial
    Sanjit S Jolly
    McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    Lancet 377:1409-20. 2011
    ..We aimed to assess whether radial access was superior to femoral access in patients with acute coronary syndromes (ACS) who were undergoing coronary angiography with possible intervention...
  36. ncbi Safety outcomes in meta-analyses of phase 2 vs phase 3 randomized trials: Intracranial hemorrhage in trials of bolus thrombolytic therapy
    J W Eikelboom
    McMaster University, Hamilton General Hospital McMaster Clinic, 237 Barton St E, Hamilton, Ontario, Canada L8L 2X2
    JAMA 285:444-50. 2001
    ..Recent studies have reported disagreement between meta-analysis of small trials and subsequent large trials addressing the same question. However, disagreement for uncommon but serious adverse safety outcomes has not been examined...
  37. ncbi Oral anticoagulant therapy in patients with coronary artery disease: a meta-analysis
    S S Anand
    Program of Preventive Cardiology and Therapeutics, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario, Canada
    JAMA 282:2058-67. 1999
    ..Despite years of use in coronary artery disease (CAD) and several studies of its effectiveness, the role of oral anticoagulants (OAs) remains controversial...
  38. ncbi Reliability, validity, and responsiveness of the six-minute walk test in patients with heart failure
    C Demers
    Preventive Cardiology and Therapeutics Research Program, Division of Cardiology, Hamilton Health Sciences Corporation-General Division and McMaster University, Hamilton, Ontario, Canada
    Am Heart J 142:698-703. 2001
    ..It is somewhat correlated to NYHA-FC and quality of life. Overall, quality of life was most responsive to change, whereas 6MWT and NYHA-FC were comparable but less responsive to change in the RESOLVD study...
  39. ncbi Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study
    MARTIN J O'DONNELL
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    Lancet 376:112-23. 2010
    ....
  40. ncbi Dabigatran versus warfarin in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 361:1139-51. 2009
    ..Warfarin reduces the risk of stroke in patients with atrial fibrillation but increases the risk of hemorrhage and is difficult to use. Dabigatran is a new oral direct thrombin inhibitor...
  41. ncbi Ramipril and the development of diabetes
    S Yusuf
    Canadian Cardiovascular Collaboration Project Office, Hamilton General Hospital, 237 Barton St East, Hamilton, Ontario, Canada L8L 2X2
    JAMA 286:1882-5. 2001
    ..Type 2 diabetes is a growing clinical and public health problem. Preventive efforts related to lifestyle modification are not always successful; therefore, alternative prevention strategies need to be studied...
  42. ncbi INTER-HEART: A global study of risk factors for acute myocardial infarction
    S Ounpuu
    Canadian Cardiovascular Collaboration, McMaster University, Canada
    Am Heart J 141:711-21. 2001
    ..This has ensured the feasibility of INTER-HEART. This study has the potential to have a major impact in developing a worldwide strategy for cardiovascular disease prevention, especially in developing countries and nonwhite populations...
  43. ncbi Increased cardiovascular risk after pre-eclampsia in women with dysglycaemia
    S D McDonald
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada
    Diabet Med 30:e1-7. 2013
    ..Our objective was to determine if the high risk of cardiovascular disease in women with pre-eclampsia is accounted for by known cardiovascular risk factors including albuminuria...
  44. ncbi Validity of the US Behavioral Risk Factor Surveillance System's health related quality of life survey tool in a group of older Canadians
    S Ounpuu
    Population Health Section, Hamilton General Hospital, McMaster Clinic and Department of Medicine, McMaster University, 237 Barton Street East, Hamilton, Ontario L8L 2X2
    Chronic Dis Can 22:93-101. 2001
    ..This study demonstrated that the HRQOL-4 is not only accepted by older adults in a self-administered format, but also stands up to tests of its validity...
  45. ncbi Relationship of current and past smoking to mortality and morbidity in patients with left ventricular dysfunction
    N Suskin
    Division of Cardiology, London Health Science Center, Ontario, Canada
    J Am Coll Cardiol 37:1677-82. 2001
    ....
  46. ncbi Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization
    S Yusuf
    Population Health Research Institute and Division of Cardiology, McMaster University, Hamilton, Ontario, Canada
    Circulation 104:2746-53. 2001
    ..Part II of this article describes the burden of CV disease by specific region or ethnic group, the risk factors of importance, and possible strategies for prevention...
  47. ncbi Cardiovascular risk factors and non-invasive assessment of subclinical atherosclerosis in youth
    K M Morrison
    Mc Master University, HSC 3A59, 1200 Main Street W, Hamilton, ON, L8N 3Z5, Canada
    Atherosclerosis 208:501-5. 2010
    ..The age at which vascular changes can be reliably identified using IMT and the influence of CV risk factors beyond FH on IMT remains unclear...
  48. ncbi Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial
    S Connolly
    Health Research Institute, Hamilton, ON, Canada
    Lancet 367:1903-12. 2006
    ..However, long-term monitoring is necessary and many patients cannot achieve optimum anticoagulation. We assessed whether clopidogrel plus aspirin was non-inferior to oral anticoagulation therapy for prevention of vascular events...
  49. ncbi Early versus delayed invasive intervention in acute coronary syndromes
    Shamir R Mehta
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 360:2165-75. 2009
    ..Earlier trials have shown that a routine invasive strategy improves outcomes in patients with acute coronary syndromes without ST-segment elevation. However, the optimal timing of such intervention remains uncertain...
  50. ncbi Global burden of cardiovascular diseases: Part II: variations in cardiovascular disease by specific ethnic groups and geographic regions and prevention strategies
    S Yusuf
    Population Health Research Institute and Division of Cardiology, McMaster University, Hamilton, Ontario, Canada
    Circulation 104:2855-64. 2001
    ..Part II of this article describes the burden of CV disease by specific region or ethnic group, the risk factors of importance, and possible strategies for prevention...
  51. ncbi Rationale, design and baseline characteristics of a large, simple, randomized trial of combined folic acid and vitamins B6 and B12 in high-risk patients: the Heart Outcomes Prevention Evaluation (HOPE)-2 trial
    E Lonn
    Hamilton Health Sciences Corporation, Hamilton, Ontario
    Can J Cardiol 22:47-53. 2006
    ..Therefore, a large, randomized clinical trial--the Heart Outcomes Prevention Evaluation (HOPE)-2 study--is being conducted to evaluate this therapy in patients at high risk for CV events...
  52. ncbi The evolution of the randomized controlled trial and its role in evidence-based decision making
    P J Devereaux
    Department of Medicine and Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    J Intern Med 254:105-13. 2003
    ..We discuss the role of the randomized controlled trial within evidence-based decision making...
  53. ncbi Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
    S Yusuf
    Canadian Cardiovascular Collaboration Project Office, Hamilton General Hospital, McMaster University, ON
    N Engl J Med 342:145-53. 2000
    ..We assessed the role of an angiotensin-converting-enzyme inhibitor, ramipril, in patients who were at high risk for cardiovascular events but who did not have left ventricular dysfunction or heart failure...
  54. ncbi Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
    S Yusuf
    Canadian Cardiovascular Collaboration Project Office, Hamilton General Hospital, ON
    N Engl J Med 342:154-60. 2000
    ..Observational and experimental studies suggest that the amount of vitamin E ingested in food and in supplements is associated with a lower risk of coronary heart disease and atherosclerosis...
  55. ncbi Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample
    Matthew B Lanktree
    Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    J Lipid Res 50:1487-96. 2009
    ..The findings indicate the potential utility of the Illumina CVD beadchip, but they underscore the need to consider meta-analysis of results from commonly studied clinical or epidemiological samples...
  56. ncbi Effects of physiologic pacing versus ventricular pacing on the risk of stroke and death due to cardiovascular causes. Canadian Trial of Physiologic Pacing Investigators
    S J Connolly
    Department of Medicine, McMaster University, Hamilton, Ont, Canada
    N Engl J Med 342:1385-91. 2000
    ..These benefits have not been evaluated in a large, randomized, controlled trial...
  57. ncbi Previous exposure to Chlamydia pneumoniae, Helicobacter pylori and other infections in Canadian patients with ischemic heart disease
    M Smieja
    St Joseph's Hospital, Hamilton, Canada
    Can J Cardiol 17:270-6. 2001
    ..A prospective validation of this association is needed...
  58. ncbi Efficacy of hirudin in reducing cardiovascular events in patients with acute coronary syndrome undergoing early percutaneous coronary intervention
    S R Mehta
    Division of Cardiology, Hamilton Health Sciences Corporation, McMaster University Medical Center, 1200 Main Street West, HSC 3U5, Hamilton, Ontario, Canada L8N 3Z5
    Eur Heart J 23:117-23. 2002
    ....
  59. ncbi Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial
    P J Devereaux
    McMaster University, Faculty of Health Sciences, Clinical Epidemiology and Biostatistics, Room 2C8, 1200 Main Street West, Hamilton, ON, L8N 3Z5, Canada
    Lancet 371:1839-47. 2008
    ..This randomised controlled trial, done in 190 hospitals in 23 countries, was designed to investigate the effects of perioperative beta blockers...
  60. ncbi Recurrent events in meta-analysis of multiple clinical trials
    Y Wang
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada Robertson
    Zhongguo Yao Li Xue Bao 20:495-9. 1999
    ..To study the efficacy and safety of drug or therapy with recurrent events in meta-analysis of multiple clinical trials...
  61. ncbi Is there a role for antioxidant vitamins in the prevention of cardiovascular diseases? An update on epidemiological and clinical trials data
    E M Lonn
    Division of Cardiology, McMaster University, Hamilton, Ontario
    Can J Cardiol 13:957-65. 1997
    ..To review prospective epidemiological studies and randomized clinical trials regarding the role of antioxidant vitamins (vitamins E and C and beta-carotene) in the prevention of cardiovascular diseases...
  62. ncbi Ethnic differences in the relationships between obesity and glucose-metabolic abnormalities: a cross-sectional population-based study
    F Razak
    Population Health Research Institute, McMaster University, Hamilton General Hospital, Hamilton, ON, Canada
    Int J Obes (Lond) 29:656-67. 2005
    ..Existing action thresholds for these anthropometric indices do not apply to non-European ethnic groups and warrant revision...
  63. ncbi The 2002/3 Canadian Cardiovascular Society consensus guideline update for the diagnosis and management of heart failure
    P Liu
    Heart and Stroke/RL Centre of Excellence, Toronto General Hospital, Ontario, Canada
    Can J Cardiol 19:347-56. 2003
  64. ncbi Risk of hospitalization during influenza season among a cohort of patients with congestive heart failure
    C Sandoval
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Epidemiol Infect 135:574-82. 2007
    ..98-1.24, P=0.11). Patients with CHF have a greater risk of hospitalization during the influenza season than in the non-influenza season, supporting the current belief that patients with CHF should be regarded as a high-risk group...
  65. ncbi Rationale and design of INTERSTROKE: a global case-control study of risk factors for stroke
    M O'DONNELL
    Population Health Research Group, McMaster University, Hamilton, ON L8L 2X2, Canada
    Neuroepidemiology 35:36-44. 2010
    ..Study Significance: An effective global strategy to reduce the risk of stroke mandates systematic measurement of the contribution of the major vascular risk factors within defined ethnic groups and geographical locations...
  66. ncbi Rationale, design and recruitment characteristics of a large, simple international trial of diabetes prevention: the DREAM trial
    H C Gerstein
    Population Health Research Institute, Hamilton, Ontario, Canada
    Diabetologia 47:1519-27. 2004
    ..This risk can be reduced by lifestyle changes and/or various drugs. Novel therapies to prevent diabetes, as well as new risk factors for diabetes, atherosclerosis and obesity require testing and identification...
  67. ncbi Clinical features and contemporary management of patients with low and preserved ejection fraction heart failure: baseline characteristics of patients in the Candesartan in Heart failure-Assessment of Reduction in Mortality and morbidity (CHARM) programme
    J McMurray
    Department of Cardiology, Western Infirmary, University of Glasgow, Glasgow G11 6NT, Scotland, UK
    Eur J Heart Fail 5:261-70. 2003
    ....
  68. ncbi Renal insufficiency as a predictor of cardiovascular outcomes and the impact of ramipril: the HOPE randomized trial
    J F Mann
    Department of Nephrology and Hypertension, Schwabing General Hospital, LMU, Kolner Platz 1, D-80804 Munchen, Germany
    Ann Intern Med 134:629-36. 2001
    ..Ramipril reduced cardiovascular risk without increasing adverse effects...
  69. ncbi Impact of ramipril in patients with evidence of clinical or subclinical peripheral arterial disease
    J Ostergren
    Department of Medicine, Division of Emergency Medicine, Karolinska Hospital, 171 76 Stockholm, Sweden
    Eur Heart J 25:17-24. 2004
    ....
  70. ncbi Glucose levels predict hospitalization for congestive heart failure in patients at high cardiovascular risk
    C Held
    Karolinska Institutet, Department of Medicine, Unit of Cardiology, Karolinska University Hospital, 17176 Stockholm, Sweden
    Circulation 115:1371-5. 2007
    ..Patients with diabetes mellitus (DM) are at high risk of developing congestive heart failure (CHF). However, the relationships between glucose levels and CHF in people with or without a history of DM have not been well characterized...
  71. ncbi Venous thromboembolism in association with features of the metabolic syndrome
    J G Ray
    Department of Medicine, St Michael s Hospital, University of Toronto, Ontario M5B 1W8, Canada
    QJM 100:679-84. 2007
    ..However, whether each of these factors additively increases the risk of VTE is uncertain...
  72. ncbi Effects of ramipril and rosiglitazone on cardiovascular and renal outcomes in people with impaired glucose tolerance or impaired fasting glucose: results of the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) trial
    G R Dagenais
    Laval University Heart and Lung Institute, 2725 Chemin Ste Foy, Quebec, Quebec City, Canada
    Diabetes Care 31:1007-14. 2008
    ..We determined the effects of ramipril and rosiglitazone on combined and individual CVD and renal outcomes in people with IGT and/or IFG in the Diabetes REduction Assessment With ramipril and rosiglitazone Medication (DREAM) trial...
  73. ncbi Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial
    H C Gerstein
    Lancet 368:1096-105. 2006
    ....
  74. ncbi Correction to the PRoFESS Trial paper by Diener et al. (Cerebrovasc Dis 2007;23:368-80
    R Sacco
    Cerebrovasc Dis 25:192. 2008
  75. ncbi Effects of intensive glucose lowering in type 2 diabetes
    Hertzel C Gerstein
    N Engl J Med 358:2545-59. 2008
    ..These findings identify a previously unrecognized harm of intensive glucose lowering in high-risk patients with type 2 diabetes. (ClinicalTrials.gov number, NCT00000620.)..
  76. ncbi Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke
    Ralph L Sacco
    Miller School of Medicine, University of Miami, Miami, USA
    N Engl J Med 359:1238-51. 2008
    ..Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens--aspirin plus extended-release dipyridamole (ASA-ERDP) versus clopidogrel...
  77. ncbi Prevalence and prognostic implications of electrocardiographic left ventricular hypertrophy in heart failure: evidence from the CHARM programme
    N M Hawkins
    Department of Cardiology, Stobhill Hospital, Balornock Road, Springburn, Glasgow G21 3UW, UK
    Heart 93:59-64. 2007
    ..Electrocardiographic left ventricular hypertrophy (ECG LVH) is a powerful independent predictor of cardiovascular morbidity and mortality in hypertension...
  78. ncbi Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: a randomised controlled trial
    S Yusuf
    Lancet 372:1174-83. 2008
    ..FUNDING: Boehringer Ingelheim...
  79. ncbi Clopidogrel does not suppress blood markers of coagulation activation in aspirin-treated patients with non-ST-elevation acute coronary syndromes
    J W Eikelboom
    Thrombosis and Haemophilia Unit, Royal Perth Hospital, Perth, Australia
    Eur Heart J 23:1771-9. 2002
    ..The persistence of thrombin generation despite long-term clopidogrel and aspirin therapy suggests that even more intensive antithrombotic therapy may be required in these patients...
  80. ncbi Singapore and coronary heart disease: a population laboratory to explore ethnic variations in the epidemiologic transition
    S Ounpuu
    Eur Heart J 24:127-9. 2003
  81. ncbi Effects of different regimens to lower blood pressure on major cardiovascular events in older and younger adults: meta-analysis of randomised trials
    F Turnbull
    George Institute for International Health, University of Sydney, PO Box M201, Sydney, NSW 2050, Australia
    BMJ 336:1121-3. 2008
    ..To quantify the relative risk reductions achieved with different regimens to lower blood pressure in younger and older adults...
  82. ncbi Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisation
    J Danesh
    Eur J Epidemiol 23:531-40. 2008
    ..This work should advance understanding of the relevance of low-grade inflammation to CHD and indicate whether or not CRP itself is involved in long-term pathogenesis...
  83. ncbi Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: the BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT)
    Jose Antonio Marin-Neto
    Medical School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Am Heart J 156:37-43. 2008
    ..However, the efficacy of trypanocidal therapy in preventing clinical complications in patients with preexisting cardiac disease is unknown...
  84. ncbi A cardiologist's guide to waist management
    A Merchant
    Heart 92:865-6. 2006
    ..Clinical management of obesity remains a challenge...