S Yusuf

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint The global epidemic of atherosclerotic cardiovascular disease
    Salim Yusuf
    Population Health Research Institute and Division of Cardiology, McMaster University, Hamilton, Ont, Canada
    Med Princ Pract 11:3-8. 2002
  2. ncbi request reprint Choice of clinical outcomes in randomized trials of heart failure therapies: disease-specific or overall outcomes?
    Salim Yusuf
    Division of Cardiology, McMaster University, and the Preventive Cardiology and Therapeutics Program, Hamilton Health Sciences Corporation, Hamilton, Ontario, Canada
    Am Heart J 143:22-8. 2002
  3. ncbi request reprint Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
    S Yusuf
    Canadian Cardiovascular Collaboration Project Office, Hamilton General Hospital, ON
    N Engl J Med 342:154-60. 2000
  4. ncbi request reprint The Study of Health Assessment and Risk in Ethnic groups (SHARE): rationale and design. The SHARE Investigators
    S S Anand
    Preventive Cardiology and Therapeutics Research Program, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario
    Can J Cardiol 14:1349-57. 1998
  5. ncbi request reprint Differences in risk factors, atherosclerosis, and cardiovascular disease between ethnic groups in Canada: the Study of Health Assessment and Risk in Ethnic groups (SHARE)
    S S Anand
    Department of Medicine, McMaster University, Ontario, Canada
    Lancet 356:279-84. 2000
  6. ncbi request reprint Long-term oral anticoagulant therapy in patients with unstable angina or suspected non-Q-wave myocardial infarction: organization to assess strategies for ischemic syndromes (OASIS) pilot study results
    S S Anand
    From the Preventive Cardiology and Therapeutics Program, Hamilton Civics Hospital Research Centre, and Division of Cardiology, McMaster University, Hamilton, Canada
    Circulation 98:1064-70. 1998
  7. doi request reprint Glucose levels are associated with cardiovascular disease and death in an international cohort of normal glycaemic and dysglycaemic men and women: the EpiDREAM cohort study
    S S Anand
    Population Health Research Institute, Hamilton, Ontario, Canada
    Eur J Prev Cardiol 19:755-64. 2012
  8. ncbi request reprint Variations between countries in invasive cardiac procedures and outcomes in patients with suspected unstable angina or myocardial infarction without initial ST elevation. OASIS (Organisation to Assess Strategies for Ischaemic Syndromes) Registry Investiga
    S Yusuf
    McMaster University, Hamilton, Ontario, Canada
    Lancet 352:507-14. 1998
  9. ncbi request reprint Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study
    S R Mehta
    Division of Cardiology, the Population Health Research Institute and the Canadian Cardiovascular Collaboration Project Office, McMaster University, Hamilton, Canada
    Lancet 358:527-33. 2001
  10. doi request reprint Design and rationale of CURRENT-OASIS 7: a randomized, 2 x 2 factorial trial evaluating optimal dosing strategies for clopidogrel and aspirin in patients with ST and non-ST-elevation acute coronary syndromes managed with an early invasive strategy
    Shamir R Mehta
    McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Am Heart J 156:1080-1088.e1. 2008

Collaborators

Detail Information

Publications130 found, 100 shown here

  1. ncbi request reprint The global epidemic of atherosclerotic cardiovascular disease
    Salim Yusuf
    Population Health Research Institute and Division of Cardiology, McMaster University, Hamilton, Ont, Canada
    Med Princ Pract 11:3-8. 2002
    ..The latter involves societal level changes including laws that curb the use of tobacco, and strategies that promote physical activities, and appropriate nutrition...
  2. ncbi request reprint Choice of clinical outcomes in randomized trials of heart failure therapies: disease-specific or overall outcomes?
    Salim Yusuf
    Division of Cardiology, McMaster University, and the Preventive Cardiology and Therapeutics Program, Hamilton Health Sciences Corporation, Hamilton, Ontario, Canada
    Am Heart J 143:22-8. 2002
    ..There are different views regarding the appropriateness of using cause-specific events or all events as the primary outcome of clinical trials...
  3. ncbi request reprint Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
    S Yusuf
    Canadian Cardiovascular Collaboration Project Office, Hamilton General Hospital, ON
    N Engl J Med 342:154-60. 2000
    ..Observational and experimental studies suggest that the amount of vitamin E ingested in food and in supplements is associated with a lower risk of coronary heart disease and atherosclerosis...
  4. ncbi request reprint The Study of Health Assessment and Risk in Ethnic groups (SHARE): rationale and design. The SHARE Investigators
    S S Anand
    Preventive Cardiology and Therapeutics Research Program, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario
    Can J Cardiol 14:1349-57. 1998
    ..The relationship between the conventional and emerging risk factors, and atherosclerosis, vascular disease and markers of end-organ damage will be evaluated between and within ethnic groups...
  5. ncbi request reprint Differences in risk factors, atherosclerosis, and cardiovascular disease between ethnic groups in Canada: the Study of Health Assessment and Risk in Ethnic groups (SHARE)
    S S Anand
    Department of Medicine, McMaster University, Ontario, Canada
    Lancet 356:279-84. 2000
    ..To establish whether this variation can be explained by differences in disease risk factors and subclinical atherosclerosis, we undertook a population-based study of three ethnic groups in Canada: South Asians, Chinese, and Europeans...
  6. ncbi request reprint Long-term oral anticoagulant therapy in patients with unstable angina or suspected non-Q-wave myocardial infarction: organization to assess strategies for ischemic syndromes (OASIS) pilot study results
    S S Anand
    From the Preventive Cardiology and Therapeutics Program, Hamilton Civics Hospital Research Centre, and Division of Cardiology, McMaster University, Hamilton, Canada
    Circulation 98:1064-70. 1998
    ..We studied the effects of long-term warfarin at 2 intensities in patients with AIS without ST elevation in 2 consecutive randomized controlled studies...
  7. doi request reprint Glucose levels are associated with cardiovascular disease and death in an international cohort of normal glycaemic and dysglycaemic men and women: the EpiDREAM cohort study
    S S Anand
    Population Health Research Institute, Hamilton, Ontario, Canada
    Eur J Prev Cardiol 19:755-64. 2012
    ..In an international prospective cohort study we assessed the relationship between glucose levels and incident cardiovascular events and death...
  8. ncbi request reprint Variations between countries in invasive cardiac procedures and outcomes in patients with suspected unstable angina or myocardial infarction without initial ST elevation. OASIS (Organisation to Assess Strategies for Ischaemic Syndromes) Registry Investiga
    S Yusuf
    McMaster University, Hamilton, Ontario, Canada
    Lancet 352:507-14. 1998
    ....
  9. ncbi request reprint Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study
    S R Mehta
    Division of Cardiology, the Population Health Research Institute and the Canadian Cardiovascular Collaboration Project Office, McMaster University, Hamilton, Canada
    Lancet 358:527-33. 2001
    ..We aimed to find out whether, in addition to aspirin, pretreatment with clopidogrel followed by long-term therapy after PCI is superior to a strategy of no pretreatment and short-term therapy for only 4 weeks after PCI...
  10. doi request reprint Design and rationale of CURRENT-OASIS 7: a randomized, 2 x 2 factorial trial evaluating optimal dosing strategies for clopidogrel and aspirin in patients with ST and non-ST-elevation acute coronary syndromes managed with an early invasive strategy
    Shamir R Mehta
    McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Am Heart J 156:1080-1088.e1. 2008
    ....
  11. ncbi request reprint Prevalence and determinants of microalbuminuria in high-risk diabetic and nondiabetic patients in the Heart Outcomes Prevention Evaluation Study. The HOPE Study Investigators
    H C Gerstein
    McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 23:B35-9. 2000
    ....
  12. doi request reprint Use of secondary prevention drugs for cardiovascular disease in the community in high-income, middle-income, and low-income countries (the PURE Study): a prospective epidemiological survey
    Salim Yusuf
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada
    Lancet 378:1231-43. 2011
    ....
  13. doi request reprint Irbesartan in patients with atrial fibrillation
    Salim Yusuf
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    N Engl J Med 364:928-38. 2011
    ..The risk of cardiovascular events among patients with atrial fibrillation is high. We evaluated whether irbesartan, an angiotensin-receptor blocker, would reduce this risk...
  14. ncbi request reprint Risk factors, atherosclerosis, and cardiovascular disease among Aboriginal people in Canada: the Study of Health Assessment and Risk Evaluation in Aboriginal Peoples (SHARE-AP)
    S S Anand
    Preventive Cardiology and Therapeutics Research Program, Department of Medicine, McMaster University, Ontario, L8L 2X2, Hamilton, Canada
    Lancet 358:1147-53. 2001
    ..To establish the relative prevalence of risk factors, atherosclerosis, and CVD, we undertook a population-based study among people of Aboriginal and European ancestry in Canada...
  15. ncbi request reprint Rationale and design of ACTIVE: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events
    S Connolly
    Population Health Research Institute, Hamilton, Ontario, Canada
    Am Heart J 151:1187-93. 2006
    ..Irbesartan is an angiotensin receptor-blocking agent that reduces blood pressure and has other vascular protective effects...
  16. doi request reprint Apixaban in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 364:806-17. 2011
    ..Apixaban, a novel factor Xa inhibitor, may be an alternative treatment for such patients...
  17. doi request reprint Increased cardiovascular risk after pre-eclampsia in women with dysglycaemia
    S D McDonald
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada
    Diabet Med 30:e1-7. 2013
    ..Our objective was to determine if the high risk of cardiovascular disease in women with pre-eclampsia is accounted for by known cardiovascular risk factors including albuminuria...
  18. ncbi request reprint Relationship of glucose and insulin levels to the risk of myocardial infarction: a case-control study
    H C Gerstein
    Preventive Cardiology and Therapeutics Research Program, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario, Canada
    J Am Coll Cardiol 33:612-9. 1999
    ..To assess the relationship between dysglycemia and myocardial infarction in nondiabetic individuals...
  19. ncbi request reprint Comparison of candesartan, enalapril, and their combination in congestive heart failure: randomized evaluation of strategies for left ventricular dysfunction (RESOLVD) pilot study. The RESOLVD Pilot Study Investigators
    R S McKelvie
    Hamilton Health Sciences Corporation General Division, and McMaster University, Hamilton, Ontario, Canada
    Circulation 100:1056-64. 1999
    ....
  20. ncbi request reprint Rationale and design of a large study to evaluate the renal and cardiovascular effects of an ACE inhibitor and vitamin E in high-risk patients with diabetes. The MICRO-HOPE Study. Microalbuminuria, cardiovascular, and renal outcomes. Heart Outcomes Preven
    H C Gerstein
    McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 19:1225-8. 1996
    ....
  21. ncbi request reprint Effects of ramipril and vitamin E on atherosclerosis: the study to evaluate carotid ultrasound changes in patients treated with ramipril and vitamin E (SECURE)
    E Lonn
    Departments of Medicine, McMaster University, Hamilton, Ontario, Canada
    Circulation 103:919-25. 2001
    ....
  22. ncbi request reprint Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
    S Yusuf
    Canadian Cardiovascular Collaboration Project Office, Hamilton General Hospital, McMaster University, ON
    N Engl J Med 342:145-53. 2000
    ..We assessed the role of an angiotensin-converting-enzyme inhibitor, ramipril, in patients who were at high risk for cardiovascular events but who did not have left ventricular dysfunction or heart failure...
  23. ncbi request reprint Ethnic differences in the relationships between obesity and glucose-metabolic abnormalities: a cross-sectional population-based study
    F Razak
    Population Health Research Institute, McMaster University, Hamilton General Hospital, Hamilton, ON, Canada
    Int J Obes (Lond) 29:656-67. 2005
    ..To evaluate whether body mass index (BMI) and other anthropometric indices of visceral obesity vary by ethnic group in their distribution and their relationship to metabolic abnormalities...
  24. pmc Telmisartan to prevent recurrent stroke and cardiovascular events
    Salim Yusuf
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    N Engl J Med 359:1225-37. 2008
    ..We evaluated the effects of therapy with an angiotensin-receptor blocker, telmisartan, initiated early after a stroke...
  25. ncbi request reprint Anthropometric measures and glucose levels in a large multi-ethnic cohort of individuals at risk of developing type 2 diabetes
    L de Koning
    The Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    Diabetologia 53:1322-30. 2010
    ..We also explored variation in anthropometric associations by sex and ethnicity...
  26. doi request reprint The Prospective Urban Rural Epidemiology (PURE) study: examining the impact of societal influences on chronic noncommunicable diseases in low-, middle-, and high-income countries
    Koon Teo
    Population Health Research Institute, McMaster University Hamilton Health Sciences, Hamilton, Ontario, Canada
    Am Heart J 158:1-7.e1. 2009
    ..The overarching aim of the study is to examine the relationship of societal influences on human lifestyle behaviors, cardiovascular risk factors, and incidence of chronic noncommunicable diseases...
  27. ncbi request reprint Potentially modifiable risk factors associated with myocardial infarction in China: the INTERHEART China study
    K K Teo
    Population Health Research Institute, McMaster University Hamilton Health Sciences, Hamilton, Ontario, Canada
    Heart 95:1857-64. 2009
    ..Lifestyle changes associated with the rapidly developing economy increase cardiovascular disease (CVD), myocardial infarction (MI) and cardiovascular risk factors (CVRFs) in China...
  28. ncbi request reprint The HOPE (Heart Outcomes Prevention Evaluation) Study and its consequences
    M J McQueen
    Hamilton Regional Laboratory Medicine Program, Department of Laboratory Medicine, St Joseph s Hospital, Hamilton, Ontario
    Scand J Clin Lab Invest Suppl 240:143-56. 2005
    ..Sub-studies completed and on-going into the predictive role of natriuretic peptides, infectious and inflammatory markers, provide insight into possible mechanisms of action of Ramipril...
  29. ncbi request reprint Stroke in relation to cardiac procedures in patients with non-ST-elevation acute coronary syndrome: a study involving >18 000 patients
    L Cronin
    Preventive Cardiology and Therapeutics Program and the Division of Cardiology, McMaster University, Hamilton, Canada
    Circulation 104:269-74. 2001
    ..95; P=0.0001). CONCLUSIONS: In this large cohort of patients with ACS, stroke was an uncommon but serious event associated with high mortality. The performance of early CABG surgery was a powerful independent predictor of stroke...
  30. doi request reprint Comparison of the anticoagulant intensities of fondaparinux and enoxaparin in the Organization to Assess Strategies in Acute Ischemic Syndromes (OASIS)-5 trial
    J A M Anderson
    Division of Hematology, and Cardiology, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    J Thromb Haemost 8:243-9. 2010
    ..The mechanism of lower bleeding and improved efficacy with fondaparinux is uncertain...
  31. ncbi request reprint Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals
    H C Gerstein
    Department of Medicine, Room 3V38, 1200 Main St W, Hamilton, Ontario, L8N 3Z5
    JAMA 286:421-6. 2001
    ..Microalbuminuria is a risk factor for cardiovascular (CV) events. The relationship between the degree of albuminuria and CV risk is unclear...
  32. doi request reprint Telmisartan, ramipril, or both in patients at high risk for vascular events
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 358:1547-59. 2008
    ..We compared the ACE inhibitor ramipril, the ARB telmisartan, and the combination of the two drugs in patients with vascular disease or high-risk diabetes...
  33. doi request reprint Design, history and results of the Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) randomised controlled trial
    Z Punthakee
    Population Health Research Institute, McMaster University, 237 Barton St E, Hamilton, ON, Canada, L8L 2X2
    Diabetologia 55:36-45. 2012
    ....
  34. ncbi request reprint The relationship between dysglycaemia and cardiovascular and renal risk in diabetic and non-diabetic participants in the HOPE study: a prospective epidemiological analysis
    H C Gerstein
    McMaster University and Population Health Research Institute, Hamilton, Ontario, Canada
    Diabetologia 48:1749-55. 2005
    ....
  35. ncbi request reprint Impact of right ventricular involvement on mortality and morbidity in patients with inferior myocardial infarction
    S R Mehta
    Division of Cardiology, Hamilton Health Sciences Corporation, McMaster University, Ontario, Canada
    J Am Coll Cardiol 37:37-43. 2001
    ..We sought to evaluate the prognostic impact of right ventricular (RV) myocardial involvement in patients with inferior myocardial infarction (MI)...
  36. doi request reprint Dysglycaemia and the risk of acute myocardial infarction in multiple ethnic groups: an analysis of 15,780 patients from the INTERHEART study
    H C Gerstein
    The Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada
    Diabetologia 53:2509-17. 2010
    ..Although diabetes is an established risk factor for myocardial infarction (MI), disease control may vary. HbA(1c) is a reliable index of ambient glucose levels and may provide more information on MI risk than diabetes status...
  37. doi request reprint Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study
    MARTIN J O'DONNELL
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    Lancet 376:112-23. 2010
    ....
  38. doi request reprint Dabigatran versus warfarin in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 361:1139-51. 2009
    ..Warfarin reduces the risk of stroke in patients with atrial fibrillation but increases the risk of hemorrhage and is difficult to use. Dabigatran is a new oral direct thrombin inhibitor...
  39. ncbi request reprint Enalapril prevents clinical proteinuria in diabetic patients with low ejection fraction
    S E Capes
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 23:377-80. 2000
    ..The prevalence of clinical proteinuria, its correlates and predictive value, and the effect of ACE inhibitors in preventing clinical proteinuria in diabetic and nondiabetic patients with left ventricular (LV) dysfunction are unknown...
  40. ncbi request reprint Oral anticoagulant therapy in patients with coronary artery disease: a meta-analysis
    S S Anand
    Program of Preventive Cardiology and Therapeutics, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario, Canada
    JAMA 282:2058-67. 1999
    ..Despite years of use in coronary artery disease (CAD) and several studies of its effectiveness, the role of oral anticoagulants (OAs) remains controversial...
  41. ncbi request reprint Prognostic significance of thrombocytopenia during hirudin and heparin therapy in acute coronary syndrome without ST elevation: Organization to Assess Strategies for Ischemic Syndromes (OASIS-2)study
    J W Eikelboom
    Preventive Cardiology and Therapeutics Program, McMaster University, Hamilton, Canada
    Circulation 103:643-50. 2001
    ..The excess of major bleeding in hirudin-treated patients who develop thrombocytopenia suggests that thrombocytopenia may contribute to the increased risk of bleeding observed with hirudin...
  42. ncbi request reprint Safety outcomes in meta-analyses of phase 2 vs phase 3 randomized trials: Intracranial hemorrhage in trials of bolus thrombolytic therapy
    J W Eikelboom
    McMaster University, Hamilton General Hospital McMaster Clinic, 237 Barton St E, Hamilton, Ontario, Canada L8L 2X2
    JAMA 285:444-50. 2001
    ..Recent studies have reported disagreement between meta-analysis of small trials and subsequent large trials addressing the same question. However, disagreement for uncommon but serious adverse safety outcomes has not been examined...
  43. doi request reprint Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial
    Sanjit S Jolly
    McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    Lancet 377:1409-20. 2011
    ..We aimed to assess whether radial access was superior to femoral access in patients with acute coronary syndromes (ACS) who were undergoing coronary angiography with possible intervention...
  44. doi request reprint Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial
    Shamir R Mehta
    McMaster University and Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    Lancet 376:1233-43. 2010
    ..We assessed the effect of various clopidogrel and aspirin regimens in prevention of major cardiovascular events and stent thrombosis in patients undergoing PCI...
  45. ncbi request reprint Relationship of current and past smoking to mortality and morbidity in patients with left ventricular dysfunction
    N Suskin
    Division of Cardiology, London Health Science Center, Ontario, Canada
    J Am Coll Cardiol 37:1677-82. 2001
    ....
  46. ncbi request reprint Reliability, validity, and responsiveness of the six-minute walk test in patients with heart failure
    C Demers
    Preventive Cardiology and Therapeutics Research Program, Division of Cardiology, Hamilton Health Sciences Corporation-General Division and McMaster University, Hamilton, Ontario, Canada
    Am Heart J 142:698-703. 2001
    ..It is somewhat correlated to NYHA-FC and quality of life. Overall, quality of life was most responsive to change, whereas 6MWT and NYHA-FC were comparable but less responsive to change in the RESOLVD study...
  47. ncbi request reprint INTER-HEART: A global study of risk factors for acute myocardial infarction
    S Ounpuu
    Canadian Cardiovascular Collaboration, McMaster University, Canada
    Am Heart J 141:711-21. 2001
    ..This has ensured the feasibility of INTER-HEART. This study has the potential to have a major impact in developing a worldwide strategy for cardiovascular disease prevention, especially in developing countries and nonwhite populations...
  48. pmc Rationale, design and baseline characteristics of a large, simple, randomized trial of combined folic acid and vitamins B6 and B12 in high-risk patients: the Heart Outcomes Prevention Evaluation (HOPE)-2 trial
    E Lonn
    Hamilton Health Sciences Corporation, Hamilton, Ontario
    Can J Cardiol 22:47-53. 2006
    ..Therefore, a large, randomized clinical trial--the Heart Outcomes Prevention Evaluation (HOPE)-2 study--is being conducted to evaluate this therapy in patients at high risk for CV events...
  49. ncbi request reprint Low rates of preventive practices in patients with peripheral vascular disease
    S S Anand
    Hamilton Civic Hospitals Research Centre, McMaster University, Hamilton, Canada
    Can J Cardiol 15:1259-63. 1999
    ..Given the scarcity of data on the preventive practice patterns of this high risk patient group, the in-hospital management of patients admitted to hospital for a peripheral vascular intervention was reviewed...
  50. ncbi request reprint Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization
    S Yusuf
    Population Health Research Institute and Division of Cardiology, McMaster University, Hamilton, Ontario, Canada
    Circulation 104:2746-53. 2001
    ..Part II of this article describes the burden of CV disease by specific region or ethnic group, the risk factors of importance, and possible strategies for prevention...
  51. ncbi request reprint Ramipril and the development of diabetes
    S Yusuf
    Canadian Cardiovascular Collaboration Project Office, Hamilton General Hospital, 237 Barton St East, Hamilton, Ontario, Canada L8L 2X2
    JAMA 286:1882-5. 2001
    ..Type 2 diabetes is a growing clinical and public health problem. Preventive efforts related to lifestyle modification are not always successful; therefore, alternative prevention strategies need to be studied...
  52. ncbi request reprint Validity of the US Behavioral Risk Factor Surveillance System's health related quality of life survey tool in a group of older Canadians
    S Ounpuu
    Population Health Section, Hamilton General Hospital, McMaster Clinic and Department of Medicine, McMaster University, 237 Barton Street East, Hamilton, Ontario L8L 2X2
    Chronic Dis Can 22:93-101. 2001
    ..This study demonstrated that the HRQOL-4 is not only accepted by older adults in a self-administered format, but also stands up to tests of its validity...
  53. ncbi request reprint Impact of rosiglitazone on body composition, hepatic fat, fatty acids, adipokines and glucose in persons with impaired fasting glucose or impaired glucose tolerance: a sub-study of the DREAM trial
    Z Punthakee
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, ON, Canada Department of Medicine, McMaster University, Hamilton, ON, Canada
    Diabet Med 31:1086-92. 2014
    ..We aimed to measure these effects in people with impaired fasting glucose and/or impaired glucose tolerance...
  54. ncbi request reprint The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression
    Z Samaan
    1 Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada 2 Population Health Research Institute, Hamilton, ON, Canada
    Mol Psychiatry 18:1281-6. 2013
    ..This study highlights the potential importance of obesity predisposing genes on depression...
  55. doi request reprint Cardiovascular risk factors and non-invasive assessment of subclinical atherosclerosis in youth
    K M Morrison
    Mc Master University, HSC 3A59, 1200 Main Street W, Hamilton, ON, L8N 3Z5, Canada
    Atherosclerosis 208:501-5. 2010
    ..The age at which vascular changes can be reliably identified using IMT and the influence of CV risk factors beyond FH on IMT remains unclear...
  56. doi request reprint Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial
    P J Devereaux
    McMaster University, Faculty of Health Sciences, Clinical Epidemiology and Biostatistics, Room 2C8, 1200 Main Street West, Hamilton, ON, L8N 3Z5, Canada
    Lancet 371:1839-47. 2008
    ..This randomised controlled trial, done in 190 hospitals in 23 countries, was designed to investigate the effects of perioperative beta blockers...
  57. doi request reprint Salt intake and cardiovascular disease: why are the data inconsistent?
    M J O'Donnell
    Population Health Research Institute, DBCVS Research Institute, McMaster University, 3rd Floor, 237 Barton St East, Hamilton, Ont, Canada L8L 2X2
    Eur Heart J 34:1034-40. 2013
    ....
  58. doi request reprint Early versus delayed invasive intervention in acute coronary syndromes
    Shamir R Mehta
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 360:2165-75. 2009
    ..Earlier trials have shown that a routine invasive strategy improves outcomes in patients with acute coronary syndromes without ST-segment elevation. However, the optimal timing of such intervention remains uncertain...
  59. ncbi request reprint Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial
    S Connolly
    Health Research Institute, Hamilton, ON, Canada
    Lancet 367:1903-12. 2006
    ..However, long-term monitoring is necessary and many patients cannot achieve optimum anticoagulation. We assessed whether clopidogrel plus aspirin was non-inferior to oral anticoagulation therapy for prevention of vascular events...
  60. ncbi request reprint Global burden of cardiovascular diseases: Part II: variations in cardiovascular disease by specific ethnic groups and geographic regions and prevention strategies
    S Yusuf
    Population Health Research Institute and Division of Cardiology, McMaster University, Hamilton, Ontario, Canada
    Circulation 104:2855-64. 2001
    ..Part II of this article describes the burden of CV disease by specific region or ethnic group, the risk factors of importance, and possible strategies for prevention...
  61. ncbi request reprint The evolution of the randomized controlled trial and its role in evidence-based decision making
    P J Devereaux
    Department of Medicine and Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    J Intern Med 254:105-13. 2003
    ..We discuss the role of the randomized controlled trial within evidence-based decision making...
  62. ncbi request reprint Rationale and design of INTERSTROKE: a global case-control study of risk factors for stroke
    M O'DONNELL
    Population Health Research Group, McMaster University, Hamilton, ON L8L 2X2, Canada
    Neuroepidemiology 35:36-44. 2010
    ..Accordingly, a similar epidemiological study is required for stroke, to inform effective population-based strategies to reduce the risk of stroke...
  63. ncbi request reprint Rationale, design and recruitment characteristics of a large, simple international trial of diabetes prevention: the DREAM trial
    H C Gerstein
    Population Health Research Institute, Hamilton, Ontario, Canada
    Diabetologia 47:1519-27. 2004
    ..This risk can be reduced by lifestyle changes and/or various drugs. Novel therapies to prevent diabetes, as well as new risk factors for diabetes, atherosclerosis and obesity require testing and identification...
  64. pmc Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample
    Matthew B Lanktree
    Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    J Lipid Res 50:1487-96. 2009
    ..The findings indicate the potential utility of the Illumina CVD beadchip, but they underscore the need to consider meta-analysis of results from commonly studied clinical or epidemiological samples...
  65. ncbi request reprint Previous exposure to Chlamydia pneumoniae, Helicobacter pylori and other infections in Canadian patients with ischemic heart disease
    M Smieja
    St Joseph's Hospital, Hamilton, Canada
    Can J Cardiol 17:270-6. 2001
    ..A prospective validation of this association is needed...
  66. ncbi request reprint Effects of physiologic pacing versus ventricular pacing on the risk of stroke and death due to cardiovascular causes. Canadian Trial of Physiologic Pacing Investigators
    S J Connolly
    Department of Medicine, McMaster University, Hamilton, Ont, Canada
    N Engl J Med 342:1385-91. 2000
    ..These benefits have not been evaluated in a large, randomized, controlled trial...
  67. pmc Risk of hospitalization during influenza season among a cohort of patients with congestive heart failure
    C Sandoval
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Epidemiol Infect 135:574-82. 2007
    ..98-1.24, P=0.11). Patients with CHF have a greater risk of hospitalization during the influenza season than in the non-influenza season, supporting the current belief that patients with CHF should be regarded as a high-risk group...
  68. ncbi request reprint Recurrent events in meta-analysis of multiple clinical trials
    Y Wang
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada Robertson
    Zhongguo Yao Li Xue Bao 20:495-9. 1999
    ..To study the efficacy and safety of drug or therapy with recurrent events in meta-analysis of multiple clinical trials...
  69. ncbi request reprint Efficacy of hirudin in reducing cardiovascular events in patients with acute coronary syndrome undergoing early percutaneous coronary intervention
    S R Mehta
    Division of Cardiology, Hamilton Health Sciences Corporation, McMaster University Medical Center, 1200 Main Street West, HSC 3U5, Hamilton, Ontario, Canada L8N 3Z5
    Eur Heart J 23:117-23. 2002
    ....
  70. ncbi request reprint Is there a role for antioxidant vitamins in the prevention of cardiovascular diseases? An update on epidemiological and clinical trials data
    E M Lonn
    Division of Cardiology, McMaster University, Hamilton, Ontario
    Can J Cardiol 13:957-65. 1997
    ..To review prospective epidemiological studies and randomized clinical trials regarding the role of antioxidant vitamins (vitamins E and C and beta-carotene) in the prevention of cardiovascular diseases...
  71. ncbi request reprint The 2002/3 Canadian Cardiovascular Society consensus guideline update for the diagnosis and management of heart failure
    P Liu
    Heart and Stroke RL Centre of Excellence, Toronto General Hospital, Ontario, Canada
    Can J Cardiol 19:347-56. 2003
  72. ncbi request reprint Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial
    Christopher B Granger
    Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    Lancet 362:772-6. 2003
    ..We aimed to find out whether candesartan, an angiotensin-receptor blocker, could improve outcome in such patients not taking an ACE inhibitor...
  73. ncbi request reprint Risks and benefits of oral anticoagulation compared with clopidogrel plus aspirin in patients with atrial fibrillation according to stroke risk: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events (ACTIVE-W)
    Jeff S Healey
    Population Health Research Institute, McMaster University, 237 Barton St E, Hamilton, Ontario, Canada
    Stroke 39:1482-6. 2008
    ..However, because OAC carries important bleeding complications, risk stratification schemes have been devised to identify patients for whom the absolute benefits of OAC exceed its risks...
  74. doi request reprint The role of fondaparinux as an adjunct to thrombolytic therapy in acute myocardial infarction: a subgroup analysis of the OASIS-6 trial
    Ron J G Peters
    Department of Cardiology, Academic Medical Center, Room F3 236, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    Eur Heart J 29:324-31. 2008
    ..In the OASIS-6 trial, fondaparinux significantly reduced mortality and reinfarction without increasing bleeding in 12 092 patients with acute ST elevation MI...
  75. ncbi request reprint Interrelation of saturated fat, trans fat, alcohol intake, and subclinical atherosclerosis
    Anwar T Merchant
    Population Health Research Institute, Hamilton, Ontario, Canada
    Am J Clin Nutr 87:168-74. 2008
    ..Intake of saturated fat, trans fat, and alcohol alter cardiovascular disease risk, but their effect on subclinical atherosclerosis remains understudied...
  76. pmc Risk factors, hospital management and outcomes after acute myocardial infarction in South Asian Canadians and matched control subjects
    Milan Gupta
    William Osler Health Centre, Brampton, Ont
    CMAJ 166:717-22. 2002
    ..We compared differences in presentation, risk factors and management of myocardial infarction (MI) between South Asian Canadians and matched control subjects...
  77. ncbi request reprint Effects of fondaparinux in patients with ST-segment elevation acute myocardial infarction not receiving reperfusion treatment
    Jonas Oldgren
    Uppsala Clinical Research Center, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Eur Heart J 29:315-23. 2008
    ..We evaluated fondaparinux treatment vs. usual care, i.e. placebo or unfractionated (UF) heparin, in a pre-specified subgroup of 2867 (out of 12 092) patients not receiving reperfusion treatment in the OASIS-6 trial...
  78. ncbi request reprint Effects of aspirin dose when used alone or in combination with clopidogrel in patients with acute coronary syndromes: observations from the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) study
    Ron J G Peters
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Circulation 108:1682-7. 2003
    ..We studied the benefits and risks of adding clopidogrel to different doses of aspirin in the treatment of patients with acute coronary syndrome (ACS)...
  79. ncbi request reprint Glucose-insulin-potassium therapy in patients with ST-segment elevation myocardial infarction
    Rafael Diaz
    Etudios Cardiologica Latin America, Rosario, Argentina
    JAMA 298:2399-405. 2007
    ..While some smaller trials suggest benefit, in the CREATE-ECLA trial, GIK infusion had no effect on 30-day mortality in 20,201 patients...
  80. ncbi request reprint Infarct size, ejection fraction, and mortality in diabetic patients with acute myocardial infarction treated with thrombolytic therapy
    Jorge R Alegria
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Am Heart J 154:743-50. 2007
    ..The purpose of this study was to examine if larger infarct size explains the higher mortality in diabetic patients with acute ST-segment-elevation MI...
  81. ncbi request reprint The Editor's Roundtable: arterial thrombosis and acute coronary syndromes
    Vincent E Friedewald
    Department of Internal Medicine, The University of Texas Medical School at Houston, Houston, Texas, USA
    Am J Cardiol 100:974-80. 2007
  82. ncbi request reprint Rationale, design, and baseline characteristics for a large international trial of cardiovascular disease prevention in people with dysglycemia: the ORIGIN Trial (Outcome Reduction with an Initial Glargine Intervention)
    Hertzel Gerstein
    Am Heart J 155:26-32, 32.e1-6. 2008
    ..Thus, targeting normal fasting glucose levels with insulin may reduce CV events. Previous studies suggest that omega-3 fatty acid supplements may reduce CV death; however, their effect in high-risk dysglycemic individuals is not known...
  83. ncbi request reprint Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial
    Johannes F E Mann
    Schwabing General Hospital, and KfH Kidney Centre, Ludwig Maximilians University Munchen, Germany
    Lancet 372:547-53. 2008
    ..We investigated the renal effects of ramipril (an ACE inhibitor), telmisartan (an ARB), and their combination in patients aged 55 years or older with established atherosclerotic vascular disease or with diabetes with end-organ damage...
  84. ncbi request reprint Benefit of clopidogrel in patients with acute coronary syndromes without ST-segment elevation in various risk groups
    Andrzej Budaj
    Postgraduate Medical School, Grochowski Hospital Warsaw, Poland
    Circulation 106:1622-6. 2002
    ..The purpose of the present analysis was to estimate the treatment effect Zof clopidogrel in patients who were stratified according to their risk of future cardiovascular events...
  85. ncbi request reprint Relationship of anti-60 kDa heat shock protein and anti-cholesterol antibodies to cardiovascular events
    Amarilla Veres
    Third Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Circulation 106:2775-80. 2002
    ..We evaluated whether high levels of antibodies against heat shock proteins and cholesterol (ACHA) predicted cardiovascular (CV) events...
  86. ncbi request reprint Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events
    John W Eikelboom
    Department of Medicine, University of Western Australia, Thrombosis and Haemophilia Unit, Royal Perth Hospital, Perth, Australia
    Circulation 105:1650-5. 2002
    ..We studied whether aspirin resistance, defined as failure of suppression of thromboxane generation, increases the risk of cardiovascular events in a high-risk population...
  87. ncbi request reprint The relevance of subgroup-specific treatment effects: the Studies Of Left Ventricular Dysfunction (SOLVD) revisited
    Andrea B Parker
    Institute of Medical Sciences, University of Toronto, and Cardiac Research Inc, Toronto, Ontario, Canada
    Am Heart J 144:941-7. 2002
    ..We reanalyzed the Studies of Left Ventricular Dysfunction (SOLVD) to determine whether the treatment effect depended on the patients' baseline prognosis, defined on the basis of multiple clinical variables...
  88. ncbi request reprint Influence of ejection fraction on cardiovascular outcomes in a broad spectrum of heart failure patients
    Scott D Solomon
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02445, USA
    Circulation 112:3738-44. 2005
    ..The growing number of patients with preserved systolic function heart failure underscores the importance of understanding the relationship between ejection fraction and risk...
  89. ncbi request reprint Relationship of metabolic syndrome and fibrinolytic dysfunction to cardiovascular disease
    Sonia S Anand
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Circulation 108:420-5. 2003
    ..Individuals with this syndrome suffer an excess of cardiovascular disease (CVD) for reasons that are unclear...
  90. ncbi request reprint Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme
    Marc A Pfeffer
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Lancet 362:759-66. 2003
    ..Patients with chronic heart failure (CHF) are at high risk of cardiovascular death and recurrent hospital admissions. We aimed to find out whether the use of an angiotensin-receptor blocker could reduce mortality and morbidity...
  91. ncbi request reprint Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial
    John J V McMurray
    University of Glasgow, Glasgow, UK
    Lancet 362:767-71. 2003
    ..We aimed to find out whether these drugs improve clinical outcome...
  92. pmc Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke
    Ralph L Sacco
    Miller School of Medicine, University of Miami, Miami, USA
    N Engl J Med 359:1238-51. 2008
    ..Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens--aspirin plus extended-release dipyridamole (ASA-ERDP) versus clopidogrel...
  93. ncbi request reprint Influence of renal function on the efficacy and safety of fondaparinux relative to enoxaparin in non ST-segment elevation acute coronary syndromes
    Keith A A Fox
    Cardiovascular Research, University of Edinburgh, Edinburgh, United Kingdom
    Ann Intern Med 147:304-10. 2007
    ..Renal dysfunction increases the risk for major bleeding...
  94. ncbi request reprint Body mass index and prognosis in patients with chronic heart failure: insights from the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) program
    Satish Kenchaiah
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 116:627-36. 2007
    ..However, in patients with certain specific chronic diseases, including heart failure, low BMI has been associated with increased mortality...
  95. ncbi request reprint Increased occurrence of diabetes in people with ischemic cardiovascular disease and general and abdominal obesity
    Gilles R Dagenais
    Laval University Heart and Lung Institute, Ste Foy, Quebec, Canada
    Can J Cardiol 19:1387-91. 2003
    ..Such a relationship has not been assessed in patients with ICVD who may have a different occurrence due to their disease and medications...
  96. ncbi request reprint Long-term cost-effectiveness of early and sustained clopidogrel therapy for up to 1 year in patients undergoing percutaneous coronary intervention after presenting with acute coronary syndromes without ST-segment elevation
    Elizabeth M Mahoney
    New England Research Institutes, Watertown, MA 02472, USA
    Am Heart J 151:219-27. 2006
    ..We evaluated the long-term cost-effectiveness of clopidogrel use for up to 1 year using patient-level outcomes and resource use from PCI-CURE, and estimates of life expectancy gains based on external sources...
  97. ncbi request reprint Unfractionated and low-molecular-weight heparin as adjuncts to thrombolysis in aspirin-treated patients with ST-elevation acute myocardial infarction: a meta-analysis of the randomized trials
    John W Eikelboom
    General Division, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Circulation 112:3855-67. 2005
    ..There is uncertainty about the role of intravenous unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH) in patients with ST-elevation myocardial infarction (STEMI) treated with aspirin and thrombolysis...
  98. ncbi request reprint Adherence to candesartan and placebo and outcomes in chronic heart failure in the CHARM programme: double-blind, randomised, controlled clinical trial
    Bradi B Granger
    Duke University Medical Center and Duke University School of Nursing, Durham, NC, USA
    Lancet 366:2005-11. 2005
    ....
  99. ncbi request reprint Benefit of clopidogrel according to timing of percutaneous coronary intervention in patients with acute coronary syndromes: further results from the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) study
    Basil S Lewis
    Lady Davis Carmel Medical Center, Haifa, Israel
    Am Heart J 150:1177-84. 2005
    ..In the present study, we examined the relation between clopidogrel therapy, timing of PCI, and cardiovascular (CV) events in patients participating in the CURE study...
  100. ncbi request reprint Design and rationale of the MICHELANGELO Organization to Assess Strategies in Acute Ischemic Syndromes (OASIS)-5 trial program evaluating fondaparinux, a synthetic factor Xa inhibitor, in patients with non-ST-segment elevation acute coronary syndromes
    Shamir R Mehta
    Am Heart J 150:1107. 2005
    ..We designed a large, phase III, randomized trial to evaluate the efficacy and safety of fondaparinux compared with enoxaparin in acute coronary syndromes...
  101. ncbi request reprint Impact of candesartan on nonfatal myocardial infarction and cardiovascular death in patients with heart failure
    Catherine Demers
    McMaster University, Hamilton, Ontario, Canada
    JAMA 294:1794-8. 2005
    ..Angiotensin-converting enzyme (ACE) inhibitors reduce the risk of myocardial infarction (MI), but it is not known whether angiotensin receptor blockers have the same effect...