S Yusuf

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization
    S Yusuf
    Population Health Research Institute and Division of Cardiology, McMaster University, Hamilton, Ontario, Canada
    Circulation 104:2746-53. 2001
  2. pmc Differences in perceptions and fast food eating behaviours between Indians living in high- and low-income neighbourhoods of Chandigarh, India
    Christopher Robert Aloia
    Simon Fraser University, Burnaby, BC, Canada
    Nutr J 12:4. 2013
  3. pmc BRCA2 variants and cardiovascular disease in a multi-ethnic study
    Kevin Zbuk
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    BMC Med Genet 13:56. 2012
  4. doi request reprint Comparison of risk factor reduction and tolerability of a full-dose polypill (with potassium) versus low-dose polypill (polycap) in individuals at high risk of cardiovascular diseases: the Second Indian Polycap Study (TIPS-2) investigators
    Salim Yusuf
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, Canada
    Circ Cardiovasc Qual Outcomes 5:463-71. 2012
  5. pmc Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample
    Salam A Al-Attar
    Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Diabetol 7:5. 2008
  6. pmc Testing for heterogeneity among the components of a binary composite outcome in a clinical trial
    Janice Pogue
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    BMC Med Res Methodol 10:49. 2010
  7. pmc Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample
    Rebecca L Pollex
    Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada
    BMC Med Genet 8:80. 2007
  8. doi request reprint Deciphering the causes of cardiovascular and other complex diseases in populations: achievements, challenges, opportunities, and approaches
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
    Prog Cardiovasc Dis 53:62-7. 2010
  9. ncbi request reprint Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada
    Lancet 366:1640-9. 2005
  10. ncbi request reprint Early and late effects of clopidogrel in patients with acute coronary syndromes
    Salim Yusuf
    Population Health Research Institute and Division of Cardiology, McMaster University, Hamilton, Canada
    Circulation 107:966-72. 2003

Collaborators

Detail Information

Publications166 found, 100 shown here

  1. ncbi request reprint Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization
    S Yusuf
    Population Health Research Institute and Division of Cardiology, McMaster University, Hamilton, Ontario, Canada
    Circulation 104:2746-53. 2001
    ..Part II of this article describes the burden of CV disease by specific region or ethnic group, the risk factors of importance, and possible strategies for prevention...
  2. pmc Differences in perceptions and fast food eating behaviours between Indians living in high- and low-income neighbourhoods of Chandigarh, India
    Christopher Robert Aloia
    Simon Fraser University, Burnaby, BC, Canada
    Nutr J 12:4. 2013
    ..The purpose of the study is to explore the differences in fast food preferences, perceptions, and patronage between Indians living in high- and low-income neighbourhoods...
  3. pmc BRCA2 variants and cardiovascular disease in a multi-ethnic study
    Kevin Zbuk
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    BMC Med Genet 13:56. 2012
    ..We therefore tested the association of BRCA2 variants with clinical cardiovascular disease (CVD)...
  4. doi request reprint Comparison of risk factor reduction and tolerability of a full-dose polypill (with potassium) versus low-dose polypill (polycap) in individuals at high risk of cardiovascular diseases: the Second Indian Polycap Study (TIPS-2) investigators
    Salim Yusuf
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, Canada
    Circ Cardiovasc Qual Outcomes 5:463-71. 2012
    ..We examined the incremental effects of 2 (full dose) plus K(+) supplementation versus single polycap (low dose) on risk factors and tolerability...
  5. pmc Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample
    Salam A Al-Attar
    Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Diabetol 7:5. 2008
    ..The objective of this study is to examine whether this association extends to metabolic syndrome (MetS) and applies in non-Caucasian samples...
  6. pmc Testing for heterogeneity among the components of a binary composite outcome in a clinical trial
    Janice Pogue
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    BMC Med Res Methodol 10:49. 2010
    ..This paper compares the power of different tests to detect heterogeneity of treatment effect across components of a composite binary outcome...
  7. pmc Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample
    Rebecca L Pollex
    Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada
    BMC Med Genet 8:80. 2007
    ..The objective of this study is to examine the APOC3 -455T>C and the INSIG2 rs7566605 polymorphisms as potential genetic determinants for MetS in a multi-ethnic sample...
  8. doi request reprint Deciphering the causes of cardiovascular and other complex diseases in populations: achievements, challenges, opportunities, and approaches
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
    Prog Cardiovasc Dis 53:62-7. 2010
    ....
  9. ncbi request reprint Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada
    Lancet 366:1640-9. 2005
    ..We aimed to assess whether markers of obesity, especially waist-to-hip ratio, would be stronger indicators of myocardial infarction than body-mass index (BMI), the conventional measure...
  10. ncbi request reprint Early and late effects of clopidogrel in patients with acute coronary syndromes
    Salim Yusuf
    Population Health Research Institute and Division of Cardiology, McMaster University, Hamilton, Canada
    Circulation 107:966-72. 2003
    ..We examine the benefits and risks associated with the use of adding clopidogrel to aspirin within the first 30 days and later (31 days to 12 months) in 12 562 patients with ACS...
  11. ncbi request reprint Effects of candesartan on the development of a new diagnosis of diabetes mellitus in patients with heart failure
    Salim Yusuf
    Population Health Research Institute, McMaster University, and Hamilton Health Sciences, Hamilton, Canada
    Circulation 112:48-53. 2005
    ....
  12. ncbi request reprint Challenges in the conduct of large simple trials of important generic questions in resource-poor settings: the CREATE and ECLA trial program evaluating GIK (glucose, insulin and potassium) and low-molecular-weight heparin in acute myocardial infarction
    Salim Yusuf
    Department of Medicine, McMaster University, and Population Health Research Institute, Hamilton General Hospital, Hamilton, Canada
    Am Heart J 148:1068-78. 2004
    ..Although glucose-insulin-potassium (GIK) infusion and low-molecular-weight heparin (LMWH) appear to be promising in AMI, the available trials are inconclusive and these treatments require rigorous evaluation...
  13. ncbi request reprint Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial
    Salim Yusuf
    McMaster Clinic, Room 252, Hamilton General Hospital, 237 Barton Street East, ON, L8L 2X2, Hamilton, Canada
    Lancet 362:777-81. 2003
    ..We investigated the effect of addition of an angiotensin-receptor blocker to current treatments...
  14. ncbi request reprint Ramipril and the development of diabetes
    S Yusuf
    Canadian Cardiovascular Collaboration Project Office, Hamilton General Hospital, 237 Barton St East, Hamilton, Ontario, Canada L8L 2X2
    JAMA 286:1882-5. 2001
    ..Type 2 diabetes is a growing clinical and public health problem. Preventive efforts related to lifestyle modification are not always successful; therefore, alternative prevention strategies need to be studied...
  15. ncbi request reprint Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study
    Salim Yusuf
    Population Health Research Institute, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2
    Lancet 364:937-52. 2004
    ..Therefore, the effect of such factors on risk of coronary heart disease in most regions of the world is unknown...
  16. ncbi request reprint From the HOPE to the ONTARGET and the TRANSCEND studies: challenges in improving prognosis
    Salim Yusuf
    Division of Cardiology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Cardiol 89:18A-25A; discussion 25A-26A. 2002
    ..These 2 trials are expected to provide new insights into the optimal treatment of patients at high risk of complications from atherosclerosis...
  17. pmc Hormone replacement therapy: a time for pause
    Salim Yusuf
    Heart and Stroke Foundation of Ontario, Canadian Institutues of Health Research, McMaster University, Hamilton
    CMAJ 167:357-9. 2002
  18. ncbi request reprint Two decades of progress in preventing vascular disease
    Salim Yusuf
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada L8L 2X2
    Lancet 360:2-3. 2002
  19. doi request reprint Telmisartan, ramipril, or both in patients at high risk for vascular events
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 358:1547-59. 2008
    ..We compared the ACE inhibitor ramipril, the ARB telmisartan, and the combination of the two drugs in patients with vascular disease or high-risk diabetes...
  20. ncbi request reprint Independent design and conduct of clinical trials
    Salim Yusuf
    Department of Medicine, Division of Cardiology, McMaster University, Hamilton, Ontario, Canada, Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Clin Trials 3:503-7. 2006
    ..The most frequent type of RCT are those evaluating therapies, and much of this commentary will be focused on issues relevant to such trials, although the principles apply generally...
  21. doi request reprint Use of secondary prevention drugs for cardiovascular disease in the community in high-income, middle-income, and low-income countries (the PURE Study): a prospective epidemiological survey
    Salim Yusuf
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada
    Lancet 378:1231-43. 2011
    ....
  22. ncbi request reprint Effects of fondaparinux on mortality and reinfarction in patients with acute ST-segment elevation myocardial infarction: the OASIS-6 randomized trial
    Salim Yusuf
    Department of Medicine, McMaster University and Hamilton Health Sciences, McMaster Clinic, Hamilton General Hospital, Hamilton, Ontario, Canada
    JAMA 295:1519-30. 2006
    ..The role of additional antithrombotic agents is unclear, especially among patients not receiving reperfusion therapy...
  23. ncbi request reprint The Study of Health Assessment and Risk in Ethnic groups (SHARE): rationale and design. The SHARE Investigators
    S S Anand
    Preventive Cardiology and Therapeutics Research Program, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario
    Can J Cardiol 14:1349-57. 1998
    ..The relationship between the conventional and emerging risk factors, and atherosclerosis, vascular disease and markers of end-organ damage will be evaluated between and within ethnic groups...
  24. ncbi request reprint Prevalence and determinants of microalbuminuria in high-risk diabetic and nondiabetic patients in the Heart Outcomes Prevention Evaluation Study. The HOPE Study Investigators
    H C Gerstein
    McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 23:B35-9. 2000
    ....
  25. ncbi request reprint Differences in risk factors, atherosclerosis, and cardiovascular disease between ethnic groups in Canada: the Study of Health Assessment and Risk in Ethnic groups (SHARE)
    S S Anand
    Department of Medicine, McMaster University, Ontario, Canada
    Lancet 356:279-84. 2000
    ..To establish whether this variation can be explained by differences in disease risk factors and subclinical atherosclerosis, we undertook a population-based study of three ethnic groups in Canada: South Asians, Chinese, and Europeans...
  26. ncbi request reprint Long-term oral anticoagulant therapy in patients with unstable angina or suspected non-Q-wave myocardial infarction: organization to assess strategies for ischemic syndromes (OASIS) pilot study results
    S S Anand
    From the Preventive Cardiology and Therapeutics Program, Hamilton Civics Hospital Research Centre, and Division of Cardiology, McMaster University, Hamilton, Canada
    Circulation 98:1064-70. 1998
    ..We studied the effects of long-term warfarin at 2 intensities in patients with AIS without ST elevation in 2 consecutive randomized controlled studies...
  27. doi request reprint Glucose levels are associated with cardiovascular disease and death in an international cohort of normal glycaemic and dysglycaemic men and women: the EpiDREAM cohort study
    S S Anand
    Population Health Research Institute, Hamilton, Ontario, Canada
    Eur J Prev Cardiol 19:755-64. 2012
    ..In an international prospective cohort study we assessed the relationship between glucose levels and incident cardiovascular events and death...
  28. ncbi request reprint Variations between countries in invasive cardiac procedures and outcomes in patients with suspected unstable angina or myocardial infarction without initial ST elevation. OASIS (Organisation to Assess Strategies for Ischaemic Syndromes) Registry Investiga
    S Yusuf
    McMaster University, Hamilton, Ontario, Canada
    Lancet 352:507-14. 1998
    ....
  29. doi request reprint Design and rationale of CURRENT-OASIS 7: a randomized, 2 x 2 factorial trial evaluating optimal dosing strategies for clopidogrel and aspirin in patients with ST and non-ST-elevation acute coronary syndromes managed with an early invasive strategy
    Shamir R Mehta
    McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Am Heart J 156:1080-1088.e1. 2008
    ....
  30. ncbi request reprint Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study
    S R Mehta
    Division of Cardiology, the Population Health Research Institute and the Canadian Cardiovascular Collaboration Project Office, McMaster University, Hamilton, Canada
    Lancet 358:527-33. 2001
    ..We aimed to find out whether, in addition to aspirin, pretreatment with clopidogrel followed by long-term therapy after PCI is superior to a strategy of no pretreatment and short-term therapy for only 4 weeks after PCI...
  31. doi request reprint The Prospective Urban Rural Epidemiology (PURE) study: examining the impact of societal influences on chronic noncommunicable diseases in low-, middle-, and high-income countries
    Koon Teo
    Population Health Research Institute, McMaster University Hamilton Health Sciences, Hamilton, Ontario, Canada
    Am Heart J 158:1-7.e1. 2009
    ..The overarching aim of the study is to examine the relationship of societal influences on human lifestyle behaviors, cardiovascular risk factors, and incidence of chronic noncommunicable diseases...
  32. doi request reprint Irbesartan in patients with atrial fibrillation
    Salim Yusuf
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    N Engl J Med 364:928-38. 2011
    ..The risk of cardiovascular events among patients with atrial fibrillation is high. We evaluated whether irbesartan, an angiotensin-receptor blocker, would reduce this risk...
  33. doi request reprint Effects of telmisartan, ramipril, and their combination on left ventricular hypertrophy in individuals at high vascular risk in the Ongoing Telmisartan Alone and in Combination With Ramipril Global End Point Trial and the Telmisartan Randomized Assessment
    Paolo Verdecchia
    McMaster University, Population Health Research Institute, 237 Barton St E, Hamilton, ON L8L2X2 Canada
    Circulation 120:1380-9. 2009
    ..Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers reduce left ventricular hypertrophy (LVH). The effect of these drugs on LVH in high-risk patients without heart failure is unknown...
  34. ncbi request reprint Relationship of metabolic syndrome and fibrinolytic dysfunction to cardiovascular disease
    Sonia S Anand
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Circulation 108:420-5. 2003
    ..Individuals with this syndrome suffer an excess of cardiovascular disease (CVD) for reasons that are unclear...
  35. ncbi request reprint Rationale and design of ACTIVE: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events
    S Connolly
    Population Health Research Institute, Hamilton, Ontario, Canada
    Am Heart J 151:1187-93. 2006
    ..Irbesartan is an angiotensin receptor-blocking agent that reduces blood pressure and has other vascular protective effects...
  36. ncbi request reprint Effects of ramipril and vitamin E on atherosclerosis: the study to evaluate carotid ultrasound changes in patients treated with ramipril and vitamin E (SECURE)
    E Lonn
    Departments of Medicine, McMaster University, Hamilton, Ontario, Canada
    Circulation 103:919-25. 2001
    ....
  37. ncbi request reprint Stroke in relation to cardiac procedures in patients with non-ST-elevation acute coronary syndrome: a study involving >18 000 patients
    L Cronin
    Preventive Cardiology and Therapeutics Program and the Division of Cardiology, McMaster University, Hamilton, Canada
    Circulation 104:269-74. 2001
    ..95; P=0.0001). CONCLUSIONS: In this large cohort of patients with ACS, stroke was an uncommon but serious event associated with high mortality. The performance of early CABG surgery was a powerful independent predictor of stroke...
  38. ncbi request reprint Comparison of candesartan, enalapril, and their combination in congestive heart failure: randomized evaluation of strategies for left ventricular dysfunction (RESOLVD) pilot study. The RESOLVD Pilot Study Investigators
    R S McKelvie
    Hamilton Health Sciences Corporation General Division, and McMaster University, Hamilton, Ontario, Canada
    Circulation 100:1056-64. 1999
    ....
  39. ncbi request reprint The HOPE (Heart Outcomes Prevention Evaluation) Study and its consequences
    M J McQueen
    Hamilton Regional Laboratory Medicine Program, Department of Laboratory Medicine, St Joseph s Hospital, Hamilton, Ontario
    Scand J Clin Lab Invest Suppl 240:143-56. 2005
    ..Sub-studies completed and on-going into the predictive role of natriuretic peptides, infectious and inflammatory markers, provide insight into possible mechanisms of action of Ramipril...
  40. ncbi request reprint Rationale and design of a large study to evaluate the renal and cardiovascular effects of an ACE inhibitor and vitamin E in high-risk patients with diabetes. The MICRO-HOPE Study. Microalbuminuria, cardiovascular, and renal outcomes. Heart Outcomes Preven
    H C Gerstein
    McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 19:1225-8. 1996
    ....
  41. ncbi request reprint Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
    S Yusuf
    Canadian Cardiovascular Collaboration Project Office, Hamilton General Hospital, ON
    N Engl J Med 342:154-60. 2000
    ..Observational and experimental studies suggest that the amount of vitamin E ingested in food and in supplements is associated with a lower risk of coronary heart disease and atherosclerosis...
  42. ncbi request reprint Risk factors, atherosclerosis, and cardiovascular disease among Aboriginal people in Canada: the Study of Health Assessment and Risk Evaluation in Aboriginal Peoples (SHARE-AP)
    S S Anand
    Preventive Cardiology and Therapeutics Research Program, Department of Medicine, McMaster University, Ontario, L8L 2X2, Hamilton, Canada
    Lancet 358:1147-53. 2001
    ..To establish the relative prevalence of risk factors, atherosclerosis, and CVD, we undertook a population-based study among people of Aboriginal and European ancestry in Canada...
  43. ncbi request reprint Defining obesity cut points in a multiethnic population
    Fahad Razak
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    Circulation 115:2111-8. 2007
    ..It is unknown whether these cut points are appropriate for non-European populations. We assessed the metabolic risk associated with BMI among South Asians, Chinese, Aboriginals, and Europeans...
  44. doi request reprint Apixaban in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 364:806-17. 2011
    ..Apixaban, a novel factor Xa inhibitor, may be an alternative treatment for such patients...
  45. doi request reprint Increased cardiovascular risk after pre-eclampsia in women with dysglycaemia
    S D McDonald
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada
    Diabet Med 30:e1-7. 2013
    ..Our objective was to determine if the high risk of cardiovascular disease in women with pre-eclampsia is accounted for by known cardiovascular risk factors including albuminuria...
  46. ncbi request reprint Reduction of cardiovascular risk by regression of electrocardiographic markers of left ventricular hypertrophy by the angiotensin-converting enzyme inhibitor ramipril
    J Mathew
    Division of Cardiology, Department of Medicine, University of Iowa College of Medicine, Iowa City, and Galesburg Cottage Hospital, Galesburg, Illinois, USA
    Circulation 104:1615-21. 2001
    ..We determined whether the ACE inhibitor ramipril prevents the development and causes regression of ECG-LVH and whether these changes are associated with improved prognosis independent of blood pressure reduction...
  47. ncbi request reprint Venous thromboembolism in association with features of the metabolic syndrome
    J G Ray
    Department of Medicine, St Michael s Hospital, University of Toronto, Ontario M5B 1W8, Canada
    QJM 100:679-84. 2007
    ..However, whether each of these factors additively increases the risk of VTE is uncertain...
  48. ncbi request reprint Relationship of glucose and insulin levels to the risk of myocardial infarction: a case-control study
    H C Gerstein
    Preventive Cardiology and Therapeutics Research Program, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario, Canada
    J Am Coll Cardiol 33:612-9. 1999
    ..To assess the relationship between dysglycemia and myocardial infarction in nondiabetic individuals...
  49. ncbi request reprint Two-year outcomes in patients admitted with non-ST elevation acute coronary syndrome: results of the OASIS registry 1 and 2
    Dorairaj Prabhakaran
    McMaster University, Hamilton, Canada
    Indian Heart J 57:217-25. 2005
    ..This study sought to compare baseline characteristics, practice patterns and clinical outcomes for patients with non-ST elevation acute coronary syndrome from a broad range of low-, middle- and high-income countries...
  50. pmc Telmisartan to prevent recurrent stroke and cardiovascular events
    Salim Yusuf
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    N Engl J Med 359:1225-37. 2008
    ..We evaluated the effects of therapy with an angiotensin-receptor blocker, telmisartan, initiated early after a stroke...
  51. doi request reprint Comparison of the anticoagulant intensities of fondaparinux and enoxaparin in the Organization to Assess Strategies in Acute Ischemic Syndromes (OASIS)-5 trial
    J A M Anderson
    Division of Hematology, and Cardiology, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    J Thromb Haemost 8:243-9. 2010
    ..The mechanism of lower bleeding and improved efficacy with fondaparinux is uncertain...
  52. doi request reprint Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study
    MARTIN J O'DONNELL
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    Lancet 376:112-23. 2010
    ....
  53. ncbi request reprint Ethnic differences in the relationships between obesity and glucose-metabolic abnormalities: a cross-sectional population-based study
    F Razak
    Population Health Research Institute, McMaster University, Hamilton General Hospital, Hamilton, ON, Canada
    Int J Obes (Lond) 29:656-67. 2005
    ..To evaluate whether body mass index (BMI) and other anthropometric indices of visceral obesity vary by ethnic group in their distribution and their relationship to metabolic abnormalities...
  54. doi request reprint Risks and benefits of oral anticoagulation compared with clopidogrel plus aspirin in patients with atrial fibrillation according to stroke risk: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events (ACTIVE-W)
    Jeff S Healey
    Population Health Research Institute, McMaster University, 237 Barton St E, Hamilton, Ontario, Canada
    Stroke 39:1482-6. 2008
    ..However, because OAC carries important bleeding complications, risk stratification schemes have been devised to identify patients for whom the absolute benefits of OAC exceed its risks...
  55. ncbi request reprint Comparative impact of enalapril, candesartan or metoprolol alone or in combination on ventricular remodelling in patients with congestive heart failure
    Robert S McKelvie
    Hamilton Health Sciences, General Division, Ontario, Hamilton, Canada
    Eur Heart J 24:1727-34. 2003
    ..Patients were later randomized to metoprolol CR (M) or placebo. Examine impact of C or E (C/E), C+E, C+M/E+M, C+E+M on ventricular remodelling in heart failure (HF) over 43 weeks...
  56. doi request reprint Design, history and results of the Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) randomised controlled trial
    Z Punthakee
    Population Health Research Institute, McMaster University, 237 Barton St E, Hamilton, ON, Canada, L8L 2X2
    Diabetologia 55:36-45. 2012
    ....
  57. ncbi request reprint Anthropometric measures and glucose levels in a large multi-ethnic cohort of individuals at risk of developing type 2 diabetes
    L de Koning
    The Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    Diabetologia 53:1322-30. 2010
    ..We also explored variation in anthropometric associations by sex and ethnicity...
  58. ncbi request reprint Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals
    H C Gerstein
    Department of Medicine, Room 3V38, 1200 Main St W, Hamilton, Ontario, L8N 3Z5
    JAMA 286:421-6. 2001
    ..Microalbuminuria is a risk factor for cardiovascular (CV) events. The relationship between the degree of albuminuria and CV risk is unclear...
  59. ncbi request reprint Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
    S Yusuf
    Canadian Cardiovascular Collaboration Project Office, Hamilton General Hospital, McMaster University, ON
    N Engl J Med 342:145-53. 2000
    ..We assessed the role of an angiotensin-converting-enzyme inhibitor, ramipril, in patients who were at high risk for cardiovascular events but who did not have left ventricular dysfunction or heart failure...
  60. doi request reprint Potentially modifiable risk factors associated with myocardial infarction in China: the INTERHEART China study
    K K Teo
    Population Health Research Institute, McMaster University Hamilton Health Sciences, Hamilton, Ontario, Canada
    Heart 95:1857-64. 2009
    ..Lifestyle changes associated with the rapidly developing economy increase cardiovascular disease (CVD), myocardial infarction (MI) and cardiovascular risk factors (CVRFs) in China...
  61. ncbi request reprint The relationship between dysglycaemia and cardiovascular and renal risk in diabetic and non-diabetic participants in the HOPE study: a prospective epidemiological analysis
    H C Gerstein
    McMaster University and Population Health Research Institute, Hamilton, Ontario, Canada
    Diabetologia 48:1749-55. 2005
    ....
  62. doi request reprint Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial
    Shamir R Mehta
    McMaster University and Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    Lancet 376:1233-43. 2010
    ..We assessed the effect of various clopidogrel and aspirin regimens in prevention of major cardiovascular events and stent thrombosis in patients undergoing PCI...
  63. ncbi request reprint Impact of candesartan on nonfatal myocardial infarction and cardiovascular death in patients with heart failure
    Catherine Demers
    McMaster University, Hamilton, Ontario, Canada
    JAMA 294:1794-8. 2005
    ..Angiotensin-converting enzyme (ACE) inhibitors reduce the risk of myocardial infarction (MI), but it is not known whether angiotensin receptor blockers have the same effect...
  64. ncbi request reprint Impact of right ventricular involvement on mortality and morbidity in patients with inferior myocardial infarction
    S R Mehta
    Division of Cardiology, Hamilton Health Sciences Corporation, McMaster University, Ontario, Canada
    J Am Coll Cardiol 37:37-43. 2001
    ..We sought to evaluate the prognostic impact of right ventricular (RV) myocardial involvement in patients with inferior myocardial infarction (MI)...
  65. ncbi request reprint Prognostic significance of thrombocytopenia during hirudin and heparin therapy in acute coronary syndrome without ST elevation: Organization to Assess Strategies for Ischemic Syndromes (OASIS-2)study
    J W Eikelboom
    Preventive Cardiology and Therapeutics Program, McMaster University, Hamilton, Canada
    Circulation 103:643-50. 2001
    ..The excess of major bleeding in hirudin-treated patients who develop thrombocytopenia suggests that thrombocytopenia may contribute to the increased risk of bleeding observed with hirudin...
  66. ncbi request reprint Relationship of current and past smoking to mortality and morbidity in patients with left ventricular dysfunction
    N Suskin
    Division of Cardiology, London Health Science Center, Ontario, Canada
    J Am Coll Cardiol 37:1677-82. 2001
    ....
  67. doi request reprint Dysglycaemia and the risk of acute myocardial infarction in multiple ethnic groups: an analysis of 15,780 patients from the INTERHEART study
    H C Gerstein
    The Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada
    Diabetologia 53:2509-17. 2010
    ..Although diabetes is an established risk factor for myocardial infarction (MI), disease control may vary. HbA(1c) is a reliable index of ambient glucose levels and may provide more information on MI risk than diabetes status...
  68. doi request reprint Metabolic syndrome and risk of acute myocardial infarction a case-control study of 26,903 subjects from 52 countries
    Andrew Mente
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    J Am Coll Cardiol 55:2390-8. 2010
    ..This study examines the risk of acute myocardial infarction (MI) conferred by the metabolic syndrome (MS) and its individual factors in multiple ethnic populations...
  69. ncbi request reprint Unfractionated and low-molecular-weight heparin as adjuncts to thrombolysis in aspirin-treated patients with ST-elevation acute myocardial infarction: a meta-analysis of the randomized trials
    John W Eikelboom
    General Division, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Circulation 112:3855-67. 2005
    ..There is uncertainty about the role of intravenous unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH) in patients with ST-elevation myocardial infarction (STEMI) treated with aspirin and thrombolysis...
  70. ncbi request reprint Usefulness of temporal changes in neurohormones as markers of ventricular remodeling and prognosis in patients with left ventricular systolic dysfunction and heart failure receiving either candesartan or enalapril or both
    Raymond T Yan
    The University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 96:698-704. 2005
    ..Serial measurements of these neurohormones may serve as useful surrogate markers of ventricular remodeling and prognosticators for clinical risk stratification...
  71. ncbi request reprint Oral anticoagulant therapy in patients with coronary artery disease: a meta-analysis
    S S Anand
    Program of Preventive Cardiology and Therapeutics, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario, Canada
    JAMA 282:2058-67. 1999
    ..Despite years of use in coronary artery disease (CAD) and several studies of its effectiveness, the role of oral anticoagulants (OAs) remains controversial...
  72. ncbi request reprint Enalapril prevents clinical proteinuria in diabetic patients with low ejection fraction
    S E Capes
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 23:377-80. 2000
    ..The prevalence of clinical proteinuria, its correlates and predictive value, and the effect of ACE inhibitors in preventing clinical proteinuria in diabetic and nondiabetic patients with left ventricular (LV) dysfunction are unknown...
  73. pmc Rationale, design and baseline characteristics of a large, simple, randomized trial of combined folic acid and vitamins B6 and B12 in high-risk patients: the Heart Outcomes Prevention Evaluation (HOPE)-2 trial
    E Lonn
    Hamilton Health Sciences Corporation, Hamilton, Ontario
    Can J Cardiol 22:47-53. 2006
    ..Therefore, a large, randomized clinical trial--the Heart Outcomes Prevention Evaluation (HOPE)-2 study--is being conducted to evaluate this therapy in patients at high risk for CV events...
  74. ncbi request reprint Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial
    S Connolly
    Health Research Institute, Hamilton, ON, Canada
    Lancet 367:1903-12. 2006
    ..However, long-term monitoring is necessary and many patients cannot achieve optimum anticoagulation. We assessed whether clopidogrel plus aspirin was non-inferior to oral anticoagulation therapy for prevention of vascular events...
  75. ncbi request reprint Safety outcomes in meta-analyses of phase 2 vs phase 3 randomized trials: Intracranial hemorrhage in trials of bolus thrombolytic therapy
    J W Eikelboom
    McMaster University, Hamilton General Hospital McMaster Clinic, 237 Barton St E, Hamilton, Ontario, Canada L8L 2X2
    JAMA 285:444-50. 2001
    ..Recent studies have reported disagreement between meta-analysis of small trials and subsequent large trials addressing the same question. However, disagreement for uncommon but serious adverse safety outcomes has not been examined...
  76. doi request reprint Early versus delayed invasive intervention in acute coronary syndromes
    Shamir R Mehta
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 360:2165-75. 2009
    ..Earlier trials have shown that a routine invasive strategy improves outcomes in patients with acute coronary syndromes without ST-segment elevation. However, the optimal timing of such intervention remains uncertain...
  77. ncbi request reprint Reliability, validity, and responsiveness of the six-minute walk test in patients with heart failure
    C Demers
    Preventive Cardiology and Therapeutics Research Program, Division of Cardiology, Hamilton Health Sciences Corporation-General Division and McMaster University, Hamilton, Ontario, Canada
    Am Heart J 142:698-703. 2001
    ..It is somewhat correlated to NYHA-FC and quality of life. Overall, quality of life was most responsive to change, whereas 6MWT and NYHA-FC were comparable but less responsive to change in the RESOLVD study...
  78. doi request reprint Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial
    Sanjit S Jolly
    McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    Lancet 377:1409-20. 2011
    ..We aimed to assess whether radial access was superior to femoral access in patients with acute coronary syndromes (ACS) who were undergoing coronary angiography with possible intervention...
  79. doi request reprint Dabigatran versus warfarin in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 361:1139-51. 2009
    ..Warfarin reduces the risk of stroke in patients with atrial fibrillation but increases the risk of hemorrhage and is difficult to use. Dabigatran is a new oral direct thrombin inhibitor...
  80. ncbi request reprint Comparison of fondaparinux and enoxaparin in acute coronary syndromes
    Salim Yusuf
    Population Health Research Institute, McMaster Clinic, Hamilton General Hospital, 237 Barton St East, Hamilton, ON L8L 2X2, Canada
    N Engl J Med 354:1464-76. 2006
    ..We therefore assessed whether fondaparinux would preserve the anti-ischemic benefits of enoxaparin while reducing bleeding...
  81. doi request reprint Benefit of oral anticoagulant over antiplatelet therapy in atrial fibrillation depends on the quality of international normalized ratio control achieved by centers and countries as measured by time in therapeutic range
    Stuart J Connolly
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Circulation 118:2029-37. 2008
    ..This report examines how differences in time in therapeutic range (TTR) between centers and between countries affect the outcomes of OAC therapy...
  82. ncbi request reprint Interrelation of saturated fat, trans fat, alcohol intake, and subclinical atherosclerosis
    Anwar T Merchant
    Population Health Research Institute, Hamilton, Ontario, Canada
    Am J Clin Nutr 87:168-74. 2008
    ..Intake of saturated fat, trans fat, and alcohol alter cardiovascular disease risk, but their effect on subclinical atherosclerosis remains understudied...
  83. ncbi request reprint Tobacco use and risk of myocardial infarction in 52 countries in the INTERHEART study: a case-control study
    Koon K Teo
    Population Health Research Institute, McMaster University Hamilton Health Sciences, Hamilton, ON L8L 2X2, Canada
    Lancet 368:647-58. 2006
    ..Tobacco use is one of the major avoidable causes of cardiovascular diseases. We aimed to assess the risks associated with tobacco use (both smoking and non-smoking) and second hand tobacco smoke (SHS) worldwide...
  84. ncbi request reprint Rationale, design and recruitment characteristics of a large, simple international trial of diabetes prevention: the DREAM trial
    H C Gerstein
    Population Health Research Institute, Hamilton, Ontario, Canada
    Diabetologia 47:1519-27. 2004
    ..This risk can be reduced by lifestyle changes and/or various drugs. Novel therapies to prevent diabetes, as well as new risk factors for diabetes, atherosclerosis and obesity require testing and identification...
  85. ncbi request reprint Validity of the US Behavioral Risk Factor Surveillance System's health related quality of life survey tool in a group of older Canadians
    S Ounpuu
    Population Health Section, Hamilton General Hospital, McMaster Clinic and Department of Medicine, McMaster University, 237 Barton Street East, Hamilton, Ontario L8L 2X2
    Chronic Dis Can 22:93-101. 2001
    ..This study demonstrated that the HRQOL-4 is not only accepted by older adults in a self-administered format, but also stands up to tests of its validity...
  86. ncbi request reprint INTER-HEART: A global study of risk factors for acute myocardial infarction
    S Ounpuu
    Canadian Cardiovascular Collaboration, McMaster University, Canada
    Am Heart J 141:711-21. 2001
    ..This has ensured the feasibility of INTER-HEART. This study has the potential to have a major impact in developing a worldwide strategy for cardiovascular disease prevention, especially in developing countries and nonwhite populations...
  87. ncbi request reprint Low rates of preventive practices in patients with peripheral vascular disease
    S S Anand
    Hamilton Civic Hospitals Research Centre, McMaster University, Hamilton, Canada
    Can J Cardiol 15:1259-63. 1999
    ..Given the scarcity of data on the preventive practice patterns of this high risk patient group, the in-hospital management of patients admitted to hospital for a peripheral vascular intervention was reviewed...
  88. ncbi request reprint Effect of ramipril on the incidence of diabetes
    Jackie Bosch
    McMaster University, Hamilton, Canada
    N Engl J Med 355:1551-62. 2006
    ..Previous studies have suggested that blockade of the renin-angiotensin system may prevent diabetes in people with cardiovascular disease or hypertension...
  89. doi request reprint Dietary patterns and the risk of acute myocardial infarction in 52 countries: results of the INTERHEART study
    Romaina Iqbal
    Population Health Research Institute, Michael deGroote School of Medicine, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
    Circulation 118:1929-37. 2008
    ..The objectives of the present study were to assess the association between dietary patterns and acute myocardial infarction (AMI) globally...
  90. ncbi request reprint Relationship of the ApoE polymorphism to plasma lipid traits among South Asians, Chinese, and Europeans living in Canada
    Debika Burman
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada
    Atherosclerosis 203:192-200. 2009
    ..We examined the apolipoprotein E (ApoE) polymorphism, its association with lipid traits and atherosclerosis, and its influence on ethnic variations on lipid traits...
  91. ncbi request reprint Prevalence of mitral valve prolapse in ethnic groups
    Michael Theal
    Department of Medicine and Population Health Research Institute, McMaster University, Hamilton, Canada
    Can J Cardiol 20:511-5. 2004
    ..From a population perspective, the prevalence of serious cardiovascular complications associated with MVP is low...
  92. ncbi request reprint Clinical decisions. Management of stable coronary disease
    Salim Yusuf
    McMaster University, Hamilton, ON, Canada
    N Engl J Med 357:1762-6. 2007
  93. doi request reprint Association of diet, exercise, and smoking modification with risk of early cardiovascular events after acute coronary syndromes
    Clara K Chow
    Hamilton General Hospital, 237 Barton St E, Hamilton, Ontario, L8L 2X2, Canada
    Circulation 121:750-8. 2010
    ..The aim of this study was to examine the influence of adherence to behavioral recommendations in the short term on risk of cardiovascular events...
  94. doi request reprint Cardiovascular risk factors and non-invasive assessment of subclinical atherosclerosis in youth
    K M Morrison
    Mc Master University, HSC 3A59, 1200 Main Street W, Hamilton, ON, L8N 3Z5, Canada
    Atherosclerosis 208:501-5. 2010
    ..The age at which vascular changes can be reliably identified using IMT and the influence of CV risk factors beyond FH on IMT remains unclear...
  95. ncbi request reprint Global burden of cardiovascular diseases: Part II: variations in cardiovascular disease by specific ethnic groups and geographic regions and prevention strategies
    S Yusuf
    Population Health Research Institute and Division of Cardiology, McMaster University, Hamilton, Ontario, Canada
    Circulation 104:2855-64. 2001
    ..Part II of this article describes the burden of CV disease by specific region or ethnic group, the risk factors of importance, and possible strategies for prevention...
  96. ncbi request reprint The relevance of subgroup-specific treatment effects: the Studies Of Left Ventricular Dysfunction (SOLVD) revisited
    Andrea B Parker
    Institute of Medical Sciences, University of Toronto, and Cardiac Research Inc, Toronto, Ontario, Canada
    Am Heart J 144:941-7. 2002
    ..We reanalyzed the Studies of Left Ventricular Dysfunction (SOLVD) to determine whether the treatment effect depended on the patients' baseline prognosis, defined on the basis of multiple clinical variables...
  97. doi request reprint Glucose levels compared with diabetes history in the risk assessment of patients with acute myocardial infarction
    Abhinav Goyal
    Population Health Research Institute, Hamilton Health Sciences, Ontario, Canada
    Am Heart J 157:763-70. 2009
    ..Both a history of diabetes mellitus and elevated inhospital glucose levels predict death after acute myocardial infarction (AMI). However, only diabetes history (and not glucose levels) is routinely considered in AMI risk assessment...
  98. doi request reprint Effects of aspirin dose on ischaemic events and bleeding after percutaneous coronary intervention: insights from the PCI-CURE study
    Sanjit S Jolly
    Department of Medicine, McMaster University and Population Health Research Institute, Hamilton Health Sciences, Hamilton, Canada
    Eur Heart J 30:900-7. 2009
    ..In the setting of percutaneous coronary intervention (PCI), due to a paucity of data, the optimal dose of aspirin is uncertain. We evaluated the safety of different doses of aspirin after PCI...
  99. ncbi request reprint Clinical research and trials in developing countries
    Salim Yusuf
    McMaster University, Hamilton, Ontario, Canada
    Stat Med 21:2859-67. 2002
    ....
  100. ncbi request reprint Oral anticoagulant therapy in patients with coronary artery disease
    Daniel G Hackam
    Department of MedicineMcMaster University, Hamilton, Ontario, Canada
    Semin Vasc Med 3:323-32. 2003
    ..0 to 3.0) should be considered an option for the prevention of recurrent CAD, particularly in high-risk patients...
  101. ncbi request reprint Reevaluation by high-performance liquid chromatography: clinical significance of microalbuminuria in individuals at high risk of cardiovascular disease in the Heart Outcomes Prevention Evaluation (HOPE) Study
    Matthew J McQueen
    Hamilton Regional Laboratory Medicine Program, Department of Pathology, Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Am J Kidney Dis 48:889-96. 2006
    ..Conventional immunoassays may underestimate albuminuria by not detecting a mildly denatured unfragmented form of albumin, immunounreactive to conventional antibodies...