L T Young

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi Mood stabilizers have differential effects on endogenous ADP ribosylation in C6 glioma cells
    L T Young
    Department of Psychiatry, McMaster University, Hamilton, Ontario, Canada
    Eur J Pharmacol 309:215-8. 1996
  2. ncbi Stimulatory G-protein alpha-subunit mRNA levels are not increased in autopsied cerebral cortex from patients with bipolar disorder
    L T Young
    Department of Psychiatry, McMaster University, Hamilton, ONT Canada
    Brain Res Mol Brain Res 42:45-50. 1996
  3. ncbi Platelet protein kinase C alpha levels in drug-free and lithium-treated subjects with bipolar disorder
    L T Young
    Mood Disorder Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ont, Canada
    Neuropsychobiology 40:63-6. 1999
  4. ncbi Gabapentin as an adjunctive treatment in bipolar disorder
    L T Young
    Department of Psychiatry, McMaster University, Hamilton, Ontario, Canada
    J Affect Disord 55:73-7. 1999
  5. ncbi Double-blind comparison of addition of a second mood stabilizer versus an antidepressant to an initial mood stabilizer for treatment of patients with bipolar depression
    L T Young
    Mood Disorders Program, Hamilton Psychiatric Hospital, Hamilton, Ont, Canada
    Am J Psychiatry 157:124-6. 2000
  6. ncbi Identification of mood stabilizer-regulated genes by differential-display PCR
    J F Wang
    Department of Psychiatry and Behavioral Neuroscience, McMaster University, Hamilton, Ontario, Canada
    Int J Neuropsychopharmacol 4:65-74. 2001
  7. ncbi The effect of mood stabilizer lithium on expression and activity of glutathione s-transferase isoenzymes
    L Shao
    Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, British Columbia, Canada
    Neuroscience 151:518-24. 2008
  8. ncbi Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication
    B Chen
    Department of Psychiatry and Behavioral Neuroscience, McMaster University, Hamilton, Ontario, Canada
    Biol Psychiatry 50:260-5. 2001
  9. ncbi Attenuation of N-methyl-D-aspartate-mediated cytoplasmic vacuolization in primary rat hippocampal neurons by mood stabilizers
    C D Bown
    Mood Disorders Program, Department of Psychiatry, 1200 Main Street West, McMaster University, L8N 3Z5, Hamilton, Ontario, Canada
    Neuroscience 117:949-55. 2003
  10. ncbi Abnormalities in the cAMP signaling pathway in post-mortem brain tissue from the Stanley Neuropathology Consortium
    R J Stewart
    Mood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Brain Res Bull 55:625-9. 2001

Collaborators

Detail Information

Publications30

  1. ncbi Mood stabilizers have differential effects on endogenous ADP ribosylation in C6 glioma cells
    L T Young
    Department of Psychiatry, McMaster University, Hamilton, Ontario, Canada
    Eur J Pharmacol 309:215-8. 1996
    ..These results also suggest that lithium salts and the anticonvulsant mood stabilizers may have distinct mechanisms of action...
  2. ncbi Stimulatory G-protein alpha-subunit mRNA levels are not increased in autopsied cerebral cortex from patients with bipolar disorder
    L T Young
    Department of Psychiatry, McMaster University, Hamilton, ONT Canada
    Brain Res Mol Brain Res 42:45-50. 1996
    ..Cerebral cortex alpha s mRNA levels did not correlate with age or postmortem interval. These findings do not support the notion that higher alpha s levels found in BD postmortem brain are a result of increased gene expression...
  3. ncbi Platelet protein kinase C alpha levels in drug-free and lithium-treated subjects with bipolar disorder
    L T Young
    Mood Disorder Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ont, Canada
    Neuropsychobiology 40:63-6. 1999
    ..The present study suggests that levels of PKC-alpha do not change in the peripheral tissues of BD subjects with or without lithium treatment...
  4. ncbi Gabapentin as an adjunctive treatment in bipolar disorder
    L T Young
    Department of Psychiatry, McMaster University, Hamilton, Ontario, Canada
    J Affect Disord 55:73-7. 1999
    ..To evaluate the efficacy of gabapentin as an adjunctive treatment for bipolar disorder in both depressed and manic phases...
  5. ncbi Double-blind comparison of addition of a second mood stabilizer versus an antidepressant to an initial mood stabilizer for treatment of patients with bipolar depression
    L T Young
    Mood Disorders Program, Hamilton Psychiatric Hospital, Hamilton, Ont, Canada
    Am J Psychiatry 157:124-6. 2000
    ..This study's purpose was to clarify the appropriate treatment of bipolar depression by comparing the addition of an antidepressant versus a second mood stabilizer for inpatients being treated with lithium carbonate or divalproex sodium...
  6. ncbi Identification of mood stabilizer-regulated genes by differential-display PCR
    J F Wang
    Department of Psychiatry and Behavioral Neuroscience, McMaster University, Hamilton, Ontario, Canada
    Int J Neuropsychopharmacol 4:65-74. 2001
    ..The data further our understanding of the mechanism of the action of mood stabilizers, and help identify new targets for genetic studies and therapeutic strategies in bipolar disorder...
  7. ncbi The effect of mood stabilizer lithium on expression and activity of glutathione s-transferase isoenzymes
    L Shao
    Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, British Columbia, Canada
    Neuroscience 151:518-24. 2008
    ....
  8. ncbi Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication
    B Chen
    Department of Psychiatry and Behavioral Neuroscience, McMaster University, Hamilton, Ontario, Canada
    Biol Psychiatry 50:260-5. 2001
    ..CONCLUSIONS: These findings are consistent with recent studies measuring CREB levels in this same subject sample, and support current animal and cellular models of antidepressant function...
  9. ncbi Attenuation of N-methyl-D-aspartate-mediated cytoplasmic vacuolization in primary rat hippocampal neurons by mood stabilizers
    C D Bown
    Mood Disorders Program, Department of Psychiatry, 1200 Main Street West, McMaster University, L8N 3Z5, Hamilton, Ontario, Canada
    Neuroscience 117:949-55. 2003
    ..These results suggest that inhibition of neurotoxicity may be involved in the action of mood stabilizers...
  10. ncbi Abnormalities in the cAMP signaling pathway in post-mortem brain tissue from the Stanley Neuropathology Consortium
    R J Stewart
    Mood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Brain Res Bull 55:625-9. 2001
    ..The relations between changes in second messenger systems, gene transcription, and clinical effects of current therapeutic regimens has implications for development of novel treatments of mood disorders...
  11. ncbi Group cognitive behavioral therapy for bipolar disorder: a feasibility and effectiveness study
    I Patelis-Siotis
    Hamilton Psychiatric Hospital, Mood Disorders Program, 100 West 5th St, Hamilton, Ontario L8N 3K7, Canada
    J Affect Disord 65:145-53. 2001
    ..Despite the fact that mood symptoms were controlled at entry into the study, psychosocial functioning increased significantly at the end of treatment. Adjunctive CBT should be further investigated in this population...
  12. ncbi Differential effects of mood stabilizers on Fos/Jun proteins and AP-1 DNA binding activity in human neuroblastoma SH-SY5Y cells
    V Asghari
    Department of Psychiatry, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    Brain Res Mol Brain Res 58:95-102. 1998
    ..The present results confirm and extend previous findings on the regulation of c-fos expression and AP-1 binding after administration of mood stabilizers, and further elucidate the mechanisms through which VPA increases AP-1 DNA binding...
  13. ncbi Gene expression differences in bipolar disorder revealed by cDNA array analysis of post-mortem frontal cortex
    Y B Bezchlibnyk
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Neurochem 79:826-34. 2001
    ..Given the neuroprotective role attributed to this inhibitory cytokine, our results suggest that the down-regulation of TGF-beta 1 may lead to various neurotoxic insults potentially involved in the etiology of certain mood disorders...
  14. ncbi Relationship between the five-factor model of personality and unipolar, bipolar and schizophrenic patients
    R M Bagby
    Clarke Institute of Psychiatry, Toronto, Ontario, Canada
    Psychiatry Res 70:83-94. 1997
    ..The schizophrenic patients scored lower on the Feelings, Values and Actions facets of O than did the unipolar and bipolar patients. The unipolar patients scored higher on A than the schizophrenic patients...
  15. ncbi A two-illness model of bipolar disorder
    R T Joffe
    Department of Psychiatry, McMaster University, Hamilton, Ontario, Canada
    Bipolar Disord 1:25-30. 1999
    ..Studies of clinical syndromes, course of illness, family history and genetics, biological factors, and treatment response data directly or indirectly support this new model...
  16. ncbi Induction of mania and cycle acceleration in bipolar disorder: effect of different classes of antidepressant
    R T Joffe
    Regional Mood Disorders Program, Department of Psychiatry and Behavioral Neuroscience, McMaster University, Hamilton, Ontario, Canada
    Acta Psychiatr Scand 105:427-30. 2002
    ..There is, however, the suggestion that certain classes of antidepressants may be less likely than others to cause these unwanted effects...
  17. ncbi Chronic valproate treatment increases expression of endoplasmic reticulum stress proteins in the rat cerebral cortex and hippocampus
    B Chen
    Department of Psychiatry and Behavioral Neuroscience, McMaster University, Hamilton, Canada
    Biol Psychiatry 48:658-64. 2000
    ..In our study, we investigated the effect of this drug on the other members of the endoplasmic reticulum stress protein family, GRP94 and calreticulin, and we studied the brain regional distribution of GRP78, GRP94, and calreticulin...
  18. ncbi Backward masking task performance in stable, euthymic out-patients with bipolar disorder
    G M MacQueen
    Mood Disorders Program, McMaster University, Hamilton, Ontario, Canada
    Psychol Med 31:1269-77. 2001
    ....
  19. ncbi Performance of heterozygous brain-derived neurotrophic factor knockout mice on behavioral analogues of anxiety, nociception, and depression
    G M MacQueen
    Department of Psychiatry and Behavioral Neurosciences, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Behav Neurosci 115:1145-53. 2001
    ..Overall, heterozygous mice were not more likely to display anxious or depressive-like behaviors and, consequently, may not constitute a murine model of genetic vulnerability to mood and anxiety disorders...
  20. ncbi Is lithium response related to G(s)alpha levels in transformed lymphoblasts from subjects with bipolar disorder?
    M Alda
    Department of Psychiatry, Dalhousie University, Halifax, Canada
    J Affect Disord 65:117-22. 2001
    ..Long-term lithium administration blunts G-protein coupled cAMP signaling and may regulate G(s)alpha levels...
  21. ncbi Decreased mRNA expression of uncoupling protein 2, a mitochondrial proton transporter, in post-mortem prefrontal cortex from patients with bipolar disorder and schizophrenia
    A D Gigante
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Neurosci Lett 505:47-51. 2011
    ..Although more studies are necessary, our results suggest that UCP2 is not been used as a compensatory mechanism to oppose the higher levels of oxidative stress found in BD and SCZ...
  22. ncbi Lithium treatment prevents stress-induced dendritic remodeling in the rodent amygdala
    S A Johnson
    Department of Psychology, University of Toronto, 100 St George Street, Toronto, Ontario, Canada
    Neuroscience 163:34-9. 2009
    ..This may reflect an ability of lithium to stabilize excitatory neurotransmission in the amygdala of individuals with BD, reducing the need for compensatory adjustments of dendritic architecture...
  23. ncbi A review of psychosocial outcome in patients with bipolar disorder
    G M MacQueen
    Mood Disorders Program, McMaster University, Hamilton, Ontario, Canada
    Acta Psychiatr Scand 103:163-70. 2001
    ....
  24. ncbi Valproate inhibits oxidative damage to lipid and protein in primary cultured rat cerebrocortical cells
    J F Wang
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada L8N 3Z5
    Neuroscience 116:485-9. 2003
    ....
  25. ncbi Family-of-origin characteristics in bipolar disorder: a controlled study
    R G Cooke
    Department of Psychiatry, University of Toronto, Ontario
    Can J Psychiatry 44:379-81. 1999
    ..To assess the family-of-origin characteristics of patients with bipolar disorder relative to those of control subjects...
  26. ncbi Differential display polymerase chain reaction reveals increased expression of striatal rat glia-derived nexin following chronic clozapine treatment
    V Z Chong
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    Pharmacogenomics J 4:379-87. 2004
    ..This study presents a possible neuroprotective role of nexin in clozapine treatment, particularly in the prevention of neuronal proteolytic degradation, since nexin has been shown to be a protease inhibitor...
  27. ncbi Bipolar II disorder: symptoms, course, and response to treatment
    G M MacQueen
    McMaster University, McMaster University Medical Center, Hamilton, Ontario, Canada
    Psychiatr Serv 52:358-61. 2001
    ..Preliminary studies suggest that the newer anticonvulsants may be of benefit for patients with bipolar II disorder, while other data suggest that there may be a greater role for antidepressant medications...
  28. ncbi Recollection memory deficits in patients with major depressive disorder predicted by past depressions but not current mood state or treatment status
    G M MacQueen
    Mood Disorders Program, McMaster University, Hamilton, Ontario, Canada
    Psychol Med 32:251-8. 2002
    ..The memory deficits were independent of current mood state but related to past course of illness and significant enough that patients detected impairment in day-to-day memory function...
  29. ncbi Postreceptor pathways for signal transduction in depression and bipolar disorder
    L T Young
    Regional Mood Disorders Program, Department of Psychiatry, McMaster University, Hamilton, Ont
    J Psychiatry Neurosci 26:S17-22. 2001
    ..The results of a wide range of research in this area, along with the hypotheses now under investigation, are summarized in this paper...
  30. ncbi Role of glutathione in neuroprotective effects of mood stabilizing drugs lithium and valproate
    J Cui
    The Vivian Rakoff Mood Disorders Laboratory, Centre for Addiction and Mental Health, 250 College Street, 11th Floor, Toronto, Ontario, Canada M5T 1R8
    Neuroscience 144:1447-53. 2007
    ..These results suggest that glutathione plays an important role in the neuroprotective effects of lithium and valproate, and that glutathione may be a common target for mood stabilizing drugs...