Research Topics
| Jianping XuSummaryAffiliation: McMaster University Country: Canada Publications
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Publications
Multiple origins of hybrid strains of Cryptococcus neoformans with serotype ADJianping Xu
Department of Biology, McMaster University, Hamilton, Ontario, L8S 4K1, Canada
Microbiology 148:203-12. 2002..The results demonstrate that the evolution of C. neoformans is continuing and dynamic...- Extracting haplotypes from diploid organismsJianping Xu
Department of Biology, McMaster University, 1280 Main St West, Hamilton, Ontario, L8S 4K1, Canada
Curr Issues Mol Biol 8:113-22. 2006..With increasing sophistication in both bioinformatics tools and high-throughput molecular techniques, haplotype analysis is becoming an integrated component in biomedical research... 
Recombination and genetic differentiation among natural populations of the ectomycorrhizal mushroom Tricholoma matsutake from southwestern ChinaJianping Xu
Key Laboratory of Biodiversity and Biogeography, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650204, China
Mol Ecol 17:1238-47. 2008..We discuss the implications of our results to the ecology and resource management of this species...- Quantitative variation of biofilms among strains in natural populations of Candida albicansXiaogang Li
Department of Biology, McMaster University, 1280 Main St West, Hamilton, Ontario, Canada L8S 4K1
Microbiology 149:353-62. 2003..The results demonstrated that natural clones and clonal lineages of C. albicans exhibited extensive quantitative variation in biofilm formation... - Divergence, hybridization, and recombination in the mitochondrial genome of the human pathogenic yeast Cryptococcus gattiiJianping Xu
Department of Biology, and Institute of Infectious Disease Research, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada L8S 4K1
Mol Ecol 18:2628-42. 2009..Our analyses suggest historical mitochondrial genome divergence within C. gattii, but there is evidence for recent hybridization and recombination in the mitochondrial genome of this important human yeast pathogen... 
Estimating the spontaneous mutation rate of loss of sex in the human pathogenic fungus Cryptococcus neoformansJianping Xu
Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
Genetics 162:1157-67. 2002..0172 and 0.0036, respectively. The results show that C. neoformans can be a highly attractive model for analyses of reproductive system evolution in fungi...- Mitochondrial DNA polymorphisms in the human pathogenic fungus Cryptococcus neoformansJianping Xu
Department of Biology, LSB437, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada
Curr Genet 41:43-7. 2002..These results were discussed in the context of recent findings regarding the origins of serotype AD strains and the observed uniparental mtDNA inheritance in laboratory crosses between strains of serotypes A and D... - The prevalence and evolution of sex in microorganismsJianping Xu
Department of Biology, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada
Genome 47:775-80. 2004..It is argued that microbes are excellent model organisms to explore the mechanisms responsible for the evolution of sex... - Fine-scale genetic analyses reveal unexpected spatial-temporal heterogeneity in two natural populations of the commercial mushroom Agaricus bisporusJianping Xu
Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1
Microbiology 148:1253-62. 2002..The results demonstrated spatial-temporal genetic heterogeneity of A. bisporus in natural populations... - Genotype-environment interactions of spontaneous mutations for vegetative fitness in the human pathogenic fungus Cryptococcus neoformansJianping Xu
Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
Genetics 168:1177-88. 2004..neoformans were consistent with laboratory experimental population analyses. This study calls into question our long-standing view that warm-blooded mammals were only occasional and accidental hosts of this human fungal pathogen... - Fundamentals of fungal molecular population genetic analysesJianping Xu
Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada
Curr Issues Mol Biol 8:75-89. 2006..These developments are bringing fungal population and evolutionary genetics into mainstream ecology and evolutionary biology... - Molecular, developmental, and evolutionary genetic studies highlight rapid evolution of genes and genetic systemsJianping Xu
Department of Biology, McMaster University, Hamilton, ON, Canada
Genome 53:848-52. 2010..The combined molecular, developmental, and evolutionary genetic investigations presented at the meeting, especially those on model organisms, highlighted that genes and genetic systems can evolve very rapidly... - The inheritance of organelle genes and genomes: patterns and mechanismsJianping Xu
Department of Biology, McMaster University, Hamilton, ON, Canada
Genome 48:951-8. 2005.... - Single nucleotide polymorphisms in the ectomycorrhizal mushroom Tricholoma matsutakeJianping Xu
Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People s Republic of China
Microbiology 153:2002-12. 2007..The implications of these SNPs and haplotypes for our understanding of the genetics, population history, ecology and evolution of this important mushroom species are discussed... - Cost of interacting with sexual partners in a facultative sexual microbeJianping Xu
Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
Genetics 171:1597-604. 2005..This cost must have been compensated for by the production of zygotes and sexual spores to allow the initial evolution and spread of sexual reproduction in eukaryotes... - Dynamic and heterogeneous mutations to fluconazole resistance in Cryptococcus neoformansJ Xu
Department of Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Antimicrob Agents Chemother 45:420-7. 2001..These results suggest that dynamic and heterogeneous mutational processes are involved in generating fluconazole resistance in C. neoformans... - Microbial ecology in the age of genomics and metagenomics: concepts, tools, and recent advancesJianping Xu
Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada
Mol Ecol 15:1713-31. 2006..The integration of various levels of ecological analyses coupled to the application and further development of high throughput technologies are accelerating the pace of discovery in microbial ecology... - Comparative gene genealogical analyses of strains of serotype AD identify recombination in populations of serotypes A and D in the human pathogenic yeast Cryptococcus neoformansJianping Xu
Department of Biology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
Microbiology 149:2147-54. 2003..The results suggest recombination in natural populations of both serotypes A and D... - Genetic analyses of a hybrid cross between serotypes A and D strains of the human pathogenic fungus Cryptococcus neoformansSheng Sun
Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
Genetics 177:1475-86. 2007..We discuss the implications of our results in our understanding of the speciation and evolution of the C. neoformans species complex... - Prevalence of specific and phylogenetically closely related genotypes in the population of Candida albicans associated with genital candidiasis in ChinaShu Hua Ge
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Fungal Genet Biol 49:86-93. 2012..The results suggest significant association of specific and genetically similar genotypes with genital infections in China... - Multiple gene genealogical analyses suggest divergence and recent clonal dispersal in the opportunistic human pathogen Candida guilliermondiiLisa Lan
Department of Biology, McMaster University, 1280 Main St West, Hamilton, ON L8S 4K1, Canada
Microbiology 152:1539-49. 2006..guilliermondii and C. fermentati. The multiple gene genealogical analyses conducted here revealed significant divergence and clonal dispersal in this important pathogenic yeast complex... - Correlation between azole susceptibilities, genotypes, and ERG11 mutations in Candida albicans isolates associated with vulvovaginal candidiasis in ChinaShu Hua Ge
Institute of Microbiology, Chinese Academy of Sciences, No 1 West Beichen Road, Chaoyang District, Beijing 100101, China
Antimicrob Agents Chemother 54:3126-31. 2010..The correlation between azole susceptibility and C. albicans genotype may be of potential therapeutic significance... - Mitochondrial inheritance in haploid x non-haploid crosses in Cryptococcus neoformansIrina Skosireva
Department of Biology, Institute of Infectious Disease Research, Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON L8S 4K1, Canada
Curr Genet 56:163-76. 2010..Flow cytometry analysis revealed that meiotic progeny population of each cross was of mixed ploidy while the ploidy level of the selected fusants ranged from diploid to triploid... - Torulaspora quercuum sp. nov. and Candida pseudohumilis sp. nov., novel yeasts from human and forest habitatsQi Ming Wang
Systematic Mycology and Lichenology Laboratory, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
FEMS Yeast Res 9:1322-6. 2009..nov. is proposed for strain XZ-281(T) (=AS 2.3956(T)=CBS 11404(T)) and a teleomorphic name Torulaspora quercuum sp. nov. is proposed for strain 17YF(T) (=AS 2.3768(T)=CBS 11403(T)) and the other three oral strains... - Prevalent nosocomial clusters among causative agents for candidemia in Hamilton, CanadaHarinad Maganti
Department of Biology, McMaster University, Hamilton, ON, Canada
Med Mycol 49:530-8. 2011..Our results indicated that 33% of the patients with candidemia were infected by nosocomial clusters and suggested that measures should be taken in hospitals to prevent nosocomial acquisition of Candida infections... - Chromosomal rearrangements between serotype A and D strains in Cryptococcus neoformansSheng Sun
Department of Biology, McMaster University, Hamilton, Ontario, Canada
PLoS ONE 4:e5524. 2009..We discuss the implications of these results on the genome structure, ecology, and evolution of C. neoformans... - Genome variation in the symbiotic nitrogen-fixing bacterium Sinorhizobium melilotiHong Guo
Center for Environmental Genomics, Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada
Genome 52:862-75. 2009..Interestingly, we observed positive correlations among the three replicons in the number of absent ORFs as well as the number of duplicated ORFs, consistent with coordinated gene gains and losses in this important bacterium in nature... - Long-distance dispersal and recombination in environmental populations of Cryptococcus neoformans var. grubii from IndiaSanjay S Hiremath
Center for Environmental Genomics, Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada
Microbiology 154:1513-24. 2008..Our results are consistent with the hypothesis of long-distance dispersal and recombination in environmental populations of this species in India... - Genetic diversity of Dahongjun, the commercially important "Big Red Mushroom" from southern ChinaMochan Li
Department of Biology, McMaster University, Hamilton, Ontario, Canada
PLoS ONE 5:e10684. 2010..Although ecologically and economically important, very little is known about this mushroom, including its diversity and population structure... - Environment factors can influence mitochondrial inheritance in the fungus Cryptococcus neoformansZhun Yan
Department of Biology, McMaster University, 1280 Main St W, Hamilton, Ont, Canada L8S 4K1
Fungal Genet Biol 44:315-22. 2007..Our results indicate a potentially adaptive role of biparental mtDNA inheritance and mtDNA recombination in certain environments in C. neoformans... - Geographic distribution of mating type alleles of Cryptococcus neoformans in four areas of the United StatesZhun Yan
Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
J Clin Microbiol 40:965-72. 2002..In addition, our result demonstrate that the sample from San Francisco had a significantly higher proportion of self-fertile strains than those from the other three areas... - Multiple gene genealogical analyses reveal both common and distinct population genetic patterns among replicons in the nitrogen-fixing bacterium Sinorhizobium melilotiSheng Sun
Center for Environmental Genomics, Department of Biology, McMaster University, Hamilton, ON, Canada
Microbiology 152:3245-59. 2006..The results suggest both shared and distinct patterns of molecular evolution among the three replicons in the genomes of natural strains of S. meliloti... - The mating type-specific homeodomain genes SXI1 alpha and SXI2a coordinately control uniparental mitochondrial inheritance in Cryptococcus neoformansZhun Yan
Department of Biology, McMaster University, Hamilton, ON, Canada, L8S 4K1
Curr Genet 51:187-95. 2007..Our results suggest that SXI1alpha and SXI2a coordinately control uniparental mitochondrial inheritance in C. neoformans... - DNA sequence analyses reveal abundant diversity, endemism and evidence for Asian origin of the porcini mushroomsBang Feng
Key Laboratory of Biodiversity and Biogeography, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People s Republic of China
PLoS ONE 7:e37567. 2012..In contrast to the ancient dispersal of porcini in the strict sense in the Northern Hemisphere, the occurrence of B. reticulatus and B. edulis sensu lato in the Southern Hemisphere was probably due to recent human-mediated introductions... - Geographical differences in human oral yeast floraJianping Xu
Department of Biology, McMaster University, Hamilton, Ontario, Canada
Clin Infect Dis 36:221-4. 2003..Furthermore, Candida albicans, which is the predominant commensal and etiologic species of candidiasis in Europe and the Western Hemisphere, was relatively rare in China... - Isolation of Candida dubliniensis in an aboriginal community in Ontario, CanadaLaura Montour
Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
J Clin Microbiol 41:3423-6. 2003..dubliniensis. Genotypic analysis identified polymorphisms in these strains and differences from two reference strains. Our results suggest that yeast populations from indigenous communities in North America may be unique... - Diversity of commensal yeasts within and among healthy hostsAngela P Kam
Department of Biology, McMaster University, 1280 Main St. West, Hamilton, L8S 4K1, Ontario, Canada
Diagn Microbiol Infect Dis 43:19-28. 2002..Our results indicate dynamic processes of yeast colonization, maintenance and evolution in healthy human hosts... - Fitness distribution and transgressive segregation across 40 environments in a hybrid progeny population of the human-pathogenic yeast Cryptococcus neoformansMorvarid Shahid
Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada
Genome 51:272-81. 2008..Our study suggests that hybridization could play a significant role in the phenotypic evolution of this important human-pathogenic fungus... - Mitochondria are inherited from the MATa parent in crosses of the basidiomycete fungus Cryptococcus neoformansZhun Yan
Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
Genetics 163:1315-25. 2003..To our knowledge, this is the first demonstration that mating type controls mtDNA inheritance in fungi... - Two new unusual Leucoagaricus species (Agaricaceae) from tropical China with blue-green staining reactionsJun F Liang
Key Laboratory of Biodiversity and Biogeography, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China
Mycologia 102:1141-52. 2010..flavovirens based on morphology and ITS sequence comparison. [corrected] A monophyletic group of four bluing species from Old World tropics is recovered but with poor measures of branch.. - Candidemia in women with breast carcinoma treated with high-dose chemotherapy and autologous bone marrow transplantationMagnus Gottfredsson
Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA
Cancer 98:24-30. 2003..No systemic antifungal prophylaxis was administered. The purpose of the current study was to evaluate the risk and long-term outcome of candidemia in this patient population... - Novel DNA sequences from natural strains of the nitrogen-fixing symbiotic bacterium Sinorhizobium melilotiHong Guo
Center for Environmental Genomics, Department of Biology, McMaster University, 1280 Main St. West, Hamilton, Ontario L8S 4K1, Canada
Appl Environ Microbiol 71:7130-8. 2005..Our results suggest potentially high rates of gene gain and loss in S. meliloti genomes... - Clonal and spontaneous origins of fluconazole resistance in Candida albicansJ Xu
Department of Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Clin Microbiol 38:1214-20. 2000..The results suggest both clonal and spontaneous origins of fluconazole resistance in C. albicans... - Multiple gene genealogies reveal recent dispersion and hybridization in the human pathogenic fungus Cryptococcus neoformansJ Xu
Department of Microbiology, Duke University Medical Center, Durham, NC 27710, USA
Mol Ecol 9:1471-81. 2000..Significant incongruences were observed among gene genealogies. The analyses indicated that the major lineages in C. neoformans diverged tens of millions of years ago but have undergone recent dispersion and hybridization... - Point mutations in awdKpn which revert the prune/Killer of prune lethal interaction affect conserved residues that are involved in nucleoside diphosphate kinase substrate binding and catalysisL Timmons
Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
J Biol Chem 270:23021-30. 1995..These data suggest that an altered NDP kinase activity is involved in the mechanism underlying the conditional lethality of the awdKpn mutation... - Species and genotypic diversities and similarities of pathogenic yeasts colonizing womenJ Xu
Department of Microbiology, Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Clin Microbiol 37:3835-43. 1999..Furthermore, a single host can be colonized with multiple species or multiple genotypes of the same species at the same or different body sites, indicating dynamic processes of yeast colonization on women... - Development and characterization of a genetic linkage map of Cryptococcus neoformans var. neoformans using amplified fragment length polymorphisms and other markersA Forche
Department of Biology, Duke University, Durham, North Carolina 27708, USA
Fungal Genet Biol 31:189-203. 2000..This linkage map should provide a framework for the ongoing genome sequencing project and will be a useful tool for studying the genetics and pathogenicity of this important medical yeast... - Lack of genetic differentiation between two geographically diverse samples of Candida albicans isolated from patients infected with human immunodeficiency virusJ Xu
Department of Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Bacteriol 181:1369-73. 1999..The results indicated evidence of clonality both within and between these two geographically diverse samples. The samples are genetically very similar, with little evidence of genetic differentiation... - PCR-restriction fragment length polymorphism (RFLP) analyses reveal both extensive clonality and local genetic differences in Candida albicansJ Xu
Department of Microbiology, Duke University Medical Center, Durham, NC 27710, USA
Mol Ecol 8:59-73. 1999..Possible mechanisms are presented to explain the observed patterns of genetic variation within and between C. albicans populations... - Oral yeast flora and its ITS sequence diversity among a large cohort of medical students in Hainan, ChinaHuamin Wang
Department of Laboratory Medicine, Hainan Medical College, Haikou, Hainan, China
Mycopathologia 164:65-72. 2007..Taken together, our analyses suggest that the oral yeast flora among host populations in China is highly heterogeneous and that there is a high ITS sequence diversity in the Hainan population of C. albicans... - Molecular epidemiology of candidemia: evidence of clusters of smoldering nosocomial infectionsLena Rós Asmundsdóttir
Faculty of Medicine, University of Iceland, Reykjavik, Iceland
Clin Infect Dis 47:e17-24. 2008..The aim of this study was to investigate the molecular epidemiology of candidemia in a nationwide setting in Iceland during a 16-year period... - Abundant sequence variation around the mitochondrial origin of replication in the human opportunistic yeast pathogen Candida albicans from a tropical island in ChinaHuamin Wang
Department of Laboratory Medicine, Hainan Medical College, Haikou, Hainan, China
Fungal Genet Biol 44:991-1001. 2007..albicans mtDNA has a base substitution pattern different from its nuclear genome and that sequences from the mtOri region could enhance our understanding of C. albicans genome evolution and population structuring... - Comparative gene genealogies indicate that two clonal lineages of Cryptococcus gattii in British Columbia resemble strains from other geographical areasSarah E Kidd
School of Occupational and Environmental Hygiene, University of British Columbia, 301 2185 East Mall, Vancouver, British Columbia V6T 1Z4, Canada
Eukaryot Cell 4:1629-38. 2005..C. were also present among isolates from other areas of the world, indicating extensive strain dispersal. The nucleotide sequence diversity among isolates from B.C. was similar to that among isolates from other areas of the world... - SXI1alpha controls uniparental mitochondrial inheritance in Cryptococcus neoformansZhun Yan
Curr Biol 14:R743-4. 2004 - A polymorphic glucocorticoid receptor in a mouse population may explain inherited altered stress response and increased anxiety-type behaviorsDongsheng Xu
Department of Veterinary and Biomedical Science, University of Nebraska Lincoln, Lincoln, NE 68588 0665, USA
FASEB J 20:2414-6. 2006..These results suggest this GR polymorphism plays a role in complex mechanisms leading to lower corticosterone response to stress, and may also be associated with decreased locomotive and increased anxiety-type behaviors in mice... - Generation of rye (Secale cereale L.) plants with low transgene copy number after biolistic gene transfer and production of instantly marker-free transgenic ryeJuan Carlos Popelka
, Corrensstrasse 3, 06466 Gatersleben, Germany
Transgenic Res 12:587-96. 2003.... - Monomethyl histone H3 lysine 4 as an epigenetic mark for silenced euchromatin in ChlamydomonasKarin van Dijk
Department of Plant Pathology and Plant Science Initiative, University of Nebraska, Lincoln, Nebraska 68588 0666, USA
Plant Cell 17:2439-53. 2005..Together, our results suggest functional differentiation between dimethyl H3K4 and monomethyl H3K4, with the latter operating as an epigenetic mark for repressed euchromatin... - A simple predictive model of prolonged intensive care unit stay after surgery for acquired heart valve diseaseJianping Xu
Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Bei Jing, China
J Heart Valve Dis 16:109-15. 2007..The study aim was to construct a simple model (the Fuwai risk score) to predict prolonged intensive care unit (ICU) stay after surgery to treat acquired heart valve disease... - Encoded and enzyme-activated nanolithography of gold and magnetic nanoparticles on siliconBernhard Basnar
Institute of Chemistry and the Center of Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Langmuir 23:2293-6. 2007..The different NPs are linked to the patterns by the formation of complexes between the boronic acid residues or Fe3+ ions and the catechol ligands... - Distribution of Cryptococcus gattii and Cryptococcus neoformans in decayed trunk wood of Syzygium cumini trees in north-western IndiaH S Randhawa
Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India
Med Mycol 44:623-30. 2006..neoformans in north-western India. Attention is drawn to the likely health hazard posed by the environmental reservoirs of C. gattii and C. neoformans occurring in tree trunk hollows in proximity to human and animal habitations... - The MUT9p kinase phosphorylates histone H3 threonine 3 and is necessary for heritable epigenetic silencing in ChlamydomonasJ Armando Casas-Mollano
School of Biological Sciences and Plant Science Initiative and Department of Chemistry, University of Nebraska, Lincoln, NE 68588 0666, USA
Proc Natl Acad Sci U S A 105:6486-91. 2008..Our results suggest that H3T3ph and H3K4me1 function as reinforcing epigenetic marks for the silencing of euchromatic loci in Chlamydomonas...