Research Topics
| Gerard WrightSummaryAffiliation: McMaster University Country: Canada Publications
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Detail Information
Publications
Domain-domain interactions in the aminoglycoside antibiotic resistance enzyme AAC(6')-APH(2'')David D Boehr
Antimicrobial Research Centre, Department of Biochemistry, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada, L8N 3Z5
Biochemistry 43:9846-55. 2004..Domain-domain interactions in AAC(6')-APH(2' ') offer a unique target for inhibitor strategies, as we show that their disruption simultaneously inhibits both activities >90%...- Biochemistry. A new target for antibiotic developmentGerard D Wright
Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada, L8N 3Z5
Science 315:1373-4. 2007 
Antibiotic resistance in the environment: a link to the clinic?Gerard D Wright
M G DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada L8N 3Z5
Curr Opin Microbiol 13:589-94. 2010..Understanding the extent of the environmental resistome and its mobilization into pathogenic bacteria is essential for the management and discovery of antibiotics...- The antibiotic resistomeGerard D Wright
McMaster University, M G DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, Hamilton, ON, L8N 3Z5, Canada
Expert Opin Drug Discov 5:779-88. 2010..There is, therefore, a great interest in understanding the origins, scope and evolution of antibiotic resistance... - Antibiotic resistance is ancient: implications for drug discoveryGerard D Wright
M G DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4K1, Canada
Trends Microbiol 20:157-9. 2012..This prevalence of resistance, well before the use of antibiotics, denotes the importance of taking microbial chemical ecology and deep metagenomic profiling into account in the development and use of antibiotics... - Antibiotics: a new hopeGerard D Wright
MG DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S 4K1, Canada
Chem Biol 19:3-10. 2012..This knowledge is fueling a renaissance of interest and innovation in antibiotic discovery, synthesis, and mechanism that is poised to inform drug discovery to address pressing clinical needs... - Molecular mechanisms of antibiotic resistanceGerard D Wright
M G DeGroote Institute for Infectious Disease Research, McMaster University, 1200 Main St W, Hamilton, ON, Canada
Chem Commun (Camb) 47:4055-61. 2011..Understanding the chemical rationale and underpinnings of resistance is an essential component of our response to this clinical challenge... - Bacterial resistance to antibiotics: enzymatic degradation and modificationGerard D Wright
Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
Adv Drug Deliv Rev 57:1451-70. 2005.... 
Inactivation of the lipopeptide antibiotic daptomycin by hydrolytic mechanismsVanessa M D'Costa
M G DeGroote Institute for Infectious Disease Research, Department of Biochemistry, and Biomedical Sciences, McMaster University, Hamilton, ON, Canada
Antimicrob Agents Chemother 56:757-64. 2012....- Making sense of antisense in antibiotic drug discoveryGerard D Wright
M G DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, ON, Canada
Cell Host Microbe 6:197-8. 2009..In an era of increasing antibiotic resistance, growing clinical need for new drugs, and few lead molecules, new research is helping to identify new targets and the mechanism of action of lead molecules... - The antibiotic resistome: the nexus of chemical and genetic diversityGerard D Wright
Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, 1200 Main Street West Hamilton, Ontario, L8N 3Z5, Canada
Nat Rev Microbiol 5:175-86. 2007..Why is resistance inevitable and where does it come from? Understanding the molecular diversity that underlies resistance will inform our use of these drugs and guide efforts to develop new efficacious antibiotics... - Mechanisms of resistance to antibioticsGerard D Wright
Department of Biochemistry, McMaster University, 1200 Main St W, Hamilton, Ontario L8N 3Z5, Canada
Curr Opin Chem Biol 7:563-9. 2003.... - On the road to bacterial cell deathGerard D Wright
Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, Hamilton, ON, L8N 3Z5, Canada
Cell 130:781-3. 2007..In this issue, Kohanski et al. (2007) provide evidence that the production of reactive oxygen species is a shared mechanism of cell death initiated by bactericidal antibiotics... - New strategies for combating multidrug-resistant bacteriaGerard D Wright
Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, 1200 Main St W, Hamilton, Ontario, L8N 3Z5, Canada
Trends Mol Med 13:260-7. 2007..This new chemistry, coupled with a growing understanding of the mechanisms, origins and distribution of antibiotic resistance, position us to tackle the challenges of antibiotic resistance in the 21st century... - Chemical biology of tetracycline antibioticsBijan Zakeri
Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, 1200 Main St W, Hamilton, ON L8N3Z5, Canada
Biochem Cell Biol 86:124-36. 2008..Herein we discuss recent findings that have clarified the mode of action and the biosynthetic pathway of tetracyclines and that have shed light on the chemical biology of tetracycline antibiotics... - Streptogramin antibiotics: mode of action and resistanceNicole J Johnston
Antimicrobial Research Centre, Department of Biochemistry, McMaster University, ON, Canada
Curr Drug Targets 3:335-44. 2002..This review describes the current understanding of streptogramin function and resistance with emphasis on molecular mechanism and epidemiology... - Isolation of flavonoids from the heartwood and resin of Prunus avium and some preliminary biological investigationsJames McNulty
Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4M1
Phytochemistry 70:2040-6. 2009..The defensive role of these natural plant flavonoids as antifungal phytoalexins and phytoanticipins is discussed... - Novel approaches to discovery of antibacterial agentsPatricia L Taylor
Michael G DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St W, Hamilton, ON L8N3Z5, Canada
Anim Health Res Rev 9:237-46. 2008..Finally, inhibiting non-essential genes with small molecules is being explored as a method for rescuing the activity of 'old' antibiotics, providing a novel synergistic approach to antimicrobial discovery... - Chimeric streptogramin-tyrocidine antibiotics that overcome streptogramin resistanceTariq A Mukhtar
Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street, West Hamilton, Ontario, L8N 3Z5, Canada
Chem Biol 12:229-35. 2005..These results allow for the development of a brand new class of antibiotics with the ability to evade type B streptogramin-resistance mechanisms... - Glycopeptide antibiotic resistanceJeff Pootoolal
Antimicrobial Research Centre, Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada
Annu Rev Pharmacol Toxicol 42:381-408. 2002.... - Inhibitors of bacterial cystathionine beta-lyase: leads for new antimicrobial agents and probes of enzyme structure and functionLinda J Ejim
Antimicrobial Research Centre, McMaster High Throughput Screening Laboratory, Department of Biochemistry and Biomedical Sciences, McMaster University, Ontario L8N 3Z5, Canada
J Med Chem 50:755-64. 2007..These studies provide the first lead molecules for antimicrobial agents that target cystathionine beta-lyase in methionine biosynthesis... - Enzyme-assisted suicide: molecular basis for the antifungal activity of 5-hydroxy-4-oxonorvaline by potent inhibition of homoserine dehydrogenaseSuzanne L Jacques
Antimicrobial Research Centre and Department of Biochemistry, McMaster University, Hamilton L8N 3Z5, Canada
Chem Biol 10:989-95. 2003..These findings clarify the apparent paradox of the potent antifungal actions of HON given its weak steady-state inhibition characteristics... - Functional annotation of putative aminoglycoside antibiotic modifying proteins in Mycobacterium tuberculosis H37RvKari-ann Draker
Antimicrobial Research Centre, Department of Biochemistry, McMaster University, 1200 Main Street West, Hamilton, ON, Canada L8N 3Z5
J Antibiot (Tokyo) 56:135-42. 2003..This study demonstrates the necessity of biochemical annotation methods as a follow up to in silico sequence alignment-based methods of assigning gene product function... - Broad-spectrum peptide inhibitors of aminoglycoside antibiotic resistance enzymesDavid D Boehr
Antimicrobial Research Centre, Department of Biochemistry, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
Chem Biol 10:189-96. 2003..These peptides represent the first example of broad-spectrum inhibitors of aminoglycoside resistance enzymes... - Sampling the antibiotic resistomeKatherine M McGrann
Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, McMaster University, Ontario, Canada, L8N 3Z5
Science 311:374-7. 2006..They are a reservoir of resistance determinants that can be mobilized into the microbial community. Study of this reservoir could provide an early warning system for future clinically relevant antibiotic resistance mechanisms... - StoPK-1, a serine/threonine protein kinase from the glycopeptide antibiotic producer Streptomyces toyocaensis NRRL 15009, affects oxidative stress responseJohn M Neu
Antimicrobial Research Centre, Department of Biochemistry, McMaster University, 1200 Main St. W, Hamilton, ON, Canada, L8N 3Z5
Mol Microbiol 44:417-30. 2002..These results broaden the roles of Ser/Thr protein kinases in bacteria and underscore the diversity of signal transduction mechanisms available to respond to various stimuli... - Expanding the soil antibiotic resistome: exploring environmental diversityEmma Griffiths
Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, 1200 Main St W, Hamilton, Ontario, Canada L8N 3Z5
Curr Opin Microbiol 10:481-9. 2007..This challenges our current understanding of antibiotic resistance and provides both barriers and opportunities for antimicrobial drug discovery... - Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1Nancy L McKenzie
Department of Biochemistry and Biomedical Sciences, MG DeGroote Institute for Infectious Disease Research, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
J Antibiot (Tokyo) 63:177-82. 2010..As a result, we identified new, broad-spectrum antimicrobial activities for pulvomycin, including a potent antimicrobial activity against highly antibiotic-resistant Gram-negative and Gram-positive pathogens... - New targets and screening approaches in antimicrobial drug discoveryEric D Brown
Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
Chem Rev 105:759-74. 2005 - Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesisTariq A Mukhtar
Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
Chem Rev 105:529-42. 2005 - Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvantsPatricia L Taylor
Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
J Biol Chem 283:2835-45. 2008..We postulate GmhA acts through an enediol-intermediate isomerase mechanism... - Glycopeptide sulfation evades resistanceLindsay Kalan
M G DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
J Bacteriol 195:167-71. 2013..Our results begin to unravel the mystery of the biological role of glycopeptide sulfation and offer a potential new strategy for the development of new antibiotics that avoid resistance... - Cystathionine beta-lyase is important for virulence of Salmonella enterica serovar TyphimuriumLinda J Ejim
Antimicrobial Research Centre, Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
Infect Immun 72:3310-4. 2004..This result confirms a previous chemical validation of the Met biosynthetic pathway as a target for the development of antibacterial agents and demonstrates that cystathionine beta-lyase is important for bacterial virulence... - Structure and function of the glycopeptide N-methyltransferase MtfA, a tool for the biosynthesis of modified glycopeptide antibioticsRong Shi
Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada
Chem Biol 16:401-10. 2009..Computational docking and molecular dynamics simulations were used to model binding of demethyl-vancomycin aglycone to MtfA. These results demonstrate its utility as a tool for engineering methylated analogs of GPAs... - Multicopy suppressors for novel antibacterial compounds reveal targets and drug efflux susceptibilityXiaoming Li
Department of Biochemistry, Antimicrobial Research Centre, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
Chem Biol 11:1423-30. 2004..Two leads, which produced clones containing the gene folA, encoding dihydrofolate reductase (DHFR), proved to target DHFR in vivo and were competitive inhibitors in vitro... - Nucleotide selectivity of antibiotic kinasesTushar Shakya
M G DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
Antimicrob Agents Chemother 54:1909-13. 2010..These differences reveal likely different pathways in antibiotic resistance enzyme evolution and can be exploited in selective inhibitor design to counteract resistance... - Simultaneous in vitro assay of the first four enzymes in the fungal aspartate pathway identifies a new class of aspartate kinase inhibitorDavid C Bareich
Antimicrobial Research Centre, Department of Biochemistry, McMaster University, 1200 Main Street, West Hamilton, Ontario L8N 3Z5, Canada
Chem Biol 10:967-73. 2003 - Noncanonical vancomycin resistance cluster from Desulfitobacterium hafniense Y51Lindsay Kalan
Michael G DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street W, Hamilton, Ontario, Canada
Antimicrob Agents Chemother 53:2841-5. 2009..This finding represents a new glycopeptide antibiotic resistance gene cluster and expands the genetic diversity of resistance to this important class of antibiotic... - Molecular mechanism of the enterococcal aminoglycoside 6'-N-acetyltransferase': role of GNAT-conserved residues in the chemistry of antibiotic inactivationKari-ann Draker
Antimicrobial Research Centre, Department of Biochemistry, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
Biochemistry 43:446-54. 2004.... - Structural and kinetic characterization of the LPS biosynthetic enzyme D-alpha,beta-D-heptose-1,7-bisphosphate phosphatase (GmhB) from Escherichia coliPatricia L Taylor
Department of Biochemistry and Biomedical Sciences and M G DeGroote Institute for Infectious Disease Research, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
Biochemistry 49:1033-41. 2010..This study provides insight into the structure-function relationship of GmhB, a new target for combatting gram-negative bacterial infection... - New phenolic inhibitors of yeast homoserine dehydrogenaseLinda Ejim
Antimicrobial Research Centre, Department of Biochemistry, McMaster University, 1200 Main Street West, Hamilton, ON, Canada L8N 3Z5
Bioorg Med Chem 12:3825-30. 2004..These results provide the first nonamino acid inhibitors of this class of enzyme and have the potential to be exploited as leads in antifungal compound design... - Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of ArrJennifer Baysarowich
M G DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada L8N 3Z5
Proc Natl Acad Sci U S A 105:4886-91. 2008..This work highlights the extent of the rifamycin resistome in microbial genera with the potential to negatively impact the expanded use of this class of antibiotic... - Receptor domains of two-component signal transduction systemsJulie Perry
MG DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, 1200 Main St W, Hamilton, Ontario, Canada
Mol Biosyst 7:1388-98. 2011.... - The tetracycline resistomeMaulik Thaker
Department of Biochemistry and Biomedical Sciences, Michael G DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Canada
Cell Mol Life Sci 67:419-31. 2010.... - Kinetic mechanism of the GCN5-related chromosomal aminoglycoside acetyltransferase AAC(6')-Ii from Enterococcus faecium: evidence of dimer subunit cooperativityKari-ann Draker
Antimicrobial Research Centre, Department of Biochemistry, McMaster University, 1200 Main Street West, Ontario L8N 3Z5, Canada
Biochemistry 42:6565-74. 2003..Taken together, these results demonstrate subunit cooperativity in the AAC(6')-Ii dimer, with possible relevance to other oligomeric members of the GNAT superfamily... - Mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: role of the nucleotide positioning loopPaul R Thompson
Department of Biochemistry, Antimicrobial Research Centre, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
Biochemistry 41:7001-7. 2002..The APH NPL therefore acts as a lever, promoting phosphoryl transfer to the aminoglycoside substrate, with the biological outcome of clinically relevant antibiotic resistance... - One-pot chemoenzymatic preparation of coenzyme A analoguesIshac Nazi
Antimicrobial Research Centre, Department of Biochemistry, McMaster University, Ontario, Canada L8N 3Z5
Anal Biochem 324:100-5. 2004..The synthesis of five novel CoA derivatives is reported and the method is shown to be robust and tolerant of a number of different pantothenic acid structures, which indicates that the procedure should be widely applicable... - Small molecule functional discrimination of the kinases required for the microbial synthesis of threonine and isoleucineDavid Bareich
Antimicrobial Research Centre, Department of Biochemistry, McMaster University, 1200 Main Street W, Hamilton, Ontario, Canada L8N 3Z5
Bioorg Med Chem 12:807-15. 2004..These bisubstrate compounds only inhibited the bacterial aspartate kinase. These results reveal unexpected differences in small molecule interactions among these functionally similar enzymes... - TetX is a flavin-dependent monooxygenase conferring resistance to tetracycline antibioticsWangrong Yang
Antimicrobial Research Center, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
J Biol Chem 279:52346-52. 2004..This is the first molecular characterization of an antibiotic-inactivating monooxygenase, the origins of which may lie in environmental bacteria... - Tigecycline is modified by the flavin-dependent monooxygenase TetXIan F Moore
Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada
Biochemistry 44:11829-35. 2005.... - Biosynthesis of sulfated glycopeptide antibiotics by using the sulfotransferase StaLSherry S Lamb
Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
Chem Biol 13:171-81. 2006..This unique modification by sulfation expands glycopeptide diversity with potential application for the development of new antibiotics... - An in vitro screen of bacterial lipopolysaccharide biosynthetic enzymes identifies an inhibitor of ADP-heptose biosynthesisGladys P De Leon
Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
Chem Biol 13:437-41. 2006.... - Role of homoserine transacetylase as a new target for antifungal agentsIshac Nazi
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
Antimicrob Agents Chemother 51:1731-6. 2007..This work validates HTA as an attractive drug-susceptible target for new antifungal agent design... - Structure and mechanism of the lincosamide antibiotic adenylyltransferase LinBMariya Morar
M G DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences and the Department of Chemistry, McMaster University, Hamilton, ON L8N 3Z5, Canada
Structure 17:1649-59. 2009..The LinB structure provides an evolutionary link to ancient nucleotide polymerases and suggests that, like protein kinases and acetyltransferases, these are proto-resistance elements from which drug resistance can evolve... - Establishing the principles of recognition in the adenine-binding region of an aminoglycoside antibiotic kinase [APH(3')-IIIa]David D Boehr
Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
Biochemistry 44:12445-53. 2005..The principles governing adenine recognition established in this study may be applied to other protein-ligand complexes and used to navigate future studies directed at discovering potent and selective inhibitors of APH-type enzymes... - Accessorizing natural products: adding to nature's toolboxSherry S Lamb
Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, ON, Canada L8N 3Z5
Proc Natl Acad Sci U S A 102:519-20. 2005 - Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009Jeff Pootoolal
Antimicrobial Research Centre, Department of Biochemistry, McMaster University, Hamilton, ON, Canada L8N 3Z5
Proc Natl Acad Sci U S A 99:8962-7. 2002..These results provide increased understanding of the biosynthesis of these complex natural products... - The molecular basis of the expansive substrate specificity of the antibiotic resistance enzyme aminoglycoside acetyltransferase-6'-aminoglycoside phosphotransferase-2". The role of ASP-99 as an active site base important for acetyl transferDavid D Boehr
Antimicrobial Research Centre, Department of Biochemistry, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
J Biol Chem 278:12873-80. 2003..The prominent role of this residue in aminoglycoside modification can be exploited as an anchoring site for the development of compounds capable of reversing antibiotic resistance in vivo... - Functionally important amino acids in Saccharomyces cerevisiae aspartate kinaseDavid C Bareich
Department of Biochemistry, McMaster University, 1200 Main St, W, Hamilton, Ont, Canada L8N 3Z5
Biochem Biophys Res Commun 311:597-603. 2003..These results provide the first identification of amino acid residues crucial to the action of this important metabolic enzyme... - Crystal structure of homoserine transacetylase from Haemophilus influenzae reveals a new family of alpha/beta-hydrolasesI Ahmad Mirza
Department of Biochemistry, McGill University, Montreal, Quebec, Canada H3A 1A4
Biochemistry 44:15768-73. 2005..Furthermore, the properties of the tunnel provide a rationale for how homoserine transacetylase catalyzes a transferase reaction vs hydrolysis, despite extensive similarity in active site architecture to hydrolytic enzymes... - Crystal structure of StaL, a glycopeptide antibiotic sulfotransferase from Streptomyces toyocaensisRong Shi
Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6
J Biol Chem 282:13073-86. 2007.... - Characterization of an inducible vancomycin resistance system in Streptomyces coelicolor reveals a novel gene (vanK) required for drug resistanceHee Jeon Hong
Department of Molecular Microbiology, John Innes Centre, Colney, Norwich NR4 7UH, UK
Mol Microbiol 52:1107-21. 2004..Analysis of mutants defective in the vanRS and cseBC cell envelope signal transduction systems revealed significant cross-talk between the two pathways... - Synthesis and structure-activity relationships of truncated bisubstrate inhibitors of aminoglycoside 6'-N-acetyltransferasesFeng Gao
Department of Chemistry, McGill University, 801 Sherbrooke Street West, , , Canada
J Med Chem 49:5273-81. 2006..Moreover, one of the inhibitors is able to block aminoglycoside resistance in cells expressing this enzyme... - Structural basis for streptogramin B resistance in Staphylococcus aureus by virginiamycin B lyaseMagdalena Korczynska
Department of Biochemistry, McGill University, Montreal, QC, Canada H3A 4A2
Proc Natl Acad Sci U S A 104:10388-93. 2007....