Judith A West-Mays

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. pmc Positive influence of AP-2alpha transcription factor on cadherin gene expression and differentiation of the ocular surface
    Judith A West-Mays
    Department of Pathology and Molecular Medicine, McMaster University, Health Sciences Center, Hamilton, ON, Canada
    Differentiation 71:206-16. 2003
  2. pmc Development and use of the lens epithelial explant system to study lens differentiation and cataractogenesis
    Judith A West-Mays
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Prog Retin Eye Res 29:135-43. 2010
  3. pmc The keratocyte: corneal stromal cell with variable repair phenotypes
    Judith A West-Mays
    Department of Pathology and Molecular Medicine, McMaster University, HSC 1R10, Hamilton, Ont, Canada L8N3Z5
    Int J Biochem Cell Biol 38:1625-31. 2006
  4. pmc AP-2alpha knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis
    Erin A Bassett
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Hum Mol Genet 19:1791-804. 2010
  5. pmc Targeted deletion of AP-2alpha leads to disruption in corneal epithelial cell integrity and defects in the corneal stroma
    Dhruva J Dwivedi
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Invest Ophthalmol Vis Sci 46:3623-30. 2005
  6. doi request reprint Ocular gene transfer of active TGF-beta induces changes in anterior segment morphology and elevated IOP in rats
    Jennifer V Robertson
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Invest Ophthalmol Vis Sci 51:308-18. 2010
  7. ncbi request reprint Genetic analysis indicates that transcription factors AP-2alpha and Pax6 cooperate in the normal patterning and morphogenesis of the lens
    Leila F Makhani
    Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Mol Vis 13:1215-25. 2007
  8. pmc Temporal changes in MMP mRNA expression in the lens epithelium during anterior subcapsular cataract formation
    Zahra Nathu
    Department of Pathology and Molecular Medicine, McMaster University, Health Sciences Centre, Hamilton, ON, Canada
    Exp Eye Res 88:323-30. 2009
  9. pmc Activation of the hedgehog signaling pathway in the developing lens stimulates ectopic FoxE3 expression and disruption in fiber cell differentiation
    Christine L Kerr
    Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada
    Invest Ophthalmol Vis Sci 53:3316-30. 2012
  10. pmc Cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotype
    Giuseppe F Pontoriero
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Dev Dyn 237:602-17. 2008

Collaborators

Detail Information

Publications20

  1. pmc Positive influence of AP-2alpha transcription factor on cadherin gene expression and differentiation of the ocular surface
    Judith A West-Mays
    Department of Pathology and Molecular Medicine, McMaster University, Health Sciences Center, Hamilton, ON, Canada
    Differentiation 71:206-16. 2003
    ..Together, these findings demonstrate that AP-2alpha participates in regulating differentiation of the ocular surface through induction in cadherin expression...
  2. pmc Development and use of the lens epithelial explant system to study lens differentiation and cataractogenesis
    Judith A West-Mays
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Prog Retin Eye Res 29:135-43. 2010
    ....
  3. pmc The keratocyte: corneal stromal cell with variable repair phenotypes
    Judith A West-Mays
    Department of Pathology and Molecular Medicine, McMaster University, HSC 1R10, Hamilton, Ont, Canada L8N3Z5
    Int J Biochem Cell Biol 38:1625-31. 2006
    ..Finally, the recent identification of bone-marrow derived stem cells in the corneal stroma suggests a further complexity in the regulation of the keratocyte phenotype following injury...
  4. pmc AP-2alpha knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis
    Erin A Bassett
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Hum Mol Genet 19:1791-804. 2010
    ..In view of recent data showing that mutations in human TFAP2A result in similar eye defects, the current findings demonstrate that AP-2alpha KO mice provide a valuable model for human ocular disease...
  5. pmc Targeted deletion of AP-2alpha leads to disruption in corneal epithelial cell integrity and defects in the corneal stroma
    Dhruva J Dwivedi
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Invest Ophthalmol Vis Sci 46:3623-30. 2005
    ..The present study was undertaken to create a conditional knockout of AP-2alpha in the corneal epithelium...
  6. doi request reprint Ocular gene transfer of active TGF-beta induces changes in anterior segment morphology and elevated IOP in rats
    Jennifer V Robertson
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Invest Ophthalmol Vis Sci 51:308-18. 2010
    ..Gene transfer of TGF-beta can, therefore, be used to induce anatomic changes in the anterior segment in a rodent model that result in ocular hypertension...
  7. ncbi request reprint Genetic analysis indicates that transcription factors AP-2alpha and Pax6 cooperate in the normal patterning and morphogenesis of the lens
    Leila F Makhani
    Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Mol Vis 13:1215-25. 2007
    ..In this study we examined the overlapping expression patterns of Pax6 and AP-2alpha in the developing mouse lens and further investigated their potential cooperative roles through the creation of double heterozygote mice...
  8. pmc Temporal changes in MMP mRNA expression in the lens epithelium during anterior subcapsular cataract formation
    Zahra Nathu
    Department of Pathology and Molecular Medicine, McMaster University, Health Sciences Centre, Hamilton, ON, Canada
    Exp Eye Res 88:323-30. 2009
    ..Further experiments using FHL 124 cells show an induction in MMP-2 protein levels following treatment with recombinant MMP-9. Together these findings suggest an upstream role for MMP-9 in ASC formation...
  9. pmc Activation of the hedgehog signaling pathway in the developing lens stimulates ectopic FoxE3 expression and disruption in fiber cell differentiation
    Christine L Kerr
    Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada
    Invest Ophthalmol Vis Sci 53:3316-30. 2012
    ..Hedgehog signaling is implicated in eye development, and defects in hedgehog signaling components have been shown to result in defects of the retina, iris, and lens...
  10. pmc Cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotype
    Giuseppe F Pontoriero
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Dev Dyn 237:602-17. 2008
    ..wild-type littermates revealed differential expression of 415 mRNAs, including reduced expression of genes important for maintaining the lens epithelial cell phenotype, such as E-cadherin...
  11. pmc Conditional deletion of activating protein 2alpha (AP-2alpha) in the developing retina demonstrates non-cell-autonomous roles for AP-2alpha in optic cup development
    Erin A Bassett
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Mol Cell Biol 27:7497-510. 2007
    ..Additional expression analyses showed that multiple AP-2 proteins are present in the developing retina, which will be important to future studies...
  12. pmc Adenoviral gene transfer of bioactive TGFbeta1 to the rodent eye as a novel model for anterior subcapsular cataract
    Jennifer V Robertson
    Department of Pathology and Molecular Medicine and Centre for Gene Therapeutics, McMaster University, Hamilton, ON, Canada
    Mol Vis 13:457-69. 2007
    ..Establishment of this model will be important for further investigations of TGFbeta-induced signaling cascades in ASC...
  13. doi request reprint Corneal epithelial cell adhesion and growth on EGF-modified aminated PDMS
    Bettina J Klenkler
    Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada L8S 4L7
    J Biomed Mater Res A 93:1043-9. 2010
    ..The results provide initial evidence that binding of EGF may be used to improve the epithelialization of and the adhesion of the cells on a polymeric artificial cornea device...
  14. ncbi request reprint The role of Hsp70 and Hsp90 in TGF-beta-induced epithelial-to-mesenchymal transition in rat lens epithelial explants
    Alice Banh
    School of Optometry, University of Waterloo, Waterloo, ON, Canada
    Mol Vis 13:2248-62. 2007
    ..This study investigates the effects of heat shock treatment and the role of Hsp70 and Hsp90 on tranforming growth factor beta 2 (TGF-beta2)-induced epithelial-to-mesenchymal transition (EMT) in rat lens epithelial explants...
  15. ncbi request reprint Transient overexpression of TGF-{beta}1 induces epithelial mesenchymal transition in the rodent peritoneum
    Peter J Margetts
    Department of Medicine, McMaster University, Division of Nephrology, Street Joseph s Hospital, 50 Charl ton Avenue E, Hamilton, Ontario, Canada, L8P 4A6
    J Am Soc Nephrol 16:425-36. 2005
    ..This further supports the central role of TGF-beta1 in peritoneal fibrosis and provides an important model to study the sequence of events involved in TGF-beta1-induced EMT...
  16. pmc Overlapping expression patterns and redundant roles for AP-2 transcription factors in the developing mammalian retina
    Erin A Bassett
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Dev Dyn 241:814-29. 2012
    ..Although retina-specific deletion of Tcfap2a did not affect retinogenesis, two other family members, AP-2β and AP-2γ, showed expression patterns similar to AP-2α...
  17. pmc Co-operative roles for E-cadherin and N-cadherin during lens vesicle separation and lens epithelial cell survival
    Giuseppe F Pontoriero
    Department of Pathology and Molecular Medicine, McMaster University, ON, Canada
    Dev Biol 326:403-17. 2009
    ..These data suggest that the co-operative expression of both E- and N-cadherin during lens development is essential for normal cell sorting and subsequent lens vesicle separation...
  18. pmc Matrix metalloproteinase inhibitors suppress transforming growth factor-beta-induced subcapsular cataract formation
    Dhruva J Dwivedi
    Department of Pathology and Molecular Medicine, McMaster University, HSC 1R10, Hamilton, ON, Canada L8N3Z5
    Am J Pathol 168:69-79. 2006
    ..Together, these findings demonstrate that TGFbeta-induced E-cadherin shedding in the lens is mediated by MMPs and that suppression of this phenomenon might explain the mechanism by which MMPIs inhibit ASC plaque formation...
  19. pmc Altered expression of transforming growth factor beta 1 and matrix metalloproteinase-9 results in elevated intraocular pressure in mice
    Jennifer V Robertson
    Department of Pathology and Molecular Medicine, McMaster University Health Science Centre, Rm 1R10, 1200 Main St West Hamilton, ON, Canada
    Mol Vis 19:684-95. 2013
    ..We therefore sought to determine whether loss of MMP expression also altered TGFβ-induced changes in intraocular pressure (IOP)...
  20. pmc Nuclear translocation of myocardin-related transcription factor-A during transforming growth factor beta-induced epithelial to mesenchymal transition of lens epithelial cells
    Madhuja Gupta
    Department of Pathology and Molecular Medicine, McMaster University Health Science Centre, Rm 1R10, 1200 Main St West Hamilton, ON, L8N 3Z5, Canada
    Mol Vis 19:1017-28. 2013
    ..We further investigated the relationship between matrix metalloproteinase-2 and -9 (MMP-2/9) and MRTF in the EMT of LECs...