Elena F Verdu

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint Gliadin-dependent neuromuscular and epithelial secretory responses in gluten-sensitive HLA-DQ8 transgenic mice
    E F Verdu
    Intestinal Disease Research Program, McMaster University, HSC 3N5C, Hamilton, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 294:G217-25. 2008
  2. doi request reprint The role of luminal factors in the recovery of gastric function and behavioral changes after chronic Helicobacter pylori infection
    Elena F Verdu
    McMaster Univ HSC 3N49C, 1200 Main St West, Hamilton, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 295:G664-70. 2008
  3. pmc Effect of probiotics on gastrointestinal function: evidence from animal models
    Elena F Verdu
    Department of Medicine, McMaster University, Hamilton, Canada
    Therap Adv Gastroenterol 2:31-5. 2009
  4. doi request reprint Probiotics effects on gastrointestinal function: beyond the gut?
    E F Verdu
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Canada
    Neurogastroenterol Motil 21:477-80. 2009
  5. pmc Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice
    E F Verdu
    Intestinal Disease Research Program, McMaster University, 1200 Main S West, Hamilton, Ontario, Canada
    Gut 55:182-90. 2006
  6. ncbi request reprint Antidepressants attenuate increased susceptibility to colitis in a murine model of depression
    Ashwin K Varghese
    Intestinal Diseases Research Program, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 130:1743-53. 2006
  7. doi request reprint The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice
    Premysl Bercik
    The Farncombe Family Digestive Health Institute, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 141:599-609, 609.e1-3. 2011
  8. doi request reprint Reactivation of inflammatory bowel disease in a mouse model of depression
    Jean Eric Ghia
    Farncombe Family Digestive Health Research Institute, Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 136:2280-2288.e1-4. 2009
  9. doi request reprint Commensal and probiotic bacteria influence intestinal barrier function and susceptibility to colitis in Nod1-/-; Nod2-/- mice
    Jane M M Natividad
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Canada
    Inflamm Bowel Dis 18:1434-46. 2012
  10. ncbi request reprint Immune-mediated neural dysfunction in a murine model of chronic Helicobacter pylori infection
    Premysl Bercik
    Intestinal Diseases Research Programme, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 123:1205-15. 2002

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Gliadin-dependent neuromuscular and epithelial secretory responses in gluten-sensitive HLA-DQ8 transgenic mice
    E F Verdu
    Intestinal Disease Research Program, McMaster University, HSC 3N5C, Hamilton, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 294:G217-25. 2008
    ..The results provide a mechanism by which gluten could induce gut dysfunction in patients with a genetic predisposition but without fully evolved celiac disease...
  2. doi request reprint The role of luminal factors in the recovery of gastric function and behavioral changes after chronic Helicobacter pylori infection
    Elena F Verdu
    McMaster Univ HSC 3N49C, 1200 Main St West, Hamilton, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 295:G664-70. 2008
    ..These changes do not seem to occur in association with modulation of intestinal permeability...
  3. pmc Effect of probiotics on gastrointestinal function: evidence from animal models
    Elena F Verdu
    Department of Medicine, McMaster University, Hamilton, Canada
    Therap Adv Gastroenterol 2:31-5. 2009
    ..This article focuses on lessons learned from animal models of gut dysfunction...
  4. doi request reprint Probiotics effects on gastrointestinal function: beyond the gut?
    E F Verdu
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Canada
    Neurogastroenterol Motil 21:477-80. 2009
    ....
  5. pmc Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice
    E F Verdu
    Intestinal Disease Research Program, McMaster University, 1200 Main S West, Hamilton, Ontario, Canada
    Gut 55:182-90. 2006
    ..These symptoms fluctuate over time but the basis for this is unknown. Here we examine the impact of changes in gut flora and gut inflammatory cell activity on visceral sensitivity...
  6. ncbi request reprint Antidepressants attenuate increased susceptibility to colitis in a murine model of depression
    Ashwin K Varghese
    Intestinal Diseases Research Program, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 130:1743-53. 2006
    ..We also examined whether antidepressant therapy attenuates the increased susceptibility to colitis...
  7. doi request reprint The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice
    Premysl Bercik
    The Farncombe Family Digestive Health Institute, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 141:599-609, 609.e1-3. 2011
    ..We examined whether the intestinal microbiota affects behavior and brain biochemistry in mice...
  8. doi request reprint Reactivation of inflammatory bowel disease in a mouse model of depression
    Jean Eric Ghia
    Farncombe Family Digestive Health Research Institute, Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 136:2280-2288.e1-4. 2009
    ..We investigated whether the development of depression after the establishment of chronic inflammation reactivates an acute relapse of IBD and underlying pharmacologic mechanisms in mouse models...
  9. doi request reprint Commensal and probiotic bacteria influence intestinal barrier function and susceptibility to colitis in Nod1-/-; Nod2-/- mice
    Jane M M Natividad
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Canada
    Inflamm Bowel Dis 18:1434-46. 2012
    ..We investigated whether the intestinal microbiota and the probiotic strain Bifidobacterium breve NCC2950 affect intestinal barrier function and responses to intestinal injury in Nod1(-/-); Nod2(-/-) mice...
  10. ncbi request reprint Immune-mediated neural dysfunction in a murine model of chronic Helicobacter pylori infection
    Premysl Bercik
    Intestinal Diseases Research Programme, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 123:1205-15. 2002
    ..Neuromuscular changes producing dysmotility and hyperalgesia may underlie symptom generation in functional gastrointestinal disorders. We investigated whether chronic Helicobacter pylori-induced gastritis causes neuromuscular dysfunction...
  11. pmc Visceral pain perception is determined by the duration of colitis and associated neuropeptide expression in the mouse
    Monica Verma-Gandhu
    Intestinal Disease Research Programme, McMaster University, Health Sciences Bldg, Hamilton, ON, Canada
    Gut 56:358-64. 2007
    ..This suggests that the nature of the inflammatory infiltrate influences visceral perception...
  12. ncbi request reprint Lactobacillus paracasei normalizes muscle hypercontractility in a murine model of postinfective gut dysfunction
    Elena F Verdu
    McMaster University, 1200 Main Street West, HSC 3N5C, Hamilton, Ontario, Canada
    Gastroenterology 127:826-37. 2004
    ..We tested whether probiotics influence persistent muscle hypercontractility in mice after recovery from infection with Trichinella spiralis and analyzed the underlying mechanisms...
  13. ncbi request reprint CD4+ T-cell modulation of visceral nociception in mice
    Monica Verma-Gandhu
    Intestinal Disease Research Programme, McMaster University Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 130:1721-8. 2006
    ..We hypothesized that a component of the immune system exerts an antinociceptive influence, thus enabling the gut to function in the absence of undue pain or discomfort...
  14. ncbi request reprint Modulatory effects of estrogen in two murine models of experimental colitis
    Elena F Verdu
    Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Am J Physiol Gastrointest Liver Physiol 283:G27-36. 2002
    ..The net modulatory effect most likely reflects a combination of estrogen receptor-mediated effects and antioxidant activity and may explain, in part, conflicting results from clinical trials...
  15. ncbi request reprint Visceral hyperalgesia and intestinal dysmotility in a mouse model of postinfective gut dysfunction
    Premysl Bercik
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 127:179-87. 2004
    ..The present study determined whether gut dysfunction in this model involves motor and sensory changes reminiscent of changes found in patients with postinfective irritable bowel syndrome (PI-IBS) and investigated underlying mechanisms...
  16. pmc Increased bacterial translocation in gluten-sensitive mice is independent of small intestinal paracellular permeability defect
    Manuel A Silva
    Department of Medicine, Health Sciences Centre, Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada
    Dig Dis Sci 57:38-47. 2012
    ....
  17. doi request reprint Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice
    Premysl Bercik
    Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 139:2102-2112.e1. 2010
    ..Clinical and preclinical studies have associated gastrointestinal inflammation and infection with altered behavior. We investigated whether chronic gut inflammation alters behavior and brain biochemistry and examined underlying mechanisms...
  18. pmc Sensitization to gliadin induces moderate enteropathy and insulitis in nonobese diabetic-DQ8 mice
    Heather J Galipeau
    Farncombe Family Digestive Health Research Institute, McMaster University Medical Centre, Hamilton, Ontario L8N 3Z5, Canada
    J Immunol 187:4338-46. 2011
    ..This humanized murine model provides a mechanistic link to explain how the mucosal intolerance to a dietary protein can lead to insulitis in the presence of partial regulatory T cell deficiency...
  19. ncbi request reprint The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model
    Jean Eric Ghia
    Intestinal Diseases Research Programme, Health Science Center, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    Gastroenterology 131:1122-30. 2006
    ..The purpose of this study was to determine whether a similar vagus/macrophage axis modulates the inflammatory responses in the colon in mice...
  20. pmc Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism
    Emma Slack
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4L8, Canada
    Science 325:617-20. 2009
    ..Spontaneous hyper-activation of adaptive immunity against the intestinal microbiota, secondary to innate immune deficiency, may clarify the underlying mechanisms of inflammatory diseases where immune dysfunction is implicated...
  21. pmc Testing for gluten-related disorders in clinical practice: the role of serology in managing the spectrum of gluten sensitivity
    David Armstrong
    McMaster University, Hamilton, Ontario, Canada
    Can J Gastroenterol 25:193-7. 2011
    ..Studies are needed to determine the clinical utility of antigliadin serology in the diagnosis of gluten sensitivity...
  22. ncbi request reprint Is irritable bowel syndrome a low-grade inflammatory bowel disease?
    Premysl Bercik
    Intestinal Disease Research Program and Division of Gastroenterology, McMaster University, 1200 Main Street West, HSC 3N49C, Hamilton, Ontario L8N 3Z5, Canada
    Gastroenterol Clin North Am 34:235-45, vi-vii. 2005
    ..This article examines these relation-ships using immune activation and inflammation as a common pathogenic process to IBD and a subset of IBS patients...
  23. doi request reprint Role of gut-brain axis in persistent abnormal feeding behavior in mice following eradication of Helicobacter pylori infection
    Premysl Bercik
    Intestinal Diseases Research Program, McMaster Univ, MUMC 4W8, Hamilton, Ontario L8N 3Z5
    Am J Physiol Regul Integr Comp Physiol 296:R587-94. 2009
    ..pylori eradication and is accompanied by increased TNF-alpha in the brain. The results support a role for altered gut-brain pathways in the maintenance of postinfective gut dysfunction...
  24. doi request reprint The putative role of the intestinal microbiota in the irritable bowel syndrome
    S M Collins
    The Farncombe Digestive Health Research Institute, The Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Dig Liver Dis 41:850-3. 2009
    ..This hypothesis states that dysbiosis exists in at least a subset of IBS patients, as a result of infection, dietary change or drugs and contributes to gut inflammatory and functional change in addition to psychiatric co-morbidity...
  25. ncbi request reprint Critical role of MCP-1 in the pathogenesis of experimental colitis in the context of immune and enterochromaffin cells
    W I Khan
    Intestinal Disease Research Program, Department of Medicine, McMaster University, 1200 Main St West, Hamilton, ON, Canada L8N 3Z5
    Am J Physiol Gastrointest Liver Physiol 291:G803-11. 2006
    ..These results provide evidence for a critical role of MCP-1 in the development of colonic inflammation in this model in the context of immune and enteric endocrine cells...
  26. ncbi request reprint Irritable bowel syndrome and probiotics: from rationale to clinical use
    Elena F Verdu
    Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario, Canada
    Curr Opin Gastroenterol 21:697-701. 2005
    ..An understanding that probiotics are heterogeneous, with multiple targets and mechanisms of action, is fundamental to the development of clinical trials...
  27. pmc Host responses to intestinal microbial antigens in gluten-sensitive mice
    Jane M Natividad
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Canada
    PLoS ONE 4:e6472. 2009
    ..The aim of this study was to investigate whether intestinal barrier dysfunction induced by indomethacin treatment affects the host response to intestinal microbiota in gluten-sensitized HLA-DQ8/HCD4 mice...
  28. pmc Interleukin-15 and NK1.1+ cells provide innate protection against acute Salmonella enterica serovar Typhimurium infection in the gut and in systemic tissues
    Ali A Ashkar
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Infect Immun 77:214-22. 2009
    ..1(+) cells correlated with a localized disruption of IL-17 in the colon. These data suggest a relationship between the gut ecosystem and the innate mucosal immune system, which may be linked via IL-15 and NK1.1(+) cells...
  29. ncbi request reprint Microbial-gut interactions in health and disease. Irritable bowel syndrome
    Elena F Verdu
    Intestinal Research Programme, McMaster University, Hamilton, Ont, Canada
    Best Pract Res Clin Gastroenterol 18:315-21. 2004
    ..This chapter concentrates on the experimental evidence for a role of intestinal microbiota and the potential therapeutic value of probiotics in functional diseases such as irritable bowel syndrome...
  30. pmc Between celiac disease and irritable bowel syndrome: the "no man's land" of gluten sensitivity
    Elena F Verdu
    Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Gastroenterol 104:1587-94. 2009
    ..A better understanding of how gluten can cause symptoms in sensitive individuals will illuminate the interaction between host genotype, diet, and intestinal microbiota in generating one of the most common GI conditions...
  31. pmc Helminth antigen-based strategy to ameliorate inflammation in an experimental model of colitis
    Y Motomura
    Intestinal Diseases Research Program, Department of Pathology, McMaster University, Ontario, Canada
    Clin Exp Immunol 155:88-95. 2009
    ..These results clearly show a beneficial role of local treatment with helminth antigens for experimental colitis and prompt consideration of helminth antigen-based therapy for IBD instead of infection with live parasites...
  32. pmc Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein 1
    Y Motomura
    Intestinal Diseases Research Programme, McMaster University, Hamilton, Ontario, Canada
    Gut 55:662-70. 2006
    ..We investigated the fibrotic potential of MCP-1 in the gut by overexpressing this chemokine in the mouse colorectal wall...
  33. doi request reprint NK cells require type I IFN receptor for antiviral responses during genital HSV-2 infection
    Navkiran Gill
    Center for Gene Therapeutics and Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Cell Immunol 269:29-37. 2011
    ..Our data clearly suggest that type I IFN receptor signalling is essential for NK cell activation in response to genital HSV-2 infection, and propose that NK cell activation by IL-15 may involve type I IFNs...
  34. pmc Hydrogen sulfide and resolution of acute inflammation: A comparative study utilizing a novel fluorescent probe
    Neil Dufton
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Sci Rep 2:499. 2012
    ..Our report offers an insight into the profile of hydrogen sulfide synthesis during inflammation and highlight opportunities raised by the development of novel fluorescent hydrogen sulfide probes...
  35. doi request reprint Modulation of intestinal barrier by intestinal microbiota: Pathological and therapeutic implications
    Jane M M Natividad
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Canada
    Pharmacol Res 69:42-51. 2013
    ..A better understanding of the role of the intestinal microbiota in maintaining a functional intestinal barrier may help develop targeted strategies to prevent and treat disease...
  36. doi request reprint Chronic gastrointestinal consequences of acute infectious diarrhea: evolving concepts in epidemiology and pathogenesis
    Elena F Verdu
    Department of Medicine, Farncombe Family Digestive Health Institute, McMaster University, Hamilton, Ontario, Canada
    Am J Gastroenterol 107:981-9. 2012
    ....
  37. pmc Clinical onset of celiac disease after an episode of Campylobacter jejuni enteritis
    E F Verdu
    Intestinal Disease Research Program, Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Can J Gastroenterol 21:453-5. 2007
    ..The present case findings suggest that CD should be considered in the differential diagnosis of persistent IBS-like symptoms after an episode of infectious gastroenteritis...