Brian W Timmons

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint Paediatric exercise immunology: health and clinical applications
    Brian W Timmons
    Department of Paediatrics, McMaster University, Hamilton, ON, Canada
    Exerc Immunol Rev 11:108-44. 2005
  2. ncbi request reprint Puberty effects on NK cell responses to exercise and carbohydrate intake in boys
    Brian W Timmons
    Children s Exercise and Nutrition Centre, McMaster University, Hamilton, Ontario, Canada
    Med Sci Sports Exerc 38:864-74. 2006
  3. ncbi request reprint Immune responses to strenuous exercise and carbohydrate intake in boys and men
    Brian W Timmons
    Children s Exercise and Nutrition Centre, Chedoke Hospital, Evel Bldg 4 floor, Sanatorium Road, Hamilton, Ontario, Canada L8N 3Z5
    Pediatr Res 56:227-34. 2004
  4. ncbi request reprint Human natural killer cell subsets and acute exercise: a brief review
    Brian W Timmons
    Children s Exercise and Nutrition Centre, McMaster University
    Exerc Immunol Rev 14:8-23. 2008
  5. pmc Physical activity and sedentary behavior during the early years in Canada: a cross-sectional study
    Rachel C Colley
    Health Analysis Division, Statistics Canada, Ottawa, Canada
    Int J Behav Nutr Phys Act 10:54. 2013
  6. doi request reprint Systematic review of physical activity and health in the early years (aged 0-4 years)
    Brian W Timmons
    Department of Pediatrics, McMaster University, Hamilton, ON L8S 4K1, Canada
    Appl Physiol Nutr Metab 37:773-92. 2012
  7. pmc The health outcomes and physical activity in preschoolers (HOPP) study: rationale and design
    Brian W Timmons
    Child Health and Exercise Medicine Program, Department of Pediatrics, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada
    BMC Public Health 12:284. 2012
  8. ncbi request reprint Physical activity for preschool children--how much and how?
    Brian W Timmons
    Children s Exercise and Nutrition Centre, McMaster University, Hamilton, Ontario, Canada
    Can J Public Health 98:S122-34. 2007
  9. ncbi request reprint Lymphocyte expression of CD95 at rest and in response to acute exercise in healthy children and adolescents
    Brian W Timmons
    Children s Exercise and Nutrition Centre, Department of Pediatrics, McMaster University, Hamilton, ON, Canada L8N 3Z5
    Brain Behav Immun 21:442-9. 2007
  10. doi request reprint A pediatric perspective on inflammation and oxidative stress in response to exercise
    Brian W Timmons
    Children s Exercise and Nutrition Centre, McMaster University, Hamilton, ON, Canada
    Appl Physiol Nutr Metab 33:411-9. 2008

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Paediatric exercise immunology: health and clinical applications
    Brian W Timmons
    Department of Paediatrics, McMaster University, Hamilton, ON, Canada
    Exerc Immunol Rev 11:108-44. 2005
    ..Given the linkage between childhood health and adult disease, paediatric exercise immunology represents a fruitful area for future study...
  2. ncbi request reprint Puberty effects on NK cell responses to exercise and carbohydrate intake in boys
    Brian W Timmons
    Children s Exercise and Nutrition Centre, McMaster University, Hamilton, Ontario, Canada
    Med Sci Sports Exerc 38:864-74. 2006
    ..Previous research has demonstrated that younger versus older animals and humans experience smaller perturbations in natural killer (NK) cells in response to physiological stress...
  3. ncbi request reprint Immune responses to strenuous exercise and carbohydrate intake in boys and men
    Brian W Timmons
    Children s Exercise and Nutrition Centre, Chedoke Hospital, Evel Bldg 4 floor, Sanatorium Road, Hamilton, Ontario, Canada L8N 3Z5
    Pediatr Res 56:227-34. 2004
    ..CHO had no effect on TNF-alpha or IL-6 in either group. Our results indicate a distinct pattern of the immune response to exercise and CHO intake in boys, compared with men...
  4. ncbi request reprint Human natural killer cell subsets and acute exercise: a brief review
    Brian W Timmons
    Children s Exercise and Nutrition Centre, McMaster University
    Exerc Immunol Rev 14:8-23. 2008
    ..g., multiple sclerosis) as an adjunct therapy to mobilize the CD56(bright) subset. Further investigation into the biology of NK cell subsets and exercise should prove to be a fruitful area for years to come...
  5. pmc Physical activity and sedentary behavior during the early years in Canada: a cross-sectional study
    Rachel C Colley
    Health Analysis Division, Statistics Canada, Ottawa, Canada
    Int J Behav Nutr Phys Act 10:54. 2013
    ..This study presents data on the physical activity and sedentary behaviors of Canadian children aged 3-5 years...
  6. doi request reprint Systematic review of physical activity and health in the early years (aged 0-4 years)
    Brian W Timmons
    Department of Pediatrics, McMaster University, Hamilton, ON L8S 4K1, Canada
    Appl Physiol Nutr Metab 37:773-92. 2012
    ..There was no serious inconsistency in any of the studies reviewed. This evidence can help to inform public health guidelines. (PROSPERO registration: CRD42011001243)...
  7. pmc The health outcomes and physical activity in preschoolers (HOPP) study: rationale and design
    Brian W Timmons
    Child Health and Exercise Medicine Program, Department of Pediatrics, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada
    BMC Public Health 12:284. 2012
    ..The goal of the Health Outcomes and Physical activity in Preschoolers (HOPP) study is to describe how the prevalence and patterns of physical activity in preschoolers are associated with indices of health...
  8. ncbi request reprint Physical activity for preschool children--how much and how?
    Brian W Timmons
    Children s Exercise and Nutrition Centre, McMaster University, Hamilton, Ontario, Canada
    Can J Public Health 98:S122-34. 2007
    ..g., family, child-care, and socio-economic status). We provide recommendations for physical activity based on the best available evidence, and identify future research needs...
  9. ncbi request reprint Lymphocyte expression of CD95 at rest and in response to acute exercise in healthy children and adolescents
    Brian W Timmons
    Children s Exercise and Nutrition Centre, Department of Pediatrics, McMaster University, Hamilton, ON, Canada L8N 3Z5
    Brain Behav Immun 21:442-9. 2007
    ..We conclude that lymphocyte expression of CD95 is influenced by acute exercise in healthy children and adolescents. Exercise-induced alterations in CD95 expression may have clinical implications for some pediatric conditions...
  10. doi request reprint A pediatric perspective on inflammation and oxidative stress in response to exercise
    Brian W Timmons
    Children s Exercise and Nutrition Centre, McMaster University, Hamilton, ON, Canada
    Appl Physiol Nutr Metab 33:411-9. 2008
    ..This understanding will be particularly relevant for childhood diseases that restrict growth...
  11. doi request reprint Two methods for determining plasma IL-6 in humans at rest and following exercise
    Brian W Timmons
    Children s Exercise and Nutrition Centre, McMaster University, Chedoke Hospital, Evel Bldg, Sanatorium Road, Hamilton, ON, L8N 3Z5, Canada
    Eur J Appl Physiol 105:13-8. 2009
    ..0001), but exhibited poor agreement (mean bias +/- 1SD = -1.4 +/- 2.1 pg/mL). The CBA provided concordant IL-6 concentrations at rest, when detected, but underestimated exercise-induced increases in IL-6 versus the ELISA method...
  12. doi request reprint [Physical activity in children of preschool age - amount and method?]
    Brian W Timmons
    Children s Exercise and Nutrition Centre, Université McMaster, Evel Building, 4th Floor, Sanatorium Road, Hamilton, ON L8N 3Z5, Canada
    Appl Physiol Nutr Metab 32:S136-49. 2007
    ..g., family, child-care, and socio-economic status). We provide recommendations for physical activity based on the best available evidence, and identify future research needs...
  13. ncbi request reprint Evidence of sex-based differences in natural killer cell responses to exercise and carbohydrate intake in children
    Brian W Timmons
    Children s Exercise and Nutrition Centre, Departments of Pediatrics, McMaster University, Hamilton, ON, Canada
    Eur J Appl Physiol 101:233-40. 2007
    ..We conclude that even in young children sex-based differences exist in the NK cell response to exercise and CHO intake...
  14. ncbi request reprint Sex-based effects on the distribution of NK cell subsets in response to exercise and carbohydrate intake in adolescents
    Brian W Timmons
    Children s Exercise and Nutritional Centre, McMaster University Medical Center, Hamilton, Ontario, Canada L8N 3Z5
    J Appl Physiol 100:1513-9. 2006
    ..These results demonstrate sex-based differences in the distribution of NK cell subsets and activation status in response to exercise, but not CHO intake, and further support the need to control for sex in exercise immunology studies...
  15. ncbi request reprint Influence of age and pubertal status on substrate utilization during exercise with and without carbohydrate intake in healthy boys
    Brian W Timmons
    Children s Exercise and Nutrition Centre, Chedoke Hospital, McMaster University, Hamilton, Ontario, Canada
    Appl Physiol Nutr Metab 32:416-25. 2007
    ..51, p=0.005, n=29). It was concluded that reliance on CHOexo during exercise is particularly sensitive to pubertal status, with the highest oxidation rates observed in pre- and early-pubertal boys, independent of chronological age...
  16. doi request reprint Canadian Sedentary Behaviour Guidelines for the Early Years (aged 0-4 years)
    Mark S Tremblay
    University of Ottawa, Ottawa, ON, Canada
    Appl Physiol Nutr Metab 37:370-91. 2012
    ..For those under 2 years, screen time (e.g., TV, computer, electronic games) is not recommended. For children 2-4 years, screen time should be limited to under 1 h per day; less is better...
  17. ncbi request reprint Step count targets corresponding to new physical activity guidelines for the early years
    Leigh Gabel
    Child Health and Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    Med Sci Sports Exerc 45:314-8. 2013
    ..Step count targets corresponding to these recommendations will help practitioners and researchers monitor physical activity...
  18. ncbi request reprint Reliability of fitness measures in 3- to 5-year-old children
    Thanh Nguyen
    Children s Exercise and Nutrition Centre, Chedoke Hospital, McMaster University, Hamilton, Ontario, Canada
    Pediatr Exerc Sci 23:250-60. 2011
    ..91, CV = 3.7%). Reliability for HR at submaximal exercise (ICC = 0.28, CV = 18.8%) and HR recovery (ICC = 0.42, CV = 14.0%) was not as strong. These findings should assist in determining appropriate fitness tests for preschoolers...
  19. doi request reprint Carbohydrate intake reduces fat oxidation during exercise in obese boys
    Lisa Chu
    Children s Exercise and Nutrition Centre, McMaster University, Children s Hospital, Chedoke Hospital, Evel Bldg, Room 469, Sanatorium Road, P O Box 2000, Hamilton, ON, L8N 3Z5, Canada
    Eur J Appl Physiol 111:3135-41. 2011
    ..2 ± 6.1 mg × kg FFM(-1) × min(-1) during CARB and CONT, respectively (p = 0.06). In CARB, CHO(exo) oxidation contributed to 23.3 ± 4.2% of total EE. CHO intake markedly suppresses fat oxidation during exercise in obese boys...
  20. doi request reprint Canadian Physical Activity Guidelines for the Early Years (aged 0-4 years)
    Mark S Tremblay
    University of Ottawa, Ottawa, ON, Canada
    Appl Physiol Nutr Metab 37:345-69. 2012
    ..More daily physical activity provides greater benefits...
  21. doi request reprint Vascular and autonomic function in preschool-aged children with congenital heart disease
    Katharine D Currie
    Department of Kinesiology Child Health and Exercise Medicine Program, McMaster Children s Hospital, Hamilton, ON, Canada
    Congenit Heart Dis 7:289-97. 2012
    ..To compare indices of vascular health and heart rate variability in preschool-aged children with repaired congenital heart disease (CHD) including tetralogy of Fallot (n = 6) and coarctation of the aorta (n = 6)...
  22. doi request reprint Short-term muscle power and speed in preschoolers exhibit stronger tracking than physical activity
    Leigh Gabel
    McMaster University, Hamilton, ON L8N 3Z5, Canada
    Appl Physiol Nutr Metab 36:939-45. 2011
    ..82, p = 0.0001; ĸ = 0.47). Moderate-to-vigorous physical activity increased in this sample of boys and girls during the preschool years, and short-term muscle power and speed exhibited stronger tracking than physical activity...
  23. ncbi request reprint Reduced fat oxidation rates during submaximal exercise in adolescents with Crohn's disease
    Thanh Nguyen
    Child Health and Exercise Medicine Program, McMaster University, Hamilton, Ontario, Canada Department of Rehabilitation, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands McMaster Children s Hospital, Hamilton, Ontario, Canada Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada and University Medical Center Utrecht, Utrecht, The Netherlands
    Inflamm Bowel Dis 19:2659-65. 2013
    ..The aim of this study was to determine whether substrate utilization and bioavailability during exercise are altered in children with CD compared with controls...
  24. ncbi request reprint Influence of pubertal stage on local sweating patterns of girls exercising in the heat
    Boguslaw Wilk
    Children s Exercise and Nutrition Centre, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    Pediatr Exerc Sci 25:212-20. 2013
    ..Sweat drop area was lower in T1 vs T3 and in T1 vs T4, T2 vs T4 and T3 vs T4. The proportion of skin covered by sweat was lower in T1 vs T4. Sweating patterns of girls exercising in the heat are influenced by pubertal stage...
  25. ncbi request reprint Immunological changes in response to exercise: influence of age, puberty, and gender
    Brian W Timmons
    Children s Exercise and Nutrition Centre, McMaster University, Hamilton, Ontario, Canada
    Med Sci Sports Exerc 38:293-304. 2006
    ..This study tested the hypothesis that exercise-induced perturbation and recovery of the immune system would vary with age, puberty, and gender in healthy children and adolescents...
  26. doi request reprint Reduced fat oxidation rates during submaximal exercise in boys with cystic fibrosis
    Thanh Nguyen
    Child Health and Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, ON, Canada
    J Cyst Fibros 13:92-8. 2014
    ..Exercise is a viable form of therapy for children with cystic fibrosis (CF). Understanding the energy sources used during exercise would aid CF patients in obtaining proper nutrition in order to sustain an active lifestyle...
  27. pmc Chemokine (C-C motif) Ligand 2 is a potential biomarker of inflammation & physical fitness in obese children: a cross-sectional study
    M Constantine Samaan
    Division of Pediatric Endocrinology, Department of Pediatrics, McMaster Children s Hospital, McMaster University, 1280 Main Street West, HSC 3A57, Hamilton, Ontario L8S 4K1, Canada
    BMC Pediatr 13:47. 2013
    ..This study tested the hypotheses that CCL2 levels are higher in obese children when compared to lean controls, and that fitness modulates CCL2 levels allowing its use as a biomarker of fitness...
  28. doi request reprint Voluntary fluid intake, hydration status, and aerobic performance of adolescent athletes in the heat
    Boguslaw Wilk
    Children s Exercise and Nutrition Centre, McMaster University, Hamilton, ON L8N 3Z5, Canada
    Appl Physiol Nutr Metab 35:834-41. 2010
    ....
  29. ncbi request reprint No effect of short-term 17beta-estradiol supplementation in healthy men on systemic inflammatory responses to exercise
    Brian W Timmons
    Children s Exercise and Nutrition Center, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    Am J Physiol Regul Integr Comp Physiol 291:R285-90. 2006
    ..Future studies should investigate 17beta-estradiol effects on IL-6 production and neutrophil infiltration within skeletal muscle during and after exercise...
  30. ncbi request reprint Influence of gender, menstrual phase, and oral contraceptive use on immunological changes in response to prolonged cycling
    Brian W Timmons
    Children s Exercise and Nutrition Centre, McMaster Univ, Hamilton, Ontario, Canada
    J Appl Physiol 99:979-85. 2005
    ..Cortisol changes with exercise were not different between groups or MP. These results highlight the necessity to control for gender, and in particular OC use, when designing studies evaluating exercise and immunology...
  31. ncbi request reprint RPE during prolonged cycling with and without carbohydrate ingestion in boys and men
    Brian W Timmons
    Children s Exercise and Nutrition Centre, McMaster University, Hamilton, Ontario, Canada
    Med Sci Sports Exerc 35:1901-7. 2003
    ..To examine the effect of prolonged cycling on ratings of perceived exertion (RPE) in boys and men and whether carbohydrate (CHO) ingestion would lower RPE during exercise...
  32. ncbi request reprint Energy substrate utilization during prolonged exercise with and without carbohydrate intake in preadolescent and adolescent girls
    Brian W Timmons
    Children s Exercise and Nutrition Centre, McMaster University, Hamilton, Ontario, Canada
    J Appl Physiol 103:995-1000. 2007
    ..Our results also point to potential sex-related differences in energy substrate utilization even during childhood...
  33. ncbi request reprint Oxidation rate of exogenous carbohydrate during exercise is higher in boys than in men
    Brian W Timmons
    Children s Exercise and Nutrition Centre, McMaster University, Hamilton L8N 3Z5, Canada M3J 1P3
    J Appl Physiol 94:278-84. 2003
    ..The greater reliance on CHO(exo) in boys may be important in preserving endogenous fuels and may be related to pubertal status...
  34. doi request reprint Inflammatory and growth factor response to continuous and intermittent exercise in youth with cystic fibrosis
    Thanh Nguyen
    Child Health and Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, ON, Canada
    J Cyst Fibros 11:108-18. 2012
    ..Therefore, investigating which type of exercise can elicit an anabolic response with minimal inflammation is of clinical value...
  35. ncbi request reprint Optimizing the Wingate Anaerobic Cycling Test for youth with juvenile idiopathic arthritis
    Joyce Obeid
    Children Health and Exercise Medicine Program, Chedoke Hospital, Hamilton, Ontario, Canada
    Pediatr Exerc Sci 23:303-10. 2011
    ..5 ± 2.6 vs. 10.8 ± 1.0 W/kg, respectively; p = .07). No differences were observed for MP (standard: 6.2 ± 0.9 vs. optimized: 6.2 ± 1.1 W/kg; p = .9). Optimization of the WAnT tended to increase PP by 10-28% in youth with JIA...
  36. doi request reprint Effects of recovery method after exercise on performance, immune changes, and psychological outcomes
    Douglas L Stacey
    Fowler Kennedy Sports Medicine Clinic, London, ON, Canada
    J Orthop Sports Phys Ther 40:656-65. 2010
    ..Randomized controlled trial using a repeated-measures design...
  37. doi request reprint Physical activity in Ontario preschoolers: prevalence and measurement issues
    Joyce Obeid
    Child Health and Exercise Program, McMaster University and McMaster Children s Hospital, Chedoke Site, Evel Building, Room 469, 555 Sanatorium Road, Hamilton, ON L8N 3Z5, Canada
    Appl Physiol Nutr Metab 36:291-7. 2011
    ..Our data highlight important methodological considerations when measuring physical activity in preschoolers and the need for preschool-specific physical activity guidelines for Canadian children...
  38. ncbi request reprint Correlates of mucosal immunity and upper respiratory tract infections in girls
    Lauren Corbett
    Faculty of Applied Health Sciences, Department of Psychology, Brock University, Ontario, Canada
    J Pediatr Endocrinol Metab 23:579-87. 2010
    ..41; p < 0.05) with the testosterone to cortisol ratio. These results suggest that mucosal immunity increases with pubertal maturation, while higher cortisol is associated with lower mucosal immunity in adolescents...
  39. doi request reprint Mild to moderate hypohydration reduces boys' high-intensity cycling performance in the heat
    Boguslaw Wilk
    Child Health and Exercise Medicine Program, Room 3N27G, McMaster University, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada
    Eur J Appl Physiol 114:707-13. 2014
    ..To evaluate the effect of 1 and 2 % hypohydration on high-intensity cycling performance of 10- to 12-year-old boys in the heat...
  40. pmc Arterial structure and function in ambulatory adolescents with cerebral palsy are not different from healthy controls
    Audra A Martin
    Department of Kinesiology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1
    Int J Pediatr 2012:168209. 2012
    ..Arterial health of ambulatory youth with CP is not different from a control group despite lower vigorous PA levels. Similar studies need to examine individuals with more pronounced mobility limitations (GMFCS level III-V)...
  41. pmc Accelerometry: a feasible method to quantify physical activity in ambulatory and nonambulatory adolescents with cerebral palsy
    Jan Willem Gorter
    CanChild Centre for Childhood Disability Research, McMaster University, 1400 Main Street West, IAHS Building, Room 408, Hamilton, ON, Canada L8S 1C7
    Int J Pediatr 2012:329284. 2012
    ..05). Conclusion(s). The results support the use of the accelerometer as a feasible and useful measure of activity in ambulatory and nonambulatory adolescents with CP...
  42. doi request reprint Noninvasive measures of vascular health are reliable in preschool-aged children
    Katharine D Currie
    Department of Kinesiology, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada
    Appl Physiol Nutr Metab 35:512-7. 2010
    ..63) is likely attributable to the variability of blood pressure measurements. This study confirms that vascular measurements demonstrate substantial reliability in preschool-aged children as young as 2 years...
  43. doi request reprint Effect of dietary protein content during recovery from high-intensity cycling on subsequent performance and markers of stress, inflammation, and muscle damage in well-trained men
    David S Rowlands
    Institute of Food, Nutrition and Human Health, Massey University, New Zealand
    Appl Physiol Nutr Metab 33:39-51. 2008
    ..kg FFM(-1)) in the control condition. A nutritive effect of post-exercise protein content was not discernible short term (15 h), but a delayed performance benefit (60 h) was observed following protein-enriched high-carbohydrate ingestion...
  44. ncbi request reprint Exercise and the cytokine balance: a paediatric perspective
    Brian W Timmons
    J Sports Sci 24:1-2. 2006
  45. doi request reprint Fat oxidation rate and the exercise intensity that elicits maximal fat oxidation decreases with pubertal status in young male subjects
    M C Riddell
    School of Kinesiology and Health Science, Faculty of Health, York University, 4700 Keele St, Toronto, ON, Canada M3J 1P3
    J Appl Physiol (1985) 105:742-8. 2008
    ..06). We conclude that, compared with men, prepubertal boys have higher relative FOR throughout a wide range of exercise intensities and that FOR drops as boys develop through puberty...