Lehana Thabane

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. pmc A systematic scoping review of adherence to reporting guidelines in health care literature
    Zainab Samaan
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, Canada Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada Population Genomics Program, McMaster University, Hamilton, ON, Canada
    J Multidiscip Healthc 6:169-88. 2013
  2. pmc Mentoring in biostatistics: some suggestions for reform
    Adefowope Odueyungbo
    Department of Biostatistics, Vertex Pharmaceuticals, Cambridge, MA
    J Multidiscip Healthc 5:265-72. 2012
  3. pmc Measuring the degree of integration for an integrated service network
    Chenglin Ye
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton ON, L8S 4L8 Canada
    Int J Integr Care 12:e137. 2012
  4. pmc Assessing the effectiveness of 'pulse radiofrequency treatment of dorsal root ganglion' in patients with chronic lumbar radicular pain: study protocol for a randomized control trial
    Harsha Shanthanna
    Department of Anesthesia and Pain Medicine D 149, St Joseph s Hospital, 50 Charlton Avenue East Hamilton, Ontario, L8N 4A6, Canada
    Trials 13:52. 2012
  5. pmc Male involvement in prevention programs of mother to child transmission of HIV: a systematic review to identify barriers and facilitators
    Frederick Morfaw
    Department of Obstetrics and Gynaecology, Faculty of Medicines and Biomedical Sciences, University of Yaounde 1, PO Box 1364, Yaounde, Cameroon
    Syst Rev 2:5. 2013
  6. pmc Strategies to enhance venous thromboprophylaxis in hospitalized medical patients (SENTRY): a pilot cluster randomized trial
    Menaka Pai
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Implement Sci 8:1. 2013
  7. pmc Chemokine (C-C motif) Ligand 2 is a potential biomarker of inflammation & physical fitness in obese children: a cross-sectional study
    M Constantine Samaan
    Division of Pediatric Endocrinology, Department of Pediatrics, McMaster Children s Hospital, McMaster University, 1280 Main Street West, HSC 3A57, Hamilton, Ontario L8S 4K1, Canada
    BMC Pediatr 13:47. 2013
  8. pmc Factors affecting pediatric isotonic fluid resuscitation efficiency: a randomized controlled trial evaluating the impact of syringe size
    Greg Harvey
    Department of Pediatrics, McMaster Children s Hospital, McMaster University, Hamilton, ON, Canada
    BMC Emerg Med 13:14. 2013
  9. pmc Do children with central venous line (CVL) dysfunction have increased risk of symptomatic thromboembolism compared to those without CVL-dysfunction, while on cancer therapy?
    Jacqueline Halton
    The Children s Hospital of Eastern Ontario CHEO, Ottawa, ON, Canada
    BMC Cancer 12:314. 2012
  10. pmc Trends and determining factors associated with adherence to antiretroviral therapy (ART) in Cameroon: a systematic review and analysis of the CAMPS trial
    Lawrence Mbuagbaw
    Centre for Development of Best Practices in Health CDBPH, Yaounde Central Hospital, Avenue Henri Dunant, Messa, PO Box 87, Yaounde, Cameroon
    AIDS Res Ther 9:37. 2012

Detail Information

Publications167 found, 100 shown here

  1. pmc A systematic scoping review of adherence to reporting guidelines in health care literature
    Zainab Samaan
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, Canada Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada Population Genomics Program, McMaster University, Hamilton, ON, Canada
    J Multidiscip Healthc 6:169-88. 2013
    ....
  2. pmc Mentoring in biostatistics: some suggestions for reform
    Adefowope Odueyungbo
    Department of Biostatistics, Vertex Pharmaceuticals, Cambridge, MA
    J Multidiscip Healthc 5:265-72. 2012
    ..Our suggestions also cover what mentors and mentees can do to facilitate a successful mentoring relationship...
  3. pmc Measuring the degree of integration for an integrated service network
    Chenglin Ye
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton ON, L8S 4L8 Canada
    Int J Integr Care 12:e137. 2012
    ..We used the average score to measure the global network integration and examined the sensitivity of the global score...
  4. pmc Assessing the effectiveness of 'pulse radiofrequency treatment of dorsal root ganglion' in patients with chronic lumbar radicular pain: study protocol for a randomized control trial
    Harsha Shanthanna
    Department of Anesthesia and Pain Medicine D 149, St Joseph s Hospital, 50 Charlton Avenue East Hamilton, Ontario, L8N 4A6, Canada
    Trials 13:52. 2012
    ..Our primary objective is to study the feasibility of a larger trial in terms of recruitment and methodology. Secondary objectives are to compare the treatment effects and side effects...
  5. pmc Male involvement in prevention programs of mother to child transmission of HIV: a systematic review to identify barriers and facilitators
    Frederick Morfaw
    Department of Obstetrics and Gynaecology, Faculty of Medicines and Biomedical Sciences, University of Yaounde 1, PO Box 1364, Yaounde, Cameroon
    Syst Rev 2:5. 2013
    ..This paper summarizes the barriers and facilitators of male involvement in prevention programs of mother-to-child-transmission of HIV...
  6. pmc Strategies to enhance venous thromboprophylaxis in hospitalized medical patients (SENTRY): a pilot cluster randomized trial
    Menaka Pai
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Implement Sci 8:1. 2013
    ..Knowledge-translation strategies are needed to bridge this gap...
  7. pmc Chemokine (C-C motif) Ligand 2 is a potential biomarker of inflammation & physical fitness in obese children: a cross-sectional study
    M Constantine Samaan
    Division of Pediatric Endocrinology, Department of Pediatrics, McMaster Children s Hospital, McMaster University, 1280 Main Street West, HSC 3A57, Hamilton, Ontario L8S 4K1, Canada
    BMC Pediatr 13:47. 2013
    ..This study tested the hypotheses that CCL2 levels are higher in obese children when compared to lean controls, and that fitness modulates CCL2 levels allowing its use as a biomarker of fitness...
  8. pmc Factors affecting pediatric isotonic fluid resuscitation efficiency: a randomized controlled trial evaluating the impact of syringe size
    Greg Harvey
    Department of Pediatrics, McMaster Children s Hospital, McMaster University, Hamilton, ON, Canada
    BMC Emerg Med 13:14. 2013
    ..The objective of this study was therefore to determine if an optimal syringe size exists for conducting manual pediatric fluid resuscitation...
  9. pmc Do children with central venous line (CVL) dysfunction have increased risk of symptomatic thromboembolism compared to those without CVL-dysfunction, while on cancer therapy?
    Jacqueline Halton
    The Children s Hospital of Eastern Ontario CHEO, Ottawa, ON, Canada
    BMC Cancer 12:314. 2012
    ..Despite these observations, to date there are no prospective studies to evaluate the clinical significance of CVL-dysfunction and it's impact on the development of TE, infection, or outcome of children with cancer...
  10. pmc Trends and determining factors associated with adherence to antiretroviral therapy (ART) in Cameroon: a systematic review and analysis of the CAMPS trial
    Lawrence Mbuagbaw
    Centre for Development of Best Practices in Health CDBPH, Yaounde Central Hospital, Avenue Henri Dunant, Messa, PO Box 87, Yaounde, Cameroon
    AIDS Res Ther 9:37. 2012
    ..abstract:..
  11. pmc A tutorial on sensitivity analyses in clinical trials: the what, why, when and how
    Lehana Thabane
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    BMC Med Res Methodol 13:92. 2013
    ..The current paper is the second in a series of tutorial-type manuscripts intended to discuss and clarify aspects related to key methodological issues in the design and analysis of clinical trials...
  12. pmc The quality of reporting of RCTs used within a postoperative pain management meta-analysis, using the CONSORT statement
    Victoria Borg Debono
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, ON, L8N 3Z5, Canada
    BMC Anesthesiol 12:13. 2012
    ..abstract:..
  13. pmc Male participation in prevention programmes of mother to child transmission of HIV: a protocol for a systematic review to identify barriers, facilitators and reported interventions
    Frederick L I Morfaw
    Department of Obstetrics and Gynaecology, Faculty of Medicines and Biomedical Sciences, University of Yaounde 1, PO Box 1364, Yaounde, Cameroon
    Syst Rev 1:13. 2012
    ..We present a research protocol for a review which seeks to determine the effects of male participation on female uptake of PMTCT programs, and assess how this male participation has been investigated and documented worldwide...
  14. pmc The challenges and opportunities of conducting a clinical trial in a low resource setting: the case of the Cameroon mobile phone SMS (CAMPS) trial, an investigator initiated trial
    Lawrence Mbuagbaw
    Centre for the Development of Best Practices in Health CDBPH, Yaounde Central Hospital, Yaounde, Cameroon
    Trials 12:145. 2011
    ..It highlights administrative, ethical, financial and staff related issues, proposes solutions and gives a list of additional documentation to ease the organisational process...
  15. pmc The HAART cell phone adherence trial (WelTel Kenya1): a randomized controlled trial protocol
    Richard T Lester
    Department of Medical Microbiology, University of Nairobi, UNITID Building, Nairobi, Kenya
    Trials 10:87. 2009
    ..The objectives are to compare the effectiveness of cell phone-supported SMS messaging to standard care on adherence, quality of life, retention, and mortality in a population receiving antiretroviral therapy (ART) in Nairobi, Kenya...
  16. pmc The Cameroon mobile phone SMS (CAMPS) trial: a protocol for a randomized controlled trial of mobile phone text messaging versus usual care for improving adherence to highly active anti-retroviral therapy
    Lawrence Mbuagbaw
    Centre for the Development of Best Practices in Health CDBPH, Yaounde Central Hospital, Avenue Henri Dunant, Messa, PO Box 87, Yaounde, Cameroon
    Trials 12:5. 2011
    ..This trial aims at testing the efficacy of weekly reminder and motivational text messages, compared to usual care in improving adherence to Highly Active Antiretroviral Treatment in patients attending a clinic in Yaoundé, Cameroon...
  17. pmc Is plasma vitamin C an appropriate biomarker of vitamin C intake? A systematic review and meta-analysis
    Mahshid Dehghan
    Population Health Research Institute, School of Medicine, McMaster University, Hamilton, Canada
    Nutr J 6:41. 2007
    ..The purpose of this systematic review was to investigate the relationship between dietary vitamin C intakes measured by different dietary methods and plasma levels of vitamin C...
  18. pmc Parenting-by-gender interactions in child psychopathology: attempting to address inconsistencies with a Canadian national database
    Dillon T Browne
    Department of Psychology, University of Guelph, Guelph, Canada
    Child Adolesc Psychiatry Ment Health 4:5. 2010
    ..Future research should consider measuring and modelling variables that are assumed to explain such interactions when conducting gender-by-parenting research...
  19. pmc The Quality Initiative in Rectal Cancer (QIRC) trial: study protocol of a cluster randomized controlled trial in surgery
    Marko Simunovic
    Department of Surgery, McMaster University, St, Joseph s Healthcare, G838 50 Charlton Ave, East, Hamilton, Ontario, L8N 4A6, Canada
    BMC Surg 8:4. 2008
    ..The strategy is designed to optimize the use of total mesorectal excision techniques...
  20. pmc "Sleepiness" is serious in adolescence: two surveys of 3235 Canadian students
    Edward S Gibson
    Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada
    BMC Public Health 6:116. 2006
    ..of the study were to determine the level of sleepiness among students in high school, to identify factors to explain it, and to determine the association between sleepiness and performance in both academic and extracurricular activities..
  21. pmc Varied overground walking-task practice versus body-weight-supported treadmill training in ambulatory adults within one year of stroke: a randomized controlled trial protocol
    Vincent G Depaul
    School of Rehabilitation Sciences, McMaster University, Hamilton, Ontario, Canada
    BMC Neurol 11:129. 2011
    ....
  22. pmc Association between framing of the research question using the PICOT format and reporting quality of randomized controlled trials
    Lorena P Rios
    Biostatistics Unit, Father Sean O Sullivan Research Centre, St Joseph s Healthcare, 50 Charlton Avenue East, Hamilton ON L8N 4A6, Canada
    BMC Med Res Methodol 10:11. 2010
    ....
  23. pmc Systematic review of influenza resistance to the neuraminidase inhibitors
    Kristian Thorlund
    Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, Hamilton, L8N 3Z5 Ontario, Canada
    BMC Infect Dis 11:134. 2011
    ....
  24. pmc Metastatic renal cell cancer treatments: an indirect comparison meta-analysis
    Edward J Mills
    Faculty of Health Sciences, Simon Fraser University, Vancouver, Canada
    BMC Cancer 9:34. 2009
    ..New treatment options may provide improved progression-free survival (PFS). We aimed to determine the relative effectiveness of new therapies in this field...
  25. pmc A tutorial on pilot studies: the what, why and how
    Lehana Thabane
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton ON, Canada
    BMC Med Res Methodol 10:1. 2010
    ....
  26. pmc Canadian-led capacity-building in biostatistics and methodology in cardiovascular and diabetes trials: the CANNeCTIN Biostatistics and Methodological Innovation Working Group
    Lehana Thabane
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada
    Trials 12:48. 2011
    ..The ultimate goal is to enhance global health by contributing to efforts to reduce the burden of CVD and DM...
  27. ncbi request reprint Posing the research question: not so simple
    Lehana Thabane
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    Can J Anaesth 56:71-9. 2009
    ..We also provide a roadmap for applying the PICOT format in identifying and framing clear research questions...
  28. ncbi request reprint A closer look at the distribution of number needed to treat (NNT): a Bayesian approach
    Lehana Thabane
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton ON, Canada
    Biostatistics 4:365-70. 2003
    ..The posterior mode of the distribution is proposed as a point estimate and results are compared with the conventional method of estimation of NNT done by inversion...
  29. doi request reprint The effects and costs of a multifactorial and interdisciplinary team approach to falls prevention for older home care clients 'at risk' for falling: a randomized controlled trial
    Maureen Markle-Reid
    McMaster University, School of Nursing, Hamilton, Ontario
    Can J Aging 29:139-61. 2010
    ..Quality of life was improved, slips and trips were reduced, as were falls among males (75-84 years old) with a fear of falling or negative fall history...
  30. ncbi request reprint The safety of formoterol among patients with asthma using inhaled corticosteroids. Systematic review and meta-analysis
    Roman Jaeschke
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Pol Arch Med Wewn 118:627-35. 2008
    ....
  31. pmc Decision aid on radioactive iodine treatment for early stage papillary thyroid cancer--a randomized controlled trial
    Anna M Sawka
    Division of Endocrinology, Department of Medicine, University Health Network and University of Toronto, Toronto, Ontario, Canada
    Trials 11:81. 2010
    ..This decision is often difficult because of conflicting reports of RAI treatment benefit and medical evidence uncertainty due to the lack of long-term randomized controlled trials...
  32. pmc The utilization of appropriate osteoporosis medications improves following a multifaceted educational intervention: the Canadian quality circle project (CQC)
    George Ioannidis
    Department of Medicine, McMaster University, Hamilton, Canada
    BMC Med Educ 9:54. 2009
    ..However, appropriate therapy utilization of the disease remains suboptimal. Thus, the objective of the study was to change physicians' therapy administration behavior in accordance with the Osteoporosis Canada 2002 guidelines...
  33. ncbi request reprint Basis for physician recommendations for adjuvant radioiodine therapy in early-stage thyroid carcinoma: principal findings of the Canadian-American thyroid cancer survey
    Anna M Sawka
    Division of Endocrinology, Department of Medicine, University Health Network, Toronto, Ontario, Canada
    Endocr Pract 14:175-84. 2008
    ....
  34. ncbi request reprint Hip protectors decrease hip fracture risk in elderly nursing home residents: a Bayesian meta-analysis
    Anna M Sawka
    Division of Endocrinology and Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Clin Epidemiol 60:336-44. 2007
    ....
  35. doi request reprint An updated systematic review and commentary examining the effectiveness of radioactive iodine remnant ablation in well-differentiated thyroid cancer
    Anna M Sawka
    Department of Medicine, Division of Endocrinology, University Health Network, Toronto, ON, Canada
    Endocrinol Metab Clin North Am 37:457-80, x. 2008
    ..The incremental benefit of RRA in low risk patients with well-differentiated thyroid cancer after total or near-total thyroidectomy who are receiving thyroid hormone suppressive therapy remains unclear...
  36. pmc Optimizing care in osteoporosis: the Canadian quality circle project
    George Ioannidis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    BMC Musculoskelet Disord 9:130. 2008
    ....
  37. doi request reprint Shared electronic vascular risk decision support in primary care: Computerization of Medical Practices for the Enhancement of Therapeutic Effectiveness (COMPETE III) randomized trial
    Anne Holbrook
    Division of Clinical Pharmacology and Therapeutics, 105 Main Street E, Hamilton, Ontario, Canada
    Arch Intern Med 171:1736-44. 2011
    ..However, very few high-quality studies are set in routine, community-based clinical care, and no consistent evidence of an effect on patient outcomes has been found...
  38. pmc Alternatives to project-specific consent for access to personal information for health research: insights from a public dialogue
    Donald J Willison
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    BMC Med Ethics 9:18. 2008
    ..We sought to elicit public values in this matter and to work toward an agreement about a common approach to consent for use of personal information for health research through deliberative public dialogues...
  39. ncbi request reprint Are brand-name and generic warfarin interchangeable? A survey of Ontario patients and physicians
    Jennifer A Pereira
    Centre for Evaluation of Medicines, St Joseph s Healthcare, Hamilton, ON
    Can J Clin Pharmacol 12:e229-39. 2005
    ..The issue of therapeutic equivalence has been a source of controversy in Canada since the approval of generic warfarin products in 2000...
  40. doi request reprint Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin dalteparin: an assessment of safety and pharmacodynamics: the DIRECT study
    James Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Arch Intern Med 168:1805-12. 2008
    ..To challenge this premise, we evaluated if deep vein thrombosis (DVT) prophylaxis with dalteparin sodium confers an excessive anticoagulant effect in critically ill patients with severe renal insufficiency...
  41. ncbi request reprint What is the number of older Canadians needed to screen by measurement of bone density to detect an undiagnosed case of osteoporosis? a population-based study from CaMos
    Anna M Sawka
    Department of Medicine, Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    J Clin Densitom 9:413-8. 2006
    ..9%, 97.0%; 68 of 73) were not aware of it. Thus, the minimum NNS by BMD testing to detect one previously undiagnosed case of osteoporosis in Canada is: 6 women aged >or=65 yr, 13 men aged >or=65 yr, and 10 men aged >or=70 yr...
  42. pmc The cluster-randomized Quality Initiative in Rectal Cancer trial: evaluating a quality-improvement strategy in surgery
    Marko Simunovic
    Department of Surgery, McMaster University, St Joseph s Healthcare, Hamilton, Ontario, Canada
    CMAJ 182:1301-6. 2010
    ..Following surgery for rectal cancer, two unfortunate outcomes for patients are permanent colostomy and local recurrence of cancer. We tested whether a quality-improvement strategy to change surgical practice would improve these outcomes...
  43. pmc Consent for use of personal information for health research: do people with potentially stigmatizing health conditions and the general public differ in their opinions?
    Donald J Willison
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    BMC Med Ethics 10:10. 2009
    ..Little is known about the opinion of those who have more or less stigmatizing health conditions regarding the need for consent for use of their personal information for health research...
  44. pmc Assessment and implication of prognostic imbalance in randomized controlled trials with a binary outcome--a simulation study
    Rong Chu
    Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 7:e36677. 2012
    ....
  45. pmc Imputation strategies for missing binary outcomes in cluster randomized trials
    Jinhui Ma
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    BMC Med Res Methodol 11:18. 2011
    ....
  46. doi request reprint A systematic review examining the effects of therapeutic radioactive iodine on ovarian function and future pregnancy in female thyroid cancer survivors
    Anna M Sawka
    Division of Endocrinology, Department of Medicine, University Health Network Toronto, Ontario, Canada
    Clin Endocrinol (Oxf) 69:479-90. 2008
    ..For women with differentiated thyroid carcinoma (DTC), the effect of radioactive iodine (RAI) therapy on gonadal and reproductive function is an important consideration...
  47. pmc The impact of thyroid cancer and post-surgical radioactive iodine treatment on the lives of thyroid cancer survivors: a qualitative study
    Anna M Sawka
    Division of Endocrinology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 4:e4191. 2009
    ..Participants provided recommendations for healthcare providers on counseling future patients on adjuvant RAI treatment...
  48. pmc Efficacy of vitamin D supplementation in depression in adults: a systematic review protocol
    Guowei Li
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L8, Canada
    Syst Rev 2:64. 2013
    ....
  49. pmc An interdisciplinary knowledge translation intervention in long-term care: study protocol for the vitamin D and osteoporosis study (ViDOS) pilot cluster randomized controlled trial
    Courtney C Kennedy
    Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada
    Implement Sci 7:48. 2012
    ..This protocol describes the evaluation of a multifaceted, interdisciplinary KT intervention aimed at integrating evidence-based osteoporosis and fracture prevention strategies into LTC care processes...
  50. doi request reprint Integrated programs for mothers with substance abuse issues and their children: a systematic review of studies reporting on child outcomes
    Alison Niccols
    280 Holbrook Building, McMaster Children s Hospital Chedoke Site, Box 2000, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    Child Abuse Negl 36:308-22. 2012
    ....
  51. ncbi request reprint The use of hip protectors in long-term care facilities: a survey of nursing home staff
    Anna M Sawka
    Division of Endocrinology and Department of Medicine, University Health Network and University of Toronto, Ontario, Canada
    J Am Med Dir Assoc 8:229-32. 2007
    ..To determine the level of exposure to hip protectors and barriers to their use in nursing homes...
  52. doi request reprint Implementing a standardized community-based cardiovascular risk assessment program in 20 Ontario communities
    Megan Carter
    Elisabeth Bruyere Research Institute, Ottawa, Ontario, Canada
    Health Promot Int 24:325-33. 2009
    ..Monitoring delivery of a multi-community cardiovascular risk assessment program yielded key factors in program success to inform development of a sustainable and transferable model...
  53. pmc Comparing methods to estimate treatment effects on a continuous outcome in multicentre randomized controlled trials: a simulation study
    Rong Chu
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Health Sciences Centre, Room 2C7, 1200 Main Street West, Hamilton ON, L8N 3Z5, Canada
    BMC Med Res Methodol 11:21. 2011
    ..Our objective was to investigate the properties of commonly used statistical models at various levels of clustering in the context of multicentre RCTs...
  54. doi request reprint Second primary malignancy risk after radioactive iodine treatment for thyroid cancer: a systematic review and meta-analysis
    Anna M Sawka
    Division of Endocrinology and Department of Medicine, University Health Network, Toronto, Ontario, Canada
    Thyroid 19:451-7. 2009
    ..Our objective was to determine if the risk of SPMs is increased in individuals with thyroid cancer treated with radioactive iodine (RAI), compared to those not treated with RAI...
  55. pmc An interprofessional nurse-led mental health promotion intervention for older home care clients with depressive symptoms
    Maureen Markle-Reid
    School of Nursing, McMaster University, Hamilton, Ontario, Canada
    BMC Geriatr 14:62. 2014
    ....
  56. doi request reprint Hamilton acute pain service safety study: using root cause analysis to reduce the incidence of adverse events
    James E Paul
    From the Department of Anesthesia J E P, N B, R F M, L T, D M, J C and Department of Clinical Epidemiology and Biostatistics L T, McMaster University K A, Hamilton, Ontario, Canada Acute Pain Service NP, St Joseph s Healthcare K A, Hamilton, Ontario, Canada Clinical Practice and Education M K, Hamilton Health Sciences D B, M M, Hamilton, Ontario, Canada Advisor Health System Transformation, Hamilton Niagara Haldimand Brant Local Health Integration Network R F, Grimsby, Ontario, Canada
    Anesthesiology 120:97-109. 2014
    ..Root cause analysis, a process for identifying the causal factor(s) that underlie an adverse event, has the potential to identify and address system issues and thereby decrease the chance of recurrence of these complications...
  57. pmc An empirical comparison of methods for analyzing correlated data from a discrete choice survey to elicit patient preference for colorectal cancer screening
    Ji Cheng
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    BMC Med Res Methodol 12:15. 2012
    ....
  58. pmc Comparison of generalized estimating equations and quadratic inference functions using data from the National Longitudinal Survey of Children and Youth (NLSCY) database
    Adefowope Odueyungbo
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    BMC Med Res Methodol 8:28. 2008
    ..The quadratic inference functions (QIF) method extends the capabilities of GEE, while also addressing some GEE limitations...
  59. pmc Do patients perceive a link between a fragility fracture and osteoporosis?
    Lora Giangregorio
    Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada
    BMC Musculoskelet Disord 9:38. 2008
    ..To evaluate factors associated with whether patients associate their fracture with future fracture risk...
  60. ncbi request reprint Sex differences in hospital admissions from emergency departments in asthmatic adults: a population-based study
    Akerke Baibergenova
    McMaster University, Faculty of Health Sciences, Department of Clinical Epidemiology and Biostatistics, Centre for Evaluation of Medicines, St Joseph s Healthcare, Hamilton, Ontario, Canada
    Ann Allergy Asthma Immunol 96:666-72. 2006
    ..Analyzing the course of emergency department (ED) visits before hospital admission can help understanding of the mechanisms behind the excess of hospitalizations in women...
  61. ncbi request reprint Do hip protectors decrease the risk of hip fracture in institutional and community-dwelling elderly? A systematic review and meta-analysis of randomized controlled trials
    Anna M Sawka
    Division of Endocrinology and Department of Medicine, St Joseph s Healthcare and McMaster University, Hamilton, Ontario, Canada
    Osteoporos Int 16:1461-74. 2005
    ..Thus, there is little evidence to support the use of hip protectors outside the nursing home setting. The potential benefit of hip protectors in reducing hip fractures in nursing home residents requires further confirmation...
  62. pmc Does alendronate reduce the risk of fracture in men? A meta-analysis incorporating prior knowledge of anti-fracture efficacy in women
    Anna M Sawka
    Department of Medicine, St, Joseph s Healthcare and McMaster University, Hamilton, Ontario, Canada
    BMC Musculoskelet Disord 6:39. 2005
    ..Our objective was to systematically review the anti-fracture efficacy of alendronate in men with low bone mass or with a history of prevalent fracture(s) and incorporate prior knowledge of alendronate efficacy in women in the analysis...
  63. doi request reprint Gender differences among Canadian spousal caregivers at the end of life
    Kevin Brazil
    Department of Clinical Epidemiology and Biostatistics and Division of Palliative Care, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    Health Soc Care Community 17:159-66. 2009
    ..17, 95% CI = 0.05-0.53, P = 0.002). To address gender differences in caregiving, a realistic home-based palliative care approach must take into account the importance of informal caregivers...
  64. ncbi request reprint A systematic review of the gonadal effects of therapeutic radioactive iodine in male thyroid cancer survivors
    Anna M Sawka
    Division of Endocrinology, Department of Medicine, University Health Network Toronto, Ontario, Canada
    Clin Endocrinol (Oxf) 68:610-7. 2008
    ..For patients with well-differentiated thyroid carcinoma (WDTC), the gonadal effects of radioactive iodine (RAI) therapy is an important consideration...
  65. ncbi request reprint Sample sizes for clinical trials using sputum eosinophils as a primary outcome
    Angira Dasgupta
    St Joseph s Healthcare and McMaster University, Hamilton, ON
    Eur Respir J 42:1003-11. 2013
    ..Assuming a minimal clinically important reduction of 15% in absolute terms, 18 subjects in each arm will be required to achieve 80% power using an ANCOVA analysis, which we recommend, to detect significance with an alpha error of 0.05. ..
  66. ncbi request reprint Efficacy of vitamin D supplementation in depression in adults: a systematic review
    Guowei Li
    Department of Clinical Epidemiology and Biostatistics G L, L M, S Z, J C, L T, and Department of Psychiatry and Behavioural Neurosciences Z S, Division of Geriatric Medicine, Department of Medicine A P, McMaster University, Hamilton, Ontario, Canada L8S 4L8 Post Graduate Program in Epidemiology M F, Universidade Federal do Rio Grande do Sul, Porto Alegre 90040 060, Brazil and St Joseph s Hospital J D A, J C, L T, McMaster University, Hamilton, Ontario, Canada L8N 4A6
    J Clin Endocrinol Metab 99:757-67. 2014
    ..Randomized controlled trials (RCTs) investigating the efficacy of vitamin D (Vit D) in depression provided inconsistent results...
  67. pmc The effect of regular physical activity on bone mineral density in post-menopausal women aged 75 and over: a retrospective analysis from the Canadian multicentre osteoporosis study
    Jeffrey M Muir
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    BMC Musculoskelet Disord 14:253. 2013
    ..Physical activity is known to benefit many physiological processes, including bone turnover. There are; however, currently no clinical guidelines regarding the most appropriate type, intensity and duration of activity to prevent bone loss...
  68. doi request reprint Gabapentin does not improve multimodal analgesia outcomes for total knee arthroplasty: a randomized controlled trial
    James E Paul
    Department of Anesthesia, McMaster University, Hamilton, ON, Canada
    Can J Anaesth 60:423-31. 2013
    ....
  69. pmc Preferences for evidence-based practice dissemination in addiction agencies serving women: a discrete-choice conjoint experiment
    Charles E Cunningham
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, McMaster Children s Hospital, Hamilton, Ontario, Canada
    Addiction 107:1512-24. 2012
    ..To model variables influencing the dissemination of evidence-based practices to addiction service providers and administrators...
  70. pmc Comparison of population-averaged and cluster-specific models for the analysis of cluster randomized trials with missing binary outcomes: a simulation study
    Jinhui Ma
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    BMC Med Res Methodol 13:9. 2013
    ..e. generalized estimating equations (GEE)) and cluster-specific (i.e. random-effects logistic regression (RELR)) models for analyzing data from cluster randomized trials (CRTs) with missing binary responses...
  71. pmc Reporting of feasibility factors in publications on integrated treatment programs for women with substance abuse issues and their children: a systematic review and analysis
    Joanna Henderson
    Child, Youth and Family Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Health Res Policy Syst 10:37. 2012
    ..Researcher attention to the applicability of findings to applied settings also has increased. Much less attention, however, has been paid to intervention feasibility, an issue important to applied settings...
  72. doi request reprint The effect of delivery method on breastfeeding initiation from the The Ontario Mother and Infant Study (TOMIS) III
    Susan Watt
    School of Social Work, McMaster University, Hamilton, ON, Canada
    J Obstet Gynecol Neonatal Nurs 41:728-37. 2012
    ..To report on the relationship between delivery method (cesarean vs. vaginal) and type (planned vs. unplanned) and breastfeeding initiation in hospital and continuation to 6 weeks postpartum as self-reported by study participants...
  73. pmc Improvement in health-related quality of life in osteoporosis patients treated with teriparatide
    Arthur N Lau
    Division of Rheumatology and Department of Medicine, St, Joseph s Healthcare and McMaster University, Hamilton, Ontario, Canada
    BMC Musculoskelet Disord 9:151. 2008
    ..To determine whether patients with osteoporosis treated with teriparatide experienced improvement in HRQL and pain symptoms after several months of therapy...
  74. ncbi request reprint Does celecoxib potentiate the anticoagulant effect of warfarin? A randomized, double-blind, controlled trial
    Francesco Dentali
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Ann Pharmacother 40:1241-7. 2006
    ..Cyclooxygenase-2 selective NSAIDs such as celecoxib may be less likely to promote gastrointestinal bleeding; however, there are concerns that they could potentiate the anticoagulation effect of warfarin...
  75. ncbi request reprint Is fetal gender associated with emergency department visits for asthma during pregnancy?
    Akerke Baibergenova
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Asthma 43:293-9. 2006
    ..To investigate if fetal gender (1) affects the risk of having an emergency department (ED) visit for asthma; and (2) is associated with adverse pregnancy outcomes among women who had at least one visit to the ED for asthma during pregnancy...
  76. ncbi request reprint Patient characteristics associated with nocturnal emergency department visits for asthma
    Akerke Baibergenova
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Asthma 43:469-75. 2006
    ..To identify patient characteristics associated with nocturnal emergency department (ED) visits for asthma...
  77. doi request reprint Family physicians' personal and practice characteristics that are associated with improved utilization of bone mineral density testing and osteoporosis medication prescribing
    George Ioannidis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Popul Health Manag 12:131-8. 2009
    ..The education of both clinicians and policy makers regarding these new insights may translate to enhanced individual practices and an improved overall health care system to optimize the environment for managing osteoporosis...
  78. pmc Safety and tolerability of varenicline tartrate (Champix(®)/Chantix(®)) for smoking cessation in HIV-infected subjects: a pilot open-label study
    Qu Cui
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    AIDS Patient Care STDS 26:12-9. 2012
    ..The most common AE was nausea, with no adverse effect on HIV treatment outcome. Close monitoring of liver enzymes and blood pressure is recommended for HIV-positive smokers taking varenicline...
  79. ncbi request reprint Interprofessional stroke rehabilitation for stroke survivors using home care
    Maureen Markle-Reid
    School of Nursing, McMaster University, Hamilton, Ontario, Canada
    Can J Neurol Sci 38:317-34. 2011
    ..To compare a specialized interprofessional team approach to community-based stroke rehabilitation with usual home care for stroke survivors using home care services...
  80. ncbi request reprint Quality improvement in colorectal cancer in local health integration network 4 (LHIN 4) project (QICC-L4): integrated knowledge translation in a large geographic region
    Marko Simunovic
    Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    Ann Surg Oncol 20:4067-72. 2013
    ..We tested if such an approach could improve the quality of colorectal cancer surgery in a large geographic region (i.e., LHIN4) in Ontario, Canada...
  81. ncbi request reprint Feasibility study of walking for exercise in individuals living in assisted living settings
    Jenna A Johnson
    1Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada 2Toronto Rehabilitation Institute, Toronto, Ontario, Canada 3Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada 4Department of Medicine, McMaster University, Hamilton, Ontario, Canada 5Centre for Evaluation of Medicines, St Joseph s Healthcare, Hamilton, Ontario, Canada
    J Geriatr Phys Ther 36:175-81. 2013
    ..Secondary objectives were to determine whether older adults could achieve the frequency, intensity, and duration of aerobic exercise recommended by the American College of Sports Medicine...
  82. doi request reprint The prognostic value of pre-operative and post-operative B-type natriuretic peptides in patients undergoing noncardiac surgery: B-type natriuretic peptide and N-terminal fragment of pro-B-type natriuretic peptide: a systematic review and individual patien
    Reitze N Rodseth
    Perioperative Research Group, Department of Anaesthetics, Grey s Hospital, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Pietermaritzburg, South Africa Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada Department of Outcomes Research, Cleveland Clinic, Cleveland, Ohio Electronic address
    J Am Coll Cardiol 63:170-80. 2014
    ..e., B-type natriuretic peptide [BNP] and N-terminal fragment of proBNP [NT-proBNP]) enhances risk stratification in adult patients undergoing noncardiac surgery, in whom a pre-operative NP has been measured...
  83. pmc Uptake of an innovation in surgery: observations from the cluster-randomized Quality Initiative in Rectal Cancer trial
    Marko Simunovic
    The Department of Surgery, McMaster University, St Joseph s Healthcare, Hamilton, Ont, The Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, Hamilton, Ont, and the Department of Oncology, Faculty of Health Sciences, Juravinski Cancer Centre, Hamilton, Ont
    Can J Surg 56:415-21. 2013
    ..We tested if traditional uptake of innovation concepts applied to surgeons in the experimental arm of the trial...
  84. pmc The impact of a cardiovascular health awareness program (CHAP) on reducing blood pressure: a prospective cohort study
    Chenglin Ye
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    BMC Public Health 13:1230. 2013
    ..We aimed to evaluate the effect of a community-based Cardiovascular Health Awareness Program (CHAP) on participants' blood pressure...
  85. doi request reprint The general public's willingness to pay for tax increases to support unrestricted access to an Alzheimer's disease medication
    Mark Oremus
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    Pharmacoeconomics 30:1085-95. 2012
    ..Alzheimer's disease (AD) is a neurodegenerative disorder highlighted by progressive declines in cognitive and functional abilities...
  86. pmc Relation between fractures and mortality: results from the Canadian Multicentre Osteoporosis Study
    George Ioannidis
    Department of Medicine, McMaster University, Hamilton, Ont
    CMAJ 181:265-71. 2009
    ..Fractures have largely been assessed by their impact on quality of life or health care costs. We conducted this study to evaluate the relation between fractures and mortality...
  87. ncbi request reprint A systematic review of the effect of alendronate on bone mineral density in men
    Anna M Sawka
    McMaster University, Hamilton, Ontario, Canada L8N 1Y2
    J Clin Densitom 8:7-13. 2005
    ..We conclude that 10 mg of oral daily alendronate is significantly associated with increase in BMD at the lumbar spine and hip in men over 2-3 yr and that these changes are similar to those previously observed in postmenopausal women...
  88. pmc Evolution of heterogeneity (I2) estimates and their 95% confidence intervals in large meta-analyses
    Kristian Thorlund
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 7:e39471. 2012
    ..However, no previous studies have explored how many trials and events are required to ensure stable and reliable I(2) estimates, or how 95% CIs perform as evidence accumulates...
  89. doi request reprint Femoral nerve block improves analgesia outcomes after total knee arthroplasty: a meta-analysis of randomized controlled trials
    James E Paul
    Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada
    Anesthesiology 113:1144-62. 2010
    ..We conducted a systematic review to compare the analgesia outcomes in randomized controlled trials that compared FNB (with and without sciatic nerve block) with epidural and patient-controlled analgesia (PCA)...
  90. pmc Bayesian hierarchical models combining different study types and adjusting for covariate imbalances: a simulation study to assess model performance
    C Elizabeth McCarron
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 6:e25635. 2011
    ..The objective of this study was to assess the performance of a proposed Bayesian approach to adjust for imbalances in patient level covariates when combining evidence from both types of study designs...
  91. pmc Features predicting the success of computerized decision support for prescribing: a systematic review of randomized controlled trials
    Brent Mollon
    The Centre for Evaluation of Medicines, McMaster University, Hamilton, Ontario, Canada
    BMC Med Inform Decis Mak 9:11. 2009
    ..We conducted a systematic review to evaluate whether certain features of prescribing decision support systems (RxCDSS) predict successful implementation, change in provider behaviour, and change in patient outcomes...
  92. pmc Maternal substance use and integrated treatment programs for women with substance abuse issues and their children: a meta-analysis
    Karen Milligan
    Integra, 25 Imperial Street, Toronto, ON, M5P 1B9, Canada
    Subst Abuse Treat Prev Policy 5:21. 2010
    ..This synthesis and meta-analysis reviews research in this important and growing area of treatment...
  93. pmc Methodologic issues in health informatics trials: the complexities of complex interventions
    Ivan Shcherbatykh
    Centre for Evaluation of Medicines, St Joseph s Healthcare Hamilton, Hamilton, Ontario L8N1G6, Canada
    J Am Med Inform Assoc 15:575-80. 2008
    ..CONCLUSIONS Our recommendations emphasize validity and pragmatic considerations and would be useful for health informaticians conducting or evaluating e-health studies...
  94. ncbi request reprint Tips on overlapping confidence intervals and univariate linear models
    Adefowope Odueyungbo
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Nurse Res 16:73-83. 2009
    ..Further, using a model that includes baseline response as covariate leads to more precise estimates. The implications for future trials are discussed...
  95. pmc Frailty index of deficit accumulation and falls: data from the Global Longitudinal Study of Osteoporosis in Women (GLOW) Hamilton cohort
    Guowei Li
    Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4 L8, Canada
    BMC Musculoskelet Disord 15:185. 2014
    ..To investigate the association between frailty index (FI) of deficit accumulation and risk of falls, fractures, death and overnight hospitalizations in women aged 55 years and older...
  96. pmc Patterns of use and outcomes for radiation therapy in the Quality Initiative in Rectal Cancer (QIRC) trial
    Valerie Francescutti
    From the Department of Surgery, McMaster University, Hamilton, Ont
    Can J Surg 56:E148-53. 2013
    ..We wished to identify associations between local recurrence risk and use of preoperative, postoperative or no RT...
  97. pmc Empirical comparison of methods for analyzing multiple time-to-event outcomes in a non-inferiority trial: a breast cancer study
    Sameer Parpia
    Ontario Clinical Oncology Group, Department of Oncology, McMaster University, 711 Concession Street G 60 Wing 1st Floor, Hamilton, ON L8V 1C3, Canada
    BMC Med Res Methodol 13:44. 2013
    ..However, their application to non-inferiority trials is limited. We evaluate four statistical methods for multiple time-to-event endpoints in the context of a non-inferiority trial...
  98. pmc Modelling heterogeneity variances in multiple treatment comparison meta-analysis--are informative priors the better solution?
    Kristian Thorlund
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    BMC Med Res Methodol 13:2. 2013
    ..Relaxing the homogeneous variance assumption may be equally problematic due to reduced precision. To regain good precision, moderately informative variance priors or additional mathematical assumptions may be necessary...
  99. doi request reprint Early mobilization in critically ill children: a survey of Canadian practice
    Karen Choong
    Department of Pediatrics, McMaster University, Hamilton, ON, Canada
    Crit Care Med 41:1745-53. 2013
    ..The objective of this study was to evaluate the knowledge, perceptions, and stated practices of early mobilization among physicians and physiotherapists practicing in Canadian pediatric critical care units...