Research Topics
Genomes and GenesSpecies | K K TeoSummaryAffiliation: McMaster University Country: Canada Publications
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Publications
Evaluating the effectiveness of rosuvastatin in preventing the progression of diastolic dysfunction in aortic stenosis: A substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) studyDavinder S Jassal
Cardiology Division, Department of Internal Medicine, St Boniface General Hospital, Winnipeg, Manitoba, Canada
Cardiovasc Ultrasound 9:5. 2011..Little is known however, on the utility of TDI in the serial assessment of diastolic abnormalities in AS...
Who should receive HMG CoA reductase inhibitors?Koon K Teo
Division of Cardiology, McMaster University, Hamilton, Ontario, Canada
Drugs 62:1707-15. 2002..There is evidence of a 'care gap' in translating trial data into practice, even in secondary prevention, and this needs closing in order to improve patient outcomes...
Rationale, design, and baseline characteristics of 2 large, simple, randomized trials evaluating telmisartan, ramipril, and their combination in high-risk patients: the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial/TelmiKoon Teo
McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
Am Heart J 148:52-61. 2004..Baseline patient characteristics are comparable to the Heart Outcomes Prevention Evaluation (HOPE) trial, the basis of the design of the current study, confirming that patients are at high-risk...
Effect of ramipril in reducing sudden deaths and nonfatal cardiac arrests in high-risk individuals without heart failure or left ventricular dysfunctionKoon K Teo
Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
Circulation 110:1413-7. 2004....
Primary prevention in chronic ischemic heart diseaseKoon K Teo
McMaster University, Hamilton, Ontario, Canada
Card Electrophysiol Rev 6:15-7. 2002
Potentially modifiable risk factors associated with myocardial infarction in China: the INTERHEART China studyK K Teo
Population Health Research Institute, McMaster University Hamilton Health Sciences, Hamilton, Ontario, Canada
Heart 95:1857-64. 2009..Lifestyle changes associated with the rapidly developing economy increase cardiovascular disease (CVD), myocardial infarction (MI) and cardiovascular risk factors (CVRFs) in China...
Polypill: lights and shadowsKoon K Teo
McMaster University Medical Centre, Rm 3U4, 1200 Main Street West, Hamilton, ON, L8N 3Z5, Canada
Curr Hypertens Rep 12:276-81. 2010..The polypill was well tolerated. Challenges to be resolved include the need to demonstrate conclusively the safety and efficacy of the polypill in large clinical end point trials...
Lipid lowering on progression of mild to moderate aortic stenosis: meta-analysis of the randomized placebo-controlled clinical trials on 2344 patientsKoon K Teo
Population Health Research Institute, McMaster University, and Hamilton General Hospital, Hamilton, Ontario, Canada
Can J Cardiol 27:800-8. 2011..Randomized trials, however, reported neutral results. This meta-analysis of randomized lipid trials on patients with AS examined the effects of treatment on AS progression and clinical outcomes...
Effects of long-term treatment with angiotensin-converting-enzyme inhibitors in the presence or absence of aspirin: a systematic reviewKoon K Teo
Population Health Research Institute and Division of Cardiology, McMaster University, Ontario, Hamilton, Canada
Lancet 360:1037-43. 2002..We aimed to confirm or refute this theory...
The Study of Health Assessment and Risk in Ethnic groups (SHARE): rationale and design. The SHARE InvestigatorsS S Anand
Preventive Cardiology and Therapeutics Research Program, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario
Can J Cardiol 14:1349-57. 1998..The relationship between the conventional and emerging risk factors, and atherosclerosis, vascular disease and markers of end-organ damage will be evaluated between and within ethnic groups...
Differences in risk factors, atherosclerosis, and cardiovascular disease between ethnic groups in Canada: the Study of Health Assessment and Risk in Ethnic groups (SHARE)S S Anand
Department of Medicine, McMaster University, Ontario, Canada
Lancet 356:279-84. 2000..To establish whether this variation can be explained by differences in disease risk factors and subclinical atherosclerosis, we undertook a population-based study of three ethnic groups in Canada: South Asians, Chinese, and Europeans...
Use of secondary prevention drugs for cardiovascular disease in the community in high-income, middle-income, and low-income countries (the PURE Study): a prospective epidemiological surveySalim Yusuf
Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada
Lancet 378:1231-43. 2011....
The Prospective Urban Rural Epidemiology (PURE) study: examining the impact of societal influences on chronic noncommunicable diseases in low-, middle-, and high-income countriesKoon Teo
Population Health Research Institute, McMaster University Hamilton Health Sciences, Hamilton, Ontario, Canada
Am Heart J 158:1-7.e1. 2009..The overarching aim of the study is to examine the relationship of societal influences on human lifestyle behaviors, cardiovascular risk factors, and incidence of chronic noncommunicable diseases...
Psychosocial components of cardiac recovery and rehabilitation attendanceK M King
EPICORE Centre CQIN, Division of Cardiology, 213 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
Heart 85:290-4. 2001..To examine the relations between demographic factors, specific psychosocial factors, and cardiac rehabilitation attendance...
ACE inhibitors in heart failure: what more do we need to know?Catherine Demers
Department of Medicine, Division of Cardiology, McMaster University, Hamilton, Ontario, Canada
Am J Cardiovasc Drugs 5:351-9. 2005..Although the use of ACE inhibitors may be appealing in patients with HF and preserved LV systolic function, there is currently no evidence from large clinical trials to support this...
Long-term effects of cholesterol lowering and angiotensin-converting enzyme inhibition on coronary atherosclerosis: The Simvastatin/Enalapril Coronary Atherosclerosis Trial (SCAT)K K Teo
University of Alberta Hospitals, Edmonton, Alberta, Canada
Circulation 102:1748-54. 2000....
Telmisartan, ramipril, or both in patients at high risk for vascular eventsSalim Yusuf
Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
N Engl J Med 358:1547-59. 2008..We compared the ACE inhibitor ramipril, the ARB telmisartan, and the combination of the two drugs in patients with vascular disease or high-risk diabetes...
Defining obesity cut points in a multiethnic populationFahad Razak
Population Health Research Institute, McMaster University, Hamilton, ON, Canada
Circulation 115:2111-8. 2007..It is unknown whether these cut points are appropriate for non-European populations. We assessed the metabolic risk associated with BMI among South Asians, Chinese, Aboriginals, and Europeans...
Diagnostic strategies to detect glucose intolerance in a multiethnic populationSonia S Anand
Department of Medicine, Division of Cardiology and Population Health Research Institute, McMaster University, Ontario, Canada
Diabetes Care 26:290-6. 2003....
Estimated glomerular filtration rate and albuminuria as predictors of outcomes in patients with high cardiovascular risk: a cohort studyCatherine M Clase
McMaster University and Population Health Research Institute, Hamilton, Canada
Ann Intern Med 154:310-8. 2011..Glomerular filtration rate and albuminuria are risk factors for cardiovascular disease and markers of renal function...
Ramipril in the treatment of vascular diseasesMichael J Rokoss
Division of Cardiology, McMaster University, Room 3U4 McMaster University Medical Centre, Hamilton, Ontario, L8N 3Z5, Canada
Expert Opin Pharmacother 6:1911-9. 2005....
Ethnic differences in the relationships between obesity and glucose-metabolic abnormalities: a cross-sectional population-based studyF Razak
Population Health Research Institute, McMaster University, Hamilton General Hospital, Hamilton, ON, Canada
Int J Obes (Lond) 29:656-67. 2005..Existing action thresholds for these anthropometric indices do not apply to non-European ethnic groups and warrant revision...
Predicting and explaining cardiac rehabilitation attendanceK M King
Division of Cardiology, University of Alberta, Edmonton, Canada
Can J Cardiol 17:291-6. 2001..A variety of factors influence patients' health behaviour; these are patterns of practitioner practice, patient characteristics and availability of resources...
Blocking the renin-angiotensin system: dual- versus mono-therapyAmir Ravandi
Division of Cardiology and Population Health Research Institute, McMaster University, Hamilton, ON L8N 3Z5, Canada
Expert Rev Cardiovasc Ther 7:667-74. 2009..Overall, patients receiving dual therapy, if clinically justified, should be monitored closely for potential adverse effects...
Replication of genetic associations with plasma lipoprotein traits in a multiethnic sampleMatthew B Lanktree
Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
J Lipid Res 50:1487-96. 2009..The findings indicate the potential utility of the Illumina CVD beadchip, but they underscore the need to consider meta-analysis of results from commonly studied clinical or epidemiological samples...
Impact of managed waiting for coronary artery bypass graft surgery on patients' perceived quality of lifeK K Teo
Division of Cardiology, University of Alberta Hospitals, Edmonton, Canada
Circulation 98:II29-33; discussion II33-4. 1998..This study was designed to determine how being placed on a managed waiting list for > 6 weeks for CABG surgery affected patients' perceived quality of life in a Canadian center...
Study of Cardiovascular Risk Intervention by Pharmacists (SCRIP): a randomized trial design of the effect of a community pharmacist intervention program on serum cholesterol riskR T Tsuyuki
Division of Cardiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada
Ann Pharmacother 33:910-9. 1999..To determine the efficacy of a program of intervention by pharmacists on lipid risk management in patients at high risk for cardiovascular events...
Optimal medical therapy with or without percutaneous coronary intervention in older patients with stable coronary disease: a pre-specified subset analysis of the COURAGE (Clinical Outcomes Utilizing Revascularization and Aggressive druG Evaluation) trialKoon K Teo
McMaster University Medical Center, Hamilton, Ontario, Canada
J Am Coll Cardiol 54:1303-8. 2009..Our aim was to access clinical effectiveness of percutaneous coronary intervention (PCI) when added to optimal medical therapy (OMT) in older patients with stable coronary artery disease (CAD)...
Effects of long term resistance training on left ventricular morphologyM J Haykowsky
The Faculty of Physical Education and Recreation, Division of Cardiology, University of Alberta, Edmonton, Canada
Can J Cardiol 16:35-8. 2000..To assess the effects of long term (mean +/- SD 10+/-5 years, range three to 25 years) resistance training on left ventricular (LV) dimensions and mass...
Canadian quality indicators for percutaneous coronary interventionsDennis T Ko
Institute for Clinical Evaluative Sciences, Ontario, Canada
Can J Cardiol 24:899-903. 2008..However, quality indicators for percutaneous coronary intervention (PCI) have not been developed in Canada...
Effectiveness of comprehensive disease management programmes in improving clinical outcomes in heart failure patients. A meta-analysisRosa Roccaforte
Population Health Research Institute, McMaster University, and Hamilton Health Sciences, Ontario, Canada
Eur J Heart Fail 7:1133-44. 2005..Disease management programmes (DMP) have been advocated to improve long term outcomes of heart failure (HF) patients...
Interrelation of saturated fat, trans fat, alcohol intake, and subclinical atherosclerosisAnwar T Merchant
Population Health Research Institute, Hamilton, Ontario, Canada
Am J Clin Nutr 87:168-74. 2008..Intake of saturated fat, trans fat, and alcohol alter cardiovascular disease risk, but their effect on subclinical atherosclerosis remains understudied...
Predictors of improvement in left ventricular function after percutaneous revascularization of occluded coronary arteries: a report from the Total Occlusion Study of Canada (TOSCA)V Dzavik
University Health Network, Toronto, Ontario, Canada
Am Heart J 142:301-8. 2001....
Tobacco use and risk of myocardial infarction in 52 countries in the INTERHEART study: a case-control studyKoon K Teo
Population Health Research Institute, McMaster University-Hamilton Health Sciences, Hamilton, ON L8L 2X2, Canada
Lancet 368:647-58. 2006..All forms of tobacco use, including different types of smoking and chewing tobacco and inhalation of SHS, should be discouraged to prevent cardiovascular diseases...
Effects of exercise training in patients with heart failure: the Exercise Rehabilitation Trial (EXERT)Robert S McKelvie
Division of Cardiology and Preventive Cardiology and Therapeutic Program, Hamilton Health Sciences Corporation, Hamilton, Ontario, Canada
Am Heart J 144:23-30. 2002..The purpose of this study was to examine the effects of exercise training on functional capacity in patients with heart failure...
Blood volume expansion and cardiorespiratory function: effects of training modalityDarren E R Warburton
Division of Cardiology, Faculty of Medicine and Faculty of Physical Education and Recreation, University of Alberta, Edmonton Alberta, Canada
Med Sci Sports Exerc 36:991-1000. 2004..We hypothesized that if modality-mediated differences in cardiorespiratory function exist after INT and CONT, they would be related directly to differences in training-induced hypervolemia...
Effect of bare metal stenting on angiographic and clinical outcomes in diabetic and nondiabetic patients undergoing percutaneous coronary intervention of nonacute occluded coronary arteries: a report from the Total Occlusion Study of Canada (TOSCA)Kok-Meng Yee
Division of Cardiology, University Health Network, Toronto, Ontario, Canada
Catheter Cardiovasc Interv 66:178-84. 2005..This analysis forms an important background for future studies that are needed to examine the effect of stenting with drug-eluting stents in diabetics as well as nondiabetics with nonacute coronary occlusions...
Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trialJohannes F E Mann
Schwabing General Hospital, and KfH Kidney Centre, Ludwig Maximilians University Munchen, Germany
Lancet 372:547-53. 2008..We investigated the renal effects of ramipril (an ACE inhibitor), telmisartan (an ARB), and their combination in patients aged 55 years or older with established atherosclerotic vascular disease or with diabetes with end-organ damage...
Optimal medical therapy with or without percutaneous coronary intervention to reduce ischemic burden: results from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial nuclear substudyLeslee J Shaw
Emory University School of Medicine, Atlanta, GA 30306, USA
Circulation 117:1283-91. 2008....
The role of the data coordinating center in the IRB review and approval process: the DIG trial experienceJoseph F Collins
Department of Veterans Affairs, Cooperative Studies Program, Perry Point, Maryland 21902, USA
Control Clin Trials 24:306S-315S. 2003..This enabled the study to be completed on schedule and within budget...
Associations of plasma homocysteine and the methylenetetrahydrofolate reductase C677T polymorphism with carotid intima media thickness among South Asian, Chinese and European CanadiansLinda E Kelemen
Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, USA
Atherosclerosis 176:361-70. 2004..Few studies have evaluated the associations of plasma homocysteine concentration, the methylenetetrahydrofolate reductase (MTHFR) C677T genotype and B vitamin concentration with intima media thickness (IMT) in multiethnic populations...
ACE inhibition in secondary prevention: are the results controversial?Erik B Friedrich
Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Kirrberger Strasse, 66421 Homburg Saar, Germany
Clin Res Cardiol 95:61-7. 2006..Further studies are needed to try to resolve this issue. In the meantime, the overwhelming data still support the use of ACE inhibitors in patients with coronary artery disease with preserved left ventricular function...
Design and rationale of the Clinical Outcomes Utilizing Revascularization and Aggressive DruG Evaluation (COURAGE) trial Veterans Affairs Cooperative Studies Program no. 424William E Boden
VA Connecticut Healthcare System, West Haven, CT, USA
Am Heart J 151:1173-9. 2006....
Impact of ramipril on the circadian periodicity of acute myocardial infarctionGilles R Dagenais
University Heart and Lung Institute, Laval Hospital, and the Department of Medicine, Laval University, Quebec, Quebec, Canada
Am J Cardiol 98:758-60. 2006..In conclusion, inhibiting angiotensin-converting enzyme decreased AMI over a 24-hour period, but this enzyme does not seem to play a major role in the circadian periodicity of this acute event...
The evolving pattern of symptomatic coronary artery disease in the United States and Canada: baseline characteristics of the Clinical Outcomes Utilizing Revascularization and Aggressive DruG Evaluation (COURAGE) trialWilliam E Boden
VA Connecticut Healthcare System, West Haven, Connecticut, USA
Am J Cardiol 99:208-12. 2007....
Optimal medical therapy with or without PCI for stable coronary diseaseWilliam E Boden
Western New York Veterans Affairs Healthcare Network and Buffalo General Hospital SUNY, Buffalo, NY 14203, USA
N Engl J Med 356:1503-16. 2007....
Does chronic Chlamydia pneumoniae infection increase the risk of myocardial injury? Insights from patients with non-ST-elevation acute coronary syndromesBrian Y L Wong
University of Alberta, Edmonton, Alberta, Canada
Am Heart J 144:987-94. 2002..Accordingly, we evaluated plasma samples acquired at presentation in 178 patients with ACS for a possible association between Cpn IgA titer and biochemical evidence of myocardial injury...
The relative importance of barriers to the prescription of warfarin for nonvalvular atrial fibrillationTammy J Bungard
Division of Cardiology, University of Alberta, Edmonton
Can J Cardiol 19:280-4. 2003..The use of decision support technologies would facilitate involvement of the patient and serve to educate both the patient and physician on the risks and benefits of warfarin therapy...
Effects of long term cholesterol lowering on coronary atherosclerosis in patient risk factor subgroups: the Simvastatin/enalapril Coronary Atherosclerosis Trial (SCAT)Jeffrey R Burton
University of Alberta Hospitals and Department of Medicine, University of Alberta, Edmonton
Can J Cardiol 19:487-91. 2003..Also, this treatment effect occurs in the presence or absence of the traditional coronary risk factors...
Development and evaluation of cultural food frequency questionnaires for South Asians, Chinese, and Europeans in North AmericaLinda E Kelemen
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
J Am Diet Assoc 103:1178-84. 2003..Lower correlations for dietary fats among Chinese persons (0.17 to 0.31) may be improved with more direct questions on the FFQ regarding brand, type, and amount of oil consumed in stirfry servings...
A randomized trial of the effect of community pharmacist intervention on cholesterol risk management: the Study of Cardiovascular Risk Intervention by Pharmacists (SCRIP)Ross T Tsuyuki
Epidemiology Coordinating and Research EPICORE Centre, Division of Cardiology, University of Alberta, 213 Heritage Medical Research Centre, Edmonton, Alberta, Canada T6G 2S2
Arch Intern Med 162:1149-55. 2002..This study aimed to determine the effect of a program of community pharmacist intervention on the process of cholesterol risk management in patients at high risk for cardiovascular events...
Effect of PCI on quality of life in patients with stable coronary diseaseWilliam S Weintraub
Christiana Care Health System, Newark, DE 19718, USA
N Engl J Med 359:677-87. 2008..It has not been clearly established whether percutaneous coronary intervention (PCI) can provide an incremental benefit in quality of life over that provided by optimal medical therapy among patients with chronic coronary artery disease...
