M Tarnopolsky

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint Mitochondrial myopathies: diagnosis, exercise intolerance, and treatment options
    Mark A Tarnopolsky
    McMaster University Medical Center, Hamilton, Ontario, Canada
    Med Sci Sports Exerc 37:2086-93. 2005
  2. doi request reprint Exercise, sex, menstrual cycle phase, and 17beta-estradiol influence metabolism-related genes in human skeletal muscle
    Ming hua H Fu
    Department of Kinesiology, McMaster University, Hamilton, ON L8S 3Z5, Canada
    Physiol Genomics 40:34-47. 2009
  3. pmc Eccentric exercise activates novel transcriptional regulation of hypertrophic signaling pathways not affected by hormone changes
    Lauren G MacNeil
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 5:e10695. 2010
  4. pmc Elevated mitochondrial oxidative stress impairs metabolic adaptations to exercise in skeletal muscle
    Justin D Crane
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 8:e81879. 2013
  5. pmc Aberrant mitochondrial homeostasis in the skeletal muscle of sedentary older adults
    Adeel Safdar
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 5:e10778. 2010
  6. pmc Supplementation with α-lipoic acid, CoQ10, and vitamin E augments running performance and mitochondrial function in female mice
    Arkan Abadi
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 8:e60722. 2013
  7. pmc Markers of skeletal muscle mitochondrial function and lipid accumulation are moderately associated with the homeostasis model assessment index of insulin resistance in obese men
    Imtiaz A Samjoo
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 8:e66322. 2013
  8. pmc Limb immobilization induces a coordinate down-regulation of mitochondrial and other metabolic pathways in men and women
    Arkan Abadi
    Department of Pediatrics and Medicine, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 4:e6518. 2009
  9. pmc Sex differences in global mRNA content of human skeletal muscle
    Amy C Maher
    Department of Medical Sciences, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 4:e6335. 2009
  10. pmc miRNA in the regulation of skeletal muscle adaptation to acute endurance exercise in C57Bl/6J male mice
    Adeel Safdar
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 4:e5610. 2009

Collaborators

Detail Information

Publications118 found, 100 shown here

  1. ncbi request reprint Mitochondrial myopathies: diagnosis, exercise intolerance, and treatment options
    Mark A Tarnopolsky
    McMaster University Medical Center, Hamilton, Ontario, Canada
    Med Sci Sports Exerc 37:2086-93. 2005
    ..Increased awareness of these disorders by exercise physiologists and sports medicine practitioners should lead to more accurate and more rapid diagnosis and the opportunity for therapy and genetic counseling...
  2. doi request reprint Exercise, sex, menstrual cycle phase, and 17beta-estradiol influence metabolism-related genes in human skeletal muscle
    Ming hua H Fu
    Department of Kinesiology, McMaster University, Hamilton, ON L8S 3Z5, Canada
    Physiol Genomics 40:34-47. 2009
    ..05). Menstrual cycle had a small effect on PPARdelta, GP, and glycogenin mRNA content. Overall, women have greater mRNA content for several genes involved in lipid metabolism, which is partially due to an effect of E(2)...
  3. pmc Eccentric exercise activates novel transcriptional regulation of hypertrophic signaling pathways not affected by hormone changes
    Lauren G MacNeil
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 5:e10695. 2010
    ..02) and FOS at 48H (P<0.05). These findings indicate that early RhoA and NFAT signaling and regulation are altered following exercise for muscle remodeling and repair, but are not affected by E2...
  4. pmc Elevated mitochondrial oxidative stress impairs metabolic adaptations to exercise in skeletal muscle
    Justin D Crane
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 8:e81879. 2013
    ....
  5. pmc Aberrant mitochondrial homeostasis in the skeletal muscle of sedentary older adults
    Adeel Safdar
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 5:e10778. 2010
    ....
  6. pmc Supplementation with α-lipoic acid, CoQ10, and vitamin E augments running performance and mitochondrial function in female mice
    Arkan Abadi
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 8:e60722. 2013
    ..Overall, these results indicate that this antioxidant supplement exerts gender specific effects; augmenting performance and mitochondrial function in untrained females, but does not attenuate training adaptations...
  7. pmc Markers of skeletal muscle mitochondrial function and lipid accumulation are moderately associated with the homeostasis model assessment index of insulin resistance in obese men
    Imtiaz A Samjoo
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 8:e66322. 2013
    ..25; P = 0.152). Our findings suggest that once physical activity and cardiorespiratory fitness have been controlled for, skeletal muscle mitochondrial and IMCL profile in obesity may only partially contribute to the development of IR...
  8. pmc Limb immobilization induces a coordinate down-regulation of mitochondrial and other metabolic pathways in men and women
    Arkan Abadi
    Department of Pediatrics and Medicine, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 4:e6518. 2009
    ....
  9. pmc Sex differences in global mRNA content of human skeletal muscle
    Amy C Maher
    Department of Medical Sciences, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 4:e6335. 2009
    ....
  10. pmc miRNA in the regulation of skeletal muscle adaptation to acute endurance exercise in C57Bl/6J male mice
    Adeel Safdar
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 4:e5610. 2009
    ..We conclude that miRNA-mediated post-transcriptional regulation is potentially involved in the complex regulatory networks that govern skeletal muscle adaptation to endurance exercise in C57Bl/6J male mice...
  11. pmc Impact of treadmill running and sex on hippocampal neurogenesis in the mouse model of amyotrophic lateral sclerosis
    Xiaoxing Ma
    Medical Sciences, McMaster University, Hamilton, Canada
    PLoS ONE 7:e36048. 2012
    ....
  12. ncbi request reprint Evidence for synergistic effects of PRNP and ATP7B mutations in severe neuropsychiatric deterioration
    Nauzer Forbes
    Department of Medicine, McMaster University, Hamilton, Canada
    BMC Med Genet 15:22. 2014
    ..Prion diseases are also rare causes of neuropsychiatric deterioration that can occur sporadically without an identifiable cause, or can be attributed to mutations in the PRNP gene...
  13. doi request reprint Severe infantile leigh syndrome associated with a rare mitochondrial ND6 mutation, m.14487T>C
    Mark Tarnopolsky
    Department of Pediatrics, McMaster University Medical Center, Hamilton, ON, Canada
    Am J Med Genet A 161:2020-3. 2013
    ..This case underscores the importance of considering mitochondrial DNA mutations in families with a negative family history, even in offspring of those who have tested negative for a specific mtDNA mutation...
  14. doi request reprint Endurance training modulates intramyocellular lipid compartmentalization and morphology in skeletal muscle of lean and obese women
    Michaela C Devries
    Departments of Pediatrics and Medicine, McMaster University, Neuromuscular Disease Clinic, Health Sciences Centre, Room 2H26, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    J Clin Endocrinol Metab 98:4852-62. 2013
    ..Endurance training (ET) increases mitochondrial content/activity and IMCL content in young, active men and women. We have previously shown that ET alters the size, number, and physical juxtaposition of IMCLs and mitochondria...
  15. pmc Premature expression of a muscle fibrosis axis in chronic HIV infection
    Rebecca L Kusko
    Boston University School of Medicine, 650 Albany St, EBRC 646, Boston, MA, 02118, USA
    Skelet Muscle 2:10. 2012
    ..abstract:..
  16. pmc Genotype-phenotype correlations in recessive RYR1-related myopathies
    Kimberly Amburgey
    Department of Pediatrics, Taubman Medical Research Institute, University of Michigan Medical Center, 5019 A, Alfred Taubman Biomedical Science Research Building, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    Orphanet J Rare Dis 8:117. 2013
    ..To date, no clear patterns have been identified in these recessive mutations, though no systematic examination has yet been performed...
  17. pmc Myofibrillar protein synthesis following ingestion of soy protein isolate at rest and after resistance exercise in elderly men
    Yifan Yang
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, 1280 Main St, West, Hamilton, ON, Canada, L8S 4K1
    Nutr Metab (Lond) 9:57. 2012
    ..abstract:..
  18. doi request reprint Long-term aerobic exercise is associated with greater muscle strength throughout the life span
    Justin D Crane
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    J Gerontol A Biol Sci Med Sci 68:631-8. 2013
    ..05). In summary, long-term aerobic exercise appears to attenuate age-related reductions in muscle strength in addition to its cardiorespiratory and metabolic benefits...
  19. doi request reprint Exercise testing in metabolic myopathies
    Mark Tarnopolsky
    Department of Pediatrics, McMaster University, Hamilton, ON, Canada
    Phys Med Rehabil Clin N Am 23:173-86, xii. 2012
    ..This article focuses on the usefulness of exercise in the evaluation of genetic metabolic myopathies...
  20. ncbi request reprint Gene expression, fiber type, and strength are similar between left and right legs in older adults
    Mark Tarnopolsky
    McMaster University Medical Center, Pediatrics and Medicine, 1200 Main Street W, Hamilton, Ontario, Canada
    J Gerontol A Biol Sci Med Sci 62:1088-95. 2007
    ..50-fold. None of the mRNA species, or muscle fiber type, size, or strength, was different between legs. These findings are important for the design and analysis of studies using muscle data in older adults...
  21. pmc Creatine monohydrate and conjugated linoleic acid improve strength and body composition following resistance exercise in older adults
    Mark Tarnopolsky
    Department of Pediatrics and Medicine, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 2:e991. 2007
    ..Trial Registration. ClinicalTrials.gov NCT00473902...
  22. doi request reprint Sex differences in exercise metabolism and the role of 17-beta estradiol
    Mark A Tarnopolsky
    Department of Pediatrics and Medicine, McMaster University, Hamilton, Canada
    Med Sci Sports Exerc 40:648-54. 2008
    ..The greater fat oxidation for women during submaximal endurance exercise compared with men seems to occur partly through a sex hormone-mediated enhancement of lipid-oxidation pathways...
  23. doi request reprint Suction-modified Bergström muscle biopsy technique: experience with 13,500 procedures
    Mark A Tarnopolsky
    Department of Pediatrics, McMaster University, 1200 Main Street W, HSC 2H26, Hamilton, Ontario L8N 3Z5, Canada
    Muscle Nerve 43:717-25. 2011
    ..Bergström needle muscle biopsies have been used by exercise physiologists for over 35 years but have been less accepted by neuromuscular clinicians due to size concerns...
  24. ncbi request reprint Influence of endurance exercise training and sex on intramyocellular lipid and mitochondrial ultrastructure, substrate use, and mitochondrial enzyme activity
    Mark A Tarnopolsky
    Department of Pediatrics and Medicine, Rm 2H26, McMaster University Medical Centre, 1200 Main St West, Hamilton, Ontario L8N 3Z5, Canada
    Am J Physiol Regul Integr Comp Physiol 292:R1271-8. 2007
    ..In addition, women have higher IMCL content compared with men due mainly to a greater number of individual droplets. Finally, endurance exercise training increased the proportion of IMCL in physical contact with mitochondria...
  25. pmc Exercising women throw a wrench in the gears of the AMPK-lipid oxidation link
    Mark A Tarnopolsky
    Department of Pediatrics and Medicine, McMaster University, Ontario, Canada
    J Physiol 574:1. 2006
  26. ncbi request reprint What can metabolic myopathies teach us about exercise physiology?
    Mark A Tarnopolsky
    Department of Pediatrics and Medicine, Division of Neurology, McMaster University Medical Centre, Hamilton, ON, Canada
    Appl Physiol Nutr Metab 31:21-30. 2006
    ..In summary, metabolic myopathies provide important insights into regulatory and nutritional aspects of the major biochemical pathways of intermediary metabolism in human skeletal muscle...
  27. doi request reprint The potential benefits of creatine and conjugated linoleic acid as adjuncts to resistance training in older adults
    Mark A Tarnopolsky
    Department of Pediatrics and Medicine, McMaster University, HSC 2H26, 1200 Main St W, Hamilton, ON L8N 3Z5, Canada
    Appl Physiol Nutr Metab 33:213-27. 2008
    ..It will also be important to determine whether these changes are maintained over a longer time period...
  28. doi request reprint The mitochondrial cocktail: rationale for combined nutraceutical therapy in mitochondrial cytopathies
    M A Tarnopolsky
    Department of Pediatrics and Medicine, McMaster University, 1200 Main St W, HSC 2H26, Hamilton, Ontario L8N3Z5, Canada
    Adv Drug Deliv Rev 60:1561-7. 2008
    ....
  29. doi request reprint Nutritional consideration in the aging athlete
    Mark A Tarnopolsky
    Department of Pediatrics, Faculty of Health Science, McMaster University, Hamilton, Ontario, Canada
    Clin J Sport Med 18:531-8. 2008
    ..To evaluate the evidence for dietary recommendations in older adult athletes...
  30. ncbi request reprint Effect of caffeine on the neuromuscular system--potential as an ergogenic aid
    Mark A Tarnopolsky
    Departments of Pediatrics and Medicine, McMaster University, Hamilton, ON L8N3Z5, Canada
    Appl Physiol Nutr Metab 33:1284-9. 2008
    ..In summary, the ergogenic effects of caffeine during endurance activity are mediated partly by enhanced contractile force and partly by a reduction in perceived exertion, possibly though a blunting of effort and (or) pain...
  31. doi request reprint Mitochondrial DNA shifting in older adults following resistance exercise training
    M A Tarnopolsky
    Department of Pediatrics and Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada
    Appl Physiol Nutr Metab 34:348-54. 2009
    ..Preliminary data strongly suggest that mitochondrial DNA shifting occurs in skeletal muscle from older adults following resistance-exercise training...
  32. ncbi request reprint Metabolic myopathies and physical activity: when fatigue is more than simple exertion
    Mark A Tarnopolsky
    Departments of Medicine and Kinesiology, McMaster University Medical Centre, Hamilton, ON, L8N 3Z5, Can
    Phys Sportsmed 30:37-46. 2002
    ..Most patients with metabolic myopathies can participate in sports with appropriate exercise adaptations and dietary manipulation...
  33. doi request reprint Bacterial overgrowth syndrome in myotonic muscular dystrophy is potentially treatable
    Mark A Tarnopolsky
    Department of Pediatrics, McMaster University, 1200 Main Street West, HSC 2H26, Hamilton, Ontario L8N 3Z5, Canada
    Muscle Nerve 42:853-5. 2010
    ....
  34. doi request reprint Caffeine and creatine use in sport
    Mark A Tarnopolsky
    Department of Pediatrics and Medicine, McMaster University, Hamilton, Ont, Canada
    Ann Nutr Metab 57:1-8. 2010
    ..The purpose of this paper is to review the pharmacology and potential mechanism(s) of action of caffeine and creatine as they pertain to possible use as an ergogenic aid in sport...
  35. doi request reprint Creatine as a therapeutic strategy for myopathies
    M A Tarnopolsky
    Department of Pediatrics and Medicine, McMaster University, 1200 Main St West, Hamilton, Ontario, Canada
    Amino Acids 40:1397-407. 2011
    ..e., corticosteroids)...
  36. ncbi request reprint Diagnostic utility of a modified forearm ischemic exercise test and technical issues relevant to exercise testing
    Mark Tarnopolsky
    Department of Neurology, McMaster University Medical Center, Room 4U4, 1200 Main Street W, Hamilton, Ontario L8N 3Z5, Canada
    Muscle Nerve 27:359-66. 2003
    ..Thus, a modified FIT was helpful in the diagnosis of GSD and excluding AMPD deficiency, but not in the diagnosis of MITO disease. Catheter placement is critical to the interpretation of a FIT, whereas pretesting diet is less important...
  37. ncbi request reprint Caffeine potentiates low frequency skeletal muscle force in habitual and nonhabitual caffeine consumers
    M Tarnopolsky
    Department of Neurology and Rehabilitation Medicine and Kinesiology, McMaster University Medical Center, Hamilton, Ontario L8N 3Z5, Canada
    J Appl Physiol (1985) 89:1719-24. 2000
    ..These data support the hypothesis that some of the ergogenic effect of caffeine in endurance exercise performance occurs directly at the skeletal muscle level...
  38. ncbi request reprint Creatine transporter and mitochondrial creatine kinase protein content in myopathies
    M A Tarnopolsky
    Department of Medicine Neurology and Rehabilitation, Room 4U4, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Muscle Nerve 24:682-8. 2001
    ..This further supports the belief that creatine monohydrate supplementation may benefit patients with low muscle creatine stores, although the reduction in creatine transporter protein may have implications for dosing...
  39. ncbi request reprint Gender differences in carbohydrate loading are related to energy intake
    M A Tarnopolsky
    Departments of Medicine Neurology and Rehabilitation, McMaster University, Hamilton, Ontario L8N 3Z5
    J Appl Physiol (1985) 91:225-30. 2001
    ..05). There were no gender differences in the proportion of pro- and macroglycogen or hexokinase activity. A low energy intake may explain the previously reported lower capacity for women to glycogen load compared with men...
  40. ncbi request reprint Creatine-dextrose and protein-dextrose induce similar strength gains during training
    M A Tarnopolsky
    Department of Medicine Neurology and Neurological Rehabilitation, Rm 4U4, McMaster University Medical Center, 1200 Main Street W, Hamilton, Ontario, Canada, L8N 3Z5
    Med Sci Sports Exerc 33:2044-52. 2001
    ..We have recently shown that timing of nutrient delivery in the postexercise period can have positive effects on whole body protein turnover (B. D. Roy et al., Med Sci Sports Exerc. 32(8):1412-1418, 2000)...
  41. ncbi request reprint Protein requirements for endurance athletes
    Mark Tarnopolsky
    Department of Pediatrics and Medicine, McMaster University, Hamilton, Ontario, Canada
    Nutrition 20:662-8. 2004
    ..6 gPRO/kg/d. Although most endurance athletes get enough protein to support any increased requirements, those with low energy or carbohydrate intakes may require nutritional advice to optimize dietary protein intake...
  42. pmc Myoadenylate deaminase deficiency does not affect muscle anaplerosis during exhaustive exercise in humans
    M A Tarnopolsky
    Department of Medicine and Kinesiology, McMaster University, Hamilton, Ontario, Canada
    J Physiol 533:881-9. 2001
    ..4. In summary, complete and partial muscle AMPD deficiency did not affect TCA cycle anaplerosis, phosphocreatine hydrolysis, energy charge or exercise performance...
  43. ncbi request reprint Attenuation of free radical production and paracrystalline inclusions by creatine supplementation in a patient with a novel cytochrome b mutation
    Mark A Tarnopolsky
    Department of Medicine, McMaster University Medical Center, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Muscle Nerve 29:537-47. 2004
    ..The results suggest that the development of exercise-induced paracrystalline inclusions may be influenced by the G15497A mtDNA mutation, and that CM mitigates against the pathological consequences of this mutation...
  44. ncbi request reprint Novel SCO2 mutation (G1521A) presenting as a spinal muscular atrophy type I phenotype
    Mark A Tarnopolsky
    Department of Neurology, McMaster University, Hamilton, Ontario, Canada
    Am J Med Genet A 125:310-4. 2004
    ..SCO2 mutations should be screened in suspected SMA cases with normal smn mutation analysis and any one of; cardiomyopathy, lactic acidosis, or COX deficiency in muscle...
  45. ncbi request reprint Clinical variability in maternally inherited leber hereditary optic neuropathy with the G14459A mutation
    Mark A Tarnopolsky
    Department of Neurology, 4U4, McMaster University, 1200 Main Street W, Hamilton, Ontario, Canada L8N 3Z5
    Am J Med Genet A 124:372-6. 2004
    ..The male patient in the second pedigree showed features of optic neuropathy without spasticity/dystonia. These results further support that the 14,459 G --> A transition mutation is causally related to LHON and spasticity/dystonia...
  46. ncbi request reprint Creatine monohydrate supplementation does not increase muscle strength, lean body mass, or muscle phosphocreatine in patients with myotonic dystrophy type 1
    Mark Tarnopolsky
    Department of Medicine Neurology and Rehabilitation, McMaster University, Hamilton, Canada
    Muscle Nerve 29:51-8. 2004
    ....
  47. ncbi request reprint Histological assessment of intermediate- and long-term creatine monohydrate supplementation in mice and rats
    M A Tarnopolsky
    Department of Pediatrics and Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    Am J Physiol Regul Integr Comp Physiol 285:R762-9. 2003
    ..Species differences must be considered in the evaluation of toxicological and physiological studies...
  48. ncbi request reprint Acute and moderate-term creatine monohydrate supplementation does not affect creatine transporter mRNA or protein content in either young or elderly humans
    Mark Tarnopolsky
    Department of Medicine Neurology and Rehabilitation, McMaster University, Hamilton, ON, Canada
    Mol Cell Biochem 244:159-66. 2003
    ..05). These results demonstrated that Cr-mH supplementation during weight training resulted in increases in skeletal muscle total creatine without reductions in CRT protein and acute Cr-mH loading did not decrease CRT mRNA content...
  49. ncbi request reprint Creatine monohydrate increases strength in patients with neuromuscular disease
    M Tarnopolsky
    Department of Neurology Neurological Rehabilitation and Kinesiology, McMaster University Medical Center, Hamilton, Ontario, Canada
    Neurology 52:854-7. 1999
    ..Creatine administration increased all measured indices in both studies. Short-term creatine monohydrate increased high-intensity strength significantly in patients with neuromuscular disease...
  50. ncbi request reprint Postexercise protein-carbohydrate and carbohydrate supplements increase muscle glycogen in men and women
    M A Tarnopolsky
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    J Appl Physiol (1985) 83:1877-83. 1997
    ..5 mmol . kg dry muscle-1 . h-1; P < 0.001) with no gender differences. We conclude that postexercise CHO and CHO-Pro-Fat nutritional supplements can increase glycogen resynthesis to a greater extent than Pl for both men and women...
  51. ncbi request reprint Creatine monohydrate enhances strength and body composition in Duchenne muscular dystrophy
    M A Tarnopolsky
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Neurology 62:1771-7. 2004
    ..To determine whether creatine monohydrate (CrM) supplementation increases strength and fat-free mass (FFM) in boys with Duchenne muscular dystrophy (DD)...
  52. doi request reprint Carbohydrate feeding during recovery alters the skeletal muscle metabolic response to repeated sessions of high-intensity interval exercise in humans
    Andrew J R Cochran
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, ON L8S 4K1, Canada
    J Appl Physiol (1985) 108:628-36. 2010
    ....
  53. ncbi request reprint Antioxidant enzyme activity is up-regulated after unilateral resistance exercise training in older adults
    Gianni Parise
    Department of Kinesiology, McMaster University, 1200 Main Street West, Hamilton, ON, L8N 3Z5, Canada
    Free Radic Biol Med 39:289-95. 2005
    ..In conclusion, unilateral resistance exercise training is effective in enhancing the skeletal muscle cellular antioxidant capacity in older adults. The potential long-term benefits of these adaptations remain to be evaluated...
  54. pmc A practical model of low-volume high-intensity interval training induces mitochondrial biogenesis in human skeletal muscle: potential mechanisms
    Jonathan P Little
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    J Physiol 588:1011-22. 2010
    ..The results also suggest that increases in SIRT1, nuclear PGC-1alpha, and Tfam may be involved in coordinating mitochondrial adaptations in response to HIT in human skeletal muscle...
  55. doi request reprint Resistance exercise decreases eIF2Bepsilon phosphorylation and potentiates the feeding-induced stimulation of p70S6K1 and rpS6 in young men
    Elisa I Glover
    Department of Kinesiology, Exercise Metabolism Research Group, McMaster University, 1280 Main St West, Hamilton, ON, Canada L8S 4K1
    Am J Physiol Regul Integr Comp Physiol 295:R604-10. 2008
    ..We conclude that resistance exercise potentiates the effect of feeding on the phosphorylation and presumably activation of critical proteins involved in the regulation of muscle protein synthesis in young men...
  56. ncbi request reprint The influence of post-exercise macronutrient intake on energy balance and protein metabolism in active females participating in endurance training
    Brian D Roy
    Departments of Medicine and Kinesiology, McMaster University, Hamilton, ON, Canada L8N 3Z5
    Int J Sport Nutr Exerc Metab 12:172-88. 2002
    ..Importantly, post-exercise supplementation improved time to exhaustion during a subsequent bout of endurance exercise...
  57. ncbi request reprint Treadmill training-induced adaptations in muscle phenotype in persons with incomplete spinal cord injury
    Brian G Stewart
    Department of Kinesiology, McMaster University, 1280 Main Street W, Hamilton, Ontario L8S 4K1, Canada
    Muscle Nerve 30:61-8. 2004
    ..In addition, BWST training can bring about improvements in ambulatory capacity and antiatherogenic changes in blood lipid profile...
  58. ncbi request reprint Understanding skeletal muscle adaptation to exercise training in humans: contributions from microarray studies
    Douglas J Mahoney
    Apoptosis Research Center, Children s Hospital of Eastern Ontario Research Institute, Room 3121, 401 Smyth Road, Ottawa, Ontario, Canada, K1H 8L1
    Phys Med Rehabil Clin N Am 16:859-73, vii. 2005
  59. doi request reprint The effect of aging on human skeletal muscle mitochondrial and intramyocellular lipid ultrastructure
    Justin D Crane
    Department of Pediatrics and Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    J Gerontol A Biol Sci Med Sci 65:119-28. 2010
    ..These factors likely contribute to age-related reductions in mitochondrial function and lipid metabolism...
  60. doi request reprint Muscle physiology in healthy men and women and those with metabolic myopathies
    Michaela C Devries
    Pediatrics and Medicine, Division of Neurology, McMaster University, McMaster University Medical Center, 1200 Main Street West, Hamilton, ON, Canada L8N 3Z5
    Neurol Clin 26:115-48; ix. 2008
    ..This article gives an overview of these different impacts on endurance exercise, concluding with an examination of the metabolic myopathies that impair substrate metabolism in skeletal muscle and result in exercise intolerance...
  61. ncbi request reprint Creatine supplementation enhances isometric strength and body composition improvements following strength exercise training in older adults
    Andrea Brose
    Department of Kinesiology, McMaster University, Ontario, Canada
    J Gerontol A Biol Sci Med Sci 58:11-9. 2003
    ..The addition of CrM supplementation to the exercise stimulus enhanced the increase in total and fat-free mass, and gains in several indices of isometric muscle strength...
  62. ncbi request reprint Short-term training attenuates muscle TCA cycle expansion during exercise in women
    Kristen D Dawson
    Department of Kinesiology, McMaster University, Hamilton, ON, Canada L8S 4K1
    J Appl Physiol 95:999-1004. 2003
    ..05). We conclude that 1). the contraction-induced increase in flux through AAT is reduced after 5 days of aerobic training and 2). the muscle glycogenolytic response during exercise after STT in women is similar to that in men...
  63. doi request reprint Muscle metabolism during exercise with carbohydrate or protein-carbohydrate ingestion
    Naomi M Cermak
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Ontario, Canada
    Med Sci Sports Exerc 41:2158-64. 2009
    ....
  64. ncbi request reprint IMCL area density, but not IMCL utilization, is higher in women during moderate-intensity endurance exercise, compared with men
    Michaela C Devries
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 293:R2336-42. 2007
    ..Endurance exercise resulted in a net decrease in IMCL density due to decreased number of IMCL, not decreased IMCL size, in both sexes...
  65. ncbi request reprint Effects of a CRF2R agonist and exercise on mdx and wildtype skeletal muscle
    Julie E Hall
    Department of Pediatrics, Rm 2H18, McMaster University Medical Center, 1200 Main Street W, Hamilton, Ontario L8N 3Z5, Canada
    Muscle Nerve 36:336-41. 2007
    ..CRF2R-treated mice had decreased heart weights compared to placebo-treated mice. We conclude that CRF2R agonists should be further evaluated as a potential therapy for dystrophinopathies...
  66. doi request reprint A randomized trial of coenzyme Q10 in mitochondrial disorders
    Elisa I Glover
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    Muscle Nerve 42:739-48. 2010
    ..05). Sixty days of moderate- to high-dose CoQ(10) treatment had minor effects on cycle exercise aerobic capacity and post-exercise lactate but did not affect other clinically relevant variables such as strength or resting lactate...
  67. ncbi request reprint Clinical use of creatine in neuromuscular and neurometabolic disorders
    Mark A Tarnopolsky
    Department of Pediatrics and Medicine Neurology and Rehabilitation, Neuromuscular and Neurometabolic Clinic, Rm 2H26, McMaster University Medical Center, 1200 Main St W, Hamilton, Ontario, Canada, L8N 3Z5
    Subcell Biochem 46:183-204. 2007
    ....
  68. ncbi request reprint Nutritional therapy improves function and complements corticosteroid intervention in mdx mice
    Eric T Payne
    Department of Pediatrics, McMaster University Medical Center, 1200 Main Street W, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Muscle Nerve 33:66-77. 2006
    ..01), and smaller retroperitoneal fat pad stores (P < 0.001). This study provided evidence for therapeutic benefit from a four-compound combination therapy alone, and in conjunction with corticosteroids in the mdx model of DMD...
  69. doi request reprint Identification of ataxia-associated mtDNA mutations (m.4052T>C and m.9035T>C) and evaluation of their pathogenicity in transmitochondrial cybrids
    Marianna Sikorska
    Neurogenesis and Brain Repair Group M54, Institute for Biological Sciences, National Research Council Canada, 1200 Montreal Road, Ottawa, Ontario, K1A 0R6, Canada
    Muscle Nerve 40:381-94. 2009
    ..Furthermore, antioxidant therapy might prove helpful in the management of this disease...
  70. doi request reprint Endurance training without weight loss lowers systemic, but not muscle, oxidative stress with no effect on inflammation in lean and obese women
    Michaela C Devries
    Department of Pediatrics, McMaster University, Hamilton, ON, Canada
    Free Radic Biol Med 45:503-11. 2008
    ..02) in all subjects and CuZnSOD protein content (P=0.04) in obese women, in the absence of changes in body weight or composition. ET without weight loss decreases systemic oxidative stress, but not markers of inflammation, in obese women...
  71. ncbi request reprint Consumption of fat-free fluid milk after resistance exercise promotes greater lean mass accretion than does consumption of soy or carbohydrate in young, novice, male weightlifters
    Joseph W Hartman
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, ON, Canada
    Am J Clin Nutr 86:373-81. 2007
    ..Acute consumption of fat-free fluid milk after resistance exercise promotes a greater positive protein balance than does soy protein...
  72. ncbi request reprint Oxidative stress and antioxidant enzyme upregulation in SOD1-G93A mouse skeletal muscle
    Douglas J Mahoney
    Department of Medical Sciences, McMaster University, Hamilton, Ontario, Canada
    Muscle Nerve 33:809-16. 2006
    ..5-fold, respectively). Taken together, our data demonstrate oxidative stress and compensatory antioxidant enzyme upregulation in SOD1-G93A skeletal muscle...
  73. ncbi request reprint Sex-based differences in skeletal muscle function and morphology with short-term limb immobilization
    Nobuo Yasuda
    Dept of Kinesiology, McMaster Univ, Hamilton, Ontario, Canada
    J Appl Physiol 99:1085-92. 2005
    ..Furthermore, we have described an effective and safe knee immobilization method that results in reductions in quadriceps muscle strength and size...
  74. doi request reprint Men supplemented with 17beta-estradiol have increased beta-oxidation capacity in skeletal muscle
    Amy C Maher
    Department of Medical Science, McMaster University, Hamilton, Ontario, Canada
    Physiol Genomics 42:342-7. 2010
    ..05). In conclusion, E(2) might partially regulate lipid metabolism in skeletal muscle by altering the protein content of MCAD, which may be directly or indirectly regulated by an increase in PGC-1alpha and reduction in miR-29b...
  75. ncbi request reprint Menstrual cycle phase and sex influence muscle glycogen utilization and glucose turnover during moderate-intensity endurance exercise
    Michaela C Devries
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    Am J Physiol Regul Integr Comp Physiol 291:R1120-8. 2006
    ..001) and a greater PG utilization (P = 0.05) compared with LP women. We conclude that sex, and to a lesser extent menstrual cycle, influence glucose turnover and glycogen utilization during moderate-intensity endurance exercise...
  76. pmc Psychiatric symptoms correlate with metabolic indices in the hippocampus and cingulate in patients with mitochondrial disorders
    R E Anglin
    Department of Psychiatry and Behavioural Neurosciences and Medicine, McMaster University, Hamilton, Ontario, Canada
    Transl Psychiatry 2:e187. 2012
    ..In particular, they suggest that metabolic processes in the hippocampus may have an important role in the neurobiology of anxiety...
  77. ncbi request reprint Quantification of subcellular glycogen in resting human muscle: granule size, number, and location
    I Marchand
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, N1G 2W1, Ontario, Canada
    J Appl Physiol 93:1598-607. 2002
    ..These results demonstrate a compartmentalized pattern of subcellular G deposition in human skeletal muscle for both the size and density of granules...
  78. ncbi request reprint Contraction-induced muscle damage is unaffected by vitamin E supplementation
    Louise J Beaton
    Department of Kinesiology, McMaster University, Hamilton, ON, L8S 4K1, Canada
    Med Sci Sports Exerc 34:798-805. 2002
    ..The present study sought to determine the effect of vitamin E supplementation on indices of exercise-induced muscle damage and the postexercise inflammatory response after performance of repeated eccentric muscle contractions...
  79. doi request reprint Acute endurance exercise increases the nuclear abundance of PGC-1alpha in trained human skeletal muscle
    Jonathan P Little
    Department of Kinesiology, McMaster University, Ivor Wynne Centre, Hamilton, ON L8S 4K1
    Am J Physiol Regul Integr Comp Physiol 298:R912-7. 2010
    ....
  80. ncbi request reprint Sex-based effects on the distribution of NK cell subsets in response to exercise and carbohydrate intake in adolescents
    Brian W Timmons
    Children s Exercise and Nutritional Centre, McMaster University Medical Center, Hamilton, Ontario, Canada L8N 3Z5
    J Appl Physiol 100:1513-9. 2006
    ..These results demonstrate sex-based differences in the distribution of NK cell subsets and activation status in response to exercise, but not CHO intake, and further support the need to control for sex in exercise immunology studies...
  81. ncbi request reprint Low expression of long-chain acyl-CoA dehydrogenase in human skeletal muscle
    Amy C Maher
    Department of Medical Science, McMaster University, Ontario, Canada
    Mol Genet Metab 100:163-7. 2010
    ..The purpose of this study was to investigate the expression levels of LCAD in human skeletal muscle...
  82. doi request reprint Little change in markers of protein breakdown and oxidative stress in humans in immobilization-induced skeletal muscle atrophy
    Elisa I Glover
    Department of Kinesiology Exercise Metabolic Research Group, McMaster University, Hamilton, Ontario, Canada
    Appl Physiol Nutr Metab 35:125-33. 2010
    ....
  83. ncbi request reprint Oxidative stress and the mitochondrial theory of aging in human skeletal muscle
    Parise Gianni
    Department of Kinesiology, McMaster University, Hamilton, Ont, Canada
    Exp Gerontol 39:1391-400. 2004
    ..In conclusion, healthy aging is associated with oxidative damage to proteins and DNA, a compensatory up-regulation of antioxidant enzymes, and aberrations of mtDNA, with no reduction in electron transport chain maximal enzyme activity...
  84. pmc Women have higher protein content of beta-oxidation enzymes in skeletal muscle than men
    Amy C Maher
    Department of Medical Science, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 5:e12025. 2010
    ..In conclusion, women have more protein content of the major enzymes involved in long and medium chain fatty acid oxidation which could account for the observed differences in fat oxidation during exercise...
  85. ncbi request reprint Resistance exercise training decreases oxidative damage to DNA and increases cytochrome oxidase activity in older adults
    Gianni Parise
    Department of Kinesiology, McMaster University, Hamilton, Ont, Canada L8N 3Z5
    Exp Gerontol 40:173-80. 2005
    ..Moreover, increases in complex IV of the electron transport chain may have an indirect antioxidant effect in older adults and may improve function in daily activities...
  86. pmc Short-term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance
    Martin J Gibala
    Department of Kinesiology IWC AB122, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada
    J Physiol 575:901-11. 2006
    ..05). Given the large difference in training volume, these data demonstrate that SIT is a time-efficient strategy to induce rapid adaptations in skeletal muscle and exercise performance that are comparable to ET in young active men...
  87. pmc The effect of body weight-supported treadmill training on muscle morphology in an individual with chronic, motor-complete spinal cord injury: A case study
    Melanie M Adams
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    J Spinal Cord Med 29:167-71. 2006
    ....
  88. ncbi request reprint Patients with dystrophinopathy show evidence of increased oxidative stress
    M Christine Rodriguez
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    Free Radic Biol Med 34:1217-20. 2003
    ..01) but not myotonic dystrophy, as compared to healthy controls. These results indicate that 8-OHdG excretion can be used as a marker of oxidative stress in clinical trials with dystrophinopathy...
  89. ncbi request reprint Sporadic rippling muscle disease unmasked by simvastatin
    Steven K Baker
    Department of Medicine, Neuromuscular Disease Clinic, Room 2H22, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Muscle Nerve 34:478-81. 2006
    ..We postulate that an immune-mediated disruption of caveolar function was exacerbated by statin exposure. We are unaware of any previous cases of statin-mediated unmasking of RMD...
  90. doi request reprint Effect of endurance exercise on hepatic lipid content, enzymes, and adiposity in men and women
    Michaela C Devries
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    Obesity (Silver Spring) 16:2281-8. 2008
    ..405, P = 0.003). Short-term endurance training without weight loss does not alter hepatic lipid content. There was a strong relationship between GGT/ALT and body composition (percent BF) as well as between ALT and hepatic lipid content...
  91. doi request reprint Two methods for determining plasma IL-6 in humans at rest and following exercise
    Brian W Timmons
    Children s Exercise and Nutrition Centre, McMaster University, Chedoke Hospital, Evel Bldg, Sanatorium Road, Hamilton, ON, L8N 3Z5, Canada
    Eur J Appl Physiol 105:13-8. 2009
    ..0001), but exhibited poor agreement (mean bias +/- 1SD = -1.4 +/- 2.1 pg/mL). The CBA provided concordant IL-6 concentrations at rest, when detected, but underestimated exercise-induced increases in IL-6 versus the ELISA method...
  92. ncbi request reprint Nutritional and exercise-based therapies in the treatment of mitochondrial disease
    Douglas J Mahoney
    Department of Medical Sciences, McMaster University, Hamilton, Ontario, Canada
    Curr Opin Clin Nutr Metab Care 5:619-29. 2002
    ....
  93. pmc Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle
    Sarah B Wilkinson
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1
    J Physiol 586:3701-17. 2008
    ....
  94. ncbi request reprint Body-weight-support treadmill training improves blood glucose regulation in persons with incomplete spinal cord injury
    Stuart M Phillips
    Department of Kinesiology, Exercise and Metabolism Research Group, Centre for Health Promotion and Rehabilitation, McMaster University, 1280 Main St West, Hamilton, ON, Canada L8S 4K1
    J Appl Physiol (1985) 97:716-24. 2004
    ..Increases in the capacity for transport and phosphorylation glucose in skeletal muscle likely play a role in these adaptations...
  95. ncbi request reprint Estrogen supplementation reduces whole body leucine and carbohydrate oxidation and increases lipid oxidation in men during endurance exercise
    Mazen J Hamadeh
    Department of Pediatrics and Medicine, McMaster University Medical Center, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    J Clin Endocrinol Metab 90:3592-9. 2005
    ....
  96. ncbi request reprint Low intensity training decreases markers of oxidative stress in skeletal muscle of mdx mice
    Jan J Kaczor
    Department of Pediatrics, McMaster University Medical Center, 1200 Main St W, Hamilton, Ontario, Canada L8N 3Z5
    Free Radic Biol Med 43:145-54. 2007
    ..These results are of relevance for therapeutic exercise in patients with dystrophinopathy where exercise prescription remains controversial...
  97. ncbi request reprint Transgenerational effects of fetal and neonatal exposure to nicotine
    Alison C Holloway
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, RM HSC 3N52, 1200 Main Street West, Hamilton, ON, Canada
    Endocrine 31:254-9. 2007
    ..The offspring of nicotine-exposed mothers also had elevated blood pressure. These data demonstrate that adverse effects of fetal and neonatal exposure to nicotine can influence aspects of metabolic risk in subsequent generations...
  98. ncbi request reprint The effect of aging on anaerobic and aerobic enzyme activities in human skeletal muscle
    Jan J Kaczor
    Department of Biochemistry, J Sniadecki Academy of Physical Education and Sport, Gdansk, Poland
    J Gerontol A Biol Sci Med Sci 61:339-44. 2006
    ..001). In conclusion, some of the reduction in muscle performance in older adults may be due to lower activity of the anaerobic and aerobic enzymes as well as protein content, not solely due to a decrease in physical activity...
  99. pmc Caloric restriction shortens lifespan through an increase in lipid peroxidation, inflammation and apoptosis in the G93A mouse, an animal model of ALS
    Barkha P Patel
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    PLoS ONE 5:e9386. 2010
    ..Catalase, Bcl-2 and caspases did not differ. We conclude that CR increases lipid peroxidation, inflammation and apoptosis, while decreasing mitochondrial bioenergetic efficiency, protein oxidation and stress response in G93A mice...
  100. doi request reprint Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men
    Daniel R Moore
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Canada
    Am J Clin Nutr 89:161-8. 2009
    ..The anabolic effect of resistance exercise is enhanced by the provision of dietary protein...