H Szechtman

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint Spatial learning during the course of autoimmune disease in MRL mice
    B Sakic
    Department of Biomedical Sciences, McMaster University, Hamilton, Ont, Canada
    Behav Brain Res 54:57-66. 1993
  2. pmc When too much is not enough: obsessive-compulsive disorder as a pathology of stopping, rather than starting
    Andrea L Hinds
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 7:e30586. 2012
  3. pmc Compulsive checking behavior of quinpirole-sensitized rats as an animal model of Obsessive-Compulsive Disorder(OCD): form and control
    H Szechtman
    Dept of Psychiatry and Behavioural Neurosciences, McMaster University, Canada
    BMC Neurosci 2:4. 2001
  4. ncbi request reprint Obsessive-compulsive disorder as a disturbance of security motivation: constraints on comorbidity
    H Szechtman
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    Neurotox Res 10:103-12. 2006
  5. ncbi request reprint Obsessive-compulsive disorder as a disturbance of security motivation
    Henry Szechtman
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    Psychol Rev 111:111-27. 2004
  6. doi request reprint Effects of salvinorin A on locomotor sensitization to D2/D3 dopamine agonist quinpirole
    Pieter Beerepoot
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada
    Neurosci Lett 446:101-4. 2008
  7. ncbi request reprint Kappa-opioid agonist U69593 potentiates locomotor sensitization to the D2/D3 agonist quinpirole: pre- and postsynaptic mechanisms
    Melissa L Perreault
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    Neuropsychopharmacology 31:1967-81. 2006
  8. ncbi request reprint Kappa-opioid receptor stimulation quickens pathogenesis of compulsive checking in the quinpirole sensitization model of obsessive-compulsive disorder (OCD)
    Melissa L Perreault
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    Behav Neurosci 121:976-91. 2007
  9. ncbi request reprint Quinpirole induces compulsive checking behavior in rats: a potential animal model of obsessive-compulsive disorder (OCD)
    H Szechtman
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Behav Neurosci 112:1475-85. 1998
  10. ncbi request reprint Clorgyline-induced switch from locomotion to mouthing in sensitization to the dopamine D2/D3 agonist quinpirole in rats: role of sigma and imidazoline I2 receptors
    Kirsten E Culver
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Health Science Center, Room 4N82, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Psychopharmacology (Berl) 167:211-8. 2003

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Spatial learning during the course of autoimmune disease in MRL mice
    B Sakic
    Department of Biomedical Sciences, McMaster University, Hamilton, Ont, Canada
    Behav Brain Res 54:57-66. 1993
    ....
  2. pmc When too much is not enough: obsessive-compulsive disorder as a pathology of stopping, rather than starting
    Andrea L Hinds
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 7:e30586. 2012
    ....
  3. pmc Compulsive checking behavior of quinpirole-sensitized rats as an animal model of Obsessive-Compulsive Disorder(OCD): form and control
    H Szechtman
    Dept of Psychiatry and Behavioural Neurosciences, McMaster University, Canada
    BMC Neurosci 2:4. 2001
    ..For this purpose, the rat's home-cage was placed into the open field at the beginning or the middle of a 2-hr test...
  4. ncbi request reprint Obsessive-compulsive disorder as a disturbance of security motivation: constraints on comorbidity
    H Szechtman
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    Neurotox Res 10:103-12. 2006
    ....
  5. ncbi request reprint Obsessive-compulsive disorder as a disturbance of security motivation
    Henry Szechtman
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    Psychol Rev 111:111-27. 2004
    ..The proposed model integrates many previous disparate observations and concepts about OCD and embeds it within the broader understanding of normal motivation...
  6. doi request reprint Effects of salvinorin A on locomotor sensitization to D2/D3 dopamine agonist quinpirole
    Pieter Beerepoot
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada
    Neurosci Lett 446:101-4. 2008
    ..Moreover, the opposite effects of high and low salvinorin A doses suggest that salvinorin A can produce bidirectional modulation of sensitization to dopamine agonists...
  7. ncbi request reprint Kappa-opioid agonist U69593 potentiates locomotor sensitization to the D2/D3 agonist quinpirole: pre- and postsynaptic mechanisms
    Melissa L Perreault
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    Neuropsychopharmacology 31:1967-81. 2006
    ..Together, findings suggest that sensitization to QNP is not a unitary phenomenon but has components that are relatively independent, mediated by distinct pre- and postsynaptic mechanisms and modulated by kappa receptor activity...
  8. ncbi request reprint Kappa-opioid receptor stimulation quickens pathogenesis of compulsive checking in the quinpirole sensitization model of obsessive-compulsive disorder (OCD)
    Melissa L Perreault
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    Behav Neurosci 121:976-91. 2007
    ..The animal model findings point to a potential role of kappa opioid systems in hastening the pathogenesis of OCD and to the possibility that distinct brain regions may mediate the development and the expression of compulsive checking...
  9. ncbi request reprint Quinpirole induces compulsive checking behavior in rats: a potential animal model of obsessive-compulsive disorder (OCD)
    H Szechtman
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Behav Neurosci 112:1475-85. 1998
    ..Quinpirole-induced compulsive checking may be an exaggeration of normal checking of home site in rats. Results suggest an animal model of obsessive-compulsive disorder and a role for dopamine in this disorder...
  10. ncbi request reprint Clorgyline-induced switch from locomotion to mouthing in sensitization to the dopamine D2/D3 agonist quinpirole in rats: role of sigma and imidazoline I2 receptors
    Kirsten E Culver
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Health Science Center, Room 4N82, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Psychopharmacology (Berl) 167:211-8. 2003
    ..Clorgyline has a high affinity for imidazoline I(2) and sigma receptors, which could account for its effects on quinpirole sensitization...
  11. pmc Altered dopamine D2-like receptor binding in rats with behavioral sensitization to quinpirole: effects of pre-treatment with Ro 41-1049
    Kirsten E Culver
    School of Nursing, McMaster University, Hamilton, Ontario, Canada
    Eur J Pharmacol 592:67-72. 2008
    ....
  12. ncbi request reprint D2 receptor blockade in the dorsal raphe increases quinpirole-induced locomotor excitation
    Karen K Szumlinski
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1200 Main St West, Hamilton, Ontario, Canada L8N 3Z5
    Neuroreport 13:563-6. 2002
    ..These data suggest that D2 receptor activation in the DRN suppresses QNP-induced locomotor excitation, an effect that may be related to D2 receptor-mediated alterations in serotonin transmission...
  13. ncbi request reprint Progressive atrophy of pyramidal neuron dendrites in autoimmune MRL-lpr mice
    B Sakic
    Department of Psychiatry, McMaster University, Hamilton, Ontario, Canada
    J Neuroimmunol 87:162-70. 1998
    ..Reduced dendritic complexity may represent, at least in part, a structural basis for the altered behavioral profile of MRL-lpr mice...
  14. ncbi request reprint Immunosuppression prevents neuronal atrophy in lupus-prone mice: evidence for brain damage induced by autoimmune disease?
    B Sakic
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1200 Main St West, Hamilton, Ontario, Canada
    J Neuroimmunol 111:93-101. 2000
    ....
  15. ncbi request reprint Increased TUNEL staining in brains of autoimmune Fas-deficient mice
    B Sakic
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, HSC 4N77A, 1200 Main Street, Hamilton, Ontario, Canada
    J Neuroimmunol 104:147-54. 2000
    ....
  16. ncbi request reprint Reduced corticotropin-releasing factor and enhanced vasopressin gene expression in brains of mice with autoimmunity-induced behavioral dysfunction
    B Sakic
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Neuroimmunol 96:80-91. 1999
    ..Furthermore, they support the parallel between chronic stress and chronic autoimmunity/inflammation, and suggest common central mechanisms relevant to endocrine function and behavior...
  17. pmc Where the imaginal appears real: a positron emission tomography study of auditory hallucinations
    H Szechtman
    Department of Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Proc Natl Acad Sci U S A 95:1956-60. 1998
    ..Inappropriate activation of the right anterior cingulate may lead self-generated thoughts to be experienced as external, producing spontaneous auditory hallucinations...
  18. pmc Knots: attractive places with high path tortuosity in mouse open field exploration
    Anna Dvorkin
    Department of Zoology, Tel Aviv University, Tel Aviv, Israel
    PLoS Comput Biol 6:e1000638. 2010
    ..The rich vestibular input generated by scribbling could improve the interpretation of the visual scene...
  19. ncbi request reprint Motion in response to the hypnotic suggestion of arm rigidity: a window on underlying mechanisms
    Victoria Galea
    School of Rehabilitation Science, Institute of Applied Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Int J Clin Exp Hypn 58:251-68. 2010
    ..The lack of a motor strategy is more consistent with dissociated-control theory, whereas the trembling response is more consistent with social-cognitive and dissociated-experience theories...
  20. ncbi request reprint Cotreatment with the kappa opioid agonist U69593 enhances locomotor sensitization to the D2/D3 dopamine agonist quinpirole and alters dopamine D2 receptor and prodynorphin mRNA expression in rats
    Melissa L Perreault
    Department of Psychiatry and Behavioural Neurosciences, Health Science Centre, Room 4N7, McMaster University, Hamilton, ON, Canada
    Psychopharmacology (Berl) 194:485-96. 2007
    ..Behavioral evidence has implicated both pre- and postsynaptic changes as being involved in this augmentation...
  21. ncbi request reprint A PET provocation study of generalized social phobia
    Michael Van Ameringen
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada L8N 3Z5
    Psychiatry Res 132:13-8. 2004
    ..Deactivation of these regions may reflect a strategy of visual avoidance employed by the patients to dampen their phobic experience...
  22. ncbi request reprint Sex differences in functional activation patterns revealed by increased emotion processing demands
    Geoffrey B C Hall
    The Brain Body Institute, St Joseph s Healthcare Hamilton, McMaster University, 314 Martha Wing, St Joseph s Healthcare Hamilton, 50 Charlton Ave E, Hamilton, Ontario L8N 4A6
    Neuroreport 15:219-23. 2004
    ..These results suggest that when processing broader cross-modal emotional stimuli, men engage more in associative cognitive strategies while women draw more on primary emotional references...
  23. ncbi request reprint Hypophysectomy does not block sensitization to the dopamine agonist quinpirole or its modulation by the MAOI clorgyline
    Kirsten E Culver
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    Horm Behav 45:23-30. 2004
    ....
  24. ncbi request reprint Enhanced salience and emotion recognition in Autism: a PET study
    Geoffrey B C Hall
    Brain Body Institute, St Joseph s Healthcare Hamilton, Ontario, Canada
    Am J Psychiatry 160:1439-41. 2003
    ..This study examined neural activation of facial stimuli in autism when the salience of emotional cues was increased by prosodic information...
  25. ncbi request reprint Altered neurotransmission in brains of autoimmune mice: pharmacological and neurochemical evidence
    Boris Sakic
    The Brain Body Institute, McMaster University, Rm H305, Father Sean O Sullivan Research Center, St Joseph s Healthcare, 50 Charlton Avenue East, L8N 4A6, Hamilton, Ontario, Canada
    J Neuroimmunol 129:84-96. 2002
    ..These results are consistent with the hypothesis that imbalanced neurotransmitter regulation of the hypothalamus-pituitary axis plays an important role in the etiology of behavioral dysfunction induced by systemic autoimmune disease...
  26. ncbi request reprint Association of altered whole-body metabolism with locomotor sensitization induced by quinpirole
    D V Coscina
    Department of Psychology, University of Toronto, Ontario, Canada
    Physiol Behav 63:755-61. 1998
    ..This suggests that enhanced utilization of body lipids could be a separate physiological consequence of quinpirole that might support in part the heightened locomotor activity characteristic of the behavioral sensitization it induces...
  27. ncbi request reprint Monoamine oxidase inhibitor-induced blockade of locomotor sensitization to quinpirole: role of striatal dopamine uptake inhibition
    K E Culver
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, L8N 3Z5, Ontario, Canada
    Neuropharmacology 43:385-93. 2002
    ....
  28. ncbi request reprint Immunosuppressive treatment prevents behavioral deficit in autoimmune MRL-lpr mice
    B Sakic
    Department of Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
    Physiol Behav 58:797-802. 1995
    ..The effect of cyclophosphamide in the MRL-lpr group is believed to reflect the suppression of pathogenic immune factor(s) that alter behavior during the onset of autoimmune disease...
  29. ncbi request reprint Asymmetric modulation of a catecholamine-regulated protein in the rat brain, following quinpirole administration
    Joseph Gabriele
    Department of Psychiatry and Behavioral Neuroscience, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada, L8N 3Z5
    Synapse 49:261-9. 2003
    ..e., Hsp70 or Hsc70) expression remained unaltered following QNP treatment. Since QNP is a DA D(2)/D(3) agonist, alterations in CRP40 expression following QNP treatment suggest the protein's function in dopaminergic neurotransmission...
  30. pmc Impaired response to amphetamine and neuronal degeneration in the nucleus accumbens of autoimmune MRL-lpr mice
    Kelly K Anderson
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ont, Canada
    Behav Brain Res 166:32-8. 2006
    ..As such, they point to a neurotransmitter-specific regional brain damage which may account for depressive behaviors in neuropsychiatric lupus erythematosus...
  31. ncbi request reprint Differences in the behavioral profile of circling under amphetamine and apomorphine in rats with unilateral lesions of the substantia nigra
    M Ziegler
    McMaster University, Hamilton, Ontario, Canada
    Behav Neurosci 102:276-88, 327. 1988
    ..It seems, therefore, that different behavioral mechanisms may underlie the rotations induced by apomorphine and amphetamine...
  32. ncbi request reprint Presynaptic stimulation and development of locomotor sensitization to the dopamine agonist quinpirole
    Anna Lomanowska
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, 1200 Main Street West, Health Science Centre, Room 4N82, Hamilton, ON, Canada L8N 3Z5
    Pharmacol Biochem Behav 77:617-22. 2004
    ..It is suggested that presynaptic dopamine receptors may require extensive spatial and/or temporal summation to become tolerant...
  33. pmc Proliferating brain cells are a target of neurotoxic CSF in systemic autoimmune disease
    Boris Sakic
    Department of Psychiatry and Behavioural Neurosciences, HSC Rm 4N81, McMaster University, 1200 Main St West, Hamilton, Ontario, Canada L8N 3Z5
    J Neuroimmunol 169:68-85. 2005
    ..Antibody-mediated lesions of germinal layers may impair the regenerative capacity of the brain in NP-SLE and possibly, brain development and function in some forms of CNS disorders in which autoimmune phenomena have been documented...
  34. ncbi request reprint Behavioral effects of infection with IL-6 adenovector
    B Sakic
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Brain Behav Immun 15:25-42. 2001
    ..The inability of circulating IL-6 to alter other aspects of behavior supports the hypothesis that multiple immuno-neuroendocrine mechanisms contribute to the pathogenesis of AABS...
  35. ncbi request reprint Antidepressants attenuate increased susceptibility to colitis in a murine model of depression
    Ashwin K Varghese
    Intestinal Diseases Research Program, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 130:1743-53. 2006
    ..We also examined whether antidepressant therapy attenuates the increased susceptibility to colitis...
  36. ncbi request reprint Taste responsiveness and diet preference in autoimmune MRL mice
    David A Ballok
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Behav Brain Res 140:119-30. 2003
    ..These results further support the hypothesis that the onset of lupus-like disease alters motivated behaviour, independent of changes in neurologic function and food metabolism...
  37. ncbi request reprint Effect of nicotine on quinpirole-induced checking behavior in rats: implications for obsessive-compulsive disorder
    Yousef Tizabi
    Department of Pharmacology, College of Medicine, Howard University, Washington, DC 20059, USA
    Biol Psychiatry 51:164-71. 2002
    ..Because nicotine blocks various behaviors induced by ontogenetic QNP administration, we asked whether nicotine could attenuate QNP-induced compulsive checking...
  38. doi request reprint Effects of hypophysectomy on compulsive checking and cortical dendrites in an animal model of obsessive-compulsive disorder
    Anna Dvorkin
    Department of Zoology, Tel Aviv University, Tel Aviv, Israel
    Behav Pharmacol 19:271-83. 2008
    ..On the basis of the animal model findings, it is concluded that the presence of OCD checking compulsions is not dependent on pituitary axis hormones...
  39. ncbi request reprint Differential effects of clorgyline on sensitization to quinpirole in rats tested in small and large environments
    Anna Dvorkin
    Department of Zoology, Tel Aviv University, Tel Aviv, Israel
    Psychopharmacology (Berl) 186:534-43. 2006
    ..However, like with other psychostimulant drugs, sensitization to quinpirole is modulated by environmental context. It is not known whether the clorgyline cotreatment effect is likewise influenced by the environment...
  40. ncbi request reprint Psychostimulant-induced behavior as an animal model of obsessive-compulsive disorder: an ethological approach to the form of compulsive rituals
    David Eilam
    Department of Zoology, Tel Aviv University, Israel
    CNS Spectr 10:191-202. 2005
    ....
  41. ncbi request reprint Development and temporal organization of compulsive checking induced by repeated injections of the dopamine agonist quinpirole in an animal model of obsessive-compulsive disorder
    Anna Dvorkin
    Department of Zoology, Tel Aviv University, Tel Aviv, Israel
    Behav Brain Res 169:303-11. 2006
    ..Finally, because key variables measured using the newly developed algorithms showed the expected profile, the present study provides validation for the use of this methodology for the analysis of checking behavior...
  42. ncbi request reprint Psychosis pathways converge via D2high dopamine receptors
    Philip Seeman
    Department of Pharmacology, University of Toronto, and Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5S 1A8
    Synapse 60:319-46. 2006
    ..Dopamine supersensitivity, in turn, correlates with D2High states. The finding that all antipsychotics, traditional and recent ones, act on D2High dopamine receptors further supports the proposition...
  43. ncbi request reprint Rituals, stereotypy and compulsive behavior in animals and humans
    David Eilam
    Department of Zoology, Tel Aviv University, Ramat Aviv 69978, Israel
    Neurosci Biobehav Rev 30:456-71. 2006
    ..Such similarity in form may reflect a similarity in the mechanisms that control motor rituals in both animals and humans...