Research Topics
Species | P SzatmariSummaryAffiliation: McMaster University Country: Canada Publications
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Publications
Two-year outcome of preschool children with autism or Asperger's syndromeP Szatmari
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
Am J Psychiatry 157:1980-7. 2000....
Alexithymia in parents of children with autism spectrum disorderPeter Szatmari
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
J Autism Dev Disord 38:1859-65. 2008..The alexithymia trait appears to be one of the many building blocks that make up the BAP...- Sex differences in repetitive stereotyped behaviors in autism: implications for genetic liabilityPeter Szatmari
Offord Centre for Child Studies, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
Am J Med Genet B Neuropsychiatr Genet 159:5-12. 2012..These data also support the dissociation of the different phenotypic dimensions of ASD in terms of its genetic architecture. The implications of these results for linkage and association studies are discussed... - Predictors of outcome among high functioning children with autism and Asperger syndromeP Szatmari
McMaster University, Canada
J Child Psychol Psychiatry 44:520-8. 2003..The objective of this paper is to assess the extent to which measures of cognitive abilities taken in an inception cohort of young high functioning children with autism and Asperger syndrome predict outcome roughly two and six years later... - The use of genetic epidemiology to guide classification in child and adult psychopathologyPeter Szatmari
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
Int Rev Psychiatry 19:483-96. 2007..From these data, a new classification system of the ASDs is proposed based on these familial traits... - Conducting genetic epidemiology studies of autism spectrum disorders: issues in matchingPeter Szatmari
Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada
J Autism Dev Disord 34:49-57. 2004..Matching continues to be an important issue in the planning and conduct of family-genetic studies of the autism spectrum disorders, particularly as the search for autism susceptibility genes enters the next generation of studies... - Decomposing the autism phenotype into familial dimensionsPeter Szatmari
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
Am J Med Genet B Neuropsychiatr Genet 147:3-9. 2008..These findings suggest that non-verbal IQ and language in PDD may arise from independent genetic mechanisms. The implications of this finding for linkage analysis and for identifying genetically informative phenotypes are discussed... - Informative phenotypes for genetic studies of psychiatric disordersPeter Szatmari
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
Am J Med Genet B Neuropsychiatr Genet 144:581-8. 2007..This is a conceptual review with a focus on methodological issues that may arise in psychiatric genetics and examples are taken from the literature on autism, schizophrenia, bipolar disorder, and alcoholism... - Investigating the structure of the restricted, repetitive behaviours and interests domain of autismPeter Szatmari
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Canada
J Child Psychol Psychiatry 47:582-90. 2006..Although this conceptualisation is well accepted in the field, the grouping of symptoms is based primarily on clinical judgment rather than on empirical evidence... - Similar developmental trajectories in autism and Asperger syndrome: from early childhood to adolescencePeter Szatmari
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Canada
J Child Psychol Psychiatry 50:1459-67. 2009.... 
Heterogeneity and the genetics of autismP Szatmari
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ont
J Psychiatry Neurosci 24:159-65. 1999..If true, this will make the detection of linkage and association much more difficult...- The familial aggregation of the lesser variant in biological and nonbiological relatives of PDD probands: a family history studyP Szatmari
McMaster University, Hamilton, Canada
J Child Psychol Psychiatry 41:579-86. 2000.... - Structure of the autism symptom phenotype: A proposed multidimensional modelStelios Georgiades
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
J Am Acad Child Adolesc Psychiatry 46:188-96. 2007.... - High functioning autism and Childhood Disintegrative Disorder in half brothersL Zwaigenbaum
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
J Autism Dev Disord 30:121-6. 2000..Investigations did not reveal any neurodegenerative process. M. P. was diagnosed with CDD. The rarity of the two conditions suggests a shared transmissible mechanism. The implications for autism/PDD genetic studies are discussed... - Differentiating autism and Asperger syndrome on the basis of language delay or impairmentTerry Bennett
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
J Autism Dev Disord 38:616-25. 2008..Diagnostic implications are discussed... - The classification of autism, Asperger's syndrome, and pervasive developmental disorderP Szatmari
Department of Psychiatry and Behavioural Neursosciences, McMaster University, Hamilton, Ontario
Can J Psychiatry 45:731-8. 2000..I review the historical development of the classification of PDD, summarize recent empirical data on issues of reliability and validity, and suggest a new approach to classification and understanding... - Highly somatizing young adolescents and the risk of depressionL Zwaigenbaum
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
Pediatrics 103:1203-9. 1999..To determine if high levels of somatization symptoms in 13- to 16-year-olds from the general population predict risk of major depression and other psychiatric disorders 4 years later... - Behavioral manifestations of autism in the first year of lifeLonnie Zwaigenbaum
Department of Paediatrics, McMaster Children s Hospital, McMaster University, PO Box 2000, Hamilton, Ont, Canada L8N 3Z5
Int J Dev Neurosci 23:143-52. 2005.... - Stereotyped motor behaviors associated with autism in high-risk infants: a pilot videotape analysis of a sibling sampleAlvin Loh
The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
J Autism Dev Disord 37:25-36. 2007..Overall, the siblings subsequently diagnosed with ASD and the comparison groups had considerable overlap in their repertoires of stereotyped behaviors... - How do individuals with autism plan their movements?Cheryl M Glazebrook
Department of Kinesiology, McMaster University, 1280 Main St West, Ivor Wynne Centre, AB108, L8S 4K1, Hamilton, ON, Canada
J Autism Dev Disord 38:114-26. 2008..Overall, individuals with autism used advance information to plan their movements when this information was direct. However, their performance became stereotyped when strategies were self-generated... - Pregnancy and birth complications in autism and liability to the broader autism phenotypeLonnie Zwaigenbaum
Department of Paediatrics, McMaster University, Hamilton, Ontario, Canada
J Am Acad Child Adolesc Psychiatry 41:572-9. 2002..To understand better the relationship between pregnancy and birth complications and genetic factors in autism... - Amygdala engagement in response to subthreshold presentations of anxious face stimuli in adults with autism spectrum disorders: preliminary insightsGeoffrey B C Hall
Department of Psychiatry and Behavioural Neurosciences, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
PLoS ONE 5:e10804. 2010.... - Backward masking: evidence of reduced subcortical amygdala engagement in autismGeoffrey B C Hall
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada
Brain Cogn 65:100-6. 2007.... - Comorbidity of internalizing disorders in children with oppositional defiant disorderKhrista Boylan
Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1200 Main St West, Hamilton, ON, Canada, L8N 3Z5
Eur Child Adolesc Psychiatry 16:484-94. 2007..This could have important implications for the treatment of these ODD children and the prevention of sequential comorbidity... - Teaching evidence-based psychiatry: integrating and aligning the formal and hidden curriculaSacha Agrawal
McMaster University, Psychiatry and Behavioural Neurosciences, Hamilton, Ontario, Canada
Acad Psychiatry 32:470-4. 2008..The authors argue that adopting evidence-based psychiatry will require a paradigm shift in the training of psychiatry residents, and offer some suggestions for how this transformation might be achieved... - Motor coordination and emotional-behavioral problems in childrenJohn Cairney
Offord Centre for Child Studies and Department of Psychiatry and Behavioural Neuroscience, McMaster University, Hamilton, Canada
Curr Opin Psychiatry 23:324-9. 2010..To summarize recent research on developmental coordination disorder (DCD), with particular attention to comorbidity and related questions of etiology... - Cortical serotonin type-2 receptor density in parents of children with autism spectrum disordersJeremy Goldberg
Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, Canada
J Autism Dev Disord 39:97-104. 2009..Further research should examine the relationship of reduced 5-HT2 receptor expression to underlying causation and to clinical and neurochemical correlates of autistic behavior... - The longitudinal association between oppositional and depressive symptoms across childhoodKhrista Boylan
Department of Psychiatry and Behavioral Neurosciences, McMaster University, and the Offord Centre for Child Studies, Hamilton, Ontario, Canada
J Am Acad Child Adolesc Psychiatry 49:152-61. 2010..This study examines the extent to which variation in oppositional symptoms predict, variation in depressive symptoms over time, accounting for co-occurring depressive symptoms and measurement error... - Lack of expansion of triplet repeats in the FMR1, FRAXE, and FRAXF loci in male multiplex families with autism and pervasive developmental disordersJ J Holden
Department of Psychiatry, Queen s University, Kingston, Ontario, Canada
Am J Med Genet 64:399-403. 1996.... - Imaging of autism: lessons from the past to guide studies in the futureJ Goldberg
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario
Can J Psychiatry 44:793-801. 1999..To review the scientific literature on the imaging of autism with a view to understanding how imaging can contribute to future studies... - Brief Report: Relationship between non-verbal IQ and gender in autismRyan Banach
Department of Family Medicine, McMaster University, Hamilton, ON, Canada
J Autism Dev Disord 39:188-93. 2009..Similarly, the affected brothers of girls with autism were no different from affected brothers of male probands. These data suggest that MPX and SPX families differ with respect to the relationship between gender and IQ... - Autism spectrum disorders and epigeneticsDaria Grafodatskaya
Hospital for Sick Children, Toronto, Ontario, Canada
J Am Acad Child Adolesc Psychiatry 49:794-809. 2010..The objective of this review is to illustrate how epigenetic modifications that are known to alter gene expression without changing primary DNA sequence may play a role in the etiology of ASD... - Early language and communication development of infants later diagnosed with autism spectrum disorderShelley Mitchell
Autism Research Unit, The Hospital for Sick Children, Toronto, Ontario, Canada
J Dev Behav Pediatr 27:S69-78. 2006.... - Specifying PDD-NOS: a comparison of PDD-NOS, Asperger syndrome, and autismDarlene R Walker
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
J Am Acad Child Adolesc Psychiatry 43:172-80. 2004..This differentiation may lead to better reliability in diagnosis and to further progress in studies of etiology... - Genome-wide linkage analyses of quantitative and categorical autism subphenotypesXiao Qing Liu
Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
Biol Psychiatry 64:561-70. 2008..Another strategy is to analyze subsets of families that meet certain clinical criteria to reduce genetic heterogeneity... - Quantifying dimensions in autism: a factor-analytic studyPeter Szatmari
Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada
J Am Acad Child Adolesc Psychiatry 41:467-74. 2002..The implications of this dimensional heterogeneity for research, classification, and clinical practice are discussed... - Mapping autism risk loci using genetic linkage and chromosomal rearrangementsPeter Szatmari
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
Nat Genet 39:319-28. 2007..Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs... - Familial influences on substance use by adolescents and young adultsM H Boyle
Department of Psychiatry and Behavioural Neuroscience and Centre for Studies of Children at Risk, McMaster University, Hamilton, ON
Can J Public Health 92:206-9. 2001.... - Human chromosome 7: DNA sequence and biologyStephen W Scherer
Department of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8
Science 300:767-72. 2003..This approach enabled the discovery of candidate genes for developmental diseases including autism... - Absence of a paternally inherited FOXP2 gene in developmental verbal dyspraxiaLars Feuk
The Centre for Applied Genomics and Program in Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
Am J Hum Genet 79:965-72. 2006..Our results indicate that absence of paternal FOXP2 is the cause of DVD in patients with SRS with maternal UPD7. The data also point to a role for differential parent-of-origin expression of FOXP2 in human speech development... - The art of evidence-based child psychiatryPeter Szatmari
McMaster University, Canada
Evid Based Ment Health 6:99-100. 2003 - Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disabilityAbdul Noor
Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Sci Transl Med 2:49ra68. 2010..Thus, our systematic screen of PTCHD1 and its 5' flanking regions suggests that this locus is involved in ~1% of individuals with ASD and intellectual disability... - Contribution of SHANK3 mutations to autism spectrum disorderRainald Moessner
The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, M5G 1L7, Canada
Am J Hum Genet 81:1289-97. 2007..The combined data provide support that haploinsufficiency of SHANK3 can cause a monogenic form of autism in sufficient frequency to warrant consideration in clinical diagnostic testing... - A risk-factor model of epistatic interaction, focusing on autismMarshall B Jones
Department of Behavioral Science, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
Am J Med Genet 114:558-65. 2002..quot; The principal point of difference is whether the effects of different causes cumulate or do not cumulate. In the present approach they do, in Gillberg and Coleman's they do not... - Stability and change among high-functioning children with pervasive developmental disorders: a 2-year outcome studyElizabeth Starr
Faculty of Education, University of Windsor, Windsor, Canada
J Autism Dev Disord 33:15-22. 2003..Results suggest that the two PDD subtypes represent similar developmental trajectories, although the Asperger syndrome group maintains its advantage. Educational and clinical implications of the results are discussed... - Brief report: a scale for rating conversational impairment in autism spectrum disorderJessica de Villiers
Department of English, University of British Columbia, V8N 1Z4, Voncouver, BC, Canada
J Autism Dev Disord 37:1375-80. 2007..This tool represents a way of characterizing language use in ASD and is an initial step towards developing a tool to evaluate change in degree of social impairments in conversation... - A prospective case series of high-risk infants who developed autismSusan E Bryson
Autism Research Centre, IWK Health Centre, Dalhousie University, 5850 University Avenue, Halifax, NS, Canada, B3K 6R8
J Autism Dev Disord 37:12-24. 2007..Discussion focuses on issues raised by the pattern of findings... - A pilot feasibility study of an extension of the acquaintanceship recruitment procedure in recent-onset psychosisCatherine Lehoux
, Beauport, , Canada
J Nerv Ment Dis 193:560-3. 2005..This pilot study suggests that several obstacles prevent the use of this procedure to recruit controls in this research focusing on recent-onset psychotic disorders... - Modifier effects in autism at the MAO-A and DBH lociMarshall B Jones
Department of Behavioral Science, The Pennsylvania State University College of Medicine, Hershey, PA, USA
Am J Med Genet B Neuropsychiatr Genet 126:58-65. 2004..Susceptibility effects were also found but not without qualification. We conclude that maternal genotypes at the MAO-A locus, and possibly at the DBH one, may modify IQ in children with autism through the intrauterine environment... - The search for autism disease genesThomas H Wassink
Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Ment Retard Dev Disabil Res Rev 10:272-83. 2004.... - Structural variation of chromosomes in autism spectrum disorderChristian R Marshall
The Centre for Applied Genomics, The Hospital for Sick Children, Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5G 1L7, Canada
Am J Hum Genet 82:477-88. 2008..Structural variants were found in sufficiently high frequency influencing ASD to suggest that cytogenetic and microarray analyses be considered in routine clinical workup... - Challenges in evaluating psychosocial interventions for Autistic Spectrum DisordersCatherine Lord
University of Michigan, Austim and Communication Disorders Center 1111, Ann Arbor 48109, USA
J Autism Dev Disord 35:695-708; discussion 709-11. 2005.... - Response to Dr. GuptaPeter Szatmari
Evid Based Ment Health 7:97-8. 2004 - Immunization uptake in siblings of children with autismGhassan Kuwaik
Pediatrics 122:684-5; author reply 685-6. 2008 - Clinical practice guidelinesPeter Szatmari
J Am Acad Child Adolesc Psychiatry 46:939-40; discussion 940-2. 2007 - Genetic and neurodevelopmental influences in autistic disorderRob Nicolson
Department of Psychiatry, University of Western Ontario, London, Ontario
Can J Psychiatry 48:526-37. 2003..However, research in the last 2 decades indicates that autism is largely caused by genetic factors that lead to abnormal brain development. This article reviews research into the genetic and neurodevelopmental factors underlying autism... - The causes of autism spectrum disordersPeter Szatmari
BMJ 326:173-4. 2003 - Combining information from multiple sources in the diagnosis of autism spectrum disordersSusan Risi
University of Michigan Autism and Communication Disorders Center, Ann Arbor 48109 2054, USA
J Am Acad Child Adolesc Psychiatry 45:1094-103. 2006..Standard case criteria are proposed for combined use of the Autism Diagnostic Interview-Revised and Autism Diagnostic Observation Schedule to diagnose autism and to define the broader category of autism spectrum disorders...