P Szatmari

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint Two-year outcome of preschool children with autism or Asperger's syndrome
    P Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Am J Psychiatry 157:1980-7. 2000
  2. doi request reprint Alexithymia in parents of children with autism spectrum disorder
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    J Autism Dev Disord 38:1859-65. 2008
  3. doi request reprint Sex differences in repetitive stereotyped behaviors in autism: implications for genetic liability
    Peter Szatmari
    Offord Centre for Child Studies, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 159:5-12. 2012
  4. ncbi request reprint Predictors of outcome among high functioning children with autism and Asperger syndrome
    P Szatmari
    McMaster University, Canada
    J Child Psychol Psychiatry 44:520-8. 2003
  5. ncbi request reprint The use of genetic epidemiology to guide classification in child and adult psychopathology
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Int Rev Psychiatry 19:483-96. 2007
  6. ncbi request reprint Conducting genetic epidemiology studies of autism spectrum disorders: issues in matching
    Peter Szatmari
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Autism Dev Disord 34:49-57. 2004
  7. ncbi request reprint Decomposing the autism phenotype into familial dimensions
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 147:3-9. 2008
  8. ncbi request reprint Informative phenotypes for genetic studies of psychiatric disorders
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 144:581-8. 2007
  9. ncbi request reprint Investigating the structure of the restricted, repetitive behaviours and interests domain of autism
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Canada
    J Child Psychol Psychiatry 47:582-90. 2006
  10. doi request reprint Similar developmental trajectories in autism and Asperger syndrome: from early childhood to adolescence
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Canada
    J Child Psychol Psychiatry 50:1459-67. 2009

Detail Information

Publications58

  1. ncbi request reprint Two-year outcome of preschool children with autism or Asperger's syndrome
    P Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Am J Psychiatry 157:1980-7. 2000
    ....
  2. doi request reprint Alexithymia in parents of children with autism spectrum disorder
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    J Autism Dev Disord 38:1859-65. 2008
    ..The alexithymia trait appears to be one of the many building blocks that make up the BAP...
  3. doi request reprint Sex differences in repetitive stereotyped behaviors in autism: implications for genetic liability
    Peter Szatmari
    Offord Centre for Child Studies, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 159:5-12. 2012
    ..These data also support the dissociation of the different phenotypic dimensions of ASD in terms of its genetic architecture. The implications of these results for linkage and association studies are discussed...
  4. ncbi request reprint Predictors of outcome among high functioning children with autism and Asperger syndrome
    P Szatmari
    McMaster University, Canada
    J Child Psychol Psychiatry 44:520-8. 2003
    ..The objective of this paper is to assess the extent to which measures of cognitive abilities taken in an inception cohort of young high functioning children with autism and Asperger syndrome predict outcome roughly two and six years later...
  5. ncbi request reprint The use of genetic epidemiology to guide classification in child and adult psychopathology
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Int Rev Psychiatry 19:483-96. 2007
    ..From these data, a new classification system of the ASDs is proposed based on these familial traits...
  6. ncbi request reprint Conducting genetic epidemiology studies of autism spectrum disorders: issues in matching
    Peter Szatmari
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Autism Dev Disord 34:49-57. 2004
    ..Matching continues to be an important issue in the planning and conduct of family-genetic studies of the autism spectrum disorders, particularly as the search for autism susceptibility genes enters the next generation of studies...
  7. ncbi request reprint Decomposing the autism phenotype into familial dimensions
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 147:3-9. 2008
    ..These findings suggest that non-verbal IQ and language in PDD may arise from independent genetic mechanisms. The implications of this finding for linkage analysis and for identifying genetically informative phenotypes are discussed...
  8. ncbi request reprint Informative phenotypes for genetic studies of psychiatric disorders
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 144:581-8. 2007
    ..This is a conceptual review with a focus on methodological issues that may arise in psychiatric genetics and examples are taken from the literature on autism, schizophrenia, bipolar disorder, and alcoholism...
  9. ncbi request reprint Investigating the structure of the restricted, repetitive behaviours and interests domain of autism
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Canada
    J Child Psychol Psychiatry 47:582-90. 2006
    ..Although this conceptualisation is well accepted in the field, the grouping of symptoms is based primarily on clinical judgment rather than on empirical evidence...
  10. doi request reprint Similar developmental trajectories in autism and Asperger syndrome: from early childhood to adolescence
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Canada
    J Child Psychol Psychiatry 50:1459-67. 2009
    ....
  11. pmc Heterogeneity and the genetics of autism
    P Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ont
    J Psychiatry Neurosci 24:159-65. 1999
    ..If true, this will make the detection of linkage and association much more difficult...
  12. ncbi request reprint The familial aggregation of the lesser variant in biological and nonbiological relatives of PDD probands: a family history study
    P Szatmari
    McMaster University, Hamilton, Canada
    J Child Psychol Psychiatry 41:579-86. 2000
    ....
  13. ncbi request reprint Structure of the autism symptom phenotype: A proposed multidimensional model
    Stelios Georgiades
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Am Acad Child Adolesc Psychiatry 46:188-96. 2007
    ....
  14. ncbi request reprint High functioning autism and Childhood Disintegrative Disorder in half brothers
    L Zwaigenbaum
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    J Autism Dev Disord 30:121-6. 2000
    ..Investigations did not reveal any neurodegenerative process. M. P. was diagnosed with CDD. The rarity of the two conditions suggests a shared transmissible mechanism. The implications for autism/PDD genetic studies are discussed...
  15. ncbi request reprint Differentiating autism and Asperger syndrome on the basis of language delay or impairment
    Terry Bennett
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Autism Dev Disord 38:616-25. 2008
    ..Diagnostic implications are discussed...
  16. ncbi request reprint The classification of autism, Asperger's syndrome, and pervasive developmental disorder
    P Szatmari
    Department of Psychiatry and Behavioural Neursosciences, McMaster University, Hamilton, Ontario
    Can J Psychiatry 45:731-8. 2000
    ..I review the historical development of the classification of PDD, summarize recent empirical data on issues of reliability and validity, and suggest a new approach to classification and understanding...
  17. ncbi request reprint Highly somatizing young adolescents and the risk of depression
    L Zwaigenbaum
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    Pediatrics 103:1203-9. 1999
    ..To determine if high levels of somatization symptoms in 13- to 16-year-olds from the general population predict risk of major depression and other psychiatric disorders 4 years later...
  18. ncbi request reprint Behavioral manifestations of autism in the first year of life
    Lonnie Zwaigenbaum
    Department of Paediatrics, McMaster Children s Hospital, McMaster University, PO Box 2000, Hamilton, Ont, Canada L8N 3Z5
    Int J Dev Neurosci 23:143-52. 2005
    ....
  19. ncbi request reprint Stereotyped motor behaviors associated with autism in high-risk infants: a pilot videotape analysis of a sibling sample
    Alvin Loh
    The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    J Autism Dev Disord 37:25-36. 2007
    ..Overall, the siblings subsequently diagnosed with ASD and the comparison groups had considerable overlap in their repertoires of stereotyped behaviors...
  20. ncbi request reprint How do individuals with autism plan their movements?
    Cheryl M Glazebrook
    Department of Kinesiology, McMaster University, 1280 Main St West, Ivor Wynne Centre, AB108, L8S 4K1, Hamilton, ON, Canada
    J Autism Dev Disord 38:114-26. 2008
    ..Overall, individuals with autism used advance information to plan their movements when this information was direct. However, their performance became stereotyped when strategies were self-generated...
  21. ncbi request reprint Pregnancy and birth complications in autism and liability to the broader autism phenotype
    Lonnie Zwaigenbaum
    Department of Paediatrics, McMaster University, Hamilton, Ontario, Canada
    J Am Acad Child Adolesc Psychiatry 41:572-9. 2002
    ..To understand better the relationship between pregnancy and birth complications and genetic factors in autism...
  22. pmc Amygdala engagement in response to subthreshold presentations of anxious face stimuli in adults with autism spectrum disorders: preliminary insights
    Geoffrey B C Hall
    Department of Psychiatry and Behavioural Neurosciences, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 5:e10804. 2010
    ....
  23. ncbi request reprint Backward masking: evidence of reduced subcortical amygdala engagement in autism
    Geoffrey B C Hall
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada
    Brain Cogn 65:100-6. 2007
    ....
  24. ncbi request reprint Comorbidity of internalizing disorders in children with oppositional defiant disorder
    Khrista Boylan
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1200 Main St West, Hamilton, ON, Canada, L8N 3Z5
    Eur Child Adolesc Psychiatry 16:484-94. 2007
    ..This could have important implications for the treatment of these ODD children and the prevention of sequential comorbidity...
  25. doi request reprint Teaching evidence-based psychiatry: integrating and aligning the formal and hidden curricula
    Sacha Agrawal
    McMaster University, Psychiatry and Behavioural Neurosciences, Hamilton, Ontario, Canada
    Acad Psychiatry 32:470-4. 2008
    ..The authors argue that adopting evidence-based psychiatry will require a paradigm shift in the training of psychiatry residents, and offer some suggestions for how this transformation might be achieved...
  26. doi request reprint Motor coordination and emotional-behavioral problems in children
    John Cairney
    Offord Centre for Child Studies and Department of Psychiatry and Behavioural Neuroscience, McMaster University, Hamilton, Canada
    Curr Opin Psychiatry 23:324-9. 2010
    ..To summarize recent research on developmental coordination disorder (DCD), with particular attention to comorbidity and related questions of etiology...
  27. doi request reprint Cortical serotonin type-2 receptor density in parents of children with autism spectrum disorders
    Jeremy Goldberg
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, Canada
    J Autism Dev Disord 39:97-104. 2009
    ..Further research should examine the relationship of reduced 5-HT2 receptor expression to underlying causation and to clinical and neurochemical correlates of autistic behavior...
  28. ncbi request reprint The longitudinal association between oppositional and depressive symptoms across childhood
    Khrista Boylan
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, and the Offord Centre for Child Studies, Hamilton, Ontario, Canada
    J Am Acad Child Adolesc Psychiatry 49:152-61. 2010
    ..This study examines the extent to which variation in oppositional symptoms predict, variation in depressive symptoms over time, accounting for co-occurring depressive symptoms and measurement error...
  29. ncbi request reprint Lack of expansion of triplet repeats in the FMR1, FRAXE, and FRAXF loci in male multiplex families with autism and pervasive developmental disorders
    J J Holden
    Department of Psychiatry, Queen s University, Kingston, Ontario, Canada
    Am J Med Genet 64:399-403. 1996
    ....
  30. ncbi request reprint Imaging of autism: lessons from the past to guide studies in the future
    J Goldberg
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario
    Can J Psychiatry 44:793-801. 1999
    ..To review the scientific literature on the imaging of autism with a view to understanding how imaging can contribute to future studies...
  31. doi request reprint Brief Report: Relationship between non-verbal IQ and gender in autism
    Ryan Banach
    Department of Family Medicine, McMaster University, Hamilton, ON, Canada
    J Autism Dev Disord 39:188-93. 2009
    ..Similarly, the affected brothers of girls with autism were no different from affected brothers of male probands. These data suggest that MPX and SPX families differ with respect to the relationship between gender and IQ...
  32. doi request reprint Autism spectrum disorders and epigenetics
    Daria Grafodatskaya
    Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Acad Child Adolesc Psychiatry 49:794-809. 2010
    ..The objective of this review is to illustrate how epigenetic modifications that are known to alter gene expression without changing primary DNA sequence may play a role in the etiology of ASD...
  33. ncbi request reprint Early language and communication development of infants later diagnosed with autism spectrum disorder
    Shelley Mitchell
    Autism Research Unit, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Dev Behav Pediatr 27:S69-78. 2006
    ....
  34. ncbi request reprint Specifying PDD-NOS: a comparison of PDD-NOS, Asperger syndrome, and autism
    Darlene R Walker
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Am Acad Child Adolesc Psychiatry 43:172-80. 2004
    ....
  35. pmc Genome-wide linkage analyses of quantitative and categorical autism subphenotypes
    Xiao Qing Liu
    Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Biol Psychiatry 64:561-70. 2008
    ..Another strategy is to analyze subsets of families that meet certain clinical criteria to reduce genetic heterogeneity...
  36. ncbi request reprint Quantifying dimensions in autism: a factor-analytic study
    Peter Szatmari
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Am Acad Child Adolesc Psychiatry 41:467-74. 2002
    ....
  37. ncbi request reprint Mapping autism risk loci using genetic linkage and chromosomal rearrangements
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Nat Genet 39:319-28. 2007
    ..Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs...
  38. ncbi request reprint Familial influences on substance use by adolescents and young adults
    M H Boyle
    Department of Psychiatry and Behavioural Neuroscience and Centre for Studies of Children at Risk, McMaster University, Hamilton, ON
    Can J Public Health 92:206-9. 2001
    ....
  39. pmc Human chromosome 7: DNA sequence and biology
    Stephen W Scherer
    Department of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8
    Science 300:767-72. 2003
    ..This approach enabled the discovery of candidate genes for developmental diseases including autism...
  40. pmc Absence of a paternally inherited FOXP2 gene in developmental verbal dyspraxia
    Lars Feuk
    The Centre for Applied Genomics and Program in Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Hum Genet 79:965-72. 2006
    ..Our results indicate that absence of paternal FOXP2 is the cause of DVD in patients with SRS with maternal UPD7. The data also point to a role for differential parent-of-origin expression of FOXP2 in human speech development...
  41. ncbi request reprint The art of evidence-based child psychiatry
    Peter Szatmari
    McMaster University, Canada
    Evid Based Ment Health 6:99-100. 2003
  42. pmc Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability
    Abdul Noor
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Sci Transl Med 2:49ra68. 2010
    ..Thus, our systematic screen of PTCHD1 and its 5' flanking regions suggests that this locus is involved in ~1% of individuals with ASD and intellectual disability...
  43. pmc Contribution of SHANK3 mutations to autism spectrum disorder
    Rainald Moessner
    The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, M5G 1L7, Canada
    Am J Hum Genet 81:1289-97. 2007
    ..The combined data provide support that haploinsufficiency of SHANK3 can cause a monogenic form of autism in sufficient frequency to warrant consideration in clinical diagnostic testing...
  44. ncbi request reprint A risk-factor model of epistatic interaction, focusing on autism
    Marshall B Jones
    Department of Behavioral Science, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Am J Med Genet 114:558-65. 2002
    ..quot; The principal point of difference is whether the effects of different causes cumulate or do not cumulate. In the present approach they do, in Gillberg and Coleman's they do not...
  45. ncbi request reprint Stability and change among high-functioning children with pervasive developmental disorders: a 2-year outcome study
    Elizabeth Starr
    Faculty of Education, University of Windsor, Windsor, Canada
    J Autism Dev Disord 33:15-22. 2003
    ..Results suggest that the two PDD subtypes represent similar developmental trajectories, although the Asperger syndrome group maintains its advantage. Educational and clinical implications of the results are discussed...
  46. ncbi request reprint Brief report: a scale for rating conversational impairment in autism spectrum disorder
    Jessica de Villiers
    Department of English, University of British Columbia, V8N 1Z4, Voncouver, BC, Canada
    J Autism Dev Disord 37:1375-80. 2007
    ..This tool represents a way of characterizing language use in ASD and is an initial step towards developing a tool to evaluate change in degree of social impairments in conversation...
  47. ncbi request reprint A prospective case series of high-risk infants who developed autism
    Susan E Bryson
    Autism Research Centre, IWK Health Centre, Dalhousie University, 5850 University Avenue, Halifax, NS, Canada, B3K 6R8
    J Autism Dev Disord 37:12-24. 2007
    ..Discussion focuses on issues raised by the pattern of findings...
  48. ncbi request reprint A pilot feasibility study of an extension of the acquaintanceship recruitment procedure in recent-onset psychosis
    Catherine Lehoux
    Centre de Recherche Universite Laval Robert Giffard, Beauport, Quebec, Canada
    J Nerv Ment Dis 193:560-3. 2005
    ..This pilot study suggests that several obstacles prevent the use of this procedure to recruit controls in this research focusing on recent-onset psychotic disorders...
  49. ncbi request reprint Modifier effects in autism at the MAO-A and DBH loci
    Marshall B Jones
    Department of Behavioral Science, The Pennsylvania State University College of Medicine, Hershey, PA, USA
    Am J Med Genet B Neuropsychiatr Genet 126:58-65. 2004
    ..Susceptibility effects were also found but not without qualification. We conclude that maternal genotypes at the MAO-A locus, and possibly at the DBH one, may modify IQ in children with autism through the intrauterine environment...
  50. ncbi request reprint The search for autism disease genes
    Thomas H Wassink
    Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Ment Retard Dev Disabil Res Rev 10:272-83. 2004
    ....
  51. pmc Structural variation of chromosomes in autism spectrum disorder
    Christian R Marshall
    The Centre for Applied Genomics, The Hospital for Sick Children, Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5G 1L7, Canada
    Am J Hum Genet 82:477-88. 2008
    ..Structural variants were found in sufficiently high frequency influencing ASD to suggest that cytogenetic and microarray analyses be considered in routine clinical workup...
  52. ncbi request reprint Challenges in evaluating psychosocial interventions for Autistic Spectrum Disorders
    Catherine Lord
    University of Michigan, Austim and Communication Disorders Center 1111, Ann Arbor 48109, USA
    J Autism Dev Disord 35:695-708; discussion 709-11. 2005
    ....
  53. ncbi request reprint Response to Dr. Gupta
    Peter Szatmari
    Evid Based Ment Health 7:97-8. 2004
  54. doi request reprint Immunization uptake in siblings of children with autism
    Ghassan Kuwaik
    Pediatrics 122:684-5; author reply 685-6. 2008
  55. ncbi request reprint Clinical practice guidelines
    Peter Szatmari
    J Am Acad Child Adolesc Psychiatry 46:939-40; discussion 940-2. 2007
  56. ncbi request reprint Genetic and neurodevelopmental influences in autistic disorder
    Rob Nicolson
    Department of Psychiatry, University of Western Ontario, London, Ontario
    Can J Psychiatry 48:526-37. 2003
    ..However, research in the last 2 decades indicates that autism is largely caused by genetic factors that lead to abnormal brain development. This article reviews research into the genetic and neurodevelopmental factors underlying autism...
  57. pmc The causes of autism spectrum disorders
    Peter Szatmari
    BMJ 326:173-4. 2003
  58. ncbi request reprint Combining information from multiple sources in the diagnosis of autism spectrum disorders
    Susan Risi
    University of Michigan Autism and Communication Disorders Center, Ann Arbor 48109 2054, USA
    J Am Acad Child Adolesc Psychiatry 45:1094-103. 2006
    ..Standard case criteria are proposed for combined use of the Autism Diagnostic Interview-Revised and Autism Diagnostic Observation Schedule to diagnose autism and to define the broader category of autism spectrum disorders...