Research Topics
Genomes and Genes
| Gregory R SteinbergSummaryAffiliation: McMaster University Country: Canada Publications
| Collaborators
|
Detail Information
Publications
Ciliary neurotrophic factor stimulates muscle glucose uptake by a PI3-kinase-dependent pathway that is impaired with obesityGregory R Steinberg
St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Melbourne, Australia
Diabetes 58:829-39. 2009..CNTF also increases Akt signaling in neurons and adipocytes. Because both Akt and AMPK regulate glucose uptake, we investigated muscle glucose uptake in response to CNTF signaling in lean and obese mice...
AMPK in Health and DiseaseGregory R Steinberg
Protein Chemistry and Metabolism, St Vincent s Institute of Medical Research, University of Melbourne, Fitzroy, Victoria, Australia
Physiol Rev 89:1025-78. 2009..Lastly, we review the possible role of AMPK in multiple common diseases and the role of the new age of drugs targeting AMPK signaling...- Role of the AMP-activated protein kinase in regulating fatty acid metabolism during exerciseGregory R Steinberg
St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria 3065, Australia
Appl Physiol Nutr Metab 34:315-22. 2009.... - AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistanceNicolas Dzamko
Department of Medicine, St Vincent s Institute of Medical Research, University of Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
J Biol Chem 285:115-22. 2010..We demonstrate that the loss of beta1 reduces food intake and protects against the deleterious effects of an obesity-inducing diet... 
The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humansGregory R Steinberg
St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
J Clin Endocrinol Metab 91:3592-7. 2006..Human obesity is associated with leptin resistance, and recent studies have demonstrated that hypothalamic expression of the suppressors of cytokine signaling 3 (SOCS3) regulates leptin sensitivity in rodents...- Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesityNirupa Sachithanandan
St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
Hepatology 52:1632-42. 2010..CONCLUSION: Deletion of SOCS3 in the liver increases liver insulin sensitivity in mice fed a control diet but paradoxically promotes lipogenesis, leading to the development of nonalcoholic fatty liver disease, inflammation, and obesity... - AMPK-independent pathways regulate skeletal muscle fatty acid oxidationNicolas Dzamko
St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
J Physiol 586:5819-31. 2008..These data demonstrate that AMPK is not essential for the regulation of fatty acid oxidation by AICAR or muscle contraction... - Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissueMatthew J Watt
Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, PO Box 71, Bundoora 3083, Victoria, Australia
Am J Physiol Endocrinol Metab 290:E500-8. 2006..Taken together, these data indicate that HSL activity is maintained in the face of AMPK activation as a result of elevated HSL Ser(660) phosphorylation in adipose tissue but not skeletal muscle... - Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese miceGregory R Steinberg
St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
Endocrinology 147:3906-14. 2006..A HFD blunted leptin but not CNTF effects on AMPK signaling in the ARC and PVN. In summary, these data demonstrate that CNTF(Ax15) bypasses diet-induced leptin resistance to reduce hypothalamic AMPK activity... - Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signalingGregory R Steinberg
St Vincent s Institute and Department of Medicine, University of Melbourne, Fitzroy, Vic, 3065, Australia
Cell Metab 4:465-74. 2006..Our data demonstrate that AMPK is an important TNFalpha signaling target and is a contributing factor to the suppression of fatty-acid oxidation and the development of lipid-induced insulin resistance in obesity... - Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesitySandra Galic
St Vincent s Institute of Medical Research, University of Melbourne, Fitzroy, Victoria, Australia
J Clin Invest 121:4903-15. 2011..Thus, activation of AMPK β1 and increasing fatty acid oxidation in macrophages may represent a new therapeutic approach for the treatment of insulin resistance... - Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocationSebastian Beck Jørgensen
St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia
Am J Physiol Endocrinol Metab 297:E57-66. 2009..We conclude that resistin impairs insulin-stimulated glucose uptake by mechanisms involving reduced plasma membrane GLUT4 translocation but independent of the proximal insulin-signaling cascade, AMPK, and SOCS-3... - Deficiency in interferon-gamma results in reduced body weight and better glucose tolerance in miceNicole Wong
University of Melbourne, Department of Medicine Austin Health and Northern Health, Heidelberg Repatriation Hospital, 300 Waterdale Road, Heidelberg Heights, Victoria 3081, Australia
Endocrinology 152:3690-9. 2011..Our findings demonstrate that IFNγ plays a critical role in the regulation of body weight and glucose metabolism... - Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARalpha and UCP2 expression in ratsAnna G Holmes
Diabetes and Metabolism Division, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
J Endocrinol 198:367-74. 2008..Our results do not support the notion that prolonged chronically elevated IL-6 impairs insulin action in vivo... - PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscleRobert J Southgate
Cellular and Molecular Metabolism Laboratory, RMIT University, Bundoora, Victoria, Australia
FASEB J 19:2072-4. 2005..We conclude that insulin decreases the expression of genes involved in oxidative metabolism in healthy but not insulin resistant muscle, due to a decrease in FoxO1 phosphorylation and nuclear exclusion secondary to reduced Akt activity... - Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubesMatthew J Watt
Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, Victoria, Australia
J Physiol 574:139-47. 2006.... - Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistanceNirupa Sachithanandan
St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
Diabetes 60:2023-31. 2011..In the current study, we investigated the physiological role of myeloid and lymphoid cell SOCS1 in regulating inflammation and insulin sensitivity... - The AMP-activated protein kinase: role in regulation of skeletal muscle metabolism and insulin sensitivityGregory R Steinberg
St Vincent s Institute of Medical Research, Australia
Mini Rev Med Chem 7:519-26. 2007.... - Reduced glycogen availability is associated with increased AMPKalpha2 activity, nuclear AMPKalpha2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscleGregory R Steinberg
Vincent s Institute and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
Appl Physiol Nutr Metab 31:302-12. 2006..We suggest that increased activation of AMPK alpha2 under conditions of low muscle glycogen enhances AMPK alpha2 nuclear translocation and increases GLUT4 mRNA expression in response to exercise in human skeletal muscle... - AMP-activated protein kinase--the fat controller of the energy railroadGregory R Steinberg
St. Vincent's Institute, 41 Victoria Pd, Fitzroy, 3065 Victoria, Australia
Can J Physiol Pharmacol 84:655-65. 2006..As such, it can be considered to be the fat controller of the energy railroad. It is thought that AMPK may be a major mediator of the health benefits of exercise in mitigating the development of obesity and age-onset diseases... - Inflammation in obesity is the common link between defects in fatty acid metabolism and insulin resistanceGregory R Steinberg
St Vincent s Institute, Fitzroy, Victoria, Australia
Cell Cycle 6:888-94. 2007..1) These data identify a novel mechanism by which inflammation in obesity is a precursor to defects in skeletal muscle fatty acid oxidation that generates a vicious cycle exacerbating the development of insulin resistance... - Low salt concentrations activate AMP-activated protein kinase in mouse macula densa cellsNatasha Cook
Dept of Nephrology, Austin Health, Studley Rd, Heidelberg 3084, Victoria, Australia
Am J Physiol Renal Physiol 296:F801-9. 2009..Phosphorylation of these substrates in vivo is predicted to increase intracellular chloride and so reduce the effect of salt restriction on tubuloglomerular feedback and renin secretion... - Beta-adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signalingMatthew J Watt
Skeletal Muscle Research Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology, Bundoora, Victoria, Australia
FASEB J 18:1445-6. 2004..However, the increased IMTG degradation in LG suggests factors other than HSL activity are important for IMTG degradation... - Adipose tissue as an endocrine organSandra Galic
St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia
Mol Cell Endocrinol 316:129-39. 2010.... - Skeletal muscle glucose uptake during contraction is regulated by nitric oxide and ROS independently of AMPKTroy L Merry
Dept of Physiology, Univ of Melbourne, Victoria, Australia
Am J Physiol Endocrinol Metab 298:E577-85. 2010..In conclusion, ROS and NO are involved in regulating skeletal muscle glucose uptake during contraction via an AMPK-independent mechanism... - Adiponectin: starving for attentionGregory R Steinberg
St Vincent s Institute, Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
Cell Metab 6:3-4. 2007..A new study from the Kadowaki laboratory (Kubota et al., 2007) shows that the adipocyte-derived hormone adiponectin increases appetite and reduces energy expenditure by stimulating AMPK in the hypothalamus... - Impaired activation of AMP-kinase and fatty acid oxidation by globular adiponectin in cultured human skeletal muscle of obese type 2 diabeticsMichael B Chen
St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
J Clin Endocrinol Metab 90:3665-72. 2005..These data suggest that reduced activation of AMPK by gAD in obese and obese type 2 diabetic subjects is not caused by reduced adiponectin receptor expression but that aspects downstream of the receptor may inhibit AMPK signaling... - AMP-activated protein kinase is not down-regulated in human skeletal muscle of obese femalesGregory R Steinberg
St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria, Australia 3065
J Clin Endocrinol Metab 89:4575-80. 2004.... - Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPKPeter F Mount
Department of Nephrology, Austin Health, Heidelberg, Victoria, Australia
Atherosclerosis 200:28-36. 2008..The effect of BK on endothelial lipid metabolism represents a novel pathway for targeting fatty acid mediated endothelial cell dysfunction... - High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitusBrian G Drew
Baker IDI Heart and Diabetes Institute, Melbourne, Australia
Circulation 119:2103-11. 2009..We hypothesized that HDL modulates glucose metabolism via elevation of plasma insulin and through activation of the key metabolic regulatory enzyme, AMP-activated protein kinase, in skeletal muscle... - Subcellular localization of cyclic AMP-responsive element binding protein-regulated transcription coactivator 2 provides a link between obesity and breast cancer in postmenopausal womenKristy A Brown
Prince Henry s Institute, Monash Medical Centre, Clayton, Victoria, Australia
Cancer Res 69:5392-9. 2009..In conclusion, the regulation of aromatase by CRTC2, in response to the altered hormonal milieu associated with menopause and obesity, provides a critical link between obesity and breast cancer... - Adipocyte triglyceride lipase expression in human obesityGregory R Steinberg
St Vincent s Institute, Department of Medicine, The University of Melbourne, Fitzroy, Victoria, Australia
Am J Physiol Endocrinol Metab 293:E958-64. 2007.... - Socs1 deficiency enhances hepatic insulin signalingEmma Jamieson
St Vincent s Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
J Biol Chem 280:31516-21. 2005..Socs1 deficiency increases IRS-2 expression and enhances hepatic insulin sensitivity in vivo indicating that inhibition of SOCS1 may be a logical strategy in type 2 diabetes... - Impact of SOCS3 overexpression on human skeletal muscle development in vitroMarissa K Caldow
Molecular Nutrition Unit, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia
Cytokine 55:104-9. 2011..Thus SOCS3 influences myoblast differentiation and SOCS3 may be significant in regulating the activity of genes previously identified as transcriptionally regulated by STAT3... - Cytokine Regulation of AMPK signallingGregory R Steinberg
St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia
Front Biosci 14:1902-16. 2009.... - Reduced plasma FFA availability increases net triacylglycerol degradation, but not GPAT or HSL activity, in human skeletal muscleMatthew J Watt
Skeletal Muscle Research Laboratory, School of Medical Sciences, RMIT Univ, PO Box 71, Bundoora 3083, Victoria, Australia
Am J Physiol Endocrinol Metab 287:E120-7. 2004..These changes in IMTG degradation appear to disassociate, however, from the activity of the key enzymes responsible for synthesis and degradation of this substrate...