Gregory R Steinberg

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. pmc Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance
    Nirupa Sachithanandan
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
    Diabetes 60:2023-31. 2011
  2. ncbi request reprint AMPK: mediating the metabolic effects of salicylate-based drugs?
    Gregory R Steinberg
    Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario L8N 3Z5, Canada Electronic address
    Trends Endocrinol Metab 24:481-7. 2013
  3. pmc Ciliary neurotrophic factor stimulates muscle glucose uptake by a PI3-kinase-dependent pathway that is impaired with obesity
    Gregory R Steinberg
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Melbourne, Australia
    Diabetes 58:829-39. 2009
  4. doi request reprint Role of the AMP-activated protein kinase in regulating fatty acid metabolism during exercise
    Gregory R Steinberg
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria 3065, Australia
    Appl Physiol Nutr Metab 34:315-22. 2009
  5. doi request reprint AMPK in Health and Disease
    Gregory R Steinberg
    Protein Chemistry and Metabolism, St Vincent s Institute of Medical Research, University of Melbourne, Fitzroy, Victoria, Australia
    Physiol Rev 89:1025-78. 2009
  6. pmc AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance
    Nicolas Dzamko
    Department of Medicine, St Vincent s Institute of Medical Research, University of Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    J Biol Chem 285:115-22. 2010
  7. doi request reprint Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity
    Nirupa Sachithanandan
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
    Hepatology 52:1632-42. 2010
  8. ncbi request reprint The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humans
    Gregory R Steinberg
    St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
    J Clin Endocrinol Metab 91:3592-7. 2006
  9. pmc AMPK-independent pathways regulate skeletal muscle fatty acid oxidation
    Nicolas Dzamko
    St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
    J Physiol 586:5819-31. 2008
  10. doi request reprint Endurance training modulates intramyocellular lipid compartmentalization and morphology in skeletal muscle of lean and obese women
    Michaela C Devries
    Departments of Pediatrics and Medicine, McMaster University, Neuromuscular Disease Clinic, Health Sciences Centre, Room 2H26, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    J Clin Endocrinol Metab 98:4852-62. 2013

Detail Information

Publications60

  1. pmc Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance
    Nirupa Sachithanandan
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
    Diabetes 60:2023-31. 2011
    ..In the current study, we investigated the physiological role of myeloid and lymphoid cell SOCS1 in regulating inflammation and insulin sensitivity...
  2. ncbi request reprint AMPK: mediating the metabolic effects of salicylate-based drugs?
    Gregory R Steinberg
    Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario L8N 3Z5, Canada Electronic address
    Trends Endocrinol Metab 24:481-7. 2013
    ..Here we discuss the idea that AMP-activated protein kinase (AMPK) might mediate some effects of salicylate-based drugs, particularly by modulating cellular metabolism. ..
  3. pmc Ciliary neurotrophic factor stimulates muscle glucose uptake by a PI3-kinase-dependent pathway that is impaired with obesity
    Gregory R Steinberg
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Melbourne, Australia
    Diabetes 58:829-39. 2009
    ..CNTF also increases Akt signaling in neurons and adipocytes. Because both Akt and AMPK regulate glucose uptake, we investigated muscle glucose uptake in response to CNTF signaling in lean and obese mice...
  4. doi request reprint Role of the AMP-activated protein kinase in regulating fatty acid metabolism during exercise
    Gregory R Steinberg
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria 3065, Australia
    Appl Physiol Nutr Metab 34:315-22. 2009
    ....
  5. doi request reprint AMPK in Health and Disease
    Gregory R Steinberg
    Protein Chemistry and Metabolism, St Vincent s Institute of Medical Research, University of Melbourne, Fitzroy, Victoria, Australia
    Physiol Rev 89:1025-78. 2009
    ..Lastly, we review the possible role of AMPK in multiple common diseases and the role of the new age of drugs targeting AMPK signaling...
  6. pmc AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance
    Nicolas Dzamko
    Department of Medicine, St Vincent s Institute of Medical Research, University of Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    J Biol Chem 285:115-22. 2010
    ..We demonstrate that the loss of beta1 reduces food intake and protects against the deleterious effects of an obesity-inducing diet...
  7. doi request reprint Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity
    Nirupa Sachithanandan
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
    Hepatology 52:1632-42. 2010
    ..SOCS3 LKO mice fed an HFD also had elevated hypothalamic SOCS3 and fatty acid synthase expression and developed greater obesity due to increased food intake and reduced energy expenditure...
  8. ncbi request reprint The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humans
    Gregory R Steinberg
    St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
    J Clin Endocrinol Metab 91:3592-7. 2006
    ..Human obesity is associated with leptin resistance, and recent studies have demonstrated that hypothalamic expression of the suppressors of cytokine signaling 3 (SOCS3) regulates leptin sensitivity in rodents...
  9. pmc AMPK-independent pathways regulate skeletal muscle fatty acid oxidation
    Nicolas Dzamko
    St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
    J Physiol 586:5819-31. 2008
    ..These data demonstrate that AMPK is not essential for the regulation of fatty acid oxidation by AICAR or muscle contraction...
  10. doi request reprint Endurance training modulates intramyocellular lipid compartmentalization and morphology in skeletal muscle of lean and obese women
    Michaela C Devries
    Departments of Pediatrics and Medicine, McMaster University, Neuromuscular Disease Clinic, Health Sciences Centre, Room 2H26, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    J Clin Endocrinol Metab 98:4852-62. 2013
    ..Endurance training (ET) increases mitochondrial content/activity and IMCL content in young, active men and women. We have previously shown that ET alters the size, number, and physical juxtaposition of IMCLs and mitochondria...
  11. ncbi request reprint Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue
    Matthew J Watt
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, PO Box 71, Bundoora 3083, Victoria, Australia
    Am J Physiol Endocrinol Metab 290:E500-8. 2006
    ..Taken together, these data indicate that HSL activity is maintained in the face of AMPK activation as a result of elevated HSL Ser(660) phosphorylation in adipose tissue but not skeletal muscle...
  12. ncbi request reprint Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese mice
    Gregory R Steinberg
    St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
    Endocrinology 147:3906-14. 2006
    ..A HFD blunted leptin but not CNTF effects on AMPK signaling in the ARC and PVN. In summary, these data demonstrate that CNTF(Ax15) bypasses diet-induced leptin resistance to reduce hypothalamic AMPK activity...
  13. ncbi request reprint PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle
    Robert J Southgate
    Cellular and Molecular Metabolism Laboratory, RMIT University, Bundoora, Victoria, Australia
    FASEB J 19:2072-4. 2005
    ..We conclude that insulin decreases the expression of genes involved in oxidative metabolism in healthy but not insulin resistant muscle, due to a decrease in FoxO1 phosphorylation and nuclear exclusion secondary to reduced Akt activity...
  14. pmc Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity
    Sandra Galic
    St Vincent s Institute of Medical Research, University of Melbourne, Fitzroy, Victoria, Australia
    J Clin Invest 121:4903-15. 2011
    ..Thus, activation of AMPK β1 and increasing fatty acid oxidation in macrophages may represent a new therapeutic approach for the treatment of insulin resistance...
  15. ncbi request reprint Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling
    Gregory R Steinberg
    St Vincent s Institute and Department of Medicine, University of Melbourne, Fitzroy, Vic, 3065, Australia
    Cell Metab 4:465-74. 2006
    ..Our data demonstrate that AMPK is an important TNFalpha signaling target and is a contributing factor to the suppression of fatty-acid oxidation and the development of lipid-induced insulin resistance in obesity...
  16. ncbi request reprint Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
    Morgan D Fullerton
    1 Department of Medicine, Division of Endocrinology and Metabolism, McMaster University, Hamilton, Ontario, Canada 2 Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada 3
    Nat Med 19:1649-54. 2013
    ..These findings establish that inhibitory phosphorylation of Acc by Ampk is essential for the control of lipid metabolism and, in the setting of obesity, for metformin-induced improvements in insulin action. ..
  17. pmc AMP-activated protein kinase (AMPK) beta1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise
    Hayley M O'Neill
    Department of Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5
    Proc Natl Acad Sci U S A 108:16092-7. 2011
    ....
  18. doi request reprint Immunometabolism of AMPK in insulin resistance and atherosclerosis
    Morgan D Fullerton
    Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Mol Cell Endocrinol 366:224-34. 2013
    ..Therefore, the immunometabolism of AMPK-mediated processes and therapeutics should be considered in atherosclerosis and insulin resistance...
  19. pmc Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity
    Sebastian Beck Jorgensen
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
    Diabetes 62:56-64. 2013
    ..Therapies aimed at inhibiting SOCS3 in skeletal muscle may be effective in reversing obesity-related glucose intolerance and insulin resistance...
  20. pmc Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes
    Matthew J Watt
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, Victoria, Australia
    J Physiol 574:139-47. 2006
    ....
  21. ncbi request reprint Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocation
    Sebastian Beck Jørgensen
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia
    Am J Physiol Endocrinol Metab 297:E57-66. 2009
    ..We conclude that resistin impairs insulin-stimulated glucose uptake by mechanisms involving reduced plasma membrane GLUT4 translocation but independent of the proximal insulin-signaling cascade, AMPK, and SOCS-3...
  22. doi request reprint Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARalpha and UCP2 expression in rats
    Anna G Holmes
    Diabetes and Metabolism Division, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Endocrinol 198:367-74. 2008
    ..Our results do not support the notion that prolonged chronically elevated IL-6 impairs insulin action in vivo...
  23. doi request reprint Deficiency in interferon-gamma results in reduced body weight and better glucose tolerance in mice
    Nicole Wong
    University of Melbourne, Department of Medicine Austin Health and Northern Health, Heidelberg Repatriation Hospital, 300 Waterdale Road, Heidelberg Heights, Victoria 3081, Australia
    Endocrinology 152:3690-9. 2011
    ..Our findings demonstrate that IFNγ plays a critical role in the regulation of body weight and glucose metabolism...
  24. pmc Muscle-specific AMPK β1β2-null mice display a myopathy due to loss of capillary density in nonpostural muscles
    Melissa M Thomas
    2Department of Pathology and Molecular Medicine, McMaster University, 1280 Main St West, Hamilton, ON L8S4L8, Canada
    FASEB J 28:2098-107. 2014
    ..S., Criswell, D. S., O'Neill, H. M., Connor, M. K., Anderson, J. E., Kemp, B. E., Steinberg, G. R., and Hawke, T. J. Muscle-specific AMPK β1β2-null mice display a myopathy due to loss of capillary density in nonpostural muscles. ..
  25. doi request reprint Adipose tissue as an endocrine organ
    Sandra Galic
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia
    Mol Cell Endocrinol 316:129-39. 2010
    ....
  26. pmc Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity
    Gregory R Steinberg
    Department of Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Biol Chem 285:37198-209. 2010
    ..In summary these data show that deletion of AMPK β2 reduces AMPK activity in skeletal muscle resulting in impaired exercise capacity and the worsening of diet-induced obesity and glucose intolerance...
  27. doi request reprint AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity
    Hayley M O'Neill
    University of Melbourne, Department of Medicine, St Vincent s Institute of Medical Research, Melbourne, Victoria, Australia
    Mol Cell Endocrinol 366:135-51. 2013
    ....
  28. ncbi request reprint The AMP-activated protein kinase: role in regulation of skeletal muscle metabolism and insulin sensitivity
    Gregory R Steinberg
    St Vincent s Institute of Medical Research, Australia
    Mini Rev Med Chem 7:519-26. 2007
    ....
  29. ncbi request reprint AMP-activated protein kinase--the fat controller of the energy railroad
    Gregory R Steinberg
    St Vincent s Institute, 41 Victoria Pd, Fitzroy, 3065 Victoria, Australia
    Can J Physiol Pharmacol 84:655-65. 2006
    ..As such, it can be considered to be the fat controller of the energy railroad. It is thought that AMPK may be a major mediator of the health benefits of exercise in mitigating the development of obesity and age-onset diseases...
  30. ncbi request reprint Reduced glycogen availability is associated with increased AMPKalpha2 activity, nuclear AMPKalpha2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle
    Gregory R Steinberg
    Vincent s Institute and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
    Appl Physiol Nutr Metab 31:302-12. 2006
    ..We suggest that increased activation of AMPK alpha2 under conditions of low muscle glycogen enhances AMPK alpha2 nuclear translocation and increases GLUT4 mRNA expression in response to exercise in human skeletal muscle...
  31. ncbi request reprint Inflammation in obesity is the common link between defects in fatty acid metabolism and insulin resistance
    Gregory R Steinberg
    St Vincent s Institute, Fitzroy, Victoria, Australia
    Cell Cycle 6:888-94. 2007
    ..1) These data identify a novel mechanism by which inflammation in obesity is a precursor to defects in skeletal muscle fatty acid oxidation that generates a vicious cycle exacerbating the development of insulin resistance...
  32. ncbi request reprint Beta-adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling
    Matthew J Watt
    Skeletal Muscle Research Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology, Bundoora, Victoria, Australia
    FASEB J 18:1445-6. 2004
    ..However, the increased IMTG degradation in LG suggests factors other than HSL activity are important for IMTG degradation...
  33. doi request reprint Low salt concentrations activate AMP-activated protein kinase in mouse macula densa cells
    Natasha Cook
    Dept of Nephrology, Austin Health, Studley Rd, Heidelberg 3084, Victoria, Australia
    Am J Physiol Renal Physiol 296:F801-9. 2009
    ..Phosphorylation of these substrates in vivo is predicted to increase intracellular chloride and so reduce the effect of salt restriction on tubuloglomerular feedback and renin secretion...
  34. ncbi request reprint Socs1 deficiency enhances hepatic insulin signaling
    Emma Jamieson
    St Vincent s Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    J Biol Chem 280:31516-21. 2005
    ..Socs1 deficiency increases IRS-2 expression and enhances hepatic insulin sensitivity in vivo indicating that inhibition of SOCS1 may be a logical strategy in type 2 diabetes...
  35. pmc Enhanced lipid oxidation and maintenance of muscle insulin sensitivity despite glucose intolerance in a diet-induced obesity mouse model
    Karin E Trajcevski
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 8:e71747. 2013
    ..This research investigates the associations between glucose intolerance or muscle insulin resistance and tissue specific changes during the progression of diet-induced obesity...
  36. pmc Markers of skeletal muscle mitochondrial function and lipid accumulation are moderately associated with the homeostasis model assessment index of insulin resistance in obese men
    Imtiaz A Samjoo
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 8:e66322. 2013
    ..25; P = 0.152). Our findings suggest that once physical activity and cardiorespiratory fitness have been controlled for, skeletal muscle mitochondrial and IMCL profile in obesity may only partially contribute to the development of IR...
  37. pmc Loss of TDAG51 results in mature-onset obesity, hepatic steatosis, and insulin resistance by regulating lipogenesis
    Sana Basseri
    Division of Nephrology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Diabetes 62:158-69. 2013
    ..Taken together, our findings suggest that TDAG51 is involved in energy homeostasis at least in part by regulating lipogenesis in liver and WAT, and hence, may constitute a novel therapeutic target for the treatment of obesity and IR...
  38. ncbi request reprint Impaired activation of AMP-kinase and fatty acid oxidation by globular adiponectin in cultured human skeletal muscle of obese type 2 diabetics
    Michael B Chen
    St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
    J Clin Endocrinol Metab 90:3665-72. 2005
    ..These data suggest that reduced activation of AMPK by gAD in obese and obese type 2 diabetic subjects is not caused by reduced adiponectin receptor expression but that aspects downstream of the receptor may inhibit AMPK signaling...
  39. doi request reprint Skeletal muscle glucose uptake during contraction is regulated by nitric oxide and ROS independently of AMPK
    Troy L Merry
    Dept of Physiology, Univ of Melbourne, Victoria, Australia
    Am J Physiol Endocrinol Metab 298:E577-85. 2010
    ..In conclusion, ROS and NO are involved in regulating skeletal muscle glucose uptake during contraction via an AMPK-independent mechanism...
  40. ncbi request reprint Adiponectin: starving for attention
    Gregory R Steinberg
    St Vincent s Institute, Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    Cell Metab 6:3-4. 2007
    ..A new study from the Kadowaki laboratory (Kubota et al., 2007) shows that the adipocyte-derived hormone adiponectin increases appetite and reduces energy expenditure by stimulating AMPK in the hypothalamus...
  41. ncbi request reprint AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice
    Hayley M O'Neill
    Division of Endocrinology and Metabolism, Department of Medicine, HSC 4N63, McMaster University, 1280 Main St West, Hamilton, ON, Canada, L8N 3Z5
    Diabetologia 57:1693-702. 2014
    ....
  42. doi request reprint IL-6 is not essential for exercise-induced increases in glucose uptake
    Hayley M O'Neill
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    J Appl Physiol (1985) 114:1151-7. 2013
    ..These data provide evidence that IL-6 does not play a major role in regulating substrate utilization or skeletal muscle glucose uptake during steady-state endurance exercise...
  43. ncbi request reprint AMP-activated protein kinase is not down-regulated in human skeletal muscle of obese females
    Gregory R Steinberg
    St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria, Australia 3065
    J Clin Endocrinol Metab 89:4575-80. 2004
    ....
  44. ncbi request reprint Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK
    Peter F Mount
    Department of Nephrology, Austin Health, Heidelberg, Victoria, Australia
    Atherosclerosis 200:28-36. 2008
    ..The effect of BK on endothelial lipid metabolism represents a novel pathway for targeting fatty acid mediated endothelial cell dysfunction...
  45. pmc Diacylglycerol kinase delta promotes lipogenesis
    Yulia V Shulga
    Department of Biochemistry and Biomedical Sciences and Division of Endocrinology, Department of Medicine, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    Biochemistry 52:7766-76. 2013
    ..These three enzymes are involved in the synthesis of long chain fatty acids. Our results demonstrate that DGKδ markedly increases lipid synthesis, at least in part as a result of promoting the de novo synthesis of fatty acids...
  46. ncbi request reprint Adipocyte triglyceride lipase expression in human obesity
    Gregory R Steinberg
    St Vincent s Institute, Department of Medicine, The University of Melbourne, Fitzroy, Victoria, Australia
    Am J Physiol Endocrinol Metab 293:E958-64. 2007
    ....
  47. ncbi request reprint Subcellular localization of cyclic AMP-responsive element binding protein-regulated transcription coactivator 2 provides a link between obesity and breast cancer in postmenopausal women
    Kristy A Brown
    Prince Henry s Institute, Monash Medical Centre, Clayton, Victoria, Australia
    Cancer Res 69:5392-9. 2009
    ..In conclusion, the regulation of aromatase by CRTC2, in response to the altered hormonal milieu associated with menopause and obesity, provides a critical link between obesity and breast cancer...
  48. doi request reprint High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus
    Brian G Drew
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Circulation 119:2103-11. 2009
    ..We hypothesized that HDL modulates glucose metabolism via elevation of plasma insulin and through activation of the key metabolic regulatory enzyme, AMP-activated protein kinase, in skeletal muscle...
  49. ncbi request reprint Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity
    Sandra Galic
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, VIC 3065, Australia
    Biochem J 461:177-88. 2014
    ..Lastly, we discuss the important findings from SOCS whole-body and tissue-specific null mice, which implicate an important role for these proteins in controlling insulin action and glucose homoeostasis in obesity. ..
  50. ncbi request reprint Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling
    John W Scott
    Protein Chemistry and Metabolism, St Vincent s Institute of Medical Research, University of Melbourne, 41 Victoria Parade, Fitzroy VIC 3065, Australia Electronic address
    Chem Biol 21:619-27. 2014
    ..These findings have important implications for development of AMPK-targeting therapeutics and point to possible combinatorial therapeutic strategies based on AMP and AMPK drugs. ..
  51. doi request reprint PIKfyve: a new fish in the growing pool of AMPK substrates
    James S V Lally
    Department of Medicine, McMaster University, 1200 Main St W, Hamilton, Ontario, Canada, L8N 3Z5
    Biochem J 455:e1-3. 2013
    ..These data provide compelling evidence for a new AMPK substrate that converges with PKB/Akt signalling and may be critical for the control of glucose uptake in skeletal muscle. ..
  52. ncbi request reprint Cytokine Regulation of AMPK signalling
    Gregory R Steinberg
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia
    Front Biosci (Landmark Ed) 14:1902-16. 2009
    ....
  53. doi request reprint Impact of SOCS3 overexpression on human skeletal muscle development in vitro
    Marissa K Caldow
    Molecular Nutrition Unit, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia
    Cytokine 55:104-9. 2011
    ..Thus SOCS3 influences myoblast differentiation and SOCS3 may be significant in regulating the activity of genes previously identified as transcriptionally regulated by STAT3...
  54. pmc Hepatic Glucose Intolerance Precedes Hepatic Steatosis in the Male Aromatase Knockout (ArKO) Mouse
    Michelle L Van Sinderen
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia
    PLoS ONE 9:e87230. 2014
    ..Therefore, we conclude that male ArKO mice develop hepatic glucose intolerance by the age of 3 months which precedes the sex-specific development of hepatic steatosis. This can be reversed upon the administration of exogenous E2. ..
  55. doi request reprint The long and winding TRAIL to weight loss
    Regje M E Blumer
    Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    Clin Sci (Lond) 123:545-6. 2012
    ..These results suggest that TRAIL could be an exciting new therapeutic for treating obesity, but further studies are required to determine its major mechanisms of action...
  56. pmc Elevated mitochondrial oxidative stress impairs metabolic adaptations to exercise in skeletal muscle
    Justin D Crane
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 8:e81879. 2013
    ....
  57. ncbi request reprint Reduced plasma FFA availability increases net triacylglycerol degradation, but not GPAT or HSL activity, in human skeletal muscle
    Matthew J Watt
    Skeletal Muscle Research Laboratory, School of Medical Sciences, RMIT Univ, PO Box 71, Bundoora 3083, Victoria, Australia
    Am J Physiol Endocrinol Metab 287:E120-7. 2004
    ..These changes in IMTG degradation appear to disassociate, however, from the activity of the key enzymes responsible for synthesis and degradation of this substrate...
  58. ncbi request reprint AMPK promotes macrophage fatty acid oxidative metabolism to mitigate inflammation: implications for diabetes and cardiovascular disease
    Gregory R Steinberg
    1 Faculty of Health Sciences, Department of Medicine, McMaster University, Hamilton, Ontario, Canada 2 Faculty of Health Sciences, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
    Immunol Cell Biol 92:340-5. 2014
    ....
  59. pmc Chronic modulation of AMP-Kinase, Akt and mTOR pathways by ionizing radiation in human lung cancer xenografts
    Yaryna Storozhuk
    Translational Radiation Biology Laboratory, McMaster University, Hamilton, Ontario, Canada
    Radiat Oncol 7:71. 2012
    ..Since the ATM, AMPK and Akt pathways are key targets of novel radio-sensitizing therapeutics, we examined the chronic modultion of expression and activity of those pathways by IR alone in xenograft models of lung cancer...