Arya M Sharma

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi Obesity and cardiovascular risk
    A M Sharma
    Canada Research Chair for Cardiovascular Obesity Research and Management, Department of Medicine, Hamilton General Hospital, McMaster University, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada
    Growth Horm IGF Res 13:S10-7. 2003
  2. ncbi Treatment of obesity: a challenging task
    Arya M Sharma
    Department of Medicine, Cardiovascular Obesity Research and Management at the Michael G deGroote School of Medicine, Hamilton, Canada
    Contrib Nephrol 151:212-20. 2006
  3. ncbi Adipose tissue: a mediator of cardiovascular risk
    A M Sharma
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Int J Obes Relat Metab Disord 26:S5-7. 2002
  4. ncbi [Good blood pressure control even in overweight patients]
    A M Sharma
    Department of Medicine, Michael de Groote School of Medicine, McMaster University, Hamilton General Hospital 237 Barton Street East Hamilton, Ontario L8L 2X2, Canada
    MMW Fortschr Med 147:48. 2005
  5. ncbi The role of renin-angiotensin system blockade in the management of hypertension associated with the cardiometabolic syndrome
    Arya M Sharma
    Michael G deGroote Medical School, McMaster University, Hamilton, Ontario, Canada
    J Cardiometab Syndr 1:29-35. 2006
  6. ncbi Angiotensin blockade prevents type 2 diabetes by formation of fat cells
    Arya M Sharma
    HELIOS Klinikum Berlin, Franz Volhard Clinic Charité, Humboldt University of Berlin, and Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Hypertension 40:609-11. 2002
  7. doi The value of current interventions for obesity
    Arya M Sharma
    Cardiovascular Obesity Research and Management in Michael deGroote School of Medicine, McMaster University, Hamilton, ON, Canada
    Nat Clin Pract Cardiovasc Med 5:S3-9. 2008
  8. ncbi Is there a rationale for angiotensin blockade in the management of obesity hypertension?
    Arya M Sharma
    McMaster University, Hamilton General Hospital, 237 Barton Street East, Hamilton, ON, Canada
    Hypertension 44:12-9. 2004
  9. ncbi High prevalence and poor control of hypertension in primary care: cross-sectional study
    Arya M Sharma
    Franz Volhard Clinic Charité, Berlin, Germany
    J Hypertens 22:479-86. 2004
  10. ncbi Telmisartan in patients with mild/moderate hypertension and chronic kidney disease
    A M Sharma
    University Clinic Benjamin Franklin, Freie Universitat, Berlin
    Clin Nephrol 63:250-7. 2005

Collaborators

Detail Information

Publications119 found, 100 shown here

  1. ncbi Obesity and cardiovascular risk
    A M Sharma
    Canada Research Chair for Cardiovascular Obesity Research and Management, Department of Medicine, Hamilton General Hospital, McMaster University, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada
    Growth Horm IGF Res 13:S10-7. 2003
    ..For moderate overweight and obesity, interventions include dietary modification, increasing physical activity, behavior therapy and pharmacotherapy. Surgery is currently the only viable approach to morbid obesity...
  2. ncbi Treatment of obesity: a challenging task
    Arya M Sharma
    Department of Medicine, Cardiovascular Obesity Research and Management at the Michael G deGroote School of Medicine, Hamilton, Canada
    Contrib Nephrol 151:212-20. 2006
    ..Successful obesity treatment should be defined as long-term weight loss maintenance. In this chapter, we briefly review the current evidences regarding the treatment of obesity...
  3. ncbi Adipose tissue: a mediator of cardiovascular risk
    A M Sharma
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Int J Obes Relat Metab Disord 26:S5-7. 2002
    ..Therefore, abdominal fat deposition, which is characterized by increase in waist circumference, should be the target of clinical intervention in obese individuals...
  4. ncbi [Good blood pressure control even in overweight patients]
    A M Sharma
    Department of Medicine, Michael de Groote School of Medicine, McMaster University, Hamilton General Hospital 237 Barton Street East Hamilton, Ontario L8L 2X2, Canada
    MMW Fortschr Med 147:48. 2005
  5. ncbi The role of renin-angiotensin system blockade in the management of hypertension associated with the cardiometabolic syndrome
    Arya M Sharma
    Michael G deGroote Medical School, McMaster University, Hamilton, Ontario, Canada
    J Cardiometab Syndr 1:29-35. 2006
    ..Randomized, controlled trials conducted specifically in patients with obesity and hypertension are needed to determine the optimal therapeutic approach for these patients...
  6. ncbi Angiotensin blockade prevents type 2 diabetes by formation of fat cells
    Arya M Sharma
    HELIOS Klinikum Berlin, Franz Volhard Clinic Charité, Humboldt University of Berlin, and Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Hypertension 40:609-11. 2002
    ..Increased formation of adipocytes would counteract the ectopic deposition of lipids in other tissues (muscle, liver, pancreas), thereby improving insulin sensitivity and preventing the development of type 2 diabetes...
  7. doi The value of current interventions for obesity
    Arya M Sharma
    Cardiovascular Obesity Research and Management in Michael deGroote School of Medicine, McMaster University, Hamilton, ON, Canada
    Nat Clin Pract Cardiovasc Med 5:S3-9. 2008
    ..If this effect can be demonstrated in humans, this type of agent might become the treatment of choice for obese or overweight people at risk of type 2 diabetes...
  8. ncbi Is there a rationale for angiotensin blockade in the management of obesity hypertension?
    Arya M Sharma
    McMaster University, Hamilton General Hospital, 237 Barton Street East, Hamilton, ON, Canada
    Hypertension 44:12-9. 2004
    ....
  9. ncbi High prevalence and poor control of hypertension in primary care: cross-sectional study
    Arya M Sharma
    Franz Volhard Clinic Charité, Berlin, Germany
    J Hypertens 22:479-86. 2004
    ....
  10. ncbi Telmisartan in patients with mild/moderate hypertension and chronic kidney disease
    A M Sharma
    University Clinic Benjamin Franklin, Freie Universitat, Berlin
    Clin Nephrol 63:250-7. 2005
    ....
  11. ncbi The obese patient with diabetes mellitus: from research targets to treatment options
    Arya M Sharma
    Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Med 119:S17-23. 2006
    ..Clinical trials with telmisartan are currently investigating the effects of RAS blockade on insulin sensitivity in humans...
  12. ncbi The Third International Symposium on Obesity and Hypertension ISOH'03: 'Genetics and Molecular Mechanisms' (October 23-25, 2003, Berlin Germany)
    A M Sharma
    McMaster University, Hamilton, Ontario, Canada
    Int J Obes (Lond) 29:727-34. 2005
    ....
  13. ncbi Obesity, hypertension and insulin resistance
    A M Sharma
    Department of Medicine, McMasterUniversity, Hamilton General Hospital, 237 Barton Street, East Hamilton, Ontario L8L 2X2, Canada
    Acta Diabetol 42:S3-8. 2005
    ....
  14. ncbi Regulating adiponectin: of flax and flux
    A M Sharma
    Michael deGroote School of Medicine, Hamilton General Hospital, McMaster University, 237 Barton East, Hamilton, ON, 2X2 L8L, Canada
    Diabetologia 48:1035-7. 2005
  15. ncbi Paradoxical effect of sibutramine on autonomic cardiovascular regulation in obese hypertensive patients--sibutramine and blood pressure
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Clin Auton Res 15:200-6. 2005
    ..This notion has not been tested in overweight and obese patients...
  16. ncbi Selective impairment in sympathetic vasomotor control with norepinephrine transporter inhibition
    Jens Tank
    Clinical Research Center, HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University, 13125 Berlin, Germany
    Circulation 107:2949-54. 2003
    ..Norepinephrine transporter (NET) inhibition increases the responsiveness to vasoactive medications and attenuates the response to sympathetic stimuli. The phenomenon may be a result of impaired regulation of sympathetic vasomotor tone...
  17. ncbi Weight loss and the renin-angiotensin-aldosterone system
    Stefan Engeli
    Medical Faculty of the Charite, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, HELIOS Klinikum, Berlin, Germany
    Hypertension 45:356-62. 2005
    ..These data suggest that a 5% reduction in body weight can lead to a meaningfully reduced renin-angiotensin-aldosterone system in plasma and adipose tissue, which may contribute to the reduced blood pressure...
  18. ncbi Regulation of 11beta-HSD genes in human adipose tissue: influence of central obesity and weight loss
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Berlin, Germany
    Obes Res 12:9-17. 2004
    ..The aim of this study was to determine whether up-regulation of human adipose 11beta-HSD1 in obesity can also be found at the gene expression level...
  19. ncbi Hemodynamic and metabolic responses to valsartan and atenolol in obese hypertensive patients
    Jens Jordan
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    J Hypertens 23:2313-8. 2005
    ..Treatment recommendations for lean hypertensives may not be simply extrapolated to obese hypertensive persons...
  20. ncbi Weight Loss and Outcomes in Wait-listed, Medically Managed, and Surgically Treated Patients Enrolled in a Population-based Bariatric Program: Prospective Cohort Study
    Raj S Padwal
    Department of Medicine, University of Alberta Alberta Diabetes Institute Department of Surgery and CAMIS Center for the Advancement of Minimally Invasive Surgery, Royal Alexandra Hospital Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, AB, Canada
    Med Care 52:208-15. 2014
    ..Multidisciplinary bariatric care is increasingly being delivered in Canada within publicly funded regional programs. Demand is high, wait lists are long, and clinical effectiveness is unknown...
  21. ncbi Angiotensin type 1 receptor antagonists induce human in-vitro adipogenesis through peroxisome proliferator-activated receptor-gamma activation
    Jurgen Janke
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Berlin, Germany
    J Hypertens 24:1809-16. 2006
    ..In clonal animal cells, certain angiotensin receptor blockers (ARB) activate the peroxisome proliferator-activated receptor-gamma (PPARgamma). The aim of this work was to validate that observation in human cells and humans...
  22. doi Relation of epicardial fat and alanine aminotransferase in subjects with increased visceral fat
    Gianluca Iacobellis
    Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Obesity (Silver Spring) 16:179-83. 2008
    ..However, the potential link between cardiac adiposity, emerging index of visceral adiposity, and fatty liver is still unexplored...
  23. ncbi Catechol-o-methyltransferase and blood pressure in humans
    Jens Jordan
    Franz Volhard Clinical Research Center and Helios Klinikum Berlin, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 106:460-5. 2002
    ..Whether catechol-O-methyltransferase (COMT), the enzyme that metabolizes extraneuronal norepinephrine, contributes to blood pressure regulation in humans is unknown...
  24. ncbi The adipose-tissue renin-angiotensin-aldosterone system: role in the metabolic syndrome?
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic Charité, Department of Nephrology and Hypertension, Humboldt University of Berlin, Wiltberg Strasse 50, Berlin 13125, Germany
    Int J Biochem Cell Biol 35:807-25. 2003
    ....
  25. ncbi Relation of subepicardial adipose tissue to carotid intima-media thickness in patients with human immunodeficiency virus
    Gianluca Iacobellis
    Cardiovascular Obesity Research and Management at the Michael G deGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Cardiol 99:1470-2. 2007
    ..81, p <0.01). In conclusion, this study suggests, for the first time, that epicardial adipose tissue, an index of cardiac adiposity, may be significantly related to subclinical atherosclerosis in HIV-infected patients...
  26. ncbi HYDRA: possible determinants of unsatisfactory hypertension control in German primary care patients
    U Muscha Steckelings
    Center for Cardiovascular Research Institute of Pharmacology and Toxicology, Charite, Berlin, Germany
    Blood Press 13:80-8. 2004
    ..These insights into the causes of unsatisfactory hypertension control may help to direct future educational programmes designed to improve hypertension management specifically to these deficits and thereby to improve control rates...
  27. ncbi Mature adipocytes inhibit in vitro differentiation of human preadipocytes via angiotensin type 1 receptors
    Jurgen Janke
    Max Delbruck Center for Molecular Medicine, HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Berlin, Germany
    Diabetes 51:1699-707. 2002
    ..Because AGT secretion and Ang II generation are characteristic features of adipogenesis, we postulate a paracrine negative-feedback loop that inhibits further recruitment of preadipocytes by maturing adipocytes...
  28. doi Identification and management of cardiometabolic risk in Canada: a position paper by the cardiometabolic risk working group (executive summary)
    Lawrence A Leiter
    St Michael s Hospital, Toronto, Ontario, Canada
    Can J Cardiol 27:124-31. 2011
    ..Health care professionals must also consider ethnicity-related risk factors in order to appropriately evaluate all individuals in their diverse patient populations...
  29. doi A simple prediction rule for all-cause mortality in a cohort eligible for bariatric surgery
    Raj S Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada2Alberta Diabetes Institute, Edmonton, Alberta, Canada
    JAMA Surg 148:1109-15. 2013
    ....
  30. doi Influence of a clinical lifestyle-based weight loss program on the metabolic risk profile of metabolically normal and abnormal obese adults
    Rebecca H Liu
    School of Kinesiology and Health Science, York University, Toronto, ON, Canada
    Obesity (Silver Spring) 21:1533-9. 2013
    ..The effect of a clinically significant WL of 5% on metabolic factors among metabolically normal and abnormal overweight and obese (MNO and MAO) individuals was examined...
  31. pmc Telmisartan/hydrochlorothiazide versus valsartan/hydrochlorothiazide in obese hypertensive patients with type 2 diabetes: the SMOOTH study
    Arya M Sharma
    McMaster University, Hamilton, ON, Canada
    Cardiovasc Diabetol 6:28. 2007
    ....
  32. ncbi Hormonal regulation of the human adipose-tissue renin-angiotensin system: relationship to obesity and hypertension
    Kerstin Gorzelniak
    Helios Klinkum Berlin, Franz Volhard Clinic Charité and Max Delbrück Center for Molecular Medicine, Humboldt University of Berlin, Germany
    J Hypertens 20:965-73. 2002
    ..The aim of this work was to study the expression of renin-angiotensin system genes in adipose tissue of obese hypertensive subjects and the hormonal regulation of these genes...
  33. pmc Prevention of cardiovascular disease: obesity, diabetes and the metabolic syndrome
    Raj S Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Can J Cardiol 26:18C-20C. 2010
    ..Future efforts will need to focus on these factors and pansocietal solutions will be required if&nbsp;success in reversing the population-wide weight increases that have occurred over the past several decades is to be achieved...
  34. ncbi Association between adiponectin and mediators of inflammation in obese women
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Diabetes 52:942-7. 2003
    ....
  35. ncbi European Society of Hypertension Working Group on Obesity: background, aims and perspectives
    Jens Jordan
    Franz Volhard Clinical Research Center and Department of Nephrology, Helios Klinikum Berlin and Medical Faculty of the Charité, Berlin, Germany
    J Hypertens 25:897-900. 2007
  36. ncbi Obesity and cardiovascular disease: pathogenic mechanisms and potential benefits of weight reduction
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Semin Vasc Med 5:25-33. 2005
    ....
  37. ncbi Pressor effect of water drinking in tetraplegic patients may be a spinal reflex
    Jens Tank
    HELIOS Kliniken Berlin, Franz Volhard Cardiovascular Research Center, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Hypertension 41:1234-9. 2003
    ..This observation might suggest that water drinking activates postganglionic sympathetic neurons either directly or through a spinal reflex mechanism...
  38. pmc Adipocyte hypertrophy, fatty liver and metabolic risk factors in South Asians: the Molecular Study of Health and Risk in Ethnic Groups (mol-SHARE)
    Sonia S Anand
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 6:e22112. 2011
    ..We sought to determine if differences in the distribution and characteristics of adipose tissue between South Asians and white Caucasians account for differences in risk factors for cardiovascular disease...
  39. ncbi Regulation of the nitric oxide system in human adipose tissue
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Charite University Medicine in Berlin, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Lipid Res 45:1640-8. 2004
    ..Increased eNOS and iNOS expression in adipocytes and local effects of insulin and Ang II may increase adipose tissue production of NO in obesity...
  40. doi Substantial changes in epicardial fat thickness after weight loss in severely obese subjects
    Gianluca Iacobellis
    1Department of Medicine, Cardiovascular Obesity Research and Management, McMaster University, Hamilton, Ontario, Canada
    Obesity (Silver Spring) 16:1693-7. 2008
    ..Measurement of echocardiographic epicardial fat thickness may provide an additional tool in understanding the metabolic risk associated with variation in fat distribution...
  41. ncbi Paradoxical effect of sibutramine on autonomic cardiovascular regulation
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 106:2459-65. 2002
    ..Norepinephrine reuptake inhibition with sibutramine conceivably could exacerbate arterial hypertension and promote cardiovascular disease...
  42. pmc Health status, quality of life, and satisfaction of patients awaiting multidisciplinary bariatric care
    Raj S Padwal
    Department of Medicine, University of Alberta, 2F1, 26 Walter C, Mackenzie Health Sciences Centre, 8440 112th Street, Edmonton, AB T6G 2B7, Canada
    BMC Health Serv Res 12:139. 2012
    ..Our objective was to examine wait-listed patients' health status and perceptions regarding the consequences of prolonged wait times using a cross-sectional study design nested within a prospective cohort...
  43. ncbi Perivascular adipose tissue promotes vasoconstriction: the role of superoxide anion
    Yu Jing Gao
    Smooth Muscle Research Program and Department of Anaesthesia, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Cardiovasc Res 71:363-73. 2006
    ..In this study, we examined if PVAT releases other vasoactive factors in response to perivascular nerve activation by electrical field stimulation (EFS)...
  44. ncbi Baroreflex buffering and susceptibility to vasoactive drugs
    Jens Jordan
    Franz Volhard Clinical Research Center and HELIOS Klinikum, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 105:1459-64. 2002
    ..Differences in baroreflex function affect the responsiveness to vasoactive medications, particularly baroreflex buffering of blood pressure; however, the magnitude is not known...
  45. doi Effect of gastric bypass surgery on azithromycin oral bioavailability
    Raj S Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Antimicrob Chemother 67:2203-6. 2012
    ..Gastric bypass, a procedure that circumvents the upper gut, may compromise azithromycin plasma levels. We hypothesized that azithromycin concentrations would be reduced following gastric bypass...
  46. ncbi Resistin gene expression in human adipocytes is not related to insulin resistance
    Jurgen Janke
    Franz Volhard Clinic Charité, the Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Obes Res 10:1-5. 2002
    ..Resistin, therefore, has been suggested to play a role in the pathogenesis of insulin resistance...
  47. doi Threshold values of high-risk echocardiographic epicardial fat thickness
    Gianluca Iacobellis
    Department of Medicine, Cardiovascular Obesity Research and Management, McMaster University, Hamilton, Ontario, Canada
    Obesity (Silver Spring) 16:887-92. 2008
    ..In this study, we sought to provide threshold values of echocardiographic epicardial fat thickness associated with metabolic and anthropometric risk factors...
  48. ncbi Epicardial adipose tissue is related to carotid intima-media thickness and visceral adiposity in HIV-infected patients with highly active antiretroviral therapy-associated metabolic syndrome
    Gianluca Iacobellis
    Cardiovascular Obesity Research and Management at the Michael G deGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Curr HIV Res 5:275-9. 2007
    ..Detection of epicardial fat thickness, new index of visceral adiposity in non HIV-infected patients, might be important as diagnostic tool in HIV-infected patients on HAART...
  49. ncbi Moxonidine in the treatment of overweight and obese patients with the metabolic syndrome: a postmarketing surveillance study
    A M Sharma
    McMaster University, Hamilton, ON, Canada
    J Hum Hypertens 18:669-75. 2004
    ..We conclude that moxonidine effectively reduces blood pressure in patients with metabolic syndrome while simultaneously reducing body weight in obese patients...
  50. ncbi Predictors of health-related quality of life in 500 severely obese patients
    Lindsey M Warkentin
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada Alberta Diabetes Institute, Edmonton, Alberta, Canada
    Obesity (Silver Spring) 22:1367-72. 2014
    ..To characterize health-related quality of life (HRQL) impairment in severely obese subjects, using several validated instruments...
  51. pmc Characteristics of the population eligible for and receiving publicly funded bariatric surgery in Canada
    Raj S Padwal
    Department of Medicine, 2F1, 26 Walter C, Mackenzie Health Sciences Centre, University of Alberta, 8440 112th Street, Edmonton, T6G 2B7, Alberta, Canada
    Int J Equity Health 11:54. 2012
    ..The purpose of this study was to quantify and characterize the bariatric surgery-eligible population in Canada in comparison to surgery-ineligible subjects and surgical recipients...
  52. pmc Obesity prevalence from a European perspective: a systematic review
    Anne Berghöfer
    Institute for Social Medicine, Epidemiology and Health Economics, Charite University Medical Center, Berlin, Germany
    BMC Public Health 8:200. 2008
    ..We therefore aimed to identify and discuss current epidemiological data on the prevalence of obesity in European countries...
  53. doi Glycemic index predicts individual glucose responses after self-selected breakfasts in free-living, abdominally obese adults
    Angela M Kochan
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    J Nutr 142:27-32. 2012
    ..In this study, GI was a more important determinant of glycemic response than carbohydrate intake...
  54. ncbi Adipose tissue metabolism and CD11b expression on monocytes in obese hypertensives
    Michael Boschmann
    Franz Volhard Clinical Research Center, Charite Campus Buch, HELIOS Klinikum, Berlin, Germany
    Hypertension 46:130-6. 2005
    ..These findings may be explained in part by monocyte/macrophage infiltration of adipose tissue, which appears to interfere with insulin responsiveness...
  55. doi Urinary sodium and potassium excretion and risk of cardiovascular events
    MARTIN J O'DONNELL
    Population Health Research Institute, Hamilton General Hospital, McMaster University, 237 Barton St E, Third Floor, Hamilton, ON, L8L 2X2, Canada
    JAMA 306:2229-38. 2011
    ..The precise relationship between sodium and potassium intake and cardiovascular (CV) risk remains uncertain, especially in patients with CV disease...
  56. ncbi Can PPARgamma agonists have a role in the management of obesity-related hypertension?
    Vasudhevan T Chetty
    Michael deGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Vascul Pharmacol 45:46-53. 2006
    ..This review will highlight the role of TZDs in various models of hypertension and discuss their potential role in the management of obesity-related hypertension...
  57. ncbi Reduced vagal activity in salt-sensitive subjects during mental challenge
    Konrad Buchholz
    Division of Psychosomatic Medicine, Benjamin Franklin Medical Center, Free University of Berlin, Berlin, Germany
    Am J Hypertens 16:531-6. 2003
    ..Stress-induced HR acceleration may result from sympathetic activation or vagal withdrawal. We studied the importance of vagal withdrawal for the increased stress responsiveness of salt-sensitive subjects...
  58. ncbi Periadventitial fat releases a vascular relaxing factor
    Matthias Löhn
    HELIOS Klinikum Berlin, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    FASEB J 16:1057-63. 2002
    ..We suggest that perivascular adventitial adipose tissue releases a transferable adventitium-derived relaxing factor that acts by tyrosine kinase-dependent activation of K+ channels in vascular smooth muscle cells...
  59. ncbi Angiotensin-converting enzyme inhibition but not beta-adrenergic blockade limits transforming growth factor-beta overexpression in acute normotensive anti-thy1 glomerulonephritis
    Harm Peters
    Division of Nephrology, Charite, Campus Mitte, Humboldt University, Berlin, Germany
    J Hypertens 21:771-80. 2003
    ....
  60. ncbi Management of hypertension in overweight and obese patients: a practical guide for clinicians
    Francesco Dentali
    St Joseph s Hospital, Room F 541, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
    Curr Hypertens Rep 7:330-6. 2005
    ..Additional studies to further clarify the management of these patients are warranted...
  61. ncbi Salt sensitivity, anxiety, and irritability predict blood pressure increase over five years in healthy males
    Hans Christian Deter
    Department of Psychosomatic Medicine and Psychotherapy, Benjamin Franklin Medical Center, Free University of Berlin, Berlin, Germany
    Clin Exp Hypertens 28:17-27. 2006
    ..009) and 58% (diastolic ABP, p < 0.0001) of variance. We concluded that anxiety and irritability are important predictors of blood pressure increase over time in healthy males...
  62. pmc The Alberta population-based prospective evaluation of the quality of life outcomes and economic impact of bariatric surgery (APPLES) study: background, design and rationale
    Raj S Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    BMC Health Serv Res 10:284. 2010
    ..We hypothesize that lower indirect, out of pocket and productivity costs will offset increased direct health-care costs resulting in lower total costs for bariatric surgery...
  63. ncbi Epicardial adipose tissue as new cardio-metabolic risk marker and potential therapeutic target in the metabolic syndrome
    Gianluca Iacobellis
    Department of Medicine, Cardiovascular Obesity Research and Management, McMaster University Hamilton, Ontario, Canada
    Curr Pharm Des 13:2180-4. 2007
    ..In this article, epicardial adipose tissue's structure, function, method of assessment and reliability as a diagnostic tool and potential therapeutic target is reviewed...
  64. ncbi Heterogeneity of autonomic regulation in hypertension and neurovascular contact
    Jens Jordan
    HELIOS Klinikum Berlin, Franz Volhard Clinic and Clinical Research Center, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    J Hypertens 20:701-6. 2002
    ..We tested the hypothesis that similar abnormalities are present in patients with essential hypertension who have NVC...
  65. ncbi A gene expression analysis in rat kidney following high and low salt intake
    Peter Barta
    Max Delbruck Center for Molecular Medicine, Humboldt University of Berlin, Berlin, Germany
    J Hypertens 20:1115-20. 2002
    ..The effects of salt intake on renal regulation have been investigated for decades. To find new pathways and to demonstrate the utility of oligonucleotide expression arrays, we studied whole kidneys...
  66. ncbi Serum- and glucocorticoid-regulated kinase (SGK1) gene and blood pressure
    Andreas Busjahn
    Franz Volhard Clinic, HELIOS Kliniken Berlin and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Hypertension 40:256-60. 2002
    ..This combined effect of the polymorphisms was confirmed in an independent sample of 260 young normotensive men. We conclude that the SGK1 gene is relevant to blood pressure regulation and probably to hypertension in man...
  67. pmc Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance
    Andrew Mente
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 33:1629-34. 2010
    ..To investigate ethnic differences in adiponectin and leptin concentration and to determine whether these adipokines and a high-glycemic index diet account for ethnic variation in insulin resistance...
  68. ncbi The management of hypertension in the overweight and obese patient: is weight reduction sufficient?
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Drugs 64:795-803. 2004
    ..Additional studies are needed to determine the long-term (>1 year) efficacy and safety of antihypertensive and anti-obesity management strategies in the overweight and obese hypertensive patient...
  69. ncbi The BK channel beta1 subunit gene is associated with human baroreflex and blood pressure regulation
    Maik Gollasch
    HELIOS Klinikum Berlin Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    J Hypertens 20:927-33. 2002
    ..We tested the hypothesis that variants in the gene (KCNMB1) coding for the BK beta1 subunit are associated with baroreflex function...
  70. ncbi Influence of Sibutramine on blood pressure: evidence from placebo-controlled trials
    J Jordan
    Franz Volhard Clinical Research Center and HELIOS Klinikum, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Int J Obes (Lond) 29:509-16. 2005
    ..Sibutramine, a serotonin and norepinephrine transporter inhibitor, is widely used as an adjunctive obesity treatment. There have been concerns that norepinephrine reuptake inhibition with sibutramine could exacerbate arterial hypertension...
  71. pmc Effect of gastric bypass surgery on the absorption and bioavailability of metformin
    Raj S Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Diabetes Care 34:1295-300. 2011
    ..Metformin, the first-line drug for diabetes, has low bioavailability and slow, incomplete gastrointestinal absorption. We hypothesized that gastric bypass would further reduce the absorption and bioavailability of metformin...
  72. ncbi Emergency department equipment for obese patients: perceptions of adequacy
    Navneet Singh
    Honours Program Cardiovascular Obesity Research and Management, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    J Adv Nurs 59:140-5. 2007
    ....
  73. ncbi The relationship of body mass index to outcomes after percutaneous coronary intervention
    Mamdouh M Shubair
    Department of Medicine, McMaster University, Hamilton Health Sciences General Site, Hamilton, Ontario, Canada
    J Interv Cardiol 19:388-95. 2006
    ..To evaluate the effect of body mass index (BMI) on in-hospital outcomes in patients undergoing percutaneous coronary intervention (PCI) at a tertiary care hospital center in Ontario, Canada...
  74. ncbi Perivascular adipose tissue modulates vascular function in the human internal thoracic artery
    Yu Jing Gao
    Department of Anaesthesia, McMaster University, Hamilton, Ontario, Canada
    J Thorac Cardiovasc Surg 130:1130-6. 2005
    ..The purpose of the present study was to examine whether this vasodilator is also present in human internal thoracic arteries...
  75. ncbi Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada
    Lancet 366:1640-9. 2005
    ..We aimed to assess whether markers of obesity, especially waist-to-hip ratio, would be stronger indicators of myocardial infarction than body-mass index (BMI), the conventional measure...
  76. ncbi Do cardiac and perivascular adipose tissue play a role in atherosclerosis?
    Gianluca Iacobellis
    Department of Medicine, St Joseph s Hospital, 50 Charlton Avenue East, 5th Fontbonne Building, Hamilton, Ontario, L8N 4A6, Canada
    Curr Diab Rep 8:20-4. 2008
    ..The double role of epicardial and perivascular adipose tissue in the development of cardiovascular pathology and/or in protecting the heart and arteries warrants further studies...
  77. ncbi A patient with personal control of the adjustable gastric band and bulimia: a psychiatric complication
    Valerie H Taylor
    Mood Disorders Program, Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, Canada
    Obes Surg 16:1386-7. 2006
    ..Self-adjustment of the gastric band for control of intake is a potential problem. Preoperative psychiatric evaluation is desirable to identify and treat eating disorders and depression, and to indicate surveillance...
  78. pmc Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide
    Y J Gao
    Department of Anesthesia, Smooth Muscle Research Program, McMaster University, Hamilton, Ontario, Canada
    Br J Pharmacol 151:323-31. 2007
    ..Perivascular adipose tissue (PVAT) attenuates vascular contraction, but the mechanisms remain largely unknown. The possible involvement of endothelium (E) and hydrogen peroxide (H2O2) was investigated...
  79. ncbi The effect of oral glucose loads on tissue metabolism during angiotensin II receptor and beta-receptor blockade in obese hypertensive subjects
    M Boschmann
    Franz Volhard Clinical Research Center, Charité Campus Buch and HELIOS Klinikum, Berlin, Berlin, Germany
    Horm Metab Res 38:323-9. 2006
    ..The exact mechanism by which inhibition of the renin-angiotensin-aldosterone system decreases the diabetes risk remains unresolved and requires further study...
  80. ncbi Metabolic profile and exercise capacity outcomes: their relationship to overweight and obesity in a Canadian cardiac rehabilitation setting
    Mamdouh M Shubair
    Department of Medicine, McMaster University, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada
    J Cardiopulm Rehabil 24:405-13. 2004
    ....
  81. ncbi Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart
    Gianluca Iacobellis
    Department of Medicine, Cardiovascular Obesity Research and Management, Michael G DeGroote School of Medicine, Hamilton, Ontario, Canada
    Nat Clin Pract Cardiovasc Med 2:536-43. 2005
    ..In this paper, we briefly review the rapidly emerging evidence pointing to a specific role of epicardial adipose tissue both as a cardiac risk marker and as a potentially active player in the development of cardiac pathology...
  82. ncbi Different "weight" of cardiac and general adiposity in predicting left ventricle morphology
    Gianluca Iacobellis
    Department of Medicine, Cardiovascular Obesity Research and Management, Michael G DeGroote School of Medicine, Hamilton, Ontario, Canada
    Obesity (Silver Spring) 14:1679-84. 2006
    ..Nevertheless, the close anatomical and functional relationship of epicardial adipose tissue to the adjacent myocardium should readily allow local, paracrine interactions between these tissues...
  83. ncbi Sibutramine in overweight/obese hypertensive patients
    A M Sharma
    Franz Volhard Clinic Charité, Nephrology and Hypertension, Berlin, Germany
    Int J Obes Relat Metab Disord 25:S20-3. 2001
    ..Studies have shown that in the obese, well-controlled hypertensive patient, sibutramine is a safe and well-tolerated therapy offering the many clinical benefits associated with weight reduction in this high-risk population...
  84. ncbi Use of beta-blockers in obesity hypertension: potential role of weight gain
    T Pischon
    , Berlin, Germany
    Obes Rev 2:275-80. 2001
    ..We therefore question the use of beta-blockers as first-line therapy for overweight or obese patients with uncomplicated hypertension...
  85. ncbi Choice of drug treatment for obesity-related hypertension: where is the evidence?
    A M Sharma
    Franz Volhard Klinik, Max Delbruck Centre for Molecular Medicine, Berlin, Germany
    J Hypertens 19:667-74. 2001
    ....
  86. ncbi Obesity and the heart: redefinition of the relationship
    G Iacobellis
    Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton General Hospital, Hamilton, ON, Canada
    Obes Rev 8:35-9. 2007
    ....
  87. ncbi The renin-angiotensin system and natriuretic peptides in obesity-associated hypertension
    S Engeli
    Department of Nephrology and Hypertension, Franz-Volhard-Klinik, , , Berlin, Germany
    J Mol Med 79:21-9. 2001
    ..In this paper we review the role of these factors in the development of obesity-associated hypertension, thereby focusing on the potential role of adipose tissue in these alterations...
  88. ncbi Ethnic origin determines the impact of genetic variants in dopamine receptor gene (DRD1) concerning essential hypertension
    Joachim Beige
    Department of Nephrology, Charite, Berlin, Germany
    Am J Hypertens 17:1184-7. 2004
    ..Thus, racial differences may play an important role concerning the association of variants in the dopamine receptor type 1 gene with essential hypertension...
  89. doi Barriers to obesity treatment
    Marina Mauro
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Eur J Intern Med 19:173-80. 2008
    ..Failure to do so may further undermine the sense of failure, low self esteem and self efficacy already common among obese individuals. Addressing treatment barriers can save resources and increase the prospect of long-term success...
  90. ncbi Obesity research in Canada: literature overview of the last 3 decades
    Hanan B Sokar-Todd
    Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2
    Obes Res 12:1547-53. 2004
    ..To identify research published on obesity in Canada, to explore the range of areas studied, and to identify gaps and areas that merit future research attention...
  91. ncbi Neurovascular contact and blood pressure response in young, healthy, normotensive men
    Henriette Hohenbleicher
    Department of Internal Medicine, Division of Endocrinology and Nephrology, Universitatsklinikum Benjamin Franklin, Berlin, Germany
    Am J Hypertens 15:119-24. 2002
    ..We also studied blood pressure, heart rate reactivity, and changes in baroreflex sensitivity in response to mental and physical stress in a subset of subjects with positive and negative brainstem findings...
  92. ncbi Review: Peroxisome proliferator-activated receptor gamma and adipose tissue--understanding obesity-related changes in regulation of lipid and glucose metabolism
    Arya M Sharma
    Canada Research Chair for Cardiovascular Obesity Research and Management, McMaster University, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2
    J Clin Endocrinol Metab 92:386-95. 2007
    ..e. adipocytes display morphological differences alongside aberrant endocrine and metabolic function and low-grade inflammation)...
  93. pmc Managing weighty issues on lean evidence: the challenges of bariatric medicine
    Arya M Sharma
    Cardiovascular Obesity Research and Management, McMaster University, Hamilton, Ont
    CMAJ 172:30-1. 2005
  94. ncbi Obesity is a sign - over-eating is a symptom: an aetiological framework for the assessment and management of obesity
    A M Sharma
    Department of Medicine, University of Alberta, Royal Alexandra Hospital, Edmonton, AB AB T5H 3V9, Canada
    Obes Rev 11:362-70. 2010
    ....
  95. ncbi Limited effect of systemic beta-blockade on sympathetic outflow
    J Tank
    Clinical Research Center, HELIOS Kliniken, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Hypertension 38:1377-81. 2001
    ..This, observation is not consistent with an important tonic stimulatory effect of beta-adrenoreceptors in the brain...
  96. ncbi Hypothesis: Beta-adrenergic receptor blockers and weight gain: A systematic analysis
    A M Sharma
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Hypertension 37:250-4. 2001
    ..Based on these observations, the first-line use of beta-blockers in obese hypertensive patients should be reviewed. Obesity management in overweight hypertensive patients may be more difficult in the face of beta-blocker treatment...
  97. ncbi Enhanced affective startle modulation in salt-sensitive subjects
    K Buchholz
    Division of Psychosomatic Medicine, Benjamin Franklin Medical Center, , Berlin, Germany
    Hypertension 38:1325-9. 2001
    ..This enhanced central nervous responsiveness may contribute to higher sympathetic pressor reactivity and, thus, to the later development of hypertension in salt-sensitive individuals...
  98. ncbi Tumor necrosis factor-alpha--308 G/A polymorphism in obese Caucasians
    E Brand
    Department of Internal Medicine, Division of Endocrinology and Nephrology, Universitätsklinkum Benjamin Franklin, Freie Universitat Berlin, Berlin, Germany
    Int J Obes Relat Metab Disord 25:581-5. 2001
    ..We, therefore, examined the relationship between this variant and obesity in a German Caucasian population...
  99. doi A proposed clinical staging system for obesity
    A M Sharma
    Division of Endocrinology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Int J Obes (Lond) 33:289-95. 2009
    ..It is anticipated that this system, when used together with the present anthropometric classification, will provide a simple framework to aid decision making in clinical practice...
  100. ncbi Adipose tissue and circulating endothelial cell specific molecule-1 in human obesity
    J Janke
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Germany
    Horm Metab Res 38:28-33. 2006
    ..Circulating ESM-1 levels are reduced in the overweight and obese, consistent with the notion that ESM-1 may play some role in obesity-associated vascular disease...
  101. ncbi Computational analysis of blood volume curves and risk of intradialytic morbid events in hemodialysis
    J Beige
    Department of Internal Medicine, Division of Endocrinology and Nephrology, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Berlin, Germany
    Kidney Int 58:1805-9. 2000
    ..The present study therefore deals with a computer-aided analysis of indices characterizing both BV reduction per time and BV variability in treatments of nonselected maintenance hemodialysis patients...