R Sehmi

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. pmc Allergen-induced fluctuation in CC chemokine receptor 3 expression on bone marrow CD34+ cells from asthmatic subjects: significance for mobilization of haemopoietic progenitor cells in allergic inflammation
    Roma Sehmi
    Firestone Institute of Respiratory Health, Asthma Research Group, St Joseph s Healthcare, Divisions of Clinical Immunology, McMaster University, Hamilton, Ontario, Canada
    Immunology 109:536-46. 2003
  2. ncbi request reprint Hemopoietic progenitor cells and hemopoietic factors: potential targets for treatment of allergic inflammatory diseases
    R Sehmi
    Department of Medicine, HSC 3V46, McMaster University, 1200 Main St West, Hamilton, ON L8N 3Z5, Canada
    Curr Drug Targets Inflamm Allergy 2:271-8. 2003
  3. ncbi request reprint Bone marrow contribution to eosinophilic inflammation
    J A Denburg
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Mem Inst Oswaldo Cruz 92:33-5. 1997
  4. doi request reprint Interleukin-4 and interleukin-13 prime migrational responses of haemopoietic progenitor cells to stromal cell-derived factor-1α
    N Punia
    Firestone Institute for Respiratory Health, Asthma Research Group, St Joseph s Healthcare, Hamilton, ON, Canada
    Clin Exp Allergy 42:255-64. 2012
  5. ncbi request reprint Regulation of IL-5 receptor on eosinophil progenitors in allergic inflammation: role of retinoic acid
    J A Denburg
    Department of Medicine, McMaster University, Hamilton, Ont, Canada
    Int Arch Allergy Immunol 124:246-8. 2001
  6. ncbi request reprint Bone marrow progenitors in allergic airways diseases: studies in canine and human models
    J A Denburg
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Int Arch Allergy Immunol 113:181-3. 1997
  7. doi request reprint Modulating progenitor accumulation attenuates lung angiogenesis in a mouse model of asthma
    T M Doyle
    Firestone Institute for Respiratory Health, St Joseph s Hospital, Hamilton, ON, Canada
    Eur Respir J 38:679-87. 2011
  8. ncbi request reprint Hemopoietic mechanisms in allergic airway inflammation
    J A Denburg
    Department of Medicine, McMaster University, Hamilton, Ont, Canada
    Int Arch Allergy Immunol 117:155-9. 1998
  9. ncbi request reprint Regulation of IL-5 and IL-5 receptor expression in the bone marrow of allergic asthmatics
    J A Denburg
    Asthma Research Group, Division of Clinical Immunology and Allergy, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Int Arch Allergy Immunol 118:101-3. 1999
  10. doi request reprint Human airway smooth muscle promotes eosinophil differentiation
    A I Fanat
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare, Department of Medicine, McMaster University, Hamilton, ON, Canada
    Clin Exp Allergy 39:1009-17. 2009

Collaborators

Detail Information

Publications24

  1. pmc Allergen-induced fluctuation in CC chemokine receptor 3 expression on bone marrow CD34+ cells from asthmatic subjects: significance for mobilization of haemopoietic progenitor cells in allergic inflammation
    Roma Sehmi
    Firestone Institute of Respiratory Health, Asthma Research Group, St Joseph s Healthcare, Divisions of Clinical Immunology, McMaster University, Hamilton, Ontario, Canada
    Immunology 109:536-46. 2003
    ....
  2. ncbi request reprint Hemopoietic progenitor cells and hemopoietic factors: potential targets for treatment of allergic inflammatory diseases
    R Sehmi
    Department of Medicine, HSC 3V46, McMaster University, 1200 Main St West, Hamilton, ON L8N 3Z5, Canada
    Curr Drug Targets Inflamm Allergy 2:271-8. 2003
    ..In addition, we will address the potential role that small molecular weight chemokine receptor antagonists may play in modulating progenitor cell trafficking to tissue sites of inflammation...
  3. ncbi request reprint Bone marrow contribution to eosinophilic inflammation
    J A Denburg
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Mem Inst Oswaldo Cruz 92:33-5. 1997
    ..The possibility that there is constitutive marrow upregulation of eosinophilopoiesis in allergic airways disease is also an area for future investigation...
  4. doi request reprint Interleukin-4 and interleukin-13 prime migrational responses of haemopoietic progenitor cells to stromal cell-derived factor-1α
    N Punia
    Firestone Institute for Respiratory Health, Asthma Research Group, St Joseph s Healthcare, Hamilton, ON, Canada
    Clin Exp Allergy 42:255-64. 2012
    ..Factors that modulate the increased traffic of progenitor cells to the site of inflammation in asthma remain to be defined. Interleukin (IL)-4 and IL-13 are Th2 cytokines that are key regulators of asthma pathology...
  5. ncbi request reprint Regulation of IL-5 receptor on eosinophil progenitors in allergic inflammation: role of retinoic acid
    J A Denburg
    Department of Medicine, McMaster University, Hamilton, Ont, Canada
    Int Arch Allergy Immunol 124:246-8. 2001
    ..ATRA may be of therapeutic benefit in allergic inflammatory disorders in which eosinophil differentiation and membrane-bound IL-5R are upregulated...
  6. ncbi request reprint Bone marrow progenitors in allergic airways diseases: studies in canine and human models
    J A Denburg
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Int Arch Allergy Immunol 113:181-3. 1997
    ..Further studies to characterize the serum hematopoietic factor(s) and to determine the nature of any atopy-related progenitor profile are in progress...
  7. doi request reprint Modulating progenitor accumulation attenuates lung angiogenesis in a mouse model of asthma
    T M Doyle
    Firestone Institute for Respiratory Health, St Joseph s Hospital, Hamilton, ON, Canada
    Eur Respir J 38:679-87. 2011
    ..Progenitor lung homing is associated with the development of asthma pathology, and early modulation of this accumulation can prevent airway remodelling and lung dysfunction...
  8. ncbi request reprint Hemopoietic mechanisms in allergic airway inflammation
    J A Denburg
    Department of Medicine, McMaster University, Hamilton, Ont, Canada
    Int Arch Allergy Immunol 117:155-9. 1998
    ..Understanding the signalling between the tissue and the bone marrow at the molecular level may well open up new avenues of therapy for allergic inflammation...
  9. ncbi request reprint Regulation of IL-5 and IL-5 receptor expression in the bone marrow of allergic asthmatics
    J A Denburg
    Asthma Research Group, Division of Clinical Immunology and Allergy, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Int Arch Allergy Immunol 118:101-3. 1999
    ....
  10. doi request reprint Human airway smooth muscle promotes eosinophil differentiation
    A I Fanat
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare, Department of Medicine, McMaster University, Hamilton, ON, Canada
    Clin Exp Allergy 39:1009-17. 2009
    ..Human airway smooth muscle (HASM) cells in culture synthesize cytokines and chemokines that may orchestrate the tissue homing and in situ differentiation of haemopoietic progenitor cells from the peripheral circulation...
  11. ncbi request reprint Fish oil supplementation in pregnancy modifies neonatal progenitors at birth in infants at risk of atopy
    Judah A Denburg
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Pediatr Res 57:276-81. 2005
    ..Dietary n-3 PUFA supplementation during pregnancy in atopic mothers alters infant cord blood hemopoietic progenitor phenotype. This may have an impact on development of atopic disease...
  12. ncbi request reprint Increased eosinophil-lineage committed progenitors in the lung of allergen-challenged mice
    David S Southam
    Firestone Institute for Respiratory Health, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 115:95-102. 2005
    ..However, the isolation and detailed phenotyping of true CD34 + progenitors from lung tissue during an allergen-induced airway eosinophilia has not been performed...
  13. ncbi request reprint Pathogenesis of murine experimental allergic rhinitis: a study of local and systemic consequences of IL-5 deficiency
    Hiroko Saito
    Asthma Research Group, Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Immunol 168:3017-23. 2002
    ....
  14. ncbi request reprint Progenitor egress from the bone marrow after allergen challenge: role of stromal cell-derived factor 1alpha and eotaxin
    Sandra C Dorman
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 115:501-7. 2005
    ..CCR3 expression on CD34+ cells mediates migration to eotaxin in vitro. CXCR4 and stromal cell-derived factor (SDF)-1alpha are important for stem cell homing to hemopoietic compartments...
  15. doi request reprint Cord blood hemopoietic progenitor profiles predict acute respiratory symptoms in infancy
    Rochelle Fernandes
    Division of Allergy and Clinical Immunology, McMaster University, Hamilton, ON, Canada
    Pediatr Allergy Immunol 19:239-47. 2008
    ..The elevation of IL-3/GM-CSF-responsive Eo/B progenitors in high-risk infants in relation to ARI outcomes suggests a mechanism for the increased severity of inflammatory responses in these subjects following viral infection...
  16. ncbi request reprint T-cell-mediated inflammation does not contribute to the maintenance of airway dysfunction in mice
    Richard Leigh
    Firestone Institute for Respiratory Health, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Appl Physiol 97:2258-65. 2004
    ..These results indicate that T-cell-mediated inflammation is critical for development of AHR associated with brief allergen exposure, but is not necessary to maintain sustained AHR...
  17. ncbi request reprint The effect of pranlukast on allergen-induced bone marrow eosinophilopoiesis in subjects with asthma
    Krishnan Parameswaran
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 169:915-20. 2004
    ..We conclude that, the cysteinyl leukotriene receptor antagonist, pranlukast, attenuates allergen-induced increase in airway eosinophils by decreasing bone marrow eosinophilopoiesis and airway chemotactic and eosinophilopoietic cytokines...
  18. ncbi request reprint Retinoic acid modulates IL-5 receptor expression and selectively inhibits eosinophil-basophil differentiation of hemopoietic progenitor cells
    John W Upham
    Department of Medicine, University of Western Australia, Perth, Australia
    J Allergy Clin Immunol 109:307-13. 2002
    ..Currently, little is known concerning regulation of IL-5Ralpha expression in the context of commitment of hemopoietic progenitor cells to the eosinophil and basophil lineages...
  19. ncbi request reprint Sputum CD34+IL-5Ralpha+ cells increase after allergen: evidence for in situ eosinophilopoiesis
    Sandra C Dorman
    Firestone Institute of Respiratory Health, Asthma Research Group, St Joseph s Healthcare, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 169:573-7. 2004
    ..These results indicate that eosinophil progenitors can migrate to the airways and may differentiate toward an eosinophilic phenotype...
  20. ncbi request reprint Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics
    Andrew Menzies-Gow
    Allergy and Clinical Immunology, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London
    J Allergy Clin Immunol 111:714-9. 2003
    ..We have previously reported that anti-IL-5 monoclonal antibody treatment decreases total bone marrow and bronchial mucosal eosinophil numbers in asthma...
  21. ncbi request reprint Allergen-induced increases in bone marrow T lymphocytes and interleukin-5 expression in subjects with asthma
    Lorna J Wood
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Hospital and the Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 166:883-9. 2002
    ....
  22. ncbi request reprint Anti-allergic therapies: effects on eosinophil progenitors
    Adrian J Baatjes
    Asthma Research Group, Department of Medicine, Division of Allergy and Clinical Immunology, HSC 3V46, Canada
    Pharmacol Ther 95:63-72. 2002
    ..Therefore, targeting the systemic hematopoietic response may provide additional, more beneficial, therapeutic effects...
  23. ncbi request reprint Kinetics of bone marrow eosinophilopoiesis and associated cytokines after allergen inhalation
    Sandra C Dorman
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 169:565-72. 2004
    ..We propose that after allergen inhalation, time-dependent changes in cytokine levels in the bone marrow control differentiation of eosinophil/basophil progenitors...
  24. ncbi request reprint Cysteinyl leukotrienes promote human airway smooth muscle migration
    Krishnan Parameswaran
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 166:738-42. 2002
    ..The phosphatidylinositol-3 kinase pathway is a key signaling mechanism in the chemotactic migration of ASM cells in response to cysteinyl leukotrienes...