Research Topics
| R SehmiSummaryAffiliation: McMaster University Country: Canada Publications
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Detail Information
Publications
Allergen-induced fluctuation in CC chemokine receptor 3 expression on bone marrow CD34+ cells from asthmatic subjects: significance for mobilization of haemopoietic progenitor cells in allergic inflammationRoma Sehmi
Firestone Institute of Respiratory Health, Asthma Research Group, St Joseph s Healthcare, Divisions of Clinical Immunology, McMaster University, Hamilton, Ontario, Canada
Immunology 109:536-46. 2003....
Hemopoietic progenitor cells and hemopoietic factors: potential targets for treatment of allergic inflammatory diseasesR Sehmi
Department of Medicine, HSC 3V46, McMaster University, 1200 Main St West, Hamilton, ON L8N 3Z5, Canada
Curr Drug Targets Inflamm Allergy 2:271-8. 2003..In addition, we will address the potential role that small molecular weight chemokine receptor antagonists may play in modulating progenitor cell trafficking to tissue sites of inflammation...- Bone marrow contribution to eosinophilic inflammationJ A Denburg
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Mem Inst Oswaldo Cruz 92:33-5. 1997..The possibility that there is constitutive marrow upregulation of eosinophilopoiesis in allergic airways disease is also an area for future investigation... 
Interleukin-4 and interleukin-13 prime migrational responses of haemopoietic progenitor cells to stromal cell-derived factor-1αN Punia
Firestone Institute for Respiratory Health, Asthma Research Group, St Joseph s Healthcare, Hamilton, ON, Canada
Clin Exp Allergy 42:255-64. 2012..Factors that modulate the increased traffic of progenitor cells to the site of inflammation in asthma remain to be defined. Interleukin (IL)-4 and IL-13 are Th2 cytokines that are key regulators of asthma pathology...- Regulation of IL-5 receptor on eosinophil progenitors in allergic inflammation: role of retinoic acidJ A Denburg
Department of Medicine, McMaster University, Hamilton, Ont, Canada
Int Arch Allergy Immunol 124:246-8. 2001..ATRA may be of therapeutic benefit in allergic inflammatory disorders in which eosinophil differentiation and membrane-bound IL-5R are upregulated... - Bone marrow progenitors in allergic airways diseases: studies in canine and human modelsJ A Denburg
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Int Arch Allergy Immunol 113:181-3. 1997..Further studies to characterize the serum hematopoietic factor(s) and to determine the nature of any atopy-related progenitor profile are in progress... - Modulating progenitor accumulation attenuates lung angiogenesis in a mouse model of asthmaT M Doyle
Firestone Institute for Respiratory Health, St Joseph s Hospital, Hamilton, ON, Canada
Eur Respir J 38:679-87. 2011..Progenitor lung homing is associated with the development of asthma pathology, and early modulation of this accumulation can prevent airway remodelling and lung dysfunction... - Hemopoietic mechanisms in allergic airway inflammationJ A Denburg
Department of Medicine, McMaster University, Hamilton, Ont, Canada
Int Arch Allergy Immunol 117:155-9. 1998..Understanding the signalling between the tissue and the bone marrow at the molecular level may well open up new avenues of therapy for allergic inflammation... - Regulation of IL-5 and IL-5 receptor expression in the bone marrow of allergic asthmaticsJ A Denburg
Asthma Research Group, Division of Clinical Immunology and Allergy, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
Int Arch Allergy Immunol 118:101-3. 1999.... - Human airway smooth muscle promotes eosinophil differentiationA I Fanat
Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare, Department of Medicine, McMaster University, Hamilton, ON, Canada
Clin Exp Allergy 39:1009-17. 2009..Human airway smooth muscle (HASM) cells in culture synthesize cytokines and chemokines that may orchestrate the tissue homing and in situ differentiation of haemopoietic progenitor cells from the peripheral circulation... - Fish oil supplementation in pregnancy modifies neonatal progenitors at birth in infants at risk of atopyJudah A Denburg
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Pediatr Res 57:276-81. 2005..Dietary n-3 PUFA supplementation during pregnancy in atopic mothers alters infant cord blood hemopoietic progenitor phenotype. This may have an impact on development of atopic disease... - Increased eosinophil-lineage committed progenitors in the lung of allergen-challenged miceDavid S Southam
Firestone Institute for Respiratory Health, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
J Allergy Clin Immunol 115:95-102. 2005.... - Pathogenesis of murine experimental allergic rhinitis: a study of local and systemic consequences of IL-5 deficiencyHiroko Saito
Asthma Research Group, Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
J Immunol 168:3017-23. 2002.... - Progenitor egress from the bone marrow after allergen challenge: role of stromal cell-derived factor 1alpha and eotaxinSandra C Dorman
Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph's Healthcare, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
J Allergy Clin Immunol 115:501-7. 2005.... - Cord blood hemopoietic progenitor profiles predict acute respiratory symptoms in infancyRochelle Fernandes
Division of Allergy and Clinical Immunology, McMaster University, Hamilton, ON, Canada
Pediatr Allergy Immunol 19:239-47. 2008..The elevation of IL-3/GM-CSF-responsive Eo/B progenitors in high-risk infants in relation to ARI outcomes suggests a mechanism for the increased severity of inflammatory responses in these subjects following viral infection... - T-cell-mediated inflammation does not contribute to the maintenance of airway dysfunction in miceRichard Leigh
Firestone Institute for Respiratory Health, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
J Appl Physiol 97:2258-65. 2004..These results indicate that T-cell-mediated inflammation is critical for development of AHR associated with brief allergen exposure, but is not necessary to maintain sustained AHR... - The effect of pranlukast on allergen-induced bone marrow eosinophilopoiesis in subjects with asthmaKrishnan Parameswaran
Firestone Institute for Respiratory Health, St. Joseph's Healthcare, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Am J Respir Crit Care Med 169:915-20. 2004..We conclude that, the cysteinyl leukotriene receptor antagonist, pranlukast, attenuates allergen-induced increase in airway eosinophils by decreasing bone marrow eosinophilopoiesis and airway chemotactic and eosinophilopoietic cytokines... - Retinoic acid modulates IL-5 receptor expression and selectively inhibits eosinophil-basophil differentiation of hemopoietic progenitor cellsJohn W Upham
Department of Medicine, University of Western Australia, Perth, Australia
J Allergy Clin Immunol 109:307-13. 2002..Currently, little is known concerning regulation of IL-5Ralpha expression in the context of commitment of hemopoietic progenitor cells to the eosinophil and basophil lineages... - Sputum CD34+IL-5Ralpha+ cells increase after allergen: evidence for in situ eosinophilopoiesisSandra C Dorman
Firestone Institute of Respiratory Health, Asthma Research Group, St. Joseph's Healthcare, McMaster University, Hamilton, Ontario, Canada
Am J Respir Crit Care Med 169:573-7. 2004..These results indicate that eosinophil progenitors can migrate to the airways and may differentiate toward an eosinophilic phenotype... - Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmaticsAndrew Menzies-Gow
Allergy and Clinical Immunology, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London
J Allergy Clin Immunol 111:714-9. 2003..The reduction in airway CD34(+)/IL-5 mRNA(+) cell numbers suggests that IL-5 might also be required for local tissue eosinophilopoiesis... - Allergen-induced increases in bone marrow T lymphocytes and interleukin-5 expression in subjects with asthmaLorna J Wood
Asthma Research Group, Firestone Institute for Respiratory Health, St. Joseph's Hospital and the Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Am J Respir Crit Care Med 166:883-9. 2002.... - Anti-allergic therapies: effects on eosinophil progenitorsAdrian J Baatjes
Asthma Research Group, Department of Medicine, Division of Allergy and Clinical Immunology, HSC 3V46, Canada
Pharmacol Ther 95:63-72. 2002..Therefore, targeting the systemic hematopoietic response may provide additional, more beneficial, therapeutic effects... - Kinetics of bone marrow eosinophilopoiesis and associated cytokines after allergen inhalationSandra C Dorman
Asthma Research Group, Firestone Institute for Respiratory Health, St. Joseph's Healthcare, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Am J Respir Crit Care Med 169:565-72. 2004..We propose that after allergen inhalation, time-dependent changes in cytokine levels in the bone marrow control differentiation of eosinophil/basophil progenitors... - Cysteinyl leukotrienes promote human airway smooth muscle migrationKrishnan Parameswaran
Asthma Research Group, Firestone Institute for Respiratory Health, St. Joseph's Healthcare, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Am J Respir Crit Care Med 166:738-42. 2002..The phosphatidylinositol-3 kinase pathway is a key signaling mechanism in the chemotactic migration of ASM cells in response to cysteinyl leukotrienes...