M R Sears

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. pmc A new exposure metric for traffic-related air pollution? An analysis of determinants of hopanes in settled indoor house dust
    Hind Sbihi
    School of Population and Public Health, University of British Columbia, 2206 East Mall, Vancouver, BC, Canada V6T 1Z3
    Environ Health 12:48. 2013
  2. pmc Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps
    Eric D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Respir Res 12:38. 2011
  3. pmc Associations between respiratory symptoms, lung function and gastro-oesophageal reflux symptoms in a population-based birth cohort
    Robert J Hancox
    Dunedin Multidisciplinary Health and Development Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Respir Res 7:142. 2006
  4. pmc Spatial analysis of air pollution and childhood asthma in Hamilton, Canada: comparing exposure methods in sensitive subgroups
    Talar Sahsuvaroglu
    School of Geography and Earth Sciences, 1280 King St West, Hamilton, L8S 4K1, Canada
    Environ Health 8:14. 2009
  5. ncbi request reprint Severe chronic asthma
    Malcolm R Sears
    Firestone Institute for Respiratory Health, St Joseph s Hospital McMaster University, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
    Paediatr Respir Rev 7:S123-4. 2006
  6. ncbi request reprint Is it safe to use long-acting beta-agonists in asthma and chronic obstructive pulmonary disease? Implications of recent trials and meta-analyses
    Malcolm R Sears
    Firestone Institute for Respiratory Health, St Joseph s Healthcar, McMaster University, Hamilton, ON, Canada
    Pol Arch Med Wewn 118:761-6. 2008
  7. ncbi request reprint Past, present and future--beta2-adrenoceptor agonists in asthma management
    Malcolm R Sears
    Department of Medicine, McMaster University and Firestone Institute for Respiratory Health, St Joseph s Hospital, Hamilton, Ont, L8N 4A6 Canada
    Respir Med 99:152-70. 2005
  8. ncbi request reprint A longitudinal, population-based, cohort study of childhood asthma followed to adulthood
    Malcolm R Sears
    Firestone Institute for Respiratory Health, Department of Medicine, McMaster University and St Joseph s Healthcare, Hamilton, Ont, Canada
    N Engl J Med 349:1414-22. 2003
  9. doi request reprint Epidemiology of asthma exacerbations
    Malcolm R Sears
    McMaster University and Firestone Institute for Respiratory Health, St Joseph s Healthcare Hamilton, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 122:662-8; quiz 669-70. 2008
  10. doi request reprint Safety of long-acting beta-agonists: are new data really required?
    Malcolm R Sears
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, McMaster University, Hamilton, ON, Canada
    Chest 136:604-7. 2009

Collaborators

Detail Information

Publications67

  1. pmc A new exposure metric for traffic-related air pollution? An analysis of determinants of hopanes in settled indoor house dust
    Hind Sbihi
    School of Population and Public Health, University of British Columbia, 2206 East Mall, Vancouver, BC, Canada V6T 1Z3
    Environ Health 12:48. 2013
    ..Exposure to traffic-related air pollution (TRAP) can adversely impact health but epidemiologic studies are limited in their abilities to assess long-term exposures and incorporate variability in indoor pollutant infiltration...
  2. pmc Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps
    Eric D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Respir Res 12:38. 2011
    ....
  3. pmc Associations between respiratory symptoms, lung function and gastro-oesophageal reflux symptoms in a population-based birth cohort
    Robert J Hancox
    Dunedin Multidisciplinary Health and Development Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Respir Res 7:142. 2006
    ..The role of obesity in mediating this association is also unclear. We explored the associations between respiratory symptoms, lung function, and gastro-oesophageal reflux symptoms in a birth cohort of approximately 1000 individuals...
  4. pmc Spatial analysis of air pollution and childhood asthma in Hamilton, Canada: comparing exposure methods in sensitive subgroups
    Talar Sahsuvaroglu
    School of Geography and Earth Sciences, 1280 King St West, Hamilton, L8S 4K1, Canada
    Environ Health 8:14. 2009
    ..Variations in air pollution exposure within a community may be associated with asthma prevalence. However, studies conducted to date have produced inconsistent results, possibly due to errors in measurement of the exposures...
  5. ncbi request reprint Severe chronic asthma
    Malcolm R Sears
    Firestone Institute for Respiratory Health, St Joseph s Hospital McMaster University, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
    Paediatr Respir Rev 7:S123-4. 2006
    ..Failure to respond to usual therapies requires careful consideration of differential diagnosis, type of inflammation present, compliance with therapy, and continuing monitoring and re-assessment...
  6. ncbi request reprint Is it safe to use long-acting beta-agonists in asthma and chronic obstructive pulmonary disease? Implications of recent trials and meta-analyses
    Malcolm R Sears
    Firestone Institute for Respiratory Health, St Joseph s Healthcar, McMaster University, Hamilton, ON, Canada
    Pol Arch Med Wewn 118:761-6. 2008
    ..In both asthma and chronic obstructive pulmonary disease, concomitant use of ICS should be considered best practice whenever LABAs are used...
  7. ncbi request reprint Past, present and future--beta2-adrenoceptor agonists in asthma management
    Malcolm R Sears
    Department of Medicine, McMaster University and Firestone Institute for Respiratory Health, St Joseph s Hospital, Hamilton, Ont, L8N 4A6 Canada
    Respir Med 99:152-70. 2005
    ..The recent change in classification from short- and long-acting beta2-agonists to rapid-acting and/or long-acting agents reflects the ongoing evolution of beta2-agonist therapy...
  8. ncbi request reprint A longitudinal, population-based, cohort study of childhood asthma followed to adulthood
    Malcolm R Sears
    Firestone Institute for Respiratory Health, Department of Medicine, McMaster University and St Joseph s Healthcare, Hamilton, Ont, Canada
    N Engl J Med 349:1414-22. 2003
    ..The outcome of childhood asthma in adults has been described in high-risk cohorts, but few population-based studies have reported the risk factors for persistence and relapse...
  9. doi request reprint Epidemiology of asthma exacerbations
    Malcolm R Sears
    McMaster University and Firestone Institute for Respiratory Health, St Joseph s Healthcare Hamilton, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 122:662-8; quiz 669-70. 2008
    ..Recognizing risk factors for exacerbations and implementing appropriate long-term management strategies coupled with improved compliance should reduce morbidity and mortality associated with asthma exacerbations...
  10. doi request reprint Safety of long-acting beta-agonists: are new data really required?
    Malcolm R Sears
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, McMaster University, Hamilton, ON, Canada
    Chest 136:604-7. 2009
    ..It is time to learn from the past, to rigorously avoid LABA monotherapy in asthma, and to use a LABA (when indicated) always in mandatory combination with appropriate doses of an ICS...
  11. doi request reprint Long-acting beta-agonists: a review of formoterol safety data from asthma clinical trials
    M R Sears
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, 50 Charlton Ave E, Hamilton, ON, L8N 4A6, Canada
    Eur Respir J 33:21-32. 2009
    ..Cardiac-related serious adverse events were not increased, and asthma-related serious adverse events were significantly reduced with formoterol...
  12. doi request reprint Safety of budesonide/formoterol maintenance and reliever therapy in asthma trials
    Malcolm R Sears
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and McMaster University, 50 Charlton Ave East, Hamilton, Ontario, Canada L8N 4A6
    Respir Med 103:1960-8. 2009
    ..This study examined the safety of the inhaled corticosteroid (ICS)/LABA combination budesonide/formoterol dry powder inhaler used as maintenance and reliever therapy versus combination treatments based on guideline recommendations...
  13. doi request reprint Budesonide/formoterol maintenance and reliever therapy: impact on airway inflammation in asthma
    M R Sears
    Dept of Medicine, McMaster University, Hamilton, Ontario, Canada
    Eur Respir J 31:982-9. 2008
    ....
  14. doi request reprint Safe use of long-acting ╬▓-agonists: what have we learnt?
    Malcolm R Sears
    McMaster University, Firestone Institute for Respiratory Health, St Joseph s Healthcare Hamilton, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada
    Expert Opin Drug Saf 10:767-78. 2011
    ..However, several studies have indicated an increased risk of asthma mortality and asthma-related serious adverse events and the FDA recently mandated restrictions to the use of LABAs in asthma...
  15. ncbi request reprint The evolution of beta2-agonists
    M R Sears
    McMaster University, Firestone Institute for Respiratory Health, St Joseph s Hospital, Hamilton, Ontario, Canada
    Respir Med 95:S2-6. 2001
    ..Because of its rapid onset of action, formoterol also has the potential to be used for as-needed bronchodilator therapy in asthma...
  16. ncbi request reprint Understanding the September asthma epidemic
    Malcolm R Sears
    McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 120:526-9. 2007
    ..Low use of asthma medications during summer may fuel the epidemic, which may be attenuated by the short-term addition of an effective controller therapy...
  17. doi request reprint The addition of long-acting beta-agonists to inhaled corticosteroids in asthma
    Malcolm R Sears
    McMaster University, Firestone Institute for Respiratory Health, St Joseph s Healthcare Hamilton, Hamilton, Ontario, Canada
    Curr Opin Pulm Med 17:23-8. 2011
    ..This review addresses these safety concerns together with clinical studies and meta-analyses assessing the appropriate use of LABAs...
  18. ncbi request reprint Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: a longitudinal study
    Malcolm R Sears
    Department of Medicine, McMaster University, Ontario, Hamilton, Canada
    Lancet 360:901-7. 2002
    ..Breastfeeding is widely advocated to reduce risk of atopy and asthma, but the evidence for such an effect is conflicting. We aimed to assess long-term outcomes of asthma and atopy related to breastfeeding in a New Zealand birth cohort...
  19. doi request reprint Geographical variations in the prevalence of atopic sensitization in six study sites across Canada
    M Chan-Yeung
    Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Allergy 65:1404-13. 2010
    ....
  20. ncbi request reprint Risk factors for airway remodeling in asthma manifested by a low postbronchodilator FEV1/vital capacity ratio: a longitudinal population study from childhood to adulthood
    Finn Rasmussen
    Firestone Institute for Respiratory Health, St Joseph s Hospital and McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 165:1480-8. 2002
    ..These data suggest that airway remodeling in asthma, as manifested by impaired lung function, begins in childhood and continues into adult life...
  21. pmc Sex differences in factors associated with childhood- and adolescent-onset wheeze
    Piush J Mandhane
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada
    Am J Respir Crit Care Med 172:45-54. 2005
    ..Factors predicting the development of wheeze may differ between sexes and between childhood and adolescence...
  22. pmc Canadian economic evaluation of budesonide-formoterol as maintenance and reliever treatment in patients with moderate to severe asthma
    Elizabeth Miller
    Axia Research Inc, 181 Main Street West, Hamilton, Ontario, Canada
    Can Respir J 14:269-75. 2007
    ....
  23. ncbi request reprint The September epidemic of asthma exacerbations in children: a search for etiology
    Neil W Johnston
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 115:132-8. 2005
    ..Predictable peaks of asthma exacerbation requiring hospital treatment, of greatest magnitude in children and of uncertain etiology, occur globally after school returns...
  24. ncbi request reprint Differential cell counts in sputum in respiratory epidemiology: a pilot study
    C Lemiere
    Asthma Research Group, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Chest 120:1107-13. 2001
    ..The aim of this pilot study was to determine whether measuring sputum differential cell counts, particularly eosinophils, could be a useful method of validating self-reported symptoms suggesting asthma in epidemiologic studies...
  25. pmc Asthma exacerbations . 1: epidemiology
    N W Johnston
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
    Thorax 61:722-8. 2006
    ..Epidemiologically, the degree of asthma control achieved by asthmatics is an important predictor of the likelihood of disease exacerbation including respiratory failure, death, and health service consumption...
  26. doi request reprint Measuring asthma control: a comparison of three classification systems
    P M O'Byrne
    Michael G DeGroote School of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    Eur Respir J 36:269-76. 2010
    ..GINA Controlled/Partly Controlled and GOAL Totally Controlled/Well-Controlled correspond to ACQ-5 <1.00. The ACQ-5 is more responsive to change in a clinical trial setting than a categorical scale...
  27. ncbi request reprint Asthma treatment: inhaled beta-agonists
    M R Sears
    St Joseph s Hospital and McMaster University, Hamilton, Canada
    Can Respir J 5:54A-9A. 1998
    ..Long acting beta-agonists are indicated in individuals whose asthma is not well controlled on moderate doses of inhaled corticosteroid, and are complementary to, not a replacement for, inhaled corticosteroid therapy...
  28. ncbi request reprint Attenuation of the September epidemic of asthma exacerbations in children: a randomized, controlled trial of montelukast added to usual therapy
    Neil W Johnston
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, 50 Charlton Ave E, Hamilton, Ontario, Canada L8N 4A6
    Pediatrics 120:e702-12. 2007
    ..A recurring epidemic of asthma exacerbations in children occurs annually in September in North America when school resumes after summer vacation...
  29. ncbi request reprint Interactions between breast-feeding, specific parental atopy, and sex on development of asthma and atopy
    Piush J Mandhane
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 119:1359-66. 2007
    ..The influence of breast-feeding on the risk of developing atopy and asthma remains controversial...
  30. doi request reprint The safety of long-acting beta-agonists among patients with asthma using inhaled corticosteroids: systematic review and metaanalysis
    Roman Jaeschke
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 178:1009-16. 2008
    ..Objectives: To determine the safety of long-acting beta-agonists among patients with asthma using corticosteroids...
  31. ncbi request reprint The September epidemic of asthma hospitalization: school children as disease vectors
    Neil W Johnston
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 117:557-62. 2006
    ..Viral infections are associated with the majority of asthma exacerbations in children and adults. Increased asthma hospitalization rates of children and adults, particularly in the early fall, have been observed to follow school vacations...
  32. ncbi request reprint Inhaled corticosteroids for asthma: common clinical quandaries
    Krishnan Parameswaran
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Asthma 40:107-18. 2003
    ..However, they do not normalize lung function and prevent structural changes in the airway wall in all asthmatic patients...
  33. ncbi request reprint The safety of formoterol among patients with asthma using inhaled corticosteroids. Systematic review and meta-analysis
    Roman Jaeschke
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Pol Arch Med Wewn 118:627-35. 2008
    ....
  34. ncbi request reprint Occupational asthma in adults in six Canadian communities
    A R Johnson
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 162:2058-62. 2000
    ..The PAR for adult-onset asthma in high-risk jobs and exposures was 18.2%. The assessment of occupation and industry alone, rather than of exposures, may underestimate the contribution of occupational exposures to asthma prevalence...
  35. doi request reprint Variations and gaps in management of acute asthma in Ontario emergency departments
    M Diane Lougheed
    Division of Respirology, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Chest 135:724-36. 2009
    ..We investigated ED management of asthma and differences in practice patterns for pediatric (< 20 years old) and adult (> or = 20 years old) patients in Ontario EDs...
  36. doi request reprint Breastfeeding and allergies: time for a change in paradigm?
    Joanne M Duncan
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and McMaster University, Hamilton, Ontario, Canada
    Curr Opin Allergy Clin Immunol 8:398-405. 2008
    ..This review examines recent studies of the relationships between breastfeeding and the epidemiology of allergic diseases, especially atopic dermatitis in infants and asthma in early and later childhood...
  37. ncbi request reprint Risk factors for hospital admission for asthma from childhood to young adulthood: a longitudinal population study
    Finn Rasmussen
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, and McMaster University, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada
    J Allergy Clin Immunol 110:220-7. 2002
    ..Predictors of hospital admissions for asthma in children and young adults in a general population are not well defined, because most studies have used selected subpopulations...
  38. pmc Relation between income, air pollution and mortality: a cohort study
    Murray M Finkelstein
    Program in Occupational Health and Environmental Medicine, the Institute of Environment and Health, and Department of Family Medicine, McMaster University, Hamilton, ON
    CMAJ 169:397-402. 2003
    ..We investigated mortality in relation to neighbourhood levels of income and air pollution in an urban area...
  39. ncbi request reprint Outcome in adulthood of asymptomatic airway hyperresponsiveness in childhood: a longitudinal population study
    Finn Rasmussen
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and McMaster University, Hamilton, Ontario, Canada
    Pediatr Pulmonol 34:164-71. 2002
    ..We suggest that rather than considering AHR as a marker of asthma, it should be regarded as a parallel pathological process that may lead to subsequent symptoms and clinical evidence of asthma...
  40. ncbi request reprint Adverse effects of beta-agonists
    Malcolm R Sears
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Master University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 110:S322-8. 2002
    ..Postmarketing surveillance studies have not suggested significant adverse effects of long-acting beta-agonists on morbidity and mortality...
  41. pmc Environmental inequality and circulatory disease mortality gradients
    Murray M Finkelstein
    Program in Occupational Health and Environmental Medicine and Institute of Environment and Health, McMaster University, Toronto, Canada
    J Epidemiol Community Health 59:481-7. 2005
    ..The aim of this study was to test the hypotheses that exposure to traffic and air pollution might account for some of the socioeconomic differences in mortality rates in a city where residents are covered by universal health insurance...
  42. ncbi request reprint Nicotine replacement combined with a novel compound (ProBAN) for smoking cessation: a pilot study
    R Leigh
    Firestone Regional Chest and Allergy Unit, St Joseph's Hospital, Hamilton, Canada
    Can Respir J 8:21-6. 2001
    ..Although not statistically significant due to the size of the study, this result suggests that it may be an effective therapy for smoking cessation, and larger studies are warranted...
  43. ncbi request reprint Consequences of long-term inflammation. The natural history of asthma
    M R Sears
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin Chest Med 21:315-29. 2000
    ..The overall effect of treatment on the natural history of the disease is not yet clear, despite significant short-term improvements from effective anti-inflammatory therapy...
  44. ncbi request reprint Traffic air pollution and mortality rate advancement periods
    Murray M Finkelstein
    Program in Occupational Health and Environmental Medicine, and Institute of Environment and Health, McMaster University, Hamilton, Ontario, Canada
    Am J Epidemiol 160:173-7. 2004
    ..5 years (95% confidence interval: 0.2, 4.8). By comparison, the rate advancement periods attributable to chronic pulmonary disease, chronic ischemic heart disease, and diabetes were 3.4 years, 3.1 years, and 4.4 years, respectively...
  45. ncbi request reprint The chicken or the egg? Perhaps the egg
    Padmaja Subbarao
    Sick Children s Hospital, University of Toronto, Toronto, Ontario, Canada
    Arch Dis Child 93:552-3. 2008
  46. ncbi request reprint Multicentre evaluation of an emergency department asthma care pathway for adults
    M Diane Lougheed
    Clinical Research Centre, Kingston General Hospital, Kingston, Ontario, Canada
    CJEM 11:215-29. 2009
    ..We sought to determine whether a standardized emergency department (ED) asthma care pathway (ACP) for adults would be accepted by ED staff, improve adherence to Canadian ED asthma management guidelines and improve patient outcomes...
  47. doi request reprint Disparate geographic prevalences of asthma, allergic rhinoconjunctivitis and atopic eczema among adolescents in five Canadian cities
    Hong Yu Wang
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, Hamilton, ON, Canada
    Pediatr Allergy Immunol 21:867-77. 2010
    ..This disparity in regional variations in the prevalence rates suggests dissimilar risk factors for the development or expression of wheezing (asthma), allergic rhinoconjunctivitis and atopic eczema...
  48. ncbi request reprint Geographic and gender variability in the prevalence of bronchial responsiveness in Canada
    Jure Manfreda
    Department of Medicine, University of Manitoba, Winnipeg, MB, Canada
    Chest 125:1657-64. 2004
    ..We measured bronchial responsiveness using the standardized protocol of the European Community Respiratory Health Survey (ECRHS) in six sites in Canada, and compared prevalences across Canada with international sites...
  49. ncbi request reprint The Ontario Asthma Regional Variation Study: emergency department visit rates and the relation to hospitalization rates
    M Diane Lougheed
    Division of Respirology, Department of Medicine, Queen s University, Kingston, ON, Canada
    Chest 129:909-17. 2006
    ..Hospitalization rates for asthma vary more than threefold across regions of Ontario. It is not known whether this variation is primarily due to regional differences in the rate of emergency department (ED) visits or hospital admissions...
  50. doi request reprint Changes in exhaled nitric oxide related to estrogen and progesterone during the menstrual cycle
    Piush J Mandhane
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, Hamilton, ON, Canada
    Chest 136:1301-7. 2009
    ....
  51. ncbi request reprint Adjustable maintenance dosing with budesonide/formoterol reduces asthma exacerbations compared with traditional fixed dosing: a five-month multicentre Canadian study
    J Mark FitzGerald
    The University of British Columbia, Vancouver, Canada
    Can Respir J 10:427-34. 2003
    ..Adjustable maintenance dosing with budesonide/formoterol in a single inhaler (Symbicort, AstraZeneca, Lund, Sweden) may provide a convenient means of maintaining asthma control with the minimum effective medication level...
  52. ncbi request reprint A longitudinal study of the effects of tobacco and cannabis exposure on lung function in young adults
    D Robin Taylor
    Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Addiction 97:1055-61. 2002
    ..To assess the possible effects of tobacco and cannabis smoking on lung function in young adults between the ages of 18 and 26...
  53. ncbi request reprint Prediction of differential adult health burden by conduct problem subtypes in males
    Candice L Odgers
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, England
    Arch Gen Psychiatry 64:476-84. 2007
    ..Whether such developmental subtypes exist in the population and have different prognoses should be rigorously tested to inform the DSM-V...
  54. ncbi request reprint Sex differences in the relation between body mass index and asthma and atopy in a birth cohort
    Robert J Hancox
    Dunedin Multidisciplinary Health and Development Research Unit, Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, PO Box 913, Dunedin, New Zealand
    Am J Respir Crit Care Med 171:440-5. 2005
    ..It remains unclear if this association is due to genuine asthma or to symptoms caused by overweight, at what age the association develops, and whether it is confined to females...
  55. ncbi request reprint Asthma in remission: can relapse in early adulthood be predicted at 18 years of age?
    D Robin Taylor
    Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, PO Box 913, Dunedin, New Zealand
    Chest 127:845-50. 2005
    ..To determine the frequency of relapse of asthma in young adults in remission at 18 years of age, during a follow-up period of 8 years, and to identify possible prognostic markers for relapse...
  56. pmc Airflow obstruction in young adults in Canada
    Manal Al-Hazmi
    University of Manitoba, Winnipeg, Manitoba
    Can Respir J 14:221-7. 2007
    ..The objective of the present study was to enumerate and characterize airflow obstruction in a random sample of Canadians aged 20 to 44 years...
  57. doi request reprint Female and male antisocial trajectories: from childhood origins to adult outcomes
    Candice L Odgers
    Department of Psychology and Social Behavior, University of California Irvine, Irvine, CA92697 7085, USA
    Dev Psychopathol 20:673-716. 2008
    ..Implications for theory, research, and practice are discussed...
  58. ncbi request reprint Association between exhaled nitric oxide and systemic inflammatory markers
    Tim J T Sutherland
    Dunedin Multidisciplinary Health and Development Unit, Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Ann Allergy Asthma Immunol 99:534-9. 2007
    ..Exhaled nitric oxide is a noninvasive measure of asthmatic airway inflammation...
  59. ncbi request reprint Association between exhaled nitric oxide and systemic inflammatory markers
    Tim J T Sutherland
    Dunedin Multidisciplinary Health and Development Unit, Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Ann Allergy Asthma Immunol 99:334-9. 2007
    ..Exhaled nitric oxide is a noninvasive measure of asthmatic airway inflammation...
  60. ncbi request reprint Cigarette smoking and allergic sensitization: a 32-year population-based cohort study
    Robert J Hancox
    Dunedin Multidisciplinary Health and Development Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    J Allergy Clin Immunol 121:38-42.e3. 2008
    ..Cigarette smoke has immunosuppressant effects, but its effect on allergic sensitization is unclear...
  61. ncbi request reprint Asthma mortality in southern Brazil: is there a changing trend?
    Gustavo Chatkin
    School of Medicine, Pontificia Universidade Catolica do Rio Grande do Sul PUCRS, Porto Alegre RS 90610 000
    J Asthma 44:133-6. 2007
    ..Mortality from asthma increased during the last decades but is now declining in some countries. Little is known about this trend in Brazil...
  62. pmc Factors affecting exhaled nitric oxide measurements: the effect of sex
    D Robin Taylor
    Department of Respiratory Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Respir Res 8:82. 2007
    ..However, many constitutional and environmental factors affect F(E)NO, making it difficult to devise reference values. Our aim was to evaluate the relative importance of factors affecting F(E)NO in a well characterised adult population...
  63. pmc Association between children's experience of socioeconomic disadvantage and adult health: a life-course study
    Richie Poulton
    Dunedin Multidisciplinary Health and Development Research Unit, Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, PO Box 913, Dunedin, New Zealand
    Lancet 360:1640-5. 2002
    ..We aimed to test the hypothesis that children's experience of socioeconomic disadvantage is associated with a wide range of health risk factors and outcomes in adult life...
  64. ncbi request reprint Adiposity, asthma, and airway inflammation
    Christene R McLachlan
    Dunedin Multidisciplinary Health and Development Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    J Allergy Clin Immunol 119:634-9. 2007
    ..One possible explanation might be that these studies have used body mass index to identify adiposity, which might be a less reliable measure of body fat in men than in women...
  65. doi request reprint Long-acting bronchodilators in COPD
    Malcolm R Sears
    Chest 133:1057-8. 2008
  66. ncbi request reprint The Salmeterol Multicenter Asthma Research Trial
    Malcolm R Sears
    Chest 130:928; author reply 928-9. 2006
  67. pmc Systemic inflammation and lung function in young adults
    Robert J Hancox
    Dunedin Multidisciplinary Health and Development Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Thorax 62:1064-8. 2007
    ..We explored the association between the forced expiratory volume in one second (FEV(1)) and the systemic inflammatory marker C-reactive protein (CRP) in young adults...