Holger Schunemann

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint [Integrative assessment of evidence in healthcare: the GRADE system]
    Holger Schunemann
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Z Evid Fortbild Qual Gesundhwes 103:261-8. 2009
  2. doi request reprint Methodological survey of designed uneven randomization trials (DU-RANDOM): a protocol
    Darong Wu
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    Trials 15:33. 2014
  3. pmc Developing and Evaluating Communication Strategies to Support Informed Decisions and Practice Based on Evidence (DECIDE): protocol and preliminary results
    Shaun Treweek
    Population Health Sciences, University of Dundee, Kirsty Semple Way, Dundee, UK
    Implement Sci 8:6. 2013
  4. pmc Strategies to enhance venous thromboprophylaxis in hospitalized medical patients (SENTRY): a pilot cluster randomized trial
    Menaka Pai
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Implement Sci 8:1. 2013
  5. pmc Developing clinical practice guidelines: target audiences, identifying topics for guidelines, guideline group composition and functioning and conflicts of interest
    Martin P Eccles
    Institute of Health and Society, Newcastle University, Baddiley Clark building, Richardson Road, Newcastle upon Tyne NE2 4AX, UK
    Implement Sci 7:60. 2012
  6. pmc Developing clinical practice guidelines: reviewing, reporting, and publishing guidelines; updating guidelines; and the emerging issues of enhancing guideline implementability and accounting for comorbid conditions in guideline development
    Paul Shekelle
    RAND Corporation, Santa Monica, CA 90407, USA
    Implement Sci 7:62. 2012
  7. pmc Developing clinical practice guidelines: types of evidence and outcomes; values and economics, synthesis, grading, and presentation and deriving recommendations
    Steven Woolf
    Department of Family Medicine and Center on Human Needs, Virginia Commonwealth University, Richmond, VA, USA
    Implement Sci 7:61. 2012
  8. pmc Patient-reported outcomes in meta-analyses--Part 1: assessing risk of bias and combining outcomes
    Bradley C Johnston
    Department of Anesthesia and Pain Medicine, and Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada
    Health Qual Life Outcomes 11:109. 2013
  9. pmc Using GRADE methodology for the development of public health guidelines for the prevention and treatment of HIV and other STIs among men who have sex with men and transgender people
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, NY, USA
    BMC Public Health 12:386. 2012
  10. pmc Academic detailing and adherence to guidelines for Group B streptococci prenatal screening: a randomized controlled trial
    Jussara M Silva
    Department of Epidemiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    BMC Pregnancy Childbirth 13:68. 2013

Detail Information

Publications79

  1. ncbi request reprint [Integrative assessment of evidence in healthcare: the GRADE system]
    Holger Schunemann
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Z Evid Fortbild Qual Gesundhwes 103:261-8. 2009
    ..The international collaboration and acceptance by many organisations is an indicator of GRADE's innovative nature and advances in the assessment of evidence and development of recommendations in the context of healthcare...
  2. doi request reprint Methodological survey of designed uneven randomization trials (DU-RANDOM): a protocol
    Darong Wu
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    Trials 15:33. 2014
    ..Until now, no convincing data exists addressing the impact of DUR on participation rates in trials. The objective of this study is to evaluate the epidemiology and to explore factors associated with DUR...
  3. pmc Developing and Evaluating Communication Strategies to Support Informed Decisions and Practice Based on Evidence (DECIDE): protocol and preliminary results
    Shaun Treweek
    Population Health Sciences, University of Dundee, Kirsty Semple Way, Dundee, UK
    Implement Sci 8:6. 2013
    ..Healthcare decision makers face challenges when using guidelines, including understanding the quality of the evidence or the values and preferences upon which recommendations are made, which are often not clear...
  4. pmc Strategies to enhance venous thromboprophylaxis in hospitalized medical patients (SENTRY): a pilot cluster randomized trial
    Menaka Pai
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Implement Sci 8:1. 2013
    ..Knowledge-translation strategies are needed to bridge this gap...
  5. pmc Developing clinical practice guidelines: target audiences, identifying topics for guidelines, guideline group composition and functioning and conflicts of interest
    Martin P Eccles
    Institute of Health and Society, Newcastle University, Baddiley Clark building, Richardson Road, Newcastle upon Tyne NE2 4AX, UK
    Implement Sci 7:60. 2012
    ....
  6. pmc Developing clinical practice guidelines: reviewing, reporting, and publishing guidelines; updating guidelines; and the emerging issues of enhancing guideline implementability and accounting for comorbid conditions in guideline development
    Paul Shekelle
    RAND Corporation, Santa Monica, CA 90407, USA
    Implement Sci 7:62. 2012
    ....
  7. pmc Developing clinical practice guidelines: types of evidence and outcomes; values and economics, synthesis, grading, and presentation and deriving recommendations
    Steven Woolf
    Department of Family Medicine and Center on Human Needs, Virginia Commonwealth University, Richmond, VA, USA
    Implement Sci 7:61. 2012
    ....
  8. pmc Patient-reported outcomes in meta-analyses--Part 1: assessing risk of bias and combining outcomes
    Bradley C Johnston
    Department of Anesthesia and Pain Medicine, and Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada
    Health Qual Life Outcomes 11:109. 2013
    ....
  9. pmc Using GRADE methodology for the development of public health guidelines for the prevention and treatment of HIV and other STIs among men who have sex with men and transgender people
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, NY, USA
    BMC Public Health 12:386. 2012
    ..The objective of this paper is to review the methodological challenges faced and solutions applied during the development of the guidelines...
  10. pmc Academic detailing and adherence to guidelines for Group B streptococci prenatal screening: a randomized controlled trial
    Jussara M Silva
    Department of Epidemiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    BMC Pregnancy Childbirth 13:68. 2013
    ..This study examined the effectiveness of academic detailing (AD) of obstetricians, compared with CPG mailshot and no intervention, on the screening of pregnant women for GBS...
  11. pmc Systematic evaluation of the methodology of randomized controlled trials of anticoagulation in patients with cancer
    Gabriel Rada
    Evidence Based Health Care Program, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    BMC Cancer 13:76. 2013
    ..In view of recent interest in the treatment and prevention of thrombotic complications in cancer patients we evaluated the characteristics, risk of bias and their time trends in RCTs of anticoagulation in patients with cancer...
  12. doi request reprint Methodological idiosyncracies, frameworks and challenges of non-pharmaceutical and non-technical treatment interventions
    Holger J Schunemann
    Departments of Clinical Epidemiology and Biostatistics and of Medicine, McMaster University Health Sciences Centre, Hamilton, Canada
    Z Evid Fortbild Qual Gesundhwes 107:214-20. 2013
    ..As supplied by publisher). ..
  13. pmc Editorial: can China master the guideline challenge?
    Kehu Yang
    Departments of Clinical Epidemiology and Biostatistics and of Medicine, McMaster University Health Sciences Centre, Room 2C16, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada
    Health Res Policy Syst 11:1. 2013
    ..China can build on what is known and work with the international community to develop methods to meet the challenges of evidence-based guideline development...
  14. doi request reprint [Diagnostic accuracy and linked evidence--testing the chain]
    Holger J Schunemann
    Department of Clinical Epidemiology and Biostatistics, WHO Collaborating Center for Evidence informed Policy, Cochrane Applicability and Recommendations Methods Group, McMaster University Health Sciences Centre, Hamilton, ON, Canada
    Z Evid Fortbild Qual Gesundhwes 106:153-60. 2012
    ....
  15. pmc The GRADE approach for assessing new technologies as applied to apheresis devices in ulcerative colitis
    Nora Ibargoyen-Roteta
    Basque Office for Health Technology Assessment OSTEBA, Department of Health and Consumer Affairs of the Basque Country, Vitoria Gasteiz, Spain
    Implement Sci 5:48. 2010
    ..The aim of the present study is to describe the use of this approach in the development of recommendations for a new health technology, and to analyse the strengths, weaknesses, opportunities, and threats found when doing so...
  16. pmc Improving the interpretation of quality of life evidence in meta-analyses: the application of minimal important difference units
    Bradley C Johnston
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Health Qual Life Outcomes 8:116. 2010
    ..This approach provides a potential solution to both the statistical and interpretational problems of existing methods...
  17. pmc How a well-grounded minimal important difference can enhance transparency of labelling claims and improve interpretation of a patient reported outcome measure
    Jan L Brozek
    Department of Medicine, Jagiellonian University School of Medicine, Krakow, Poland
    Health Qual Life Outcomes 4:69. 2006
    ....
  18. pmc Systems medicine and integrated care to combat chronic noncommunicable diseases
    Jean Bousquet
    Department of Respiratory Diseases, Arnaud de Villeneuve Hospital, CHU Montpellier, INSERM CESP U1018, Villejuif, France
    Genome Med 3:43. 2011
    ..This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems...
  19. pmc Association between anemia and quality of life in a population sample of individuals with chronic obstructive pulmonary disease
    Gokul Krishnan
    Department of Medicine, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, USA
    BMC Pulm Med 6:23. 2006
    ..However, there is little evidence regarding the association of anemia with HRQL in patients with chronic obstructive pulmonary disease (COPD)...
  20. pmc Support for and aspects of use of educational games in family medicine and internal medicine residency programs in the US: a survey
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, Buffalo, NY, USA
    BMC Med Educ 10:26. 2010
    ..The objective of this study was to explore the support for and the different aspects of use of educational games in family medicine and internal medicine residency programs in the United States...
  21. pmc Values and preferences in oral anticoagulation in patients with atrial fibrillation, physicians' and patients' perspectives: protocol for a two-phase study
    Pablo Alonso-Coello
    Iberoamerican Cochrane Center, Hospital Sant Pau, Sant Antoni Maria Claret 171, Barcelona, Spain
    BMC Health Serv Res 8:221. 2008
    ..The literature postulates that patient and clinician preferences may explain this low utilization...
  22. pmc Educational games in geriatric medicine education: a systematic review
    Ziad Alfarah
    Geriatrics Section, Department of Medicine, Boston University, Boston, MA, USA
    BMC Geriatr 10:19. 2010
    ..To systematically review the medical literature to assess the effect of geriatric educational games on the satisfaction, knowledge, beliefs, attitudes and behaviors of health care professionals...
  23. pmc The impact of illness in patients with moderate to severe gastro-esophageal reflux disease
    Samer El-Dika
    Division of Gastroenterology, Veterans Affairs Medical Center, Salem, Virginia, USA
    BMC Gastroenterol 5:23. 2005
    ..Gastro-esophageal reflux disease (GERD) is a common disease. It impairs health related quality of life (HRQL). However, the impact on utility scores and work productivity in patients with moderate to severe GERD is not well known...
  24. ncbi request reprint [GRADE: from grading the evidence to developing recommendations. A description of the system and a proposal regarding the transferability of the results of clinical research to clinical practice]
    Holger J Schunemann
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Z Evid Fortbild Qual Gesundhwes 103:391-400. 2009
    ..In addition to providing an overview of the GRADE system, this article focuses on the approach to assessing directness or generalizability...
  25. pmc An instrument to assess quality of life in relation to nutrition: item generation, item reduction and initial validation
    Holger J Schunemann
    Department of Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA
    Health Qual Life Outcomes 8:26. 2010
    ..Therefore, the aim of this project was to develop an instrument for measuring QoL related to nutrition in the general population...
  26. pmc Application of GRADE: making evidence-based recommendations about diagnostic tests in clinical practice guidelines
    Jonathan Hsu
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Implement Sci 6:62. 2011
    ..Therefore, we evaluated the factors that guideline developers and users need to consider for the development of implementable recommendations about diagnostic tests...
  27. doi request reprint Guidelines 2.0: do no net harm-the future of practice guideline development in asthma and other diseases
    Holger J Schunemann
    Department of Clinical Epidemiology and Biostatistics, McMaster University Health Sciences Centre, Hamilton, ON, Canada
    Curr Allergy Asthma Rep 11:261-8. 2011
    ....
  28. doi request reprint The GRADE approach and Bradford Hill's criteria for causation
    Holger Schunemann
    Department of Clinical Epidemiology and Biostatistics, McMaster University Health Sciences Centre, 1200 Main Street West, Hamilton, Ontario, Canada
    J Epidemiol Community Health 65:392-5. 2011
    ..This article describes how causation may relate to developing recommendations and how the Bradford Hill criteria are considered in GRADE, using examples from the public health literature with a focus on immunisation...
  29. pmc Grading quality of evidence and strength of recommendations for diagnostic tests and strategies
    Holger J Schunemann
    Department of Epidemiology, Italian National Cancer Institute Regina Elena, 00144 Rome, Italy
    BMJ 336:1106-10. 2008
  30. ncbi request reprint WHO Rapid Advice Guidelines for pharmacological management of sporadic human infection with avian influenza A (H5N1) virus
    Holger J Schunemann
    Italian National Cancer Institute Regina Elena, INFORMA Unit, Department of Epidemiology, Istituto Regina Elena, Rome, Italy
    Lancet Infect Dis 7:21-31. 2007
    ..Emergence of other novel influenza A viral subtypes with pandemic potential, or changes in the pathogenicity of H5N1 virus strains, will require an update of these guidelines and WHO will be monitoring this closely...
  31. ncbi request reprint A randomised trial to evaluate the self-administered standardised chronic respiratory questionnaire
    H J Sch√ľnemann
    Department of Medicine, University Health Sciences Centre, Room 2C12, Hamilton, Ontario L8N 3Z5, Canada
    Eur Respir J 25:31-40. 2005
    ..These results challenge the assumption that interviewer-administered questionnaires are superior to self-administered questionnaires in older patients with chronic respiratory disease...
  32. ncbi request reprint Do clinical marker states improve responsiveness and construct validity of the standard gamble and feeling thermometer: a randomized multi-center trial in patients with chronic respiratory disease
    Holger J Schunemann
    Division of Clinical Research Development and INFORMAtion Translation INFROMA, Italian National Cancer Institute Regina Elena, Rome, Italy
    Qual Life Res 15:1-14. 2006
    ..We evaluated the impact of clinical marker state (CMS) rating prior to patients' rating their own health on two utility instruments (feeling thermometer (FT) and standard gamble (SG)) in patients with chronic respiratory disease (CRD)...
  33. ncbi request reprint A comparison of narrative and table formats for presenting hypothetical health states to patients with gastrointestinal or pulmonary disease
    Holger J Schunemann
    McMaster University Health Sciences Centre, Room 2C12, Hamilton, Ontario, L8N 3Z5, Canada
    Med Decis Making 24:53-60. 2004
    ..Investigators should consider using the table presentation for describing health states to subjects who are not familiar with these states of health...
  34. pmc Interpreting the results of patient reported outcome measures in clinical trials: the clinician's perspective
    Holger J Schunemann
    Division of Clinical Research Development and INFORMAtion Translation, Department of Epidemiology, Istituto Regina Elena Italian National Cancer Institute Rome, Rome, Italy
    Health Qual Life Outcomes 4:62. 2006
    ..Thus, there are several steps investigators can take to facilitate this process to help bringing HRQL information closer to the bedside...
  35. ncbi request reprint Measurement properties and interpretability of the Chronic respiratory disease questionnaire (CRQ)
    Holger J Schunemann
    Departments of Medicine, School of Medicine and Biomedical Sciences, University at Buffalo, State of New York, Buffalo, New York, USA
    COPD 2:81-9. 2005
    ..These objectives include the exploration of presentation of quality of life information and prospective anchor-based approaches...
  36. pmc Transparent development of the WHO rapid advice guidelines
    Holger J Schunemann
    Italian National Cancer Institute Regina Elena, Department of Epidemiology, Rome, Italy
    PLoS Med 4:e119. 2007
    ..The process could be improved by shortening the time required to commission evidence profiles. Further development is needed to facilitate stakeholder involvement, and evaluate and ensure the guideline's usefulness...
  37. ncbi request reprint Evaluation of the minimal important difference for the feeling thermometer and the St. George's Respiratory Questionnaire in patients with chronic airflow obstruction
    Holger J Schunemann
    Department of Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 462 Grider Street, Buffalo, NY 14215, USA
    J Clin Epidemiol 56:1170-6. 2003
    ..The objective of our study is to explore the interpretation of the SGRQ and FT...
  38. ncbi request reprint Application of generalizability theory confirmed lower reliability of the standard gamble than the feeling thermometer
    Holger J Schunemann
    Department of Epidemiology, INFORMA Unit CLARITY Research Group, Italian National Cancer Institute Regina Elena, Via Elio Chianesi 53, 00144 Rome, Italy
    J Clin Epidemiol 60:1256-62. 2007
    ..Further, lack of interrater reliability may compromise the use of CMS in interpreting health state ratings. The aim of this study was to assess the reliability of CMS ratings for the SG and the FT...
  39. ncbi request reprint A randomized multicenter trial to evaluate simple utility elicitation techniques in patients with gastroesophageal reflux disease
    Holger J Schunemann
    Department of Medicine, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA
    Med Care 42:1132-42. 2004
    ..We evaluated whether the administration of marker states improves measurement properties of the FT and SG...
  40. doi request reprint The diagnosis of myocardial infarction in critically ill patients: an agreement study
    Wendy Lim
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 24:447-52. 2009
    ..The aim of the study was to assess agreement among 4 intensivists in diagnosing myocardial infarction (MI) in critically ill patients based on screening electrocardiograms (ECGs) and cardiac troponin (cTn) levels...
  41. ncbi request reprint Parenteral anticoagulation in patients with cancer who have no therapeutic or prophylactic indication for anticoagulation
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, ECMC CC 142, 462 Grider Street, Buffalo, NY, USA, 14215
    Cochrane Database Syst Rev 4:CD006652. 2011
    ..Anticoagulation may improve survival in patients with cancer through an antitumor effect in addition to the perceived antithrombotic effect...
  42. ncbi request reprint [Patient reported outcomes: general principles of development and interpretability]
    Dianne Bryant
    Faculty of Health Sciences, Elborn College, Room 1438, University of Western Ontario, London, ON, Canada
    Pol Arch Med Wewn 117:5-11. 2007
    ....
  43. ncbi request reprint Framing of health information messages
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, ECMC CC 142, 462 Grider Street, Buffalo, NY, USA, 14215
    Cochrane Database Syst Rev 12:CD006777. 2011
    ....
  44. doi request reprint The vexing problem of guidelines and conflict of interest: a potential solution
    Gordon Guyatt
    McMaster University Health Sciences Centre, Henderson General Hospital, Hamilton, Ontario, Canada
    Ann Intern Med 152:738-41. 2010
    ..These strategies may help to achieve the benefits of expert input without conflicts of interest influencing recommendations...
  45. ncbi request reprint Anticoagulation for the initial treatment of venous thromboembolism in patients with cancer
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, ECMC CC 142, 462 Grider Street, Buffalo, NY, USA, 14215
    Cochrane Database Syst Rev 6:CD006649. 2011
    ..Compared to patients without cancer, patients with cancer who receive anticoagulant treatment for venous thromboembolism are more likely to develop recurrent venous thromboembolism (VTE)...
  46. ncbi request reprint Oral anticoagulation in patients with cancer who have no therapeutic or prophylactic indication for anticoagulation
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, ECMC CC 142, 462 Grider Street, Buffalo, NY, USA, 14215
    Cochrane Database Syst Rev 6:CD006466. 2011
    ..A number of basic research and clinical studies have led to the hypothesis that oral anticoagulants may improve the survival of patients with cancer through an antitumor effect in addition to their antithrombotic effect...
  47. ncbi request reprint Low molecular weight heparin versus unfractionated heparin for perioperative thromboprophylaxis in patients with cancer
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, ECMC CC 142, 462 Grider Street, Buffalo, NY, USA, 14215
    Cochrane Database Syst Rev 11:CD009447. 2011
    ..The choice of the appropriate perioperative thromboprophylaxis in patients with cancer depends on the relative benefits and harms of low molecular weight heparin (LMWH) and unfractionated heparin (UFH)...
  48. doi request reprint Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis
    Dirk Bassler
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    JAMA 303:1180-7. 2010
    ..Theory and simulation suggest that randomized controlled trials (RCTs) stopped early for benefit (truncated RCTs) systematically overestimate treatment effects for the outcome that precipitated early stopping...
  49. ncbi request reprint Anticoagulation for the initial treatment of venous thromboembolism in patients with cancer
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, ECMC CC 142, 462 Grider Street, Buffalo, NY, USA, 14215
    Cochrane Database Syst Rev 4:CD006649. 2011
    ..Compared to patients without cancer, patients with cancer who receive anticoagulant treatment for venous thromboembolism are more likely to develop recurrent venous thromboembolism (VTE)...
  50. ncbi request reprint Anticoagulation for patients with cancer and central venous catheters
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, ECMC CC 142, 462 Grider Street, Buffalo, NY, USA, 14215
    Cochrane Database Syst Rev 2:CD006468. 2011
    ..Central venous catheter (CVC) placement increases the risk of thrombosis in cancer patients. Thrombosis often necessitates the removal of the CVC, resulting in treatment delays and thrombosis related morbidity and mortality...
  51. ncbi request reprint Anticoagulation for the initial treatment of venous thromboembolism in patients with cancer
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, ECMC CC 142, 462 Grider Street, Buffalo, NY, USA, 14215
    Cochrane Database Syst Rev 2:CD006649. 2011
    ..Compared to patients without cancer, patients with cancer who receive anticoagulant treatment for venous thromboembolism are more likely to develop recurrent venous thromboembolism (VTE)...
  52. ncbi request reprint Anticoagulation for patients with cancer and central venous catheters
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, ECMC CC 142, 462 Grider Street, Buffalo, NY, USA, 14215
    Cochrane Database Syst Rev 4:CD006468. 2011
    ..Central venous catheter (CVC) placement increases the risk of thrombosis in cancer patients. Thrombosis often necessitates the removal of the CVC, resulting in treatment delays and thrombosis related morbidity and mortality...
  53. doi request reprint Use of GRADE grid to reach decisions on clinical practice guidelines when consensus is elusive
    Roman Jaeschke
    Department of Medicine, McMaster University, Hamilton, ON, Canada L8P 3B6
    BMJ 337:a744. 2008
  54. pmc Orthopaedic surgeons prefer to participate in expertise-based randomized trials
    Elzbieta Bednarska
    Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    Clin Orthop Relat Res 466:1734-44. 2008
    ..The expertise-based randomized clinical trial design may overcome some of the barriers to conducting clinical trials in orthopaedic surgery and improve the validity of their conclusions...
  55. pmc An international prospective cohort study evaluating major vascular complications among patients undergoing noncardiac surgery: the VISION Pilot Study
    P J Devereaux
    Population Health Research Institute, David Braley Cardiac, Vascular, and Stroke Research Institute, RoomC1 116, Perioperative Medicine and Surgical Research Unit, c o Hamilton General Hospital, 237 Barton Street East, Hamilton, ON, Canada, L8L2X2
    Open Med 5:e193-200. 2011
    ....
  56. ncbi request reprint An emerging consensus on grading recommendations?
    Gordon Guyatt
    McMaster University, Hamilton, Ontario, Canada
    Evid Based Med 11:2-4. 2006
  57. doi request reprint A new 'mechanistic-practical" framework for designing and interpreting randomized trials
    Paul J Karanicolas
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Ontario, Canada
    J Clin Epidemiol 62:479-84. 2009
    ..e., the conventional pragmatic trial. Instead we will design, implement, and apply the results of practical trials to our patients...
  58. ncbi request reprint Using alternative statistical formats for presenting risks and risk reductions
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, ECMC CC 142, 462 Grider Street, Buffalo, NY, USA, 14215
    Cochrane Database Syst Rev 3:CD006776. 2011
    ..The success of evidence-based practice depends on the clear and effective communication of statistical information...
  59. ncbi request reprint How can quality of life researchers make their work more useful to health workers and their patients?
    Gordon Guyatt
    CLARITY Research Group, Department of Clinical Epidemiology and Biostatistics, Health Sciences Centre, McMaster University, 1200 Main Street West, Rm HSC 2C12, Hamilton, ON, Canada, L8N 3Z5
    Qual Life Res 16:1097-105. 2007
    ..These reporting approaches, as well as ensuring access to data from individual items, will also help those developing decision aids to use quality of life data...
  60. ncbi request reprint Grading strength of recommendations and quality of evidence in clinical guidelines: report from an american college of chest physicians task force
    Gordon Guyatt
    Department of Medicine, HSC 2C12, McMaster University, 1200 Main St West, Hamilton, ON, Canada L8N 3Z5
    Chest 129:174-81. 2006
    ..The trend toward uniformity of approaches to grading will enhance the usefulness of practice guidelines for clinicians...
  61. ncbi request reprint Effect of bisphosphonates on periprosthetic bone mineral density after total joint arthroplasty. A meta-analysis
    Mohit Bhandari
    Department of Clinical Epidemiology and Biostatistics, McMaster University Health Sciences Center, Room 2C9, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada
    J Bone Joint Surg Am 87:293-301. 2005
    ....
  62. ncbi request reprint Anticoagulation for the long-term treatment of venous thromboembolism in patients with cancer
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, ECMC CC 142, 462 Grider Street, Buffalo, NY, USA, 14215
    Cochrane Database Syst Rev 6:CD006650. 2011
    ..Cancer increases the risk of thromboembolic events even while on anticoagulation...
  63. doi request reprint Prognostic value of troponin and creatine kinase muscle and brain isoenzyme measurement after noncardiac surgery: a systematic review and meta-analysis
    Michael Levy
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Anesthesiology 114:796-806. 2011
    ..There is uncertainty regarding the prognostic value of troponin and creatine kinase muscle and brain isoenzyme measurements after noncardiac surgery...
  64. ncbi request reprint An emerging consensus on grading recommendations?
    Gordon Guyatt
    McMaster University, Hamilton, Ontario, Canada
    ACP J Club 144:A8-9. 2006
  65. pmc Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation-2 (STOPIT-2)
    Matthias Briel
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Trials 10:49. 2009
    ..The aim of STOPIT-2 is to determine the magnitude and determinants of possible bias introduced by stopping RCTs early for benefit...
  66. ncbi request reprint Oral anticoagulation in patients with cancer who have no therapeutic or prophylactic indication for anticoagulation
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, ECMC CC 142, 462 Grider Street, Buffalo, NY, USA, 14215
    Cochrane Database Syst Rev 12:CD006466. 2010
    ..A number of basic research and clinical studies have led to the hypothesis that oral anticoagulants may improve the survival of patients with cancer through an antitumor effect in addition to their antithrombotic effect...
  67. ncbi request reprint Parenteral anticoagulation in patients with cancer who have no therapeutic or prophylactic indication for anticoagulation
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, ECMC CC 142, 462 Grider Street, Buffalo, NY, USA, 14215
    Cochrane Database Syst Rev 1:CD006652. 2011
    ..Anticoagulation may improve survival in patients with cancer through an antitumor effect in addition to the perceived antithrombotic effect...
  68. doi request reprint GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables
    Gordon Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Clin Epidemiol 64:383-94. 2011
    ..Subsequent articles in this series will address GRADE's approach to formulating questions, assessing quality of evidence, and developing recommendations...
  69. doi request reprint GRADE guidelines: a new series of articles in the Journal of Clinical Epidemiology
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Clin Epidemiol 64:380-2. 2011
    ..gradeworkinggroup.org/), attests to the importance of this work. This article introduces a 20-part series providing guidance for the use of GRADE methodology that will appear in the Journal of Clinical Epidemiology...
  70. doi request reprint GRADE guidelines: 4. Rating the quality of evidence--study limitations (risk of bias)
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Clin Epidemiol 64:407-15. 2011
    ..Rather, for any individual outcome, when there are some studies with a high risk, and some with a low risk of bias, they should consider including only the studies with a lower risk of bias...
  71. doi request reprint GRADE guidelines: 2. Framing the question and deciding on important outcomes
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Clin Epidemiol 64:395-400. 2011
    ....
  72. pmc GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada L8N 3Z5
    BMJ 336:924-6. 2008
  73. ncbi request reprint Addressing resource allocation issues in recommendations from clinical practice guideline panels: suggestions from an American College of Chest Physicians task force
    Gordon Guyatt
    Department of Medicine, HSC 2C12, McMaster University, 1200 Main St West, Hamilton, ON, Canada L8N 3Z5
    Chest 129:182-7. 2006
    ....
  74. ncbi request reprint Is blinding the endoscopists to bowel preparations in randomized-controlled trials a reality?
    Samer El-Dika
    Department of Medicine, Veterans Affairs Medical Center, Salem, VA 24153, USA
    Cancer Detect Prev 30:552-9. 2006
    ..The primary aim of this study was to explore whether endoscopists can be effectively blinded to the type of bowel preparation...
  75. doi request reprint World Health Organization Guidelines: Use of cryotherapy for cervical intraepithelial neoplasia
    Nancy Santesso
    Department of Clinical Epidemiology and Biostatistics, McMaster University Health Sciences Centre, Hamilton, Canada
    Int J Gynaecol Obstet 118:97-102. 2012
    ..In 2009, the World Health Organization (WHO) committed to updating recommendations for use of cryotherapy for cervical intraepithelial neoplasia (CIN)...
  76. pmc Association between industry funding and statistically significant pro-industry findings in medical and surgical randomized trials
    Mohit Bhandari
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ont
    CMAJ 170:477-80. 2004
    ..In this study, we examine the association between industry funding and the statistical significance of results in recently published medical and surgical trials...
  77. pmc Detecting myocardial infarction in critical illness using screening troponin measurements and ECG recordings
    Wendy Lim
    Department of Medicine, McMaster University, Canada
    Crit Care 12:R36. 2008
    ..This is a prospective screening study...
  78. ncbi request reprint Prolongation of the QT-corrected interval during dobutamine stress echocardiography: a marker for ischemia
    Tushar Vora
    Department of Medicine, Cardiology Division, State University of New York at Buffalo, Buffalo, NY, USA
    Coron Artery Dis 14:233-7. 2003
    ..Dobutamine stress echocardiography (DSE) has become a very reliable non-invasive tool in the diagnosis of ischemic heart disease based on the determination of new wall motion abnormalities rather than electrocardiographic changes...
  79. ncbi request reprint A plant food-based diet modifies the serum beta-sitosterol concentration in hyperandrogenic postmenopausal women
    Paola Muti
    Department of Social and Preventive Medicine, University at Buffalo, Buffalo, NY, USA
    J Nutr 133:4252-5. 2003
    ..These findings indicate that phytosterols, in particular beta-sitosterol, can be used as biomarkers of exposure in observational studies or as compliance indicators in dietary intervention studies of cancer prevention...