Research Topics
| Barbara SchmidtSummaryAffiliation: McMaster University Country: Canada Publications
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Publications
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infantsB Schmidt
Department of Pediatrics, McMaster University, Hamilton, Ont, Canada
N Engl J Med 344:1966-72. 2001..Whether prophylaxis with indomethacin confers any long-term benefits that outweigh the risks of drug-induced reductions in renal, intestinal, and cerebral blood flow is not known...- Long-term effects of caffeine therapy for apnea of prematurityBarbara Schmidt
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
N Engl J Med 357:1893-902. 2007..Methylxanthine therapy is commonly used for apnea of prematurity but in the absence of adequate data on its efficacy and safety. It is uncertain whether methylxanthines have long-term effects on neurodevelopment and growth... - Indomethacin prophylaxis, patent ductus arteriosus, and the risk of bronchopulmonary dysplasia: further analyses from the Trial of Indomethacin Prophylaxis in Preterms (TIPP)Barbara Schmidt
Department of Pediatrics and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
J Pediatr 148:730-734. 2006.... - Caffeine therapy for apnea of prematurityBarbara Schmidt
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ont, Canada
N Engl J Med 354:2112-21. 2006..It is uncertain whether methylxanthines have other short- and long-term benefits or risks in infants with very low birth weight... 
Survival without disability to age 5 years after neonatal caffeine therapy for apnea of prematurityBarbara Schmidt
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
JAMA 307:275-82. 2012..Very preterm infants are prone to apnea and have an increased risk of death or disability. Caffeine therapy for apnea of prematurity reduces the rates of cerebral palsy and cognitive delay at 18 months of age...- Methylxanthine therapy for apnea of prematurity: evaluation of treatment benefits and risks at age 5 years in the international Caffeine for Apnea of Prematurity (CAP) trialBarbara Schmidt
Department of Pediatrics, McMaster University, Hamilton, Canada
Biol Neonate 88:208-13. 2005..Once this project is completed, caffeine will be one of the most rigorously evaluated neonatal therapies... - Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in pretermsBarbara Schmidt
Department of Pediatrics, McMaster University, HSC 3N11E, 1200 Main St W, Hamilton, Ontario, Canada L8N 3Z5
JAMA 289:1124-9. 2003..Despite more than 2 decades of outcomes research after very preterm birth, clinicians remain uncertain about the extent to which neonatal morbidities predict poor long-term outcomes of extremely low-birth-weight (ELBW) infants... - Male/female differences in indomethacin effects in preterm infantsArne Ohlsson
University of Toronto, Toronto, McMaster University, Hamilton, Ontario, Canada
J Pediatr 147:860-2. 2005..A secondary analysis was performed in the entire "Trial of Indomethacin Prophylaxis in Preterms study" cohort. The results suggest a weak differential treatment effect of indomethacin by sex... - Neurosensory impairment after surgical closure of patent ductus arteriosus in extremely low birth weight infants: results from the Trial of Indomethacin Prophylaxis in PretermsNandkishor S Kabra
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
J Pediatr 150:229-34, 234.e1. 2007.... - Prevention and 18-month outcomes of serious pulmonary hemorrhage in extremely low birth weight infants: results from the trial of indomethacin prophylaxis in pretermsKhalid Alfaleh
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
Pediatrics 121:e233-8. 2008..We also compared the 18-month outcomes of infants with and without a serious pulmonary bleed... 
Using a count of neonatal morbidities to predict poor outcome in extremely low birth weight infants: added role of neonatal infectionDirk Bassler
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
Pediatrics 123:313-8. 2009..Neonatal infection has also been linked with later impairment. We examined whether the addition of infection to the count of 3 neonatal morbidities further improves the prediction of poor outcome...- Controversies surrounding xanthine therapyDavid Millar
Department of Paediatrics, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
Semin Neonatol 9:239-44. 2004..An international controlled clinical trial is underway to examine the long-term efficacy and safety of methylxanthine therapy in very low birth weight babies... - Heat Loss Prevention (HeLP) in the delivery room: A randomized controlled trial of polyethylene occlusive skin wrapping in very preterm infantsSunita Vohra
Department of Pediatrics, McMaster University, the Children's Hospital of Hamilton Health Sciences, Hamilton, Ontario, Canada
J Pediatr 145:750-3. 2004..21 degrees C (95% CI, 0.04 to 0.4) with each 100-g increase in birth weight. CONCLUSIONS: Polyethylene occlusive skin wrapping prevents rather than delays heat loss at delivery in very preterm infants... - Evidence-based neonatology: making a difference beyond discharge from the neonatal nurseryJoAnn Harrold
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
Curr Opin Pediatr 14:165-9. 2002..Thyroxine supplementation for premature infants and head cooling for asphyxiated term infants require further study and should not be prescribed outside of rigorous clinical trials... - Positive end-expiratory pressure above lower inflection point minimizes influx of activated neutrophils into lungShelley L Monkman
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
Crit Care Med 32:2471-5. 2004..019). CONCLUSIONS: PEEP set above the LIP on the inspiratory limb of the pressure-volume curve affords a stronger lung protection than VT strategy... - Antithrombin replacement in neonates: is there any indication?Dirk Bassler
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
Thromb Res 118:107-11. 2006..It has been hypothesised that treatment of the acquired AT deficiency with AT concentrate may improve the outcome of conditions such as the neonatal respiratory distress syndrome (RDS), intracranial hemorrhage (ICH) and sepsis... - Evidence-based neonatal drug therapy for prevention of bronchopulmonary dysplasia in very-low-birth-weight infantsBarbara Schmidt
Department of Pediatrics, Children s Hospital of Philadelphia and The University of Pennsylvania, Philadelphia, PA 19104, USA
Neonatology 93:284-7. 2008..However, when given during the 2nd week of life to infants at high risk of BPD corticosteroids may have important short- and long-term benefits. These should be urgently confirmed or refuted in well-designed controlled trials... - Evaluating "old" definitions for the "new" bronchopulmonary dysplasiaPeter G Davis
Department of Paediatrics, Royal Women's Hospital, Melbourne, Victoria, Australia
J Pediatr 140:555-60. 2002..CONCLUSIONS: Poor pulmonary outcome and poor neurosensory outcome are common late adverse outcomes in this population. BPD as defined by duration of oxygen therapy is a less accurate surrogate currently than in previous eras... - Retrospective economic evaluation of a controlled trial of indomethacin prophylaxis for patent ductus arteriosus in premature infantsJohn A F Zupancic
Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Early Hum Dev 82:97-103. 2006..To determine the incremental cost-effectiveness of indomethacin prophylaxis in extremely low birth weight infants enrolled in the Trial of Indomethacin Prophylaxis in Preterms (TIPP)... - Ibuprofen prophylaxis in preterm neonatesBarbara Schmidt
Lancet 360:492. 2002 - Daily cost prediction model in neonatal intensive careJohn A F Zupancic
Department of Neonatology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA 02458, USA
Int J Technol Assess Health Care 19:330-8. 2003..To reduce this data collection burden, we identified the key resource items that predict daily ancillary costs for extremely low birth weight infants... - A novel model of selective lung ventilation to investigate the long-term effects of ventilation-induced lung injuryTorsten Schreiber
Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller Universitaet Jena, Jena, Germany
Shock 26:50-4. 2006..This animal model permits assessment of the long-term course of ventilation-induced lung injury and shows that pulmonary inflammation and histological alterations are present 24 h after unilateral injurious ventilation... - Effects of a catecholamine-induced increase in cardiac output on lung injury after experimental unilateral pulmonary acid instillationTorsten Schreiber
Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller Universitat Jena, Jena, Germany
Crit Care Med 35:1741-8. 2007..We sought to determine the effects of increased cardiac output on markers of lung injury in an in vivo model of inhomogeneous lung perfusion and injury... - Preemie abandonment? Multidisciplinary experts consider how to best meet preemies needs at "preterm infants: a collaborative approach to specialized care" roundtableHeidelise Als
Harvard Medical School Children s Hospital, Boston, USA
Mod Healthc 37:17-24. 2007.... - PEEP has beneficial effects on inflammation in the injured and no deleterious effects on the noninjured lung after unilateral lung acid instillationTorsten Schreiber
Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University, Erlanger Allee 101, 07747, Jena, Germany
Intensive Care Med 32:740-9. 2006..We compared the effects of PEEP on the inflammatory response in injured and noninjured regions of the lung in an animal model of unilateral lung acid instillation... - Increased susceptibility to ventilator-associated lung injury persists after clinical recovery from experimental endotoxemiaTorsten Schreiber
Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller Universitaet, Jena, Germany
Anesthesiology 104:133-41. 2006..However, it is unclear whether increased susceptibility to ventilator-associated lung injury is still present after clinical recovery from a transient endotoxin challenge... - Sustaining better diabetes care in remote indigenous Australian communitiesRobyn McDermott
Tropical Public Health Unit, Queensland Health, Cairns, QLD 4870, Australia
BMJ 327:428-30. 2003..This study looked at whether those improvements were sustained two years after the end of the trial...