Guillaume Pare

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. doi request reprint Genetic determinants of dabigatran plasma levels and their relation to bleeding
    Guillaume Pare
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, David Braley Cardiac Vascular and Stroke Research Institute, 237 Barton St E, Room C3 103, Hamilton, ON, Canada L8L 2X2
    Circulation 127:1404-12. 2013
  2. doi request reprint Effect of PON1 Q192R genetic polymorphism on clopidogrel efficacy and cardiovascular events in the Clopidogrel in the Unstable Angina to Prevent Recurrent Events trial and the Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascula
    Guillaume Pare
    Population Health Research Institute, Hamilton Health Sciences and Departments of Medicine, Epidemiology, and Pathology, McMaster University, Hamilton, Ontario, Canada
    Circ Cardiovasc Genet 5:250-6. 2012
  3. pmc Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci
    Guillaume Pare
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1001374. 2011
  4. doi request reprint Effects of CYP2C19 genotype on outcomes of clopidogrel treatment
    Guillaume Pare
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 363:1704-14. 2010
  5. pmc On the use of variance per genotype as a tool to identify quantitative trait interaction effects: a report from the Women's Genome Health Study
    Guillaume Pare
    Department of Pathology and Molecular Medicine, Population Genomics Program, McMaster University, Hamilton, Canada
    PLoS Genet 6:e1000981. 2010
  6. doi request reprint Genome-wide association studies--data generation, storage, interpretation, and bioinformatics
    Guillaume Pare
    Department of Pathology and Molecular Medicine, Genetic and Molecular Epidemiology Laboratory, McMaster University, 1200 Main St West MDCL Rm 3206, Hamilton, ON, Canada, L8N 3Z5
    J Cardiovasc Transl Res 3:183-8. 2010
  7. pmc Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study
    Jacqueline S Danik
    Center for Cardiovascular Disease Prevention, Donald W Reynolds Center for Cardiovascular Research, and Translational Medicine Division, Brigham and Women s Hospital, 900 Commonwealth Ave East, Boston, MA 02215, USA
    Circ Cardiovasc Genet 2:134-41. 2009
  8. pmc Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication
    Daniel I Chasman
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circ Cardiovasc Genet 1:21-30. 2008
  9. pmc Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women
    Guillaume Pare
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000118. 2008
  10. pmc Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health Study
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, The Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circ Cardiovasc Genet 2:26-33. 2009

Detail Information

Publications28

  1. doi request reprint Genetic determinants of dabigatran plasma levels and their relation to bleeding
    Guillaume Pare
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, David Braley Cardiac Vascular and Stroke Research Institute, 237 Barton St E, Room C3 103, Hamilton, ON, Canada L8L 2X2
    Circulation 127:1404-12. 2013
    ..We hypothesized that genetic variants could contribute to interindividual variability in blood concentrations of the active metabolite of dabigatran etexilate and influence the safety and efficacy of dabigatran...
  2. doi request reprint Effect of PON1 Q192R genetic polymorphism on clopidogrel efficacy and cardiovascular events in the Clopidogrel in the Unstable Angina to Prevent Recurrent Events trial and the Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascula
    Guillaume Pare
    Population Health Research Institute, Hamilton Health Sciences and Departments of Medicine, Epidemiology, and Pathology, McMaster University, Hamilton, Ontario, Canada
    Circ Cardiovasc Genet 5:250-6. 2012
    ....
  3. pmc Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci
    Guillaume Pare
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1001374. 2011
    ..These associations provide insights into the genetic regulation of sICAM-1 levels and implicate these loci in the regulation of endothelial function...
  4. doi request reprint Effects of CYP2C19 genotype on outcomes of clopidogrel treatment
    Guillaume Pare
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 363:1704-14. 2010
    ....
  5. pmc On the use of variance per genotype as a tool to identify quantitative trait interaction effects: a report from the Women's Genome Health Study
    Guillaume Pare
    Department of Pathology and Molecular Medicine, Population Genomics Program, McMaster University, Hamilton, Canada
    PLoS Genet 6:e1000981. 2010
    ..These results demonstrate the utility of our approach and provide novel genetic insight into the relationship among obesity, smoking, and inflammation...
  6. doi request reprint Genome-wide association studies--data generation, storage, interpretation, and bioinformatics
    Guillaume Pare
    Department of Pathology and Molecular Medicine, Genetic and Molecular Epidemiology Laboratory, McMaster University, 1200 Main St West MDCL Rm 3206, Hamilton, ON, Canada, L8N 3Z5
    J Cardiovasc Transl Res 3:183-8. 2010
    ..GWAS data generation, analysis, and interpretation will be covered...
  7. pmc Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study
    Jacqueline S Danik
    Center for Cardiovascular Disease Prevention, Donald W Reynolds Center for Cardiovascular Research, and Translational Medicine Division, Brigham and Women s Hospital, 900 Commonwealth Ave East, Boston, MA 02215, USA
    Circ Cardiovasc Genet 2:134-41. 2009
    ..Despite evidence of crucial biological function and moderate heritability, comprehensive analysis of the influence of genetic variation on fibrinogen is not available...
  8. pmc Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication
    Daniel I Chasman
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circ Cardiovasc Genet 1:21-30. 2008
    ....
  9. pmc Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women
    Guillaume Pare
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000118. 2008
    ..2) locus is highly correlated with sICAM-1 concentrations. The novel association at the ABO locus provides evidence for a previously unknown regulatory role of histo-blood group antigens in inflammatory adhesion processes...
  10. pmc Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health Study
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, The Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circ Cardiovasc Genet 2:26-33. 2009
    ..One method to evaluate this issue is to examine whether polymorphisms in the CETP gene that impact on HDL-C levels also impact on the future development of myocardial infarction...
  11. ncbi request reprint The relationship between CYP2C19 polymorphisms and ischaemic and bleeding outcomes in stable outpatients: the CHARISMA genetics study
    Deepak L Bhatt
    VA Boston Healthcare System, Brigham and Women s Hospital, and Harvard Medical School, 1400 VFW Parkway, Boston, MA 02132, USA
    Eur Heart J 33:2143-50. 2012
    ..We sought to determine the impact of CYP2C19 polymorphisms on ischaemic and bleeding events...
  12. pmc Association between a literature-based genetic risk score and cardiovascular events in women
    Nina P Paynter
    Center for Cardiovascular Disease Prevention and the Divisions of Preventive Medicine and Cardiovascular Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
    JAMA 303:631-7. 2010
    ..While multiple genetic markers associated with cardiovascular disease have been identified by genome-wide association studies, their aggregate effect on risk beyond traditional factors is uncertain, particularly among women...
  13. pmc Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study
    Guillaume Pare
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    PLoS Genet 4:e1000312. 2008
    ..This observed genetic association between glycated hemoglobin levels and HK1 polymorphisms paves the way for further studies of the role of HK1 in hemoglobin glycation, glucose metabolism, and diabetes...
  14. pmc Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study
    Guillaume Pare
    Center for Cardiovascular Disease Prevention and the Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215, USA
    Circ Cardiovasc Genet 2:142-50. 2009
    ..Although genetic variants of MTHFR and CBS are known to influence homocysteine concentration, common genetic determinants of homocysteine remain largely unknown...
  15. doi request reprint Genetic variants associated with myocardial infarction risk factors in over 8000 individuals from five ethnic groups: The INTERHEART Genetics Study
    Sonia S Anand
    Population Health Research Institute, Hamilton Health Sciences, Ontario, Canada
    Circ Cardiovasc Genet 2:16-25. 2009
    ..Myocardial infarction (MI) is a leading cause of death globally, but specific genetic variants that influence MI and MI risk factors have not been assessed on a global basis...
  16. pmc Candidate genetic variants in the fibrinogen, methylenetetrahydrofolate reductase, and intercellular adhesion molecule-1 genes and plasma levels of fibrinogen, homocysteine, and intercellular adhesion molecule-1 among various race/ethnic groups: data from
    Michelle A Albert
    Center for Cardiovascular Disease Prevention, Donald W Reynolds Center for Cardiovascular Disease Research, Brigham and Women s Hospital, Harvard Medical School, Boston MA, USA
    Am Heart J 157:777-83.e1. 2009
    ..We examined the relationship between specific polymorphisms in the FGB, homocysteine, and ICAM-1 genes and their respective inflammatory biomarker concentrations at baseline in women from different race/ethnic groups...
  17. pmc Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis
    Daniel I Chasman
    Donald W Reynolds Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS Genet 5:e1000730. 2009
    ....
  18. pmc BRCA2 variants and cardiovascular disease in a multi-ethnic study
    Kevin Zbuk
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    BMC Med Genet 13:56. 2012
    ..We therefore tested the association of BRCA2 variants with clinical cardiovascular disease (CVD)...
  19. doi request reprint Genetic markers of inflammation and their role in cardiovascular disease
    Kripa Raman
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada
    Can J Cardiol 29:67-74. 2013
    ..The markers selected for this review include C-reactive protein, soluble intercellular adhesion molecule-1, interleukin-6, and P-selectin...
  20. pmc Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 82:1185-92. 2008
    ....
  21. pmc Genome-wide association studies identify loci associated with age at menarche and age at natural menopause
    Chunyan He
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Genet 41:724-8. 2009
    ..42 (in or near the gene BRSK1), 5q35.2 (in or near genes UIMC1 and HK3) and 6p24.2 (in the gene SYCP2L). These newly identified loci might expand understanding of the biological pathways regulating these two traits...
  22. doi request reprint Population-based genomewide genetic analysis of common clinical chemistry analytes
    Daniel I Chasman
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Clin Chem 55:39-51. 2009
    ..These early studies have also led to development of a set of principles for conducting a successful genomewide association study (GWAS)...
  23. doi request reprint Genetic variants associated with angiotensin-converting enzyme inhibitor-associated angioedema
    Guillaume Pare
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Pharmacogenet Genomics 23:470-8. 2013
    ..The objective of this study was to identify genetic variants associated with angiotensin-converting enzyme (ACE) inhibitor-associated angioedema...
  24. doi request reprint Pharmacogenetics in Cardiovascular Disease: The Challenge of Moving From Promise to Realization: Concepts Discussed at the Canadian Network and Centre for Trials Internationally Network Conference (CANNeCTIN), June 2009
    Philip G Joseph
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton
    Clin Cardiol 37:48-56. 2014
    ....
  25. pmc Genetic information and the prediction of incident type 2 diabetes in a high-risk multiethnic population: the EpiDREAM genetic study
    Sonia S Anand
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton General Hospital, Hamilton, Ontario, Canada
    Diabetes Care 36:2836-42. 2013
    ....
  26. doi request reprint Exploring gene-environment relationships in cardiovascular disease
    Philip G Joseph
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Can J Cardiol 29:37-45. 2013
    ..This review will examine the current evidence supporting gene-environment interactions in cardiometabolic diseases, and highlight additional steps that are needed to determine the clinical utility of these observations...
  27. doi request reprint Pharmacogenetics of antiplatelets and anticoagulants: a report on clopidogrel, warfarin and dabigatran
    Stephanie Ross
    Population Health Research Institute, McMaster University, Hamilton General Hospital Campus, DB CVSRI, 237 Barton Street East, Room C3103, Hamilton, ON L8L 2X2, Canada
    Pharmacogenomics 14:1565-72. 2013
    ..We will focus on common genetic variants that influence the absorption, metabolism and/or action of these agents, including CYP2C19 (*2, *3 and *17), CYP3A4, CYP3A5, CYP2C9, ABCB1, P2RY12, CYP2C9 (*2/*3), VKORC1 and CESI. ..
  28. pmc Interpreting metabolomic profiles using unbiased pathway models
    Rahul C Deo
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Comput Biol 6:e1000692. 2010
    ..Given the involvement of transporters in human disease, metabolite profiling may contribute to improved disease classification via the interrogation of specific transporter activities...