Paul M O'Byrne

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. pmc Allergen-induced airway inflammation and its therapeutic intervention
    Paul M O'Byrne
    Firestone Institute for Respiratory Health, St Joseph s Hospital and the Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Allergy Asthma Immunol Res 1:3-9. 2009
  2. pmc Once-daily fluticasone furoate alone or combined with vilanterol in persistent asthma
    Paul M O'Byrne
    Hamilton, ON, Canada
    Eur Respir J 43:773-82. 2014
  3. pmc Decreased miR-192 expression in peripheral blood of asthmatic individuals undergoing an allergen inhalation challenge
    Masatsugu Yamamoto
    UBC James Hogg Research Centre, St Paul s Hospital, University of British Columbia, Room 166, Burrard Building, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    BMC Genomics 13:655. 2012
  4. pmc Role of monoclonal antibodies in the treatment of asthma
    Paul M O'Byrne
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Can Respir J 20:23-5. 2013
  5. doi request reprint The poorly explored impact of uncontrolled asthma
    Paul M O'Byrne
    Firestone Institute of Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, ON, Canada
    Chest 143:511-23. 2013
  6. doi request reprint Risk of new onset diabetes mellitus in patients with asthma or COPD taking inhaled corticosteroids
    P M O'Byrne
    Firestone Institute of Respiratory Health, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Respir Med 106:1487-93. 2012
  7. ncbi request reprint Severe asthma: future treatments
    P M O'Byrne
    Firestone Institute for Respiratory Health, St Joseph s Hospital and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin Exp Allergy 42:706-11. 2012
  8. pmc Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps
    Eric D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Respir Res 12:38. 2011
  9. doi request reprint Measuring asthma control: a comparison of three classification systems
    P M O'Byrne
    Michael G DeGroote School of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    Eur Respir J 36:269-76. 2010
  10. doi request reprint Obstructive lung disease from conception to old age: differences in the treatment of adults and children with asthma
    Paul M O'Byrne
    Firestone Institute for Respiratory Health, St Joseph s Hospital and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Proc Am Thorac Soc 6:720-3. 2009

Detail Information

Publications91

  1. pmc Allergen-induced airway inflammation and its therapeutic intervention
    Paul M O'Byrne
    Firestone Institute for Respiratory Health, St Joseph s Hospital and the Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Allergy Asthma Immunol Res 1:3-9. 2009
    ..In addition, allergen inhalation challenge has become a useful method which can, in a very limited number of patients, provide key information on the therapeutic potential of new drugs being developed to treat asthma...
  2. pmc Once-daily fluticasone furoate alone or combined with vilanterol in persistent asthma
    Paul M O'Byrne
    Hamilton, ON, Canada
    Eur Respir J 43:773-82. 2014
    ..FF/VI resulted in statistically greater improvements in lung function and symptomatic end-points versus FF, and was well tolerated in this asthma population...
  3. pmc Decreased miR-192 expression in peripheral blood of asthmatic individuals undergoing an allergen inhalation challenge
    Masatsugu Yamamoto
    UBC James Hogg Research Centre, St Paul s Hospital, University of British Columbia, Room 166, Burrard Building, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    BMC Genomics 13:655. 2012
    ..We aimed to evaluate changes in the microRNA profiles in the peripheral blood of asthmatic subjects undergoing allergen inhalation challenge...
  4. pmc Role of monoclonal antibodies in the treatment of asthma
    Paul M O'Byrne
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Can Respir J 20:23-5. 2013
    ..New treatment approaches developed to manage some of the phenotypes of severe refractory asthma have included humanized monoclonal antibodies (hMabs)...
  5. doi request reprint The poorly explored impact of uncontrolled asthma
    Paul M O'Byrne
    Firestone Institute of Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, ON, Canada
    Chest 143:511-23. 2013
    ..The maintenance of asthma control has significant advantages to patients and greatly outweighs the potential risks of treatment side effects...
  6. doi request reprint Risk of new onset diabetes mellitus in patients with asthma or COPD taking inhaled corticosteroids
    P M O'Byrne
    Firestone Institute of Respiratory Health, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Respir Med 106:1487-93. 2012
    ..A recent case-controlled study reported an increased risk of diabetes mellitus in patients treated with inhaled corticosteroids for asthma or COPD, versus age-matched controls...
  7. ncbi request reprint Severe asthma: future treatments
    P M O'Byrne
    Firestone Institute for Respiratory Health, St Joseph s Hospital and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin Exp Allergy 42:706-11. 2012
    ..Patients with severe refractory asthma have not achieved asthma control, even with high doses of ICS, usually in combination with LABAs and other maintenance treatments...
  8. pmc Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps
    Eric D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Respir Res 12:38. 2011
    ....
  9. doi request reprint Measuring asthma control: a comparison of three classification systems
    P M O'Byrne
    Michael G DeGroote School of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    Eur Respir J 36:269-76. 2010
    ..GINA Controlled/Partly Controlled and GOAL Totally Controlled/Well-Controlled correspond to ACQ-5 <1.00. The ACQ-5 is more responsive to change in a clinical trial setting than a categorical scale...
  10. doi request reprint Obstructive lung disease from conception to old age: differences in the treatment of adults and children with asthma
    Paul M O'Byrne
    Firestone Institute for Respiratory Health, St Joseph s Hospital and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Proc Am Thorac Soc 6:720-3. 2009
    ..Inhaled corticosteroid/long-acting inhaled beta(2)-agonist combinations may not be as effective in children as in they are adults in improving asthma control and reducing asthma exacerbations...
  11. ncbi request reprint Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma
    Paul M O'Byrne
    Firestone Institute for Respiratory Health, St Joseph s Hospital, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 171:129-36. 2005
    ..001), reduced severe exacerbation rate, and improved symptoms, awakenings, and lung function compared with both fixed dosing regimens...
  12. doi request reprint Prolonged bronchoprotection against inhaled methacholine by inhaled BI 1744, a long-acting beta(2)-agonist, in patients with mild asthma
    Paul M O'Byrne
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 124:1217-21. 2009
    ..Long-acting ss(2)-agonists are an established controller medication in asthma. BI 1744 is a novel L\long-acting ss(2)-agonist with a preclinical profile that suggests 24-hour bronchodilation and bronchoprotection may be achieved...
  13. ncbi request reprint Initiation, dose reduction, and duration of inhaled corticosteroid therapy
    Paul M O'Byrne
    Firestone Institute for Respiratory Health, St Joseph s Hospital and McMaster University, 1200 Main Street West, Hamilton, Ontario L9G 4R7, Canada
    Immunol Allergy Clin North Am 25:511-21, vi. 2005
    ..For this reason, pharmacologic treatment to reduce airway inflammation is currently the cornerstone of therapy for most individuals who have asthma...
  14. doi request reprint The effects of inhaled budesonide on lung function in smokers and nonsmokers with mild persistent asthma
    Paul M O'Byrne
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Chest 136:1514-20. 2009
    ..The objective of this post hoc study was to study the effects of low-dose inhaled budesonide on lung function in smokers and nonsmokers with mild persistent asthma...
  15. ncbi request reprint Increasing doses of inhaled corticosteroids compared to adding long-acting inhaled beta2-agonists in achieving asthma control
    Paul M O'Byrne
    Department of Medicine, McMaster, Hamilton, ON, Canada
    Chest 134:1192-9. 2008
    ..However, it is not known which of these treatment options is more effective in sustaining asthma control...
  16. doi request reprint Efficacy of leukotriene receptor antagonists and synthesis inhibitors in asthma
    Paul M O'Byrne
    Department of Medicine, McMaster University, Firestone Institute for Respiratory Health, St Joseph s Healthcare, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 124:397-403. 2009
    ..Leukotriene receptor antagonists have an excellent safety profile...
  17. ncbi request reprint Exacerbations of asthma and COPD: definitions, clinical manifestations and epidemiology
    Paul M O'Byrne
    Firestone Institute for Respiratory Health, St Joseph s Hospital, Hamilton, Ontario, Canada
    Contrib Microbiol 14:1-11. 2007
    ..The similarities and differences between exacerbations asthma and COPD with an emphasis on epidemiology and clinical presentation are discussed and compared in this chapter...
  18. ncbi request reprint Effects of early intervention with inhaled budesonide on lung function in newly diagnosed asthma
    Paul M O'Byrne
    Department of Medicine, McMaster University Medical Center, 1200 Main St West, Hamilton, ON, Canada
    Chest 129:1478-85. 2006
    ..Asthmatic patients lose lung function faster than normal subjects. The effectiveness of early intervention with inhaled corticosteroids on this decline in lung function is not established in recent-onset disease...
  19. doi request reprint Provoked models of asthma: what have we learnt?
    P M O'Byrne
    Firestone Institute for Respiratory Health, St Joseph s Hospital, Hamilton, ON, Canada
    Clin Exp Allergy 39:181-92. 2009
    ..An emerging role for measurements of AHR is in the evaluation of the optimal treatment for patients with asthma...
  20. ncbi request reprint Cytokines or their antagonists for the treatment of asthma
    Paul M O'Byrne
    McMaster University, Hamilton, ON, Canada
    Chest 130:244-50. 2006
    ....
  21. ncbi request reprint Pharmacological management of mild or moderate persistent asthma
    Paul M O'Byrne
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Lancet 368:794-803. 2006
    ..For patients who do not achieve asthma control despite taking drugs, measurement of the inflammatory response in the airway in induced sputum could provide further information to guide treatment...
  22. doi request reprint Severe exacerbations and decline in lung function in asthma
    Paul M O'Byrne
    Department of Medicine, McMaster University Medical Center, Ontario, Canada
    Am J Respir Crit Care Med 179:19-24. 2009
    ..To evaluate the association between asthma exacerbations and the decline in lung function, as well as the potential effects of an inhaled corticosteroid, budesonide, on exacerbation-related decline in patients with asthma...
  23. ncbi request reprint Acute asthma intervention: insights from the STAY study
    Paul M O'Byrne
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 119:1332-6. 2007
    ..The benefit was seen in patients of all ages. Subsequent studies have revealed that this beneficial effect of budesonide/formoterol as maintenance and reliever requires both components of the combination...
  24. ncbi request reprint Reassessing the Th2 cytokine basis of asthma
    Paul M O'Byrne
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare and McMaster University, Hamilton, Ontario L8N 4A6, Canada
    Trends Pharmacol Sci 25:244-8. 2004
    ..Nevertheless, because IL-4 is required for IgE production and IL-5 is required for eosinophilopoesis, these Th2 cytokines must remain important candidates for a role in the pathogenesis of allergic asthma...
  25. doi request reprint Therapeutic strategies to reduce asthma exacerbations
    Paul M O'Byrne
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, and the Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 128:257-63; quiz 264-5. 2011
    ..In addition, treatment of patients with severe asthma with an anti-IL-5 mAb also reduces the number of severe asthma exacerbations, demonstrating a central role of eosinophils in many exacerbations...
  26. doi request reprint Risks of pneumonia in patients with asthma taking inhaled corticosteroids
    Paul M O'Byrne
    Firestone Institute for Respiratory Health, Michael G DeGroote School of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 183:589-95. 2011
    ..Studies in chronic obstructive pulmonary disease reported increased rates of pneumonia with ICS. Concerns exist about an increased pneumonia risk in patients with asthma taking ICS...
  27. ncbi request reprint Pharmacologic interventions to reduce the risk of asthma exacerbations
    Paul M O'Byrne
    Firestone Institute for Respiratory Health, St Joseph s Hospital, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada
    Proc Am Thorac Soc 1:105-8. 2004
    ..Treatment with either leukotriene receptor antagonists or anti-IgE also reduces the risks of asthma exacerbations, but the magnitude of the benefit compared with the combination of ICS and long-acting beta(2)-agonists is not yet known...
  28. ncbi request reprint Introduction: Airway hyperresponsiveness in asthma: its measurement and clinical significance
    Paul M O'Byrne
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, Department of Medicine, McMaster University, Hamilton, ON, Canada
    Chest 138:1S-3S. 2010
    ..There was an additional focus on the indirect measurement of airway inflammation and its interaction with airway hyperresponsiveness, as well as the role of measuring airway inflammation in the management of asthma...
  29. ncbi request reprint Low dose inhaled budesonide and formoterol in mild persistent asthma: the OPTIMA randomized trial
    P M O'Byrne
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 164:1392-7. 2001
    ....
  30. ncbi request reprint Kinetics of bone marrow eosinophilopoiesis and associated cytokines after allergen inhalation
    Sandra C Dorman
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 169:565-72. 2004
    ..We propose that after allergen inhalation, time-dependent changes in cytokine levels in the bone marrow control differentiation of eosinophil/basophil progenitors...
  31. ncbi request reprint Sputum CD34+IL-5Ralpha+ cells increase after allergen: evidence for in situ eosinophilopoiesis
    Sandra C Dorman
    Firestone Institute of Respiratory Health, Asthma Research Group, St Joseph s Healthcare, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 169:573-7. 2004
    ..These results indicate that eosinophil progenitors can migrate to the airways and may differentiate toward an eosinophilic phenotype...
  32. ncbi request reprint Dysfunction and remodeling of the mouse airway persist after resolution of acute allergen-induced airway inflammation
    Richard Leigh
    Firestone Institute for Respiratory Health, Department of Medicine and Center for Gene Therapeutics, Hamilton, Ontario, Canada
    Am J Respir Cell Mol Biol 27:526-35. 2002
    ....
  33. ncbi request reprint Effects of montelukast and budesonide on airway responses and airway inflammation in asthma
    Richard Leigh
    Asthma Research Group, Firestone Institute for Respiratory Health and Department of Medicine, St Joseph s Healthcare McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 166:1212-7. 2002
    ....
  34. ncbi request reprint The effect of pranlukast on allergen-induced bone marrow eosinophilopoiesis in subjects with asthma
    Krishnan Parameswaran
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 169:915-20. 2004
    ..We conclude that, the cysteinyl leukotriene receptor antagonist, pranlukast, attenuates allergen-induced increase in airway eosinophils by decreasing bone marrow eosinophilopoiesis and airway chemotactic and eosinophilopoietic cytokines...
  35. ncbi request reprint Effect of interferon-gamma on allergic airway responses in interferon-gamma-deficient mice
    Makoto Yoshida
    Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, 50 Charlton Avenue East, Hamilton, Ontario, L8N 4A6 Canada
    Am J Respir Crit Care Med 166:451-6. 2002
    ..Observations that IFN-gamma reverses airway responses, even when administered after challenge, suggests that IFN-gamma treatment could control allergic disease, including asthma...
  36. ncbi request reprint The effects of intranasal budesonide on allergen-induced production of interleukin-5 and eotaxin, airways, blood, and bone marrow eosinophilia, and eosinophil progenitor expansion in sensitized mice
    Huahao Shen
    Asthma Research Group, Department of Medicine, McMaster University and St Joseph s Hospital, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 166:146-53. 2002
    ....
  37. ncbi request reprint Increased levels of airway neutrophils reduce the inhibitory effects of inhaled glucocorticosteroids on allergen-induced airway eosinophils
    Gail M Gauvreau
    St Joseph s Hospital and the Department of Medicine, McMaster University, Hamilton, Canada
    Can Respir J 9:26-32. 2002
    ..Treatment with inhaled glucocorticosteroids attenuates allergen-induced airway inflammation but is less effective in people with asthma who have noneosinophilic airway inflammation...
  38. ncbi request reprint Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, ON, Canada
    N Engl J Med 360:985-93. 2009
    ..Secondary objectives were to examine its effect on the number of eosinophils in sputum and blood, symptoms, and airflow limitation...
  39. ncbi request reprint Anti-allergic therapies: effects on eosinophil progenitors
    Adrian J Baatjes
    Asthma Research Group, Department of Medicine, Division of Allergy and Clinical Immunology, HSC 3V46, Canada
    Pharmacol Ther 95:63-72. 2002
    ..Therefore, targeting the systemic hematopoietic response may provide additional, more beneficial, therapeutic effects...
  40. ncbi request reprint Allergen-induced increases in bone marrow T lymphocytes and interleukin-5 expression in subjects with asthma
    Lorna J Wood
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Hospital and the Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 166:883-9. 2002
    ....
  41. ncbi request reprint Sputum eosinophils and the response of exercise-induced bronchoconstriction to corticosteroid in asthma
    Mylinh Duong
    Department of Medicine, McMaster University, 1200 Main St West, Room 3U 24, Hamilton, ON, Canada L8N 3Z5
    Chest 133:404-11. 2008
    ..The relationship between eosinophilic airway inflammation and exercise-induced bronchoconstriction (EIB), and the response to inhaled corticosteroid (ICS) therapy was examined...
  42. ncbi request reprint Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses
    Gail M Gauvreau
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 177:952-8. 2008
    ....
  43. doi request reprint Effects of budesonide and formoterol on allergen-induced airway responses, inflammation, and airway remodeling in asthma
    Margaret M Kelly
    Firestone Institute for Respiratory Health, Department of Medicine, St Joseph s Healthcare and McMaster University Medical Center, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Allergy Clin Immunol 125:349-356.e13. 2010
    ..However, there are limited data as to whether these beneficial effects are due to enhanced anti-inflammatory actions or whether such combination therapies affect airway remodeling in patients with asthma...
  44. ncbi request reprint The safety of formoterol among patients with asthma using inhaled corticosteroids. Systematic review and meta-analysis
    Roman Jaeschke
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Pol Arch Med Wewn 118:627-35. 2008
    ....
  45. ncbi request reprint Montelukast treatment attenuates the increase in myofibroblasts following low-dose allergen challenge
    Margaret M Kelly
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Chest 130:741-53. 2006
    ..In the present study, we evaluated the effect of montelukast on airway myofibroblasts following low-dose allergen challenge (LDAC)...
  46. ncbi request reprint Effectiveness of early budesonide intervention in Caucasian versus Asian patients with asthma: 3-year results of the START study
    Wan C Tan
    iCAPTURE Centre, UBC, St Paul s Hospital, Vancouver, and Department of Medicine, McMaster University, Hamilton, ON, Canada
    Respirology 11:767-75. 2006
    ..The present analysis compared the efficacy of early intervention with inhaled budesonide in Caucasian and Asian patients over the first 3 years of the inhaled Steroid Treatment As Regular Therapy in early asthma study...
  47. ncbi request reprint IL-10 production in circulating T cells differs between allergen-induced isolated early and dual asthmatic responders
    Koichiro Matsumoto
    Asthma Research Group, St Joseph s Healthcare and McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 109:281-6. 2002
    ..Allergen inhalation by atopic asthmatic subjects results in 2 bronchoconstrictor phenotypes: isolated early response and dual response. Persistence of allergen-induced airway inflammation is a feature of dual responders...
  48. pmc Predictors of loss of asthma control induced by corticosteroid withdrawal
    Jose Belda
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Can Respir J 13:129-33. 2006
    ..Asthma guidelines recommend reducing the dose of inhaled corticosteroids after establishing control...
  49. ncbi request reprint The effects of inhaled budesonide and formoterol in combination and alone when given directly after allergen challenge
    Mylinh Duong
    Firestone Institute for Respiratory Health, St Joseph s Hospital and McMaster University Medical Center, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 119:322-7. 2007
    ..The use of combination inhaled budesonide and formoterol as maintenance and reliever therapy significantly improves the risk and the time to exacerbations in asthma...
  50. ncbi request reprint Effects of an anti-TSLP antibody on allergen-induced asthmatic responses
    Gail M Gauvreau
    From the Firestone Institute of Respiratory Health, Department of Medicine, McMaster University, Hamilton, ON G M G, P M O, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Laval University, Quebec City, QC L P B, Division of Respirology, Critical Care and Sleep Medicine, University of Saskatchewan, Saskatoon, SK D C, B E D, Institute for Heart and Lung Health, University of British Columbia, Vancouver J M F, and Snyder Institute for Chronic Diseases, Faculty of Medicine, Calgary, AB R L all in Canada Amgen, Thousand Oaks, CA Y W, M B, C D, K S G, L S, E B, J R P and Amgen, Seattle J B, M R C
    N Engl J Med 370:2102-10. 2014
    ..AMG 157 is a human anti-TSLP monoclonal immunoglobulin G2λ that binds human TSLP and prevents receptor interaction...
  51. ncbi request reprint Progenitor egress from the bone marrow after allergen challenge: role of stromal cell-derived factor 1alpha and eotaxin
    Sandra C Dorman
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 115:501-7. 2005
    ..CCR3 expression on CD34+ cells mediates migration to eotaxin in vitro. CXCR4 and stromal cell-derived factor (SDF)-1alpha are important for stem cell homing to hemopoietic compartments...
  52. ncbi request reprint The effects of an anti-CD11a mAb, efalizumab, on allergen-induced airway responses and airway inflammation in subjects with atopic asthma
    Gail M Gauvreau
    Department of Medicine, McMaster University, Health Sciences Centre, Hamilton, ON, Canada
    J Allergy Clin Immunol 112:331-8. 2003
    ..Blocking of LFA-1/intercellular adhesion molecule interactions could inhibit asthmatic inflammation by blocking adhesion and activation of LFA-1-positive leukocytes...
  53. pmc Roflumilast attenuates allergen-induced inflammation in mild asthmatic subjects
    Gail M Gauvreau
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Respir Res 12:140. 2011
    ..The objective of this study was to evaluate the effects of roflumilast on bronchoconstriction, airway hyperresponsiveness (AHR), and airway inflammation in mild asthmatic patients undergoing allergen inhalation challenge...
  54. ncbi request reprint Effect of low-dose ciclesonide on allergen-induced responses in subjects with mild allergic asthma
    Gail M Gauvreau
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 116:285-91. 2005
    ..Ciclesonide, a nonhalogenated inhaled corticosteroid being developed for the treatment of persistent asthma, remains inactive until cleaved by esterases in the lung...
  55. ncbi request reprint Role for cysteinyl leukotrienes in allergen-induced change in circulating dendritic cell number in asthma
    Krishnan Parameswaran
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, Department of Medicine, McMaster University, Hamilton, Canada
    J Allergy Clin Immunol 114:73-9. 2004
    ..Dendritic cells are important antigen-presenting cells. After an allergen inhalation, their numbers rapidly decrease in circulation and increase in the airway mucosa...
  56. ncbi request reprint Type 2 cytokines in the pathogenesis of sustained airway dysfunction and airway remodeling in mice
    Richard Leigh
    Firestone Institute for Respiratory Health, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 169:860-7. 2004
    ..Our results confirm that IL-4 and IL-13, but not IL-5, are critical for the development of sustained airway hyperreactivity and airway remodeling after allergen exposure...
  57. ncbi request reprint Morphometric analysis of mouse airways after chronic allergen challenge
    Russ Ellis
    Firestone Institute for Respiratory Health and Department of Medicine, St Joseph s Healthcare and McMaster University, Hamilton, Ontario, Canada
    Lab Invest 83:1285-91. 2003
    ..This morphometric technique provides a valid and objective method to assess structural changes in the airways of mice after chronic allergen exposure...
  58. ncbi request reprint Clinical models to compare the safety and efficacy of inhaled corticosteroids in patients with asthma
    Krishnan Parameswaran
    Asthma Research Group, Firestone Institute of Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario
    Can Respir J 10:27-34. 2003
    ....
  59. ncbi request reprint The effect of cysteinyl leukotrienes on growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjects
    Fausto Braccioni
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare, and the Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 110:96-101. 2002
    ..However, the effect of cysLTs on peripheral blood and bone marrow eosinophil pro-genitor cells in allergic subjects is not known...
  60. ncbi request reprint Immunostimulatory sequences regulate interferon-inducible genes but not allergic airway responses
    Gail M Gauvreau
    McMaster University, Hamilton, ON, Canada
    Am J Respir Crit Care Med 174:15-20. 2006
    ..1018 ISS is a synthetic oligonucleotide containing immunostimulatory CpG motifs. In animal studies, 1018 ISS effectively inhibited Th2-mediated lung inflammation, including eosinophil infiltration, and airway hyperresponsiveness...
  61. ncbi request reprint Different profiles of T-cell IFN-gamma and IL-12 in allergen-induced early and dual responders with asthma
    Makoto Yoshida
    Firestone Institute for Respiratory Heath, Department of Medicine, McMaster University, Health Sciences Center, Ontario, Canada
    J Allergy Clin Immunol 115:1004-9. 2005
    ..Persistence of allergen-induced airway response and inflammation is a distinctive feature of dual responders...
  62. ncbi request reprint Protection by budesonide and fluticasone on allergen-induced airway responses after discontinuation of therapy
    Padmaja Subbarao
    Firestone Institute for Respiratory Health, St Joseph s Hospital and McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 115:745-50. 2005
    ..However, the duration of the protective effects of inhaled steroids after discontinuation of therapy has not been established...
  63. doi request reprint Natural regulatory T cells in isolated early responders compared with dual responders with allergic asthma
    Takashi Kinoshita
    Firestone Institute of Respiratory Health, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada Department of Medicine, Division of Respirology, Neurology and Rheumatology, Kurume University, Fukuoka, Japan
    J Allergy Clin Immunol 133:696-703. 2014
    ..Natural regulatory T (Treg) cells are implicated in the regulation of the inflammatory response in patients with allergic asthma...
  64. doi request reprint Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma
    Gail M Gauvreau
    McMaster University, 1200 Main St West, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 183:1007-14. 2011
    ..Extensive evidence in animal models supports a role for IL-13 in the pathobiology of asthma. IMA-638 and IMA-026 are fully humanized IgG(1) antibodies that bind to different epitopes and neutralize IL-13 bioactivity...
  65. ncbi request reprint Effect of ciclesonide dose and duration of therapy on exercise-induced bronchoconstriction in patients with asthma
    Padmaja Subbarao
    Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Allergy Clin Immunol 117:1008-13. 2006
    ..Inhaled corticosteroid therapy improves exercise symptoms in asthmatic subjects...
  66. ncbi request reprint Cysteinyl leukotrienes promote human airway smooth muscle migration
    Krishnan Parameswaran
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 166:738-42. 2002
    ..The phosphatidylinositol-3 kinase pathway is a key signaling mechanism in the chemotactic migration of ASM cells in response to cysteinyl leukotrienes...
  67. doi request reprint Lung homing of endothelial progenitor cells in humans with asthma after allergen challenge
    Haruki Imaoka
    Asthma Research Group, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 184:771-8. 2011
    ..We have previously shown that inhibiting allergen (Ag)-induced recruitment of EPC in sensitized mice attenuated increased bronchial vascularity and development of airway hyperresponsiveness...
  68. pmc A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure
    Alba Llop-Guevara
    Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Hamilton, Ontario, Canada
    PLoS ONE 9:e88714. 2014
    ....
  69. doi request reprint Modulation of beta1-integrins on hemopoietic progenitor cells after allergen challenge in asthmatic subjects
    Adriana E Catalli
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 122:803-10. 2008
    ..Understanding the mechanisms regulating progenitor cell mobilization and trafficking to the peripheral circulation might be important for the development of effective asthma therapies...
  70. ncbi request reprint Inhaled corticosteroids for asthma: common clinical quandaries
    Krishnan Parameswaran
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Asthma 40:107-18. 2003
    ..However, they do not normalize lung function and prevent structural changes in the airway wall in all asthmatic patients...
  71. ncbi request reprint The safety of long-acting beta-agonists among patients with asthma using inhaled corticosteroids: systematic review and metaanalysis
    Roman Jaeschke
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 178:1009-16. 2008
    ....
  72. ncbi request reprint Acute, but not resolved, influenza A infection enhances susceptibility to house dust mite-induced allergic disease
    Amal A Al-Garawi
    Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Immunol 182:3095-104. 2009
    ..Thus, the proinflammatory environment established during an acute influenza A infection enhances Th2-polarized immunity to a low dose of HDM and precipitates marked lung dysfunction...
  73. doi request reprint Myeloid and plasmacytoid dendritic cells in induced sputum after allergen inhalation in subjects with asthma
    Benny Dua
    Firestone Institute for Respiratory Health, St Joseph s Hospital and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 126:133-9. 2010
    ..In animal models, the induction and maintenance of allergic airway inflammation is primarily a function of myeloid dendritic cells, whereas the tolerization to inhaled allergens is likely a function of plasmacytoid dendritic cells...
  74. pmc Allergen-induced fluctuation in CC chemokine receptor 3 expression on bone marrow CD34+ cells from asthmatic subjects: significance for mobilization of haemopoietic progenitor cells in allergic inflammation
    Roma Sehmi
    Firestone Institute of Respiratory Health, Asthma Research Group, St Joseph s Healthcare, Divisions of Clinical Immunology, McMaster University, Hamilton, Ontario, Canada
    Immunology 109:536-46. 2003
    ....
  75. ncbi request reprint Recent advances in the pathophysiology of asthma
    Desmond M Murphy
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, McMaster University, Hamilton, ON, Canada
    Chest 137:1417-26. 2010
    ..This review examines the newer information on the pathophysiologic characteristics of asthma and focuses on papers published over the past 3 years that have helped to improve current levels of understanding...
  76. doi request reprint Shifting of immune responsiveness to house dust mite by influenza A infection: genomic insights
    Amal Al-Garawi
    Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    J Immunol 188:832-43. 2012
    ..We propose that influenza A infection primes the lung environment in such a way as to lower the threshold of allergen responsiveness, thus facilitating the emergence of a clinically significant allergic phenotype...
  77. ncbi request reprint Asthma management by monitoring sputum neutrophil count
    Shelley Pallan
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, Hamilton, Ontario, Canada
    Chest 134:628-30. 2008
    ....
  78. pmc Ventilation and perfusion lung scintigraphy of allergen-induced airway responses in atopic asthmatic subjects
    Krishnan Parameswaran
    Department of Respiratory Medicine, Sunderland Royal Hospital, Sunderland, UK
    Can Respir J 14:285-91. 2007
    ..Both ventilation (V) and perfusion (Q) of the lungs are altered in asthma, but their relationships with allergen-induced airway responses and gas exchange are not well described...
  79. ncbi request reprint Modulation of human airway smooth muscle migration by lipid mediators and Th-2 cytokines
    Krishnan Parameswaran
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, 50 Charlton Avenue East, Hamilton, ON, L8N 4A6 Canada
    Am J Respir Cell Mol Biol 37:240-7. 2007
    ..IL-13 can promote airway smooth muscle migration through Src-kinase and leukotriene-dependent pathways. This may contribute to the accumulation of smooth muscle cells in remodeled airway submucosa...
  80. ncbi request reprint Changing pattern of sputum cell counts during successive exacerbations of airway disease
    Liesel D'silva
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
    Respir Med 101:2217-20. 2007
    ..We examined changes in the cellular nature of airway inflammation between consecutive exacerbations and their predictors in individual patients...
  81. pmc Altered respiratory physiology in obesity
    Krishnan Parameswaran
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, 50 Charlton Avenue East, Hamilton, Ontario, Canada
    Can Respir J 13:203-10. 2006
    ..Whether obesity contributes to asthma and airway hyper-responsiveness is uncertain. Weight reduction and physical activity are effective means of reversing the respiratory complications of obesity...
  82. ncbi request reprint Airway hyperresponsiveness
    Paul M O'Byrne
    Firestone Institute for Respiratory Health, St Joseph s Hospital, Hamilton, ON, Canada
    Chest 123:411S-6S. 2003
    ..The mechanisms of the transient allergen-induced airway hyperresponsiveness are not likely to fully explain the underlying mechanisms of the persistent airway hyperresponsiveness in asthmatic patients...
  83. pmc Sputum neutrophilia can mask eosinophilic bronchitis during exacerbations
    Christopher J Allen
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Can Respir J 14:281-4. 2007
    ..Exacerbations of airway disease are eosinophilic, neutrophilic, both or neither. The primary objective of the present study was to identify whether the treatment of a neutrophilic bronchitis can unmask an associated eosinophilia...
  84. ncbi request reprint Eosinophilic bronchitis in asthma: a model for establishing dose-response and relative potency of inhaled corticosteroids
    Margaret M Kelly
    Airways Research Group, Firestone Institute for Respiratory Health, Hamilton, Canada
    J Allergy Clin Immunol 117:989-94. 2006
    ..Newer generations and formulations of inhaled corticosteroids have necessitated the development of a clinically relevant model to compare their clinical potency...
  85. pmc In vivo-to-in silico iterations to investigate aeroallergen-host interactions
    Alba Llop-Guevara
    Department of Pathology and Molecular Medicine, Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 3:e2426. 2008
    ....
  86. ncbi request reprint Global guidelines for asthma management: summary of the current status and future challenges
    Paul M O'Byrne
    Firestone Institute for Respiratory Health, St Joseph s Hospital and McMaster University, Hamilton, Ontario, Canada
    Pol Arch Med Wewn 120:511-7. 2010
    ..In an effort to remain current, a yearly update, based on an extensive review of the previous year's peer-reviewed literature on asthma management, is available on the web version of the GINA guidelines...
  87. ncbi request reprint Does the current stepwise approach to asthma pharmacotherapy encourage over-treatment?
    Paul M O'Byrne
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Respirology 15:596-602. 2010
    ....
  88. ncbi request reprint Airway hyperresponsiveness and calcium handling by smooth muscle: a "deeper look"
    Krishnan Parameswaran
    Asthma Research Group, Department of Medicine, St Joseph s Healthcare and McMaster University, Hamilton, ON, Canada
    Chest 121:621-4. 2002
    ..The amplitude, frequency, or localization of Ca(2+) oscillations in the smooth muscle may determine the degree of airway sensitivity and reactivity, which are characteristic features of asthma...
  89. doi request reprint Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis
    Antje Moeller
    Department of Medicine, McMaster University, and Firestone Institute for Respiratory Health, St Joseph s Healthcare, Hamilton, ON, L8N 4A6 Canada
    Am J Respir Crit Care Med 179:588-94. 2009
    ..Fibrocytes are circulating mesenchymal cell progenitors that are involved in tissue repair and fibrosis...
  90. ncbi request reprint Liver X receptor stimulates cholesterol efflux and inhibits expression of proinflammatory mediators in human airway smooth muscle cells
    Christopher J Delvecchio
    Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
    Mol Endocrinol 21:1324-34. 2007
    ..Our findings reveal biological roles for LXR in ASM cells and suggest that modulation of LXR activity offers prospects for new therapeutic approaches in the treatment of asthma and other inflammatory respiratory diseases...
  91. ncbi request reprint Role of extracellular matrix and its regulators in human airway smooth muscle biology
    Krishnan Parameswaran
    Firestone Institute for Respiratory Health, McMaster University and St Joseph s Healthcare, Hamilton, Ontario, Canada
    Cell Biochem Biophys 44:139-46. 2006
    ..Thus, the intertwined relationship of ASM and ECM and their response to stimuli such as chronic inflammation in diseases such as asthma and COPD contribute to the remodeling seen in airways of patients with these diseases...