Lennard P Niles

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. pmc Neural stem cells express melatonin receptors and neurotrophic factors: colocalization of the MT1 receptor with neuronal and glial markers
    Lennard P Niles
    Department of Psychiatry and Behavioural Neurosciences, McMaster University 1200 Main Street West, Hamilton ON L8N 3Z5, Canada
    BMC Neurosci 5:41. 2004
  2. doi request reprint Melatonin induces histone hyperacetylation in the rat brain
    Lennard P Niles
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, HSC 4N77, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Neurosci Lett 541:49-53. 2013
  3. doi request reprint Valproic acid up-regulates melatonin MT1 and MT2 receptors and neurotrophic factors CDNF and MANF in the rat brain
    Lennard P Niles
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Int J Neuropsychopharmacol 15:1343-50. 2012
  4. doi request reprint Epigenetic targets for melatonin: induction of histone H3 hyperacetylation and gene expression in C17.2 neural stem cells
    Rohita Sharma
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Pineal Res 45:277-84. 2008
  5. ncbi request reprint Modulation of tyrosine hydroxylase expression by melatonin in human SH-SY5Y neuroblastoma cells
    Catherine R McMillan
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, HSC 4N77, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Neurosci Lett 419:202-6. 2007
  6. doi request reprint Clinically relevant concentrations of valproic acid modulate melatonin MT(1) receptor, HDAC and MeCP2 mRNA expression in C6 glioma cells
    Bora Kim
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, HSC 4N77, Hamilton, ON, Canada
    Eur J Pharmacol 589:45-8. 2008
  7. ncbi request reprint Human melatonin MT1 receptor induction by valproic acid and its effects in combination with melatonin on MCF-7 breast cancer cell proliferation
    Sana Jawed
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, HSC 4N77, 1200 Main Street West, Hamilton, Canada ON L8N 3Z5
    Eur J Pharmacol 560:17-22. 2007
  8. doi request reprint HDAC inhibitor M344 suppresses MCF-7 breast cancer cell proliferation
    Angie Yeung
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    Biomed Pharmacother 66:232-6. 2012
  9. ncbi request reprint Physiological neuroprotection by melatonin in a 6-hydroxydopamine model of Parkinson's disease
    Rohita Sharma
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Brain Res 1068:230-6. 2006
  10. ncbi request reprint Neural stem cell transplantation and melatonin treatment in a 6-hydroxydopamine model of Parkinson's disease
    Rohita Sharma
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Pineal Res 43:245-54. 2007

Collaborators

  • Gregory M Brown
  • Laurie C Doering
  • Rohita Sharma
  • Catherine R McMillan
  • Bora Kim
  • Sana Jawed
  • Lyda M Rincón Castro
  • Angie Yeung
  • Thomas Ottenhof
  • Kristen J Armstrong
  • Ayush Lacoul
  • Sarra Bahna
  • Rishi K Bhargava
  • Raphael Ahn
  • Na Hyea Kang
  • Paulina A Rzeczkowska
  • Eva S Werstiuk
  • Tom Ottenhof
  • Catherine C Tenn
  • Michel Gallant

Detail Information

Publications12

  1. pmc Neural stem cells express melatonin receptors and neurotrophic factors: colocalization of the MT1 receptor with neuronal and glial markers
    Lennard P Niles
    Department of Psychiatry and Behavioural Neurosciences, McMaster University 1200 Main Street West, Hamilton ON L8N 3Z5, Canada
    BMC Neurosci 5:41. 2004
    ..In view of recent evidence suggesting a role for the pineal hormone melatonin in vertebrate development, it was also of interest to determine whether its G protein-coupled MT1 and MT2 receptors are expressed in NSCs...
  2. doi request reprint Melatonin induces histone hyperacetylation in the rat brain
    Lennard P Niles
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, HSC 4N77, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Neurosci Lett 541:49-53. 2013
    ..These findings suggest that chromatin remodeling and associated changes in the epigenetic regulation of gene expression underlie the multiple physiological effects of melatonin...
  3. doi request reprint Valproic acid up-regulates melatonin MT1 and MT2 receptors and neurotrophic factors CDNF and MANF in the rat brain
    Lennard P Niles
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Int J Neuropsychopharmacol 15:1343-50. 2012
    ..The robust multi-fold induction of MT1 and MT2 receptors in the hippocampus suggests a role for the melatonergic system in the psychotropic effects of VPA...
  4. doi request reprint Epigenetic targets for melatonin: induction of histone H3 hyperacetylation and gene expression in C17.2 neural stem cells
    Rohita Sharma
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Pineal Res 45:277-84. 2008
    ..These findings suggest novel roles for melatonin in stem cell differentiation and epigenetic modulation of gene transcription...
  5. ncbi request reprint Modulation of tyrosine hydroxylase expression by melatonin in human SH-SY5Y neuroblastoma cells
    Catherine R McMillan
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, HSC 4N77, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Neurosci Lett 419:202-6. 2007
    ..These findings suggest a physiological role for melatonin in modulating TH expression, possibly via the MT(1) receptor...
  6. doi request reprint Clinically relevant concentrations of valproic acid modulate melatonin MT(1) receptor, HDAC and MeCP2 mRNA expression in C6 glioma cells
    Bora Kim
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, HSC 4N77, Hamilton, ON, Canada
    Eur J Pharmacol 589:45-8. 2008
    ..The ability of clinical concentrations of valproic acid to significantly alter melatonin MT(1) receptor expression, suggests a role for this receptor in the diverse neuropharmacological and oncostatic effects of this agent...
  7. ncbi request reprint Human melatonin MT1 receptor induction by valproic acid and its effects in combination with melatonin on MCF-7 breast cancer cell proliferation
    Sana Jawed
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, HSC 4N77, 1200 Main Street West, Hamilton, Canada ON L8N 3Z5
    Eur J Pharmacol 560:17-22. 2007
    ..Moreover, the enhanced antiproliferative effect observed with a combination of valproic acid and melatonin suggests that a similar therapeutic approach may be beneficial in breast cancer...
  8. doi request reprint HDAC inhibitor M344 suppresses MCF-7 breast cancer cell proliferation
    Angie Yeung
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    Biomed Pharmacother 66:232-6. 2012
    ..The results of this study reinforce previous findings indicating that HDAC inhibitors are an important group of oncostatic drugs, and show that M344 is a potent suppressor of breast cancer cell proliferation...
  9. ncbi request reprint Physiological neuroprotection by melatonin in a 6-hydroxydopamine model of Parkinson's disease
    Rohita Sharma
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Brain Res 1068:230-6. 2006
    ..These findings support a physiological role for melatonin in protecting against parkinsonian neurodegeneration in the nigrostriatal system...
  10. ncbi request reprint Neural stem cell transplantation and melatonin treatment in a 6-hydroxydopamine model of Parkinson's disease
    Rohita Sharma
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Pineal Res 43:245-54. 2007
    ..These findings suggest that stem cell therapy and concomitant use of neuroprotective agents such as melatonin could be a viable approach in Parkinson's disease...
  11. ncbi request reprint Novel targets for valproic acid: up-regulation of melatonin receptors and neurotrophic factors in C6 glioma cells
    Lyda M Rincón Castro
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Neurochem 95:1227-36. 2005
    ..Moreover, the foregoing suggests that combinations of VPA and melatonin could provide novel therapeutic strategies in neurological and psychiatric disorders...
  12. ncbi request reprint Induction of GDNF mRNA expression by melatonin in rat C6 glioma cells
    Kristen J Armstrong
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada
    Neuroreport 13:473-5. 2002
    ..Given the potency of GDNF in maintaining nigrostriatal dopaminergic integrity, understanding the mechanisms of its induction by melatonin could provide novel therapies for Parkinson's disease...