Madhu K Natarajan

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. pmc The risks of waiting for cardiac catheterization: a prospective study
    Madhu K Natarajan
    Division of Cardiology, Population Health Research Institute, McMaster University, Hamilton, Ont
    CMAJ 167:1233-40. 2002
  2. pmc Primary angioplasty for ST-segment elevation myocardial infarction: ready for prime time?
    Madhu K Natarajan
    Division of Cardiology, Department of Medicine, and the Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ont
    CMAJ 169:32-5. 2003
  3. ncbi request reprint Incidence, predictors, and clinical significance of troponin-I elevation without creatine kinase elevation following percutaneous coronary interventions
    Madhu K Natarajan
    Division of Cardiology, Department of Medicine, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Am J Cardiol 93:750-3. 2004
  4. ncbi request reprint A randomized pilot study of dalteparin versus unfractionated heparin during percutaneous coronary interventions
    Madhu K Natarajan
    Division of Cardiology, Department of Medicine, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Am Heart J 151:175. 2006
  5. pmc Determining optimal population rates of cardiac catheterization: a phantom alternative?
    Madhu K Natarajan
    Population Health Research Institute and Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ont
    CMAJ 173:49-52. 2005
  6. doi request reprint Safety and feasibility of early hospital discharge in ST-segment elevation myocardial infarction--a prospective and randomized trial in low-risk primary percutaneous coronary intervention patients (the Safe-Depart Trial)
    Mark A Kotowycz
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Am Heart J 159:117.e1-6. 2010
  7. doi request reprint Predictors of normal coronary arteries at coronary angiography
    Kevin Levitt
    University of Toronto, Toronto, Ontario, Canada
    Am Heart J 166:694-700. 2013
  8. doi request reprint Effect of radial versus femoral access on radiation dose and the importance of procedural volume: a substudy of the multicenter randomized RIVAL trial
    Sanjit S Jolly
    Department of Medicine, McMaster University and Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
    JACC Cardiovasc Interv 6:258-66. 2013
  9. pmc Long-term outcomes with paclitaxel-eluting stents versus bare metal stents in everyday practice: a Canadian experience
    Jon David R Schwalm
    McMaster University Hamilton Health Sciences, Hamilton, Ontario, Canada
    Can J Cardiol 26:e40-4. 2010
  10. ncbi request reprint Warfarin after anterior myocardial infarction in current era of dual antiplatelet therapy: a randomized feasibility trial
    Jon David R Schwalm
    Department of Medicine, Division of Cardiology, Hamilton Health Sciences and McMaster University, 5th Floor, McMaster Clinic, 237 Barton Street East, Hamilton, ON L8L 2X2, Canada
    J Thromb Thrombolysis 30:127-32. 2010

Detail Information

Publications39

  1. pmc The risks of waiting for cardiac catheterization: a prospective study
    Madhu K Natarajan
    Division of Cardiology, Population Health Research Institute, McMaster University, Hamilton, Ont
    CMAJ 167:1233-40. 2002
    ..A secondary objective was to identify predictors of cardiac events that occur while patients are waiting...
  2. pmc Primary angioplasty for ST-segment elevation myocardial infarction: ready for prime time?
    Madhu K Natarajan
    Division of Cardiology, Department of Medicine, and the Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ont
    CMAJ 169:32-5. 2003
  3. ncbi request reprint Incidence, predictors, and clinical significance of troponin-I elevation without creatine kinase elevation following percutaneous coronary interventions
    Madhu K Natarajan
    Division of Cardiology, Department of Medicine, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Am J Cardiol 93:750-3. 2004
    ....
  4. ncbi request reprint A randomized pilot study of dalteparin versus unfractionated heparin during percutaneous coronary interventions
    Madhu K Natarajan
    Division of Cardiology, Department of Medicine, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Am Heart J 151:175. 2006
    ..This study examined the relative effects of dalteparin and UFH on coagulation and angiographic and clinical indices during PCI...
  5. pmc Determining optimal population rates of cardiac catheterization: a phantom alternative?
    Madhu K Natarajan
    Population Health Research Institute and Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ont
    CMAJ 173:49-52. 2005
  6. doi request reprint Safety and feasibility of early hospital discharge in ST-segment elevation myocardial infarction--a prospective and randomized trial in low-risk primary percutaneous coronary intervention patients (the Safe-Depart Trial)
    Mark A Kotowycz
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Am Heart J 159:117.e1-6. 2010
    ..Previous studies have shown that many low-risk patients remain in hospital significantly longer...
  7. doi request reprint Predictors of normal coronary arteries at coronary angiography
    Kevin Levitt
    University of Toronto, Toronto, Ontario, Canada
    Am Heart J 166:694-700. 2013
    ..However, little is known about the clinical predictors of normal angiograms and whether this rate varies across different cardiac centers in Ontario...
  8. doi request reprint Effect of radial versus femoral access on radiation dose and the importance of procedural volume: a substudy of the multicenter randomized RIVAL trial
    Sanjit S Jolly
    Department of Medicine, McMaster University and Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
    JACC Cardiovasc Interv 6:258-66. 2013
    ..The authors sought to compare the radiation dose between radial and femoral access...
  9. pmc Long-term outcomes with paclitaxel-eluting stents versus bare metal stents in everyday practice: a Canadian experience
    Jon David R Schwalm
    McMaster University Hamilton Health Sciences, Hamilton, Ontario, Canada
    Can J Cardiol 26:e40-4. 2010
    ..However, recent reports suggest there may be an increase in late stent thrombosis with long-term follow-up in PES-treated patients...
  10. ncbi request reprint Warfarin after anterior myocardial infarction in current era of dual antiplatelet therapy: a randomized feasibility trial
    Jon David R Schwalm
    Department of Medicine, Division of Cardiology, Hamilton Health Sciences and McMaster University, 5th Floor, McMaster Clinic, 237 Barton Street East, Hamilton, ON L8L 2X2, Canada
    J Thromb Thrombolysis 30:127-32. 2010
    ..The purpose of this study is to assess the feasibility of evaluating the added benefit and safety of triple therapy (TT-warfarin, ASA, and clopidogrel) versus dual therapy (DT-ASA and clopidogrel) in patients at risk of LVT post aSTEMI...
  11. doi request reprint Radial artery versus femoral artery access options in coronary angiogram procedures: randomized controlled trial of a patient-decision aid
    Jon David Schwalm
    McMaster University Hamilton Health Sciences, Department of Medicine, Division of Cardiology, Population Health Research Institute, Canada
    Circ Cardiovasc Qual Outcomes 5:260-6. 2012
    ..The purpose of this trial was to evaluate the effectiveness of an evidence-based PtDA compared with usual care in patients eligible for radial and femoral artery access...
  12. doi request reprint Randomized trial of insulin versus usual care in reducing restenosis after coronary intervention in patients with diabetes. the STent Restenosis And Metabolism (STREAM) study
    Madhu K Natarajan
    Division of Cardiology, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Cardiovasc Revasc Med 13:95-100. 2012
    ..The objective of this study was to determine whether insulin-mediated glucose lowering reduces in-stent restenosis in patients with diabetes undergoing PCIs...
  13. doi request reprint Insight into capacity planning for cardiac catheterization services: policy lessons learned from "Looking in the Mirror" over a decade
    Mat Mercuri
    Heart Investigation Unit, Hamilton Health Sciences, 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada
    Health Policy 91:314-20. 2009
    ..The purpose of this study is to describe our experience over the past decade in attempting to meet RMWTs for patients needing CATH at our centre, and to discuss issues concerning capacity planning in providing timely service...
  14. doi request reprint Mortality and morbidity following a major bleed in a registry population with acute ST elevation myocardial infarction
    Shoaib Amlani
    Department of Medicine, McMaster University, 237 Barton Street East, Hamilton, ON L8L 2X2, Canada
    J Thromb Thrombolysis 30:434-40. 2010
    ..Therapies that maintain efficacy while reducing bleeding and that reduce the risk of death in patients who develop bleeding are needed...
  15. doi request reprint Radial artery access as a predictor of increased radiation exposure during a diagnostic cardiac catheterization procedure
    Mathew Mercuri
    Heart Investigation Unit, Hamilton Health Sciences, Ontario, Canada
    JACC Cardiovasc Interv 4:347-52. 2011
    ....
  16. ncbi request reprint Primary and rescue percutaneous coronary intervention with paclitaxel-eluting stent implantation in ST-elevation myocardial infarction
    Jon David Reid Schwalm
    The Department of Medicine, Division of Cardiology, Hamilton General Hospital Site, McMaster University, Hamilton, Ontario, Canada
    Am J Cardiol 97:1308-10. 2006
    ..PES implantation appears to be safe and possibly superior to BMS implantation in terms of 1-year major cardiovascular outcomes in the setting of ST-elevation myocardial infarction...
  17. ncbi request reprint Randomized, blinded trial comparing fondaparinux with unfractionated heparin in patients undergoing contemporary percutaneous coronary intervention: Arixtra Study in Percutaneous Coronary Intervention: a Randomized Evaluation (ASPIRE) Pilot Trial
    Shamir R Mehta
    McMaster University and the Population Health Research Institute, Hamilton Health Sciences, General Division, 237 Barton St E, Hamilton, Ontario, Canada L6K 1B8
    Circulation 111:1390-7. 2005
    ..We performed a randomized trial to determine the safety and feasibility of fondaparinux in the percutaneous coronary intervention (PCI) setting...
  18. pmc Effect of operator and institutional volume on clinical outcomes after percutaneous coronary interventions performed in Canada and the United States: a brief report from the Enhanced Suppression of the Platelet glycoprotein IIb/IIIa Receptor with Integril
    Mina Madan
    Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Can J Cardiol 25:e269-72. 2009
    ..It was previously reported that Canadian patients had reduced rates of 30-day and one-year death, myocardial infarction (MI) or target vessel revascularization (TVR) compared with patients in the United States (US)...
  19. doi request reprint Early versus delayed invasive intervention in acute coronary syndromes
    Shamir R Mehta
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 360:2165-75. 2009
    ..Earlier trials have shown that a routine invasive strategy improves outcomes in patients with acute coronary syndromes without ST-segment elevation. However, the optimal timing of such intervention remains uncertain...
  20. ncbi request reprint Radial versus femoral access for emergent percutaneous coronary intervention with adjunct glycoprotein IIb/IIIa inhibition in acute myocardial infarction--the RADIAL-AMI pilot randomized trial
    Warren J Cantor
    St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 150:543-9. 2005
    ..Limited data exist for radial access in acute myocardial infarction, where reperfusion must occur quickly...
  21. pmc Comparison of one-year clinical outcomes with paclitaxel-eluting stents versus bare metal stents in everyday practice
    Mayraj Ahmad
    Department of Medicine, McMaster University, Hamilton, Canada
    Can J Cardiol 24:771-5. 2008
    ..However, the effectiveness of PES in patients treated during routine practice has not been fully established...
  22. pmc Can we improve length of hospitalization in ST elevation myocardial infarction patients treated with primary percutaneous coronary intervention?
    Mark A Kotowycz
    Hamilton Health Sciences, Hamilton, Canada
    Can J Cardiol 25:585-8. 2009
    ..The Zwolle primary percutaneous coronary intervention (PCI) index is an externally validated risk score that has been used to identify low-risk primary PCI patients who can safely be discharged from the hospital within 48 h to 72 h...
  23. pmc Delayed educational reminders for long-term medication adherence in ST-elevation myocardial infarction (DERLA-STEMI): protocol for a pragmatic, cluster-randomized controlled trial
    Noah M Ivers
    Family Practice Health Centre, Women s College Research Institute, Women s College Hospital, 76 Grenville Ave Toronto, Toronto, Ontario, Canada
    Implement Sci 7:54. 2012
    ..Discontinuation of cardiac medications in such patients is associated with increased mortality...
  24. pmc Optimal method of coronary revascularization in patients receiving dialysis: systematic review
    Immaculate F Nevis
    Division of Nephrology, University of Western Ontario, London, Ontario, Canada
    Clin J Am Soc Nephrol 4:369-78. 2009
    ..Patients receiving dialysis have a high burden of cardiovascular disease. Some receive coronary artery revascularization but the optimal method is controversial...
  25. ncbi request reprint Improving the timeliness of care for patients with acute ST-elevation myocardial infarction: implications of "self-transport" versus use of EMS
    Mathew Mercuri
    Heart Investigation Unit, Hamilton Health Sciences, Hamilton, Ontario
    Healthc Q 13:105-9. 2010
    ..Healthcare providers are challenged with both implementing strategies for improving care (minimizing delays to reperfusion) for patients not using EMS, and encouraging patients to access care via EMS in the event of acute chest pain...
  26. ncbi request reprint The relationship of body mass index to outcomes after percutaneous coronary intervention
    Mamdouh M Shubair
    Department of Medicine, McMaster University, Hamilton Health Sciences General Site, Hamilton, Ontario, Canada
    J Interv Cardiol 19:388-95. 2006
    ..To evaluate the effect of body mass index (BMI) on in-hospital outcomes in patients undergoing percutaneous coronary intervention (PCI) at a tertiary care hospital center in Ontario, Canada...
  27. ncbi request reprint An international survey of clinical practice during primary percutaneous coronary intervention for ST-elevation myocardial infarction with a focus on aspiration thrombectomy
    Juan J Russo
    University of Toronto, Toronto, Ontario, Canada
    EuroIntervention 8:1143-8. 2013
    ..We sought to evaluate practices during PPCI for ST-elevation myocardial infarction (STEMI), including the use of aspiration thrombectomy, and to determine the feasibility of conducting a definitive aspiration thrombectomy trial...
  28. doi request reprint Assessing the association of appropriateness of coronary revascularization and clinical outcomes for patients with stable coronary artery disease
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Am Coll Cardiol 60:1876-84. 2012
    ..The study assessed the appropriateness of coronary revascularization in Ontario, Canada, and examined its association with longer-term outcomes...
  29. doi request reprint An even smaller area variation: differing practice patterns among interventional cardiologists within a single high volume tertiary cardiac centre
    Mathew Mercuri
    Heart Investigation Unit, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Health Policy 104:179-85. 2012
    ..Variations in the rate of use of common medical procedures/therapies are widely documented. Previous studies tend to focus on variations between either hospitals or geographic areas. Few studies examine within centre practice variations...
  30. ncbi request reprint Predictors of increased radiation dose during percutaneous coronary intervention
    Mathew Mercuri
    Heart Investigation Unit, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Am J Cardiol 104:1241-4. 2009
    ..In revealing a priori known factors associated with an increased radiation dose during PCI, physicians and patients might be more able to evaluate the risks and benefits of such a procedure...
  31. pmc Impact of clinical urgency, physician supply and procedural capacity on regional variations in wait times for coronary angiography
    Harindra C Wijeysundera
    Sunnybrook Health Sciences Center, 2075 Bayview Avenue, Toronto, Ontario, Canada
    BMC Health Serv Res 10:5. 2010
    ..Our objective was to evaluate the extent to which demand-side factors such as clinical urgency/need, and supply-side factors, as reflected by differences in physician and procedural supply account for these inequalities...
  32. ncbi request reprint A comparison of clinical outcomes between Canadian and American patients after nonurgent coronary stenting
    Mina Madan
    Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Can J Cardiol 20:1343-9. 2004
    ..Few data are available comparing PCI outcomes between the two countries in the era of coronary stenting and adjunctive glycoprotein IIb/IIIa inhibition...
  33. doi request reprint Prevalence of bruising at the vascular access site one week after elective cardiac catheterisation or percutaneous coronary intervention
    Tammy L Cosman
    Peri Operative Cardiovascular Service, Surgical Oncology and Orthopedics Program, Hamilton Health Sciences, Hamilton, ON, Canada
    J Clin Nurs 20:1349-56. 2011
    ..To identify the prevalence and predictors of VAS bruising in the 5-7 days following cardiac catheterisation or percutaneous coronary intervention...
  34. ncbi request reprint Pre-procedural plasma levels of C-reactive protein and interleukin-6 do not predict late coronary angiographic restenosis after elective stenting
    Amit Segev
    The Roy and Ann Foss Cardiovascular Research Program, Terrence Donnelly Heart Center, Division of Cardiology, St Michael s Hospital, 7CC 008, 30 Bond Street, University of Toronto, Toronto, Ont, Canada
    Eur Heart J 25:1029-35. 2004
    ..In patients with stable angina pectoris,we examined whether baseline CRP and IL-6 predict late coronary angiographic restenosis after stenting...
  35. doi request reprint Canadian cardiovascular society position statement on radiation exposure from cardiac imaging and interventional procedures
    Madhu K Natarajan
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada Electronic address
    Can J Cardiol 29:1361-8. 2013
    ..The purpose of this document is to inform health care providers on the key concepts related to radiation risk from common cardiac procedures and provide specific recommendations on ensuring quality of care. ..
  36. ncbi request reprint Impact of routine in-hospital assessment of low-density lipoprotein levels and standardized orders on statin therapy in patients undergoing percutaneous coronary interventions
    Mayraj Ahmad
    Department of Medicine, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    J Invasive Cardiol 17:518-20. 2005
    ..We evaluated the impact of the implementation of routine cholesterol profile measurements and standardized orders post-PCI on the number of patients receiving statin therapy...
  37. ncbi request reprint Cardiac Angiography in Renally Impaired Patients (CARE) study: a randomized double-blind trial of contrast-induced nephropathy in patients with chronic kidney disease
    Richard J Solomon
    Department of Renal Services, Fletcher Allen Health Care, University of Vermont, Burlington, VT 05401, USA
    Circulation 115:3189-96. 2007
    ..No direct comparisons exist of the renal tolerability of the low-osmolality contrast medium iopamidol with that of the iso-osmolality contrast medium iodixanol in high-risk patients...
  38. ncbi request reprint Radiation dose in interventional cardiology procedures: urgent need for monitoring dose and establishing diagnostic reference levels
    Mat Mercuri
    Heart Investigation Unit at Hamilton Health Sciences HHS, Ontario
    Healthc Q 11:76-83. 2008
    ..As a subsequent focus, this article presents the process for setting benchmarks for optimizing administered dose in the Hamilton Health Sciences Heart Investigation Unit...
  39. ncbi request reprint Low rates of angiographic and clinical restenosis with the new flexible MedStent for the treatment of single discrete coronary lesions
    Amit Segev
    Roy and Ann Foss Cardiovascular Research Program, Terrence Donnelly Heart Center, St Michael s Hospital, Toronto, Ontario
    J Interv Cardiol 17:167-70. 2004
    ..0% (95% CI, 12.5%-27.5%). The results of the Medstent study in discrete, de novo native coronary lesions demonstrated low incidence of clinical events as well as favorable angiographic restenosis rate...