Parameswaran Nair

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. pmc Reproducibility, validity, and responsiveness of cell counts in blown nasal secretions
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Allergy Rhinol (Providence) 2:3-5. 2011
  2. pmc Update on clinical inflammometry for the management of airway diseases
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare Hamilton, Ontario
    Can Respir J 20:117-20. 2013
  3. ncbi request reprint How to diagnose and phenotype asthma
    Parameswaran Nair
    Department of Medicine, St Joseph s Healthcare, McMaster University, 50 Charlton Avenue East, Hamilton, Ontario L8N4A6, Canada
    Clin Chest Med 33:445-57. 2012
  4. doi request reprint Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial
    P Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin Exp Allergy 42:1097-103. 2012
  5. ncbi request reprint Modulation of human airway smooth muscle migration by lipid mediators and Th-2 cytokines
    Krishnan Parameswaran
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, 50 Charlton Avenue East, Hamilton, ON, L8N 4A6 Canada
    Am J Respir Cell Mol Biol 37:240-7. 2007
  6. pmc Ventilation and perfusion lung scintigraphy of allergen-induced airway responses in atopic asthmatic subjects
    Krishnan Parameswaran
    Department of Respiratory Medicine, Sunderland Royal Hospital, Sunderland, UK
    Can Respir J 14:285-91. 2007
  7. doi request reprint The effects of leptin on airway smooth muscle responses
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, Hamilton, Ontario, Canada
    Am J Respir Cell Mol Biol 39:475-81. 2008
  8. ncbi request reprint Does early intervention with inhaled corticosteroids alter the natural history of mild persistent asthma?
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, Hamilton, ON, Canada
    Pol Arch Med Wewn 118:441-4. 2008
  9. pmc The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St, Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Allergy Asthma Clin Immunol 7:4. 2011
  10. doi request reprint Early interventions with inhaled corticosteroids in asthma: benefits and risks
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Curr Opin Pulm Med 17:12-5. 2011

Collaborators

Detail Information

Publications58

  1. pmc Reproducibility, validity, and responsiveness of cell counts in blown nasal secretions
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Allergy Rhinol (Providence) 2:3-5. 2011
    ..The cell counts are responsive to treatment and can help identify allergic and infective rhinosinusitis and guide therapy and are easy to implement in routine clinical practice...
  2. pmc Update on clinical inflammometry for the management of airway diseases
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare Hamilton, Ontario
    Can Respir J 20:117-20. 2013
    ..Thus, it is unfortunate that this is not used more widely in the management of airway diseases, particularly in patients with severe asthma and chronic obstructive pulmonary disease who experience frequent exacerbations...
  3. ncbi request reprint How to diagnose and phenotype asthma
    Parameswaran Nair
    Department of Medicine, St Joseph s Healthcare, McMaster University, 50 Charlton Avenue East, Hamilton, Ontario L8N4A6, Canada
    Clin Chest Med 33:445-57. 2012
    ....
  4. doi request reprint Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial
    P Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin Exp Allergy 42:1097-103. 2012
    ..It is not clear if they contribute to the lack of control and severity. There are currently no strategies to investigate this by decreasing neutrophil numbers in the airways...
  5. ncbi request reprint Modulation of human airway smooth muscle migration by lipid mediators and Th-2 cytokines
    Krishnan Parameswaran
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, 50 Charlton Avenue East, Hamilton, ON, L8N 4A6 Canada
    Am J Respir Cell Mol Biol 37:240-7. 2007
    ..IL-13 can promote airway smooth muscle migration through Src-kinase and leukotriene-dependent pathways. This may contribute to the accumulation of smooth muscle cells in remodeled airway submucosa...
  6. pmc Ventilation and perfusion lung scintigraphy of allergen-induced airway responses in atopic asthmatic subjects
    Krishnan Parameswaran
    Department of Respiratory Medicine, Sunderland Royal Hospital, Sunderland, UK
    Can Respir J 14:285-91. 2007
    ..Both ventilation (V) and perfusion (Q) of the lungs are altered in asthma, but their relationships with allergen-induced airway responses and gas exchange are not well described...
  7. doi request reprint The effects of leptin on airway smooth muscle responses
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, Hamilton, Ontario, Canada
    Am J Respir Cell Mol Biol 39:475-81. 2008
    ..This is partly mediated by PGE(2) secretion from smooth muscle cells induced by leptin. The association between obesity and asthma is unlikely to be due to a direct effect of leptin on airway smooth muscle...
  8. ncbi request reprint Does early intervention with inhaled corticosteroids alter the natural history of mild persistent asthma?
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, Hamilton, ON, Canada
    Pol Arch Med Wewn 118:441-4. 2008
    ....
  9. pmc The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St, Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Allergy Asthma Clin Immunol 7:4. 2011
    ....
  10. doi request reprint Early interventions with inhaled corticosteroids in asthma: benefits and risks
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Curr Opin Pulm Med 17:12-5. 2011
    ..intermittent therapy based on the Improving Asthma Control Trial (IMPACT)...
  11. ncbi request reprint Clinical equivalence testing of inhaled bronchodilators
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Pol Arch Med Wewn 119:731-5. 2009
    ..RP studies using adequate methodology are necessary to compare long-acting bronchodilators and both short- and long-acting bronchodilators in patients who are also on inhaled corticosteroids...
  12. pmc Altered respiratory physiology in obesity
    Krishnan Parameswaran
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, 50 Charlton Avenue East, Hamilton, Ontario, Canada
    Can Respir J 13:203-10. 2006
    ..Whether obesity contributes to asthma and airway hyper-responsiveness is uncertain. Weight reduction and physical activity are effective means of reversing the respiratory complications of obesity...
  13. ncbi request reprint Measuring bronchitis in airway diseases: clinical implementation and application: Airway hyperresponsiveness in asthma: its measurement and clinical significance
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, Department of Medicine, McMaster University, Hamilton, ON, Canada
    Chest 138:38S-43S. 2010
    ..The clinical usefulness of measurements in exhaled breath condensate has not yet been established...
  14. ncbi request reprint Inhaled corticosteroids for asthma: common clinical quandaries
    Krishnan Parameswaran
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Asthma 40:107-18. 2003
    ..However, they do not normalize lung function and prevent structural changes in the airway wall in all asthmatic patients...
  15. ncbi request reprint Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, ON, Canada
    N Engl J Med 360:985-93. 2009
    ..Secondary objectives were to examine its effect on the number of eosinophils in sputum and blood, symptoms, and airflow limitation...
  16. ncbi request reprint Addition of intravenous aminophylline to beta2 -agonist in adults with acute asthma
    Stephen Emond
    Stanford Kaiser Emergency Medicine Residency Program, Kaiser Permanente Santa Clara Medical Center, Santa Clara, CA 95051, USA
    Ann Emerg Med 40:350-2. 2002
  17. pmc Heterogeneity of bronchitis in airway diseases in tertiary care clinical practice
    Liesel D'silva
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario
    Can Respir J 18:144-8. 2011
    ..The prevalence of different subtypes of bronchitis in routine clinical practice, however, has not been reported...
  18. ncbi request reprint The safety of formoterol among patients with asthma using inhaled corticosteroids. Systematic review and meta-analysis
    Roman Jaeschke
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Pol Arch Med Wewn 118:627-35. 2008
    ....
  19. ncbi request reprint When are biomarkers useful in the management of airway diseases?
    Angira Dasgupta
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Pol Arch Med Wewn 123:183-8. 2013
    ....
  20. pmc Persistent sputum cellularity and neutrophils may predict bronchiectasis
    Nicole Drost
    Division of Respirology, St Joseph s Healthcare, Ontario, Canada
    Can Respir J 18:221-4. 2011
    ..Quantitative cell counts in sputum provide an accurate assessment of the type and severity of bronchitis...
  21. pmc Association between proximity to major roads and sputum cell counts
    Julie Wallace
    Centre for Spatial Analysis, School of Geography and Earth Sciences, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario
    Can Respir J 18:13-8. 2011
    ..Air pollution caused by motor vehicle emissions has been associated with exacerbations of obstructive airway diseases; however, the nature of the resulting bronchitis has not been quantified...
  22. doi request reprint PPAR ligands decrease human airway smooth muscle cell migration and extracellular matrix synthesis
    Jancy Stephen
    Firestone Institure for Respiratory Health, St Joseph s Healthcare, Dept of Medicine, McMaster University, Hamilton, Ontario, Canada
    Eur Respir J 41:425-32. 2013
    ..We conclude that PPAR ligands decrease HASM migration and matrix production and are, therefore, potentially useful for modulating airway remodelling...
  23. pmc Predictors of loss of asthma control induced by corticosteroid withdrawal
    Jose Belda
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Can Respir J 13:129-33. 2006
    ..Asthma guidelines recommend reducing the dose of inhaled corticosteroids after establishing control...
  24. ncbi request reprint Sample sizes for clinical trials using sputum eosinophils as a primary outcome
    Angira Dasgupta
    St Joseph s Healthcare and McMaster University, Hamilton, ON
    Eur Respir J 42:1003-11. 2013
    ..Assuming a minimal clinically important reduction of 15% in absolute terms, 18 subjects in each arm will be required to achieve 80% power using an ANCOVA analysis, which we recommend, to detect significance with an alpha error of 0.05. ..
  25. doi request reprint Antiinflammatory effects of long-acting beta2-agonists in patients with asthma: a systematic review and metaanalysis
    Anees Sindi
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, Hamilton, ON, Canada L8N 4A6
    Chest 136:145-54. 2009
    ....
  26. ncbi request reprint Asthma management by monitoring sputum neutrophil count
    Shelley Pallan
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, Hamilton, Ontario, Canada
    Chest 134:628-30. 2008
    ....
  27. ncbi request reprint The safety of long-acting beta-agonists among patients with asthma using inhaled corticosteroids: systematic review and metaanalysis
    Roman Jaeschke
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 178:1009-16. 2008
    ....
  28. doi request reprint Airway responsiveness to indirect challenges in COPD
    Nesreen M Hassan
    Firestone Institute of Respiratory Health, St Joseph s Healthcare, Hamilton, Ontario, Canada
    COPD 7:133-40. 2010
    ..The clinical relevance of hyperresponsiveness to an indirect challenge, including the impact on the natural history, relation to types of bronchitis, baseline airway calibre, and response to treatment need to be studied...
  29. pmc Quantitative sputum cell counts to monitor bronchitis: a qualitative study of physician and patient perspectives
    Liesel D'silva
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, Ontario, Canada
    Can Respir J 20:47-51. 2013
    ..Sixty per cent of family physicians were satisfied with the test and 80% were in favour of it being funded by the government. The authors recommend more widespread use of sputum cell counts to guide the management of airway diseases...
  30. pmc Cystic fibrosis transmembrane conductance regulator gene abnormalities in patients with asthma and recurrent neutrophilic bronchitis
    Jodi Goodwin
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario
    Can Respir J 19:46-8. 2012
    ....
  31. pmc Proximity to major roadways is a risk factor for airway hyper-responsiveness in adults
    Shannon Riley
    Firsestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario
    Can Respir J 19:89-95. 2012
    ..Proximity to major roads is reported to be associated with asthma and airway hyper-responsiveness in children. Similar studies using objective measurements in adults are not available in Canada...
  32. ncbi request reprint Paranasal sinus disease and sputum eosinophilia in prednisone-dependent asthma
    Bosco T M Lui
    Division of Otolaryngology and Head and Neck Surgery, McMaster University, ON
    J Otolaryngol Head Neck Surg 39:703-9. 2010
    ....
  33. doi request reprint Asthma associated with incontinentia pigmenti and Fanconi anemia: variable airflow limitation without cellular bronchitis
    Angira Dasgupta
    Divisions of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada
    Chest 143:856-8. 2013
    ....
  34. doi request reprint Addition of intravenous aminophylline to inhaled beta(2)-agonists in adults with acute asthma
    Parameswaran Nair
    Asthma Research Group, Firestone Institute for Respiratory Health, Hamilton
    Cochrane Database Syst Rev 12:CD002742. 2012
    ..Aminophylline has been used extensively to treat exacerbations in acute asthma settings; however, it's role is unclear especially with respect to any additional benefit when added to inhaled beta(2)-agonists...
  35. pmc Cost analysis of monitoring asthma treatment using sputum cell counts
    Liesel D'silva
    Department of Medicine, Firestone Institute for Respiratory Health, St Joseph s Healthcare, McMaster University, Hamilton, Canada
    Can Respir J 15:370-4. 2008
    ..objective: To compare the cost of the SS with the CS in the treatment of patients with moderate to severe asthma...
  36. ncbi request reprint Atmospheric remote sensing to detect effects of temperature inversions on sputum cell counts in airway diseases
    Julie Wallace
    School of Geography and Earth Sciences, McMaster University, 1280 Main Street West, Hamilton, Ontario
    Environ Res 110:624-32. 2010
    ..However, we found that monthly averages of total cell counts were strongly correlated with monthly nitrogen dioxide concentrations, an association not previously identified in the literature...
  37. doi request reprint Lipid and smoker's inclusions in sputum macrophages in patients with airway diseases
    Andrew M Wilson
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
    Respir Med 105:1691-5. 2011
    ..72, p < 0.01). We conclude that smoker's inclusions within sputum macrophages is a reliable indicator of cigarette smoking and that the sputum lipid index cannot be used as an assessment of oropharyngeal reflux in cigarette smokers...
  38. ncbi request reprint Clinical models to compare the safety and efficacy of inhaled corticosteroids in patients with asthma
    Krishnan Parameswaran
    Asthma Research Group, Firestone Institute of Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario
    Can Respir J 10:27-34. 2003
    ....
  39. ncbi request reprint Pharmacological management of mild or moderate persistent asthma
    Paul M O'Byrne
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Lancet 368:794-803. 2006
    ..For patients who do not achieve asthma control despite taking drugs, measurement of the inflammatory response in the airway in induced sputum could provide further information to guide treatment...
  40. ncbi request reprint Changing pattern of sputum cell counts during successive exacerbations of airway disease
    Liesel D'silva
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
    Respir Med 101:2217-20. 2007
    ..We examined changes in the cellular nature of airway inflammation between consecutive exacerbations and their predictors in individual patients...
  41. ncbi request reprint Targeted therapy of bronchitis in obstructive airway diseases
    Angira Dasgupta
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Pharmacol Ther 140:213-22. 2013
    ..The success of these agents will depend on appropriate patient selection by accurate phenotyping or characterization of bronchitis. ..
  42. doi request reprint TNF╬▒ antagonists for acute exacerbations of COPD: a randomised double-blind controlled trial
    Shawn D Aaron
    Department of Medicine, The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    Thorax 68:142-8. 2013
    ....
  43. pmc Sputum neutrophilia can mask eosinophilic bronchitis during exacerbations
    Christopher J Allen
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Can Respir J 14:281-4. 2007
    ..Exacerbations of airway disease are eosinophilic, neutrophilic, both or neither. The primary objective of the present study was to identify whether the treatment of a neutrophilic bronchitis can unmask an associated eosinophilia...
  44. ncbi request reprint Eosinophilic bronchitis in asthma: a model for establishing dose-response and relative potency of inhaled corticosteroids
    Margaret M Kelly
    Airways Research Group, Firestone Institute for Respiratory Health, Hamilton, Canada
    J Allergy Clin Immunol 117:989-94. 2006
    ..Newer generations and formulations of inhaled corticosteroids have necessitated the development of a clinically relevant model to compare their clinical potency...
  45. ncbi request reprint The effect of pranlukast on allergen-induced bone marrow eosinophilopoiesis in subjects with asthma
    Krishnan Parameswaran
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 169:915-20. 2004
    ..We conclude that, the cysteinyl leukotriene receptor antagonist, pranlukast, attenuates allergen-induced increase in airway eosinophils by decreasing bone marrow eosinophilopoiesis and airway chemotactic and eosinophilopoietic cytokines...
  46. pmc Local and systemic immunological parameters associated with remission of asthma symptoms in children
    Susan Waserman
    Departments of Medicine, McMaster University, Hamilton, ON, Canada
    Allergy Asthma Clin Immunol 8:16. 2012
    ..These findings suggest that decreased type 1 cytokine expression as well as decreased eosinophilic inflammation is associated with the resolution of asthma symptoms...
  47. doi request reprint LXR-induced reverse cholesterol transport in human airway smooth muscle is mediated exclusively by ABCA1
    Christopher J Delvecchio
    Faculty of Science, Department of Biochemistry and Biomedical Sciences, 1280 Main Street W, McMaster University, Hamilton, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 295:L949-57. 2008
    ....
  48. ncbi request reprint Cholinergics, airway eosinophils and asthma exacerbation in the elderly
    Diana Khalil
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Indian J Chest Dis Allied Sci 53:59-61. 2011
    ..This case series emphasises the need to exercise caution while prescribing cholinergic drugs in elderly patients with asthma, particularly in patients with a history of virus-induced exacerbations and airway eosinophilia...
  49. ncbi request reprint Role for cysteinyl leukotrienes in allergen-induced change in circulating dendritic cell number in asthma
    Krishnan Parameswaran
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, Department of Medicine, McMaster University, Hamilton, Canada
    J Allergy Clin Immunol 114:73-9. 2004
    ..Dendritic cells are important antigen-presenting cells. After an allergen inhalation, their numbers rapidly decrease in circulation and increase in the airway mucosa...
  50. ncbi request reprint Cysteinyl leukotrienes promote human airway smooth muscle migration
    Krishnan Parameswaran
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 166:738-42. 2002
    ..The phosphatidylinositol-3 kinase pathway is a key signaling mechanism in the chemotactic migration of ASM cells in response to cysteinyl leukotrienes...
  51. ncbi request reprint Airway hyperresponsiveness and calcium handling by smooth muscle: a "deeper look"
    Krishnan Parameswaran
    Asthma Research Group, Department of Medicine, St Joseph s Healthcare and McMaster University, Hamilton, ON, Canada
    Chest 121:621-4. 2002
    ..The amplitude, frequency, or localization of Ca(2+) oscillations in the smooth muscle may determine the degree of airway sensitivity and reactivity, which are characteristic features of asthma...
  52. pmc Persistence of pulmonary tertiary lymphoid tissues and anti-nuclear antibodies following cessation of cigarette smoke exposure
    Mathieu C Morissette
    Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada
    Respir Res 15:49. 2014
    ..Moreover, our study further emphasizes the importance of interleukin-1 (IL-1) signaling pathways in cigarette smoke-related pulmonary pathogenesis. ..
  53. ncbi request reprint Role of extracellular matrix and its regulators in human airway smooth muscle biology
    Krishnan Parameswaran
    Firestone Institute for Respiratory Health, McMaster University and St Joseph s Healthcare, Hamilton, Ontario, Canada
    Cell Biochem Biophys 44:139-46. 2006
    ..Thus, the intertwined relationship of ASM and ECM and their response to stimuli such as chronic inflammation in diseases such as asthma and COPD contribute to the remodeling seen in airways of patients with these diseases...
  54. ncbi request reprint Liver X receptor stimulates cholesterol efflux and inhibits expression of proinflammatory mediators in human airway smooth muscle cells
    Christopher J Delvecchio
    Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
    Mol Endocrinol 21:1324-34. 2007
    ..Our findings reveal biological roles for LXR in ASM cells and suggest that modulation of LXR activity offers prospects for new therapeutic approaches in the treatment of asthma and other inflammatory respiratory diseases...
  55. ncbi request reprint The effect of cysteinyl leukotrienes on growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjects
    Fausto Braccioni
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare, and the Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 110:96-101. 2002
    ..However, the effect of cysLTs on peripheral blood and bone marrow eosinophil pro-genitor cells in allergic subjects is not known...
  56. ncbi request reprint [Combining LABA and ICS in patients with severe COPD]
    Krishnan Parameswaran
    Pol Arch Med Wewn 117:6-8. 2007
  57. ncbi request reprint Treatment strategy for asthma: one for all and all for one?
    Krishnan Parameswaran
    Chest 129:221-3. 2006
  58. ncbi request reprint Leukotriene receptor antagonists for allergic rhinitis: a systematic review and meta-analysis
    Andrew M Wilson
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Med 116:338-44. 2004
    ..To compare the clinical efficacy of leukotriene receptor antagonists with that of placebo, antihistamines, and nasal corticosteroids in patients with allergic rhinitis or nasal polyposis...