Edward J Mills

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. pmc Adherence to HAART: a systematic review of developed and developing nation patient-reported barriers and facilitators
    Edward J Mills
    Centre for International Health and Human Rights Studies, Toronto, Ontario, Canada
    PLoS Med 3:e438. 2006
  2. doi request reprint Prevalence of mental disorders and torture among Bhutanese refugees in Nepal: a systemic review and its policy implications
    Edward Mills
    Faculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada
    Med Confl Surviv 24:5-15. 2008
  3. doi request reprint Male sex and the risk of mortality among individuals enrolled in antiretroviral therapy programs in Africa: a systematic review and meta-analysis
    Eric Druyts
    Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada
    AIDS 27:417-25. 2013
  4. doi request reprint Life expectancy of persons receiving combination antiretroviral therapy in low-income countries: a cohort analysis from Uganda
    Edward J Mills
    University of Ottawa, Ottawa, Ontario, Canada
    Ann Intern Med 155:209-16. 2011
  5. pmc Naturopathic care for chronic low back pain: a randomized trial
    Orest Szczurko
    Division of Clinical Epidemiology, Canadian College of Naturopathic Medicine, Toronto, Ontario, Canada
    PLoS ONE 2:e919. 2007
  6. doi request reprint Long-term health care interruptions among HIV-positive patients in Uganda
    Edward J Mills
    University of Ottawa, Ottawa, Ontario, Canada
    J Acquir Immune Defic Syndr 63:e23-7. 2013
  7. pmc Male gender predicts mortality in a large cohort of patients receiving antiretroviral therapy in Uganda
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    J Int AIDS Soc 14:52. 2011
  8. ncbi request reprint Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis
    Edward J Mills
    Centre for International Health and Human Rights Studies, Toronto, Ontario, Canada
    JAMA 296:679-90. 2006
  9. pmc Increased mortality among HIV-positive men on antiretroviral therapy: survival differences between sexes explained by late initiation in Uganda
    Steve Kanters
    Faculty of Health Science, Simon Fraser University, Burnaby, BC, Canada Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada
    HIV AIDS (Auckl) 5:111-9. 2013
  10. ncbi request reprint Providing antiretroviral care in conflict settings
    Edward J Mills
    BC Centre for Excellence in HIV AIDS, Vancouver, BC, Canada
    Curr HIV/AIDS Rep 6:201-9. 2009

Collaborators

Detail Information

Publications107 found, 100 shown here

  1. pmc Adherence to HAART: a systematic review of developed and developing nation patient-reported barriers and facilitators
    Edward J Mills
    Centre for International Health and Human Rights Studies, Toronto, Ontario, Canada
    PLoS Med 3:e438. 2006
    ..We systematically reviewed the literature to determine patient-reported barriers and facilitators to adhering to antiretroviral therapy...
  2. doi request reprint Prevalence of mental disorders and torture among Bhutanese refugees in Nepal: a systemic review and its policy implications
    Edward Mills
    Faculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada
    Med Confl Surviv 24:5-15. 2008
    ..The international community must resolve this protracted crisis...
  3. doi request reprint Male sex and the risk of mortality among individuals enrolled in antiretroviral therapy programs in Africa: a systematic review and meta-analysis
    Eric Druyts
    Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada
    AIDS 27:417-25. 2013
    ..HIV/AIDS has historically had a sex and gender-focused approach to prevention and care. Some evidence suggests that HIV-positive men have worse treatment outcomes than their women counterparts in Africa...
  4. doi request reprint Life expectancy of persons receiving combination antiretroviral therapy in low-income countries: a cohort analysis from Uganda
    Edward J Mills
    University of Ottawa, Ottawa, Ontario, Canada
    Ann Intern Med 155:209-16. 2011
    ..Little is known about the effect of combination antiretroviral therapy (cART) on life expectancy in sub-Saharan Africa...
  5. pmc Naturopathic care for chronic low back pain: a randomized trial
    Orest Szczurko
    Division of Clinical Epidemiology, Canadian College of Naturopathic Medicine, Toronto, Ontario, Canada
    PLoS ONE 2:e919. 2007
    ..Chronic low back pain represents a substantial cost to employers through benefits coverage and days missed due to incapacity. We sought to explore the effectiveness of Naturopathic care on chronic low back pain...
  6. doi request reprint Long-term health care interruptions among HIV-positive patients in Uganda
    Edward J Mills
    University of Ottawa, Ottawa, Ontario, Canada
    J Acquir Immune Defic Syndr 63:e23-7. 2013
    ..We examined risk factors for health care interruptions and loss to follow-up within a cohort receiving ART in Uganda...
  7. pmc Male gender predicts mortality in a large cohort of patients receiving antiretroviral therapy in Uganda
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    J Int AIDS Soc 14:52. 2011
    ....
  8. ncbi request reprint Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis
    Edward J Mills
    Centre for International Health and Human Rights Studies, Toronto, Ontario, Canada
    JAMA 296:679-90. 2006
    ..Concerns about incomplete adherence among patients living in poverty have been an important consideration in expanding the access to antiretroviral therapy in sub-Saharan Africa...
  9. pmc Increased mortality among HIV-positive men on antiretroviral therapy: survival differences between sexes explained by late initiation in Uganda
    Steve Kanters
    Faculty of Health Science, Simon Fraser University, Burnaby, BC, Canada Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada
    HIV AIDS (Auckl) 5:111-9. 2013
    ..We also specifically examined the role of antenatal services in favoring women's access to HIV care...
  10. ncbi request reprint Providing antiretroviral care in conflict settings
    Edward J Mills
    BC Centre for Excellence in HIV AIDS, Vancouver, BC, Canada
    Curr HIV/AIDS Rep 6:201-9. 2009
    ..Emerging guidelines from United Nations bodies now support the expansion of cART in settings of conflict...
  11. pmc Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974
    Kieran Cooley
    Department of Research and Clinical Epidemiology, The Canadian College of Naturopathic Medicine, Toronto, Canada
    PLoS ONE 4:e6628. 2009
    ..This study sought to explore the effectiveness of naturopathic care on anxiety symptoms using a randomized trial...
  12. doi request reprint Cohort profile: the MUg Observational Cohort
    Anna Funk
    Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada and The Mildmay Centre, Kampala, Uganda
    Int J Epidemiol 41:1594-1594f. 2012
    ..Data comprise demographic, behavioural and clinical variables. Collaborations and enquiries relating to the MUg observational cohort are encouraged, and can be addressed to Dr Edward Mills at edward.mills@uottowa.ca...
  13. doi request reprint Efficacy and safety of pegylated interferon alfa-2a or alfa-2b plus ribavirin for the treatment of chronic hepatitis C in children and adolescents: a systematic review and meta-analysis
    Eric Druyts
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    Clin Infect Dis 56:961-7. 2013
    ..A systematic review and meta-analysis were conducted to examine the efficacy and safety of pegylated interferon (peg-IFN) alfa-2a and peg-IFN alfa-2b plus ribavirin (RBV) in children and adolescents with chronic hepatitis C virus (HCV)...
  14. doi request reprint The prognostic value of baseline CD4(+) cell count beyond 6 months of antiretroviral therapy in HIV-positive patients in a resource-limited setting
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    AIDS 26:1425-9. 2012
    ..We examined whether initial CD4 cell count maintains a strong prognostic value among patients with at least 6 months follow-up after the initiation of ART...
  15. doi request reprint Mortality by baseline CD4 cell count among HIV patients initiating antiretroviral therapy: evidence from a large cohort in Uganda
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Canada
    AIDS 25:851-5. 2011
    ..Funders have been reticent to recommend earlier initiation of treatment. We aimed to examine the effect of baseline CD4 cell count on mortality using data from HIV patients receiving combination antiretroviral therapy (cART) in Uganda...
  16. doi request reprint HIV/AIDS in African militaries: an ecological analysis
    Oumar Ba
    Faculty of Health Sciences, Simon Fraser University, Vancouver, Canada
    Med Confl Surviv 24:88-100. 2008
    ..4). Population levels predicted military prevalence rates (P < or = 0.001). HIV/AIDS prevalence rates in most African militaries are significantly elevated compared to their host communities...
  17. doi request reprint Does ratification of human-rights treaties have effects on population health?
    Alexis Palmer
    Faculty of Health Sciences, Simon Fraser University, Vancouver, BC, Canada
    Lancet 373:1987-92. 2009
    ....
  18. pmc The financial cost of doctors emigrating from sub-Saharan Africa: human capital analysis
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Canada
    BMJ 343:d7031. 2011
    ..To estimate the lost investment of domestically educated doctors migrating from sub-Saharan African countries to Australia, Canada, the United Kingdom, and the United States...
  19. pmc Design, analysis, and presentation of crossover trials
    Edward J Mills
    Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada
    Trials 10:27. 2009
    ..Although crossover trials enjoy wide use, standards for analysis and reporting have not been established. We reviewed methodological aspects and quality of reporting in a representative sample of published crossover trials...
  20. doi request reprint Intensive statin therapy compared with moderate dosing for prevention of cardiovascular events: a meta-analysis of >40 000 patients
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada V5Z 4B4 K1n6X1
    Eur Heart J 32:1409-15. 2011
    ..There is widespread interest in whether intensive dosing of statins yields larger treatment effects. We aimed to determine if intensive dosing is clinically important using a meta-analysis of randomized clinical trials (RCTs)...
  21. pmc Dangerous journey: documenting the experience of Tibetan refugees
    Sonam Dolma
    Department of Political Science, York University, Toronto, Ontario
    Am J Public Health 96:2061-4. 2006
    ..Since the 1950 invasion of Tibet by China, Tibetan refugees have attempted to flee into Nepal over the Himalayan mountains. We documented the experiences of a group of refugees making this journey...
  22. pmc Metastatic renal cell cancer treatments: an indirect comparison meta-analysis
    Edward J Mills
    Faculty of Health Sciences, Simon Fraser University, Vancouver, Canada
    BMC Cancer 9:34. 2009
    ..New treatment options may provide improved progression-free survival (PFS). We aimed to determine the relative effectiveness of new therapies in this field...
  23. doi request reprint Why the findings of published multiple treatment comparison meta-analyses of biologic treatments for rheumatoid arthritis are different: an overview of recurrent methodological shortcomings
    Kristian Thorlund
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Ann Rheum Dis 72:1524-35. 2013
    ....
  24. ncbi request reprint How to use an article reporting a multiple treatment comparison meta-analysis
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Room 031, Thompson Hall, 35 University Private, Ottawa, ON, K1N 7K4, Canada
    JAMA 308:1246-53. 2012
    ..This article uses the existing Users' Guides format to address study validity, interpretation of results, and application to a patient scenario...
  25. doi request reprint Comparisons of high-dose and combination nicotine replacement therapy, varenicline, and bupropion for smoking cessation: a systematic review and multiple treatment meta-analysis
    Edward J Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Ann Med 44:588-97. 2012
    ..This review compared the effect of high-dose nicotine replacement therapy (NRT) and combinations of NRT for increasing smoking abstinence rates compared to standard-dose NRT patch, varenicline, and bupropion on smoking abstinence...
  26. doi request reprint Low-dose aspirin and cancer mortality: a meta-analysis of randomized trials
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ontario, Canada
    Am J Med 125:560-7. 2012
    ..We aimed to determine whether cancer mortality also is reduced by low-dose aspirin in the shorter term...
  27. pmc Differences in clinical outcomes among hepatitis C genotype 1-infected patients treated with peginterferon alpha-2a or peginterferon alpha-2b plus ribavirin: a meta-analysis
    Eric Druyts
    Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada
    Clin Exp Gastroenterol 5:11-21. 2012
    ....
  28. doi request reprint Design and methods of the MAINTAIN study: a randomized controlled clinical trial of micronutrient and antioxidant supplementation in untreated HIV infection
    Neera Singhal
    Department of Medicine, University of Ottawa at Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    Contemp Clin Trials 31:604-11. 2010
    ..We discuss here the study design and methods, often used for evaluation of complementary and adjunctive treatments for health maintenance in HIV infection, which are common interventions...
  29. ncbi request reprint The impact of conflict on HIV/AIDS in sub-Saharan Africa
    Edward J Mills
    Centre for International Health and Human Rights Studies, Toronto, Canada
    Int J STD AIDS 17:713-7. 2006
    ..We examine the complexity of monitoring HIV/AIDS in conflict settings. We argue that increased efforts are needed to protect vulnerable populations and design health-delivery systems that are sustainable in settings of conflict...
  30. doi request reprint Risk of resistance to highly active antiretroviral therapy among HIV-positive injecting drug users: a meta-analysis
    Daniel Werb
    British Columbia Centre for Excellence in HIV AIDS, University of British Columbia, 608 1081 Burrard Street, Vancouver, BC, Canada
    Lancet Infect Dis 10:464-9. 2010
    ..Therapeutic guidelines should consider reassessment of this issue...
  31. pmc Antifungal treatment for invasive Candida infections: a mixed treatment comparison meta-analysis
    Edward J Mills
    Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada
    Ann Clin Microbiol Antimicrob 8:23. 2009
    ..Treatment guidelines vary on optimal treatment strategies. We aimed to determine the effects of different antifungal therapies on global response rates, mortality and safety...
  32. doi request reprint Primary prevention of cardiovascular mortality and events with statin treatments: a network meta-analysis involving more than 65,000 patients
    Edward J Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Am Coll Cardiol 52:1769-81. 2008
    ..This study aimed to evaluate the effectiveness of 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors (statins) in primary prevention of cardiovascular events...
  33. pmc Multiple treatment comparison meta-analyses: a step forward into complexity
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada
    Clin Epidemiol 3:193-202. 2011
    ..We conclude that MTC meta-analysis is a useful tool in the context of comparative effectiveness and requires further study, as its utility and transparency will likely predict its uptake by the research and clinical community...
  34. doi request reprint The effectiveness of anti-illicit-drug public-service announcements: a systematic review and meta-analysis
    Dan Werb
    British Columbia Centre for Excellence in HIV AIDS, Vancouver, Canada
    J Epidemiol Community Health 65:834-40. 2011
    ..Anti-illicit-drug public-service announcements (PSAs) have become a cornerstone of drug policy in the USA. However, studies of the effectiveness of these interventions have not been subjected to a systematic evaluation...
  35. ncbi request reprint Participation in HIV vaccine trials: listening to participant & community concerns
    Edward J Mills
    B C Centre for Excellence in HIV AIDS, St Paul s Hospital Vancouver BC
    Indian J Med Res 124:608-10. 2006
  36. ncbi request reprint Barriers to participation in clinical trials of cancer: a meta-analysis and systematic review of patient-reported factors
    Edward J Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Lancet Oncol 7:141-8. 2006
    ..Enrolling participants onto clinical trials of cancer presents an important challenge. We aimed to identify the concerns of patients with cancer about, and the barriers to, participation in clinical trials...
  37. pmc Designing research in vulnerable populations: lessons from HIV prevention trials that stopped early
    Edward J Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, HSC 2C12, 1200 Main Street West, Hamilton, ON, Canada L8N 3Z5
    BMJ 331:1403-6. 2005
  38. ncbi request reprint A randomized trial of Pegaptanib sodium for age-related macular degeneration used an innovative design to explore disease-modifying effects
    Edward Mills
    Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Clin Epidemiol 60:456-60. 2007
    ..We aimed to determine if this design would permit inferences regarding disease modification in a trial evaluating Pegaptanib sodium, an intra-ocular injection, for the treatment of age-related macular degeneration...
  39. ncbi request reprint Tenofovir trials raise ethical issues
    Edward Mills
    Centre for International Human Rights Law, University of Oxford, Canada
    HIV AIDS Policy Law Rev 10:31-2. 2005
    ....
  40. ncbi request reprint Impact of African herbal medicines on antiretroviral metabolism
    Edward Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    AIDS 19:95-7. 2005
    ..Initiating policies to provide herbal medicines with antiretroviral agents may put patients at risk of treatment failure, viral resistance or drug toxicity...
  41. ncbi request reprint Milk thistle and indinavir: a randomized controlled pharmacokinetics study and meta-analysis
    Edward Mills
    Faculty of Health Sciences, Clinical Epidemiology and Biostatistics, McMaster University, HSC 2C12, 1200 Main Street West, Hamilton, ON, L8N 3Z5, Canada
    Eur J Clin Pharmacol 61:1-7. 2005
    ..To determine whether ingestion of milk thistle affects the pharmacokinetics of indinavir...
  42. pmc African herbal medicines in the treatment of HIV: Hypoxis and Sutherlandia. An overview of evidence and pharmacology
    Edward Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West Hamilton, L8N 3Z5, Canada
    Nutr J 4:19. 2005
    ..Efforts should also be directed at evaluating the possible benefits of natural products in HIV/AIDS treatment...
  43. pmc Interaction of St John's wort with conventional drugs: systematic review of clinical trials
    Edward Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada L8N 3Z5
    BMJ 329:27-30. 2004
    ..To determine the methodological quality of clinical trials that examined possible interactions of St John's wort with conventional drugs, and to examine the results of these trials...
  44. ncbi request reprint Barriers to participation in HIV drug trials: a systematic review
    Edward Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Lancet Infect Dis 6:32-8. 2006
    ..The findings of this study should aid drug trialists in developing strategies to maximise participation and cooperation in HIV clinical drug trials while adequately informing and protecting prospective participants...
  45. pmc Determining the reporting quality of RCTs in clinical pharmacology
    Edward Mills
    University of Oxford, Oxford, UK
    Br J Clin Pharmacol 58:61-5. 2004
    ..The Consolidated Standards for Reporting Trials (CONSORT) are recommendations for improving the quality of reports of randomized controlled trials (RCTs)...
  46. ncbi request reprint An analysis of general medical and specialist journals that endorse CONSORT found that reporting was not enforced consistently
    Edward Mills
    Department of Clinical Epidemiology and Biostatistics, HSC 2C12, Faculty of Health Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    J Clin Epidemiol 58:662-7. 2005
    ..We aimed to determine if specialist journals implement specific Consolidated Standards for Reporting Trials (CONSORT) recommendations to the same extent as general medical journals...
  47. ncbi request reprint Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis
    Edward Mills
    Department of Clinical Epidemiology, McMaster University, Hamilton, ON, Canada
    J Pineal Res 39:360-6. 2005
    ..Confirming the efficacy and safety of melatonin in cancer treatment will require completion of blinded, independently conducted RCTs...
  48. ncbi request reprint Natural health product-drug interactions: a systematic review of clinical trials
    Edward Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Ther Drug Monit 27:549-57. 2005
    ..With the exception of St. John wort, clinicians and the public do not have information that permits strong inferences about interactions between NHPs and conventional medications...
  49. ncbi request reprint Complementary therapies for the treatment of HIV: in search of the evidence
    Edward Mills
    Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, HSC 2C12, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada
    Int J STD AIDS 16:395-403. 2005
    ..Vis à vis CAM's popularity, the paucity of clinical trials and their low methodological quality are concerning...
  50. ncbi request reprint Natural health product-HIV drug interactions: a systematic review
    Edward Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON L8N 3Z5, Canada
    Int J STD AIDS 16:181-6. 2005
    ..Considering patient values and the implications of these studies, further research is urgently required to determine the extent of interactions with other commonly used NHPs...
  51. pmc The effects of excluding treatments from network meta-analyses: survey
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    BMJ 347:f5195. 2013
    ..To examine whether the exclusion of individual treatment comparators, including placebo/no treatment, affects the results of network meta-analysis...
  52. pmc Sample size and power considerations in network meta-analysis
    Kristian Thorlund
    Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4 K1
    Syst Rev 1:41. 2012
    ..This issue, however, has so far only received little attention in network meta-analysis. To date, no approaches have been proposed for evaluating the adequacy of the sample size, and thus power, in a treatment network...
  53. ncbi request reprint A wake-up call for global access to salvage HIV drug regimens
    Edward J Mills
    British Columbia Centre for Excellence in HIV AIDS, Vancouver, BC, Canada
    Lancet 370:1885-7. 2007
  54. doi request reprint HIV status in discordant couples in sub-Saharan Africa: a systematic review and meta-analysis
    Oghenowede Eyawo
    Faculty of Health Sciences, Simon Fraser University, Vancouver, BC, Canada
    Lancet Infect Dis 10:770-7. 2010
    ..We investigated serodiscordance in stable relationships to establish the gender balance of index-case infections...
  55. ncbi request reprint Epidemiology and reporting of randomized trials employing re-randomization of patient groups: a systematic survey
    Edward J Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    Contemp Clin Trials 28:268-75. 2007
    ....
  56. pmc Estimating the power of indirect comparisons: a simulation study
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    PLoS ONE 6:e16237. 2011
    ..While indirect methods have grown in popularity and acceptance, little is known about the fragility of confidence interval estimations and hypothesis testing relying on this method...
  57. ncbi request reprint Safety and efficacy of ginkgo (Ginkgo biloba) during pregnancy and lactation
    Jean Jacques Dugoua
    Department of Clinical Epidemiology, Canadian College of Naturopathic Medicine, Toronto, Canada
    Can J Clin Pharmacol 13:e277-84. 2006
    ..This is one article in a series that systematically reviews the evidence for commonly used herbs during pregnancy and lactation...
  58. ncbi request reprint Safety and efficacy of panax ginseng during pregnancy and lactation
    Dugald Seely
    Department of Research and Clinical Epidemiology, The Canadian College of Naturopathic Medicine, Toronto, Canada
    Can J Clin Pharmacol 15:e87-94. 2008
    ..This is one article in a series that systematically reviews the evidence for herbs commonly used during pregnancy and lactation...
  59. ncbi request reprint Safety and efficacy of St. John's wort (hypericum) during pregnancy and lactation
    Jean Jacques Dugoua
    Department of Clinical Epidemiology, Canadian College of Naturopathic Medicine, Toronto, Canada
    Can J Clin Pharmacol 13:e268-76. 2006
    ..This is one article in a series that systematically reviews the evidence for commonly used herbs during pregnancy and lactation...
  60. pmc Anti-tumor necrosis factor (TNF) drugs for the treatment of psoriatic arthritis: an indirect comparison meta-analysis
    Kristian Thorlund
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Biologics 6:417-27. 2012
    ....
  61. pmc The Cameroon Mobile Phone SMS (CAMPS) trial: a randomized trial of text messaging versus usual care for adherence to antiretroviral therapy
    Lawrence Mbuagbaw
    Centre for the Development of Best Practices in Health CDBPH, Yaounde Central Hospital, Yaounde, Centre, Cameroon
    PLoS ONE 7:e46909. 2012
    ..This trial investigates the use of motivational mobile phone text messages (SMS) to improve adherence to antiretroviral therapy (ART) over six months...
  62. doi request reprint Calculating additive treatment effects from multiple randomized trials provides useful estimates of combination therapies
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, 43 Templeton Street, Ottawa, Ontario, Canada Electronic address
    J Clin Epidemiol 65:1282-8. 2012
    ..We discuss here the prerequisites and methods of applying additivity assumptions in synthesizing the evidence from randomized trials and multiple treatment meta-analyses...
  63. pmc Adverse events associated with nicotine replacement therapy (NRT) for smoking cessation. A systematic review and meta-analysis of one hundred and twenty studies involving 177,390 individuals
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    Tob Induc Dis 8:8. 2010
    ..Although expectations of mild adverse effects have been observed to be independent predictors of reduced motivation to use NRT, adverse effects associated with NRT have not been precisely quantified...
  64. ncbi request reprint Migration and transmission of blood-borne infections among injection drug users: understanding the epidemiologic bridge
    Beth Rachlis
    BC Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, British Columbia, Canada
    Drug Alcohol Depend 90:107-19. 2007
    ..We also discuss the potential policy implications of addressing prevention and care issues in mobile drug using populations...
  65. pmc Health system determinants of infant, child and maternal mortality: A cross-sectional study of UN member countries
    Katherine A Muldoon
    British Columbia Centre for Excellence in HIV AIDS, St, Paul s Hospital, 1081 Burrard Street, Vancouver, British Columbia, Canada
    Global Health 7:42. 2011
    ..abstract:..
  66. pmc EDTA chelation therapy for cardiovascular disease: a systematic review
    Dugald M R Seely
    Canadian College of Naturopathic Medicine, Toronto, Canada
    BMC Cardiovasc Disord 5:32. 2005
    ..To address this issue we conducted a systematic review to evaluate the best available evidence for the use of EDTA chelation therapy in the treatment of cardiovascular disease...
  67. ncbi request reprint Systematically reviewing qualitative studies complements survey design: an exploratory study of barriers to paediatric immunisations
    Edward J Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Health Science Centre, Hamilton, Ontario, Canada
    J Clin Epidemiol 58:1101-8. 2005
    ..We examined surveys addressing parental barriers to vaccinating children to determine if they comprehensively included themes identified in published qualitative studies...
  68. pmc In the era of systematic reviews, does the size of an individual trial still matter
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    PLoS Med 5:e4. 2008
    ..Others point out that small trials can still be potentially misleading...
  69. pmc Tuberculosis mortality in HIV-infected individuals: a cross-national systematic assessment
    Christopher Au-Yeung
    BC Centre for Excellence in HIV AIDS, Vancouver, Canada
    Clin Epidemiol 3:21-9. 2011
    ..Tuberculosis (TB) is a leading cause of death in human immunodeficiency virus (HIV)-positive individuals. We sought to compare mortality rates in TB/HIV co-infected individuals globally and by country/territory...
  70. doi request reprint Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis
    Dirk Bassler
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    JAMA 303:1180-7. 2010
    ..Theory and simulation suggest that randomized controlled trials (RCTs) stopped early for benefit (truncated RCTs) systematically overestimate treatment effects for the outcome that precipitated early stopping...
  71. ncbi request reprint Safety and efficacy of black cohosh (Cimicifuga racemosa) during pregnancy and lactation
    Jean Jacques Dugoua
    Department of Clinical Epidemiology, Canadian College of Naturopathic Medicine, Toronto, Canada
    Can J Clin Pharmacol 13:e257-61. 2006
    ..This is one article in a series that systematically reviews the evidence for commonly used herbs during pregnancy and lactation...
  72. ncbi request reprint Mitigation of antiretroviral-induced hyperlipidemia by hepatitis C virus co-infection
    Curtis L Cooper
    Division of Infectious Diseases, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
    AIDS 21:71-6. 2007
    ..Hyperlipidemia is a recognized complication of HIV antiretroviral therapy. The interactions between HIV, hepatitis C virus (HCV), antiretroviral agents and lipids are not well understood...
  73. pmc Health food store recommendations: implications for breast cancer patients
    Edward Mills
    Department of Research, Canadian College of Naturopathic Medicine, North York, Ontario, Canada
    Breast Cancer Res 5:R170-4. 2003
    ..Many breast cancer patients use complementary and alternative medicine (CAM). We aimed to determine what advice health food store employees present to individuals seeking treatment options for breast cancer...
  74. ncbi request reprint Safety and efficacy of chastetree (Vitex agnus-castus) during pregnancy and lactation
    Jean Jacques Dugoua
    Graduate Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University ofToronto, Toronto, Canada
    Can J Clin Pharmacol 15:e74-9. 2008
    ..This is one article in a series that systematically reviews the evidence for herbs commonly used during pregnancy and lactation...
  75. ncbi request reprint Randomized trials stopped early for harm in HIV/AIDS: a systematic survey
    Edward Mills
    Centre for International Health and Human Rights Studies, North York, Ontario, Canada
    HIV Clin Trials 7:24-33. 2006
    ..We assessed the prevalence of randomized clinical trials (RCTs) stopped early for harm in HIV/AIDS and determined the quality of reporting of methods to inform the decision to stop the trial...
  76. ncbi request reprint Safety and efficacy of blue cohosh (Caulophyllum thalictroides) during pregnancy and lactation
    Jean Jacques Dugoua
    Graduate Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University ofToronto, Toronto, Canada
    Can J Clin Pharmacol 15:e66-73. 2008
    ..This is one article in a series that systematically reviews the evidence for commonly used herbs during pregnancy and lactation...
  77. pmc Predictive value of CD4 cell count nadir on long-term mortality in HIV-positive patients in Uganda
    Sarah Bray
    Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    HIV AIDS (Auckl) 4:135-40. 2012
    ..The lowest level that their CD4 cell count reaches, the nadir, may have long-term consequences in terms of mortality. We examined this health state in a large cohort of HIV+ patients in Uganda...
  78. pmc Engaging Men in Prevention and Care for HIV/AIDS in Africa
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    PLoS Med 9:e1001167. 2012
    ..Ed Mills and colleagues argue that a more balanced approach to gender is needed so that both men and women are involved in HIV treatment and prevention...
  79. pmc Pharmacotherapies for chronic obstructive pulmonary disease: a multiple treatment comparison meta-analysis
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada
    Clin Epidemiol 3:107-29. 2011
    ..Since current guidelines cannot make strong recommendations yet, our aim was to determine the relative efficacy of existing treatments and combinations to reduce the risk for COPD exacerbations...
  80. pmc Livelihood security and adherence to antiretroviral therapy in low and middle income settings: a systematic review
    Beth S Rachlis
    Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
    PLoS ONE 6:e18948. 2011
    ..We sought to examine the association between livelihood security and adherence to antiretroviral therapy (ARVs) in low- and middle-income countries (LIMC)...
  81. doi request reprint Naturopathic treatment of rotator cuff tendinitis among Canadian postal workers: a randomized controlled trial
    Orest Szczurko
    Canadian College of Naturopathic Medicine, Toronto, Ontario, Canada
    Arthritis Rheum 61:1037-45. 2009
    ..To explore the effectiveness of naturopathic care (NC) on rotator cuff tendinitis using a prospective randomized clinical trial design...
  82. ncbi request reprint The effects of green tea consumption on incidence of breast cancer and recurrence of breast cancer: a systematic review and meta-analysis
    Dugald Seely
    Department of Clinical Epidemiology, Canadian College of Naturopathic Medicine, Toronto, Ontario, Canada
    Integr Cancer Ther 4:144-55. 2005
    ..Green tea is widely used by women for the prevention and treatment of breast cancer. The authors aimed to determine the efficacy of green tea ingestion on the risk of breast cancer development and the risk of breast cancer recurrence...
  83. ncbi request reprint Disclosure of natural product use to primary care physicians: a cross-sectional survey of naturopathic clinic attendees
    Jason W Busse
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Mayo Clin Proc 80:616-23. 2005
    ..To determine factors that predict disclosure of natural product use by patients to their primary care physicians...
  84. ncbi request reprint The quality of randomized trial reporting in leading medical journals since the revised CONSORT statement
    Edward J Mills
    Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, HSC 2C12, 1200 Main Street West, Hamilton, ON, Canada, L8N 3Z5
    Contemp Clin Trials 26:480-7. 2005
    ..Although reporting of some CONSORT recommendations is high, reporting of several essential recommendations remains suboptimal. Authors need to comply with and journals need to enforce reporting of the revised CONSORT recommendations...
  85. ncbi request reprint Teaching evidence-based complementary and alternative medicine: 2. A conceptual approach to causation-part 2
    Kumanan Wilson
    Department of Medicine, University of Toronto, Ontario, Canada
    J Altern Complement Med 8:385-9. 2002
    ..more likely to lead to disease? Is there evidence from several different studies showing the same association? Does withdrawal of the cause result in loss of the effect? Is there a biologic model that can explain the causal relationship?..
  86. ncbi request reprint Closing comment: Evidence-based complementary and alternative medicine: is it a viable concept?
    Kumanan Wilson
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Altern Complement Med 8:875-6. 2002
  87. pmc Enrolling women into HIV preventive vaccine trials: an ethical imperative but a logistical challenge
    Edward Mills
    Centre for International Health and Human Rights Studies, Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    PLoS Med 3:e94. 2006
  88. ncbi request reprint From type 2 diabetes to antioxidant activity: a systematic review of the safety and efficacy of common and cassia cinnamon bark
    Jean Jacques Dugoua
    Graduate Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON M5S 3M2, Canada
    Can J Physiol Pharmacol 85:837-47. 2007
    ..pylori infection. Common cinnamon showed weak to very weak evidence of efficacy in treating oral candidiasis in HIV patients and chronic salmonellosis...
  89. ncbi request reprint Teaching evidence-based complementary and alternative medicine: 2. A conceptual approach to causation-part 1
    Kumanan Wilson
    Department of Medicine, University of Toronto, Ontario, Canada
    J Altern Complement Med 8:379-83. 2002
    ....
  90. doi request reprint Prevalence of mental disorders among children exposed to war: a systematic review of 7,920 children
    Vindya Attanayake
    Faculty of Health Sciences, Simon Fraser University, Vancouver, BC, Canada
    Med Confl Surviv 25:4-19. 2009
    ..Given the number of current conflicts, there is a paucity of information regarding mental disorders among children affected by war...
  91. doi request reprint Reporting of informed consent, standard of care and post-trial obligations in global randomized intervention trials: a systematic survey of registered trials
    Emma R M Cohen
    Simon Fraser University, Burnaby, British Columbia, Canada
    Dev World Bioeth 9:74-80. 2009
    ....
  92. ncbi request reprint Characteristics of pediatric and adolescent patients attending a naturopathic college clinic in Canada
    Kumanan Wilson
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Pediatrics 115:e338-43. 2005
    ..We also determined factors associated with the use of CAM products and vaccination status...
  93. ncbi request reprint In vitro analysis of the herbal compound Essiac
    Dugald Seely
    Department of Research and Clinical Epidemiology, The Canadian College of Naturopathic Medicine, Toronto, ON, Canada
    Anticancer Res 27:3875-82. 2007
    ..We aimed to address this deficiency by conducting a series of assays to determine some of the purported activities of Essiac in vitro...
  94. ncbi request reprint Randomized trials stopped early for benefit: a systematic review
    Victor M Montori
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    JAMA 294:2203-9. 2005
    ..Their prevalence, the magnitude and plausibility of their treatment effects, and the extent to which they report information about how investigators decided to stop early are, however, unknown...
  95. ncbi request reprint An in vivo analysis of the herbal compound essiac
    Blair J N Leonard
    Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Anticancer Res 26:3057-63. 2006
    ..Despite its relatively widespread use, there are no peer-reviewed published reports of in vivo studies regarding the use of this compound...
  96. ncbi request reprint Diagnostic accuracy among the allied health professions: commentary on Grace et Al
    Dugald Seely
    Department of Clinical Epidemiology, The Canadian College of Naturopathic Medicine, North York, Ontario, Canada
    J Altern Complement Med 12:701-2. 2006
  97. ncbi request reprint Randomized controlled trials in long-term care residents with dementia: a systematic review
    Edward J Mills
    The University of Oxford
    J Am Med Dir Assoc 4:302-7. 2003
    ..To evaluate the quality of reporting of randomized controlled trials for pharmacologic interventions in long-term care residents with dementia...
  98. pmc Problems with use of composite end points in cardiovascular trials: systematic review of randomised controlled trials
    Ignacio Ferreira-Gonzalez
    Departament de Medicina, Universitat Autonoma de Barcelona, and Hospital Vall d Hebron, Barcelona 08035, Spain
    BMJ 334:786. 2007
    ....
  99. ncbi request reprint HIV infection as a weapon of war
    Edward J Mills
    Lancet Infect Dis 6:752-3. 2006
  100. ncbi request reprint Changing attitudes towards polio vaccination: a randomized trial of an evidence-based presentation versus a presentation from a polio survivor
    Kumanan Wilson
    Department of Medicine, University of Toronto, Canada
    Vaccine 23:3010-5. 2005
    ..These findings suggest that confronting deeply held beliefs regarding vaccination may paradoxically strengthen these belief systems...
  101. ncbi request reprint Lesotho embarks on universal HIV testing
    Edward J Mills
    HIV AIDS Policy Law Rev 11:27-8. 2006
    ..However, the initiative raises human rights concerns...