Maureen Meade

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint The management of patients who require temporary reversal of vitamin K antagonists for surgery: a practical guide for clinicians
    Caterina Mannucci
    Department of Medicine, McMaster University and St Joseph s Healthcare, Hamilton, Ontario, Canada
    Intern Emerg Med 1:96-104. 2006
  2. pmc Strategies to enhance venous thromboprophylaxis in hospitalized medical patients (SENTRY): a pilot cluster randomized trial
    Menaka Pai
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Implement Sci 8:1. 2013
  3. pmc Management of patients with unprovoked venous thromboembolism: an evidence-based and practical approach
    Maura Marcucci
    Departments of Medicine and Clinical Epidemiology and Biostatistics, McMaster University, St Joseph s Healthcare, F 544, 50 Charlton Ave East, Hamilton, ON, Canada, L8N 4A6
    Curr Treat Options Cardiovasc Med 15:224-39. 2013
  4. ncbi request reprint Initial and long-term treatment of deep venous thrombosis: recent clinical trials and their impact on patient management
    Aaron Liew
    McMaster University, Department of Medicine, St Joseph s Healthcare, F 544, 50 Charlton Ave East, Hamilton, ON, L8N 4A6, Canada
    Expert Opin Pharmacother 14:385-96. 2013
  5. doi request reprint Accuracy and safety of (99m)Tc-labeled anti-D-dimer (DI-80B3) Fab' fragments (ThromboView®) in the diagnosis of deep vein thrombosis: a phase II study
    James D Douketis
    Dept of Medicine, McMaster University, Hamilton, ON, Canada
    Thromb Res 130:381-9. 2012
  6. doi request reprint The effect of prothrombotic blood abnormalities on risk of deep vein thrombosis in users of hormone replacement therapy: a prospective case-control study
    Jim D Douketis
    Department of Medicine, McMaster University, Hamilton, Canada
    Clin Appl Thromb Hemost 17:E106-13. 2011
  7. ncbi request reprint The incidence and prognostic significance of elevated cardiac troponins in patients with submassive pulmonary embolism
    J D Douketis
    Department of Medicine, McMaster University, Hamilton, Canada
    J Thromb Haemost 3:508-13. 2005
  8. ncbi request reprint Low-molecular-weight heparin as bridging anticoagulation during interruption of warfarin: assessment of a standardized periprocedural anticoagulation regimen
    James D Douketis
    Department of Medicine, McMaster University, and Hamilton Health Sciences, General Hospital, Hamilton, Ontario, Canada
    Arch Intern Med 164:1319-26. 2004
  9. ncbi request reprint Comparison of bleeding in patients with nonvalvular atrial fibrillation treated with ximelagatran or warfarin: assessment of incidence, case-fatality rate, time course and sites of bleeding, and risk factors for bleeding
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Arch Intern Med 166:853-9. 2006
  10. ncbi request reprint Pharmacologic properties of the new oral anticoagulants: a clinician-oriented review with a focus on perioperative management
    James D Douketis
    Department of Medicine, McMaster University, St Joseph s Healthcare, 50 Charlton Avenue East, Hamilton, Ontario, Canada
    Curr Pharm Des 16:3436-41. 2010

Collaborators

Detail Information

Publications101 found, 100 shown here

  1. ncbi request reprint The management of patients who require temporary reversal of vitamin K antagonists for surgery: a practical guide for clinicians
    Caterina Mannucci
    Department of Medicine, McMaster University and St Joseph s Healthcare, Hamilton, Ontario, Canada
    Intern Emerg Med 1:96-104. 2006
    ....
  2. pmc Strategies to enhance venous thromboprophylaxis in hospitalized medical patients (SENTRY): a pilot cluster randomized trial
    Menaka Pai
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Implement Sci 8:1. 2013
    ..Knowledge-translation strategies are needed to bridge this gap...
  3. pmc Management of patients with unprovoked venous thromboembolism: an evidence-based and practical approach
    Maura Marcucci
    Departments of Medicine and Clinical Epidemiology and Biostatistics, McMaster University, St Joseph s Healthcare, F 544, 50 Charlton Ave East, Hamilton, ON, Canada, L8N 4A6
    Curr Treat Options Cardiovasc Med 15:224-39. 2013
    ....
  4. ncbi request reprint Initial and long-term treatment of deep venous thrombosis: recent clinical trials and their impact on patient management
    Aaron Liew
    McMaster University, Department of Medicine, St Joseph s Healthcare, F 544, 50 Charlton Ave East, Hamilton, ON, L8N 4A6, Canada
    Expert Opin Pharmacother 14:385-96. 2013
    ..Specific conditions including advanced age, obesity and renal impairment need to be considered when implementing anticoagulation treatment to ensure optimal therapeutic efficacy and safety...
  5. doi request reprint Accuracy and safety of (99m)Tc-labeled anti-D-dimer (DI-80B3) Fab' fragments (ThromboView®) in the diagnosis of deep vein thrombosis: a phase II study
    James D Douketis
    Dept of Medicine, McMaster University, Hamilton, ON, Canada
    Thromb Res 130:381-9. 2012
    ..This test has an anatomic component to locate DVT and a functional component to differentiate acute (newly formed) thrombus from inactive (old) thrombus...
  6. doi request reprint The effect of prothrombotic blood abnormalities on risk of deep vein thrombosis in users of hormone replacement therapy: a prospective case-control study
    Jim D Douketis
    Department of Medicine, McMaster University, Hamilton, Canada
    Clin Appl Thromb Hemost 17:E106-13. 2011
    ..Few studies have assessed the effect of prothrombotic blood abnormalities on the risk of deep vein thrombosis (DVT) with hormone replacement therapy (HRT)...
  7. ncbi request reprint The incidence and prognostic significance of elevated cardiac troponins in patients with submassive pulmonary embolism
    J D Douketis
    Department of Medicine, McMaster University, Hamilton, Canada
    J Thromb Haemost 3:508-13. 2005
    ..1; 95% CI: 0.2-4.9). In patients who present with submassive PE, an elevated cTnI occurs in about one in seven patients and is associated with a 3.5-fold increased risk of all-cause death...
  8. ncbi request reprint Low-molecular-weight heparin as bridging anticoagulation during interruption of warfarin: assessment of a standardized periprocedural anticoagulation regimen
    James D Douketis
    Department of Medicine, McMaster University, and Hamilton Health Sciences, General Hospital, Hamilton, Ontario, Canada
    Arch Intern Med 164:1319-26. 2004
    ..We investigated the efficacy and safety of a standardized periprocedural anticoagulation regimen with low-molecular-weight heparin...
  9. ncbi request reprint Comparison of bleeding in patients with nonvalvular atrial fibrillation treated with ximelagatran or warfarin: assessment of incidence, case-fatality rate, time course and sites of bleeding, and risk factors for bleeding
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Arch Intern Med 166:853-9. 2006
    ..Ximelagatran is a novel direct thrombin inhibitor that can be administered as a fixed oral dose, without the need for anticoagulant monitoring...
  10. ncbi request reprint Pharmacologic properties of the new oral anticoagulants: a clinician-oriented review with a focus on perioperative management
    James D Douketis
    Department of Medicine, McMaster University, St Joseph s Healthcare, 50 Charlton Avenue East, Hamilton, Ontario, Canada
    Curr Pharm Des 16:3436-41. 2010
    ....
  11. doi request reprint Combination warfarin-ASA therapy: which patients should receive it, which patients should not, and why?
    James D Douketis
    Department of Medicine, McMaster University and St Joseph s Healthcare, Hamilton, ON, Canada
    Thromb Res 127:513-7. 2011
    ....
  12. doi request reprint Perioperative management of patients receiving anticoagulant or antiplatelet therapy: a clinician-oriented and practical approach
    James D Douketis
    St Joseph s Healthcare Hamilton, Hamilton, ON, Canada
    Hosp Pract (1995) 39:41-54. 2011
    ..The objective of this article is to provide an evidence-based but practical approach relating to these 2 key issues in a manner than can be applied to everyday clinical practice...
  13. ncbi request reprint Systematic review of long-term weight loss studies in obese adults: clinical significance and applicability to clinical practice
    J D Douketis
    Department of Medicine, McMaster University, Hamilton, Canada
    Int J Obes (Lond) 29:1153-67. 2005
    ....
  14. pmc Treatment of deep vein thrombosis: what factors determine appropriate treatment?
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, Ont
    Can Fam Physician 51:217-23. 2005
    ..To identify patients with deep vein thrombosis (DVT) for whom in-hospital treatment should be considered...
  15. ncbi request reprint Hormone replacement therapy and risk for venous thromboembolism: what's new and how do these findings influence clinical practice?
    James Douketis
    Department of Medicine, McMaster University and St Joseph s Hospital, Hamilton, Ontario, Canada
    Curr Opin Hematol 12:395-400. 2005
    ..hormone replacement therapy? Does the presence of thrombophilia influence the risk for venous thromboembolism in hormone replacement therapy users? Should hormone replacement therapy be temporarily interrupted around the time of surgery?..
  16. ncbi request reprint Bridging anticoagulation with low-molecular-weight heparin after interruption of warfarin therapy is associated with a residual anticoagulant effect prior to surgery
    James D Douketis
    Department of Medicine and St Joseph s Heathcare, McMaster University, Hamilton, Canada
    Thromb Haemost 94:528-31. 2005
    ..In patients who require bridging anticoagulation with LMWH, a residual anticoagulant effect from LMWH is detected in 1 of 6 patients, and receiving therapeutic-dose LMWH is the strongest predictor of such an effect...
  17. ncbi request reprint Dabigatran as anticoagulant therapy for atrial fibrillation. Which patients should receive it, which patients may not need it, and other practical aspects of patient management
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Pol Arch Med Wewn 121:73-80. 2011
    ..within the context of how the quality of anticoagulation control affects warfarin efficacy and safety; and 3) to consider which patients with chronic atrial fibrillation should receive and which may not need to receive dabigatran...
  18. doi request reprint Patient-level meta-analysis: effect of measurement timing, threshold, and patient age on ability of D-dimer testing to assess recurrence risk after unprovoked venous thromboembolism
    James Douketis
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 153:523-31. 2010
    ..However, questions remain about the utility of measuring d-dimer in clinical practice...
  19. ncbi request reprint Anticoagulant prophylaxis in special populations with an indwelling epidural catheter or renal insufficiency
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 4A6
    J Crit Care 20:324-9. 2005
    ..This review focuses on anticoagulant prophylaxis in such patients, including reasonable approaches for using low-molecular-weight heparins as thromboprophylaxis...
  20. pmc Risk of recurrence after venous thromboembolism in men and women: patient level meta-analysis
    James Douketis
    St Joseph s Healthcare Hamilton, Hamilton, ON, Canada
    BMJ 342:d813. 2011
    ..Data source Comprehensive search of electronic databases (Medline, Embase, CINAHL, Cochrane Central Register of Controlled Trials) until July 2010, supplemented by review of conference abstracts and contact with content experts...
  21. ncbi request reprint Does the type of hormone replacement therapy influence the risk of deep vein thrombosis? A prospective case-control study
    J D Douketis
    Department of Medicine, McMaster University, Hamilton, Canada
    J Thromb Haemost 3:943-8. 2005
    ..Although hormone replacement therapy (HRT) is associated with an increased risk of deep vein thrombosis (DVT), it is not clear if the risk differs in users of combined estrogen-progestin HRT and estrogen-only HRT...
  22. ncbi request reprint The management of hypertension in the overweight and obese patient: is weight reduction sufficient?
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Drugs 64:795-803. 2004
    ..Additional studies are needed to determine the long-term (>1 year) efficacy and safety of antihypertensive and anti-obesity management strategies in the overweight and obese hypertensive patient...
  23. ncbi request reprint Prophylaxis against venous thromboembolism in hospitalized medical patients: an evidence-based and practical approach
    James D Douketis
    Department of Medicine, McMaster University and St Joseph s Healthcare, Hamilton, ON, Canada
    Pol Arch Med Wewn 118:209-15. 2008
    ..Additional research is needed to develop a validated risk stratification model for hospitalized medical patients that can help identify patients who would benefit most from anticoagulant prophylaxis...
  24. doi request reprint Prevention of venous thromboembolism in hospitalized medical patients: addressing some practical questions
    James D Douketis
    Department of Medicine, McMaster University and St Joseph s Healthcare, Hamilton, Ontario, Canada
    Curr Opin Pulm Med 14:381-8. 2008
    ....
  25. doi request reprint Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin dalteparin: an assessment of safety and pharmacodynamics: the DIRECT study
    James Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Arch Intern Med 168:1805-12. 2008
    ..To challenge this premise, we evaluated if deep vein thrombosis (DVT) prophylaxis with dalteparin sodium confers an excessive anticoagulant effect in critically ill patients with severe renal insufficiency...
  26. doi request reprint The long-term risk of cancer in patients with a first episode of venous thromboembolism
    J D Douketis
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    J Thromb Haemost 7:546-51. 2009
    ..In patients with venous thromboembolism (VTE), 15-20% will have prevalent cancer when VTE is diagnosed but little is known about such patients' long-term risk, time course and predictors of new cancer...
  27. ncbi request reprint The risk for fatal pulmonary embolism after discontinuing anticoagulant therapy for venous thromboembolism
    James D Douketis
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 147:766-74. 2007
    ..The long-term risk for fatal pulmonary embolism (PE) after treatment of venous thromboembolism (VTE) may be an important factor in the decision to discontinue this treatment...
  28. ncbi request reprint Prognosis in pulmonary embolism
    J D Douketis
    Department of Medicine, St Joseph s Hospital, McMaster University, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada
    Curr Opin Pulm Med 7:354-9. 2001
    ....
  29. ncbi request reprint Does statin therapy decrease the risk for bleeding in patients who are receiving warfarin?
    James D Douketis
    Department of Medicine, McMaster University and St Joseph s Healthcare, Hamilton, Ontario, Canada
    Am J Med 120:369.e9-369.e14. 2007
    ..Recent observations in patients with atrial fibrillation who are receiving warfarin suggest that concomitant treatment with a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin) decreases the risk for bleeding...
  30. ncbi request reprint Perioperative management of antithrombotic therapy
    James D Douketis
    Department of Medicine, McMaster University and St Joseph s Healthcare, Hamilton, ON, Canada
    Pol Arch Med Wewn 118:201-8. 2008
    ..The overall objective of this review is to provide a practical approach relating to perioperative anticoagulation which can be used in everyday clinical practice...
  31. ncbi request reprint Patient self-monitoring of oral anticoagulant therapy: potential benefits and implications for clinical practice
    J D Douketis
    Department of Medicine, McMaster University, and St Joseph s Hospital, Hamilton, Ontario, Canada
    Am J Cardiovasc Drugs 1:245-51. 2001
    ..Additionally, self-monitoring is limited to patients who have the cognitive and physical capabilities to perform the technique required for the portable coagulometer...
  32. ncbi request reprint Perioperative anticoagulation management in patients who are receiving oral anticoagulant therapy: a practical guide for clinicians
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Thromb Res 108:3-13. 2002
    ..The objectives of this review are to focus on practical issues relating to perioperative anticoagulation and the implementation of a perioperative anticoagulation management approach that can be used in everyday clinical practice...
  33. ncbi request reprint Short-duration prophylaxis against venous thromboembolism after total hip or knee replacement: a meta-analysis of prospective studies investigating symptomatic outcomes
    James D Douketis
    Department of Medicine, McMaster University, and St Joseph s Hospital, Hamilton, Ontario, Canada L8N 4A6
    Arch Intern Med 162:1465-71. 2002
    ....
  34. ncbi request reprint Anticoagulant effect at the time of epidural catheter removal in patients receiving twice-daily or once-daily low-molecular-weight heparin and continuous epidural analgesia after orthopedic surgery
    James D Douketis
    Department of Medicine, McMaster University and St Joseph s Hospital, Hamilton, Canada
    Thromb Haemost 88:37-40. 2002
    ....
  35. ncbi request reprint Elevated cardiac troponin levels in patients with submassive pulmonary embolism
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 4A6
    Arch Intern Med 162:79-81. 2002
    ..We performed a prospective cohort study to determine the prevalence of elevated cardiac troponin I (cTnI) levels in patients with submassive pulmonary embolism...
  36. pmc Venous thromboembolism and bleeding in critically ill patients with severe renal insufficiency receiving dalteparin thromboprophylaxis: prevalence, incidence and risk factors
    Deborah Cook
    Department of Medicine, 1200 Main Street, McMaster University, Hamilton, Canada
    Crit Care 12:R32. 2008
    ..The objective of the present study was to evaluate the prevalence, incidence and predictors of DVT and the incidence of bleeding in intensive care unit (ICU) patients with estimated creatinine clearance <30 ml/min...
  37. pmc Red blood cell transfusion and increased length of storage are not associated with deep vein thrombosis in medical and surgical critically ill patients: a prospective observational cohort study
    Christina Katsios
    Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, ON L8S 4L8, Canada
    Crit Care 15:R263. 2011
    ..The objective of this study was to determine if RBC transfusions or RBC storage age predicts incident DVT in medical or surgical intensive care unit (ICU) patients...
  38. doi request reprint PROphylaxis for ThromboEmbolism in Critical Care Trial protocol and analysis plan
    Deborah Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 26:223.e1-9. 2011
    ....
  39. ncbi request reprint Deep venous thrombosis in medical-surgical critically ill patients: prevalence, incidence, and risk factors
    Deborah Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care Med 33:1565-71. 2005
    ..The objective was to determine the prevalence, incidence, and risk factors for proximal lower extremity deep venous thrombosis among critically ill medical-surgical patients...
  40. ncbi request reprint The 4Ts scoring system for heparin-induced thrombocytopenia in medical-surgical intensive care unit patients
    Mark Andrew Crowther
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 25:287-93. 2010
    ..The 4Ts score (Thrombocytopenia, Timing of thrombocytopenia, Thrombosis, and oTher reason) might identify individual patients at risk of having this disorder...
  41. pmc Clinically important deep vein thrombosis in the intensive care unit: a survey of intensivists
    Deborah Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care 8:R145-52. 2004
    ..The objective of the present survey is to identify the patient factors and radiologic features of lower limb DVT that intensivists consider more or less likely to make a DVT clinically important in ICU patients...
  42. ncbi request reprint Prophylaxis of Thromboembolism in Critical Care (PROTECT) Trial: a pilot study
    Deborah J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:364-72. 2005
    ..Its additional goals were to evaluate the suitability of the exclusion criteria and to document the range of research activities that precede accrual of patients into a trial to plan multisite management...
  43. ncbi request reprint Perioperative anticoagulation in patients with chronic atrial fibrillation who are undergoing elective surgery: results of a physician survey
    J D Douketis
    St Joseph s Hospital, McMaster University, Hamilton, Canada
    Can J Cardiol 16:326-30. 2000
    ..To survey physicians' anticoagulation preferences in patients with chronic atrial fibrillation who are undergoing elective surgery...
  44. ncbi request reprint Physician preferences for perioperative anticoagulation in patients with a mechanical heart valve who are undergoing elective noncardiac surgery
    J D Douketis
    Department of Medicine, St Joseph s Hospital, Hamilton, Ontario, Canada
    Chest 116:1240-6. 1999
    ....
  45. ncbi request reprint Clinical risk factors and timing of recurrent venous thromboembolism during the initial 3 months of anticoagulant therapy
    J D Douketis
    St Joseph s Hospital, Room F 538, 50 Charlton Ave E, Hamilton, Ontario, Canada L8N 4A6
    Arch Intern Med 160:3431-6. 2000
    ....
  46. doi request reprint Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial
    Alexander G G Turpie
    McMaster University, Hamilton, Ontario L8L 2X2, Canada
    Lancet 373:1673-80. 2009
    ..We aimed to test the efficacy and safety of oral rivaroxaban for the prevention of venous thromboembolism after total knee arthroplasty...
  47. ncbi request reprint The effects of hormone replacement therapy on thrombin generation, fibrinolysis inhibition, and resistance to activated protein C: prospective cohort study and review of literature
    J D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Thromb Res 99:25-34. 2000
    ....
  48. doi request reprint Dabigatran versus warfarin in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 361:1139-51. 2009
    ..Warfarin reduces the risk of stroke in patients with atrial fibrillation but increases the risk of hemorrhage and is difficult to use. Dabigatran is a new oral direct thrombin inhibitor...
  49. ncbi request reprint Anticoagulation therapy in patients with prosthetic heart valves
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin Adv Hematol Oncol 5:436-8. 2007
  50. doi request reprint Combined warfarin-aspirin therapy: what is the evidence for benefit and harm and which patients should (and should not) receive it?
    Marco P Donadini
    Department of Medicine, McMaster University and St Joseph s Healthcare, Hamilton, ON, L8N 4A6, Canada
    J Thromb Thrombolysis 29:208-13. 2010
    ....
  51. doi request reprint Corticosteroid therapy for acute lung injury, acute respiratory distress syndrome, and severe pneumonia: a meta-analysis of randomized controlled trials
    Francois Lamontagne
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 25:420-35. 2010
    ..We sought to determine whether systemic corticosteroids reduce hospital mortality from these illnesses...
  52. ncbi request reprint Anticoagulant prophylaxis to prevent asymptomatic deep vein thrombosis in hospitalized medical patients: a systematic review and meta-analysis
    N S Lloyd
    Department of Medicine, McMaster University, and St Joseph s Healthcare, Hamilton, ON, Canada
    J Thromb Haemost 6:405-14. 2008
    ..We conducted a systematic review to determine whether anticoagulant prophylaxis reduces the risk of asymptomatic DVT compared to no prophylaxis in at-risk hospitalized medical patients...
  53. doi request reprint Irbesartan in patients with atrial fibrillation
    Salim Yusuf
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    N Engl J Med 364:928-38. 2011
    ..The risk of cardiovascular events among patients with atrial fibrillation is high. We evaluated whether irbesartan, an angiotensin-receptor blocker, would reduce this risk...
  54. ncbi request reprint Clinical impact of bleeding in patients taking oral anticoagulant therapy for venous thromboembolism: a meta-analysis
    Lori Ann Linkins
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 139:893-900. 2003
    ..Clinicians should consider the clinical impact of anticoagulant-related bleeding when deciding on the duration of anticoagulant therapy in patients with venous thromboembolism...
  55. ncbi request reprint Patient preferences for capillary vs. venous INR determination in an anticoagulation clinic: a randomized controlled trial
    Karen Woods
    Department of Medicine, McMaster University, Room F 541, 50 Charlton Avenue East, Hamilton, ON, Canada L8N 4A6
    Thromb Res 114:161-5. 2004
    ..Although previous studies suggest that capillary blood monitoring of the international normalize ratio (INR) is rapid and reliable, patient preferences for the method of blood drawing have not been investigated...
  56. ncbi request reprint Meta-analysis: anticoagulant prophylaxis to prevent symptomatic venous thromboembolism in hospitalized medical patients
    Francesco Dentali
    McMaster University and St Joseph s Healthcare, Hamilton, Ontario, Canada
    Ann Intern Med 146:278-88. 2007
    ..Underutilization of anticoagulant prophylaxis may be due to lack of evidence that prophylaxis prevents clinically important outcomes in hospitalized medical patients at risk for venous thromboembolism...
  57. ncbi request reprint Combined aspirin-oral anticoagulant therapy compared with oral anticoagulant therapy alone among patients at risk for cardiovascular disease: a meta-analysis of randomized trials
    Francesco Dentali
    Department of Medicine, McMaster University, and St Joseph s Healthcare, Hamilton, Ontario, Canada
    Arch Intern Med 167:117-24. 2007
    ..We performed a systematic review and meta-analysis of randomized controlled trials comparing these 2 treatment strategies (combined aspirin-OAC therapy vs OAC therapy alone) to assess the therapeutic benefits and risks...
  58. doi request reprint Research ethics board approval for an international thromboprophylaxis trial
    Kristina Lutz
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    J Crit Care 27:225-31. 2012
    ..The objectives of this study were to examine the time from submission to approval, to analyze predictors of approval time, and to describe the scope of conditions from REBs evaluating an international thromboprophylaxis trial...
  59. ncbi request reprint Semiquantitative dipyridamole myocardial stress perfusion imaging for cardiac risk assessment before noncardiac vascular surgery: a meta-analysis
    Edward Etchells
    Division of General Internal Medicine at Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    J Vasc Surg 36:534-40. 2002
    ..Semiquantitative dipyridamole myocardial perfusion scintigraphy may provide better estimates of perioperative cardiac risk than nonquantitative scintigraphy...
  60. ncbi request reprint Does the location of thrombosis determine the risk of disease recurrence in patients with proximal deep vein thrombosis?
    J D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Med 110:515-9. 2001
    ..To determine if the location of deep vein thrombosis is a predictor of recurrent venous thromboembolism during the initial 3 months of anticoagulant therapy...
  61. ncbi request reprint A meta-analysis comparing low-molecular-weight heparins with unfractionated heparin in the treatment of venous thromboembolism: examining some unanswered questions regarding location of treatment, product type, and dosing frequency
    L R Dolovich
    Centre for Evaluation of Medicines, Department of Pharmacy, St Joseph s Hospital, Hamilton, Ontario, Canada
    Arch Intern Med 160:181-8. 2000
    ....
  62. ncbi request reprint The effects of low-intensity warfarin on coagulation activation in patients with antiphospholipid antibodies and systemic lupus erythematosus
    J D Douketis
    Department of Medicine, McMaster University, Hamilton, Canada
    Thromb Haemost 82:1028-32. 1999
    ..0 to 2.5, is effective in suppressing coagulation activation, and therefore, might be effective in preventing thromboembolism...
  63. ncbi request reprint Treatment of warfarin-associated coagulopathy: a physician survey
    S E Wilson
    St. Joseph's Hospital, Hamilton, Ontario, Canada
    Chest 120:1972-6. 2001
    ..These findings highlight the need for randomized controlled trials to compare the efficacy of different routes of administration of vitamin K for warfarin-associated coagulopathy...
  64. ncbi request reprint Low-dose oral vitamin K to normalize the international normalized ratio prior to surgery in patients who require temporary interruption of warfarin
    Karen Woods
    Department of Medicine, McMaster University and St Joseph s Healthcare, Room F 544, 50 Charlton Ave East, Hamilton, ON, Canada L8N 4A6
    J Thromb Thrombolysis 24:93-7. 2007
    ..In patients who require warfarin interruption before surgery and have an elevated international normalized ratio (INR) before surgery, low-dose vitamin K may normalize the INR in time for surgery...
  65. ncbi request reprint Obesity and cardiovascular disease: pathogenic mechanisms and potential benefits of weight reduction
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Semin Vasc Med 5:25-33. 2005
    ....
  66. ncbi request reprint The perioperative management of antithrombotic therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    James D Douketis
    McMaster University, Hamilton, Ontario, Canada
    Chest 133:299S-339S. 2008
    ....
  67. doi request reprint Event adjudication and data monitoring in an intensive care unit observational study of thromboprophylaxis
    D Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 24:168-75. 2009
    ....
  68. doi request reprint Perioperative anticoagulation in patients having implantation of a cardiac pacemaker or defibrillator: a systematic review and practical management guide
    E Jamula
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    J Thromb Haemost 6:1615-21. 2008
    ..The perioperative management of anticoagulation in patients who are having implantation of a pacemaker or implantable cardioverter defibrillator (ICD) is a common clinical problem in which best clinical practise is not established...
  69. pmc Periodic health examination, 1999 update: 1. Detection, prevention and treatment of obesity. Canadian Task Force on Preventive Health Care
    J D Douketis
    CMAJ 160:513-25. 1999
    ....
  70. ncbi request reprint Systematic overview of warfarin and its drug and food interactions
    Anne M Holbrook
    Centre for Evaluation of Medicines, St Joseph s Healthcare, Hamilton, Ontario
    Arch Intern Med 165:1095-106. 2005
    ..Drug and food interactions are frequently cited as causes of adverse events with warfarin. We provide an updated systematic overview of the quality, clinical effect, and importance of these reported interactions...
  71. ncbi request reprint Oral vitamin K lowers the international normalized ratio more rapidly than subcutaneous vitamin K in the treatment of warfarin-associated coagulopathy. A randomized, controlled trial
    Mark A Crowther
    St Joseph s Hospital, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada
    Ann Intern Med 137:251-4. 2002
    ..Excessive anticoagulation due to warfarin use is associated with hemorrhage. Subcutaneously administered vitamin K has not been evaluated for the treatment of warfarin-associated coagulopathy, yet it is widely used...
  72. pmc Patient outcomes after deep vein thrombosis and pulmonary embolism: the Worcester Venous Thromboembolism Study
    Frederick A Spencer
    Department of Medicine, McMaster University, Faculty of Health Sciences and Blood Institute, Hamilton, ON, Canada
    Arch Intern Med 168:425-30. 2008
    ..The purpose of this study was to measure and compare clinical characteristics and outcomes of patients with validated symptomatic PE and isolated DVT in a New England community...
  73. ncbi request reprint A framework for resolving disagreement during end of life care in the critical care unit
    Karen Choong
    Department of Pediatrics and Critical Care, McMaster Children s Hospital, McMaster University, Hamilton, Ontario
    Clin Invest Med 33:E240-53. 2010
    ..Such disagreements can cause tension and moral distress among families and clinicians...
  74. ncbi request reprint Weaning critically ill adults from invasive mechanical ventilation: a national survey
    Karen E A Burns
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada
    Can J Anaesth 56:567-76. 2009
    ..To determine the stated practices of clinicians in weaning critically ill adults from invasive ventilation...
  75. ncbi request reprint Dental surgery for patients on anticoagulant therapy with warfarin: a systematic review and meta-analysis
    Adeela Nematullah
    University of Toronto, Ontario, Canada
    J Can Dent Assoc 75:41. 2009
    ..To evaluate the effect of continuing warfarin therapy on the bleeding risk of patients undergoing elective dental surgical procedures...
  76. ncbi request reprint Low-molecular-weight heparins for the treatment of acute coronary syndrome and venous thromboembolism in patients with chronic renal insufficiency
    Wendy Lim
    Department of Medicine, McMaster University and St Joseph s Hospital, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
    Thromb Res 118:409-16. 2006
    ....
  77. doi request reprint Comparison of pain and ecchymosis with low-molecular-weight heparin vs. unfractionated heparin in patients requiring bridging anticoagulation after warfarin interruption: a randomized trial
    Erin Jamula
    Department of Medicine, McMaster University, Hamilton, Canada
    J Thromb Thrombolysis 28:266-8. 2009
    ..Although LMWH and UFH are self-administered by >90% of patients, factors that may be important to patients such as differences in pain and ecchymosis have not been explored...
  78. ncbi request reprint Systematic review: D-dimer to predict recurrent disease after stopping anticoagulant therapy for unprovoked venous thromboembolism
    Madeleine Verhovsek
    McMaster University and St Joseph s Hospital, Hamilton, Ontario, Canada
    Ann Intern Med 149:481-90, W94. 2008
    ..Methods for predicting risk for recurrence may identify low-risk patients who are less likely to benefit from prolonged anticoagulation...
  79. ncbi request reprint Management of hypertension in overweight and obese patients: a practical guide for clinicians
    Francesco Dentali
    St Joseph s Hospital, Room F 541, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
    Curr Hypertens Rep 7:330-6. 2005
    ..Additional studies to further clarify the management of these patients are warranted...
  80. ncbi request reprint Does celecoxib potentiate the anticoagulant effect of warfarin? A randomized, double-blind, controlled trial
    Francesco Dentali
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Ann Pharmacother 40:1241-7. 2006
    ..Cyclooxygenase-2 selective NSAIDs such as celecoxib may be less likely to promote gastrointestinal bleeding; however, there are concerns that they could potentiate the anticoagulation effect of warfarin...
  81. ncbi request reprint Dosing practices and risk factors for bleeding in patients receiving enoxaparin for the treatment of an acute coronary syndrome
    Christine Macie
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Chest 125:1616-21. 2004
    ..To describe dosing practices and to identify risk factors for bleeding in patients with an acute coronary syndrome (ACS) who received treatment with enoxaparin...
  82. doi request reprint Safety of uninterrupted anticoagulation in patients requiring elective coronary angiography with or without percutaneous coronary intervention: a systematic review and metaanalysis
    Erin Jamula
    Department of Medicine, McMaster University and St Joseph s Healthcare, Hamilton, ON, Canada
    Chest 138:840-7. 2010
    ..However, it may be possible to safely perform some procedures, such as coronary angiography with or without percutaneous coronary intervention (PCI), without VKA interruption...
  83. doi request reprint Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis
    Matthias Briel
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    JAMA 303:865-73. 2010
    ....
  84. ncbi request reprint Are brand-name and generic warfarin interchangeable? A survey of Ontario patients and physicians
    Jennifer A Pereira
    Centre for Evaluation of Medicines, St Joseph s Healthcare, Hamilton, ON
    Can J Clin Pharmacol 12:e229-39. 2005
    ..The issue of therapeutic equivalence has been a source of controversy in Canada since the approval of generic warfarin products in 2000...
  85. pmc Canadian guidelines for body weight classification in adults: application in clinical practice to screen for overweight and obesity and to assess disease risk
    James D Douketis
    St Joseph s Hospital and Department of Medicine, McMaster University, Hamilton, Ont
    CMAJ 172:995-8. 2005
  86. ncbi request reprint Are brand-name and generic warfarin interchangeable? Multiple n-of-1 randomized, crossover trials
    Jennifer A Pereira
    Centre for Evaluation of Medicines, St Joseph s Healthcare, Hamilton, Ontario, Canada
    Ann Pharmacother 39:1188-93. 2005
    ..Warfarin is a commonly used anticoagulant in North America. Several generic formulations have been approved, raising concern over the safety and efficacy of these products compared with brand-name Coumadin...
  87. doi request reprint Safety of continuing warfarin therapy during cataract surgery: a systematic review and meta-analysis
    Erin Jamula
    Department of Medicine, McMaster University and St Joseph s Healthcare, Hamilton, ON, Canada
    Thromb Res 124:292-9. 2009
    ..In patients who are receiving warfarin therapy and require cataract surgery, it may be possible to continue warfarin in the perioperative period but the safety of this management strategy has not been systematically evaluated...
  88. ncbi request reprint Randomized trial of combination versus monotherapy for the empiric treatment of suspected ventilator-associated pneumonia
    Daren K Heyland
    Kingston General Hospital and Queen s University, Kingston, ON, Canada
    Crit Care Med 36:737-44. 2008
    ..To compare a strategy of combination therapy with a strategy of monotherapy with broad-spectrum antibiotics for suspected late ventilator-associated pneumonia...
  89. ncbi request reprint Acute renal vein thrombosis, oral contraceptive use, and hyperhomocysteinemia
    H H Chan
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Mayo Clin Proc 76:212-4. 2001
    ..In oral contraceptive users who develop venous thrombosis in the absence of other risk factors, clinicians should consider investigations for an underlying prothrombotic biochemical disorder...
  90. doi request reprint Periprocedural anticoagulation practices in warfarin-treated patients who require elective angiography with or without percutaneous coronary intervention: a retrospective chart review
    Erin Jamula
    Department of Medicine, McMaster University and St Joseph s Healthcare, Hamilton ON, Canada
    Thromb Res 125:351-2. 2010
    ..However, before further high quality research can be performed in this area, information such as current practice and associated event rates is required...
  91. ncbi request reprint Incidence of Smith-Lemli-Opitz syndrome in Canada: results of three-year population surveillance
    Małgorzata J M Nowaczyk
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    J Pediatr 145:530-5. 2004
    ..SLOS is a treatable genetic condition that may be difficult to diagnose in its mildest form because of nonspecific clinical markers (two- to three-toe webbing, short upturned nose, and micrognathia)...
  92. ncbi request reprint Influence of warfarin on symptoms of fatigue: findings of a randomized trial
    Michael J Kovacs
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Ann Pharmacother 39:840-2. 2005
    ..Some patients develop fatigue while taking warfarin, but causality is uncertain...
  93. ncbi request reprint DHCR7 mutation carrier rates and prevalence of the RSH/Smith-Lemli-Opitz syndrome: where are the patients?
    Małgorzata J M Nowaczyk
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
    Am J Med Genet A 140:2057-62. 2006
    ..In order to reconcile the above-mentioned paradoxes, we propose a model based on a higher than observed carrier frequency of the most common mutation and on very high fetal loss of homozygotes for that mutation...
  94. ncbi request reprint Prevention and treatment of hormone-associated venous thromboembolism: a patient management approach
    Joanna Ueng
    Department of Medicine, St Joseph s Healthcare Hamilton, McMaster University, Hamilton, ON, Canada
    Hematol Oncol Clin North Am 24:683-94, vii-viii. 2010
    ....
  95. doi request reprint Perioperative management of warfarin therapy: to bridge or not to bridge, that is the question
    James D Douketis
    Mayo Clin Proc 83:628-9. 2008
  96. ncbi request reprint Oral vitamin K produces a normal INR within 24 hours of its administration in most patients discontinuing warfarin
    Mark A Crowther
    Haematologica 90:137-9. 2005
    ..Larger studies will be required to determine if the use of oral vitamin K, for example in patients who are temporarily discontinuing warfarin to undergo interventional procedures, is safe and effective...
  97. pmc Body weight classification
    James D Douketis
    CMAJ 172:1274-5; author reply 1275. 2005
  98. pmc 2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary]
    David C W Lau
    Department of Medicine, Julia McFarlane Diabetes Research Centre, Diabetes and Endocrine Research Group, University of Calgary, Calgary, Alta
    CMAJ 176:S1-13. 2007
  99. ncbi request reprint Are heparins anti-neoplastic agents?
    James D Douketis
    Pol Arch Med Wewn 117:491-3. 2007
  100. ncbi request reprint Why A-level evidence does not make it to clinicians' A-lists: the case of thromboprophylaxis in medical patients
    James D Douketis
    ACP J Club 149:2. 2008
  101. ncbi request reprint Use of a clinical prediction score in patients with suspected deep venous thrombosis: two steps forward, one step back?
    James D Douketis
    Ann Intern Med 143:140-2. 2005