M O Meade

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. doi request reprint Clinical trial design in acute lung injury--issues and controversies
    Maureen O Meade
    Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, Health Sciences Centre, 1280 Main Street West, Hamilton, Ontario, Canada
    Semin Respir Crit Care Med 34:516-21. 2013
  2. pmc Red blood cell transfusion and increased length of storage are not associated with deep vein thrombosis in medical and surgical critically ill patients: a prospective observational cohort study
    Christina Katsios
    Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, ON L8S 4L8, Canada
    Crit Care 15:R263. 2011
  3. pmc Wean Earlier and Automatically with New technology (the WEAN study): a protocol of a multicentre, pilot randomized controlled trial
    Karen E A Burns
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada
    Trials 10:81. 2009
  4. pmc Clinical review: Intra-abdominal hypertension: does it influence the physiology of prone ventilation?
    Andrew W Kirkpatrick
    Regional Trauma Services, Foothills Medical Centre, 1403 29 Street NW, Calgary, Alberta, Canada
    Crit Care 14:232. 2010
  5. pmc Drotrecogin alfa (activated): down and not out, but not really in either
    Jan O Friedrich
    Crit Care 10:420. 2006
  6. pmc Drotrecogin alfa (activated) in patients with severe sepsis and a high risk of death
    Jan O Friedrich
    Crit Care 10:427. 2006
  7. pmc Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Pro: Futility stopping can speed up the development of effective treatments
    David A Schoenfeld
    Department of Biostatistics, Harvard School of Public Health, Massachusetts General Hospital, Boston, Massachusetts, USA
    Crit Care 9:34-6; discussion 34-6. 2005
  8. ncbi request reprint Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Con: the hazards of stopping for futility
    Maureen O Meade
    Department of Medicine and Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Crit Care 9:34-6; discussion 34-6. 2005
  9. doi request reprint Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial
    Maureen O Meade
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    JAMA 299:637-45. 2008
  10. ncbi request reprint A study of the physiologic responses to a lung recruitment maneuver in acute lung injury and acute respiratory distress syndrome
    Maureen O Meade
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Respir Care 53:1441-9. 2008

Collaborators

Detail Information

Publications28

  1. doi request reprint Clinical trial design in acute lung injury--issues and controversies
    Maureen O Meade
    Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, Health Sciences Centre, 1280 Main Street West, Hamilton, Ontario, Canada
    Semin Respir Crit Care Med 34:516-21. 2013
    ..The third section discusses the quest for ideal Study Outcomes. The final section presents Interpretation Controversies, such as early stopping of clinical trials. ..
  2. pmc Red blood cell transfusion and increased length of storage are not associated with deep vein thrombosis in medical and surgical critically ill patients: a prospective observational cohort study
    Christina Katsios
    Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, ON L8S 4L8, Canada
    Crit Care 15:R263. 2011
    ..The objective of this study was to determine if RBC transfusions or RBC storage age predicts incident DVT in medical or surgical intensive care unit (ICU) patients...
  3. pmc Wean Earlier and Automatically with New technology (the WEAN study): a protocol of a multicentre, pilot randomized controlled trial
    Karen E A Burns
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada
    Trials 10:81. 2009
    ..Automated Weaning holds promise as a strategy to reduce the time spent on the ventilator, decrease ICU length of stay, and improve clinically important outcomes...
  4. pmc Clinical review: Intra-abdominal hypertension: does it influence the physiology of prone ventilation?
    Andrew W Kirkpatrick
    Regional Trauma Services, Foothills Medical Centre, 1403 29 Street NW, Calgary, Alberta, Canada
    Crit Care 14:232. 2010
    ..Theories relating inter-relations between prone positioning and the abdominal condition are presented to aid in designing these studies...
  5. pmc Drotrecogin alfa (activated): down and not out, but not really in either
    Jan O Friedrich
    Crit Care 10:420. 2006
  6. pmc Drotrecogin alfa (activated) in patients with severe sepsis and a high risk of death
    Jan O Friedrich
    Crit Care 10:427. 2006
  7. pmc Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Pro: Futility stopping can speed up the development of effective treatments
    David A Schoenfeld
    Department of Biostatistics, Harvard School of Public Health, Massachusetts General Hospital, Boston, Massachusetts, USA
    Crit Care 9:34-6; discussion 34-6. 2005
    ..For bedside clinicians the idea of futility in a clinical trial can be confusing. In the present article, two experts in the conduct of clinical trials debate the role of futility-stopping rules...
  8. ncbi request reprint Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Con: the hazards of stopping for futility
    Maureen O Meade
    Department of Medicine and Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Crit Care 9:34-6; discussion 34-6. 2005
  9. doi request reprint Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial
    Maureen O Meade
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    JAMA 299:637-45. 2008
    ..Low-tidal-volume ventilation reduces mortality in critically ill patients with acute lung injury and acute respiratory distress syndrome. Instituting additional strategies to open collapsed lung tissue may further reduce mortality...
  10. ncbi request reprint A study of the physiologic responses to a lung recruitment maneuver in acute lung injury and acute respiratory distress syndrome
    Maureen O Meade
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Respir Care 53:1441-9. 2008
    ..To determine the magnitude, duration, and consistency of the effects of lung recruitment maneuvers (RMs) on oxygenation, lung mechanics, and comfort in patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)...
  11. ncbi request reprint An evidence-based approach to acute respiratory distress syndrome
    M O Meade
    Department of Medicine and the Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Respir Care 46:1368-76; discussion 1376-9. 2001
    ..Ongoing research may suggest interventions to improve the outcome of ARDS and of critical illness in general...
  12. ncbi request reprint Weaning from mechanical ventilation: the evidence from clinical research
    M O Meade
    Department of Medicine and the Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Respir Care 46:1408-15; discussion 1415-7. 2001
    ....
  13. ncbi request reprint Trials of corticosteroids to prevent postextubation airway complications
    M O Meade
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Chest 120:464S-8S. 2001
    ..However, the effect of corticosteroids in children and adults to reduce postextubation complications such as reintubation is uncertain...
  14. pmc The attributable mortality and length of intensive care unit stay of clinically important gastrointestinal bleeding in critically ill patients
    D J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care 5:368-75. 2001
    ..To estimate the mortality and length of stay in the intensive care unit (ICU) attributable to clinically important gastrointestinal bleeding in mechanically ventilated critically ill patients...
  15. ncbi request reprint Agreement between alternative classifications of acute respiratory distress syndrome
    M O Meade
    Department of Medicine, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 163:490-3. 2001
    ..These discordant classifications had no prognostic importance...
  16. ncbi request reprint Qualitative studies on the patient's experience of weaning from mechanical ventilation
    D J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Chest 120:469S-73S. 2001
    ....
  17. ncbi request reprint Dalteparin thromboprophylaxis for critically ill medical-surgical patients with renal insufficiency
    Christian G Rabbat
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:357-63. 2005
    ....
  18. ncbi request reprint Trials comparing early vs late extubation following cardiovascular surgery
    M O Meade
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Chest 120:445S-53S. 2001
    ....
  19. ncbi request reprint Clinical estimation of trunk position among mechanically ventilated patients
    J P McMullin
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Intensive Care Med 28:304-9. 2002
    ..The objectives of this study were to determine the accuracy of trunk flexion estimates compared to a reference standard measurement, and to determine agreement about trunk flexion among ICU clinicians...
  20. ncbi request reprint High values of the pulmonary artery wedge pressure in patients with acute lung injury and acute respiratory distress syndrome
    Niall D Ferguson
    Department of Medicine, Division of Respirology, Critical Care Medicine Program, Mount Sinai Hospital, 600 University Avenue, University of Toronto, Toronto, Ontario, Canada
    Intensive Care Med 28:1073-7. 2002
    ..In addition, to examine the effects of clinical variables on the presence of a high PAWP (>18 mmHg) and the effect of an elevated PAWP on mortality...
  21. doi request reprint Enrollment of intensive care unit patients into clinical studies: a trinational survey of researchers' experiences, beliefs, and practices
    Deborah J Cook
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Crit Care Med 36:2100-5. 2008
    ..As critical care practice increases in scope, size, and complexity, enrollment of critically ill patients into clinical studies is increasing...
  22. ncbi request reprint Survey of interventions for the prevention and treatment of acute respiratory distress syndrome
    Maureen O Meade
    Clinical Epidemiology and Biostatistics, and Medicine, McMaster University Health Sciences Centre, Hamilton, ON, Canada
    Crit Care Med 32:946-54. 2004
    ..To determine physicians' opinions and practices related to the management of patients with acute respiratory distress syndrome...
  23. ncbi request reprint Evolution of mechanical ventilation in response to clinical research
    Andres Esteban
    Intensive Care Unit, Hospital Universitario de Getafe, Carretera de Toledo Km 12, 500, 28905 Getafe, Madrid, Spain
    Am J Respir Crit Care Med 177:170-7. 2008
    ..Recent literature in mechanical ventilation includes strong evidence from randomized trials. Little information is available regarding the influence of these trials on usual clinical practice...
  24. ncbi request reprint A multicenter survey of Ontario intensive care unit nurses regarding the use of sedatives and analgesics for adults receiving mechanical ventilation
    Sangeeta Mehta
    University of Toronto, Toronto, Ontario, Canada M5G 1X5
    J Crit Care 22:191-6. 2007
    ..Nursing-directed sedation protocols have been shown to reduce the duration of mechanical ventilation and shorten the length of intensive care unit (ICU) stay among critically ill adult patients...
  25. pmc Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis
    Neill K J Adhikari
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada
    BMJ 334:779. 2007
    ....
  26. ncbi request reprint Pharmacologic treatments for acute respiratory distress syndrome and acute lung injury: systematic review and meta-analysis
    Neill Adhikari
    Department of Critical Care Medicine, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Treat Respir Med 3:307-28. 2004
    ..Our objective was to systematically evaluate this literature to determine the effects of these interventions on important clinical outcomes...
  27. ncbi request reprint Bilevel noninvasive positive pressure ventilation for acute respiratory failure: survey of Ontario practice
    Karen E A Burns
    Division of Critical Care Medicine, University of Western Ontario, London, Ontario, Canada
    Crit Care Med 33:1477-83. 2005
    ..To determine physicians' stated practices regarding the use of bilevel noninvasive ventilation (NIV) for acute respiratory failure and the predictors of practice variation...
  28. ncbi request reprint A meta-analysis of noninvasive weaning to facilitate liberation from mechanical ventilation
    Karen E A Burns
    Division of Critical Care Medicine, London Health Sciences Centre Victoria Hospital
    Can J Anaesth 53:305-15. 2006
    ....