Research Topics
| M O MeadeSummaryAffiliation: McMaster University Country: Canada Publications
| Collaborators
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Detail Information
Publications
Red blood cell transfusion and increased length of storage are not associated with deep vein thrombosis in medical and surgical critically ill patients: a prospective observational cohort studyChristina Katsios
Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, ON L8S 4L8, Canada
Crit Care 15:R263. 2011..The objective of this study was to determine if RBC transfusions or RBC storage age predicts incident DVT in medical or surgical intensive care unit (ICU) patients...- Wean Earlier and Automatically with New technology (the WEAN study): a protocol of a multicentre, pilot randomized controlled trialKaren E A Burns
Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada
Trials 10:81. 2009..Automated Weaning holds promise as a strategy to reduce the time spent on the ventilator, decrease ICU length of stay, and improve clinically important outcomes... - Clinical review: Intra-abdominal hypertension: does it influence the physiology of prone ventilation?Andrew W Kirkpatrick
Regional Trauma Services, Foothills Medical Centre, 1403 29 Street NW, Calgary, Alberta, Canada
Crit Care 14:232. 2010..Theories relating inter-relations between prone positioning and the abdominal condition are presented to aid in designing these studies... - Drotrecogin alfa (activated): down and not out, but not really in eitherJan O Friedrich
Crit Care 10:420. 2006 - Drotrecogin alfa (activated) in patients with severe sepsis and a high risk of deathJan O Friedrich
Crit Care 10:427. 2006 - Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Pro: Futility stopping can speed up the development of effective treatmentsDavid A Schoenfeld
Department of Biostatistics, Harvard School of Public Health, Massachusetts General Hospital, Boston, Massachusetts, USA
Crit Care 9:34-6; discussion 34-6. 2005..For bedside clinicians the idea of futility in a clinical trial can be confusing. In the present article, two experts in the conduct of clinical trials debate the role of futility-stopping rules... 
Weaning from mechanical ventilation: the evidence from clinical researchM O Meade
Department of Medicine and the Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
Respir Care 46:1408-15; discussion 1415-7. 2001....
Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trialMaureen O Meade
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
JAMA 299:637-45. 2008..Low-tidal-volume ventilation reduces mortality in critically ill patients with acute lung injury and acute respiratory distress syndrome. Instituting additional strategies to open collapsed lung tissue may further reduce mortality...- A study of the physiologic responses to a lung recruitment maneuver in acute lung injury and acute respiratory distress syndromeMaureen O Meade
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Respir Care 53:1441-9. 2008..To determine the magnitude, duration, and consistency of the effects of lung recruitment maneuvers (RMs) on oxygenation, lung mechanics, and comfort in patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)... - An evidence-based approach to acute respiratory distress syndromeM O Meade
Department of Medicine and the Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
Respir Care 46:1368-76; discussion 1376-9. 2001..Ongoing research may suggest interventions to improve the outcome of ARDS and of critical illness in general... - Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Con: the hazards of stopping for futilityMaureen O Meade
Department of Medicine and Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
Crit Care 9:34-6; discussion 34-6. 2005 - Trials of corticosteroids to prevent postextubation airway complicationsM O Meade
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Chest 120:464S-8S. 2001..However, the effect of corticosteroids in children and adults to reduce postextubation complications such as reintubation is uncertain... - The attributable mortality and length of intensive care unit stay of clinically important gastrointestinal bleeding in critically ill patientsD J Cook
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Crit Care 5:368-75. 2001..To estimate the mortality and length of stay in the intensive care unit (ICU) attributable to clinically important gastrointestinal bleeding in mechanically ventilated critically ill patients... - Agreement between alternative classifications of acute respiratory distress syndromeM O Meade
Department of Medicine, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada
Am J Respir Crit Care Med 163:490-3. 2001..These discordant classifications had no prognostic importance... - Qualitative studies on the patient's experience of weaning from mechanical ventilationD J Cook
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Chest 120:469S-73S. 2001.... - Dalteparin thromboprophylaxis for critically ill medical-surgical patients with renal insufficiencyChristian G Rabbat
Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
J Crit Care 20:357-63. 2005..If dalteparin does not bioaccumulate, it may be an attractive alternative agent for thromboprophylaxis... - Trials comparing early vs late extubation following cardiovascular surgeryM O Meade
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Chest 120:445S-53S. 2001.... - Clinical estimation of trunk position among mechanically ventilated patientsJ P McMullin
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Intensive Care Med 28:304-9. 2002.... - Enrollment of intensive care unit patients into clinical studies: a trinational survey of researchers' experiences, beliefs, and practicesDeborah J Cook
Department of Medicine, McMaster University, Hamilton, ON, Canada
Crit Care Med 36:2100-5. 2008..As critical care practice increases in scope, size, and complexity, enrollment of critically ill patients into clinical studies is increasing... - High values of the pulmonary artery wedge pressure in patients with acute lung injury and acute respiratory distress syndromeNiall D Ferguson
Department of Medicine, Division of Respirology, Critical Care Medicine Program, Mount Sinai Hospital, 600 University Avenue, University of Toronto, Toronto, Ontario, Canada
Intensive Care Med 28:1073-7. 2002..81). CONCLUSIONS: We conclude that in this group of patients a PAWP higher than 18 mmHg is common. Mandating a PAWP of 18 mmHg or less may negatively impact clinical trials in which ARDS is an inclusion/exclusion criteria or an endpoint... - Evolution of mechanical ventilation in response to clinical researchAndres Esteban
Intensive Care Unit, Hospital Universitario de Getafe, Carretera de Toledo Km 12, 500, 28905 Getafe, Madrid, Spain
Am J Respir Crit Care Med 177:170-7. 2008..Recent literature in mechanical ventilation includes strong evidence from randomized trials. Little information is available regarding the influence of these trials on usual clinical practice... - A multicenter survey of Ontario intensive care unit nurses regarding the use of sedatives and analgesics for adults receiving mechanical ventilationSangeeta Mehta
University of Toronto, Toronto, Ontario, Canada M5G 1X5
J Crit Care 22:191-6. 2007..Nursing-directed sedation protocols have been shown to reduce the duration of mechanical ventilation and shorten the length of intensive care unit (ICU) stay among critically ill adult patients... - Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysisNeill K J Adhikari
Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada
BMJ 334:779. 2007.... - Survey of interventions for the prevention and treatment of acute respiratory distress syndromeMaureen O Meade
Clinical Epidemiology and Biostatistics, and Medicine, McMaster University Health Sciences Centre, Hamilton, ON, Canada
Crit Care Med 32:946-54. 2004.... - Pharmacologic treatments for acute respiratory distress syndrome and acute lung injury: systematic review and meta-analysisNeill Adhikari
Department of Critical Care Medicine, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
Treat Respir Med 3:307-28. 2004..Our objective was to systematically evaluate this literature to determine the effects of these interventions on important clinical outcomes... - A meta-analysis of noninvasive weaning to facilitate liberation from mechanical ventilationKaren E A Burns
Division of Critical Care Medicine, London Health Sciences Centre Victoria Hospital
Can J Anaesth 53:305-15. 2006.... - Bilevel noninvasive positive pressure ventilation for acute respiratory failure: survey of Ontario practiceKaren E A Burns
Division of Critical Care Medicine, University of Western Ontario, London, Ontario, Canada
Crit Care Med 33:1477-83. 2005..Some factors associated with variation in NIV use may be suitable targets for utilization improvement interventions...