Robert S McKelvie

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint Exercise training in patients with heart failure: clinical outcomes, safety, and indications
    Robert S McKelvie
    Hamilton Health Sciences Corporation General Site, 237 Barton Street East, L8L 2X2, Hamilton, ON, Canada
    Heart Fail Rev 13:3-11. 2008
  2. ncbi request reprint Candesartan for the management of heart failure: more than an alternative
    Robert S McKelvie
    HHSC General Division, 237 Barton Street East, Hamilton, Ontario, L8L 2X2, Canada
    Expert Opin Pharmacother 7:1945-56. 2006
  3. ncbi request reprint Initial data supporting the design of the Candesartan in Heart failure--assessment of reduction in mortality and morbidity (CHARM) programme
    Robert S McKelvie
    HHSC General Division, Hamilton, Ontario, Canada
    J Hypertens Suppl 24:S9-13. 2006
  4. doi request reprint The CHARM program: the effects of candesartan for the management of patients with chronic heart failure
    Robert S McKelvie
    HHSC General Division, Ontario, Canada
    Expert Rev Cardiovasc Ther 7:9-16. 2009
  5. ncbi request reprint The therapeutic potential of angiotensin II receptor blockers in the treatment of heart failure
    Robert S McKelvie
    Hamilton Health Sciences, Ontario, Canada
    Expert Opin Investig Drugs 13:245-53. 2004
  6. ncbi request reprint Comparative impact of enalapril, candesartan or metoprolol alone or in combination on ventricular remodelling in patients with congestive heart failure
    Robert S McKelvie
    Hamilton Health Sciences, General Division, Ontario, Hamilton, Canada
    Eur Heart J 24:1727-34. 2003
  7. ncbi request reprint Usefulness of temporal changes in neurohormones as markers of ventricular remodeling and prognosis in patients with left ventricular systolic dysfunction and heart failure receiving either candesartan or enalapril or both
    Raymond T Yan
    The University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 96:698-704. 2005
  8. ncbi request reprint Digoxin prescribing for heart failure in elderly residents of long-term care facilities
    Brian Misiaszek
    Hamilton General Hospital, McMaster Clinic, Hamilton, Canada
    Can J Cardiol 21:281-6. 2005
  9. ncbi request reprint Impact of candesartan on nonfatal myocardial infarction and cardiovascular death in patients with heart failure
    Catherine Demers
    McMaster University, Hamilton, Ontario, Canada
    JAMA 294:1794-8. 2005
  10. doi request reprint The 2012 Canadian Cardiovascular Society heart failure management guidelines update: focus on acute and chronic heart failure
    Robert S McKelvie
    Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Can J Cardiol 29:168-81. 2013

Detail Information

Publications50

  1. ncbi request reprint Exercise training in patients with heart failure: clinical outcomes, safety, and indications
    Robert S McKelvie
    Hamilton Health Sciences Corporation General Site, 237 Barton Street East, L8L 2X2, Hamilton, ON, Canada
    Heart Fail Rev 13:3-11. 2008
    ..This article reviews the effects of exercise training on clinical outcomes and addressing the safety of exercise training and the indications for training in HF patients...
  2. ncbi request reprint Candesartan for the management of heart failure: more than an alternative
    Robert S McKelvie
    HHSC General Division, 237 Barton Street East, Hamilton, Ontario, L8L 2X2, Canada
    Expert Opin Pharmacother 7:1945-56. 2006
    ..This paper will review the data supporting the use of candesartan to treat all heart failure patients, regardless of their ejection fraction...
  3. ncbi request reprint Initial data supporting the design of the Candesartan in Heart failure--assessment of reduction in mortality and morbidity (CHARM) programme
    Robert S McKelvie
    HHSC General Division, Hamilton, Ontario, Canada
    J Hypertens Suppl 24:S9-13. 2006
    ..The use of angiotensin II receptor blockers may provide a means of fulfilling these needs...
  4. doi request reprint The CHARM program: the effects of candesartan for the management of patients with chronic heart failure
    Robert S McKelvie
    HHSC General Division, Ontario, Canada
    Expert Rev Cardiovasc Ther 7:9-16. 2009
    ..This paper will review the data supporting the use of candesartan to treat all HF patients, regardless of their ejection fraction...
  5. ncbi request reprint The therapeutic potential of angiotensin II receptor blockers in the treatment of heart failure
    Robert S McKelvie
    Hamilton Health Sciences, Ontario, Canada
    Expert Opin Investig Drugs 13:245-53. 2004
    ..This paper reviews the data defining the role of ARBs in the treatment of HF patients, focusing more on the large randomised clinical outcome trials...
  6. ncbi request reprint Comparative impact of enalapril, candesartan or metoprolol alone or in combination on ventricular remodelling in patients with congestive heart failure
    Robert S McKelvie
    Hamilton Health Sciences, General Division, Ontario, Hamilton, Canada
    Eur Heart J 24:1727-34. 2003
    ..Patients were later randomized to metoprolol CR (M) or placebo. Examine impact of C or E (C/E), C+E, C+M/E+M, C+E+M on ventricular remodelling in heart failure (HF) over 43 weeks...
  7. ncbi request reprint Usefulness of temporal changes in neurohormones as markers of ventricular remodeling and prognosis in patients with left ventricular systolic dysfunction and heart failure receiving either candesartan or enalapril or both
    Raymond T Yan
    The University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 96:698-704. 2005
    ..Serial measurements of these neurohormones may serve as useful surrogate markers of ventricular remodeling and prognosticators for clinical risk stratification...
  8. ncbi request reprint Digoxin prescribing for heart failure in elderly residents of long-term care facilities
    Brian Misiaszek
    Hamilton General Hospital, McMaster Clinic, Hamilton, Canada
    Can J Cardiol 21:281-6. 2005
    ..This toxicity may occur at serum digoxin concentrations that are as low as 1.54 nmol/L...
  9. ncbi request reprint Impact of candesartan on nonfatal myocardial infarction and cardiovascular death in patients with heart failure
    Catherine Demers
    McMaster University, Hamilton, Ontario, Canada
    JAMA 294:1794-8. 2005
    ..Angiotensin-converting enzyme (ACE) inhibitors reduce the risk of myocardial infarction (MI), but it is not known whether angiotensin receptor blockers have the same effect...
  10. doi request reprint The 2012 Canadian Cardiovascular Society heart failure management guidelines update: focus on acute and chronic heart failure
    Robert S McKelvie
    Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Can J Cardiol 29:168-81. 2013
    ..The 2012 Update also includes recommendations, values and preferences, and practical tips to assist the medical practitioner manage their patients with HF...
  11. pmc Relationships between plasma levels of matrix metalloproteinases and neurohormonal profile in patients with heart failure
    Andrew T Yan
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Eur J Heart Fail 10:125-8. 2008
    ..There is also emerging preclinical information to suggest that these signalling pathways mutually regulate in HF...
  12. ncbi request reprint Heart failure--related mortality and hospitalization in the year following admission to a long-term care facility: the geriatric outcomes and longitudinal decline in heart failure (GOLD-HF) study
    Andrea D Foebel
    School of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario, Canada
    J Card Fail 19:468-77. 2013
    ..Heart failure (HF) is common in long-term care facilities (LTCs). This study compared mortality and hospitalization rates and examined predictors of these outcomes among new LTC residents with and without HF...
  13. ncbi request reprint Effect of aerobic vs combined aerobic-strength training on 1-year, post-cardiac rehabilitation outcomes in women after a cardiac event
    Heather M Arthur
    Department of Rehabilitation Medicine, McMaster University, Hamilton, ON, Canada
    J Rehabil Med 39:730-5. 2007
    ..To compare the effect and sustainability of 6 months combined aerobic/strength training vs aerobic training alone on quality of life in women after coronary artery by-pass graft surgery or myocardial infarction...
  14. ncbi request reprint Plasma matrix metalloproteinase-9 level is correlated with left ventricular volumes and ejection fraction in patients with heart failure
    Andrew T Yan
    Heart and Stroke Richard Lewar Centre of Excellence, Toronto, Ontario, Canada
    J Card Fail 12:514-9. 2006
    ..We hypothesized that increased plasma MMP levels correlate with increased left ventricular (LV) volumes and reduced LV ejection fraction (LVEF) in patients with HF...
  15. ncbi request reprint ACE inhibitors in heart failure: what more do we need to know?
    Catherine Demers
    Department of Medicine, Division of Cardiology, McMaster University, Hamilton, Ontario, Canada
    Am J Cardiovasc Drugs 5:351-9. 2005
    ..Although the use of ACE inhibitors may be appealing in patients with HF and preserved LV systolic function, there is currently no evidence from large clinical trials to support this...
  16. doi request reprint Usefulness of N-terminal pro-brain natriuretic Peptide and brain natriuretic peptide to predict cardiovascular outcomes in patients with heart failure and preserved left ventricular ejection fraction
    Jasmine Grewal
    Population Health Research Institute and McMaster University, Hamilton, Ontario
    Am J Cardiol 102:733-7. 2008
    ..8, p = 0.0003) as was BNP >100 pg/ml (hazard ratio 3.1, 95% CI 1.2 to 8.2, p = 0.02) in the BNP model. In conclusion, both elevated NT-proBNP and BNP are strong independent predictors of clinical events in patients with HF-PLVEF...
  17. doi request reprint The older patient with heart failure: high risk for frailty and cognitive impairment
    Karen Harkness
    Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    Expert Rev Cardiovasc Ther 10:779-95. 2012
    ..Specifically, this article describes the epidemiology of these conditions in HF patients, outlines potential underlying mechanisms, highlights relevant screening tools and reviews relevant clinical implications...
  18. doi request reprint Baseline plasma NT-proBNP and clinical characteristics: results from the irbesartan in heart failure with preserved ejection fraction trial
    Robert S McKelvie
    McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    J Card Fail 16:128-34. 2010
    ..Less is known about NT-proBNP in HF with preserved EF (HF-PEF). We measured baseline NT-proBNP in 3562 HF-PEF enrolled patients in the Irbesartan in Heart Failure with Preserved Ejection Fraction trial...
  19. ncbi request reprint Management of heart failure in Canadian long-term care facilities
    George A Heckman
    McMaster University, Hamilton, Ontario, Canada
    Can J Cardiol 20:963-9. 2004
    ..In long-term care (LTC) facilities, heart failure is common but undertreated. No Canadian studies of heart failure in LTC facilities have been reported...
  20. doi request reprint The 2011 Canadian Cardiovascular Society heart failure management guidelines update: focus on sleep apnea, renal dysfunction, mechanical circulatory support, and palliative care
    Robert S McKelvie
    Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Can J Cardiol 27:319-38. 2011
    ..Furthermore, patients awaiting heart transplantation who deteriorate or are otherwise not likely to survive until a donor organ is found should be referred for MCS...
  21. doi request reprint Predicting heart failure mortality in frail seniors: comparing the NYHA functional classification with the Resident Assessment Instrument (RAI) 2.0
    Erin Y Tjam
    St Mary s General Hospital, Kitchener, Ontario, Canada
    Int J Cardiol 155:75-80. 2012
    ..The purpose of this study was to determine whether a HF-specific prognostic model based on the RAI 2.0 is superior to the NYHA functional classification in predicting mortality in frail older HF patients...
  22. ncbi request reprint Growth hormone therapy in heart failure: where are we now?
    Catherine Demers
    Hamilton Health Sciences HHS, HHS General Division, Hamilton, Ontario, L8L 2X2 Canada
    Congest Heart Fail 9:84-90. 2003
    ..Despite the lack of benefit demonstrated in small, short-term, randomized clinical trials, further studies are needed to assess the potential role of this adjuvant therapy in heart failure patients...
  23. ncbi request reprint Exercise and the heart failure patient: aerobic vs strength training--is there a need for both?
    Elizabeth Gunn
    McMaster University, Faculty of Health Sciences, Hamilton, Ontario, Canada
    Prog Cardiovasc Nurs 21:146-50. 2006
    ..Further research is required to isolate the specific role of strength training regarding improvements in prognosis, HF-related morbidity and hospitalization, and health-related quality of life for patients with HF...
  24. ncbi request reprint The effects of exercise training on insulin resistance in patients with coronary artery disease
    Neville G Suskin
    University of Western Ontario, London, ON, Canada
    Eur J Cardiovasc Prev Rehabil 14:803-8. 2007
    ..Moreover, patients with coronary artery disease (CAD) have not been studied...
  25. ncbi request reprint Cognitive function and self-care management in older patients with heart failure
    Karen Harkness
    1McMaster University, Hamilton, Canada
    Eur J Cardiovasc Nurs 13:277-84. 2014
    ..The purpose of this study was to determine whether MCI, as identified on a simple screening tool, is significantly associated with self-care management in a sample of community dwelling older patients with heart failure...
  26. doi request reprint Screening for cognitive deficits using the Montreal cognitive assessment tool in outpatients ≥65 years of age with heart failure
    Karen Harkness
    Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Am J Cardiol 107:1203-7. 2011
    ..Future studies need to determine if the MoCA can identify the presence of CI that is predictive of adverse clinical outcomes in the HF population...
  27. ncbi request reprint The role of angiotensin II receptor blockers in the treatment of heart failure patients
    Michael Theal
    Hamilton Health Sciences Corporation General Division, McMaster University, 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada
    Congest Heart Fail 9:29-34. 2003
    ..The results from further studies are awaited to clarify the role of ARBs in the treatment of heart failure...
  28. pmc Heart failure and cognitive impairment: challenges and opportunities
    George A Heckman
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin Interv Aging 2:209-18. 2007
    ..Preliminary evidence suggests that optimal HF therapy in elderly patients may preserve or even improve cognitive function, though the impact on related outcomes remains to be determined...
  29. ncbi request reprint Differences in sustainability of exercise and health-related quality of life outcomes following home or hospital-based cardiac rehabilitation
    Kelly M Smith
    McMaster University, Faculty of Health Sciences, Hamilton, Canada
    Eur J Cardiovasc Prev Rehabil 11:313-9. 2004
    ....
  30. doi request reprint Low-volume, high-intensity interval training in patients with CAD
    Katharine D Currie
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    Med Sci Sports Exerc 45:1436-42. 2013
    ..This study compared the effects of 12-wk of HIT and higher-volume moderate-intensity endurance exercise (END) on brachial artery flow-mediated dilation (FMD) and cardiorespiratory fitness (VO2 peak) in patients with CAD...
  31. ncbi request reprint Living and dying with heart failure in long-term care: experiences of residents and their family members
    Sharon Kaasalainen
    Associate Professor, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Int J Palliat Nurs 19:375-82. 2013
    ..The findings from this study contribute to our understanding of residents' and family members' experiences in managing residents' HF in LTC. ..
  32. doi request reprint Clinical, demographic and functional characteristics associated with pharmacotherapy for heart failure in older home care clients: a retrospective, population-level, cross-sectional study
    Andrea D Foebel
    Department of Health Studies Gerontology, University of Waterloo, Waterloo, Ontario, Canada
    Drugs Aging 28:561-73. 2011
    ..However, these first-line therapies are underused in older populations. This article describes the use and predictors of use of first-line HF therapies in a population-based cohort of older home care clients in Ontario, Canada...
  33. ncbi request reprint Metabolic profile and exercise capacity outcomes: their relationship to overweight and obesity in a Canadian cardiac rehabilitation setting
    Mamdouh M Shubair
    Department of Medicine, McMaster University, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada
    J Cardiopulm Rehabil 24:405-13. 2004
    ....
  34. ncbi request reprint Effects of exercise training in patients with heart failure: the Exercise Rehabilitation Trial (EXERT)
    Robert S McKelvie
    Division of Cardiology and Preventive Cardiology and Therapeutic Program, Hamilton Health Sciences Corporation, Hamilton, Ontario, Canada
    Am Heart J 144:23-30. 2002
    ..The purpose of this study was to examine the effects of exercise training on functional capacity in patients with heart failure...
  35. pmc Brachial Artery Endothelial Responses during Early Recovery from an Exercise Bout in Patients with Coronary Artery Disease
    Katharine D Currie
    Department of Kinesiology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1
    Biomed Res Int 2014:591918. 2014
    ..Furthermore, it highlights the necessity of both endothelial-dependent and endothelial-independent assessments when evaluating endothelial function changes with an intervention. ..
  36. doi request reprint Cardiovascular aging and exercise in healthy older adults
    George A Heckman
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin J Sport Med 18:479-85. 2008
    ....
  37. ncbi request reprint The impact of an outpatient heart failure clinic on hospital costs and admissions
    Susan J Gregoroff
    McMaster University, Hamilton Health Sciences General Site, Hamilton, Ontario, Canada
    Int J Health Care Qual Assur Inc Leadersh Health Serv 17:i-xi. 2004
    ....
  38. doi request reprint The Dutch Objective Burden Inventory: validity and reliability in a Canadian population of caregivers for people with heart failure
    Anthony Makdessi
    McMaster University, Hamilton, Ontario, Canada
    Eur J Cardiovasc Nurs 10:234-40. 2011
    ..Further testing is needed to determine floor and ceiling effects for DOBI items and responsiveness of this tool...
  39. ncbi request reprint Monitoring the response to pharmacologic therapy in patients with stable chronic heart failure: is BNP or NT-proBNP a useful assessment tool?
    Cynthia M Balion
    Hamilton Regional Laboratory Medicine Program, Hamilton, ON, Canada
    Clin Biochem 41:266-76. 2008
    ..We sought to determine whether B-type natriuretic peptide (BNP) or N-terminal proBNP (NT-proBNP) concentration changes occurred in parallel to changes in other measures of heart failure following treatment...
  40. ncbi request reprint Patient perception of the effect of treatment with candesartan in heart failure. Results of the candesartan in heart failure: assessment of reduction in mortality and morbidity (CHARM) programme
    Eileen O'Meara
    Department of Cardiology, Western Infirmary, Glasgow, Scotland G11 6NT, United Kingdom
    Eur J Heart Fail 7:650-6. 2005
    ..To evaluate the effect of the angiotensin receptor blocker candesartan on patients' perception of symptoms, using the McMaster Overall treatment evaluation (OTE), in a broad spectrum of patients with chronic heart failure (CHF)...
  41. ncbi request reprint Characterization of health-related quality of life in heart failure patients with preserved versus low ejection fraction in CHARM
    Eldrin F Lewis
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Eur J Heart Fail 9:83-91. 2007
    ..Limited comparative studies assessing the health-related quality of life (HRQL) in heart failure (HF) patients with preserved vs. low ejection fraction (LVEF) have been disparate...
  42. ncbi request reprint Diastolic dysfunction in heart failure with preserved systolic function: need for objective evidence:results from the CHARM Echocardiographic Substudy-CHARMES
    Hans Persson
    Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital Department of Cardiology, Stockholm, Sweden
    J Am Coll Cardiol 49:687-94. 2007
    ..We tested the hypothesis that diastolic dysfunction (DD) was an important predictor of cardiovascular (CV) death or heart failure (HF) hospitalization in a subset of patients (ejection fraction [EF] >40%) in the CHARM-Preserved study...
  43. ncbi request reprint Angiotensin receptor blockers in heart failure: meta-analysis of randomized controlled trials
    Philip Jong
    Heart and Stroke Richard Lewar Centre of Excellence, Division of Cardiology, University Health Network, University of Toronto, Toronto, Canada
    J Am Coll Cardiol 39:463-70. 2002
    ..We sought to determine the effect of angiotensin receptor blockers (ARBs) on mortality and hospitalization in patients with heart failure (HF)...
  44. ncbi request reprint Practical recommendations for the use of ACE inhibitors, beta-blockers, aldosterone antagonists and angiotensin receptor blockers in heart failure: putting guidelines into practice
    John McMurray
    Department of Cardiology, Western Infirmary, Glasgow, G12 8QQ, UK
    Eur J Heart Fail 7:710-21. 2005
    ..These practical recommendations are meant to serve as a supplement to, rather than replacement of, existing HF guidelines...
  45. ncbi request reprint Mortality and morbidity reduction with Candesartan in patients with chronic heart failure and left ventricular systolic dysfunction: results of the CHARM low-left ventricular ejection fraction trials
    James B Young
    Division of Medicine, The Cleveland Clinic Foundation and Kaufman Center for Heart Failure, 9500 Euclid Avenue T 13, Cleveland, OH 44195, USA
    Circulation 110:2618-26. 2004
    ..CHARM is a randomized, double-blind, placebo-controlled, multicenter, international trial program...
  46. pmc Reproducibility of peak oxygen uptake and other cardiopulmonary exercise testing parameters in patients with heart failure (from the Heart Failure and A Controlled Trial Investigating Outcomes of exercise traiNing)
    Daniel R Bensimhon
    LeBauer Cardiovascular Research Foundation, Greensboro, North Carolina, USA
    Am J Cardiol 102:712-7. 2008
    ..Therefore, in multicenter trials, there is no need to perform >1 baseline cardiopulmonary exercise test...
  47. pmc Canadian Cardiovascular Society Consensus Conference recommendations on heart failure update 2007: Prevention, management during intercurrent illness or acute decompensation, and use of biomarkers
    J Malcom O Arnold
    University of Western Ontario, London, Canada
    Can J Cardiol 23:21-45. 2007
    ....
  48. ncbi request reprint Association between psychotropic drug use and heart failure therapy in elderly long-term care residents
    George A Heckman
    J Am Geriatr Soc 54:1973-5. 2006
  49. ncbi request reprint Growth hormone therapy in heart failure: a novel therapy worthy of further consideration?
    Catherine Demers
    HHS General Division, Hamilton Ontario
    Expert Opin Investig Drugs 14:1009-18. 2005
    ..The randomised studies showing benefit consistently used growth hormone every other day. Further studies are needed to assess the potential role of this adjuvant therapy in patients with heart failure...
  50. pmc Canadian Cardiovascular Society consensus conference recommendations on heart failure 2006: diagnosis and management
    J Malcolm O Arnold
    University of Western Ontario, London, Canada
    Can J Cardiol 22:23-45. 2006
    ..The goal is to translate best evidence-based therapies into clinical practice with a measureable impact on the health of heart failure patients in Canada...