Isabella W Y Mak

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. doi request reprint Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone
    Isabella W Y Mak
    McMaster University, Hamilton, Ontario, Canada L8V 5C2
    Hum Pathol 41:1320-9. 2010
  2. doi request reprint Parathyroid hormone-related protein (PTHrP) modulates adhesion, migration and invasion in bone tumor cells
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    Bone 55:198-207. 2013
  3. pmc Investigation of FGFR2-IIIC signaling via FGF-2 ligand for advancing GCT stromal cell differentiation
    Shalini Singh
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 7:e46769. 2012
  4. ncbi request reprint Upregulation of MMP-13 via Runx2 in the stromal cell of Giant Cell Tumor of bone
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    Bone 45:377-86. 2009
  5. pmc Collagenase expression and activity in the stromal cells from giant cell tumour of bone
    Robert W Cowan
    Faculty of Health Sciences, McMaster University and the Juravinski Cancer Centre, Hamilton, Ontario, Canada
    Bone 44:865-71. 2009
  6. doi request reprint The role of TWIST as a regulator in giant cell tumor of bone
    Shalini Singh
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    J Cell Biochem 112:2287-95. 2011
  7. doi request reprint Transcriptomic and proteomic analyses in bone tumor cells: Deciphering parathyroid hormone-related protein regulation of the cell cycle and apoptosis
    Isabella W Y Mak
    Department of Oncology, McMaster University, Hamilton, Ontario, Canada
    J Bone Miner Res 27:1976-91. 2012
  8. pmc PTHrP induces autocrine/paracrine proliferation of bone tumor cells through inhibition of apoptosis
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 6:e19975. 2011
  9. doi request reprint ETV5 as a regulator of matrix metalloproteinase 2 in human chondrosarcoma
    Patricia F Power
    Department of Health Science Graduate Studies, McMaster University, Hamilton, Ontario, Canada
    J Orthop Res 31:493-501. 2013
  10. pmc AP-1 as a Regulator of MMP-13 in the Stromal Cell of Giant Cell Tumor of Bone
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, ON, Canada L8S 4L8
    Biochem Res Int 2011:164197. 2011

Collaborators

Detail Information

Publications10

  1. doi request reprint Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone
    Isabella W Y Mak
    McMaster University, Hamilton, Ontario, Canada L8V 5C2
    Hum Pathol 41:1320-9. 2010
    ..Future research will involve elucidation of the role of cell-cell/matrix communication pathways in bone resorption and tumorigenesis in GCT...
  2. doi request reprint Parathyroid hormone-related protein (PTHrP) modulates adhesion, migration and invasion in bone tumor cells
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    Bone 55:198-207. 2013
    ..Based on the data presented herein, we conclude that PTHrP excreted by GCT stromal cells increases bone tumor cell local invasiveness and migration...
  3. pmc Investigation of FGFR2-IIIC signaling via FGF-2 ligand for advancing GCT stromal cell differentiation
    Shalini Singh
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 7:e46769. 2012
    ..Our results indicate a significant role of FGFR-2 signaling in osteoblastic differentiation in GCT stromal cells...
  4. ncbi request reprint Upregulation of MMP-13 via Runx2 in the stromal cell of Giant Cell Tumor of bone
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    Bone 45:377-86. 2009
    ..Our study provides the first evidence that Runx2 may play a crucial role in cytokine-mediated MMP-13 expression in GCT stromal cells...
  5. pmc Collagenase expression and activity in the stromal cells from giant cell tumour of bone
    Robert W Cowan
    Faculty of Health Sciences, McMaster University and the Juravinski Cancer Centre, Hamilton, Ontario, Canada
    Bone 44:865-71. 2009
    ..The spindle-like stromal cells from GCT may therefore actively participate in the bone destruction that is characteristic of the tumour...
  6. doi request reprint The role of TWIST as a regulator in giant cell tumor of bone
    Shalini Singh
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    J Cell Biochem 112:2287-95. 2011
    ....
  7. doi request reprint Transcriptomic and proteomic analyses in bone tumor cells: Deciphering parathyroid hormone-related protein regulation of the cell cycle and apoptosis
    Isabella W Y Mak
    Department of Oncology, McMaster University, Hamilton, Ontario, Canada
    J Bone Miner Res 27:1976-91. 2012
    ....
  8. pmc PTHrP induces autocrine/paracrine proliferation of bone tumor cells through inhibition of apoptosis
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 6:e19975. 2011
    ..Thus PTHrP neutralizing immunotherapy is an intriguing potential therapeutic strategy for this tumor...
  9. doi request reprint ETV5 as a regulator of matrix metalloproteinase 2 in human chondrosarcoma
    Patricia F Power
    Department of Health Science Graduate Studies, McMaster University, Hamilton, Ontario, Canada
    J Orthop Res 31:493-501. 2013
    ..This data suggests that ETV5 has a significant role in regulating MMP2 expression and therefore matrix resorption in human chondrosarcoma, and thus may be a targetable upstream effector of the metastatic cascade in this cancer...
  10. pmc AP-1 as a Regulator of MMP-13 in the Stromal Cell of Giant Cell Tumor of Bone
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, ON, Canada L8S 4L8
    Biochem Res Int 2011:164197. 2011
    ..We conclude that there was no synergy found between RUNX2 and AP-1 in the regulation of the MMP13 expression and that these transcription factors may be independently regulated in these cells...