J B Mahony

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. pmc Incidence, clearance and predictors of human papillomavirus infection in women
    John W Sellors
    Health Services Delivery Research Unit, Father Sean O Sullivan Research Centre, St Joseph s Hospital and Department of Family Medicine, McMaster University, Hamilton, ON
    CMAJ 168:421-5. 2003
  2. pmc Structural characterization of a novel Chlamydia pneumoniae type III secretion-associated protein, Cpn0803
    Chris B Stone
    M G DeGroote Institute for Infectious Disease Research, Faculty of Health Sciences and the Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
    PLoS ONE 7:e30220. 2012
  3. pmc Chlamydia Pneumoniae CdsL Regulates CdsN ATPase Activity, and Disruption with a Peptide Mimetic Prevents Bacterial Invasion
    Chris B Stone
    Michael G DeGroote Institute for Infectious Disease Research, Faculty of Health Sciences, Department of Pathology and Molecular Medicine, McMaster University, Father Sean O Sullivan Research Centre, St Joseph s Healthcare Hamilton, ON, Canada
    Front Microbiol 2:21. 2011
  4. pmc Development of a sensitive loop-mediated isothermal amplification assay that provides specimen-to-result diagnosis of respiratory syncytial virus infection in 30 minutes
    James Mahony
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Clin Microbiol 51:2696-701. 2013
  5. doi request reprint Multiplex loop-mediated isothermal amplification (M-LAMP) assay for the detection of influenza A/H1, A/H3 and influenza B can provide a specimen-to-result diagnosis in 40 min with single genome copy sensitivity
    James Mahony
    Department of Pathology and Molecular Medicine, McMaster University, Canada Regional Virology and Chlamydiology Laboratory, St Joseph s Healthcare Hamilton, Hamilton, Ontario L8N 4A6, Canada
    J Clin Virol 58:127-31. 2013
  6. doi request reprint Molecular diagnosis of respiratory virus infections
    James B Mahony
    M G DeGroote Institute for Infectious Disease Research, St Joseph s Healthcare, Hamilton, Canada
    Crit Rev Clin Lab Sci 48:217-49. 2011
  7. pmc Prognosis of West Nile virus associated acute flaccid paralysis: a case series
    Jennie Johnstone
    Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada
    J Med Case Reports 5:395. 2011
  8. pmc Lack of association between vascular dementia and Chlamydia pneumoniae infection: a case-control study
    Soo Chan Carusone
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main St W, L8N 3Z5 Hamilton, Canada
    BMC Neurol 4:15. 2004
  9. pmc A novel inhibitor of Chlamydophila pneumoniae protein kinase D (PknD) inhibits phosphorylation of CdsD and suppresses bacterial replication
    Dustin L Johnson
    MG DeGroote Institute for Infectious Disease Research and the Department of Pathology and Molecular Medicine, McMaster University, Ontario, Canada
    BMC Microbiol 9:218. 2009
  10. pmc Interactions between flagellar and type III secretion proteins in Chlamydia pneumoniae
    Chris B Stone
    M, G, DeGroote Institute for Infectious Disease Research, Faculty of Health Sciences and the Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    BMC Microbiol 10:18. 2010

Collaborators

Detail Information

Publications59

  1. pmc Incidence, clearance and predictors of human papillomavirus infection in women
    John W Sellors
    Health Services Delivery Research Unit, Father Sean O Sullivan Research Centre, St Joseph s Hospital and Department of Family Medicine, McMaster University, Hamilton, ON
    CMAJ 168:421-5. 2003
    ..To better understand the natural history of HPV, we sought to determine the rates of incident and cleared carcinogenic HPV infection, by age, among women aged 15-49 years and to explore risk factors for incident infection...
  2. pmc Structural characterization of a novel Chlamydia pneumoniae type III secretion-associated protein, Cpn0803
    Chris B Stone
    M G DeGroote Institute for Infectious Disease Research, Faculty of Health Sciences and the Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
    PLoS ONE 7:e30220. 2012
    ..Also, the binding domains on Cpn0803 for CdsN, CdsQ, and CdsF were identified using Pepscan epitope mapping. Collectively, these data suggest that Cpn0803 plays a role in T3S...
  3. pmc Chlamydia Pneumoniae CdsL Regulates CdsN ATPase Activity, and Disruption with a Peptide Mimetic Prevents Bacterial Invasion
    Chris B Stone
    Michael G DeGroote Institute for Infectious Disease Research, Faculty of Health Sciences, Department of Pathology and Molecular Medicine, McMaster University, Father Sean O Sullivan Research Centre, St Joseph s Healthcare Hamilton, ON, Canada
    Front Microbiol 2:21. 2011
    ..CdsL on the ATPase, CdsN, and demonstrates that peptide mimetics can be used as anti-virulence factors to block bacterial invasion...
  4. pmc Development of a sensitive loop-mediated isothermal amplification assay that provides specimen-to-result diagnosis of respiratory syncytial virus infection in 30 minutes
    James Mahony
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Clin Microbiol 51:2696-701. 2013
    ..In summary, the M-LAMP assay had excellent sensitivity and specificity for detecting RSV A and B in NP specimens and, when coupled with a rapid specimen preparation method, could provide a specimen-to-result diagnosis time of 30 min. ..
  5. doi request reprint Multiplex loop-mediated isothermal amplification (M-LAMP) assay for the detection of influenza A/H1, A/H3 and influenza B can provide a specimen-to-result diagnosis in 40 min with single genome copy sensitivity
    James Mahony
    Department of Pathology and Molecular Medicine, McMaster University, Canada Regional Virology and Chlamydiology Laboratory, St Joseph s Healthcare Hamilton, Hamilton, Ontario L8N 4A6, Canada
    J Clin Virol 58:127-31. 2013
    ..Rapid isothermal amplification methods have recently been introduced and they offer significant advantages over PCR...
  6. doi request reprint Molecular diagnosis of respiratory virus infections
    James B Mahony
    M G DeGroote Institute for Infectious Disease Research, St Joseph s Healthcare, Hamilton, Canada
    Crit Rev Clin Lab Sci 48:217-49. 2011
    ..These resistance assays, together with viral load assays, will enable clinical laboratories to provide physicians with new and important information for optimal treatment of respiratory virus infections...
  7. pmc Prognosis of West Nile virus associated acute flaccid paralysis: a case series
    Jennie Johnstone
    Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada
    J Med Case Reports 5:395. 2011
    ..abstract:..
  8. pmc Lack of association between vascular dementia and Chlamydia pneumoniae infection: a case-control study
    Soo Chan Carusone
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main St W, L8N 3Z5 Hamilton, Canada
    BMC Neurol 4:15. 2004
    ..pneumoniae may play a role in vascular dementia. The objective of this study was to determine if there was an association between serological evidence of C. pneumoniae infection or inflammatory markers with vascular dementia...
  9. pmc A novel inhibitor of Chlamydophila pneumoniae protein kinase D (PknD) inhibits phosphorylation of CdsD and suppresses bacterial replication
    Dustin L Johnson
    MG DeGroote Institute for Infectious Disease Research and the Department of Pathology and Molecular Medicine, McMaster University, Ontario, Canada
    BMC Microbiol 9:218. 2009
    ..To further study the role of PknD in growth and development we sought to identify a PknD inhibitor to determine whether PknD activity is required for replication...
  10. pmc Interactions between flagellar and type III secretion proteins in Chlamydia pneumoniae
    Chris B Stone
    M, G, DeGroote Institute for Infectious Disease Research, Faculty of Health Sciences and the Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    BMC Microbiol 10:18. 2010
    ..Chlamydia pneumoniae is an obligate, intracellular pathogen whose genome contains at least three orthologs of flagellar proteins, namely FliI, FlhA and FliF, but the role of these proteins remains unknown...
  11. pmc Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic review
    Marek Smieja
    Dept of Pathology and Molecular Medicine, McMaster University, Hamilton ON, Canada
    BMC Infect Dis 2:21. 2002
    ..We performed a systematic review to determine whether the detection of C. pneumoniae DNA in peripheral blood mononuclear cells (PBMC) was associated with CV disease...
  12. pmc Smoking, season, and detection of Chlamydia pneumoniae DNA in clinically stable COPD patients
    Marek Smieja
    Department of Pathology and Molecular Medicine, St Joseph s Healthcare and McMaster University, Hamilton ON Canada
    BMC Infect Dis 2:12. 2002
    ..The prevalence and role of Chlamydia pneumoniae in chronic obstructive pulmonary disease (COPD) remain unclear, and molecular methods of detection may help clarify this relationship...
  13. pmc Cost analysis of multiplex PCR testing for diagnosing respiratory virus infections
    James B Mahony
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Clin Microbiol 47:2812-7. 2009
    ..We conclude that the use of the xTAG RVP test is the least costly strategy for the diagnosis of respiratory virus infections in children and would generate a significant savings for hospitals...
  14. pmc Detection of respiratory viruses by molecular methods
    James B Mahony
    Regional Virology Laboratory, St Joseph s Healthcare Hamilton, Hamilton, Ontario, Canada
    Clin Microbiol Rev 21:716-47. 2008
    ....
  15. pmc Development of a respiratory virus panel test for detection of twenty human respiratory viruses by use of multiplex PCR and a fluid microbead-based assay
    J Mahony
    Department of Pathology and Molecular Medicine, McMaster University, and St Joseph s Healthcare, Hamilton, Ontario, Canada
    J Clin Microbiol 45:2965-70. 2007
    ....
  16. pmc Molecular diagnosis of severe acute respiratory syndrome: the state of the art
    James B Mahony
    Regional Virology Laboratory, St Joseph s Hospital, 50 Charlton Ave East, Hamilton, ON L8N 4A6, Canada
    J Mol Diagn 7:551-9. 2005
    ..These and other issues related to diagnosis of SARS-CoV infection are discussed in this review...
  17. ncbi request reprint Development of a novel bead-based multiplex PCR assay for combined subtyping and oseltamivir resistance genotyping (H275Y) of seasonal and pandemic H1N1 influenza A viruses
    James B Mahony
    Regional Virology Laboratory, St Joseph s Healthcare, Hamilton, Ontario, Canada
    J Clin Virol 49:277-82. 2010
    ....
  18. pmc Performance and Cost evaluation of one commercial and six in-house conventional and real-time reverse transcription-pcr assays for detection of severe acute respiratory syndrome coronavirus
    James B Mahony
    McMaster University, Toronto, Ontario L8N 4A6, Canada
    J Clin Microbiol 42:1471-6. 2004
    ..The commercial assay cost was considerably higher at $40.37 per test. The results demonstrated good performance for all assays, providing laboratories that need to do SARS RNA testing with a choice of assay formats...
  19. ncbi request reprint Chlamydiae host cell interactions revealed using DNA microarrays
    James B Mahony
    Department of Pathology and Molecular Medicine, McMaster University, Regional Virology and Chlamydiology Laboratory, St Joseph s Healthcare, Hamilton, Ontario, Canada L8N 4A6
    Ann N Y Acad Sci 975:192-201. 2002
    ....
  20. ncbi request reprint Nucleic acid amplification-based diagnosis of respiratory virus infections
    James B Mahony
    Regional Virology Laboratory, St Joseph s Healthcare Hamilton, 50 Charlton Ave East, Hamilton, ON, L8N 4A6, Canada
    Expert Rev Anti Infect Ther 8:1273-92. 2010
    ..These resistance assays together with new viral load tests will enable clinical laboratories to provide physicians with important information for optimal treatment of patients...
  21. ncbi request reprint Multiplex PCR tests sentinel the appearance of pandemic influenza viruses including H1N1 swine influenza
    James B Mahony
    Department of Medicine, Pathology and Molecular Medicine, Institute for Infectious Diseases Research, McMaster University and the Father Sean O Sullivan Research Center, St Joseph s Healthcare, Hamilton, Canada
    J Clin Virol 45:200-2. 2009
    ..Diagnostic assays are required to detect novel influenza strains with pandemic potential...
  22. ncbi request reprint Chlamydia pneumoniae and atherosclerosis: does the evidence support a causal or contributory role?
    J B Mahony
    Department of Pathology and Molecular Medicine, McMaster University, and the Father Sean O Sullivan Research Center, St Joseph s Hospital, 50 Charlton Ave East, L8N 4A6, Hamilton, Ont, Canada
    FEMS Microbiol Lett 197:1-9. 2001
    ....
  23. pmc Evaluation of the NucliSens Basic Kit for detection of Chlamydia trachomatis and Neisseria gonorrhoeae in genital tract specimens using nucleic acid sequence-based amplification of 16S rRNA
    J B Mahony
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Clin Microbiol 39:1429-35. 2001
    ..gonorrhoeae and C. trachomatis, using a multiplex NASBA assay using primers for both bacteria. The NucliSens Basic Kit offers a versatile platform for the development of sensitive RNA detection assays for sexually transmitted diseases...
  24. pmc Circulating nucleic acids of Chlamydia pneumoniae and cytomegalovirus in patients undergoing coronary angiography
    M Smieja
    Hamilton Regional Laboratory Medicine Programme, McMaster University, Hamilton, Ontario, Canada
    J Clin Microbiol 39:596-600. 2001
    ..Neither C. pneumoniae nor CMV DNA detection increased after angioplasty, a procedure in which endothelium is disrupted. Larger prospective studies are needed to determine the prognostic significance of DNA detection...
  25. pmc Analytical sensitivity, reproducibility of results, and clinical performance of five PCR assays for detecting Chlamydia pneumoniae DNA in peripheral blood mononuclear cells
    J B Mahony
    Hamilton Regional Laboratory Medicine Program, St Joseph s Hospital, Hamilton, Ontario, Canada
    J Clin Microbiol 38:2622-7. 2000
    ..pneumoniae in clinical material...
  26. pmc Replicate PCR testing and probit analysis for detection and quantitation of Chlamydia pneumoniae in clinical specimens
    M Smieja
    Hamilton Regional Laboratory Medicine Programme, McMaster University, Hamilton, Ontario, Canada
    J Clin Microbiol 39:1796-801. 2001
    ..Due to sampling variability, PCR tests done without replication may miss a large proportion of positive specimens, particularly for specimens with small amounts of target C. pneumoniae DNA present...
  27. pmc Can an antibiotic (macrolide) prevent Chlamydia pneumoniae-induced atherosclerosis in a rabbit model?
    I W Fong
    Departments of Medicine, Laboratory Medicine and Pathology, St Michael s Hospital, University of Toronto, Toronto, Canada
    Clin Diagn Lab Immunol 6:891-4. 1999
    ..It is possible that longer or more aggressive antibiotic treatment may be needed to reverse preformed lesions or that antibiotics may not be of value once lesions have formed...
  28. pmc cDNA array analysis of altered gene expression in human endothelial cells in response to Chlamydia pneumoniae infection
    B K Coombes
    Department of Medical Sciences, McMaster University, and Father Sean O Sullivan Research Centre, St Joseph s Hospital, Hamilton, Ontario, Canada L8N
    Infect Immun 69:1420-7. 2001
    ..In addition, the use of cDNA microarrays may prove useful for the study of host cell responses to C. pneumoniae infection during latent and replicative stages of infection and related pathology...
  29. pmc Detection of chlamydial inclusions in cell culture or biopsy tissue by alkaline phosphatase-anti-alkaline phosphatase staining
    J B Mahony
    McMaster University Regional Virology Laboratory, Department of Biostatistics, Hamilton, Ontario, Canada
    J Clin Microbiol 25:1864-7. 1987
    ..This immunostain also allowed identification of chlamydial inclusions in endometrial biopsies from patients with tubal factor infertility or pelvic inflammatory disease...
  30. pmc De Novo induction of atherosclerosis by Chlamydia pneumoniae in a rabbit model
    I W Fong
    Departments of Medicine, St Michael s Hospital, University of Toronto, Toronto, Canada
    Infect Immun 67:6048-55. 1999
    ..pneumoniae. These data are compatible with de novo induction of atherogenesis by C. pneumoniae in rabbits and suggest that C. pneumoniae may be important in the pathogenesis of atherosclerosis in humans...
  31. pmc Comparison of self-collected vaginal, vulvar and urine samples with physician-collected cervical samples for human papillomavirus testing to detect high-grade squamous intraepithelial lesions
    J W Sellors
    Health Services Delivery Research Unit, Father Sean O Sullivan Research Centre, St Joseph s Hospital, Hamilton, Ont
    CMAJ 163:513-8. 2000
    ..We determined and compared the test characteristics of testing for HPV with samples obtained by patients and with samples obtained by their physicians...
  32. ncbi request reprint The role of cytology (Pap tests) and human papillomavirus testing in anal cancer screening
    Irving E Salit
    University Health Network, Toronto General Hospital, Ontario, Canada
    AIDS 24:1307-13. 2010
    ..To assess anal oncogenic human papillomavirus (HPV) and anal cytology as screening tests for detecting high-grade anal intraepithelial neoplasia (AIN 2+), as this is an immediate anal cancer precursor...
  33. pmc Development and evaluation of a flocked nasal midturbinate swab for self-collection in respiratory virus infection diagnostic testing
    Marek Smieja
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Clin Microbiol 48:3340-2. 2010
    ..Specific viruses were detected in swabs self-collected by 42/108 (38.9%) symptomatic volunteers by multiplex PCR...
  34. ncbi request reprint Adjunctive human papillomavirus testing in the 2-year follow-up of women with low-grade cervical cytologic abnormalities: a randomized trial and economic evaluation
    Alice Lytwyn
    Department of Pathology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ontario
    Arch Pathol Lab Med 127:1169-75. 2003
    ..Although human papillomavirus (HPV) testing may aid in managing low-grade abnormality on screening cervical cytology, patient compliance with repeat testing programs requires consideration...
  35. ncbi request reprint Combining human papillomavirus testing or cervicography with cytology to detect cervical neoplasia
    Michelle Howard
    Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada
    Arch Pathol Lab Med 128:1257-62. 2004
    ..Cervicography and oncogenic human papillomavirus (HPV) testing have been proposed for improving the accuracy of cervical cancer screening...
  36. ncbi request reprint Nucleic acid sequence based amplification (NASBA) of Chlamydia pneumoniae major outer membrane protein (ompA) mRNA with bioluminescent detection
    B K Coombes
    The Father Sean O Sullivan Research Center, St Joseph s Hospital, McMaster University, Hamilton, L8N 4A6, Canada
    Comb Chem High Throughput Screen 3:315-27. 2000
    ....
  37. ncbi request reprint Role of Ureaplasma urealyticum and other pathogens in the development of chronic lung disease of prematurity
    E E Wang
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Pediatr Infect Dis J 7:547-51. 1988
    ..The effect of interventions directed against U. urealyticum on the development of CLD deserves further study...
  38. ncbi request reprint Previous exposure to Chlamydia pneumoniae, Helicobacter pylori and other infections in Canadian patients with ischemic heart disease
    M Smieja
    St Joseph's Hospital, Hamilton, Canada
    Can J Cardiol 17:270-6. 2001
    ..A prospective validation of this association is needed...
  39. pmc Understanding and enhancing compliance with the second dose of hepatitis B vaccine: a cohort analysis and a randomized controlled trial
    J Sellors
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ont
    CMAJ 157:143-8. 1997
    ..To determine the predictors and extent of noncompliance with a second dose of hepatitis B vaccine and the effectiveness of a compliance enhancement strategy...
  40. pmc Randomised, blinded, placebo controlled trial of doxycycline for chronic seronegative arthritis
    M Smieja
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Ann Rheum Dis 60:1088-94. 2001
    ..To determine whether long term doxycycline improves symptoms in patients with chronic seronegative or reactive arthritis...
  41. pmc Chlamydia pneumoniae infection of human endothelial cells induces proliferation of smooth muscle cells via an endothelial cell-derived soluble factor(s)
    B K Coombes
    Regional Virology and Chlamydiology Laboratory, McMaster University, Hamilton, Ontario, Canada L8N 4A6
    Infect Immun 67:2909-15. 1999
    ..The ability of C. pneumoniae to elicit an endothelial cell-derived soluble factor(s) that stimulates SMC proliferation may be important in the pathogenesis of atherosclerosis...
  42. doi request reprint Risk factors and viruses associated with hospitalization due to lower respiratory tract infections in Canadian Inuit children : a case-control study
    Anna Banerji
    Department of Pediatrics and Dalla Lana School of Public Health, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Pediatr Infect Dis J 28:697-701. 2009
    ..To examine risk factors for lower respiratory tract infections (LRTI) hospital admission in the Canadian Arctic...
  43. ncbi request reprint Effect of routine use of a multiplex PCR for detection of vanA- and vanB- mediated enterococcal resistance on accuracy, costs and earlier reporting
    A Petrich
    Hamilton Regional Laboratory Medicine Program, McMaster University, Hamilton, ON, Canada
    Diagn Microbiol Infect Dis 41:215-20. 2001
    ..The sensitivity and specificity of MPCR were 98.4% and 96.1%. MPCR identifications of VRE were achieved approximately 48 h earlier than CBT and at 60% of the costs...
  44. ncbi request reprint Strategic targeting of essential host-pathogen interactions in chlamydial disease
    B K Coombes
    Department of Medical Sciences, McMaster University, Father Sean O Sullivan Research Centre, St Joseph s Healthcare, Hamilton, Ontario, Canada L8N 4A6
    Curr Drug Targets Infect Disord 2:201-16. 2002
    ..Using this knowledge, we discuss how strategically interfering with essential interactions between chlamydiae and the host cell could be exploited to develop an innovative, and potentially more relevant arsenal of therapeutic compounds...
  45. ncbi request reprint Asthma management by monitoring sputum neutrophil count
    Shelley Pallan
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, Hamilton, Ontario, Canada
    Chest 134:628-30. 2008
    ....
  46. doi request reprint The clinical need for the RVP test
    James B Mahony
    Department of Pathology and Molecular Medicine, McMaster University and St Joseph s Healthcare Hamilton, Hamilton, Canada
    J Clin Virol 40:S36-8. 2007
  47. doi request reprint Issues for reporting results
    Robert Lannigan
    London Health Science Centre and Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada
    J Clin Virol 40:S47-50. 2007
  48. ncbi request reprint Dendritic cell discoveries provide new insight into the cellular immunobiology of DNA vaccines
    B K Coombes
    Department of Medical Sciences, Father Sean O Sullivan Research Centre, St Joseph s Hospital, McMaster University, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
    Immunol Lett 78:103-11. 2001
    ....
  49. ncbi request reprint Chlamydia pneumoniae infection of endothelial cells induces transcriptional activation of platelet-derived growth factor-B: a potential link to intimal thickening in a rabbit model of atherosclerosis
    Brian K Coombes
    Department of Medical Sciences, Father Sean O Sullivan Research Centre, McMaster University, St Joseph s Hospital, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
    J Infect Dis 185:1621-30. 2002
    ..009). These results suggest that C. pneumoniae-induced SMC proliferation and intimal thickening may be mediated through PDGF-B and may be a molecular mechanism by which C. pneumoniae infection could contribute to atherogenesis...
  50. pmc Influence of clarithromycin on early atherosclerotic lesions after Chlamydia pneumoniae infection in a rabbit model
    Ignatius W Fong
    Department of Medicine, Division of Infectious Disease, St Michael s Hospital and University of Toronto, 30 Bond Street, Rm 4 179C, Toronto, M5B 1W8 Ontario, Canada
    Antimicrob Agents Chemother 46:2321-6. 2002
    ..Thus, clarithromycin administration modified C. pneumoniae-induced atherosclerotic lesions and reduced the ability to detect organism in tissue. Early treatment was more effective than delayed treatment...
  51. pmc Characterization of the putative type III secretion ATPase CdsN (Cpn0707) of Chlamydophila pneumoniae
    Chris B Stone
    M G DeGroote Institute for Infectious Disease Research, Faculty of Health Sciences and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Bacteriol 190:6580-8. 2008
    ..Interactions between CdsN, CdsD, and CopN represent novel interactions not previously reported for other bacterial T3S systems and may be important in the localization and/or function of the ATPase at the inner membrane of C. pneumoniae...
  52. pmc Interactions between CdsD, CdsQ, and CdsL, three putative Chlamydophila pneumoniae type III secretion proteins
    Dustin L Johnson
    M G DeGroote Institute for Infectious Disease Research, Faculty of Health Sciences and the Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Bacteriol 190:2972-80. 2008
    ..These novel protein interactions may play important roles in the assembly or function of the chlamydial T3S apparatus...
  53. ncbi request reprint Identification of MEK- and phosphoinositide 3-kinase-dependent signalling as essential events during Chlamydia pneumoniae invasion of HEp2 cells
    Brian K Coombes
    Father Sean O Sullivan Research Centre, St Joseph s Hospital, Hamilton, Ontario, Canada
    Cell Microbiol 4:447-60. 2002
    ..pneumoniae invasion. These results suggest that activation of specific cell signalling pathways is an essential strategy used by C. pneumoniae to invade epithelial cells...
  54. pmc Chlamydophila pneumoniae PknD exhibits dual amino acid specificity and phosphorylates Cpn0712, a putative type III secretion YscD homolog
    Dustin L Johnson
    Faculty of Health Sciences and Department of Pathology and Molecular Medicine, McMaster University, and Father Sean O Sullivan Research Centre, St Joseph s Hospital, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
    J Bacteriol 189:7549-55. 2007
    ....
  55. ncbi request reprint Interobserver agreement in the interpretation of anal intraepithelial neoplasia
    Alice Lytwyn
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Cancer 103:1447-56. 2005
    ..Screening for AIN using anal cytology was suggested. The authors evaluated agreement on cytologic and biopsy specimens from HIV-positive men undergoing anal carcinoma screening...
  56. pmc Prevalence of infection with carcinogenic human papillomavirus among older women
    John W Sellors
    CMAJ 167:871-3. 2002
  57. ncbi request reprint Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus
    Raymond H See
    University of British Columbia Centre for Disease Control, Vancouver, BC V5Z 4R4, Canada
    J Gen Virol 87:641-50. 2006
    ..Finally, the sera of vaccinated mice contained antibodies to S, further suggesting a role for this protein in conferring protective immunity against SARS-CoV infection...
  58. ncbi request reprint Severe acute respiratory syndrome coronavirus nucleocapsid protein expressed by an adenovirus vector is phosphorylated and immunogenic in mice
    Alexander N Zakhartchouk
    Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E3
    J Gen Virol 86:211-5. 2005
    ..Vaccination of C57BL/6 mice with Ad5-N-V generated potent SARS-CoV-specific humoral and T cell-mediated immune responses. These results show that Ad5-N-V may potentially be used as a SARS-CoV vaccine...
  59. doi request reprint The pathogens
    William F Carman
    West of Scotland Specialist Virology Centre, UK Clinical Virology Network, UK
    J Clin Virol 40:S5-S10. 2007