Research Topics
| J B MahonySummaryAffiliation: McMaster University Country: Canada Publications
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Detail Information
Publications
Incidence, clearance and predictors of human papillomavirus infection in womenJohn W Sellors
Health Services Delivery Research Unit, Father Sean O Sullivan Research Centre, St Joseph s Hospital and Department of Family Medicine, McMaster University, Hamilton, ON
CMAJ 168:421-5. 2003..To better understand the natural history of HPV, we sought to determine the rates of incident and cleared carcinogenic HPV infection, by age, among women aged 15-49 years and to explore risk factors for incident infection...
Molecular diagnosis of respiratory virus infectionsJames B Mahony
M G DeGroote Institute for Infectious Disease Research, St Joseph s Healthcare, Hamilton, Canada
Crit Rev Clin Lab Sci 48:217-49. 2011..These resistance assays, together with viral load assays, will enable clinical laboratories to provide physicians with new and important information for optimal treatment of respiratory virus infections...- Prognosis of West Nile virus associated acute flaccid paralysis: a case seriesJennie Johnstone
Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada
J Med Case Reports 5:395. 2011..abstract:.. - Lack of association between vascular dementia and Chlamydia pneumoniae infection: a case-control studySoo Chan Carusone
Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main St W, L8N 3Z5 Hamilton, Canada
BMC Neurol 4:15. 2004..pneumoniae may play a role in vascular dementia. The objective of this study was to determine if there was an association between serological evidence of C. pneumoniae infection or inflammatory markers with vascular dementia... - A novel inhibitor of Chlamydophila pneumoniae protein kinase D (PknD) inhibits phosphorylation of CdsD and suppresses bacterial replicationDustin L Johnson
MG DeGroote Institute for Infectious Disease Research and the Department of Pathology and Molecular Medicine, McMaster University, Ontario, Canada
BMC Microbiol 9:218. 2009..To further study the role of PknD in growth and development we sought to identify a PknD inhibitor to determine whether PknD activity is required for replication... - Interactions between flagellar and type III secretion proteins in Chlamydia pneumoniaeChris B Stone
M, G, DeGroote Institute for Infectious Disease Research, Faculty of Health Sciences and the Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
BMC Microbiol 10:18. 2010..Chlamydia pneumoniae is an obligate, intracellular pathogen whose genome contains at least three orthologs of flagellar proteins, namely FliI, FlhA and FliF, but the role of these proteins remains unknown... - Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic reviewMarek Smieja
Dept of Pathology and Molecular Medicine, McMaster University, Hamilton ON, Canada
BMC Infect Dis 2:21. 2002..We performed a systematic review to determine whether the detection of C. pneumoniae DNA in peripheral blood mononuclear cells (PBMC) was associated with CV disease... - Smoking, season, and detection of Chlamydia pneumoniae DNA in clinically stable COPD patientsMarek Smieja
Department of Pathology and Molecular Medicine, St Joseph s Healthcare and McMaster University, Hamilton ON Canada
BMC Infect Dis 2:12. 2002..The prevalence and role of Chlamydia pneumoniae in chronic obstructive pulmonary disease (COPD) remain unclear, and molecular methods of detection may help clarify this relationship... - Multiplex PCR tests sentinel the appearance of pandemic influenza viruses including H1N1 swine influenzaJames B Mahony
Department of Medicine, Pathology and Molecular Medicine, Institute for Infectious Diseases Research, McMaster University and the Father Sean O Sullivan Research Center, St Joseph s Healthcare, Hamilton, Canada
J Clin Virol 45:200-2. 2009..Diagnostic assays are required to detect novel influenza strains with pandemic potential... - Molecular diagnosis of severe acute respiratory syndrome: the state of the artJames B Mahony
Regional Virology Laboratory, St Joseph s Hospital, 50 Charlton Ave East, Hamilton, ON L8N 4A6, Canada
J Mol Diagn 7:551-9. 2005..These and other issues related to diagnosis of SARS-CoV infection are discussed in this review... - Nucleic acid amplification-based diagnosis of respiratory virus infectionsJames B Mahony
Regional Virology Laboratory, St Joseph s Healthcare Hamilton, 50 Charlton Ave East, Hamilton, ON, L8N 4A6, Canada
Expert Rev Anti Infect Ther 8:1273-92. 2010..These resistance assays together with new viral load tests will enable clinical laboratories to provide physicians with important information for optimal treatment of patients... 
Chlamydiae host cell interactions revealed using DNA microarraysJames B Mahony
Department of Pathology and Molecular Medicine, McMaster University, Regional Virology and Chlamydiology Laboratory, St Joseph s Healthcare, Hamilton, Ontario, Canada L8N 4A6
Ann N Y Acad Sci 975:192-201. 2002....- Performance and Cost evaluation of one commercial and six in-house conventional and real-time reverse transcription-pcr assays for detection of severe acute respiratory syndrome coronavirusJames B Mahony
McMaster University, Toronto, Ontario L8N 4A6, Canada
J Clin Microbiol 42:1471-6. 2004..The commercial assay cost was considerably higher at $40.37 per test. The results demonstrated good performance for all assays, providing laboratories that need to do SARS RNA testing with a choice of assay formats... - Chlamydia pneumoniae and atherosclerosis: does the evidence support a causal or contributory role?J B Mahony
Department of Pathology and Molecular Medicine, McMaster University, and the Father Sean O Sullivan Research Center, St Joseph s Hospital, 50 Charlton Ave East, L8N 4A6, Hamilton, Ont, Canada
FEMS Microbiol Lett 197:1-9. 2001.... - Development of a novel bead-based multiplex PCR assay for combined subtyping and oseltamivir resistance genotyping (H275Y) of seasonal and pandemic H1N1 influenza A virusesJames B Mahony
Regional Virology Laboratory, St Joseph s Healthcare, Hamilton, Ontario, Canada
J Clin Virol 49:277-82. 2010.... - Development of a respiratory virus panel test for detection of twenty human respiratory viruses by use of multiplex PCR and a fluid microbead-based assayJ Mahony
Department of Pathology and Molecular Medicine, McMaster University, and St Joseph s Healthcare, Hamilton, Ontario, Canada
J Clin Microbiol 45:2965-70. 2007.... - Cost analysis of multiplex PCR testing for diagnosing respiratory virus infectionsJames B Mahony
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
J Clin Microbiol 47:2812-7. 2009..We conclude that the use of the xTAG RVP test is the least costly strategy for the diagnosis of respiratory virus infections in children and would generate a significant savings for hospitals... - Detection of respiratory viruses by molecular methodsJames B Mahony
Regional Virology Laboratory, St Joseph s Healthcare Hamilton, Hamilton, Ontario, Canada
Clin Microbiol Rev 21:716-47. 2008.... - Evaluation of the NucliSens Basic Kit for detection of Chlamydia trachomatis and Neisseria gonorrhoeae in genital tract specimens using nucleic acid sequence-based amplification of 16S rRNAJ B Mahony
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
J Clin Microbiol 39:1429-35. 2001..gonorrhoeae and C. trachomatis, using a multiplex NASBA assay using primers for both bacteria. The NucliSens Basic Kit offers a versatile platform for the development of sensitive RNA detection assays for sexually transmitted diseases... - Circulating nucleic acids of Chlamydia pneumoniae and cytomegalovirus in patients undergoing coronary angiographyM Smieja
Hamilton Regional Laboratory Medicine Programme, McMaster University, Hamilton, Ontario, Canada
J Clin Microbiol 39:596-600. 2001..Neither C. pneumoniae nor CMV DNA detection increased after angioplasty, a procedure in which endothelium is disrupted. Larger prospective studies are needed to determine the prognostic significance of DNA detection... - Analytical sensitivity, reproducibility of results, and clinical performance of five PCR assays for detecting Chlamydia pneumoniae DNA in peripheral blood mononuclear cellsJ B Mahony
Hamilton Regional Laboratory Medicine Program, St Joseph s Hospital, Hamilton, Ontario, Canada
J Clin Microbiol 38:2622-7. 2000..pneumoniae in clinical material... - Can an antibiotic (macrolide) prevent Chlamydia pneumoniae-induced atherosclerosis in a rabbit model?I W Fong
Departments of Medicine, Laboratory Medicine and Pathology, St Michael s Hospital, University of Toronto, Toronto, Canada
Clin Diagn Lab Immunol 6:891-4. 1999..It is possible that longer or more aggressive antibiotic treatment may be needed to reverse preformed lesions or that antibiotics may not be of value once lesions have formed... - Replicate PCR testing and probit analysis for detection and quantitation of Chlamydia pneumoniae in clinical specimensM Smieja
Hamilton Regional Laboratory Medicine Programme, McMaster University, Hamilton, Ontario, Canada
J Clin Microbiol 39:1796-801. 2001..Due to sampling variability, PCR tests done without replication may miss a large proportion of positive specimens, particularly for specimens with small amounts of target C. pneumoniae DNA present... - cDNA array analysis of altered gene expression in human endothelial cells in response to Chlamydia pneumoniae infectionB K Coombes
Department of Medical Sciences, McMaster University, and Father Sean O Sullivan Research Centre, St Joseph s Hospital, Hamilton, Ontario, Canada L8N
Infect Immun 69:1420-7. 2001..In addition, the use of cDNA microarrays may prove useful for the study of host cell responses to C. pneumoniae infection during latent and replicative stages of infection and related pathology... - Detection of chlamydial inclusions in cell culture or biopsy tissue by alkaline phosphatase-anti-alkaline phosphatase stainingJ B Mahony
McMaster University Regional Virology Laboratory, Department of Biostatistics, Hamilton, Ontario, Canada
J Clin Microbiol 25:1864-7. 1987..This immunostain also allowed identification of chlamydial inclusions in endometrial biopsies from patients with tubal factor infertility or pelvic inflammatory disease... - De Novo induction of atherosclerosis by Chlamydia pneumoniae in a rabbit modelI W Fong
Departments of Medicine, St Michael s Hospital, University of Toronto, Toronto, Canada
Infect Immun 67:6048-55. 1999..pneumoniae. These data are compatible with de novo induction of atherogenesis by C. pneumoniae in rabbits and suggest that C. pneumoniae may be important in the pathogenesis of atherosclerosis in humans... - Comparison of self-collected vaginal, vulvar and urine samples with physician-collected cervical samples for human papillomavirus testing to detect high-grade squamous intraepithelial lesionsJ W Sellors
Health Services Delivery Research Unit, Father Sean O Sullivan Research Centre, St Joseph s Hospital, Hamilton, Ont
CMAJ 163:513-8. 2000..We determined and compared the test characteristics of testing for HPV with samples obtained by patients and with samples obtained by their physicians... - Development and evaluation of a flocked nasal midturbinate swab for self-collection in respiratory virus infection diagnostic testingMarek Smieja
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
J Clin Microbiol 48:3340-2. 2010..Specific viruses were detected in swabs self-collected by 42/108 (38.9%) symptomatic volunteers by multiplex PCR... - The role of cytology (Pap tests) and human papillomavirus testing in anal cancer screeningIrving E Salit
University Health Network, Toronto General Hospital, Ontario, Canada
AIDS 24:1307-13. 2010..To assess anal oncogenic human papillomavirus (HPV) and anal cytology as screening tests for detecting high-grade anal intraepithelial neoplasia (AIN 2+), as this is an immediate anal cancer precursor... - Adjunctive human papillomavirus testing in the 2-year follow-up of women with low-grade cervical cytologic abnormalities: a randomized trial and economic evaluationAlice Lytwyn
Department of Pathology, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario
Arch Pathol Lab Med 127:1169-75. 2003..CONCLUSIONS: Combined testing was more costly but may detect more cases of cervical intraepithelial neoplasia 2/3 than Pap test alone. However, poor adherence limits usefulness of a management strategy that requires repeated follow-up... - Combining human papillomavirus testing or cervicography with cytology to detect cervical neoplasiaMichelle Howard
Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada
Arch Pathol Lab Med 128:1257-62. 2004..Cervicography and oncogenic human papillomavirus (HPV) testing have been proposed for improving the accuracy of cervical cancer screening... - Previous exposure to Chlamydia pneumoniae, Helicobacter pylori and other infections in Canadian patients with ischemic heart diseaseM Smieja
St Joseph's Hospital, Hamilton, Canada
Can J Cardiol 17:270-6. 2001..A prospective validation of this association is needed... - Chlamydia pneumoniae infection of human endothelial cells induces proliferation of smooth muscle cells via an endothelial cell-derived soluble factor(s)B K Coombes
Regional Virology and Chlamydiology Laboratory, McMaster University, Hamilton, Ontario, Canada L8N 4A6
Infect Immun 67:2909-15. 1999..The ability of C. pneumoniae to elicit an endothelial cell-derived soluble factor(s) that stimulates SMC proliferation may be important in the pathogenesis of atherosclerosis... - Randomised, blinded, placebo controlled trial of doxycycline for chronic seronegative arthritisM Smieja
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
Ann Rheum Dis 60:1088-94. 2001..To determine whether long term doxycycline improves symptoms in patients with chronic seronegative or reactive arthritis... - Understanding and enhancing compliance with the second dose of hepatitis B vaccine: a cohort analysis and a randomized controlled trialJ Sellors
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ont
CMAJ 157:143-8. 1997..To determine the predictors and extent of noncompliance with a second dose of hepatitis B vaccine and the effectiveness of a compliance enhancement strategy... - Nucleic acid sequence based amplification (NASBA) of Chlamydia pneumoniae major outer membrane protein (ompA) mRNA with bioluminescent detectionB K Coombes
The Father Sean O Sullivan Research Center, St Joseph s Hospital, McMaster University, Hamilton, L8N 4A6, Canada
Comb Chem High Throughput Screen 3:315-27. 2000.... - Risk factors and viruses associated with hospitalization due to lower respiratory tract infections in Canadian Inuit children : a case-control studyAnna Banerji
Department of Pediatrics and Dalla Lana School of Public Health, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
Pediatr Infect Dis J 28:697-701. 2009..To examine risk factors for lower respiratory tract infections (LRTI) hospital admission in the Canadian Arctic... - Effect of routine use of a multiplex PCR for detection of vanA- and vanB- mediated enterococcal resistance on accuracy, costs and earlier reportingA Petrich
Hamilton Regional Laboratory Medicine Program, McMaster University, Hamilton, ON, Canada
Diagn Microbiol Infect Dis 41:215-20. 2001..The sensitivity and specificity of MPCR were 98.4% and 96.1%. MPCR identifications of VRE were achieved approximately 48 h earlier than CBT and at 60% of the costs... - Role of Ureaplasma urealyticum and other pathogens in the development of chronic lung disease of prematurityE E Wang
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
Pediatr Infect Dis J 7:547-51. 1988..The effect of interventions directed against U. urealyticum on the development of CLD deserves further study... - Strategic targeting of essential host-pathogen interactions in chlamydial diseaseB K Coombes
Department of Medical Sciences, McMaster University, Father Sean O'Sullivan Research Centre, St. Joseph's Healthcare, Hamilton, Ontario, Canada L8N 4A6
Curr Drug Targets Infect Disord 2:201-16. 2002..Using this knowledge, we discuss how strategically interfering with essential interactions between chlamydiae and the host cell could be exploited to develop an innovative, and potentially more relevant arsenal of therapeutic compounds... - Asthma management by monitoring sputum neutrophil countShelley Pallan
Firestone Institute for Respiratory Health, St Joseph s Healthcare, Hamilton, Ontario, Canada
Chest 134:628-30. 2008.... - Issues for reporting resultsRobert Lannigan
London Health Science Centre and Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada
J Clin Virol 40:S47-50. 2007 - The clinical need for the RVP testJames B Mahony
Department of Pathology and Molecular Medicine, McMaster University and St. Joseph's Healthcare Hamilton, Hamilton, Canada
J Clin Virol 40:S36-8. 2007 - Dendritic cell discoveries provide new insight into the cellular immunobiology of DNA vaccinesB K Coombes
Department of Medical Sciences, Father Sean O Sullivan Research Centre, St Joseph s Hospital, McMaster University, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
Immunol Lett 78:103-11. 2001.... - Influence of clarithromycin on early atherosclerotic lesions after Chlamydia pneumoniae infection in a rabbit modelIgnatius W Fong
Department of Medicine, Division of Infectious Disease, St Michael s Hospital and University of Toronto, 30 Bond Street, Rm 4 179C, Toronto, M5B 1W8 Ontario, Canada
Antimicrob Agents Chemother 46:2321-6. 2002..Thus, clarithromycin administration modified C. pneumoniae-induced atherosclerotic lesions and reduced the ability to detect organism in tissue. Early treatment was more effective than delayed treatment... - Chlamydia pneumoniae infection of endothelial cells induces transcriptional activation of platelet-derived growth factor-B: a potential link to intimal thickening in a rabbit model of atherosclerosisBrian K Coombes
Department of Medical Sciences, Father Sean O Sullivan Research Centre, McMaster University, St Joseph s Hospital, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
J Infect Dis 185:1621-30. 2002..009). These results suggest that C. pneumoniae-induced SMC proliferation and intimal thickening may be mediated through PDGF-B and may be a molecular mechanism by which C. pneumoniae infection could contribute to atherogenesis... - Interobserver agreement in the interpretation of anal intraepithelial neoplasiaAlice Lytwyn
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
Cancer 103:1447-56. 2005..76 to 0.94 for biopsy specimens. CONCLUSIONS: Agreement for cytologic and biopsy interpretations was generally at least moderate. Nevertheless, these results supported the need for disease indicators with greater reliability... - Characterization of the putative type III secretion ATPase CdsN (Cpn0707) of Chlamydophila pneumoniaeChris B Stone
M G DeGroote Institute for Infectious Disease Research, Faculty of Health Sciences and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
J Bacteriol 190:6580-8. 2008..Interactions between CdsN, CdsD, and CopN represent novel interactions not previously reported for other bacterial T3S systems and may be important in the localization and/or function of the ATPase at the inner membrane of C. pneumoniae... - Chlamydophila pneumoniae PknD exhibits dual amino acid specificity and phosphorylates Cpn0712, a putative type III secretion YscD homologDustin L Johnson
Faculty of Health Sciences and Department of Pathology and Molecular Medicine, McMaster University, and Father Sean O Sullivan Research Centre, St Joseph s Hospital, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
J Bacteriol 189:7549-55. 2007.... - Interactions between CdsD, CdsQ, and CdsL, three putative Chlamydophila pneumoniae type III secretion proteinsDustin L Johnson
M G DeGroote Institute for Infectious Disease Research, Faculty of Health Sciences and the Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
J Bacteriol 190:2972-80. 2008..These novel protein interactions may play important roles in the assembly or function of the chlamydial T3S apparatus... - Identification of MEK- and phosphoinositide 3-kinase-dependent signalling as essential events during Chlamydia pneumoniae invasion of HEp2 cellsBrian K Coombes
Father Sean O'Sullivan Research Centre, St. Joseph's Hospital, Hamilton, Ontario, Canada
Cell Microbiol 4:447-60. 2002..pneumoniae invasion. These results suggest that activation of specific cell signalling pathways is an essential strategy used by C. pneumoniae to invade epithelial cells... - Prevalence of infection with carcinogenic human papillomavirus among older womenJohn W Sellors
CMAJ 167:871-3. 2002 - Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirusRaymond H See
University of British Columbia Centre for Disease Control, Vancouver, BC V5Z 4R4, Canada
J Gen Virol 87:641-50. 2006..Finally, the sera of vaccinated mice contained antibodies to S, further suggesting a role for this protein in conferring protective immunity against SARS-CoV infection... - Severe acute respiratory syndrome coronavirus nucleocapsid protein expressed by an adenovirus vector is phosphorylated and immunogenic in miceAlexander N Zakhartchouk
Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E3
J Gen Virol 86:211-5. 2005..Vaccination of C57BL/6 mice with Ad5-N-V generated potent SARS-CoV-specific humoral and T cell-mediated immune responses. These results show that Ad5-N-V may potentially be used as a SARS-CoV vaccine... - The pathogensWilliam F Carman
West of Scotland Specialist Virology Centre, UK Clinical Virology Network, UK
J Clin Virol 40:S5-S10. 2007