Glenda Macqueen

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. pmc A postmenopausal woman presenting with Ekbom syndrome associated with recurrent depressive disorder: a case report
    Courtney Mahler
    McMaster University, 1280 Main St, West, Hamilton, Ontario, L8S 4L8, Canada
    Cases J 1:54. 2008
  2. pmc Psychological factors in asthma
    Ryan J Van Lieshout
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON
    Allergy Asthma Clin Immunol 4:12-28. 2008
  3. ncbi request reprint Bipolar II disorder: symptoms, course, and response to treatment
    G M MacQueen
    McMaster University, McMaster University Medical Center, Hamilton, Ontario, Canada
    Psychiatr Serv 52:358-61. 2001
  4. ncbi request reprint Cognitive effects of atypical antipsychotics: focus on bipolar spectrum disorders
    Glenda Macqueen
    St Joseph s Center for Mental Health Services, D1, Mood Disorders Program, 100 West 5th St, Hamilton, ON, L9C 2E4, Canada
    Bipolar Disord 5:53-61. 2003
  5. ncbi request reprint Desipramine treatment reduces the long-term behavioural and neurochemical sequelae of early-life maternal separation
    Glenda M MacQueen
    Mood Disorders Program, McMaster University, Hamilton, Ontario, Canada
    Int J Neuropsychopharmacol 6:391-6. 2003
  6. ncbi request reprint Subsyndromal symptoms assessed in longitudinal, prospective follow-up of a cohort of patients with bipolar disorder
    Glenda M MacQueen
    Mood Disorders Program, McMaster University, Hamilton, ON, Canada
    Bipolar Disord 5:349-55. 2003
  7. pmc The long-term impact of treatment with electroconvulsive therapy on discrete memory systems in patients with bipolar disorder
    Glenda Macqueen
    Mood Disorder Program, St Joseph s Healthcare, McMaster University, Hamilton, Ont
    J Psychiatry Neurosci 32:241-9. 2007
  8. ncbi request reprint Bilateral hippocampal volume increases after long-term lithium treatment in patients with bipolar disorder: a longitudinal MRI study
    Kaan Yucel
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, 100 West 5th Street, Hamilton, ON, L8N 3K7, Canada
    Psychopharmacology (Berl) 195:357-67. 2007
  9. pmc Course of illness, hippocampal function, and hippocampal volume in major depression
    Glenda M MacQueen
    Mood Disorders Program, Department of Radiology, McMaster University, Hamilton, ON, Canada L8N 3Z5
    Proc Natl Acad Sci U S A 100:1387-92. 2003
  10. doi request reprint Posterior hippocampal volumes are associated with remission rates in patients with major depressive disorder
    Glenda M MacQueen
    Mood Disorders Program, St Joseph s Healthcare Hamilton, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Biol Psychiatry 64:880-3. 2008

Collaborators

Detail Information

Publications52

  1. pmc A postmenopausal woman presenting with Ekbom syndrome associated with recurrent depressive disorder: a case report
    Courtney Mahler
    McMaster University, 1280 Main St, West, Hamilton, Ontario, L8S 4L8, Canada
    Cases J 1:54. 2008
    ..abstract:..
  2. pmc Psychological factors in asthma
    Ryan J Van Lieshout
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON
    Allergy Asthma Clin Immunol 4:12-28. 2008
    ....
  3. ncbi request reprint Bipolar II disorder: symptoms, course, and response to treatment
    G M MacQueen
    McMaster University, McMaster University Medical Center, Hamilton, Ontario, Canada
    Psychiatr Serv 52:358-61. 2001
    ..Preliminary studies suggest that the newer anticonvulsants may be of benefit for patients with bipolar II disorder, while other data suggest that there may be a greater role for antidepressant medications...
  4. ncbi request reprint Cognitive effects of atypical antipsychotics: focus on bipolar spectrum disorders
    Glenda Macqueen
    St Joseph s Center for Mental Health Services, D1, Mood Disorders Program, 100 West 5th St, Hamilton, ON, L9C 2E4, Canada
    Bipolar Disord 5:53-61. 2003
    ..Studies to determine if current treatments for bipolar disorder can prevent, delay, or even improve cognitive dysfunction are needed...
  5. ncbi request reprint Desipramine treatment reduces the long-term behavioural and neurochemical sequelae of early-life maternal separation
    Glenda M MacQueen
    Mood Disorders Program, McMaster University, Hamilton, Ontario, Canada
    Int J Neuropsychopharmacol 6:391-6. 2003
    ..These results suggest that intervention following early stress may eliminate the long-term vulnerability to behavioural and biochemical dysfunction that occurs following this early chronic stress...
  6. ncbi request reprint Subsyndromal symptoms assessed in longitudinal, prospective follow-up of a cohort of patients with bipolar disorder
    Glenda M MacQueen
    Mood Disorders Program, McMaster University, Hamilton, ON, Canada
    Bipolar Disord 5:349-55. 2003
    ..This study examined factors associated with persistent subsyndromal symptoms in a well characterized group of BD patients who were prospectively followed for an average of 3 years...
  7. pmc The long-term impact of treatment with electroconvulsive therapy on discrete memory systems in patients with bipolar disorder
    Glenda Macqueen
    Mood Disorder Program, St Joseph s Healthcare, McMaster University, Hamilton, Ont
    J Psychiatry Neurosci 32:241-9. 2007
    ..We aimed to examine whether long-term effects of ECT on discrete memory systems could be detected in patients with BD...
  8. ncbi request reprint Bilateral hippocampal volume increases after long-term lithium treatment in patients with bipolar disorder: a longitudinal MRI study
    Kaan Yucel
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, 100 West 5th Street, Hamilton, ON, L8N 3K7, Canada
    Psychopharmacology (Berl) 195:357-67. 2007
    ..In particular, treatment with lithium may exert long-term effects on hippocampal volume, influencing cognitive outcomes in BD patients...
  9. pmc Course of illness, hippocampal function, and hippocampal volume in major depression
    Glenda M MacQueen
    Mood Disorders Program, Department of Radiology, McMaster University, Hamilton, ON, Canada L8N 3Z5
    Proc Natl Acad Sci U S A 100:1387-92. 2003
    ..Reductions in hippocampal volume may not antedate illness onset, but volume may decrease at the greatest rate in the early years after illness onset...
  10. doi request reprint Posterior hippocampal volumes are associated with remission rates in patients with major depressive disorder
    Glenda M MacQueen
    Mood Disorders Program, St Joseph s Healthcare Hamilton, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Biol Psychiatry 64:880-3. 2008
    ..The hippocampus (HC) is smaller in patients with recurrent major depressive disorder (MDD), but few longitudinal studies have examined whether volume is associated with clinically meaningful outcomes such as response to treatment...
  11. ncbi request reprint Performance of heterozygous brain-derived neurotrophic factor knockout mice on behavioral analogues of anxiety, nociception, and depression
    G M MacQueen
    Department of Psychiatry and Behavioral Neurosciences, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Behav Neurosci 115:1145-53. 2001
    ..Overall, heterozygous mice were not more likely to display anxious or depressive-like behaviors and, consequently, may not constitute a murine model of genetic vulnerability to mood and anxiety disorders...
  12. ncbi request reprint Special issues in the management of depression in women
    Glenda Macqueen
    McMaster University, Hamilton, Ontario
    Can J Psychiatry 49:27S-40S. 2004
    ..The management of women with depression can be done safely and effectively using antidepressants and alternative interventions throughout the life cycle...
  13. ncbi request reprint Neonatal maternal separation causes colonic dysfunction in rat pups including impaired host resistance
    Mélanie G Gareau
    Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Pediatr Res 59:83-8. 2006
    ..Our studies indicate that early psychological trauma predisposes neonatal rats to develop persistent mucosal barrier dysfunction, including impaired host defense to luminal bacteria, by a mechanism involving peripheral CRH receptors...
  14. doi request reprint Bacterial infection causes stress-induced memory dysfunction in mice
    Mélanie G Gareau
    Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada
    Gut 60:307-17. 2011
    ..Whether intestinal events, such as enteric bacterial infections and bacterial colonisation, exert a reciprocal effect on stress-associated behaviour is not well established...
  15. pmc Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation
    Mélanie G Gareau
    Intestinal Disease Research Program, Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Gut 56:1522-8. 2007
    ..We previously showed that neonatal maternal separation (MS) of rat pups causes immediate and long-term changes in intestinal physiology...
  16. doi request reprint Increased subgenual prefrontal cortex size in remitted patients with major depressive disorder
    Kaan Yucel
    Mood Disorders Program, St Joseph s Healthcare Hamilton, McMaster University, Hamilton, Ontario, Canada
    Psychiatry Res 173:71-6. 2009
    ..Our findings demonstrate SGPFC volume increases in association with long-term antidepressant therapy and suggest that this result may be linked to positive clinical response...
  17. ncbi request reprint Impact of comorbid anxiety disorders on outcome in a cohort of patients with bipolar disorder
    Khrista R Boylan
    Mood Disorders Program, Center for Mountain Health Services, St Joseph s Hospital, Hamilton, Ontario, Canada
    J Clin Psychiatry 65:1106-13. 2004
    ..Although it is well recognized that anxiety disorders often co-occur with bipolar disorder, few studies have examined the impact of more than 1 anxiety disorder on long-term outcome in patients with bipolar disorder...
  18. doi request reprint Computational modeling and empirical studies of hippocampal neurogenesis-dependent memory: Effects of interference, stress and depression
    Suzanna Becker
    Department of Psychology Neuroscience and Behaviour, McMaster University, Building 34, Room 312 1280 Main St West Hamilton, ON L8S4K1, Canada
    Brain Res 1299:45-54. 2009
    ..The potential to detect very early signs of major depression using simple neurogenesis-dependent cognitive tests could have important implications for the diagnosis and treatment of this debilitating and highly prevalent disorder...
  19. ncbi request reprint Successful computer-assisted cognitive remediation therapy in patients with unipolar depression: a proof of principle study
    Safa Elgamal
    McMaster University, Hamilton, Ontario, Canada
    Psychol Med 37:1229-38. 2007
    ....
  20. pmc Antidepressant monotherapy vs sequential pharmacotherapy and mindfulness-based cognitive therapy, or placebo, for relapse prophylaxis in recurrent depression
    Zindel V Segal
    Centre for Addiction and Mental Health, Toronto, ON, Canada
    Arch Gen Psychiatry 67:1256-64. 2010
    ..Mindfulness-based cognitive therapy (MBCT) is a group-based psychosocial intervention designed to enhance self-management of prodromal symptoms associated with depressive relapse...
  21. doi request reprint A randomized, double-blind, controlled trial evaluating the effect of intranasal insulin on neurocognitive function in euthymic patients with bipolar disorder
    Roger S McIntyre
    Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Bipolar Disord 14:697-706. 2012
    ..In keeping with this view, we tested the hypothesis that intranasal insulin administration would improve measures of neurocognitive performance in euthymic adults with bipolar disorder...
  22. ncbi request reprint The Canadian Network for Mood and Anxiety Treatments (CANMAT) task force recommendations for the management of patients with mood disorders and comorbid personality disorders
    Michael Rosenbluth
    Toronto East General Hospital Day, Treatment Program, East York, Ontario, Canada
    Ann Clin Psychiatry 24:56-68. 2012
    ..There is a need for recommendations to assist clinicians in treating these frequently encountered patients...
  23. pmc The role of the hippocampus in the pathophysiology of major depression
    Stephanie Campbell
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Psychiatry Neurosci 29:417-26. 2004
    ....
  24. ncbi request reprint Adults with mood disorders have an increased risk profile for cardiovascular disease within the first 2 years of treatment
    Valerie Taylor
    Department of Psychiatry and Behavioural Neuroscience, McMaster University, Hamilton, Ontario, Canada
    Can J Psychiatry 55:362-8. 2010
    ..The objective of our study was to examine patients' physical health prior to first treatment and over 2 years of follow-up...
  25. doi request reprint Impaired theory of mind performance in patients with recurrent bipolar disorder: Moderating effect of cognitive load
    Margaret C McKinnon
    Mood Disorders Program, St Joseph s Healthcare, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Psychiatry Res 177:261-2. 2010
    ..Patients showed impaired performance on cognitively demanding second-order ToM tasks. Reduced ToM performance was associated with longer illness duration, and with increased symptom severity...
  26. doi request reprint Anterior cingulate volumes in never-treated patients with major depressive disorder
    Kaan Yucel
    Mood Disorders Program, St Joseph s Healthcare Hamilton and Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    Neuropsychopharmacology 33:3157-63. 2008
    ..These findings confirm the presence of ACC volume reductions in untreated patients with MDD and suggest that illness burden and short-term medication exposure mediate this change...
  27. ncbi request reprint Coping styles in prodromes of bipolar mania
    Sagar V Parikh
    Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Bipolar Disord 9:589-95. 2007
    ....
  28. ncbi request reprint Neurobiological factors linking personality traits and major depression
    Jane A Foster
    Department of Psychiatry and Behavioural Neurosciences, McMaster University
    Can J Psychiatry 53:6-13. 2008
    ..To examine the neurobiological basis of personality and depression...
  29. ncbi request reprint Longitudinal outcome in patients with bipolar disorder assessed by life-charting is influenced by DSM-IV personality disorder symptoms
    Peter J Bieling
    Mood Disorders Program, Department of Psychiatry and Behavioral Neurosciences, McMaster University and St Joseph s Healthcare, Hamilton, Ontorio, Canada
    Bipolar Disord 5:14-21. 2003
    ..The primary purpose of this paper was to examine the impact of DSM-IV personality disorder symptoms on long-term clinical outcome in BD...
  30. doi request reprint Increased choline-containing compounds in the orbitofrontal cortex and hippocampus in euthymic patients with bipolar disorder: a proton magnetic resonance spectroscopy study
    Rhandi Senaratne
    Department of Psychiatry and Behavioural Neurosciences, Faculty of Health Sciences, McMaster University, F130 301 James Street South, Hamilton, Ontario, Canada L8P 3B6
    Psychiatry Res 172:205-9. 2009
    ..Abnormal neuronal loss within the hippocampus and orbitofrontal cortex further supports previous work suggesting that these regions are involved in the pathophysiology of BD...
  31. ncbi request reprint A pilot study of visual backward masking performance among affected versus unaffected offspring of parents with bipolar disorder
    Glenda M MacQueen
    McMaster University, Hamilton, Ontario, Canada
    Bipolar Disord 6:374-8. 2004
    ..A high-risk paradigm would clarify the temporal relation of cognitive dysfunction to clinical course...
  32. pmc Adult hippocampal neurogenesis reduces memory interference in humans: opposing effects of aerobic exercise and depression
    Nicolas Déry
    Department of Psychology, Neuroscience and Behaviour, McMaster University Hamilton, ON, Canada
    Front Neurosci 7:66. 2013
    ..Taken together, our results support the hypothesis that adult-born neurons in the DG contribute to the orthogonalization of incoming information...
  33. ncbi request reprint An update on regional brain volume differences associated with mood disorders
    Stephanie Campbell
    McMaster University Medical Centre, Hamilton, Ontario, Canada
    Curr Opin Psychiatry 19:25-33. 2006
    ..A systematic search of the literature in English, from January 2004 to July 2005, was performed on MEDLINE. References cited in all reports were searched iteratively to identify missing studies...
  34. ncbi request reprint Associations between bipolar disorder and metabolic syndrome: A review
    Valerie Taylor
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Clin Psychiatry 67:1034-41. 2006
    ....
  35. ncbi request reprint Bilateral hippocampal volume increase in patients with bipolar disorder and short-term lithium treatment
    Kaan Yucel
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    Neuropsychopharmacology 33:361-7. 2008
    ..Our study provides further confirmation that Li can exert structural effects on the HC, which are detectable in vivo. The study emphasizes the need to control for even brief exposure to medication in volumetric studies of the HC...
  36. doi request reprint Hippocampal metabolic abnormalities at first onset and with recurrent episodes of a major depressive disorder: a proton magnetic resonance spectroscopy study
    Andrea Milne
    Department of Psychiatry and Behavioural Neurosciences, Faculty of Health Sciences, McMaster University, St Joseph s Healthcare, Centre for Mountain Health Services, 100 West 5th, Hamilton, Ontario, Canada
    Neuroimage 47:36-41. 2009
    ....
  37. doi request reprint Structural connectivity of visuotopic intraparietal sulcus
    Signe Bray
    Department of Radiology, University of Calgary, Canada
    Neuroimage 82:137-45. 2013
    ....
  38. ncbi request reprint Change in forced expiratory volume in 1 second after sham bronchoconstrictor in suggestible but not suggestion-resistant asthmatic subjects: a pilot study
    Richard Leigh
    Firestone Institute for Respiratory Health R L, F E H and the Brain Body Institute G M, G T, J B, St Joseph s Healthcare, McMaster University, Hamilton, Ontario, Canada
    Psychosom Med 65:791-5. 2003
    ..Literature points to the importance of suggestion in asthma, and we reasoned that patients' level of suggestibility might influence their likelihood of responding to placebo-like suggestion...
  39. ncbi request reprint Neonatal maternal separation predisposes adult rats to colonic barrier dysfunction in response to mild stress
    Johan D Soderholm
    Intestinal Disease Research Program, Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    Am J Physiol Gastrointest Liver Physiol 283:G1257-63. 2002
    ..Our results indicate that neonatal trauma can induce phenotypic changes in adulthood, including enhanced vulnerability of the gut mucosa to stress via mechanisms involving peripherally located CRH receptors...
  40. doi request reprint Altered self-report of empathic responding in patients with bipolar disorder
    Andrée Cusi
    Mood Disorders Program, St Joseph s Healthcare, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Canada
    Psychiatry Res 178:354-8. 2010
    ..Additional studies, involving larger samples, are required to determine the contribution of social cognitive performance to impaired social functioning in BD...
  41. pmc Neuron somal size is decreased in the lateral amygdalar nucleus of subjects with bipolar disorder
    Yarema B Bezchlibnyk
    The Vivian Rakoff Mood Disorders Lab, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Psychiatry Neurosci 32:203-10. 2007
    ..Morphometric studies of postmortem brains from subjects with mood disorders have reported altered density of glial cells in the amygdala; however, the nuclear regions have not been examined individually...
  42. pmc A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder
    Margaret C McKinnon
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Psychiatry Neurosci 34:41-54. 2009
    ..Some, although not all, studies report small hippocampal volume in patients with major depressive disorder (MDD) relative to healthy controls. Here, we explore the contribution of key demographic and clinical variables to this difference...
  43. doi request reprint Increased rates of obesity in first-presentation adults with mood disorders over the course of four-year follow-up
    Valerie Taylor
    McMaster University, Hamilton, ON, Canada
    J Affect Disord 109:127-31. 2008
    ..Patients with mood disorders have higher rates of obesity than the general population. With respect to this, little is known regarding how patient look like prior to treatment or the rates of change...
  44. ncbi request reprint Managing psychiatric disorders with antidiabetic agents: translational research and treatment opportunities
    Roger S McIntyre
    Mood Disorders Psychopharmacology Unit, University Health Network, 399 Bathurst Street Toronto, ON, M5T 2S8, Canada
    Expert Opin Pharmacother 7:1305-21. 2006
    ..Antidiabetic treatments, which maintain euglycaemia, hold promise as potent and clinically significant therapeutic interventions for several neuropsychiatric disorders...
  45. doi request reprint A review of candidate pathways underlying the association between asthma and major depressive disorder
    Ryan J Van Lieshout
    Department of Psychiatry and Behavioural Neurosciences, McMaster University and Brain Body Institute, St Joseph s Healthcare Hamilton, Ontario, Canada
    Psychosom Med 71:187-95. 2009
    ..To consider the mechanisms that may link asthma and major depressive disorder (MDD). Asthma and MDD co-occur at higher rates than expected, but whether this reflects shared underlying pathophysiological mechanisms is not known...
  46. ncbi request reprint Lower hippocampal volume in patients suffering from depression: a meta-analysis
    Stephanie Campbell
    Mood Disorders Program and Department of Radiology, McMaster University, Hamilton, Ontario, Canada
    Am J Psychiatry 161:598-607. 2004
    ..They also examined factors that may contribute to the disparate results in the literature...
  47. ncbi request reprint Previous mood state predicts response and switch rates in patients with bipolar depression
    Glenda M MacQueen
    Mood Disorders Program, McMaster University, Hamilton, Ont, Canada
    Acta Psychiatr Scand 105:414-8. 2002
    ..The treatment of bipolar depression is a significant clinical problem that remains understudied. The role for antidepressant (AD) agents vs. mood stabilizers has been particularly problematic to ascertain...
  48. ncbi request reprint Amygdala cyclic adenosine monophosphate response element binding protein phosphorylation in patients with mood disorders: effects of diagnosis, suicide, and drug treatment
    L Trevor Young
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Biol Psychiatry 55:570-7. 2004
    ..Therefore, we measured the levels of phosphorylated CREB (pCREB) in the amygdala, a region critical to emotional processing and important in the pathophysiology of both BD and MDD...
  49. doi request reprint Electroencephalographic effects of galantamine in major depressive disorder
    Safa A Elgamal
    Department of Kinesiology, Aging and Neurosciences Group, University of Waterloo, Waterloo, Ontario, Canada
    J Clin Neurophysiol 26:192-7. 2009
    ..We recommend the initiation of a larger study to confirm our findings and help in understanding the neuropathology of major depression...
  50. ncbi request reprint Thiazolidinediones: novel treatments for cognitive deficits in mood disorders?
    Roger S McIntyre
    University of Toronto, Department of Psychiatry, Toronto, ON, Canada
    Expert Opin Pharmacother 8:1615-28. 2007
    ..Extant data provide the basis for formulating a hypothesis that TZDs may be salutary for cognitive deficits and several aspects of somatic health (e.g., cardiovascular disease) associated with mood disorders...
  51. ncbi request reprint A prospective, longitudinal study of percentage of time spent ill in patients with bipolar I or bipolar II disorders
    Russell T Joffe
    Department of Psychiatry, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Bipolar Disord 6:62-6. 2004
    ..This study examined time spent in minor and subsyndromal mood states as well as with mania and depression in a cohort of well characterized bipolar I and II patients who were followed prospectively for an average of three years...
  52. ncbi request reprint Does substitution of T4 with T3 plus T4 for T4 replacement improve depressive symptoms in patients with hypothyroidism?
    Russell T Joffe
    Department of Psychiatry, UMDNJ, New Jersey Medical School, Newark, NJ 07103, USA
    Ann N Y Acad Sci 1032:287-8. 2004
    ..Forty individuals were included who had depressive symptoms on stable doses of levothyroxine. Combined T4 plus T3 did not have a significantly different effect on mood and well-being scores than did T4 alone...