A J MacPherson

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi BLySsful interactions between DCs and B cells
    Andrew J Macpherson
    Nat Immunol 3:798-800. 2002
  2. ncbi The immune geography of IgA induction and function
    A J MacPherson
    Department of Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Mucosal Immunol 1:11-22. 2008
  3. ncbi Mesenteric lymph nodes at the center of immune anatomy
    Andrew J Macpherson
    Department of Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Exp Med 203:497-500. 2006
  4. ncbi IgA adaptation to the presence of commensal bacteria in the intestine
    A J MacPherson
    Department of Medicine, McMaster University Medical Center, Room 3N51H, 1200 Main St West, Hamilton Ontario, L8 N 3Z5, Canada
    Curr Top Microbiol Immunol 308:117-36. 2006
  5. ncbi APRIL in the intestine: a good destination for immunoglobulin A(2)
    Andrew J Macpherson
    Department of Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Immunity 26:755-7. 2007
  6. ncbi The functional interactions of commensal bacteria with intestinal secretory IgA
    Andrew J Macpherson
    Department of Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Curr Opin Gastroenterol 23:673-8. 2007
  7. ncbi Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota
    Bärbel Stecher
    Institute of Microbiology, Swiss Institute of Technology Zurich, Zurich, Switzerland
    PLoS Biol 5:2177-89. 2007
  8. ncbi Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota
    Karen Smith
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Semin Immunol 19:59-69. 2007
  9. ncbi Adaptation of solitary intestinal lymphoid tissue in response to microbiota and chemokine receptor CCR7 signaling
    Oliver Pabst
    Institute of Immunology, Hannover Medical School, Hannover, Germany
    J Immunol 177:6824-32. 2006
  10. ncbi Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection
    Kathy D McCoy
    Institute of Experimental Immunology, Department of Pathology, Universitatsspital, CH8091 Zurich, Switzerland
    Cell Host Microbe 4:362-73. 2008

Collaborators

Detail Information

Publications21

  1. ncbi BLySsful interactions between DCs and B cells
    Andrew J Macpherson
    Nat Immunol 3:798-800. 2002
  2. ncbi The immune geography of IgA induction and function
    A J MacPherson
    Department of Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Mucosal Immunol 1:11-22. 2008
    ..We also review the functionality of secretory IgA directed against both commensal organisms and pathogens...
  3. ncbi Mesenteric lymph nodes at the center of immune anatomy
    Andrew J Macpherson
    Department of Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Exp Med 203:497-500. 2006
    ....
  4. ncbi IgA adaptation to the presence of commensal bacteria in the intestine
    A J MacPherson
    Department of Medicine, McMaster University Medical Center, Room 3N51H, 1200 Main St West, Hamilton Ontario, L8 N 3Z5, Canada
    Curr Top Microbiol Immunol 308:117-36. 2006
    ..The secretion of antibodies across the intestinal epithelial surface in turn limits the penetration of commensal organisms, but this is one of many mechanisms which adapt the intestinal mucosa to co-existence with commensal bacteria...
  5. ncbi APRIL in the intestine: a good destination for immunoglobulin A(2)
    Andrew J Macpherson
    Department of Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Immunity 26:755-7. 2007
    ..In this issue, He et al. (2007) find that bacterial molecules promote IgA(2) generation via the cytokine APRIL, produced by intestinal epithelial and dendritic cells...
  6. ncbi The functional interactions of commensal bacteria with intestinal secretory IgA
    Andrew J Macpherson
    Department of Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Curr Opin Gastroenterol 23:673-8. 2007
    ..The aim of this article is to describe the immune geography of IgA induction by commensal intestinal bacteria and the underlying mechanisms of cytokine and costimulatory signalling between dendritic cells, B cells and T cells...
  7. ncbi Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota
    Bärbel Stecher
    Institute of Microbiology, Swiss Institute of Technology Zurich, Zurich, Switzerland
    PLoS Biol 5:2177-89. 2007
    ..Triggering the host's immune defence can shift the balance between the protective microbiota and the pathogen in favour of the pathogen...
  8. ncbi Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota
    Karen Smith
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Semin Immunol 19:59-69. 2007
    ....
  9. ncbi Adaptation of solitary intestinal lymphoid tissue in response to microbiota and chemokine receptor CCR7 signaling
    Oliver Pabst
    Institute of Immunology, Hannover Medical School, Hannover, Germany
    J Immunol 177:6824-32. 2006
    ..In conclusion, our findings establish that intestinal microbes influence the manifestation of gut-associated lymphoid tissues and identify CCR7 signaling as an endogeneous factor that controls this process...
  10. ncbi Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection
    Kathy D McCoy
    Institute of Experimental Immunology, Department of Pathology, Universitatsspital, CH8091 Zurich, Switzerland
    Cell Host Microbe 4:362-73. 2008
    ....
  11. ncbi The armed truce between the intestinal microflora and host mucosal immunity
    Andrew J Macpherson
    Semin Immunol 19:57-8. 2007
  12. ncbi Mechanisms of neonatal mucosal antibody protection
    Nicola L Harris
    Institute of Experimental Immunology, Universitatsspital, Zurich, Switzerland
    J Immunol 177:6256-62. 2006
    ..This immune IgG could either be delivered directly in milk or retrotransported via neonatal Fc receptor from the neonatal serum into the intestinal lumen to exert its protective effect...
  13. ncbi Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria
    Andrew J Macpherson
    Institute of Experimental Immunology, Universitatsspital, Zurich, Switzerland
    Immunology 115:153-62. 2005
    ....
  14. ncbi Compartmentalization of the mucosal immune responses to commensal intestinal bacteria
    Andrew J Macpherson
    Institut für Experimentelle Immunologie, Universitatsspital Zurich, Schmelzbergstrasse, 12, CH8091 Zurich, Switzerland
    Ann N Y Acad Sci 1029:36-43. 2004
    ..In this way the mucosal immune responses to commensals are geographically and functionally separated from systemic immunity...
  15. ncbi Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria
    Andrew J Macpherson
    Institute of Experimental Immunology, Universitatsspital, CH8091 Zurich, Switzerland
    Science 303:1662-5. 2004
    ....
  16. ncbi The donor splice site mutation in NFkappaB-inducing kinase of alymphoplasia (aly/aly) mice
    Andrew J Macpherson
    Institute of Experimental ImmunologyUniversitätsspital, Schmelzbergstrasse 12, 8091 Zurich Switzerland
    Immunogenetics 54:693-8. 2003
    ....
  17. ncbi Overexpression of lymphotoxin in T cells induces fulminant thymic involution
    Mathias Heikenwalder
    Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Am J Pathol 172:1555-70. 2008
    ....
  18. ncbi Long-term maternal imprinting of the specific B cell repertoire by maternal antibodies
    Katja Fink
    Institute of Experimental Immunology, University Hospital Zurich, Zurich, Switzerland
    Eur J Immunol 38:90-101. 2008
    ....
  19. ncbi Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections
    Lukas Hunziker
    Institute for Experimental Immunology, University Hospital, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Nat Immunol 4:343-9. 2003
    ..This nonspecific B cell activation may contribute to antibody-mediated autoimmunity...
  20. ncbi Interactions between commensal intestinal bacteria and the immune system
    Andrew J Macpherson
    Institute of Experimental Immunology, , Schmelzbergstrasse 12, CH8091 Zurich, Switzerland
    Nat Rev Immunol 4:478-85. 2004
  21. ncbi Comparison of Salmonella enterica serovar Typhimurium colitis in germfree mice and mice pretreated with streptomycin
    Bärbel Stecher
    Institute of Microbiology, ETH Zurich, Wolfgang Paulistrasse 10, HCI G413, CH 8093 Zurich, Switzerland
    Infect Immun 73:3228-41. 2005
    ..One obvious difference was more pronounced damage and reduced regenerative response of the cecal epithelium in GF mice. Overall, StrSPF mice and GF mice provide similar but not identical models for Salmonella serovar Typhimurium colitis...