Mark B Loeb

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. pmc Application of the development stages of a cluster randomized trial to a framework for valuating complex health interventions
    Mark B Loeb
    Department of Pathology, McMaster University, Hamilton, Ontario, Canada
    BMC Health Serv Res 2:13. 2002
  2. ncbi request reprint Epidemiology of community- and nursing home-acquired pneumonia in older adults
    Mark Loeb
    McMaster University, Hamilton, Ontario, Canada
    Expert Rev Anti Infect Ther 3:263-70. 2005
  3. ncbi request reprint Pneumonia in nursing homes and long-term care facilities
    Mark B Loeb
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Semin Respir Crit Care Med 26:650-5. 2005
  4. pmc Nursing home residents and Enterobacteriaceae resistant to third-generation cephalosporins
    Carolyn Sandoval
    McMaster University, Hamilton, Ontario, Canada
    Emerg Infect Dis 10:1050-5. 2004
  5. pmc Pandemic (H1N1) 2009 Risk for Nurses after Trivalent Vaccination
    Mark Loeb
    McMaster University, Hamilton, Ontario, Canada M Loeb, D J D Earn, M Smieja and St Jude Children s Research Hospital, Memphis, Tennessee, USA R Webby
    Emerg Infect Dis 16:719-20. 2010
  6. doi request reprint Populations at risk for severe or complicated Avian Influenza H5N1: a systematic review and meta-analysis
    Dominik Mertz
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada Michael G DeGroote Institute for Infectious Diseases Research, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 9:e89697. 2014
  7. doi request reprint Serum 25-hydroxyvitamin d level and influenza vaccine immunogenicity in children and adolescents
    Michelle Science
    Division of Infectious Diseases, The Hospital for Sick Children, Toronto, Ontario, Canada Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 9:e83553. 2014
  8. pmc Populations at risk for severe or complicated influenza illness: systematic review and meta-analysis
    Dominik Mertz
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    BMJ 347:f5061. 2013
  9. pmc Vaccine herd effect
    Tae Hyong Kim
    Department of Pathology and Molecular Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada
    Scand J Infect Dis 43:683-9. 2011
  10. ncbi request reprint Newcastle-Ottawa Scale: comparing reviewers' to authors' assessments
    Carson Ka Lok Lo
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton Ontario, Canada
    BMC Med Res Methodol 14:45. 2014

Detail Information

Publications95

  1. pmc Application of the development stages of a cluster randomized trial to a framework for valuating complex health interventions
    Mark B Loeb
    Department of Pathology, McMaster University, Hamilton, Ontario, Canada
    BMC Health Serv Res 2:13. 2002
    ..In so doing, the utility of the framework for health services researchers is evaluated...
  2. ncbi request reprint Epidemiology of community- and nursing home-acquired pneumonia in older adults
    Mark Loeb
    McMaster University, Hamilton, Ontario, Canada
    Expert Rev Anti Infect Ther 3:263-70. 2005
    ..There is a reduced prevalence of nonrespiratory symptoms in this age group. Advanced age and comorbidity are important prognostic factors. Influenza and pneumococcal vaccination remain the key factors for prevention...
  3. ncbi request reprint Pneumonia in nursing homes and long-term care facilities
    Mark B Loeb
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Semin Respir Crit Care Med 26:650-5. 2005
    ..There are key management issues, such as site of care, which remain unresolved. Immunization with influenza and pneumococcal vaccines remains the mainstay of prevention...
  4. pmc Nursing home residents and Enterobacteriaceae resistant to third-generation cephalosporins
    Carolyn Sandoval
    McMaster University, Hamilton, Ontario, Canada
    Emerg Infect Dis 10:1050-5. 2004
    ..2 to 13.6) and log percentage of residents using gastrostomy tubes within the nursing home (adjusted OR 3.9, 95% CI 1.3 to 12.0) were associated with having a clinical isolate resistant to third-generation cephalosporins...
  5. pmc Pandemic (H1N1) 2009 Risk for Nurses after Trivalent Vaccination
    Mark Loeb
    McMaster University, Hamilton, Ontario, Canada M Loeb, D J D Earn, M Smieja and St Jude Children s Research Hospital, Memphis, Tennessee, USA R Webby
    Emerg Infect Dis 16:719-20. 2010
    ..2%) persons in the surgical mask group and 62 (28.1%) persons in the N95 respirator group had received the 2008-2009 trivalent inactivated influenza vaccine. The nurses were monitored from January 12, 2009, through April 23, 2009...
  6. doi request reprint Populations at risk for severe or complicated Avian Influenza H5N1: a systematic review and meta-analysis
    Dominik Mertz
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada Michael G DeGroote Institute for Infectious Diseases Research, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 9:e89697. 2014
    ..Understanding risk factors is an important step for prioritizing prophylaxis or treatment in the event of a pandemic...
  7. doi request reprint Serum 25-hydroxyvitamin d level and influenza vaccine immunogenicity in children and adolescents
    Michelle Science
    Division of Infectious Diseases, The Hospital for Sick Children, Toronto, Ontario, Canada Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 9:e83553. 2014
    ..The purpose of this study was to determine if serum 25(OH)D level correlates with influenza vaccine immunogenicity in children and adolescents...
  8. pmc Populations at risk for severe or complicated influenza illness: systematic review and meta-analysis
    Dominik Mertz
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    BMJ 347:f5061. 2013
    ..To evaluate risk factors for severe outcomes in patients with seasonal and pandemic influenza...
  9. pmc Vaccine herd effect
    Tae Hyong Kim
    Department of Pathology and Molecular Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada
    Scand J Infect Dis 43:683-9. 2011
    ..A high uptake of vaccines is generally needed for success. In this paper we aim to provide an update review on the herd effect, focusing on the clinical benefit, by reviewing data for specific vaccines...
  10. ncbi request reprint Newcastle-Ottawa Scale: comparing reviewers' to authors' assessments
    Carson Ka Lok Lo
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton Ontario, Canada
    BMC Med Res Methodol 14:45. 2014
    ....
  11. pmc Comparing influenza vaccine efficacy against mismatched and matched strains: a systematic review and meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    BMC Med 11:153. 2013
    ..However, antigens contained in the vaccines do not always match circulating strains. In the present work we aimed to examine the vaccine efficacy (VE) afforded by influenza vaccines when they are not well matched to circulating strains...
  12. doi request reprint Genetic susceptibility to West Nile virus and dengue
    M Loeb
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ont, Canada
    Public Health Genomics 16:4-8. 2013
    ..The text below not only summarizes the genetic factors that predispose to complications of these 2 important flaviviruses, but also illustrates the challenges in determining the genomic basis for complications to these viruses...
  13. pmc Effect of influenza vaccines against mismatched strains: a systematic review protocol
    Andrea C Tricco
    McMaster University, Room 3203, 1200 Main Street West, Hamilton, Ontario, Canada
    Syst Rev 1:35. 2012
    ..We propose to systematically review the cross-protection offered by influenza vaccines against circulating influenza A or B viruses that are not antigenically well-matched to vaccine strains...
  14. ncbi request reprint Longitudinal study of influenza molecular viral shedding in Hutterite communities
    Mark Loeb
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Infect Dis 206:1078-84. 2012
    ..The nature of influenza viral shedding during naturally acquired infection is not well understood...
  15. pmc Protocol: transmission and prevention of influenza in Hutterites: zoonotic transmission of influenza A: swine & swine workers
    Margaret L Russell
    Department of Community Health Sciences, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    BMC Public Health 9:420. 2009
    ..This project also includes non-Hutterite swine farms that are experiencing swine respiratory illness...
  16. pmc Lack of association between vascular dementia and Chlamydia pneumoniae infection: a case-control study
    Soo Chan Carusone
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main St W, L8N 3Z5 Hamilton, Canada
    BMC Neurol 4:15. 2004
    ..pneumoniae may play a role in vascular dementia. The objective of this study was to determine if there was an association between serological evidence of C. pneumoniae infection or inflammatory markers with vascular dementia...
  17. pmc Predictors of pneumococcal vaccination among older adults with pneumonia: findings from the Community Acquired Pneumonia Impact Study
    Paul Krueger
    Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada
    BMC Geriatr 10:44. 2010
    ..The purpose of this study was to identify predictors of pneumococcal vaccination among community-dwelling older adults with clinically diagnosed CAP...
  18. pmc Hospitalization and emergency department visits among seniors receiving homecare: a pilot study
    Andrew A Smith
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
    BMC Geriatr 5:9. 2005
    ..In order to determine the feasibility of a large-scale study, we conducted a pilot study to assess utilization of acute health care services among seniors receiving homecare to determine associated clinical outcomes...
  19. pmc Predictors of inhospital mortality and re-hospitalization in older adults with community-acquired pneumonia: a prospective cohort study
    Binod Neupane
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    BMC Geriatr 10:22. 2010
    ..We aimed to assess the associations of potentially modifiable factors with mortality and re-hospitalization in older adults hospitalized with community-acquired pneumonia...
  20. pmc Predictors of health decline in older adults with pneumonia: findings from the Community Acquired Pneumonia Impact Study
    Eduardo Fernandez
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    BMC Geriatr 10:1. 2010
    ..It was hypothesized that older adults with CAP who had lower levels of social support would be more likely to report a decline in health...
  21. pmc Pneumonia care and the nursing home: a qualitative descriptive study of resident and family member perspectives
    Soo Chan Carusone
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    BMC Geriatr 6:2. 2006
    ..This qualitative study examined resident and family member perspectives on in situ care for pneumonia...
  22. pmc "I really should've gone to the doctor": older adults and family caregivers describe their experiences with community-acquired pneumonia
    Caralyn Kelly
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    BMC Fam Pract 7:30. 2006
    ..The primary objective of this study was to describe how community-dwelling older adults and their family members responded to symptoms of community-acquired pneumonia (CAP)...
  23. pmc Assessing, treating and preventing community acquired pneumonia in older adults: findings from a community-wide survey of emergency room and family physicians
    Paul Krueger
    St, Joseph s Health System Research Network, Father Sean O Sullivan Research Centre, Hamilton, Ontario, Canada
    BMC Fam Pract 6:32. 2005
    ....
  24. ncbi request reprint Effect of a clinical pathway to reduce hospitalizations in nursing home residents with pneumonia: a randomized controlled trial
    Mark Loeb
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    JAMA 295:2503-10. 2006
    ..Nursing home residents with pneumonia are frequently hospitalized. Such transfers may be associated with multiple hazards of hospitalization as well as economic costs...
  25. ncbi request reprint Interobserver reliability of radiologists' interpretations of mobile chest radiographs for nursing home-acquired pneumonia
    Mark B Loeb
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Am Med Dir Assoc 7:416-9. 2006
    ..To determine the interobserver reliability of radiologists' interpretations of mobile chest radiographs for nursing home-acquired pneumonia...
  26. doi request reprint Effect of influenza vaccination of children on infection rates in Hutterite communities: a randomized trial
    Mark Loeb
    Department of Pathology and Molecular Medicine, McMaster University, 1200 Main St W, Hamilton, ON, L8N 3Z5 Canada
    JAMA 303:943-50. 2010
    ..Children and adolescents appear to play an important role in the transmission of influenza. Selectively vaccinating youngsters against influenza may interrupt virus transmission and protect those not immunized...
  27. pmc Stop orders to reduce inappropriate urinary catheterization in hospitalized patients: a randomized controlled trial
    Mark Loeb
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Gen Intern Med 23:816-20. 2008
    ..Hospitalized patients frequently have urinary catheters inserted for inappropriate reasons. This can lead to urinary tract infections and other complications...
  28. pmc Genetic variants and susceptibility to neurological complications following West Nile virus infection
    Mark Loeb
    Department of Medicine, Clinical Epidemiology, and Biostatistics, McMaster University, Hamilton, Ontario
    J Infect Dis 204:1031-7. 2011
    ..0022; rs2298771, P = .005; rs25651, P = .042. Using mostly nonsynonymous variants, we therefore did not identify genetic variants associated with neuroinvasive disease...
  29. ncbi request reprint Prognosis after West Nile virus infection
    Mark Loeb
    McMaster University, MDCL 3200, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Ann Intern Med 149:232-41. 2008
    ..The long-term prognosis of patients infected with West Nile virus is not well understood...
  30. doi request reprint Environmental risk factors for community-acquired pneumonia hospitalization in older adults
    Mark Loeb
    Departments of Pathology and Molecular Medicine, McMaster University, MDCL 3200, 1200 Main St W, Hamilton, ON L8N 3Z5, Canada
    J Am Geriatr Soc 57:1036-40. 2009
    ..To investigate the risk of hospitalization for pneumonia in older adults in relation to biophysical environmental factors...
  31. pmc Protective behavior and West Nile virus risk
    Mark Loeb
    McMaster University, Hamilton, Ontario, Canada
    Emerg Infect Dis 11:1433-6. 2005
    ..Practicing > or =2 personal protective behavior traits reduced the risk for WNV infection by half...
  32. pmc Effect of a multifaceted intervention on number of antimicrobial prescriptions for suspected urinary tract infections in residents of nursing homes: cluster randomised controlled trial
    Mark Loeb
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    BMJ 331:669. 2005
    ..To assess whether a multifaceted intervention can reduce the number of prescriptions for antimicrobials for suspected urinary tract infections in residents of nursing homes...
  33. pmc Antibiotic use in Ontario facilities that provide chronic care
    M Loeb
    Division of Microbiology, Department of Pathology, McMaster University, Hamilton, Ontario, Canada
    J Gen Intern Med 16:376-83. 2001
    ..To determine the incidence and variability of antibiotic use in facilities which provide chronic care and to determine how often clinical criteria for infection are met when antibiotics are prescribed in these facilities...
  34. ncbi request reprint Community-acquired pneumonia in older people: the need for a broader perspective
    Mark B Loeb
    Department of Pathology and Molecular Medicine and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Am Geriatr Soc 51:539-43. 2003
    ..Determining the effect of air pollution on CAP in older adults is important in terms of reducing personal risk to older individuals and for healthcare agencies charged with formulating policy to protect the health of older adults...
  35. ncbi request reprint Interventions to prevent aspiration pneumonia in older adults: a systematic review
    Mark B Loeb
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Am Geriatr Soc 51:1018-22. 2003
    ..Considering how common the problem of AP is in older adults, larger, high-quality RCTs on the effectiveness of preventive interventions are warranted...
  36. ncbi request reprint Pneumonia in older persons
    Mark Loeb
    Department of Pathology, McMaster University, Hamilton, Ontario, Canada
    Clin Infect Dis 37:1335-9. 2003
    ..Although evidence in clinical trials differs from evidence in observational studies that demonstrate clear benefits associated with the polysaccharide pneumococcal vaccine in this population, the vaccine is recommended for adults aged..
  37. ncbi request reprint A randomized, controlled trial of doxycycline and rifampin for patients with Alzheimer's disease
    Mark B Loeb
    Department of Pathology and Molecular Medicine, Biostatistics Hamilton Regional Laboratory Medicine Program, Hamilton, Ontario, Canada
    J Am Geriatr Soc 52:381-7. 2004
    ..To assess whether doxycycline and rifampin have a therapeutic role in patients with Alzheimer's disease (AD)...
  38. ncbi request reprint Pneumonia in the elderly
    Mark Loeb
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Curr Opin Infect Dis 17:127-30. 2004
    ..This review provides an update on new data about the etiology, clinical characteristics, outcomes, and prevention of community-acquired pneumonia. The impact of severe acute respiratory syndrome in older persons is also addressed...
  39. pmc SARS among critical care nurses, Toronto
    Mark Loeb
    Department of Pathology and Molecualr Medicine, McMaster University, Hamilton, Ontario, Canada
    Emerg Infect Dis 10:251-5. 2004
    ..Risk was lower with consistent use of a N95 mask than with consistent use of a surgical mask. We conclude that activities related to intubation increase SARS risk and use of a mask (particularly a N95 mask) is protective...
  40. ncbi request reprint Use of a broader determinants of health model for community-acquired pneumonia in seniors
    Mark B Loeb
    Department of Pathology, McMaster University, Hamilton, Ontario, Canada
    Clin Infect Dis 38:1293-7. 2004
    ..Although the causal pathways may be unclear, there are data to suggest a relationship between low socioeconomic status and risk of acquiring respiratory infection. The need for more research in this area is emphasized...
  41. ncbi request reprint Risk factors for resistance to antimicrobial agents among nursing home residents
    Mark B Loeb
    Department of Pathology and Molecular Medicine, McMaster University and Hamilton Regional Laboratory Program, Hamilton, Ontario, Canada
    Am J Epidemiol 157:40-7. 2003
    ..08, 95% CI: 1.04, 1.11), respectively. These findings suggest that increased staffing, more hand-washing sinks, and use of antimicrobial soap may reduce resistance to antimicrobial agents in long-term care facilities...
  42. pmc Optimizing antibiotics in residents of nursing homes: protocol of a randomized trial
    Mark Loeb
    Department of Pathology and Molecular Medicine, McMaster University Hamilton, ON, Canada
    BMC Health Serv Res 2:17. 2002
    ..This proposal describes a randomized trial of diagnostic and therapeutic algorithms to reduce the use of antibiotics in residents of long-term care facilities...
  43. ncbi request reprint The effect of malnutrition on risk and outcome of community-acquired pneumonia
    Mark Loeb
    Department of Pathology and Molecular Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L8, Canada
    Respir Care Clin N Am 11:99-108. 2005
    ..The elderly population is particularly vulnerable. There is a relative lack of data on the effect of nutrition on risk and outcome of CAP. More research is needed to better delineate the impact of nutrition on risk and outcome of CAP...
  44. ncbi request reprint Adherence to antibiotic guidelines for pneumonia in chronic-care facilities in Ontario
    M Loeb
    Division of Medical Microbiology and Infectious Diseases, McMaster University and the Hamilton Regional Laboratory Program, Ont
    Clin Invest Med 24:304-10. 2001
    ..To evaluate adherence to antibiotic recommendations for the treatment of pneumonia in patients who receive long-term care and to assess outcomes associated with these recommendations...
  45. doi request reprint Comparison of multiple estimates of efficacy for influenza vaccine
    Mark Loeb
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Vaccine 30:1-4. 2011
    ..Such data reveal variance in protective efficacy of the vaccine for multi-dimensional direct and indirect efficacy measures...
  46. ncbi request reprint A clinical pathway for treating pneumonia in the nursing home: part I: the nursing perspective
    Soo Chan Carusone
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    J Am Med Dir Assoc 7:271-8. 2006
    ..This paper examines nursing staff's perspectives on the utility and sustainability of a clinical pathway for treating nursing home residents with pneumonia...
  47. ncbi request reprint A clinical pathway for treating pneumonia in the nursing home: part II: the administrators' perspective and how it differs from nurses' views
    Soo Chan Carusone
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    J Am Med Dir Assoc 7:279-86. 2006
    ..The discussion includes a comparison of the perspectives of the administrators and the nursing staff (reported in part I of this article)...
  48. pmc The polyfunctionality of human memory CD8+ T cells elicited by acute and chronic virus infections is not influenced by age
    Alina Lelic
    McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    PLoS Pathog 8:e1003076. 2012
    ....
  49. ncbi request reprint Pneumonia and lower respiratory infections in nursing home residents: predictors of hospitalization and mortality
    Soo B Chan Carusone
    Departments of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Am Geriatr Soc 55:414-9. 2007
    ..To compare predictors of hospitalization and death in nursing home residents with pneumonia and other lower respiratory infections (LRIs)...
  50. doi request reprint Deciphering epitope specificities within polyserum using affinity selection of random peptides and a novel algorithm based on pattern recognition theory
    Dimitri A Denisov
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Mol Immunol 46:429-36. 2009
    ..This novel algorithm provides the basis for further development of methods to characterize the breadth of epitope recognition within a complex pool of antibodies...
  51. ncbi request reprint Adverse effects of amantadine and oseltamivir used during respiratory outbreaks in a center for developmentally disabled adults
    Allison J McGeer
    Department of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Infect Control Hosp Epidemiol 25:955-61. 2004
    ..We studied the severity of illness due to influenza among adults residing in a center for the developmentally disabled and assessed adverse reactions to amantadine and oseltamivir prophylaxis...
  52. doi request reprint Long-term exposure to ambient air pollution and risk of hospitalization with community-acquired pneumonia in older adults
    Binod Neupane
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 181:47-53. 2010
    ..Little is known about the long-term effects of air pollution on pneumonia hospitalization in the elderly...
  53. pmc Comparing estimates of influenza-associated hospitalization and death among adults with congestive heart failure based on how influenza season is defined
    Carolyn Sandoval
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    BMC Public Health 8:59. 2008
    ..The objective of this study was to compare estimates of influenza-associated risk in a defined clinical population using four different methods of defining the influenza season...
  54. pmc Antimicrobial susceptibilities of health care-associated and community-associated strains of methicillin-resistant Staphylococcus aureus from hospitalized patients in Canada, 1995 to 2008
    Andrew E Simor
    Department of Microbiology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Antimicrob Agents Chemother 54:2265-8. 2010
    ..Reduced susceptibility to glycopeptides was not identified...
  55. ncbi request reprint Modeling transmission of methicillin-resistant Staphylococcus aureus among patients admitted to a hospital
    Janet Raboud
    Department of Public Health Sciences, University of Toronto, and University Health Network, Toronto, Ontario, Canada
    Infect Control Hosp Epidemiol 26:607-15. 2005
    ..To determine the impact of the screening test, nursing workload, handwashing rates, and dependence of handwashing on risk level of patient visit on methicillin-resistant Staphylococcus aureus (MRSA) transmission among hospitalized patients...
  56. doi request reprint Effects of school closure on incidence of pandemic influenza in Alberta, Canada
    David J D Earn
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 156:173-81. 2012
    ..However, investigations of the extent to which these measures actually affect the progression of a pandemic have been limited...
  57. ncbi request reprint Oseltamivir for treatment of influenza in healthy adults: pooled trial evidence and cost-effectiveness model for Canada
    Bernie J O'Brien
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Value Health 6:116-25. 2003
    ..Oseltamivir (Tamiflu) is a neuraminidase inhibitor-a new class of antiviral treatment for influenza where efficacy and safety has been established but cost-effectiveness is unknown...
  58. doi request reprint Surgical mask vs N95 respirator for preventing influenza among health care workers: a randomized trial
    Mark Loeb
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    JAMA 302:1865-71. 2009
    ..Given the likelihood that N95 respirators will be in short supply during a pandemic and not available in many countries, knowing the effectiveness of the surgical mask is of public health importance...
  59. pmc Performance and Cost evaluation of one commercial and six in-house conventional and real-time reverse transcription-pcr assays for detection of severe acute respiratory syndrome coronavirus
    James B Mahony
    McMaster University, Toronto, Ontario L8N 4A6, Canada
    J Clin Microbiol 42:1471-6. 2004
    ..The commercial assay cost was considerably higher at $40.37 per test. The results demonstrated good performance for all assays, providing laboratories that need to do SARS RNA testing with a choice of assay formats...
  60. ncbi request reprint Heeding the message? Determinants of risk behaviours for West Nile virus
    Susan J Elliott
    Faculty of Social Sciences, McMaster University, Hamilton, ON
    Can J Public Health 99:137-41. 2008
    ..This paper evaluates the uptake of the public health message in a WNv hot spot (2002) in order to assess the determinants of the likelihood of undertaking personal protective behaviours to reduce the risk of illness from WNv...
  61. ncbi request reprint Evidence-based clinical pathways to manage urinary tract infections in long-term care facilities: a qualitative case study describing administrator and nursing staff views
    Lynne Lohfeld
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    J Am Med Dir Assoc 8:477-84. 2007
    ..This article examines the views of nursing staff and administrators in long-term care facilities (LTCFs) regarding a clinical pathway for managing urinary tract infections (UTIs) in LTCF residents...
  62. ncbi request reprint A point prevalence survey of health care-associated infections in pediatric populations in major Canadian acute care hospitals
    Denise Gravel
    Centre for Infectious Disease Prevention and Control, Public Health Agency of Canada, Ottawa, ON, Canada
    Am J Infect Control 35:157-62. 2007
    ..To estimate the prevalence of pediatric health care-associated infections (HAI) in Canadian acute care hospitals...
  63. ncbi request reprint Adverse events associated with high-dose ribavirin: evidence from the Toronto outbreak of severe acute respiratory syndrome
    Matthew P Muller
    Department of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Pharmacotherapy 27:494-503. 2007
    ..To distinguish adverse events related to ribavirin therapy from those attributable to severe acute respiratory syndrome (SARS), and to determine the rate of potential ribavirin-related adverse events...
  64. ncbi request reprint Pneumococcal immunization in older adults: implications for the long-term-care setting
    Mark Loeb
    Department of Clinical Epidemiology and Biostatistics, McMaster University and Hamilton Regional Laboratory Program, Hamilton, Ontario, Canada
    Infect Control Hosp Epidemiol 25:985-94. 2004
    ..To compare the efficacy of the polysaccharide pneumococcal vaccine in older adults between clinical trial and observational studies and to discuss the implications for long-term-care facilities (LTCFs)...
  65. ncbi request reprint The memory T cell response to West Nile virus in symptomatic humans following natural infection is not influenced by age and is dominated by a restricted set of CD8+ T cell epitopes
    Robin Parsons
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Immunol 181:1563-72. 2008
    ..These data provide important new insight into the T cell response against WNV in humans...
  66. doi request reprint Community controls were preferred to hospital controls in a case-control study where the cases are derived from the hospital
    Binod Neupane
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Clin Epidemiol 63:926-31. 2010
    ..For hospital cases, we examined how inferences drawn from a case-control study can differ by choice of hospital- vs. community-based controls...
  67. ncbi request reprint One-year outcomes and health care utilization in survivors of severe acute respiratory syndrome
    Catherine M Tansey
    Department of Medicine, University Health Network, and Mount Sinai Hospital, Toronto, Ontario, Canada
    Arch Intern Med 167:1312-20. 2007
    ..Research conducted during the SARS outbreak may help inform research planning for future public health emergencies. The objective of this study was to evaluate the 1-year outcomes in survivors of SARS and their family caregivers...
  68. pmc Prognosis of West Nile virus associated acute flaccid paralysis: a case series
    Jennie Johnstone
    Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada
    J Med Case Reports 5:395. 2011
    ..abstract:..
  69. pmc A novel computer algorithm improves antibody epitope prediction using affinity-selected mimotopes: a case study using monoclonal antibodies against the West Nile virus E protein
    Galina F Denisova
    Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Mol Immunol 46:125-34. 2008
    ..Our results demonstrate that the combination of these two prediction strategies provides a robust platform for epitope characterization...
  70. doi request reprint Health care-associated Clostridium difficile infection in adults admitted to acute care hospitals in Canada: a Canadian Nosocomial Infection Surveillance Program Study
    Denise Gravel
    Centre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, Ontario, Canada
    Clin Infect Dis 48:568-76. 2009
    ..We re-examined the incidence of HA CDI with an emphasis on patient outcomes...
  71. doi request reprint Compliance with personal precautions against exposure to bloodborne pathogens among laboratory workers: a Canadian survey
    Cheryl L Main
    Department of Pathology and Molecular Medicine, McMaster University, Canada
    Infect Control Hosp Epidemiol 29:66-8. 2008
    ..Laboratory workers reported high rates of exposure to bodily fluids and poor rates of compliance with personal protective behaviors. This national study has identified several deficiencies and strategies for improvement...
  72. doi request reprint Hand hygiene practices of health care workers in long-term care facilities
    Andrew Smith
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Infect Control 36:492-4. 2008
    ..Overall hand hygiene adherence was 14.7%, with a mean handwashing time of 15.9 seconds. Adherence varied by activity performed and the presence or absence of a sink...
  73. doi request reprint Surveillance for healthcare-acquired febrile respiratory infection in pediatric hospitals participating in the Canadian Nosocomial Infection Surveillance Program
    Joseph V Vayalumkal
    Canadian Field Epidemiology Program, Public Health Agency of Canada, Ottawa, Ontario, Canada
    Infect Control Hosp Epidemiol 30:652-8. 2009
    ....
  74. doi request reprint Vancomycin-resistant enterococci in Canada: results from the Canadian nosocomial infection surveillance program, 1999-2005
    Marianna Ofner-Agostini
    Centre for Infectious Disease Prevention and Control, Public Health Agency of Canada, Ottawa, Sunnybrook Health Sciences Centre, Hospital for Sick Children, Toronto, Ontario, Canada
    Infect Control Hosp Epidemiol 29:271-4. 2008
    ..Although the incidence rate of VRE carriage in Canada is increasing, it remains very low...
  75. ncbi request reprint Clinical and epidemiologic features of methicillin-resistant Staphylococcus aureus in elderly hospitalized patients
    Andrew E Simor
    Department of Microbiology, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Infect Control Hosp Epidemiol 26:838-41. 2005
    ..The epidemiology and clinical features of these patients is distinct from that of younger patients...
  76. ncbi request reprint Patterns of handwashing behavior and visits to patients on a general medical ward of healthcare workers
    Janet Raboud
    Department of Public Health Sciences, University of Toronto and the University Health Network, Toronto, Ontario, Canada
    Infect Control Hosp Epidemiol 25:198-202. 2004
    ..To obtain accurate data regarding the handwashing behavior and patterns of visits to patients by healthcare workers (HCWs)...
  77. ncbi request reprint Community-acquired pneumonia
    Mark Loeb
    McMaster University, Hamilton, Canada
    Am Fam Physician 66:135-7. 2002
  78. pmc Detection and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates in Canada: results from the Canadian Nosocomial Infection Surveillance Program, 1995-2006
    Heather J Adam
    Department of Laboratory Medicine and Pathobiology, University of Toronto, and Hospital for Sick Children, Toronto, Ontario, Canada
    Antimicrob Agents Chemother 54:945-9. 2010
    ..0; 95% CI, 1.2 to 7.4). There has been no evidence of vancomycin "MIC creep" in Canadian strains of methicillin (meticillin)-resistant S. aureus, and hVISA strains are currently uncommon...
  79. doi request reprint DO IT Trial: vitamin D Outcomes and Interventions in Toddlers - a TARGet Kids! randomized controlled trial
    Jonathon L Maguire
    The Applied Health Research Centre of the Li Ka Shing Knowledge Institute of St, Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    BMC Pediatr 14:37. 2014
    ....
  80. pmc Interferon-mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome
    Mark J Cameron
    Division of Experimental Therapeutics, University Health Network, MaRS Centre, 3 916 TMDT, 101 College Street, Toronto, Ontario, Canada
    J Virol 81:8692-706. 2007
    ....
  81. ncbi request reprint Improving adherence to hand hygiene among health care workers
    Courtney Maskerine
    Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    J Contin Educ Health Prof 26:244-51. 2006
    ..Coherent and methodologically sound research is required to better understand the factors contributing to hand-hygiene behavior among health care professionals...
  82. ncbi request reprint Implementation of the Canadian contingency plan for a case of suspected viral hemorrhagic fever
    Mark Loeb
    Department of Pathology, McMaster University, Hamilton, Ontario, Canada
    Infect Control Hosp Epidemiol 24:280-3. 2003
    ..To describe the implementation of the Canadian contingency plan for viral hemorrhagic fever (VHF) in response to a suspected case...
  83. doi request reprint Infection control practices related to Clostridium difficile infection in acute care hospitals in Canada
    Denise Gravel
    Centre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ontario, Canada
    Am J Infect Control 37:9-14. 2009
    ..We carried out a survey to identify the infection prevention and control practices in place in Canadian hospitals participating in the Canadian Nosocomial Infection Surveillance Program (CNISP)...
  84. pmc Risk factors for SARS transmission from patients requiring intubation: a multicentre investigation in Toronto, Canada
    Janet Raboud
    Division of Infectious Diseases, University Health Network, Toronto, Ontario, Canada
    PLoS ONE 5:e10717. 2010
    ..Considerable controversy resulted regarding which procedures and behaviours were associated with the greatest risk of SARS-CoV transmission...
  85. ncbi request reprint Facility-level correlates of antimicrobial use in nursing homes
    Mark Loeb
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Infect Control Hosp Epidemiol 25:173-6. 2004
    ....
  86. ncbi request reprint Methicillin-resistant Staphylococcus aureus in Canadian aboriginal people
    Marianna Ofner-Agostini
    Centre for Infectious Disease Prevention and Control, Public Health Agency of Canada, Ottawa, Ontario, Canada
    Infect Control Hosp Epidemiol 27:204-7. 2006
    ....
  87. ncbi request reprint Implementation of evidence-based practices for surgical site infection prophylaxis: results of a pre- and postintervention study
    Shawn S Forbes
    Department of Surgery, Division of General Surgery, McMaster University, Hamilton, Ontario, Canada
    J Am Coll Surg 207:336-41. 2008
    ..This study was designed to assess the safety and feasibility of implementing evidence-based care practices to prevent SSIs...
  88. doi request reprint Methicillin-resistant Staphylococcus aureus colonization or infection in Canada: National Surveillance and Changing Epidemiology, 1995-2007
    Andrew E Simor
    Department of Microbiology, Sunnybrook Health Sciences Centre, Hospital for Sick Children, Toronto, Ontario, Canada
    Infect Control Hosp Epidemiol 31:348-56. 2010
    ..To determine the incidence and describe the changing epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) colonization or infection in Canadian hospitals from 1995-2007...
  89. ncbi request reprint Antimicrobials for right-sided endocarditis in intravenous drug users: a systematic review
    Derek Yung
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Antimicrob Chemother 60:921-8. 2007
    ..We sought to systematically review the evidence for obtaining clinical cure with antimicrobials in intravenous drug users (IVDUs) with isolated native valve RSE...
  90. doi request reprint Predicting personal nitrogen dioxide exposure in an elderly population: integrating residential indoor and outdoor measurements, fixed-site ambient pollution concentrations, modeled pollutant levels, and time-activity patterns
    Talar Sahsuvaroglu
    AECOM, Markham, Ontario, Canada
    J Toxicol Environ Health A 72:1520-33. 2009
    ....
  91. ncbi request reprint Severe acute respiratory syndrome: preparedness, management, and impact
    Mark B Loeb
    Infect Control Hosp Epidemiol 25:1017-9. 2004
  92. ncbi request reprint Nursing home-acquired pneumonia: an emergency department treatment algorithm
    Robert R Muder
    University of Pittsburgh and Division of Infectious Diseases, VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
    Curr Med Res Opin 20:1309-20. 2004
    ..It is hoped the NHAP treatment algorithm will contribute to improved outcomes...
  93. ncbi request reprint Older adults who reside in long-term care facilities: a high- risk population for invasive pneumococcal disease
    Mark B Loeb
    J Am Geriatr Soc 51:1669-70. 2003

Research Grants2

  1. A randomized trial of influenza vaccination of Hutterite children
    Mark Loeb; Fiscal Year: 2006
    ..We believe that the trial we propose will lead to important data that can inform policy on influenza immunization strategy. ..