Wendy Lim

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint Meta-analysis: anticoagulant prophylaxis to prevent symptomatic venous thromboembolism in hospitalized medical patients
    Francesco Dentali
    McMaster University and St Joseph s Healthcare, Hamilton, Ontario, Canada
    Ann Intern Med 146:278-88. 2007
  2. ncbi request reprint Antiphospholipid antibiodies: a critical review of the literature
    Wendy Lim
    St Joseph s Hospital, Hamilton, Ontario, Canada
    Curr Opin Hematol 14:494-9. 2007
  3. doi request reprint Using low molecular weight heparin in special patient populations
    Wendy Lim
    Department of Medicine, Division of Hematology Thromboembolism, McMaster University, St Joseph s Hospital, 50 Charlton Avenue East, Hamilton, ON, L8N 4A6, Canada
    J Thromb Thrombolysis 29:233-40. 2010
  4. doi request reprint Complement and the antiphospholipid syndrome
    Wendy Lim
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Curr Opin Hematol 18:361-5. 2011
  5. ncbi request reprint Meta-analysis: low-molecular-weight heparin and bleeding in patients with severe renal insufficiency
    Wendy Lim
    McMaster University and Hamilton General Hospital, Hamilton, Ontario, Canada
    Ann Intern Med 144:673-84. 2006
  6. doi request reprint The diagnosis of myocardial infarction in critically ill patients: an agreement study
    Wendy Lim
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 24:447-52. 2009
  7. pmc Detecting myocardial infarction in critical illness using screening troponin measurements and ECG recordings
    Wendy Lim
    Department of Medicine, McMaster University, Canada
    Crit Care 12:R36. 2008
  8. pmc Elevated troponin and myocardial infarction in the intensive care unit: a prospective study
    Wendy Lim
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care 9:R636-44. 2005
  9. doi request reprint Low-molecular-weight heparin in patients with chronic renal insufficiency
    Wendy Lim
    Department of Medicine, Division of Hematology Thromboembolism, McMaster University, St Joseph s Hospital, Hamilton, ON, Canada
    Intern Emerg Med 3:319-23. 2008
  10. doi request reprint Etiology of troponin elevation in critically ill patients
    Wendy Lim
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 25:322-8. 2010

Detail Information

Publications43

  1. ncbi request reprint Meta-analysis: anticoagulant prophylaxis to prevent symptomatic venous thromboembolism in hospitalized medical patients
    Francesco Dentali
    McMaster University and St Joseph s Healthcare, Hamilton, Ontario, Canada
    Ann Intern Med 146:278-88. 2007
    ..Underutilization of anticoagulant prophylaxis may be due to lack of evidence that prophylaxis prevents clinically important outcomes in hospitalized medical patients at risk for venous thromboembolism...
  2. ncbi request reprint Antiphospholipid antibiodies: a critical review of the literature
    Wendy Lim
    St Joseph s Hospital, Hamilton, Ontario, Canada
    Curr Opin Hematol 14:494-9. 2007
    ..Antithrombotic therapies are the mainstay of treatment to reduce the risk of recurrent thromboembolism that characterizes this condition...
  3. doi request reprint Using low molecular weight heparin in special patient populations
    Wendy Lim
    Department of Medicine, Division of Hematology Thromboembolism, McMaster University, St Joseph s Hospital, 50 Charlton Avenue East, Hamilton, ON, L8N 4A6, Canada
    J Thromb Thrombolysis 29:233-40. 2010
    ..This review summarizes the existing data in these special populations and proposes general recommendations for practice...
  4. doi request reprint Complement and the antiphospholipid syndrome
    Wendy Lim
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Curr Opin Hematol 18:361-5. 2011
    ..Experimental data supporting activation of the complement cascade has provided critical insight into the underlying pathophysiology of aPL-induced pregnancy loss and thrombosis...
  5. ncbi request reprint Meta-analysis: low-molecular-weight heparin and bleeding in patients with severe renal insufficiency
    Wendy Lim
    McMaster University and Hamilton General Hospital, Hamilton, Ontario, Canada
    Ann Intern Med 144:673-84. 2006
    ....
  6. doi request reprint The diagnosis of myocardial infarction in critically ill patients: an agreement study
    Wendy Lim
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 24:447-52. 2009
    ..The aim of the study was to assess agreement among 4 intensivists in diagnosing myocardial infarction (MI) in critically ill patients based on screening electrocardiograms (ECGs) and cardiac troponin (cTn) levels...
  7. pmc Detecting myocardial infarction in critical illness using screening troponin measurements and ECG recordings
    Wendy Lim
    Department of Medicine, McMaster University, Canada
    Crit Care 12:R36. 2008
    ..This is a prospective screening study...
  8. pmc Elevated troponin and myocardial infarction in the intensive care unit: a prospective study
    Wendy Lim
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care 9:R636-44. 2005
    ....
  9. doi request reprint Low-molecular-weight heparin in patients with chronic renal insufficiency
    Wendy Lim
    Department of Medicine, Division of Hematology Thromboembolism, McMaster University, St Joseph s Hospital, Hamilton, ON, Canada
    Intern Emerg Med 3:319-23. 2008
    ..LMWHs with a higher molecular weight may be less prone to accumulation and bleeding. LMWH must be used carefully in patients with renal insufficiency, particularly in those with severe renal impairment...
  10. doi request reprint Etiology of troponin elevation in critically ill patients
    Wendy Lim
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 25:322-8. 2010
    ..The aim of this study was to assess the etiology of cardiac troponin elevation among patients admitted to the intensive care unit (ICU) and to examine whether etiology affects mortality and length of stay...
  11. ncbi request reprint JOE DOUPE LECTURE: Cardiac troponin in the intensive care unit
    Wendy Lim
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin Invest Med 32:E405-10. 2009
    ..The interpretation, clinical significance and appropriate management of an elevated troponin measurement in critically ill patients are uncertain...
  12. ncbi request reprint Reliability of electrocardiogram interpretation in critically ill patients
    Wendy Lim
    Medicine and Clinical Epidemiology, McMaster University, Hamilton, Ontario, Canada
    Crit Care Med 34:1338-43. 2006
    ..To assess the intrarater and interrater reliability of electrocardiogram (ECG) interpretation in critically ill patients and to assess the effect of knowledge of cardiac troponin values on these reliability estimates...
  13. ncbi request reprint Elevated cardiac troponin measurements in critically ill patients
    Wendy Lim
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Arch Intern Med 166:2446-54. 2006
    ..We reviewed the frequency of cTn elevation and its association with mortality and length of ICU stay in these patients...
  14. ncbi request reprint Elevated cardiac troponin levels in critically ill patients: prevalence, incidence, and outcomes
    Wendy Lim
    The Department of Medicine, McMaster University, Hamilton, Ontario, CA
    Am J Crit Care 15:280-8; quiz 289. 2006
    ..Levels of cardiac troponin, a sensitive and specific marker of myocardial injury, are often elevated in critically ill patients...
  15. doi request reprint Low-molecular-weight heparin thromboprophylaxis in medical-surgical critically ill patients: a systematic review
    Christine Ribic
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 24:197-205. 2009
    ..The study aimed to systematically review the effect of low-molecular-weight heparin (LMWH) thromboprophylaxis in medical-surgical critically ill patients in the intensive care unit...
  16. ncbi request reprint Low molecular weight heparin and bleeding in patients with chronic renal failure
    Mark Crowther
    St Joseph s Hospital, Hamilton, Ontario, Canada
    Curr Opin Pulm Med 13:409-13. 2007
    ..Consequently, care should be employed when LMWH is administered to patients with impaired renal function as reduced clearance and bioaccumulation may cause bleeding...
  17. doi request reprint Heparin thromboprophylaxis in medical-surgical critically ill patients: a systematic review and meta-analysis of randomized trials
    Waleed Alhazzani
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care Med 41:2088-98. 2013
    ..The objective of this systematic review was to systematically review the efficacy and safety of heparin thromboprophylaxis in medical-surgical patients in the ICU...
  18. ncbi request reprint Periprocedural heparin bridging in patients receiving vitamin K antagonists: systematic review and meta-analysis of bleeding and thromboembolic rates
    Deborah Siegal
    Department of Medicine, Division of Hematology and Thromboembolism, McMaster University, Hamilton, Ontario, Canada
    Circulation 126:1630-9. 2012
    ..Optimal periprocedural anticoagulation has not been established...
  19. pmc Prevention of VTE in nonsurgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Susan R Kahn
    Department of Medicine, McGill University, Montreal, QC, Canada
    Chest 141:e195S-226S. 2012
    ..This guideline addressed VTE prevention in hospitalized medical patients, outpatients with cancer, the chronically immobilized, long-distance travelers, and those with asymptomatic thrombophilia...
  20. doi request reprint The frequency and clinical significance of thrombocytopenia complicating critical illness: a systematic review
    Phil Hui
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Chest 139:271-8. 2011
    ..The objective of this study was to systematically review the prevalence, incidence, and consequences of, and risk factors for, thrombocytopenia among critically ill patients...
  21. ncbi request reprint Management of antiphospholipid antibody syndrome: a systematic review
    Wendy Lim
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    JAMA 295:1050-7. 2006
    ..Patients with APS may be at increased risk of recurrent arterial or venous thrombosis or pregnancy loss...
  22. ncbi request reprint Combined aspirin-oral anticoagulant therapy compared with oral anticoagulant therapy alone among patients at risk for cardiovascular disease: a meta-analysis of randomized trials
    Francesco Dentali
    Department of Medicine, McMaster University, and St Joseph s Healthcare, Hamilton, Ontario, Canada
    Arch Intern Med 167:117-24. 2007
    ..We performed a systematic review and meta-analysis of randomized controlled trials comparing these 2 treatment strategies (combined aspirin-OAC therapy vs OAC therapy alone) to assess the therapeutic benefits and risks...
  23. doi request reprint Has the incidence of deep vein thrombosis in patients undergoing total hip/knee arthroplasty changed over time? A systematic review of randomized controlled trials
    Katharine He Xing
    Department of Medicine, McMaster University and St Joseph s Healthcare, Hamilton, ON, Canada
    Thromb Res 123:24-34. 2008
    ..There is a perception in the orthopaedic and thromboembolism community that the incidence of deep vein thrombosis (DVT) has decreased in patients undergoing total knee arthroplasty (TKA) or total hip arthroplasty (THA)...
  24. ncbi request reprint Systematic review: efficacy and safety of rituximab for adults with idiopathic thrombocytopenic purpura
    Donald M Arnold
    McMaster University and Juravinski Cancer Centre, Hamilton, Ontario, Canada
    Ann Intern Med 146:25-33. 2007
    ..Rituximab, a monoclonal anti-CD20 antibody, is increasingly used to treat idiopathic thrombocytopenic purpura (ITP)...
  25. pmc Inherited thrombophilia and pregnancy associated venous thromboembolism
    Wendy Lim
    Department of Medicine, McMaster University, St Joseph s Hospital, Canada
    BMJ 334:1318-21. 2007
  26. pmc Measuring the anticoagulant effect of low molecular weight heparins in the critically ill
    Mark Crowther
    St Joseph s Hospital, Hamilton, Ontario, Canada
    Crit Care 10:150. 2006
    ..These findings provide reassurance that subcutaneously administered medications may be used in critically ill patients with edema...
  27. ncbi request reprint Systematic review: D-dimer to predict recurrent disease after stopping anticoagulant therapy for unprovoked venous thromboembolism
    Madeleine Verhovsek
    McMaster University and St Joseph s Hospital, Hamilton, Ontario, Canada
    Ann Intern Med 149:481-90, W94. 2008
    ..Methods for predicting risk for recurrence may identify low-risk patients who are less likely to benefit from prolonged anticoagulation...
  28. doi request reprint Prognostic value of troponin and creatine kinase muscle and brain isoenzyme measurement after noncardiac surgery: a systematic review and meta-analysis
    Michael Levy
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Anesthesiology 114:796-806. 2011
    ..There is uncertainty regarding the prognostic value of troponin and creatine kinase muscle and brain isoenzyme measurements after noncardiac surgery...
  29. ncbi request reprint Safety and efficacy of low molecular weight heparins for hemodialysis in patients with end-stage renal failure: a meta-analysis of randomized trials
    Wendy Lim
    Department of Medicine, McMaster University, St Joseph s Hospital, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada
    J Am Soc Nephrol 15:3192-206. 2004
    ..However, inferences from these trials assessing anticoagulation for patients who undergo hemodialysis will continue to be weak until larger, more rigorous randomized trials are conducted...
  30. ncbi request reprint Low-molecular-weight heparins for the treatment of acute coronary syndrome and venous thromboembolism in patients with chronic renal insufficiency
    Wendy Lim
    Department of Medicine, McMaster University and St Joseph s Hospital, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
    Thromb Res 118:409-16. 2006
    ....
  31. doi request reprint Systematic review and meta-analysis methodology
    Mark Crowther
    Department of Haematology, Worcestershire Royal Hospital, Worcester, United Kingdom
    Blood 116:3140-6. 2010
    ..This article aims to provide the reader with a practical overview of systematic review and meta-analysis methodology, with a focus on the process of performing a review and the related issues at each step...
  32. doi request reprint Myocardial injury after noncardiac surgery: a large, international, prospective cohort study establishing diagnostic criteria, characteristics, predictors, and 30-day outcomes
    Fernando Botto
    From the Hamilton General Hospital, David Braley Cardiac, Vascular, and Stroke Research Institute, Population Health Research Institute, Hamilton, Ontario, Canada P J D and Members of The VISION Writing Group and VISION Investigators, who are listed in appendix 1 and appendix 2, respectively Population Health Research Institute, Hamilton, Ontario, Canada Department of Clinical Research, Estudios Clinicos Latino America ECLA, Rosario, Argentina Biomedical Research Institute Sant Pau IIB Sant Pau, Barcelona, Spain The Chinese University of Hong Kong, Shatin, N T, Hong Kong Universidad Autónoma de Bucaramanga and Fundación Cardioinfantil, Colombia St John s Medical College and Research Institute, Bangalore, India Department of Surgery, University of Manitoba, Winnipeg, Manitoba, Canada Department of Clinical Epidemiology and Biostatistics and Department of Medicine, McMaster University, Hamilton, Ontario, Canada Hospital General Universitario Gregorio Maranon, Madrid, Spain University of Alberta, Edmonton, Alberta, Canada University of Malaya, Kuala Lampur, Malaysia Research Institute Hcor Hospital do Coracao, Sao Paulo, Brazil Barts and The London School of Medicine and Dentistry
    Anesthesiology 120:564-78. 2014
    ..The study's four objectives were to determine the diagnostic criteria, characteristics, predictors, and 30-day outcomes of MINS...
  33. doi request reprint Selective D-dimer testing for diagnosis of a first suspected episode of deep venous thrombosis: a randomized trial
    Lori Ann Linkins
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 158:93-100. 2013
    ..Changing the use of testing and the threshold level for a positive test result on the basis of risk for DVT might improve the tradeoff between sensitivity and specificity and reduce the need for testing...
  34. doi request reprint A rational approach to the diagnosis and management of thrombocytopenia in the hospitalized patient
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Semin Hematol 48:251-8. 2011
    ....
  35. doi request reprint The use and abuse of surrogate endpoints in clinical research in transfusion medicine
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 48:1547-9. 2008
  36. ncbi request reprint Avoiding transfusions in children undergoing cardiac surgery: a meta-analysis of randomized trials of aprotinin
    Donald M Arnold
    Canadian Blood Services, Hamilton, Ontario, Canada
    Anesth Analg 102:731-7. 2006
    ..Further high-quality trials with clinically important outcomes may be warranted before aprotinin can be routinely recommended in this population...
  37. ncbi request reprint A framework for resolving disagreement during end of life care in the critical care unit
    Karen Choong
    Department of Pediatrics and Critical Care, McMaster Children s Hospital, McMaster University, Hamilton, Ontario
    Clin Invest Med 33:E240-53. 2010
    ..Such disagreements can cause tension and moral distress among families and clinicians...
  38. ncbi request reprint Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: a systematic review of randomized trials
    Yoan K Kagoma
    Applied Science and Engineering, University of Toronto, Toronto, Ontario, Canada
    Thromb Res 123:687-96. 2009
    ..To address this issue we performed a systematic review of randomized trials describing the use of tranexamic acid, epsilon aminocaproic acid, or aprotinin administration in the perioperative setting...
  39. doi request reprint A blinded study of bone marrow examinations in patients with primary immune thrombocytopenia
    Vishwanath K Mahabir
    Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada
    Eur J Haematol 90:121-6. 2013
    ..The objectives of this study were to determine the inter-rater reliability of bone marrow examinations and to identify distinguishing morphological features of ITP bone marrows under controlled conditions...
  40. ncbi request reprint CNS prophylaxis and treatment in non-Hodgkin's lymphoma: variation in practice and lessons from the literature
    Rena Buckstein
    Department of Medicine, University of Toronto, Toronto Sunnybrook Regional Cancer Centre, 2075 Bayview Avenue, Toronto, Ont, Canada
    Leuk Lymphoma 44:955-62. 2003
    ..Patients at high risk by International prognostic index criteria are at an increased risk for CNS relapse. A RCT comparing standard chemotherapy with or without CNS prophylaxis in selected patients is needed...
  41. ncbi request reprint Frequency and spectrum of cancers in the Peutz-Jeghers syndrome
    Nicholas Hearle
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, United Kingdom
    Clin Cancer Res 12:3209-15. 2006
    ..Although an increased cancer risk in Peutz-Jeghers syndrome is established, data on the spectrum of tumors associated with the disease and the influence of germ-line STK11/LKB1 (serine/threonine kinase) mutation status are limited...
  42. ncbi request reprint Relative frequency and morphology of cancers in STK11 mutation carriers
    Wendy Lim
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
    Gastroenterology 126:1788-94. 2004
    ..There is limited data on the spectrum and risk for cancer associated with germline serine/threonine protein kinase 11 (STK11) mutations that cause Peutz-Jeghers syndrome (PJS)...
  43. ncbi request reprint [Fondaparinux--evolution or revolution in anticoagulant care?]
    Mark Crowther
    Pol Arch Med Wewn 117:5-7. 2007