Chiu-Yin Kwan

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint Effects of papaya seed extract and benzyl isothiocyanate on vascular contraction
    Ruth K Wilson
    Smooth Muscle Research Program, Department of Medicine, HSC 4N40, McMaster University, 1200 Main Street W, L8N 3Z5, Hamilton, ON, Canada
    Life Sci 71:497-507. 2002
  2. ncbi request reprint The control of vascular smooth muscle function: my life-long learning and continuous discovery with Professor E.E. Daniel
    Chiu Yin Kwan
    Department of Medicine and Smooth Muscle Research Program, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    Can J Physiol Pharmacol 83:669-74. 2005
  3. ncbi request reprint A novel in vitro endothelium-dependent vascular relaxant effect of Apocynum venetum leaf extract
    Chiu Yin Kwan
    Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Clin Exp Pharmacol Physiol 32:789-95. 2005
  4. ncbi request reprint Endothelium-dependent vasorelaxant effects of the aqueous extracts of the Eucommia ulmoides Oliv. leaf and bark: implications on their antihypertensive action
    Chiu Yin Kwan
    HSC 4N40, Department of, Medicine, Faculty of Health Sciences, McMaster University, 1200 Main Street West, Hamilton, ON, Canada L8N 3Z5
    Vascul Pharmacol 40:229-35. 2003
  5. ncbi request reprint Vascular effects of Siberian ginseng (Eleutherococcus senticosus): endothelium-dependent NO- and EDHF-mediated relaxation depending on vessel size
    Chiu Yin Kwan
    HSC 4N40, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, L8 N 3Z5, Canada
    Naunyn Schmiedebergs Arch Pharmacol 369:473-80. 2004
  6. ncbi request reprint Endothelium-dependent vascular relaxation induced by Eucommia ulmoides Oliv. bark extract is mediated by NO and EDHF in small vessels
    Chiu Yin Kwan
    HSC 4N40, Department of Medicine, Faculty of Health Sciences, McMaster University, 1200 Main Street West, L8N 3Z5, Hamilton, Ontario, Canada
    Naunyn Schmiedebergs Arch Pharmacol 369:206-11. 2004
  7. ncbi request reprint In vitro vasodilator mechanisms of the indole alkaloids rhynchophylline and isorhynchophylline, isolated from the hook of Uncaria rhynchophylla (Miquel)
    Wen Bo Zhang
    Department of Medicine, Faculty of Health Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada
    Naunyn Schmiedebergs Arch Pharmacol 369:232-8. 2004
  8. ncbi request reprint In vitro relaxation of vascular smooth muscle by atropine: involvement of K+ channels and endothelium
    Chiu Yin Kwan
    Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Naunyn Schmiedebergs Arch Pharmacol 368:1-9. 2003
  9. ncbi request reprint The epoxy group of pramanicin is required for the optimal endothelium-dependent relaxation of rat aorta
    Chiu Yin Kwan
    Department of Medicine, Faculty of Health Sciences, McMaster University, Ontario, Canada
    J Pharmacol Sci 92:203-8. 2003
  10. ncbi request reprint Pramanicin, an antifungal agent, raises cytosolic Ca2+ and causes cell death in vascular endothelial cells
    Chiu Yin Kwan
    Department of Medicine, HSC 4N40, Faculty of Health Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Vascul Pharmacol 40:35-42. 2003

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Effects of papaya seed extract and benzyl isothiocyanate on vascular contraction
    Ruth K Wilson
    Smooth Muscle Research Program, Department of Medicine, HSC 4N40, McMaster University, 1200 Main Street W, L8N 3Z5, Hamilton, ON, Canada
    Life Sci 71:497-507. 2002
    ....
  2. ncbi request reprint The control of vascular smooth muscle function: my life-long learning and continuous discovery with Professor E.E. Daniel
    Chiu Yin Kwan
    Department of Medicine and Smooth Muscle Research Program, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    Can J Physiol Pharmacol 83:669-74. 2005
    ....
  3. ncbi request reprint A novel in vitro endothelium-dependent vascular relaxant effect of Apocynum venetum leaf extract
    Chiu Yin Kwan
    Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Clin Exp Pharmacol Physiol 32:789-95. 2005
    ..5. These results provide a strong scientific basis for the folk use of AVLE decoction for antihypertensive therapy in traditional Chinese medicine...
  4. ncbi request reprint Endothelium-dependent vasorelaxant effects of the aqueous extracts of the Eucommia ulmoides Oliv. leaf and bark: implications on their antihypertensive action
    Chiu Yin Kwan
    HSC 4N40, Department of, Medicine, Faculty of Health Sciences, McMaster University, 1200 Main Street West, Hamilton, ON, Canada L8N 3Z5
    Vascul Pharmacol 40:229-35. 2003
    ..Results in this study have provided the first evidence on the in vitro vasorelaxant action of E. ulmoides Oliv. that forms the pharmacological basis for its well-documented antihypertensive action...
  5. ncbi request reprint Vascular effects of Siberian ginseng (Eleutherococcus senticosus): endothelium-dependent NO- and EDHF-mediated relaxation depending on vessel size
    Chiu Yin Kwan
    HSC 4N40, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, L8 N 3Z5, Canada
    Naunyn Schmiedebergs Arch Pharmacol 369:473-80. 2004
    ..Other vasorelaxation pathways, such as inhibition of K(+)-channels and activation of muscarinic receptors, may also be involved...
  6. ncbi request reprint Endothelium-dependent vascular relaxation induced by Eucommia ulmoides Oliv. bark extract is mediated by NO and EDHF in small vessels
    Chiu Yin Kwan
    HSC 4N40, Department of Medicine, Faculty of Health Sciences, McMaster University, 1200 Main Street West, L8N 3Z5, Hamilton, Ontario, Canada
    Naunyn Schmiedebergs Arch Pharmacol 369:206-11. 2004
    ..Results of our study offer a plausible mechanistic basis for the vasorelaxing action of Eucommia ulmoides Oliv., which may account for its well-documented antihypertensive action...
  7. ncbi request reprint In vitro vasodilator mechanisms of the indole alkaloids rhynchophylline and isorhynchophylline, isolated from the hook of Uncaria rhynchophylla (Miquel)
    Wen Bo Zhang
    Department of Medicine, Faculty of Health Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada
    Naunyn Schmiedebergs Arch Pharmacol 369:232-8. 2004
    ..While there is no discrimination between the two isomers with respect to the contraction induced by KCl or agonists (PE and U46619), differential effects between Rhy and Isorhy were seen on caffeine- and CPA-induced contractions...
  8. ncbi request reprint In vitro relaxation of vascular smooth muscle by atropine: involvement of K+ channels and endothelium
    Chiu Yin Kwan
    Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Naunyn Schmiedebergs Arch Pharmacol 368:1-9. 2003
    ....
  9. ncbi request reprint The epoxy group of pramanicin is required for the optimal endothelium-dependent relaxation of rat aorta
    Chiu Yin Kwan
    Department of Medicine, Faculty of Health Sciences, McMaster University, Ontario, Canada
    J Pharmacol Sci 92:203-8. 2003
    ..The potent, selective, and irreversible inhibitory effect of PMC on the endothelial function points to its potential development into an anti-angiogenic drug...
  10. ncbi request reprint Pramanicin, an antifungal agent, raises cytosolic Ca2+ and causes cell death in vascular endothelial cells
    Chiu Yin Kwan
    Department of Medicine, HSC 4N40, Faculty of Health Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Vascul Pharmacol 40:35-42. 2003
    ....
  11. ncbi request reprint Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: cardiovascular effects and mechanisms of action
    Chiu Yin Kwan
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Acta Pharmacol Sin 23:1057-68. 2002
    ..TET is also known for its anti-inflammatory and anti-fibrogenic actions, which make TET and related compound potentially useful in the treatment of lung silicosis, liver cirrhosis, and rheumatoid arthritis...
  12. pmc Ca2+-mediated ascorbate release from coronary artery endothelial cells
    Kim A Davis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Br J Pharmacol 147:131-9. 2006
    ..5.--PCEC but not pig coronary artery smooth muscle cells show a Ca(2+)- mediated Asc release pathway that may be activated by agents such as ATP...
  13. ncbi request reprint Traditional herbal medicine research with special reference to tetrandrine and related bis-benzylisoquinoline alkaloids: a preface to this special issue on herbal drugs
    Chiu Yin Kwan
    Department of Medicine, Faculty of Health Siences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Acta Pharmacol Sin 23:I. 2002
  14. ncbi request reprint Peroxynitrite resistance of sarco/endoplasmic reticulum Ca2+ pump in pig coronary artery endothelium and smooth muscle
    Tracey Schmidt
    Department of Medicine, McMaster University, Hamilton, Ont, Canada L8N3Z5
    Cell Calcium 36:77-82. 2004
    ..The greater resistance of endothelium to peroxynitrite may play a protective role in pathological conditions such as ischemia-reperfusion when excess free radicals are produced...
  15. ncbi request reprint Effects of peroxynitrite on sarco/endoplasmic reticulum Ca2+ pump isoforms SERCA2b and SERCA3a
    Ashok K Grover
    Dept of Medicine, HSC 4N41, McMaster Univ, 1200 Main St West, Hamilton, Ontario L8N 3Z5 Canada
    Am J Physiol Cell Physiol 285:C1537-43. 2003
    ..We conclude that the resistance of SERCA3a to peroxynitrite may aid the cells expressing them in functioning during exposure to oxidative stress...
  16. ncbi request reprint Tetrandrine potentiates caffeine-induced contraction but inhibits phenylephrine-induced contraction in perfused rat mesenteric artery
    Chiu Yin Kwan
    Department of Medicine, Faculty of Health Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5 Canada
    Naunyn Schmiedebergs Arch Pharmacol 366:613-9. 2002
    ..The augmentation of caffeine-induced responses by TET, particularly in Ca(2+)-free medium, is likely to be due to its partial inhibition of the sarcoplasmic reticulum Ca(2+)-ATPase pump...
  17. ncbi request reprint Learning of medical pharmacology via innovation: a personal experience at McMaster and in Asia
    Chiu Yin Kwan
    Department of Medicine, HSC 4N40, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada
    Acta Pharmacol Sin 25:1186-94. 2004
    ..Evidence is presented that this is indeed happening...
  18. ncbi request reprint Problem-based learning and teaching of medical pharmacology
    Chiu Yin Kwan
    Department of Medicine, Faculty of Health Science, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Naunyn Schmiedebergs Arch Pharmacol 366:10-7. 2002
    ..This is most effectively achieved in a student-centered environment conducive to life-long learning...
  19. ncbi request reprint Characterization of a novel tetrandrine-induced contraction in rat tail artery
    Francis Ifejika Achike
    Clinical Sciences Section, International Medical University, Kuala Lumpur, Malaysia
    Acta Pharmacol Sin 23:698-704. 2002
    ..The characteristics of this contraction were studied...
  20. ncbi request reprint A new view of K+ -induced contraction in rat aorta: the role of Ca2+ binding
    Gennadi M Kravtsov
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong, ROC
    Pflugers Arch 446:529-40. 2003
    ..This Ca2+ binding may then activate actin-myosin interaction...
  21. ncbi request reprint Green tea catechins evoke a phasic contraction in rat aorta via H2O2-mediated multiple-signalling pathways
    Jian Zhong Shen
    Department of Pharmacology, School of Medicine, Zhejiang University, Hubin Campus, Hangzhou, People s Republic of China
    Clin Exp Pharmacol Physiol 30:88-95. 2003
    ....
  22. ncbi request reprint Exploratory thoughts concerning educational reform with problem-based learning in China
    Guangtai Song
    Department of Pedodontics, School of Stomatology, Key Laboratory for Oral Biomedical Engineering, Ministry of Education KLOMB, Wuhan University, Wuhan, PR China
    Teach Learn Med 17:382-4. 2005
    ..He describes his observations and thoughts as they relate to the current reform of health sciences education in China...
  23. ncbi request reprint Nitric oxide, human diseases and the herbal products that affect the nitric oxide signalling pathway
    Francis I Achike
    Clinical Sciences Section, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia
    Clin Exp Pharmacol Physiol 30:605-15. 2003
    ..Many plant extracts or purified drugs derived from Chinese medicinal herbs with proposed actions on NO pathways are also reviewed...
  24. ncbi request reprint Dental education in Wuhan, China: challenges and changes
    Cui Huang
    Department of Prosthodontics, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, People s Republic of China 430079
    J Dent Educ 71:304-11. 2007
    ..The curriculum modifications that have been achieved to date as well as the existing challenges are discussed to provide the reader with an understanding of contemporary dental education in China...
  25. ncbi request reprint Dual vascular effects of leptin via endothelium: hypothesis and perspective
    Yuk Man Leung
    Department of Physiology, China Medical University, Taichung 404, Taiwan, Republic of China
    Chin J Physiol 51:1-6. 2008
    ..How these dual effects of leptin on EC might be related to EC ionic channels is also discussed...