Clive Kearon

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. doi request reprint Long-term anticoagulation for venous thromboembolism: duration of treatment and management of warfarin therapy
    Clive Kearon
    McMaster University, Hamilton, ON, Canada
    Clin Chest Med 31:719-30. 2010
  2. ncbi request reprint Laboratory monitoring of low-molecular-weight heparin therapy
    C Kearon
    McMaster University and Henderson Research Center, Hamilton, ON, Canada
    J Thromb Haemost 2:1006-7. 2004
  3. pmc Influence of preceding length of anticoagulant treatment and initial presentation of venous thromboembolism on risk of recurrence after stopping treatment: analysis of individual participants' data from seven trials
    Florent Boutitie
    Hospices Civils de Lyon, Service de Biostatistique, UMR, CHU de Lyon, France
    BMJ 342:d3036. 2011
  4. doi request reprint Risk of recurrent venous thromboembolism after stopping treatment in cohort studies: recommendation for acceptable rates and standardized reporting
    C Kearon
    Department Internal Medicine, McMaster University, Hamilton, ON, Canada
    J Thromb Haemost 8:2313-5. 2010
  5. doi request reprint Influence of hereditary or acquired thrombophilias on the treatment of venous thromboembolism
    Clive Kearon
    McMaster University, Hamilton, Ontario, Canada
    Curr Opin Hematol 19:363-70. 2012
  6. doi request reprint A conceptual framework for two phases of anticoagulant treatment of venous thromboembolism
    C Kearon
    McMaster University, Hamilton, Ontario, Canada
    J Thromb Haemost 10:507-11. 2012
  7. ncbi request reprint Duration of venous thromboembolism prophylaxis after surgery
    Clive Kearon
    McMaster Clinic, 70 Wing, Henderson General Hospital, 711 Concession Street, Hamilton, Ontario, L8V 1C3 Canada
    Chest 124:386S-392S. 2003
  8. doi request reprint Influence of thrombophilia on risk of recurrent venous thromboembolism while on warfarin: results from a randomized trial
    Clive Kearon
    McMaster University, Hamilton, ON
    Blood 112:4432-6. 2008
  9. pmc Stopping anticoagulant therapy after an unprovoked venous thromboembolism
    Clive Kearon
    Hamilton Health Sciences, Henderson Division, Hamilton, Ont
    CMAJ 179:401-2. 2008
  10. ncbi request reprint Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Clive Kearon
    Hamilton Health Sciences, Henderson Division, 711 Concession Street, Hamilton, Ontario, Canada
    Chest 133:454S-545S. 2008

Detail Information

Publications89

  1. doi request reprint Long-term anticoagulation for venous thromboembolism: duration of treatment and management of warfarin therapy
    Clive Kearon
    McMaster University, Hamilton, ON, Canada
    Clin Chest Med 31:719-30. 2010
    ..A systematic approach to managing warfarin therapy improves its efficacy, safety, and acceptability...
  2. ncbi request reprint Laboratory monitoring of low-molecular-weight heparin therapy
    C Kearon
    McMaster University and Henderson Research Center, Hamilton, ON, Canada
    J Thromb Haemost 2:1006-7. 2004
  3. pmc Influence of preceding length of anticoagulant treatment and initial presentation of venous thromboembolism on risk of recurrence after stopping treatment: analysis of individual participants' data from seven trials
    Florent Boutitie
    Hospices Civils de Lyon, Service de Biostatistique, UMR, CHU de Lyon, France
    BMJ 342:d3036. 2011
    ....
  4. doi request reprint Risk of recurrent venous thromboembolism after stopping treatment in cohort studies: recommendation for acceptable rates and standardized reporting
    C Kearon
    Department Internal Medicine, McMaster University, Hamilton, ON, Canada
    J Thromb Haemost 8:2313-5. 2010
  5. doi request reprint Influence of hereditary or acquired thrombophilias on the treatment of venous thromboembolism
    Clive Kearon
    McMaster University, Hamilton, Ontario, Canada
    Curr Opin Hematol 19:363-70. 2012
    ..Antiphospholipid antibodies are considered acquired thrombophilic states. Testing for these abnormalities is widespread. This review will consider if the results of testing should influence how patients with VTE are treated...
  6. doi request reprint A conceptual framework for two phases of anticoagulant treatment of venous thromboembolism
    C Kearon
    McMaster University, Hamilton, Ontario, Canada
    J Thromb Haemost 10:507-11. 2012
    ....
  7. ncbi request reprint Duration of venous thromboembolism prophylaxis after surgery
    Clive Kearon
    McMaster Clinic, 70 Wing, Henderson General Hospital, 711 Concession Street, Hamilton, Ontario, L8V 1C3 Canada
    Chest 124:386S-392S. 2003
    ..If anticoagulant drug therapy is stopped after 7 to 10 days, an additional month of prophylaxis with aspirin should be considered...
  8. doi request reprint Influence of thrombophilia on risk of recurrent venous thromboembolism while on warfarin: results from a randomized trial
    Clive Kearon
    McMaster University, Hamilton, ON
    Blood 112:4432-6. 2008
    ..7; 95% CI, 0.2-2.3) or more than one (HR, 0.7; 95% CI, 0.2-3.4) defect. We conclude that single or multiple thrombophilic defects are not associated with a higher risk of recurrent VTE during warfarin therapy...
  9. pmc Stopping anticoagulant therapy after an unprovoked venous thromboembolism
    Clive Kearon
    Hamilton Health Sciences, Henderson Division, Hamilton, Ont
    CMAJ 179:401-2. 2008
  10. ncbi request reprint Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Clive Kearon
    Hamilton Health Sciences, Henderson Division, 711 Concession Street, Hamilton, Ontario, Canada
    Chest 133:454S-545S. 2008
    ..For extensive superficial vein thrombosis, we recommend treatment with prophylactic or intermediate doses of LMWH or intermediate doses of UFH for 4 weeks (Grade 1B)...
  11. ncbi request reprint Comparison of 1 month with 3 months of anticoagulation for a first episode of venous thromboembolism associated with a transient risk factor
    C Kearon
    McMaster University, Hamilton, Ontario, Canada
    J Thromb Haemost 2:743-9. 2004
    ..Retrospective analyses suggest that 1 month of anticoagulation is adequate for patients whose venous thromboembolic event was provoked by a transient risk factor...
  12. ncbi request reprint Management of anticoagulation in patients who require invasive procedures
    Clive Kearon
    Department of Medicine, McMaster University and Henderson Research Centre, Hamilton, Ontario, Canada
    Semin Vasc Med 3:285-94. 2003
    ....
  13. ncbi request reprint Indefinite anticoagulation after a first episode of unprovoked venous thromboembolism: yes
    C Kearon
    McMaster University and Henderson Research Centre, Hamilton Health Sciences Henderson Division, 711 Concession Street, Hamilton, Ontario, Canada
    J Thromb Haemost 5:2330-5. 2007
  14. ncbi request reprint Subcutaneous unfractionated heparin for the treatment of venous thromboembolism
    Clive Kearon
    McMaster University and the Henderson Research Centre, Hamilton, ON, Canada
    Curr Opin Pulm Med 13:398-402. 2007
    ..These two requirements are a barrier to treatment of venous thromboembolism with unfractionated heparin, and it is uncertain if they are necessary...
  15. ncbi request reprint Long-term management of patients after venous thromboembolism
    Clive Kearon
    Department of Medicine, McMaster University, McMaster Clinic, Henderson General Hospital, Hamilton, Ontario, Canada
    Circulation 110:I10-8. 2004
    ..Oral direct thrombin inhibitors also appear suitable for long-term prevention of recurrent VTE but await regulatory approval and comparison with VK antagonists...
  16. ncbi request reprint An evaluation of D-dimer in the diagnosis of pulmonary embolism: a randomized trial
    Clive Kearon
    McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada
    Ann Intern Med 144:812-21. 2006
    ..It may be safe to omit additional diagnostic testing in selected patients with suspected pulmonary embolism (PE) who have a negative D-dimer test, but this approach has never been evaluated in a randomized, controlled trial...
  17. ncbi request reprint Dose-response study of recombinant human soluble thrombomodulin (ART-123) in the prevention of venous thromboembolism after total hip replacement
    C Kearon
    Henderson Research Center, McMaster University, Hamilton, Ontario, Canada
    J Thromb Haemost 3:962-8. 2005
    ..This study was performed to identify an effective and safe dose of ART-123 for prevention of venous thromboembolism after elective, unilateral total hip replacement...
  18. ncbi request reprint Natural history of venous thromboembolism
    Clive Kearon
    McMaster Clinic, Henderson General Hospital, Hamilton, Ontario, Canada
    Circulation 107:I22-30. 2003
    ....
  19. doi request reprint Balancing risks and benefits of extended anticoagulant therapy for idiopathic venous thrombosis
    C Kearon
    Hamilton Health Sciences, Henderson Division, Hamilton, Ontario, Canada
    J Thromb Haemost 7:296-300. 2009
    ..Although a number of factors are associated with a reduced risk of recurrence, they require further validation before it is appropriate to routinely stop anticoagulants after 3 months in patients with idiopathic proximal DVT or PE...
  20. ncbi request reprint Duration of anticoagulation for venous thromboembolism
    C Kearon
    McMaster University, Hamilton, Ontario, Canada
    J Thromb Thrombolysis 12:59-65. 2001
    ....
  21. ncbi request reprint Graduated compression stockings to prevent venous thromboembolism in hospital: evidence from patients with acute stroke
    Clive Kearon
    Department of Medicine, McMaster University, Ontario, Canada
    Pol Arch Med Wewn 121:40-3. 2011
    ..CLOTS 1 and CLOTS 2 question whether graduated compression stockings prevent VTE and suggest the need for further trials evaluating their efficacy in medical and surgical patients...
  22. doi request reprint Extended anticoagulation for unprovoked venous thromboembolism: a majority of patients should be treated
    Clive Kearon
    McMaster University, Hamilton, ON, Canada
    J Thromb Thrombolysis 31:295-300. 2011
    ....
  23. pmc Excluding pulmonary embolism with helical (spiral) computed tomography: Evidence is catching up with enthusiasm
    Clive Kearon
    Clinical Thrombosis Service, Henderson General Hospital, Hamilton, Ont
    CMAJ 168:1430-1. 2003
  24. ncbi request reprint Comparison of low-intensity warfarin therapy with conventional-intensity warfarin therapy for long-term prevention of recurrent venous thromboembolism
    Clive Kearon
    McMaster University, Hamilton, Ont
    N Engl J Med 349:631-9. 2003
    ..After three months of conventional warfarin therapy, a lower dose of anticoagulant medication may result in less bleeding and still prevent recurrent venous thromboembolism...
  25. pmc Diagnosis of DVT: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Shannon M Bates
    Department of Medicine, McMaster University and Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada
    Chest 141:e351S-418S. 2012
    ..This guideline focuses on the identification of optimal strategies for the diagnosis of DVT in ambulatory adults...
  26. ncbi request reprint Comparison of fixed-dose weight-adjusted unfractionated heparin and low-molecular-weight heparin for acute treatment of venous thromboembolism
    Clive Kearon
    McMaster University and the Henderson Research Centre, Hamilton, Ontario
    JAMA 296:935-42. 2006
    ..However, subcutaneous administration of fixed-dose, weight-adjusted, unfractionated heparin may be suitable for inpatient and outpatient treatment of venous thromboembolism...
  27. doi request reprint Oral vitamin K effectively treats international normalised ratio (INR) values in excess of 10. Results of a prospective cohort study
    Mark A Crowther
    Division of Hematology and Thromboembolism, McMaster University Faculty of Health Sciences, St Joseph s Hospital, 50 Charlton Ave East, Hamilton, Ontario, Canada
    Thromb Haemost 104:118-21. 2010
    ..Based on our low rate of observed major bleeding we conclude that 2.5 mg of oral vitamin K is a reasonable treatment for patients with INR values of more than 10 who are not actively bleeding...
  28. ncbi request reprint A comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphospholipid antibody syndrome
    Mark A Crowther
    Department of Medicine, McMaster University, Hamilton, Ont, Canada
    N Engl J Med 349:1133-8. 2003
    ..0. However, there are no prospective data to support this approach to thromboprophylaxis...
  29. doi request reprint Treatment of acute venous thromboembolism with dabigatran or warfarin and pooled analysis
    Sam Schulman
    Department of Medicine, McMaster University and Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada S Schulman, C K Department of Hematology, Karolinska University Hospital, Stockholm, Sweden S S Thrombosis Research Institute and University College London, London, UK A K K Brigham and Women s Hospital, Harvard Medical School, Boston, MA S Z G Medical Division 2, Municipal Hospital Friedrichstadt, Dresden, Germany S Schellong Department of Medicine, Sahlgrenska University Hospital Ostra, Gothenburg, Sweden H E Department of Vascular Pathology, Bellevue Hospital, Saint Etienne, France P M Clinical Research, Boehringer Ingelheim, Copenhagen, Denmark A V C Boehringer Ingelheim, Ridgefield, CT J F Boehringer Ingelheim, Reims, France F L M and Boehringer Ingelheim, Biberach and der Riss, BDM, Germany N P
    Circulation 129:764-72. 2014
    ..Dabigatran and warfarin have been compared for the treatment of acute venous thromboembolism (VTE) in a previous trial. We undertook this study to extend those findings...
  30. doi request reprint Extended use of dabigatran, warfarin, or placebo in venous thromboembolism
    Sam Schulman
    Department of Medicine, McMaster University and Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada
    N Engl J Med 368:709-18. 2013
    ..Dabigatran, which is administered in a fixed dose and does not require laboratory monitoring, may be suitable for extended treatment of venous thromboembolism...
  31. pmc Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Clive Kearon
    Departments of Medicine and Clinical Epidemiology and Biostatistics, Michael de Groote School of Medicine, McMaster University, Hamilton, ON, Canada
    Chest 141:e419S-94S. 2012
    ..This article addresses the treatment of VTE disease...
  32. ncbi request reprint Hemorrhagic complications of anticoagulant and thrombolytic treatment: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Sam Schulman
    McMaster Clinics, HHS General Hospital, 237 Barton Street E, Hamilton, Ontario, Canada
    Chest 133:257S-298S. 2008
    ..Thrombolytic therapy increases the risk of major bleeding 1.5-fold to threefold in patients with acute venous thromboembolism, ischemic stroke, or ST-elevation myocardial infarction...
  33. ncbi request reprint Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial
    Mark A Crowther
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 150:293-300. 2009
    ..Low-dose oral vitamin K decreases the international normalized ratio (INR) in overanticoagulated patients who receive warfarin therapy. Its effects on bleeding events are uncertain...
  34. ncbi request reprint Low-dose warfarin in rehabilitating stroke survivors
    Jeffrey S Ginsberg
    Department of Medicine, McMaster University Medical Centre, 1200 Main Street West Rm 3X28, Hamilton, Ontario L8N 3Z5, Canada
    Thromb Res 107:287-90. 2002
    ..0-3.0 is effective for the prevention of VTE. However, because stroke is a major risk factor for bleeding with warfarin, a less intense regimen (target INR < 2.0), might safely prevent VTE in stroke rehabilitation patients...
  35. doi request reprint Perioperative management of oral anticoagulation
    Martin O'Donnell
    McMaster University and Henderson Research Centre, 711 Concession Street, Hamilton, ON L8V 1C3, Canada
    Cardiol Clin 26:299-309, viii. 2008
    ..Good communication between all of these parties is essential to ensure that an optimal management strategy is identified and executed...
  36. ncbi request reprint A randomized trial of diagnostic strategies after normal proximal vein ultrasonography for suspected deep venous thrombosis: D-dimer testing compared with repeated ultrasonography
    Clive Kearon
    McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada
    Ann Intern Med 142:490-6. 2005
    ..With suspected deep venous thrombosis and normal results on proximal vein ultrasonography, a negative d-dimer result may exclude thrombosis and a positive D-dimer result may be an indication for venography...
  37. doi request reprint The effect of prothrombotic blood abnormalities on risk of deep vein thrombosis in users of hormone replacement therapy: a prospective case-control study
    Jim D Douketis
    Department of Medicine, McMaster University, Hamilton, Canada
    Clin Appl Thromb Hemost 17:E106-13. 2011
    ..Few studies have assessed the effect of prothrombotic blood abnormalities on the risk of deep vein thrombosis (DVT) with hormone replacement therapy (HRT)...
  38. ncbi request reprint Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis
    Philip S Wells
    Department of Medicine, Ottawa Hospital, University of Ottawa, Ottawa, Ont, Canada
    N Engl J Med 349:1227-35. 2003
    ....
  39. ncbi request reprint Influence of warfarin on symptoms of fatigue: findings of a randomized trial
    Michael J Kovacs
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Ann Pharmacother 39:840-2. 2005
    ..Some patients develop fatigue while taking warfarin, but causality is uncertain...
  40. ncbi request reprint Low molecular weight heparin administered once versus twice daily in patients with venous thromboembolism: a meta-analysis
    F Couturaud
    Hamilton Civic Hospitals Research Centre and McMaster University, Ontario, Canada
    Thromb Haemost 86:980-4. 2001
    ..However, there is inadequate data from studies that directly compared once-daily and twice-daily administration to be able to exclude the possibility of a higher frequency of fatal bleeding with once-daily therapy...
  41. doi request reprint Dabigatran versus warfarin in the treatment of acute venous thromboembolism
    Sam Schulman
    Department of Medicine, McMaster University and Henderson Research Centre, Hamilton, ON, Canada
    N Engl J Med 361:2342-52. 2009
    ..The direct oral thrombin inhibitor dabigatran has a predictable anticoagulant effect and may be an alternative therapy to warfarin for patients who have acute venous thromboembolism...
  42. ncbi request reprint Perioperative management of oral anticoagulation
    Martin O'Donnell
    McMaster University and Henderson Research Centre, Hamilton, ON L8V 1C3, Canada
    Clin Geriatr Med 22:199-213, xi. 2006
    ..Preceding this is a brief description of the therapies most commonly used in the perioperative period. The prevention of arterial thromboembolism is considered separately from the prevention of venous thrombosis...
  43. doi request reprint Selective D-dimer testing for diagnosis of a first suspected episode of deep venous thrombosis: a randomized trial
    Lori Ann Linkins
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 158:93-100. 2013
    ..Changing the use of testing and the threshold level for a positive test result on the basis of risk for DVT might improve the tradeoff between sensitivity and specificity and reduce the need for testing...
  44. ncbi request reprint Duration of anticoagulant therapy for deep vein thrombosis and pulmonary embolism
    Clive Kearon
    Department of Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, ON, Canada and
    Blood 123:1794-801. 2014
    ....
  45. ncbi request reprint Reduction of out-of-hospital symptomatic venous thromboembolism by extended thromboprophylaxis with low-molecular-weight heparin following elective hip arthroplasty: a systematic review
    Martin O'Donnell
    Henderson Research Centre, Hamilton, Ontario, Canada
    Arch Intern Med 163:1362-6. 2003
    ....
  46. ncbi request reprint Thromboembolism prevention in ischaemic stroke
    Martin O'Donnell
    McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada L8V 1C3
    Lancet 369:1413-5. 2007
  47. ncbi request reprint Duration of therapy for acute venous thromboembolism
    Clive Kearon
    McMaster Clinic, Henderson General Hospital, Hamilton Health Sciences, 711 Concession Street, Hamilton, Ontario L8V 1C3, Canada
    Clin Chest Med 24:63-72. 2003
    ..The data obtained will clarify the role of extended-duration LMWH therapy in patients with and without cancer and may result in the development of novel antithrombotic agents that overcome the limitations of current therapies...
  48. ncbi request reprint A diagnostic strategy involving a quantitative latex D-dimer assay reliably excludes deep venous thrombosis
    Shannon M Bates
    McMaster University Medical Centre, HSC 3W11, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Ann Intern Med 138:787-94. 2003
    ..Because clinical diagnosis is inaccurate, objective testing is usually considered necessary when patients present with suspected deep venous thrombosis (DVT)...
  49. ncbi request reprint Brief communication: Preoperative anticoagulant activity after bridging low-molecular-weight heparin for temporary interruption of warfarin
    MARTIN J O'DONNELL
    McMaster University and Hamilton Health Sciences Foundation, Hamilton, Ontario, Canada
    Ann Intern Med 146:184-7. 2007
    ..Preoperative low-molecular-weight heparin (LMWH) is often used when warfarin therapy is interrupted for surgery...
  50. doi request reprint Evaluation of a venous-return assist device to treat severe post-thrombotic syndrome (VENOPTS). A randomized controlled trial
    MARTIN J O'DONNELL
    Henderson Research Centre, McMaster University, Hamilton, Ontario, Canada
    Thromb Haemost 99:623-9. 2008
    ..2; SD 6.3) compared to control (15.0; SD 6.1). In conclusion, Venowave appears to be a very promising new therapy for patients with severe PTS, which may be used alone or in combination with graduated compression stockings...
  51. ncbi request reprint Early postoperative anticoagulation after mechanical valve replacement: a Canadian survey
    Alexander Kulik
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Heart Valve Dis 15:581-7. 2006
    ..The study aim was to examine the practice patterns of Canadian cardiac surgeons with regard to early postoperative anticoagulation after mechanical valve implantation...
  52. ncbi request reprint Preadmission antithrombotic treatment and stroke severity in patients with atrial fibrillation and acute ischaemic stroke: an observational study
    Martin O'Donnell
    McMaster University, Hamilton, ON, Canada
    Lancet Neurol 5:749-54. 2006
    ....
  53. doi request reprint Accuracy and safety of (99m)Tc-labeled anti-D-dimer (DI-80B3) Fab' fragments (ThromboView®) in the diagnosis of deep vein thrombosis: a phase II study
    James D Douketis
    Dept of Medicine, McMaster University, Hamilton, ON, Canada
    Thromb Res 130:381-9. 2012
    ..This test has an anatomic component to locate DVT and a functional component to differentiate acute (newly formed) thrombus from inactive (old) thrombus...
  54. doi request reprint Dabigatran versus warfarin in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 361:1139-51. 2009
    ..Warfarin reduces the risk of stroke in patients with atrial fibrillation but increases the risk of hemorrhage and is difficult to use. Dabigatran is a new oral direct thrombin inhibitor...
  55. doi request reprint Targeted gene sequencing identifies variants in the protein C and endothelial protein C receptor genes in patients with unprovoked venous thromboembolism
    Cynthia Wu
    From the Department of Clinical Hematology, University of Alberta, Edmonton, Alberta, Canada C W Departments of Medicine D J D, J I W, C K, P C L, Department of Medical Sciences L P, Z L, Department of Pathology and Molecular Medicine J W, and Oncology J J, Thrombosis and Atherosclerosis Research Institute D J D, L P, Z L, J I W, P C L, McMaster University, Hamilton, Ontario, Canada and Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan K D, D G
    Arterioscler Thromb Vasc Biol 33:2674-81. 2013
    ....
  56. ncbi request reprint Interobserver agreement on ultrasound measurements of residual vein diameter, thrombus echogenicity and Doppler venous flow in patients with previous venous thrombosis
    Lori Ann Linkins
    McMaster University, Hamilton, Ontario, Canada
    Thromb Res 117:241-7. 2006
    ....
  57. ncbi request reprint Change in thrombus length on venous ultrasound and recurrent deep vein thrombosis
    Lori Ann Linkins
    Department of Medicine, McMaster University
    Arch Intern Med 164:1793-6. 2004
    ....
  58. pmc Six-month exercise training program to treat post-thrombotic syndrome: a randomized controlled two-centre trial
    Susan R Kahn
    Department of Medicine, McGill University, Ottawa, Ont, Canada
    CMAJ 183:37-44. 2011
    ....
  59. doi request reprint Risk of recurrence after a first episode of symptomatic venous thromboembolism provoked by a transient risk factor: a systematic review
    Alfonso Iorio
    Department of Internal Medicine, University of Perugia, Italy
    Arch Intern Med 170:1710-6. 2010
    ..We aimed to determine the risk of recurrence for symptomatic venous thromboembolism (VTE) provoked by different transient risk factors...
  60. ncbi request reprint Recurrent venous thrombosis and heparin therapy: an evaluation of the importance of early activated partial thromboplastin times
    S S Anand
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Arch Intern Med 159:2029-32. 1999
    ..The presence of an association between early subtherapeutic activated partial thromboplastin times (aPTTs) and recurrent venous thromboembolism (VTE) remains controversial...
  61. doi request reprint Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial
    Alexander G G Turpie
    McMaster University, Hamilton, Ontario L8L 2X2, Canada
    Lancet 373:1673-80. 2009
    ..We aimed to test the efficacy and safety of oral rivaroxaban for the prevention of venous thromboembolism after total knee arthroplasty...
  62. ncbi request reprint Treatment of deep vein thrombosis
    F Couturaud
    McMaster Clinic, Henderson General Hospital, Hamilton, Ontario, Canada
    Semin Vasc Med 1:43-54. 2001
    ..Catheter-directed thromboylsis, particularly for isolated iliofemoral thrombosis, may be beneficial and needs further evaluation in controlled trials...
  63. ncbi request reprint Natural history of venous thromboembolism
    C Kearon
    McMaster Clinic, Henderson General Hospital, Hamilton, Ontario, Canada
    Semin Vasc Med 1:27-37. 2001
    ....
  64. ncbi request reprint Does the type of hormone replacement therapy influence the risk of deep vein thrombosis? A prospective case-control study
    J D Douketis
    Department of Medicine, McMaster University, Hamilton, Canada
    J Thromb Haemost 3:943-8. 2005
    ..Although hormone replacement therapy (HRT) is associated with an increased risk of deep vein thrombosis (DVT), it is not clear if the risk differs in users of combined estrogen-progestin HRT and estrogen-only HRT...
  65. ncbi request reprint Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients
    S Schulman
    Coagulation Unit, Karolinska University Hospital, Stockholm, Sweden
    J Thromb Haemost 3:692-4. 2005
    ..The intention is to also seek approval of this definition from the regulatory authorities...
  66. ncbi request reprint A randomized trial comparing 5-mg and 10-mg warfarin loading doses
    M A Crowther
    Hamilton Civic Hospitals Research Centre, Ontario, Canada
    Arch Intern Med 159:46-8. 1999
    ....
  67. doi request reprint Intracranial and fatal bleeding according to indication for long-term oral anticoagulant therapy
    L Linkins
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Thromb Haemost 8:2201-7. 2010
    ....
  68. doi request reprint The vexing problem of guidelines and conflict of interest: a potential solution
    Gordon Guyatt
    McMaster University Health Sciences Centre, Henderson General Hospital, Hamilton, Ontario, Canada
    Ann Intern Med 152:738-41. 2010
    ..These strategies may help to achieve the benefits of expert input without conflicts of interest influencing recommendations...
  69. ncbi request reprint Homocysteine-lowering therapy and risk for venous thromboembolism: a randomized trial
    Joel G Ray
    Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Ann Intern Med 146:761-7. 2007
    ..Elevated total homocysteine levels are associated with a higher risk for venous thromboembolism. Whether decreasing homocysteine levels with vitamin therapy reduces the risk for venous thromboembolism is not known...
  70. pmc Diagnosis of pulmonary embolism
    Clive Kearon
    Clinical Thrombosis Service, Henderson General Hospital and Faculty of Health Sciences, McMaster University, Hamilton, ON
    CMAJ 168:183-94. 2003
    ..Helical CT and MRI are rapidly improving as diagnostic tests for pulmonary embolism and are expected to become central to its evaluation...
  71. ncbi request reprint Epidemiology of venous thromboembolism
    C Kearon
    McMaster Clinic, Henderson General Hospital, Hamilton, Ontario, Canada
    Semin Vasc Med 1:7-26. 2001
    ..Risk factors for a first episode of VTE are generally also risk factors for recurrence, although the associated relative risk for thrombosis may differ for a first and subsequent event...
  72. ncbi request reprint Decrease in sensitivity of D-dimer for acute venous thromboembolism after starting anticoagulant therapy
    F Couturaud
    Hamilton Civic Hospitals Research Centre, and McMaster University, Hamilton, Ontario, Canada
    Blood Coagul Fibrinolysis 13:241-6. 2002
    ..0-98.6) to 89.4% (95% confidence interval, 83.7-95.1). There is a decrease in D-dimer levels in patients with acute VTE 24 h after starting heparin therapy that is expected to result in a clinically important drop in sensitivity...
  73. ncbi request reprint Venous thromboembolism in association with features of the metabolic syndrome
    J G Ray
    Department of Medicine, St Michael s Hospital, University of Toronto, Ontario M5B 1W8, Canada
    QJM 100:679-84. 2007
    ..However, whether each of these factors additively increases the risk of VTE is uncertain...
  74. ncbi request reprint Management of suspected deep venous thrombosis in outpatients by using clinical assessment and D-dimer testing
    C Kearon
    McMaster University Clinic, Room 401, Henderson General Hospital, 711 Concession Street; Hamilton, Ontario L8V 1C3, Canada
    Ann Intern Med 135:108-11. 2001
    ..9% to 100%]). CONCLUSION: The combination of a low pretest probability of deep venous thrombosis and a negative result on a whole-blood D -dimer test rules out deep venous thrombosis in a large proportion of symptomatic outpatients...
  75. ncbi request reprint Consensus statements on the risk, prevention, and treatment of venous thromboembolism in inflammatory bowel disease: Canadian Association of Gastroenterology
    Geoffrey C Nguyen
    Mount Sinai Hospital Centre for Inflammatory Bowel Disease, Toronto, Ontario, Canada Department of Medicine, University of Toronto, Toronto, Ontario, Canada Electronic address
    Gastroenterology 146:835-848.e6. 2014
    ..We present recommendations for the prevention and treatment of VTE in patients with IBD...
  76. doi request reprint Myocardial injury after noncardiac surgery: a large, international, prospective cohort study establishing diagnostic criteria, characteristics, predictors, and 30-day outcomes
    Fernando Botto
    From the Hamilton General Hospital, David Braley Cardiac, Vascular, and Stroke Research Institute, Population Health Research Institute, Hamilton, Ontario, Canada P J D and Members of The VISION Writing Group and VISION Investigators, who are listed in appendix 1 and appendix 2, respectively Population Health Research Institute, Hamilton, Ontario, Canada Department of Clinical Research, Estudios Clinicos Latino America ECLA, Rosario, Argentina Biomedical Research Institute Sant Pau IIB Sant Pau, Barcelona, Spain The Chinese University of Hong Kong, Shatin, N T, Hong Kong Universidad Autónoma de Bucaramanga and Fundación Cardioinfantil, Colombia St John s Medical College and Research Institute, Bangalore, India Department of Surgery, University of Manitoba, Winnipeg, Manitoba, Canada Department of Clinical Epidemiology and Biostatistics and Department of Medicine, McMaster University, Hamilton, Ontario, Canada Hospital General Universitario Gregorio Maranon, Madrid, Spain University of Alberta, Edmonton, Alberta, Canada University of Malaya, Kuala Lampur, Malaysia Research Institute Hcor Hospital do Coracao, Sao Paulo, Brazil Barts and The London School of Medicine and Dentistry
    Anesthesiology 120:564-78. 2014
    ..The study's four objectives were to determine the diagnostic criteria, characteristics, predictors, and 30-day outcomes of MINS...
  77. ncbi request reprint A comparison of three rapid D-dimer methods for the diagnosis of venous thromboembolism
    M J Kovacs
    Department of Medicine, London Health Sciences Centre, London, Ontario, Canada
    Br J Haematol 115:140-4. 2001
    ..The SimpliRED D-dimer was found to be less sensitive than the Accuclot or IL-Test. When combined with pre-test probability all three methods are probably acceptable for use in the diagnosis of venous thromboembolism...
  78. ncbi request reprint Use of different D-dimer levels to exclude venous thromboembolism depending on clinical pretest probability
    L A Linkins
    Department of Medicine, Henderson Research Center, McMaster University, Hamilton, Canada
    J Thromb Haemost 2:1256-60. 2004
    ..Use of three pretest probability-specific D-dimer cut-off points rather than a single D-dimer cut-off point for all patients, has the potential to increase the utility of D-dimer testing for the diagnosis of venous thromboembolism...
  79. ncbi request reprint Noninvasive diagnosis of deep vein thrombosis in postoperative patients
    C Kearon
    McMaster University Clinic, Henderson General Hospital, Hamilton, Ontario, Canada
    Semin Thromb Hemost 27:3-8. 2001
    ..Coupled with the comparatively low accuracy of noninvasive testing for asymptomatic DVT, this suggests that the results of such testing are unsuitable for the evaluation of new methods of prophylaxis in clinical trials...
  80. doi request reprint Differences in clinical presentation of deep vein thrombosis in men and women
    E Roseann Andreou
    McMaster University, Henderson Research Centre, Hamilton, ON, Canada
    J Thromb Haemost 6:1713-9. 2008
    ..As assessment of clinical pretest probability is the first step in the diagnostic evaluation of deep vein thrombosis (DVT), it is important to know if the clinical features of DVT are the same in men and women...
  81. ncbi request reprint Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer
    P S Wells
    Department of Medicine, University of Ottawa, Ontario, Canada
    Thromb Haemost 83:416-20. 2000
    ..The combination of a score < or =4.0 by our simple clinical prediction rule and a negative SimpliRED D-Dimer result may safely exclude PE in a large proportion of patients with suspected PE...
  82. ncbi request reprint Clinical utility of a rapid whole-blood D-dimer assay in patients with cancer who present with suspected acute deep venous thrombosis
    A Y Lee
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 131:417-23. 1999
    ..Although D-dimer assays have high negative predictive values for the diagnosis of deep venous thrombosis, their accuracy in patients with cancer is uncertain...
  83. ncbi request reprint Perioperative management of patients receiving oral anticoagulants
    Clive Kearon
    Arch Intern Med 163:2532-3; author reply 2533. 2003
  84. ncbi request reprint Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden
    Francis Couturaud
    GETBO, EA 3878, Department of Internal Medicine and Chest Diseases, University Hospital Centre La Cavale Blanche, 29609 Brest, Cedex, France
    Thromb Haemost 96:744-9. 2006
    ..FVL is associated with a two- to threefold increase in VTE in first-degree relatives of patients with VTE. No subgroup of relatives was identified who require more than routine prophylaxis because of a particularly high risk of VTE...
  85. ncbi request reprint Deep vein thrombosis
    Clive Kearon
    Lancet 366:118; author reply 119-20. 2005
  86. ncbi request reprint Early postoperative anticoagulation after mechanical valve replacement: a systematic review
    Alexander Kulik
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa Hospital, Ottawa, Canada
    Ann Thorac Surg 81:770-81. 2006
    ....
  87. ncbi request reprint Hemorrhagic complications of anticoagulant treatment: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
    Mark N Levine
    Henderson Research Centre, 711 Concession St, Hamilton, Ontario L8V 1C3
    Chest 126:287S-310S. 2004
    ..In terms of treatment decision making for anticoagulant therapy, bleeding risk cannot be considered alone, ie, the potential decrease in thromboembolism must be balanced against the potential increased bleeding risk...
  88. ncbi request reprint Effect of patient's sex on risk of recurrent venous thromboembolism: a meta-analysis
    Simon McRae
    Department of Haematology and Oncology, Queen Elizabeth Hospital, Woodville, Australia
    Lancet 368:371-8. 2006
    ..We did a meta-analysis to assess from available evidence whether men and women have the same risk of recurrent venous thromboembolism after stopping anticoagulant treatment...
  89. ncbi request reprint Epidemiology of postoperative venous thromboembolism: lessons from an administrative data base
    Clive Kearon
    Thromb Haemost 90:367-8. 2003