Research Topics
| C KaushicSummaryAffiliation: McMaster University Country: Canada Publications
| Collaborators
|
Detail Information
Publications
Primary human epithelial cell culture system for studying interactions between female upper genital tract and sexually transmitted viruses, HSV-2 and HIV-1Charu Kaushic
McMaster Immunology Research Center, McMaster University, Department of Pathology and Molecular Medicine, 1280 Main Street West, Hamilton, Ontario, Canada L8S4K1
Methods 55:114-21. 2011..Prospective use of these cultures to re-create the microenvironment in the reproductive tract is discussed...- Increased prevalence of sexually transmitted viral infections in women: the role of female sex hormones in regulating susceptibility and immune responsesCharu Kaushic
Department of Pathology and Molecular Medicine, Michael DeGroote Center for Learning and Discovery, McMaster University, Hamilton, Ontario, Canada
J Reprod Immunol 88:204-9. 2011..Manipulating the microenvironment of the female genital tract with sex hormones may contribute to the development of improved immunization strategies against sexually transmitted infections... 
Effects of estradiol and progesterone on susceptibility and early immune responses to Chlamydia trachomatis infection in the female reproductive tractC Kaushic
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Infect Immun 68:4207-16. 2000..Our data demonstrate that hormone environment, at the time of infection, has a profound effect on the outcome of microbial infection in the female reproductive tract...
Infection of polarized primary epithelial cells from rat uterus with Chlamydia trachomatis: cell-cell interaction and cytokine secretionC Kaushic
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03766, USA
Am J Reprod Immunol 44:73-9. 2000..The objective of this study was to examine the susceptibility of rat uterine epithelial cells (UEC) to infection with Chlamydia trachomatis and to study the epithelial-stromal interactions following infection...- Progesterone increases susceptibility and decreases immune responses to genital herpes infectionCharu Kaushic
Department of Pathology and Molecular Medicine, Center of Gene Therapeutics, McMaster University Health Sciences Center, Hamilton, Ontario, Canada
J Virol 77:4558-65. 2003..Animal models and vaccine strategies for sexually transmitted diseases need to consider the effect of hormone treatments on susceptibility and immune responses... - HIV-1 infection in the female reproductive tract: role of interactions between HIV-1 and genital epithelial cellsCharu Kaushic
Department of Pathology and Molecular Medicine, Michael DeGroote Center for Learning and Discovery, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
Am J Reprod Immunol 65:253-60. 2011..Further understanding of GEC responses to HIV-1 and their regulation could be critical to understanding HIV-1 transmission dynamics during heterosexual transmission... - HIV infection in the female genital tract: discrete influence of the local mucosal microenvironmentCharu Kaushic
Center for Gene Therapeutics, Michael G DeGroote Institute of Infectious Diseases Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
Am J Reprod Immunol 63:566-75. 2010.... - The role of the local microenvironment in regulating susceptibility and immune responses to sexually transmitted viruses in the female genital tractCharu Kaushic
Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, Michael G DeGroote Center for Learning and Discovery Room 4014, McMaster University, Ontario, Canada
J Reprod Immunol 83:168-72. 2009.... - Polymeric immunoglobulin A receptor in the rodent female reproductive tract: influence of estradiol in the vagina and differential expression of messenger ribonucleic acid during estrous cycleC Kaushic
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Biol Reprod 57:958-66. 1997..These findings demonstrate that pIgR is synthesized locally in the uterus and vagina and is under tissue-specific hormone regulation... - Chlamydia trachomatis infection in the female reproductive tract of the rat: influence of progesterone on infectivity and immune responseC Kaushic
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756 0001, USA
Infect Immun 66:893-8. 1998..Further, they suggest that clearance of the infection from the reproductive tract involves immune cells from the LN draining the reproductive tract... - Protection against genital herpes infection in mice immunized under different hormonal conditions correlates with induction of vagina-associated lymphoid tissueAmy E Gillgrass
Department of Pathology, MDCL 4014, McMaster University, 1200 Main St. West, Hamilton, Ontario, Canada
J Virol 79:3117-26. 2005..The S-treated group of mice also had high gB-specific IgG titers. These studies show that sex hormones modify the induction of protective immune responses following IVAG immunization... - Prolonged exposure to progesterone prevents induction of protective mucosal responses following intravaginal immunization with attenuated herpes simplex virus type 2Amy E Gillgrass
Center of Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Center 4H30F, 1200 Main Street West, Hamilton, Ontario, Canada L8P 3Z5
J Virol 77:9845-51. 2003..These results indicate that longer exposure to Depo leads to poor innate and adaptive immune responses to HSV-2 that fail to protect mice from subsequent genital challenges... - Differential responses of murine vaginal and uterine epithelial cells prior to and following herpes simplex virus type 2 (HSV-2) infectionSherie Fernandez
Center for Gene Therapeutics, Department of Pathology and Molecular Medicine, Michael G DeGroote Center for Learning and Discovery, Hamilton, Ontario, Canada
Am J Reprod Immunol 57:367-77. 2007.... - Intranasal and subcutaneous immunization under the effect of estradiol leads to better protection against genital HSV-2 challenge compared to progesteroneSudha Bhavanam
Center for Gene Therapeutics, Michael G DeGroote Center for Learning and Discovery, Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
Vaccine 26:6165-72. 2008..Female sex hormones can influence immune responses and outcome of viral challenge in the genital tract following systemic immunization... - Estradiol regulates susceptibility following primary exposure to genital herpes simplex virus type 2, while progesterone induces inflammationAmy E Gillgrass
Department of Pathology, Center for Gene Therapeutics, MDCL 4014, McMaster University, 1200 Main St. West, Hamilton, Ontario, Canada
J Virol 79:3107-16. 2005..The results show that sex hormones regulate initiation of infection and immune responses to genital HSV-2 infection... - Susceptibility of human female primary genital epithelial cells to herpes simplex virus, type-2 and the effect of TLR3 ligand and sex hormones on infectionErin M MacDonald
Center for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Michael G DeGroote Center for Learning and Discovery, Hamilton, Ontario, Canada L8P 3Z5
Biol Reprod 77:1049-59. 2007..The results provide valuable information regarding the susceptibility of women's genital ECs to HSV-2 and the ability of innate immunity and hormones to modify this susceptibility... - Estradiol limits viral replication following intravaginal immunization leading to diminished mucosal IgG response and non-sterile protection against genital herpes challengeAmy Gillgrass
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
Am J Reprod Immunol 63:299-309. 2010..In this study, we determined the outcome of immunization after the thickening of vaginal epithelium following E-treatment waned. OVX, C57BL/6 mice were given Progesterone (P), E or saline (S) for 3 days and immunized with IVAG TK-HSV-2... - Influenza infection leads to increased susceptibility to subsequent bacterial superinfection by impairing NK cell responses in the lungCherrie Lee Small
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
J Immunol 184:2048-56. 2010..aureus phagocytosis by alveolar macrophages. Together, our study identifies the weakened NK cell response in the lung to be a novel critical mechanism for flu-mediated susceptibility to bacterial superinfection... - Differential induction of innate anti-viral responses by TLR ligands against Herpes simplex virus, type 2, infection in primary genital epithelium of womenAisha Nazli
Center for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Michael G DeGroote Center for Learning and Discovery, Hamilton, Ontario, Canada L8N 3Z5
Antiviral Res 81:103-12. 2009..Anti-viral responses induced by TLR ligands in GECs may provide a unique alternative to topical microbicides by enhancing body's own mucosal innate defense mechanisms against sexually transmitted viruses... - Expression of Toll-like receptors in murine vaginal epithelium is affected by the estrous cycle and stromal cellsXiao Dan Yao
Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, MDCL 4019, Hamilton, Ontario, Canada
J Reprod Immunol 75:106-19. 2007..These findings contribute to our understanding of innate immune defense against STIs and enhance the quality of woman's reproductive health... - Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocationAisha Nazli
Center for Gene Therapeutics, Michael G DeGroote Center for Learning and Discovery, McMaster University, Hamilton, Ontario, Canada
PLoS Pathog 6:e1000852. 2010..This mechanism could be particularly relevant to mucosal transmission of HIV-1 as well as immune activation seen in HIV-1 infected individuals...