C Kaushic

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. doi request reprint Primary human epithelial cell culture system for studying interactions between female upper genital tract and sexually transmitted viruses, HSV-2 and HIV-1
    Charu Kaushic
    McMaster Immunology Research Center, McMaster University, Department of Pathology and Molecular Medicine, 1280 Main Street West, Hamilton, Ontario, Canada L8S4K1
    Methods 55:114-21. 2011
  2. doi request reprint HIV infection in the female genital tract: discrete influence of the local mucosal microenvironment
    Charu Kaushic
    Center for Gene Therapeutics, Michael G DeGroote Institute of Infectious Diseases Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Reprod Immunol 63:566-75. 2010
  3. doi request reprint HIV-1 infection in the female reproductive tract: role of interactions between HIV-1 and genital epithelial cells
    Charu Kaushic
    Department of Pathology and Molecular Medicine, Michael DeGroote Center for Learning and Discovery, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    Am J Reprod Immunol 65:253-60. 2011
  4. doi request reprint Increased prevalence of sexually transmitted viral infections in women: the role of female sex hormones in regulating susceptibility and immune responses
    Charu Kaushic
    Department of Pathology and Molecular Medicine, Michael DeGroote Center for Learning and Discovery, McMaster University, Hamilton, Ontario, Canada
    J Reprod Immunol 88:204-9. 2011
  5. doi request reprint The role of the local microenvironment in regulating susceptibility and immune responses to sexually transmitted viruses in the female genital tract
    Charu Kaushic
    Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, Michael G DeGroote Center for Learning and Discovery Room 4014, McMaster University, Ontario, Canada
    J Reprod Immunol 83:168-72. 2009
  6. pmc Progesterone increases susceptibility and decreases immune responses to genital herpes infection
    Charu Kaushic
    Department of Pathology and Molecular Medicine, Center of Gene Therapeutics, McMaster University Health Sciences Center, Hamilton, Ontario, Canada
    J Virol 77:4558-65. 2003
  7. ncbi request reprint Infection of polarized primary epithelial cells from rat uterus with Chlamydia trachomatis: cell-cell interaction and cytokine secretion
    C Kaushic
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03766, USA
    Am J Reprod Immunol 44:73-9. 2000
  8. pmc Effects of estradiol and progesterone on susceptibility and early immune responses to Chlamydia trachomatis infection in the female reproductive tract
    C Kaushic
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Infect Immun 68:4207-16. 2000
  9. ncbi request reprint Polymeric immunoglobulin A receptor in the rodent female reproductive tract: influence of estradiol in the vagina and differential expression of messenger ribonucleic acid during estrous cycle
    C Kaushic
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Biol Reprod 57:958-66. 1997
  10. pmc Chlamydia trachomatis infection in the female reproductive tract of the rat: influence of progesterone on infectivity and immune response
    C Kaushic
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756 0001, USA
    Infect Immun 66:893-8. 1998

Collaborators

  • Kenneth L Rosenthal
  • A D Murdin
  • H Jiang
  • Ali A Ashkar
  • Petra Arck
  • Z Xing
  • Michel J Tremblay
  • Amy E Gillgrass
  • Aisha Nazli
  • Amy Gillgrass
  • Sherie Fernandez
  • Sudha Bhavanam
  • Xiao Dan Yao
  • K L Roth
  • Cherrie Lee Small
  • Marek Smieja
  • Erin M MacDonald
  • K Ho
  • S Bhavanam
  • A Gillgrass
  • V H Ferreira
  • Earl G Brown
  • Daniela Damjanovic
  • Manel Jordana
  • Sarah McCormick
  • Olivia Chan
  • Scott D Gray-Owen
  • Christopher R Shaler
  • Wendy N Dobson-Belaire
  • Mangalakumari Jeyanathan
  • A Larry Arsenault
  • Michel Ouellet
  • Duncan Chege
  • Denis P Snider
  • Alison Savoy
  • Margaret M Kelly
  • Vera A Tang
  • Kate M Towarnicki
  • Sherie A Fernandez

Detail Information

Publications22

  1. doi request reprint Primary human epithelial cell culture system for studying interactions between female upper genital tract and sexually transmitted viruses, HSV-2 and HIV-1
    Charu Kaushic
    McMaster Immunology Research Center, McMaster University, Department of Pathology and Molecular Medicine, 1280 Main Street West, Hamilton, Ontario, Canada L8S4K1
    Methods 55:114-21. 2011
    ..Prospective use of these cultures to re-create the microenvironment in the reproductive tract is discussed...
  2. doi request reprint HIV infection in the female genital tract: discrete influence of the local mucosal microenvironment
    Charu Kaushic
    Center for Gene Therapeutics, Michael G DeGroote Institute of Infectious Diseases Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Reprod Immunol 63:566-75. 2010
    ....
  3. doi request reprint HIV-1 infection in the female reproductive tract: role of interactions between HIV-1 and genital epithelial cells
    Charu Kaushic
    Department of Pathology and Molecular Medicine, Michael DeGroote Center for Learning and Discovery, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    Am J Reprod Immunol 65:253-60. 2011
    ..Further understanding of GEC responses to HIV-1 and their regulation could be critical to understanding HIV-1 transmission dynamics during heterosexual transmission...
  4. doi request reprint Increased prevalence of sexually transmitted viral infections in women: the role of female sex hormones in regulating susceptibility and immune responses
    Charu Kaushic
    Department of Pathology and Molecular Medicine, Michael DeGroote Center for Learning and Discovery, McMaster University, Hamilton, Ontario, Canada
    J Reprod Immunol 88:204-9. 2011
    ..Manipulating the microenvironment of the female genital tract with sex hormones may contribute to the development of improved immunization strategies against sexually transmitted infections...
  5. doi request reprint The role of the local microenvironment in regulating susceptibility and immune responses to sexually transmitted viruses in the female genital tract
    Charu Kaushic
    Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, Michael G DeGroote Center for Learning and Discovery Room 4014, McMaster University, Ontario, Canada
    J Reprod Immunol 83:168-72. 2009
    ....
  6. pmc Progesterone increases susceptibility and decreases immune responses to genital herpes infection
    Charu Kaushic
    Department of Pathology and Molecular Medicine, Center of Gene Therapeutics, McMaster University Health Sciences Center, Hamilton, Ontario, Canada
    J Virol 77:4558-65. 2003
    ..Animal models and vaccine strategies for sexually transmitted diseases need to consider the effect of hormone treatments on susceptibility and immune responses...
  7. ncbi request reprint Infection of polarized primary epithelial cells from rat uterus with Chlamydia trachomatis: cell-cell interaction and cytokine secretion
    C Kaushic
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03766, USA
    Am J Reprod Immunol 44:73-9. 2000
    ..The objective of this study was to examine the susceptibility of rat uterine epithelial cells (UEC) to infection with Chlamydia trachomatis and to study the epithelial-stromal interactions following infection...
  8. pmc Effects of estradiol and progesterone on susceptibility and early immune responses to Chlamydia trachomatis infection in the female reproductive tract
    C Kaushic
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Infect Immun 68:4207-16. 2000
    ..Our data demonstrate that hormone environment, at the time of infection, has a profound effect on the outcome of microbial infection in the female reproductive tract...
  9. ncbi request reprint Polymeric immunoglobulin A receptor in the rodent female reproductive tract: influence of estradiol in the vagina and differential expression of messenger ribonucleic acid during estrous cycle
    C Kaushic
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Biol Reprod 57:958-66. 1997
    ..These findings demonstrate that pIgR is synthesized locally in the uterus and vagina and is under tissue-specific hormone regulation...
  10. pmc Chlamydia trachomatis infection in the female reproductive tract of the rat: influence of progesterone on infectivity and immune response
    C Kaushic
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756 0001, USA
    Infect Immun 66:893-8. 1998
    ..Further, they suggest that clearance of the infection from the reproductive tract involves immune cells from the LN draining the reproductive tract...
  11. pmc Prolonged exposure to progesterone prevents induction of protective mucosal responses following intravaginal immunization with attenuated herpes simplex virus type 2
    Amy E Gillgrass
    Center of Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Center 4H30F, 1200 Main Street West, Hamilton, Ontario, Canada L8P 3Z5
    J Virol 77:9845-51. 2003
    ..These results indicate that longer exposure to Depo leads to poor innate and adaptive immune responses to HSV-2 that fail to protect mice from subsequent genital challenges...
  12. pmc Protection against genital herpes infection in mice immunized under different hormonal conditions correlates with induction of vagina-associated lymphoid tissue
    Amy E Gillgrass
    Department of Pathology, MDCL 4014, McMaster University, 1200 Main St West, Hamilton, Ontario, Canada
    J Virol 79:3117-26. 2005
    ..The S-treated group of mice also had high gB-specific IgG titers. These studies show that sex hormones modify the induction of protective immune responses following IVAG immunization...
  13. doi request reprint Intranasal and subcutaneous immunization under the effect of estradiol leads to better protection against genital HSV-2 challenge compared to progesterone
    Sudha Bhavanam
    Center for Gene Therapeutics, Michael G DeGroote Center for Learning and Discovery, Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    Vaccine 26:6165-72. 2008
    ..Female sex hormones can influence immune responses and outcome of viral challenge in the genital tract following systemic immunization...
  14. pmc Estradiol regulates susceptibility following primary exposure to genital herpes simplex virus type 2, while progesterone induces inflammation
    Amy E Gillgrass
    Department of Pathology, Center for Gene Therapeutics, MDCL 4014, McMaster University, 1200 Main St West, Hamilton, Ontario, Canada
    J Virol 79:3107-16. 2005
    ..The results show that sex hormones regulate initiation of infection and immune responses to genital HSV-2 infection...
  15. ncbi request reprint Differential responses of murine vaginal and uterine epithelial cells prior to and following herpes simplex virus type 2 (HSV-2) infection
    Sherie Fernandez
    Center for Gene Therapeutics, Department of Pathology and Molecular Medicine, Michael G DeGroote Center for Learning and Discovery, Hamilton, Ontario, Canada
    Am J Reprod Immunol 57:367-77. 2007
    ....
  16. ncbi request reprint Susceptibility of human female primary genital epithelial cells to herpes simplex virus, type-2 and the effect of TLR3 ligand and sex hormones on infection
    Erin M MacDonald
    Center for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Michael G DeGroote Center for Learning and Discovery, Hamilton, Ontario, Canada L8P 3Z5
    Biol Reprod 77:1049-59. 2007
    ..The results provide valuable information regarding the susceptibility of women's genital ECs to HSV-2 and the ability of innate immunity and hormones to modify this susceptibility...
  17. doi request reprint Estradiol limits viral replication following intravaginal immunization leading to diminished mucosal IgG response and non-sterile protection against genital herpes challenge
    Amy Gillgrass
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Am J Reprod Immunol 63:299-309. 2010
    ..In this study, we determined the outcome of immunization after the thickening of vaginal epithelium following E-treatment waned. OVX, C57BL/6 mice were given Progesterone (P), E or saline (S) for 3 days and immunized with IVAG TK-HSV-2...
  18. doi request reprint Delayed but effective induction of mucosal memory immune responses against genital HSV-2 in the absence of secondary lymphoid organs
    K L Roth
    McMaster Immunology Research Center, Michael G DeGroote Center for Learning and Discovery, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Mucosal Immunol 6:56-68. 2013
    ..This will inform new strategies to design mucosal vaccines against sexually transmitted infections...
  19. ncbi request reprint Expression of Toll-like receptors in murine vaginal epithelium is affected by the estrous cycle and stromal cells
    Xiao Dan Yao
    Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, MDCL 4019, Hamilton, Ontario, Canada
    J Reprod Immunol 75:106-19. 2007
    ..These findings contribute to our understanding of innate immune defense against STIs and enhance the quality of woman's reproductive health...
  20. doi request reprint Differential induction of innate anti-viral responses by TLR ligands against Herpes simplex virus, type 2, infection in primary genital epithelium of women
    Aisha Nazli
    Center for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Michael G DeGroote Center for Learning and Discovery, Hamilton, Ontario, Canada L8N 3Z5
    Antiviral Res 81:103-12. 2009
    ..Anti-viral responses induced by TLR ligands in GECs may provide a unique alternative to topical microbicides by enhancing body's own mucosal innate defense mechanisms against sexually transmitted viruses...
  21. doi request reprint Influenza infection leads to increased susceptibility to subsequent bacterial superinfection by impairing NK cell responses in the lung
    Cherrie Lee Small
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
    J Immunol 184:2048-56. 2010
    ..aureus phagocytosis by alveolar macrophages. Together, our study identifies the weakened NK cell response in the lung to be a novel critical mechanism for flu-mediated susceptibility to bacterial superinfection...
  22. pmc Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation
    Aisha Nazli
    Center for Gene Therapeutics, Michael G DeGroote Center for Learning and Discovery, McMaster University, Hamilton, Ontario, Canada
    PLoS Pathog 6:e1000852. 2010
    ..This mechanism could be particularly relevant to mucosal transmission of HIV-1 as well as immune activation seen in HIV-1 infected individuals...