Manel Jordana

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. pmc A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure
    Alba Llop-Guevara
    Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Hamilton, Ontario, Canada
    PLoS ONE 9:e88714. 2014
  2. ncbi request reprint Transforming growth factor-beta regulates house dust mite-induced allergic airway inflammation but not airway remodeling
    Ramzi Fattouh
    Department of Pathology and Molecular Medicine, Head, Division of Respiratory Diseases and Allergy, MDCL 4013, McMaster University, 1200 Main Street West, Hamilton, ON, Canada
    Am J Respir Crit Care Med 177:593-603. 2008
  3. ncbi request reprint Divergent immune responses to house dust mite lead to distinct structural-functional phenotypes
    Jill R Johnson
    Department of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 293:L730-9. 2007
  4. ncbi request reprint B7RP-1 is not required for the generation of Th2 responses in a model of allergic airway inflammation but is essential for the induction of inhalation tolerance
    Beata U Gajewska
    Department of Pathology and Molecular Medicine, and Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    J Immunol 174:3000-5. 2005
  5. ncbi request reprint Th2 differentiation in distinct lymph nodes influences the site of mucosal Th2 immune-inflammatory responses
    David Alvarez
    Department of Pathology and Molecular Medicine, Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    J Immunol 179:3287-96. 2007
  6. ncbi request reprint Inhalation tolerance is induced selectively in thoracic lymph nodes but executed pervasively at distant mucosal and nonmucosal tissues
    David Alvarez
    Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, Master University, Hamilton, Ontario, Canada
    J Immunol 176:2568-80. 2006
  7. doi request reprint IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization
    Derek K Chu
    Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 131:187-200.e1-8. 2013
  8. ncbi request reprint Mainstream cigarette smoke exposure attenuates airway immune inflammatory responses to surrogate and common environmental allergens in mice, despite evidence of increased systemic sensitization
    Clinton S Robbins
    Department of Pathology, Center for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    J Immunol 175:2834-42. 2005
  9. ncbi request reprint House dust mite facilitates ovalbumin-specific allergic sensitization and airway inflammation
    Ramzi Fattouh
    Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 172:314-21. 2005
  10. ncbi request reprint Effect of GM-CSF on immune, inflammatory, and clinical responses to ragweed in a novel mouse model of mucosal sensitization
    Elizabeth C Cates
    Department of Pathology and Molecular Medicine and the Centre for Gene Therapeutics, Division of Respiratory Diseases and Allergy, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 111:1076-86. 2003

Collaborators

Detail Information

Publications42

  1. pmc A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure
    Alba Llop-Guevara
    Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Hamilton, Ontario, Canada
    PLoS ONE 9:e88714. 2014
    ....
  2. ncbi request reprint Transforming growth factor-beta regulates house dust mite-induced allergic airway inflammation but not airway remodeling
    Ramzi Fattouh
    Department of Pathology and Molecular Medicine, Head, Division of Respiratory Diseases and Allergy, MDCL 4013, McMaster University, 1200 Main Street West, Hamilton, ON, Canada
    Am J Respir Crit Care Med 177:593-603. 2008
    ..Transforming growth factor (TGF)-beta is a powerful regulator of both the tissue repair and inflammatory responses, and numerous experimental and clinical studies suggest that it may play an integral role in the pathogenesis of asthma...
  3. ncbi request reprint Divergent immune responses to house dust mite lead to distinct structural-functional phenotypes
    Jill R Johnson
    Department of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 293:L730-9. 2007
    ..These data show that distinct structural-functional phenotypes associated with chronic airway inflammation are strictly dependent on the nature of the immune-inflammatory response...
  4. ncbi request reprint B7RP-1 is not required for the generation of Th2 responses in a model of allergic airway inflammation but is essential for the induction of inhalation tolerance
    Beata U Gajewska
    Department of Pathology and Molecular Medicine, and Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    J Immunol 174:3000-5. 2005
    ..In summary, our results demonstrate that in a model of mucosal allergic sensitization, the ICOS-B7RP-1 pathway is redundant for the generation of Th2 responses but essential for the induction of inhalation tolerance...
  5. ncbi request reprint Th2 differentiation in distinct lymph nodes influences the site of mucosal Th2 immune-inflammatory responses
    David Alvarez
    Department of Pathology and Molecular Medicine, Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    J Immunol 179:3287-96. 2007
    ..These data suggest that the site of initial Th2 differentiation and differential homing molecule expression restricts Th2 immune-inflammatory responses to mucosal, but not cutaneous, tissues...
  6. ncbi request reprint Inhalation tolerance is induced selectively in thoracic lymph nodes but executed pervasively at distant mucosal and nonmucosal tissues
    David Alvarez
    Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, Master University, Hamilton, Ontario, Canada
    J Immunol 176:2568-80. 2006
    ..These data indicate that while inhalation tolerance is selectively induced in local thoracic LNs, its tolerogenic activity resides systemically and leads to pervasive immune tolerance in distant mucosal and nonmucosal sites...
  7. doi request reprint IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization
    Derek K Chu
    Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 131:187-200.e1-8. 2013
    ..The epithelium-associated cytokines thymic stromal lymphopoietin (TSLP), IL-25, and IL-33 are suggested to be important for the initiation of these responses...
  8. ncbi request reprint Mainstream cigarette smoke exposure attenuates airway immune inflammatory responses to surrogate and common environmental allergens in mice, despite evidence of increased systemic sensitization
    Clinton S Robbins
    Department of Pathology, Center for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    J Immunol 175:2834-42. 2005
    ..MTS, therefore, plays a disparate role in the development of allergic responses, inducing a heightened state of allergen-specific sensitization, but dampening local immune inflammatory processes in the lung...
  9. ncbi request reprint House dust mite facilitates ovalbumin-specific allergic sensitization and airway inflammation
    Ramzi Fattouh
    Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 172:314-21. 2005
    ..Although these models typically investigate responses to a single antigen or allergen, humans are frequently exposed to a myriad of allergens, each with distinct antigenic potential...
  10. ncbi request reprint Effect of GM-CSF on immune, inflammatory, and clinical responses to ragweed in a novel mouse model of mucosal sensitization
    Elizabeth C Cates
    Department of Pathology and Molecular Medicine and the Centre for Gene Therapeutics, Division of Respiratory Diseases and Allergy, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 111:1076-86. 2003
    ..Here we have investigated the effect of respiratory mucosal exposure to a ragweed extract in the absence of chemical adjuvant on the generation of allergic responses...
  11. ncbi request reprint Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions
    Katherine Arias
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 124:307-14, 314.e1-2. 2009
    ..Fatality registries place peanut as the most common culprit of fatal and near-fatal reactions in North America. Because prophylaxis and treatment have advanced little in recent years, it is imperative to evaluate novel therapies...
  12. ncbi request reprint Cutaneous antigen priming via gene gun leads to skin-selective Th2 immune-inflammatory responses
    David Alvarez
    Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    J Immunol 174:1664-74. 2005
    ..These data indicate that Ag exposure to the skin leads to Th2 differentiation within skin-draining lymph nodes and subsequent Th2 immunity that is selectively manifested in the skin...
  13. doi request reprint Cigarette smoke differentially affects eosinophilia and remodeling in a model of house dust mite asthma
    Fernando M Botelho
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, 1200 Main Street West, Hamilton, ON, L8N 3Z5 Canada
    Am J Respir Cell Mol Biol 45:753-60. 2011
    ..Our findings demonstrate that cigarette smoke affects eosinophil migration without affecting airway resistance or modifying Th2 cell adaptive immunity in a murine model of HDM-induced asthma...
  14. ncbi request reprint Modeling responses to respiratory house dust mite exposure
    Elizabeth C Cates
    Department of Pathology and Molecular Medicine, Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Contrib Microbiol 14:42-67. 2007
    ..Here, we will discuss this issue, along with giving critical thought to the use of experimental models...
  15. ncbi request reprint Impact of CD40 ligand, B cells, and mast cells in peanut-induced anaphylactic responses
    Jiangfeng Sun
    Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Immunol 179:6696-703. 2007
    ....
  16. ncbi request reprint Transient corticosteroid treatment permanently amplifies the Th2 response in a murine model of asthma
    Ryan E Wiley
    Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Immunol 172:4995-5005. 2004
    ....
  17. ncbi request reprint Evaluation of inducible costimulator/B7-related protein-1 as a therapeutic target in a murine model of allergic airway inflammation
    Ryan E Wiley
    Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Cell Mol Biol 28:722-30. 2003
    ..This study provides in vivo evidence of an exacerbated long-term immune-inflammatory response following acute ICOS blockade, and suggests that ICOS costimulation is functionally redundant in established allergic disease...
  18. ncbi request reprint Acute, but not resolved, influenza A infection enhances susceptibility to house dust mite-induced allergic disease
    Amal A Al-Garawi
    Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Immunol 182:3095-104. 2009
    ..Thus, the proinflammatory environment established during an acute influenza A infection enhances Th2-polarized immunity to a low dose of HDM and precipitates marked lung dysfunction...
  19. doi request reprint Eosinophils are dispensable for allergic remodeling and immunity in a model of house dust mite-induced airway disease
    Ramzi Fattouh
    Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 183:179-88. 2011
    ..However, direct evidence in support of this notion is limited and often controversial...
  20. ncbi request reprint Intranasal exposure of mice to house dust mite elicits allergic airway inflammation via a GM-CSF-mediated mechanism
    Elizabeth C Cates
    Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, Division of Respiratory Diseases and Allergy, McMaster University, 1200 Main Street, Hamilton, Ontario, Canada L8S 3Z5
    J Immunol 173:6384-92. 2004
    ..Thus, intranasal delivery of HDM results in Th2 sensitization and airway eosinophilic inflammation that appear to be mediated, at least in part, by endogenous GM-CSF production...
  21. pmc In vivo-to-in silico iterations to investigate aeroallergen-host interactions
    Alba Llop-Guevara
    Department of Pathology and Molecular Medicine, Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 3:e2426. 2008
    ....
  22. doi request reprint Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice
    Katherine Arias
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 127:1552-61.e1. 2011
    ..Food-induced anaphylaxis is often a severe allergic reaction characterized by multiorgan dysfunction and a potentially fatal outcome...
  23. doi request reprint Shifting of immune responsiveness to house dust mite by influenza A infection: genomic insights
    Amal Al-Garawi
    Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    J Immunol 188:832-43. 2012
    ..We propose that influenza A infection primes the lung environment in such a way as to lower the threshold of allergen responsiveness, thus facilitating the emergence of a clinically significant allergic phenotype...
  24. doi request reprint Combined budesonide/formoterol therapy in conjunction with allergen avoidance ameliorates house dust mite-induced airway remodeling and dysfunction
    Jill R Johnson
    Department of Pathology and Molecular Medicine, Michael G DeGroote Centre for Learning and Discovery, McMaster University, 1200 Main St West, Hamilton, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 295:L780-8. 2008
    ....
  25. pmc Differential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammation
    Jake K Nikota
    1Medical Sciences Graduate Program, McMaster University, Hamilton, ON, Canada
    Respir Res 12:39. 2011
    ....
  26. ncbi request reprint GM-CSF and dendritic cells in allergic airway inflammation: basic mechanisms and prospects for therapeutic intervention
    Beata U Gajewska
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Curr Drug Targets Inflamm Allergy 2:279-92. 2003
    ..Understanding these interactions may, therefore, afford insight into prospective therapeutic interventions to circumvent, and even reverse the allergic diathesis...
  27. ncbi request reprint TGF-beta, eosinophils and IL-13 in allergic airway remodeling: a critical appraisal with therapeutic considerations
    Ramzi Fattouh
    Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics and Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    Inflamm Allergy Drug Targets 7:224-36. 2008
    ....
  28. pmc Generation and characterization of B7-H4/B7S1/B7x-deficient mice
    Woong Kyung Suh
    Campbell Family Institute for Breast Cancer Research, 620 University Ave, Suite 706, Toronto, Ontario, Canada
    Mol Cell Biol 26:6403-11. 2006
    ..These results suggest that B7-H4 is one of multiple negative cosignaling molecules that collectively provide a fine-tuning mechanism for T-cell-mediated immune responses...
  29. doi request reprint A mouse model of airway disease: oncostatin M-induced pulmonary eosinophilia, goblet cell hyperplasia, and airway hyperresponsiveness are STAT6 dependent, and interstitial pulmonary fibrosis is STAT6 independent
    Dominik K Fritz
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Immunol 186:1107-18. 2011
    ....
  30. ncbi request reprint Interleukin-13-dependent expression of matrix metalloproteinase-12 is required for the development of airway eosinophilia in mice
    Mahmoud A Pouladi
    McMaster University, Department of Pathology and Molecular Medicine, Health Sciences Centre, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada
    Am J Respir Cell Mol Biol 30:84-90. 2004
    ..Using interleukin-13 KO mice, we demonstrated that expression of MMP-12 is interleukin-13-dependent. Collectively, our data indicate a novel function for MMP-12 in the process of airway eosinophil accumulation...
  31. ncbi request reprint Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo
    Derek K Chu
    McMaster Immunology Research Centre MIRC, Department of Pathology and Molecular Medicine, and Department of Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Exp Med 211:1657-72. 2014
    ..Thus, eosinophils can be critical contributors to the intestinal immune system, and granule-mediated shaping of DC responses can promote both intestinal and extraintestinal adaptive immunity. ..
  32. ncbi request reprint Granulocyte macrophage colony-stimulating factor-driven respiratory mucosal sensitization induces Th2 differentiation and function independently of interleukin-4
    Stacey A Ritz
    Department of Pathology and Molecular Medicine and Centre for Gene Therapeutics, Division of Respiratory Diseases and Allergy, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Cell Mol Biol 27:428-35. 2002
    ..We conclude that IL-4 is not required for the generation of Th2-polarized responses in the presence of GM-CSF...
  33. doi request reprint Critical role of natural killer cells in lung immunopathology during influenza infection in mice
    Mohamed F Abdul-Careem
    McMaster Immunology Research Centre and Institute for Infectious Diseases Research, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Center, Hamilton, Ontario, Canada
    J Infect Dis 206:167-77. 2012
    ..1(+) cell-depleted wild-type mice than in that from control mice. Our data suggest that NK cells significantly augment pulmonary inflammation, contributing to the pathogenesis of influenza infection...
  34. ncbi request reprint Chronic exposure to innocuous antigen in sensitized mice leads to suppressed airway eosinophilia that is reversed by granulocyte macrophage colony-stimulating factor
    Filip K Swirski
    Department of Pathology and Molecular Medicine, Division of Respiratory Diseases and Allergy and Center for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    J Immunol 169:3499-506. 2002
    ..This study shows that exposure to innocuous Ag alone does not lead to persistent eosinophilic airway inflammation, but rather to abrogated eosinophilia. This suppression can be reversed by GM-CSF...
  35. ncbi request reprint Management of food-induced anaphylaxis: unsolved challenges
    Katherine Arias
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Curr Clin Pharmacol 4:113-25. 2009
    ..This will require education of ED personnel, patient empowerment as well as effective multilateral communication among patients, emergency and family physicians, allergists and specialized volunteer organizations...
  36. doi request reprint Influenza infection leads to increased susceptibility to subsequent bacterial superinfection by impairing NK cell responses in the lung
    Cherrie Lee Small
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
    J Immunol 184:2048-56. 2010
    ..aureus phagocytosis by alveolar macrophages. Together, our study identifies the weakened NK cell response in the lung to be a novel critical mechanism for flu-mediated susceptibility to bacterial superinfection...
  37. ncbi request reprint On the generation of allergic airway diseases: from GM-CSF to Kyoto
    Stacey A Ritz
    Dept of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, HSC 4H21, 1200 Main Street West, Ontario, Hamilton, Canada
    Trends Immunol 23:396-402. 2002
    ....
  38. ncbi request reprint Impact of intranasal budesonide on immune inflammatory responses and epithelial remodeling in chronic upper airway inflammation
    Claudio Mastruzzo
    Department of Internal and Specialistic Medicine, Section of Respiratory Diseases and Section of Infectious Diseases, University of Catania, Catania, Italy
    J Allergy Clin Immunol 112:37-44. 2003
    ..Histologic and immunohistologic features of nasal polyps (NP) are similar to those observed in asthma, thus suggesting a similar immunopathology...
  39. ncbi request reprint Induction of vascular remodeling in the lung by chronic house dust mite exposure
    Kristina Rydell-Törmänen
    Department of Experimental Medical Science, Division of Vascular and Airway Research, BMC D12, S 22184 Lund, Sweden
    Am J Respir Cell Mol Biol 39:61-7. 2008
    ..We conclude that respiratory HDME exposure induces airway remodeling and pulmonary vascular remodeling, and, in accordance with airway remodeling, some components of these structural changes may be irreversible...
  40. ncbi request reprint Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodeling
    Jill R Johnson
    Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts, USA
    Am J Respir Crit Care Med 169:378-85. 2004
    ..Finally, these responses were studied for up to 9 weeks after cessation of HDM exposure. We observed that whereas airway inflammation resolved fully, the remodeling changes did not resolve and airway hyperreactivity resolved only partly...
  41. ncbi request reprint Lung fibroblast clones from normal and fibrotic subjects differ in hyaluronan and decorin production and rate of proliferation
    Gunilla Westergren-Thorsson
    Department of Cell and Molecular Biology, C13, BMC, Lund University, S 221 84 Lund, Sweden
    Int J Biochem Cell Biol 36:1573-84. 2004
    ..We suggest that different fibroblast clones accumulate in the lung, and that specific cell populations of high decorin producing fibroblasts may exist which are crucial in the pathogenesis of fibrosis...
  42. ncbi request reprint The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses
    Woong Kyung Suh
    Advanced Medical Discovery Institute, Ontario Cancer Institute, and Department of Medical Biophysics, University of Toronto, 620 University Avenue, Toronto, Ontario M5G 2C1, Canada
    Nat Immunol 4:899-906. 2003
    ..Thus, B7-H3 is a negative regulator that preferentially affects T(H)1 responses...