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Genomes and Genes | Manel JordanaSummaryAffiliation: McMaster University Country: Canada Publications
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Publications
Transforming growth factor-beta regulates house dust mite-induced allergic airway inflammation but not airway remodelingRamzi Fattouh
Department of Pathology and Molecular Medicine, Head, Division of Respiratory Diseases and Allergy, MDCL 4013, McMaster University, 1200 Main Street West, Hamilton, ON, Canada
Am J Respir Crit Care Med 177:593-603. 2008..Transforming growth factor (TGF)-beta is a powerful regulator of both the tissue repair and inflammatory responses, and numerous experimental and clinical studies suggest that it may play an integral role in the pathogenesis of asthma...
Divergent immune responses to house dust mite lead to distinct structural-functional phenotypesJill R Johnson
Department of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
Am J Physiol Lung Cell Mol Physiol 293:L730-9. 2007..These data show that distinct structural-functional phenotypes associated with chronic airway inflammation are strictly dependent on the nature of the immune-inflammatory response...- B7RP-1 is not required for the generation of Th2 responses in a model of allergic airway inflammation but is essential for the induction of inhalation toleranceBeata U Gajewska
Department of Pathology and Molecular Medicine, and Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
J Immunol 174:3000-5. 2005..In summary, our results demonstrate that in a model of mucosal allergic sensitization, the ICOS-B7RP-1 pathway is redundant for the generation of Th2 responses but essential for the induction of inhalation tolerance... - Th2 differentiation in distinct lymph nodes influences the site of mucosal Th2 immune-inflammatory responsesDavid Alvarez
Department of Pathology and Molecular Medicine, Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
J Immunol 179:3287-96. 2007..These data suggest that the site of initial Th2 differentiation and differential homing molecule expression restricts Th2 immune-inflammatory responses to mucosal, but not cutaneous, tissues... - Inhalation tolerance is induced selectively in thoracic lymph nodes but executed pervasively at distant mucosal and nonmucosal tissuesDavid Alvarez
Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, Master University, Hamilton, Ontario, Canada
J Immunol 176:2568-80. 2006..These data indicate that while inhalation tolerance is selectively induced in local thoracic LNs, its tolerogenic activity resides systemically and leads to pervasive immune tolerance in distant mucosal and nonmucosal sites... - Mainstream cigarette smoke exposure attenuates airway immune inflammatory responses to surrogate and common environmental allergens in mice, despite evidence of increased systemic sensitizationClinton S Robbins
Department of Pathology, Center for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
J Immunol 175:2834-42. 2005..MTS, therefore, plays a disparate role in the development of allergic responses, inducing a heightened state of allergen-specific sensitization, but dampening local immune inflammatory processes in the lung... - Effect of GM-CSF on immune, inflammatory, and clinical responses to ragweed in a novel mouse model of mucosal sensitizationElizabeth C Cates
Department of Pathology and Molecular Medicine and the Centre for Gene Therapeutics, Division of Respiratory Diseases and Allergy, McMaster University, Hamilton, Ontario, Canada
J Allergy Clin Immunol 111:1076-86. 2003..2. CONCLUSION: GM-CSF plays an important role in the generation of allergic immune-inflammatory responses to ragweed... - House dust mite facilitates ovalbumin-specific allergic sensitization and airway inflammationRamzi Fattouh
Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
Am J Respir Crit Care Med 172:314-21. 2005..CONCLUSION: Our data demonstrate the potential of a potent allergen such as HDM to establish a lung microenvironment that fosters the development of allergic sensitization to otherwise weak or innocuous antigens, such as OVA... - Cigarette smoke differentially affects eosinophilia and remodeling in a model of house dust mite asthmaFernando M Botelho
Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, 1200 Main Street West, Hamilton, ON, L8N 3Z5 Canada
Am J Respir Cell Mol Biol 45:753-60. 2011..Our findings demonstrate that cigarette smoke affects eosinophil migration without affecting airway resistance or modifying Th2 cell adaptive immunity in a murine model of HDM-induced asthma... - Impact of CD40 ligand, B cells, and mast cells in peanut-induced anaphylactic responsesJiangfeng Sun
Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
J Immunol 179:6696-703. 2007.... - Cutaneous antigen priming via gene gun leads to skin-selective Th2 immune-inflammatory responsesDavid Alvarez
Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
J Immunol 174:1664-74. 2005..These data indicate that Ag exposure to the skin leads to Th2 differentiation within skin-draining lymph nodes and subsequent Th2 immunity that is selectively manifested in the skin... - Intranasal exposure of mice to house dust mite elicits allergic airway inflammation via a GM-CSF-mediated mechanismElizabeth C Cates
Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, Division of Respiratory Diseases and Allergy, McMaster University, 1200 Main Street, Hamilton, Ontario, Canada L8S 3Z5
J Immunol 173:6384-92. 2004..Thus, intranasal delivery of HDM results in Th2 sensitization and airway eosinophilic inflammation that appear to be mediated, at least in part, by endogenous GM-CSF production... - Eosinophils are dispensable for allergic remodeling and immunity in a model of house dust mite-induced airway diseaseRamzi Fattouh
Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
Am J Respir Crit Care Med 183:179-88. 2011..However, direct evidence in support of this notion is limited and often controversial... - Transient corticosteroid treatment permanently amplifies the Th2 response in a murine model of asthmaRyan E Wiley
Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
J Immunol 172:4995-5005. 2004.... - Evaluation of inducible costimulator/B7-related protein-1 as a therapeutic target in a murine model of allergic airway inflammationRyan E Wiley
Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
Am J Respir Cell Mol Biol 28:722-30. 2003..This study provides in vivo evidence of an exacerbated long-term immune-inflammatory response following acute ICOS blockade, and suggests that ICOS costimulation is functionally redundant in established allergic disease... - Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactionsKatherine Arias
Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
J Allergy Clin Immunol 124:307-14, 314.e1-2. 2009..Fatality registries place peanut as the most common culprit of fatal and near-fatal reactions in North America. Because prophylaxis and treatment have advanced little in recent years, it is imperative to evaluate novel therapies... - Acute, but not resolved, influenza A infection enhances susceptibility to house dust mite-induced allergic diseaseAmal A Al-Garawi
Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
J Immunol 182:3095-104. 2009..Thus, the proinflammatory environment established during an acute influenza A infection enhances Th2-polarized immunity to a low dose of HDM and precipitates marked lung dysfunction... - Modeling responses to respiratory house dust mite exposureElizabeth C Cates
Department of Pathology and Molecular Medicine, Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
Contrib Microbiol 14:42-67. 2007..Here, we will discuss this issue, along with giving critical thought to the use of experimental models... - Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in miceKatherine Arias
Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
J Allergy Clin Immunol 127:1552-61.e1. 2011..Food-induced anaphylaxis is often a severe allergic reaction characterized by multiorgan dysfunction and a potentially fatal outcome... - Shifting of immune responsiveness to house dust mite by influenza A infection: genomic insightsAmal Al-Garawi
Division of Respiratory Diseases and Allergy, Center for Gene Therapeutics, McMaster University, Hamilton, Ontario L8S 4K1, Canada
J Immunol 188:832-43. 2012..We propose that influenza A infection primes the lung environment in such a way as to lower the threshold of allergen responsiveness, thus facilitating the emergence of a clinically significant allergic phenotype... - Combined budesonide/formoterol therapy in conjunction with allergen avoidance ameliorates house dust mite-induced airway remodeling and dysfunctionJill R Johnson
Department of Pathology and Molecular Medicine, Michael G DeGroote Centre for Learning and Discovery, McMaster University, 1200 Main St West, Hamilton, Ontario, Canada
Am J Physiol Lung Cell Mol Physiol 295:L780-8. 2008.... 
In vivo-to-in silico iterations to investigate aeroallergen-host interactionsAlba Llop-Guevara
Department of Pathology and Molecular Medicine, Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
PLoS ONE 3:e2426. 2008....- IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitizationDerek K Chu
Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada
J Allergy Clin Immunol 131:187-200.e1-8. 2013..The epithelium-associated cytokines thymic stromal lymphopoietin (TSLP), IL-25, and IL-33 are suggested to be important for the initiation of these responses... - Differential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammationJake K Nikota
1Medical Sciences Graduate Program, McMaster University, Hamilton, ON, Canada
Respir Res 12:39. 2011.... - GM-CSF and dendritic cells in allergic airway inflammation: basic mechanisms and prospects for therapeutic interventionBeata U Gajewska
Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
Curr Drug Targets Inflamm Allergy 2:279-92. 2003..Understanding these interactions may, therefore, afford insight into prospective therapeutic interventions to circumvent, and even reverse the allergic diathesis... - TGF-beta, eosinophils and IL-13 in allergic airway remodeling: a critical appraisal with therapeutic considerationsRamzi Fattouh
Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics and Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
Inflamm Allergy Drug Targets 7:224-36. 2008.... - Interleukin-13-dependent expression of matrix metalloproteinase-12 is required for the development of airway eosinophilia in miceMahmoud A Pouladi
McMaster University, Department of Pathology and Molecular Medicine, Health Sciences Centre, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada
Am J Respir Cell Mol Biol 30:84-90. 2004..Using interleukin-13 KO mice, we demonstrated that expression of MMP-12 is interleukin-13-dependent. Collectively, our data indicate a novel function for MMP-12 in the process of airway eosinophil accumulation... - A mouse model of airway disease: oncostatin M-induced pulmonary eosinophilia, goblet cell hyperplasia, and airway hyperresponsiveness are STAT6 dependent, and interstitial pulmonary fibrosis is STAT6 independentDominik K Fritz
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
J Immunol 186:1107-18. 2011.... - Critical role of natural killer cells in lung immunopathology during influenza infection in miceMohamed F Abdul-Careem
McMaster Immunology Research Centre and Institute for Infectious Diseases Research, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Center, Hamilton, Ontario, Canada
J Infect Dis 206:167-77. 2012..1(+) cell-depleted wild-type mice than in that from control mice. Our data suggest that NK cells significantly augment pulmonary inflammation, contributing to the pathogenesis of influenza infection... - Chronic exposure to innocuous antigen in sensitized mice leads to suppressed airway eosinophilia that is reversed by granulocyte macrophage colony-stimulating factorFilip K Swirski
Department of Pathology and Molecular Medicine, Division of Respiratory Diseases and Allergy and Center for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
J Immunol 169:3499-506. 2002..This study shows that exposure to innocuous Ag alone does not lead to persistent eosinophilic airway inflammation, but rather to abrogated eosinophilia. This suppression can be reversed by GM-CSF... - Granulocyte macrophage colony-stimulating factor-driven respiratory mucosal sensitization induces Th2 differentiation and function independently of interleukin-4Stacey A Ritz
Department of Pathology and Molecular Medicine and Centre for Gene Therapeutics, Division of Respiratory Diseases and Allergy, McMaster University, Hamilton, Ontario, Canada
Am J Respir Cell Mol Biol 27:428-35. 2002..We conclude that IL-4 is not required for the generation of Th2-polarized responses in the presence of GM-CSF... - Management of food-induced anaphylaxis: unsolved challengesKatherine Arias
Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
Curr Clin Pharmacol 4:113-25. 2009..This will require education of ED personnel, patient empowerment as well as effective multilateral communication among patients, emergency and family physicians, allergists and specialized volunteer organizations... - Influenza infection leads to increased susceptibility to subsequent bacterial superinfection by impairing NK cell responses in the lungCherrie Lee Small
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
J Immunol 184:2048-56. 2010..aureus phagocytosis by alveolar macrophages. Together, our study identifies the weakened NK cell response in the lung to be a novel critical mechanism for flu-mediated susceptibility to bacterial superinfection... - On the generation of allergic airway diseases: from GM-CSF to KyotoStacey A Ritz
Dept of Pathology and Molecular Medicine and Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, HSC-4H21, 1200 Main Street West, Ontario, Hamilton, Canada
Trends Immunol 23:396-402. 2002.... - Impact of intranasal budesonide on immune inflammatory responses and epithelial remodeling in chronic upper airway inflammationClaudio Mastruzzo
Department of Internal and Specialistic Medicine, Section of Respiratory Diseases and Section of Infectious Diseases, University of Catania, Catania, Italy
J Allergy Clin Immunol 112:37-44. 2003..Furthermore, intranasal budesonide promoted epithelial remodeling. We hypothesize that these immunoregulatory and remodeling effects elicited by steroids might be, at least in part, mediated by the induction of TGF-beta... - Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodelingJill R Johnson
Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts, USA
Am J Respir Crit Care Med 169:378-85. 2004..Finally, these responses were studied for up to 9 weeks after cessation of HDM exposure. We observed that whereas airway inflammation resolved fully, the remodeling changes did not resolve and airway hyperreactivity resolved only partly... - Induction of vascular remodeling in the lung by chronic house dust mite exposureKristina Rydell-Törmänen
Department of Experimental Medical Science, Division of Vascular and Airway Research, BMC D12, S 22184 Lund, Sweden
Am J Respir Cell Mol Biol 39:61-7. 2008..We conclude that respiratory HDME exposure induces airway remodeling and pulmonary vascular remodeling, and, in accordance with airway remodeling, some components of these structural changes may be irreversible... - The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responsesWoong Kyung Suh
Advanced Medical Discovery Institute, Ontario Cancer Institute, and Department of Medical Biophysics, University of Toronto, 620 University Avenue, Toronto, Ontario M5G 2C1, Canada
Nat Immunol 4:899-906. 2003..Thus, B7-H3 is a negative regulator that preferentially affects T(H)1 responses... - Lung fibroblast clones from normal and fibrotic subjects differ in hyaluronan and decorin production and rate of proliferationGunilla Westergren-Thorsson
Department of Cell and Molecular Biology, C13, BMC, Lund University, S 221 84 Lund, Sweden
Int J Biochem Cell Biol 36:1573-84. 2004..We suggest that different fibroblast clones accumulate in the lung, and that specific cell populations of high decorin producing fibroblasts may exist which are crucial in the pathogenesis of fibrosis... - Generation and characterization of B7-H4/B7S1/B7x-deficient miceWoong Kyung Suh
Campbell Family Institute for Breast Cancer Research, 620 University Ave, Suite 706, Toronto, Ontario, Canada
Mol Cell Biol 26:6403-11. 2006..These results suggest that B7-H4 is one of multiple negative cosignaling molecules that collectively provide a fine-tuning mechanism for T-cell-mediated immune responses...