R H Hunt

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. doi request reprint Evolving issues in the management of reflux disease?
    Yuhong Yuan
    Department of Medicine, Division of Gastroenterology, McMaster University Health Science Centre, Hamilton, Canada
    Curr Opin Gastroenterol 25:342-51. 2009
  2. doi request reprint Acid-NSAID/aspirin interaction in peptic ulcer disease
    Richard H Hunt
    Farncombe Family Digestive Health Research Institute, Division of Gastroenterology, McMaster University Health Science Centre, Hamilton, Ont, Canada
    Dig Dis 29:465-8. 2011
  3. pmc Novel approaches to inhibition of gastric acid secretion
    George Sachs
    Department of Physiology and Medicine, David Geffen School of Medicine, University of California at Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Curr Gastroenterol Rep 12:437-47. 2010
  4. doi request reprint Predictable prolonged suppression of gastric acidity with a novel proton pump inhibitor, AGN 201904-Z
    R H Hunt
    Division of Gastroenterology, McMaster University and Hamilton Health Science Centre, Hamilton, ON, Canada
    Aliment Pharmacol Ther 28:187-99. 2008
  5. ncbi request reprint Complementary studies of the gastrointestinal safety of the cyclo-oxygenase-2-selective inhibitor etoricoxib
    R H Hunt
    Division of Gastroenterology, McMaster University Medical Center, Hamilton, Ontario, Canada
    Aliment Pharmacol Ther 17:201-10. 2003
  6. doi request reprint The pharmacodynamics and pharmacokinetics of S-tenatoprazole-Na 30 mg, 60 mg and 90 mg vs. esomeprazole 40 mg in healthy male subjects
    R H Hunt
    Farncombe Family Digestive Disease Research Institute, Division of Gastroenterology, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    Aliment Pharmacol Ther 31:648-57. 2010
  7. ncbi request reprint Helicobacter pylori twenty years on
    Richard H Hunt
    McMaster University Medical Centre, Hamilton, Ontario L8N 3Z5, Canada
    Can J Gastroenterol 17:7B. 2003
  8. ncbi request reprint Motion--Cyclo-oxygenase-2 selective nonsteroidal anti-inflammatory drugs are as safe as placebo for the stomach: arguments for the motion
    Richard H Hunt
    Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Room 4W8A, Hamilton, Ontario L8N 3Z5, Canada
    Can J Gastroenterol 17:339-41. 2003
  9. ncbi request reprint Review article: the unmet needs in delayed-release proton-pump inhibitor therapy in 2005
    R H Hunt
    Division of Gastroenterology, McMaster University Health Science Centre, Hamilton, ON, Canada
    Aliment Pharmacol Ther 22:10-9. 2005
  10. ncbi request reprint The evolving epidemiology of Helicobacter pylori infection and gastric cancer
    Jia Qing Huang
    Department of Medicine, Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Ontario L8N 3Z5, Canada
    Can J Gastroenterol 17:18B-20B. 2003

Detail Information

Publications78

  1. doi request reprint Evolving issues in the management of reflux disease?
    Yuhong Yuan
    Department of Medicine, Division of Gastroenterology, McMaster University Health Science Centre, Hamilton, Canada
    Curr Opin Gastroenterol 25:342-51. 2009
    ..Gastroesophageal reflux disease (GERD) is a common chronic disorder often successfully treated, although there are several evolving issues in management. We reviewed the issues related to unmet needs over the past 12 months...
  2. doi request reprint Acid-NSAID/aspirin interaction in peptic ulcer disease
    Richard H Hunt
    Farncombe Family Digestive Health Research Institute, Division of Gastroenterology, McMaster University Health Science Centre, Hamilton, Ont, Canada
    Dig Dis 29:465-8. 2011
    ..PPI co-therapy is still recommended in patients receiving dual antiplatelet treatment, although conflicting results have been reported about adverse drug interactions between PPIs and clopidogrel...
  3. pmc Novel approaches to inhibition of gastric acid secretion
    George Sachs
    Department of Physiology and Medicine, David Geffen School of Medicine, University of California at Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Curr Gastroenterol Rep 12:437-47. 2010
    ..pylori eradication...
  4. doi request reprint Predictable prolonged suppression of gastric acidity with a novel proton pump inhibitor, AGN 201904-Z
    R H Hunt
    Division of Gastroenterology, McMaster University and Hamilton Health Science Centre, Hamilton, ON, Canada
    Aliment Pharmacol Ther 28:187-99. 2008
    ..AGN 201904-Z is a new, slowly absorbed, acid-stable pro-proton pump inhibitor (pro-PPI) rapidly converted to omeprazole in the systemic circulation giving a prolonged residence time...
  5. ncbi request reprint Complementary studies of the gastrointestinal safety of the cyclo-oxygenase-2-selective inhibitor etoricoxib
    R H Hunt
    Division of Gastroenterology, McMaster University Medical Center, Hamilton, Ontario, Canada
    Aliment Pharmacol Ther 17:201-10. 2003
    ..Cyclo-oxygenase-2-selective non-steroidal anti-inflammatory drugs are intended to preserve cyclo-oxygenase-1-mediated gastroprotection and platelet function, whilst inhibiting cyclo-oxygenase-2-mediated inflammation...
  6. doi request reprint The pharmacodynamics and pharmacokinetics of S-tenatoprazole-Na 30 mg, 60 mg and 90 mg vs. esomeprazole 40 mg in healthy male subjects
    R H Hunt
    Farncombe Family Digestive Disease Research Institute, Division of Gastroenterology, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    Aliment Pharmacol Ther 31:648-57. 2010
    ..Racemic tenatoprazole 40 mg/day provides more prolonged acid suppression than esomeprazole 40 mg/day...
  7. ncbi request reprint Helicobacter pylori twenty years on
    Richard H Hunt
    McMaster University Medical Centre, Hamilton, Ontario L8N 3Z5, Canada
    Can J Gastroenterol 17:7B. 2003
  8. ncbi request reprint Motion--Cyclo-oxygenase-2 selective nonsteroidal anti-inflammatory drugs are as safe as placebo for the stomach: arguments for the motion
    Richard H Hunt
    Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Room 4W8A, Hamilton, Ontario L8N 3Z5, Canada
    Can J Gastroenterol 17:339-41. 2003
    ..Coxibs are an important addition to the pharmacotherapy of inflammatory disease...
  9. ncbi request reprint Review article: the unmet needs in delayed-release proton-pump inhibitor therapy in 2005
    R H Hunt
    Division of Gastroenterology, McMaster University Health Science Centre, Hamilton, ON, Canada
    Aliment Pharmacol Ther 22:10-9. 2005
    ....
  10. ncbi request reprint The evolving epidemiology of Helicobacter pylori infection and gastric cancer
    Jia Qing Huang
    Department of Medicine, Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Ontario L8N 3Z5, Canada
    Can J Gastroenterol 17:18B-20B. 2003
    ..Therefore, searching for cagA-positive strains of H pylori may help identify populations at a greater risk for developing gastric cancer...
  11. ncbi request reprint Review article: should NSAID/low-dose aspirin takers be tested routinely for H. pylori infection and treated if positive? Implications for primary risk of ulcer and ulcer relapse after initial healing
    R H Hunt
    McMaster University Medical Centre, Hamilton, Ontario, Canada
    Aliment Pharmacol Ther 19:9-16. 2004
    ..The success of eradication therapy should always be confirmed, because of the risk of ulcer recurrence and bleeding in H. pylori-infected patients who require anti-inflammatory treatments...
  12. pmc Approach to managing musculoskeletal pain: acetaminophen, cyclooxygenase-2 inhibitors, or traditional NSAIDs?
    Richard H Hunt
    Division of Gastroenterology at McMaster University in Hamilton, Ont
    Can Fam Physician 53:1177-84. 2007
    ..To provide family physicians and pharmacists with practical, evidence- and expertise-based guidance on choosing the safest approach to using analgesics to manage patients with musculoskeletal pain...
  13. ncbi request reprint Evolving concepts in the pathophysiology of functional gastrointestinal disorder
    Richard H Hunt
    Division of Gastroenterology, Room 4W8A, McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    J Clin Gastroenterol 35:S2-6. 2002
    ....
  14. pmc pH, healing rate and symptom relief in acid-related diseases
    J Q Huang
    Department of Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Yale J Biol Med 69:159-74. 1996
    ..Combinations of an antisecretory drug with one or more antimicrobial agents accelerate healing of peptic ulcers...
  15. pmc Effect of purified lipopolysaccharides from strains of Helicobacter pylori and Helicobacter felis on acid secretion in mouse gastric glands in vitro
    I T Padol
    Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario, Canada
    Infect Immun 69:3891-6. 2001
    ..pylori LPS did not have any direct antisecretory properties. It can be speculated that the acid stimulatory properties of LPS from H. pylori SS1 may contribute to the gastric damage observed in the mouse model of H. pylori infection...
  16. ncbi request reprint Gastric acid secretory response in Helicobacter pylori-positive patients with duodenal ulcer disease
    K Jacobson
    Department of Medicine, McMaster University Medical Centre, Hamilton, Canada
    Can J Gastroenterol 15:29-39. 2001
    ....
  17. ncbi request reprint Pharmacological and pharmacodynamic essentials of H(2)-receptor antagonists and proton pump inhibitors for the practising physician
    J Q Huang
    Division of Gastroenterology, Department of Medicine, McMaster University Medical Center, Hamilton, Ontario, Canada
    Best Pract Res Clin Gastroenterol 15:355-70. 2001
    ....
  18. pmc pH, healing rate, and symptom relief in patients with GERD
    J Q Huang
    Department of Medicine, McMaster University Medical Center, Hamilton, Ontario, Canada
    Yale J Biol Med 72:181-94. 1999
    ....
  19. ncbi request reprint Cost effectiveness in Canada of a multidrug prepackaged regimen (Hp-PAC)+ for Helicobacter pylori eradication
    K Agro
    Centre for Evaluation of Medicines, St Joseph's Hospital, Hamilton, Ontario, Canada
    Pharmacoeconomics 19:831-43. 2001
    ..More data on the clinical and statistical differences in H. pylori eradication with Hp-PAC and PPI-CM would be useful. This analysis does not in clude the possible advantage of Hp-PAC in terms of compliance and antibacterial resistance...
  20. ncbi request reprint A randomized controlled trial to assess alendronate-associated injury of the upper gastrointestinal tract
    J K Marshall
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Aliment Pharmacol Ther 14:1451-7. 2000
    ..Aminobisphosphonates are recommended for postmenopausal osteoporosis but have been associated with injury to the upper gastrointestinal tract...
  21. ncbi request reprint Effects of chronic NSAIDs on gastric mucosal injury related to mucosal prostanoids, and plasma drug concentrations in human volunteers
    K D Rainsford
    Department of Biomedical Sciences, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada
    Agents Actions 39:C21-3. 1993
    ..Fundic PGE2 was reduced by IND, NAP and PIR; APZ had no effects. Thus, mucosal damage relates to effects on prostanoid production in the antrum but not in the fundus...
  22. ncbi request reprint Will eradication of Helicobacter pylori infection influence the risk of gastric cancer?
    Richard H Hunt
    McMaster University Medical Center, Hamilton, Ontario, Canada
    Am J Med 117:86S-91S. 2004
    ....
  23. pmc Eradication of Helicobacter pylori infection in the management of patients with dyspepsia and non-ulcer dyspepsia
    J Q Huang
    Department of Medicine, McMaster University Medical Center, Hamilton, Ontario, Canada
    Yale J Biol Med 71:125-33. 1998
    ..H. pylori eradication therapy is cost-effective in H. pylori-infected dyspeptic patients although this benefit may take a long time to accrue, especially in younger patients...
  24. ncbi request reprint Implications of antibiotic resistance in the management of Helicobacter pylori infection: Canadian Helicobacter Study Group
    R H Hunt
    Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada
    Can J Gastroenterol 14:862-8. 2000
    ..However, it is important to understand the mechanisms of the development of resistant strains to manage patients with treatment failure better...
  25. ncbi request reprint Canadian Helicobacter Study Group Consensus Conference on the Approach to Helicobacter pylori Infection in Children and Adolescents
    P Sherman
    Division of Gastrotenterology and Nutrition, Department of Pediatrics, University of Toronto, Ontario, Canada
    Can J Gastroenterol 13:553-9. 1999
    ..It is appropriate to limit diagnosis and treatment to children and adolescents in whom H pylori has been identified during endoscopic investigation...
  26. ncbi request reprint The gastrointestinal safety of the COX-2 selective inhibitor etoricoxib assessed by both endoscopy and analysis of upper gastrointestinal events
    Richard H Hunt
    Division of Gastroenterology, McMaster University Medical Center, Hamilton, Ontario, Canada
    Am J Gastroenterol 98:1725-33. 2003
    ....
  27. ncbi request reprint Peptic ulcer disease today
    Yuhong Yuan
    McMaster University, Health Science Centre, Hamilton, ON, Canada
    Nat Clin Pract Gastroenterol Hepatol 3:80-9. 2006
    ..Understanding the pathophysiology and best treatment strategies for non-NSAID, non-H. pylori-associated peptic ulcers presents a challenge...
  28. doi request reprint Is there an increased risk of GERD after Helicobacter pylori eradication?: a meta-analysis
    Mohammad Yaghoobi
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Am J Gastroenterol 105:1007-13; quiz 1006, 1014. 2010
    ..Some studies suggest that eradication of Helicobacter pylori (Hp) might increase the risk of gastroesophageal reflux disease (GERD) in a portion of patients. We aimed to conduct a meta-analysis to investigate this...
  29. pmc Inflammation, acid and ulcers
    M J Muller
    Intestinal Disease Research Programme, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Yale J Biol Med 67:135-44. 1994
    ..These studies are reviewed in light of our current knowledge of the physiological control of gastric acid secretion...
  30. ncbi request reprint Ranitidine bismuth citrate
    N Chiba
    Surrey GI Clinic/Research, Guelph, Ontario, Canada
    Can J Gastroenterol 15:389-98. 2001
    ..RBC, used alone or in combination with other antibiotics, appears to be a safe and effective drug for the treatment of H pylori infection. Bismuth levels do not appear to rise to toxic levels...
  31. doi request reprint Meta-analysis: incidence of endoscopic gastric and duodenal ulcers in placebo arms of randomized placebo-controlled NSAID trials
    Y H Yuan
    Farncombe Family Digestive Health Research Institute, Division of Gastroenterology, Department of Medicine, McMaster University Health Science Centre, Hamilton, Canada
    Aliment Pharmacol Ther 30:197-209. 2009
    ..The safety of NSAIDs is often evaluated by comparison with placebo in clinical trials...
  32. ncbi request reprint Acid suppression in healthy subjects following lansoprazole or pantoprazole
    J Q Huang
    McMaster University, Hamilton, Ont, Canada
    Aliment Pharmacol Ther 16:425-33. 2002
    ..To compare the effect of lansoprazole, 30 mg once daily, with that of pantoprazole, 40 mg once daily, for the inhibition of gastric acid secretion...
  33. ncbi request reprint Review article: should we kill or should we save Helicobacter pylori?
    R H Hunt
    Division of Gastroenterology, Department of Medicine, McMaster University Medical Center, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada
    Aliment Pharmacol Ther 15:51-9. 2001
    ..pylori infection is a serious pathogen albeit in a minority of those infected. It remains for carefully designed prospective studies, rather than hypothesis to make changes in the current consensus position...
  34. ncbi request reprint Global gastrointestinal safety profile of etoricoxib and lumiracoxib
    Yuhong Yuan
    Division of Gastroenterology, Department of Medicine, McMaster University Health Science Centre, Hamilton, Canada
    Curr Pharm Des 13:2237-47. 2007
    ....
  35. ncbi request reprint Has education about Helicobacter pylori infection been effective? Worldwide survey of primary care physicians
    Jiaqing Huang
    Department of Gastroenterology, McMaster University Medical Centre, Hamilton, Ontario, Canada
    J Gastroenterol Hepatol 18:512-20. 2003
    ..Confusion exists among physicians about the management of Helicobacter pylori (H. pylori) infection. We aimed to survey primary care physicians' (PCP) knowledge and management of H. pylori-related diseases...
  36. doi request reprint Altered physiology of acid secretion in depression-prone Flinders rats results in exacerbated NSAID and stress-induced gastric damage
    I T Padol
    Farncombe Family Digestive Health Research Institute, Division of Gastroenterology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Neurogastroenterol Motil 24:154-63, e89. 2012
    ..A link between depression and peptic ulcers has long been established; however, there is a lack of data from animal models...
  37. ncbi request reprint Obscure gastrointestinal bleeding: an approach to management
    J K Marshall
    Department of Medicine, and Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario, Canada
    Can J Gastroenterol 14:111-8. 2000
    ..A stepwise management algorithm that progresses from the history and physical examination to surgical exploration is offered to facilitate early and efficient diagnosis...
  38. pmc Alteration of H2 receptor sensitivity in duodenal ulcer patients after maintenance treatment with an H2 receptor antagonist
    D B Jones
    Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Gut 29:890-3. 1988
    ..This might be explained on the basis of an increase in the number of H2 receptors ('up-regulation')...
  39. ncbi request reprint A Canadian physician survey of dyspepsia management
    N Chiba
    Surrey GI Clinic, Guelph, Ontario
    Can J Gastroenterol 12:83-90. 1998
    ..To determine the management of patients with new onset dyspepsia by Canadian family physicians...
  40. ncbi request reprint Canadian Consensus Conference on the management of gastroesophageal reflux disease in adults - update 2004
    David Armstrong
    Division of Gastroenterology, McMaster University, Hamilton
    Can J Gastroenterol 19:15-35. 2005
    ..Since the last Canadian Consensus Conference in 1996, GERD management has evolved substantially...
  41. ncbi request reprint Recommendations for the appropriate use of anti-inflammatory drugs in the era of the coxibs: defining the role of gastroprotective agents
    Richard H Hunt
    Division of Gastroenterology, Department of Medicine, McMaster University Medical Centre, Hamilton, Ontario
    Can J Gastroenterol 16:231-40. 2002
    ..Patients at high risk require a GPA in addition to a coxib...
  42. pmc Practice Audit in Gastroenterology (PAGE) program: a novel approach to continuing professional development
    David Armstrong
    Division of Gastroenterology, McMaster University, Hamilton, Ontario
    Can J Gastroenterol 20:405-10. 2006
    ..This qualitative study assessed the use of personal digital assistants to facilitate data collection and review...
  43. ncbi request reprint Risks and benefits of Helicobacter pylori eradication: current status
    Richard H Hunt
    Department of Medicine, McMaster University, Hamilton, Ontario
    Can J Gastroenterol 16:57-62. 2002
    ..The management guidelines designed specifically in Canada should, therefore, continue to be applied, with H pylori diagnosed and treated in appropriately selected patients...
  44. ncbi request reprint Helicobacter pylori public health implications
    Paul Moayyedi
    Department of Medicine, Gastroenterology Division, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Helicobacter 9:67-72. 2004
    ..The medical community should be consistent and if we are instituting other population screening programmes without randomized controlled trial evidence then H. pylori testing and treatment should also be considered...
  45. doi request reprint International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding
    Alan N Barkun
    Division of Gastroenterology, Montreal General Hospital Site, McGill University Health Centre, Montreal, Quebec, Canada
    Ann Intern Med 152:101-13. 2010
    ..A multidisciplinary group of 34 experts from 15 countries developed this update and expansion of the recommendations on the management of acute nonvariceal upper gastrointestinal bleeding (UGIB) from 2003...
  46. doi request reprint The gain in quality-adjusted life months by switching to esomeprazole in those with continued reflux symptoms in primary care: EncomPASS--a cluster-randomized trial
    Paul Moayyedi
    Division of Gastroenterology, Department of Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Am J Gastroenterol 105:2341-6. 2010
    ..We expressed the data in terms of cost per quality-adjusted life months (QALM), as this was a 4-week trial...
  47. pmc Access to specialist gastroenterology care in Canada: the Practice Audit in Gastroenterology (PAGE) Wait Times Program
    D Armstrong
    McMaster Health Sciences Centre, Hamilton, Ontario, Canada
    Can J Gastroenterol 22:155-60. 2008
    ..Wait times for gastroenterology consultation and procedures have not been studied, although digestive diseases pose a greater economic burden in Canada than cancer or heart disease...
  48. pmc Effect of Th1 cytokines on acid secretion in pharmacologically characterised mouse gastric glands
    I T Padol
    Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario, Canada
    Gut 53:1075-81. 2004
    ..The presence of inflammatory cells and their products, in close proximity to parietal cells, questions the extent of the effect of cytokines on acid secretion...
  49. ncbi request reprint Helicobacter pylori: from art to a science
    R H Hunt
    Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Ontario, Canada
    J Gastroenterol Hepatol 13:21-8. 1998
    ..These achieve amongst the highest eradication rates and have also been shown to be cost effective. This paper reviews these recent advances and addresses areas of clinical interest and future directions...
  50. pmc Progress with proton pump inhibition
    N J Bell
    Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Yale J Biol Med 65:649-57;discussion 689-92. 1992
    ..This effect may result from enhancement of antibiotic bioavailability and optimizing host defense mechanisms...
  51. ncbi request reprint Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease: a meta-analysis
    Jia Qing Huang
    Division of Gastroenterology, Department of Medicine, McMaster University Medical Center, 1200 Main Street West, Room 4W8, Ontario L8N 3Z8, Hamilton, Canada
    Lancet 359:14-22. 2002
    ..The relation between H pylori infection and use of non-steroidal anti-inflammatory drugs (NSAIDs) in the pathogenesis of peptic-ulcer disease is controversial. We undertook a meta-analysis to address this issue...
  52. ncbi request reprint The effect of CYP2C19 polymorphisms on H. pylori eradication rate in dual and triple first-line PPI therapies: a meta-analysis
    Sara Padol
    Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada
    Am J Gastroenterol 101:1467-75. 2006
    ..We conducted a meta-analysis to investigate the evidence relating CYP2C19 to first-line H. pylori eradication rates...
  53. ncbi request reprint Meta-analysis of the relationship between cagA seropositivity and gastric cancer
    Jia Qing Huang
    Department of Gastroenterology, McMaster University Medical Center, Hamilton, Ontario, Canada
    Gastroenterology 125:1636-44. 2003
    ..pylori infection alone are conflicting. The aim of this study was to estimate the magnitude of the risk for gastric cancer associated with cagA seropositivity and to identify any sources of heterogeneity between studies...
  54. ncbi request reprint Etiology of dyspepsia: implications for empirical therapy
    Richard H Hunt
    Division of Gastroenterology, Department of Medicine, McMaster University, Hamilton, Canada
    Can J Gastroenterol 16:635-41. 2002
    ..Hence, a 'symptom and treat' acid-suppression trial with proton pump inhibitors, and a 'test and treat' strategy for H pylori are two acceptable empirical therapies for patients with univestigated dyspepsia...
  55. ncbi request reprint Controversial issues in gastroesophageal reflux disease
    R H Hunt
    Division of Gastroenterology, McMaster University, Hamilton, Ontario
    Can J Gastroenterol 11:87B-90B. 1997
    ..This paper reviews these topics and addresses the controversial issues...
  56. ncbi request reprint Establishment of T-Helper-2 immune response based gerbil model of enteric infection
    M Sagar
    Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario, Canada
    Scand J Gastroenterol 39:668-73. 2004
    ....
  57. doi request reprint Helicobacter pylori infection and Barrett's esophagus: a systematic review and meta-analysis
    Changcheng Wang
    Division of Gastroenterology, Department of Medicine, McMaster University Health Science Centre, Hamilton, Ontario, Canada
    Am J Gastroenterol 104:492-500; quiz 491, 501. 2009
    ..Helicobacter pylori (H. pylori) infection plays an etiological role in gastric carcinogenesis, but any possible role in BE is uncertain. We aimed to explore the possible relationship between H. pylori infection and BE by meta-analysis...
  58. ncbi request reprint The association between Helicobacter pylori infection and early gastric cancer: a meta-analysis
    Changcheng Wang
    Division of Gastroenterology, Health Science Centre, McMaster University, Hamilton, Ontario, Canada
    Am J Gastroenterol 102:1789-98. 2007
    ..pylori infection in early gastric cancer (EGC) has been performed. We aimed to review systematically the relationship between H. pylori infection and EGC, and different types of EGC...
  59. doi request reprint Endoscopic clipping for acute nonvariceal upper-GI bleeding: a meta-analysis and critical appraisal of randomized controlled trials
    Yuhong Yuan
    Division of Gastroenterology, McMaster University Health Science Centre, Hamilton, Ontario, Canada
    Gastrointest Endosc 68:339-51. 2008
    ..Acute nonvariceal upper-GI bleeding (NVUGIB) is common, with a high rate of recurrent bleeding and substantial mortality rate. Endoscopic clipping has the theoretical advantage of minimizing tissue injury and is increasingly used...
  60. ncbi request reprint Review article: olestra and its gastrointestinal safety
    A B Thomson
    Division of Gastroenterology, University of Alberta, Edmonton, Canada
    Aliment Pharmacol Ther 12:1185-200. 1998
    ....
  61. ncbi request reprint Effects of misoprostol on the pharmacokinetics of indomethacin in human volunteers
    K D Rainsford
    Department of Biomedical Sciences, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada
    Clin Pharmacol Ther 51:415-21. 1992
    ..Thus misoprostol does not interfere with the absorption of indomethacin despite the known inhibitory effects of this protaglandin analog on acid secretion...
  62. doi request reprint Impact of oesophagitis classification in evaluating healing of erosive oesophagitis after therapy with proton pump inhibitors: a pooled analysis
    Mohammad Yaghoobi
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Eur J Gastroenterol Hepatol 22:583-90. 2010
    ..The aim of this study was to review systematically the literature to compare the healing rates of erosive oesophagitis with PPIs in clinical trials assessed by the HD, SM, or LA classifications...
  63. doi request reprint Precise role of acid in non-erosive reflux disease
    Changcheng Wang
    Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Ont, Canada
    Digestion 78:31-41. 2008
    ..Analysis such as analysis of the area under the H(+) activity time curve is one alternative approach for evaluating acid secretion. The precise role of acid in NERD needs further clarification...
  64. ncbi request reprint Evolving concepts in functional gastrointestinal disorders: promising directions for novel pharmaceutical treatments
    Richard H Hunt
    Department of Medicine, Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Best Pract Res Clin Gastroenterol 16:869-83. 2002
    ..It is likely that there will be multiple therapeutic options based on the spectrum of abnormalities capable of causing the spectrum of symptoms of functional gastrointestinal disorders in any individual patient...
  65. ncbi request reprint Effect on intragastric pH of a PPI with a prolonged plasma half-life: comparison between tenatoprazole and esomeprazole on the duration of acid suppression in healthy male volunteers
    Richard H Hunt
    Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Am J Gastroenterol 100:1949-56. 2005
    ..To compare the inhibitory effect of a novel proton pump inhibitor (PPI), tenatoprazole 40 mg once daily, with esomeprazole 40 mg once daily on intragastric acidity...
  66. ncbi request reprint Host-specific differences in the physiology of acid secretion related to prostaglandins may play a role in gastric inflammation and injury
    Ireneusz T Padol
    Div of Gastroenterology, McMaster Univ, Health Sciences Centre, Rm 4W8A, 1200 Main St West, Hamilton, ON, Canada L8N 3Z5
    Am J Physiol Gastrointest Liver Physiol 288:G1110-7. 2005
    ..We propose that the lack of antisecretory effect of PGE(2) observed in C57BL/6 mice could reflect the extent of Helicobacter-induced inflammation and status of acid secretion in response to anti-inflammatory drugs...
  67. ncbi request reprint Doctor-patient interaction for irritable bowel syndrome in primary care: a systematic perspective
    Surinder K Dhaliwal
    McMaster University Medical Center, Hamilton, Canada
    Eur J Gastroenterol Hepatol 16:1161-6. 2004
    ..However, IBS is poorly understood by patients. We aimed to explore how a diagnosis of IBS affects the interaction between patients and their physicians...
  68. pmc Prevalence, impact and attitudes toward lower gastrointestinal dysmotility and sensory symptoms, and their treatment in Canada: A descriptive study
    Richard H Hunt
    McMaster University Medical Center, Hamilton, Canada
    Can J Gastroenterol 21:31-7. 2007
    ..To investigate the impact of lower gastrointestinal (GI) symptoms in the general Canadian population, and to explore patient satisfaction with traditional therapies and the level of patient interest in new treatments. patients and..
  69. ncbi request reprint Time course and pattern of blood loss with ibuprofen treatment in healthy subjects
    Barry Bowen
    McMaster University Health Sciences Centre, Hamilton, Ontario, Canada L8N 3Z5
    Clin Gastroenterol Hepatol 3:1075-82. 2005
    ..We aimed to assess the pattern and extent of fecal blood loss (FBL) with ibuprofen, which is considered to have a favorable gastrointestinal safety profile...
  70. doi request reprint Systematic reviews: the good, the bad, and the ugly
    Yuhong Yuan
    Division of Gastroenterology, Department of Medicine, McMaster University Health Science Centre, Hamilton, Ontario, Canada
    Am J Gastroenterol 104:1086-92. 2009
    ..This paper aims to assist in the reading of a systematic review...
  71. ncbi request reprint Minimizing postcolonoscopy abdominal pain by using CO(2) insufflation: a prospective, randomized, double blind, controlled trial evaluating a new commercially available CO(2) delivery system
    Katica Sumanac
    McMaster University Medical Center, Hamilton, Ontario, Canada
    Gastrointest Endosc 56:190-4. 2002
    ..A commercially available CO(2) delivery system has only recently become available. The effects of CO(2) and air insufflation on residual bowel gas and postprocedure pain were compared...
  72. doi request reprint Medical management of gastroesophageal reflux disease
    Changcheng Wang
    Division of Gastroenterology, Department of Medicine, McMaster University Health Science Centre, 1200 Main Street West, HSC 4W8A, Hamilton, Ontario L8N 3Z5, Canada
    Gastroenterol Clin North Am 37:879-99, ix. 2008
    ..An alternative approach to controlling transient lower esophageal sphincter relaxations, such as the GABA-B agonists, deserves further study...
  73. ncbi request reprint 14 day endoscopy study comparing risedronate and alendronate in postmenopausal women stratified by Helicobacter pylori status
    Alan B R Thomson
    University of Alberta, Edmonton, Canada
    J Rheumatol 29:1965-74. 2002
    ..This study compared the incidence of gastric ulcers after treatment with risedronate, a pyridinyl bisphosphonate, or alendronate, a primary amino bisphosphonate, in healthy postmenopausal women stratified by Helicobacter pylori status...
  74. ncbi request reprint Whistler summary: "the slow rate of rapid progress"
    Richard H Hunt
    J Clin Gastroenterol 41:539-45. 2007
  75. ncbi request reprint Do patients with non-ulcer dyspepsia respond differently to Helicobacter pylori eradication treatments from those with peptic ulcer disease? A systematic review
    Jia Qing Huang
    Department of Medicine, Faculty of Medicine, University of Hong Kong, Hong Kong, China
    World J Gastroenterol 11:2726-32. 2005
    ..To review the evidence for any difference in H pylori eradication rates between PUD and NUD patients...
  76. ncbi request reprint Selective serotonin reuptake inhibitors and risk of upper GI bleeding: confusion or confounding?
    Yuhong Yuan
    Division of Gastroenterology, Department of Medicine, Health Science Centre, McMaster University, Hamilton, Ontario, Canada
    Am J Med 119:719-27. 2006
    ..To what extent the use of SSRIs increases the risk of gastrointestinal bleeding is unclear...
  77. ncbi request reprint GERD evaluation: time for a new paradigm?
    Irvin M Modlin
    Yale University School of Medicine, New Haven, CT 06520, USA
    J Clin Gastroenterol 41:237-41. 2007
    ..We propose that accurate symptom delineation complemented with endoscopy performed in selected groups of patients will become the mainstay in diagnosis of GERD and the assessment of therapy efficacy...
  78. ncbi request reprint Acetaminophen and aminotransferase elevations
    Yuhong Yuan
    JAMA 296:2798; author reply 2798-9. 2006