A C Holloway

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint Influence of dichlorodiphenylchloroethylene on vascular endothelial growth factor and insulin-like growth factor in human and rat ovarian cells
    A C Holloway
    Department of Obstetrics and Gynaecology, Reproductive Biology Division, McMaster University, Health Sciences Centre, Hamilton, ON, Canada
    Reprod Toxicol 24:359-64. 2007
  2. doi request reprint Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids
    James McNulty
    Department of Chemistry, McMaster University, 1280 Main Street West, Hamilton, Ont, Canada L8S 4M1
    Bioorg Med Chem Lett 19:3233-7. 2009
  3. pmc Fetal and neonatal nicotine exposure in Wistar rats causes progressive pancreatic mitochondrial damage and beta cell dysfunction
    Jennifer E Bruin
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 3:e3371. 2008
  4. pmc Evaluation of the association between maternal smoking, childhood obesity, and metabolic disorders: a national toxicology program workshop review
    Mamta Behl
    Kelly Government Solutions, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 121:170-80. 2013
  5. ncbi request reprint Fetal and neonatal exposure to nicotine disrupts ovarian function and fertility in adult female rats
    A C Holloway
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada
    Endocrine 30:213-6. 2006
  6. ncbi request reprint Transgenerational effects of fetal and neonatal exposure to nicotine
    Alison C Holloway
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, RM HSC 3N52, 1200 Main Street West, Hamilton, ON, Canada
    Endocrine 31:254-9. 2007
  7. ncbi request reprint Rosiglitazone prevents diabetes by increasing beta-cell mass in an animal model of type 2 diabetes characterized by reduced beta-cell mass at birth
    A C Holloway
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Diabetes Obes Metab 10:763-71. 2008
  8. ncbi request reprint Fetal and neonatal exposure to nicotine in Wistar rats results in increased beta cell apoptosis at birth and postnatal endocrine and metabolic changes associated with type 2 diabetes
    A C Holloway
    Department of Obstetrics and Gynecology, McMaster University, Rm 3N52 HSC 1200 Main Street W, Hamilton, ON, Canada, L8N 3Z5
    Diabetologia 48:2661-6. 2005
  9. doi request reprint Effect of combining rosiglitazone with either metformin or insulin on β-cell mass and function in an animal model of Type 2 diabetes characterized by reduced β-cell mass at birth
    Alison C Holloway
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    J Diabetes 3:74-81. 2011
  10. ncbi request reprint Urocortin: a mechanism for the sustained activation of the HPA axis in the late-gestation ovine fetus?
    Alison C Holloway
    Department of Physiology, Canadian Institute for Health Research Groups in Fetal and Neonatal Health and Development, University of Toronto, Toronto, Ontario M55 1A8, Canada
    Am J Physiol Endocrinol Metab 283:E165-71. 2002

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Influence of dichlorodiphenylchloroethylene on vascular endothelial growth factor and insulin-like growth factor in human and rat ovarian cells
    A C Holloway
    Department of Obstetrics and Gynaecology, Reproductive Biology Division, McMaster University, Health Sciences Centre, Hamilton, ON, Canada
    Reprod Toxicol 24:359-64. 2007
    ..This alteration in expression of growth factors may lead to altered ovarian function as seen in polycystic ovaries and impaired fertility...
  2. doi request reprint Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids
    James McNulty
    Department of Chemistry, McMaster University, 1280 Main Street West, Hamilton, Ont, Canada L8S 4M1
    Bioorg Med Chem Lett 19:3233-7. 2009
    ..Important pharmacological features uncovered include the lack of CYP3A4 inhibitory activity seen for galanthamine and the selective activity that is seen with narciclasine over pancratistatin...
  3. pmc Fetal and neonatal nicotine exposure in Wistar rats causes progressive pancreatic mitochondrial damage and beta cell dysfunction
    Jennifer E Bruin
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 3:e3371. 2008
    ..These results clearly indicate that further investigation into the safety of NRT use during pregnancy is warranted...
  4. pmc Evaluation of the association between maternal smoking, childhood obesity, and metabolic disorders: a national toxicology program workshop review
    Mamta Behl
    Kelly Government Solutions, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 121:170-80. 2013
    ....
  5. ncbi request reprint Fetal and neonatal exposure to nicotine disrupts ovarian function and fertility in adult female rats
    A C Holloway
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada
    Endocrine 30:213-6. 2006
    ..We conclude that fetal and neonatal exposure to nicotine results in delayed ovarian dysfunction in adult female offspring...
  6. ncbi request reprint Transgenerational effects of fetal and neonatal exposure to nicotine
    Alison C Holloway
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, RM HSC 3N52, 1200 Main Street West, Hamilton, ON, Canada
    Endocrine 31:254-9. 2007
    ..The offspring of nicotine-exposed mothers also had elevated blood pressure. These data demonstrate that adverse effects of fetal and neonatal exposure to nicotine can influence aspects of metabolic risk in subsequent generations...
  7. ncbi request reprint Rosiglitazone prevents diabetes by increasing beta-cell mass in an animal model of type 2 diabetes characterized by reduced beta-cell mass at birth
    A C Holloway
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Diabetes Obes Metab 10:763-71. 2008
    ..The effect of this drug on both glucose levels and beta-cell mass was studied in a rat model of diabetes, characterized by reduced beta-cell mass at birth with normoglycaemia, and progression to dysglycaemia with age...
  8. ncbi request reprint Fetal and neonatal exposure to nicotine in Wistar rats results in increased beta cell apoptosis at birth and postnatal endocrine and metabolic changes associated with type 2 diabetes
    A C Holloway
    Department of Obstetrics and Gynecology, McMaster University, Rm 3N52 HSC 1200 Main Street W, Hamilton, ON, Canada, L8N 3Z5
    Diabetologia 48:2661-6. 2005
    ..This study examines the effect of fetal and neonatal exposure to nicotine, the major addictive component of cigarettes, on postnatal growth, adiposity and glucose homeostasis...
  9. doi request reprint Effect of combining rosiglitazone with either metformin or insulin on β-cell mass and function in an animal model of Type 2 diabetes characterized by reduced β-cell mass at birth
    Alison C Holloway
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    J Diabetes 3:74-81. 2011
    ..These effects may be mediated through changes in β-cell mass. In the present study, the effect of combining rosiglitazone with metformin and/or insulin on β-cell mass and glucose levels was examined in a rat model of Type 2 diabetes...
  10. ncbi request reprint Urocortin: a mechanism for the sustained activation of the HPA axis in the late-gestation ovine fetus?
    Alison C Holloway
    Department of Physiology, Canadian Institute for Health Research Groups in Fetal and Neonatal Health and Development, University of Toronto, Toronto, Ontario M55 1A8, Canada
    Am J Physiol Endocrinol Metab 283:E165-71. 2002
    ..Regulation of urocortin by cortisol suggests a mechanism to override negative feedback and sustain feedforward of fetal hypothalamic-pituitary-adrenal function, leading to birth...
  11. ncbi request reprint Effects of labor on pituitary expression of proopiomelanocortin, prohormone convertase (PC)-1, PC-2, and glucocorticoid receptor mRNA in fetal sheep
    A C Holloway
    MRC Group in Fetal and Neonatal Health and Development, Toronto, Ontario, Canada
    Endocrine 13:17-23. 2000
    ..Furthermore, the negative feedback effects of cortisol on pituitary POMC synthesis and/or ACTH release during active parturition may be lessened by downregulation of anterior pituitary GR...
  12. doi request reprint Effects of rosiglitazone on ovarian function and fertility in animals with reduced fertility following fetal and neonatal exposure to nicotine
    J J Petrik
    Department of Biomedical Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Endocrine 36:281-90. 2009
    ..Rosiglitazone may be an important treatment option for PCOS and the present study provides a potential mechanism by which rosiglitazone may have beneficial effects on fertility in these patients...
  13. ncbi request reprint Glucocorticoid regulation of human and ovine parturition: the relationship between fetal hypothalamic-pituitary-adrenal axis activation and intrauterine prostaglandin production
    W L Whittle
    MRC Group in Fetal and Neonatal Health and Development, University of Toronto, Toronto, Ontario, Canada M5A 1A8
    Biol Reprod 64:1019-32. 2001
    ....
  14. ncbi request reprint Prostaglandin production at the onset of ovine parturition is regulated by both estrogen-independent and estrogen-dependent pathways
    W L Whittle
    Department of Physiology, University of Toronto, Ontario, Canada
    Endocrinology 141:3783-91. 2000
    ....
  15. ncbi request reprint Expression of prostaglandin I(2) synthase, but not prostaglandin E synthase, changes in myometrium of women at term pregnancy
    D Giannoulias
    Canadian Institutes of Health Research in Human Development, Department of Physiology, University of Toronto, 1 King s College Circle, Medical Sciences Building Room 3344, Toronto, Ontario, Canada M5S 1A8
    J Clin Endocrinol Metab 87:5274-82. 2002
    ..The lack of change in PGES indicates that alterations at other points along the pathway of arachidonic acid metabolism may be of greater importance in affecting local changes in PGE(2)...
  16. ncbi request reprint Fetal and neonatal nicotine exposure and postnatal glucose homeostasis: identifying critical windows of exposure
    Jennifer E Bruin
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, RM HSC 3N52, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    J Endocrinol 194:171-8. 2007
    ..This model of type 2 diabetes requires that nicotine exposure occurs both in utero and during lactation...
  17. ncbi request reprint Effects of cortisol and estradiol on pituitary expression of proopiomelanocortin, prohormone convertase-1, prohormone convertase-2, and glucocorticoid receptor mRNA in fetal sheep
    A C Holloway
    Department of Physiology, University of Toronto, Ontario, Canada
    Endocrine 14:343-8. 2001
    ..We suggest that in the late-gestation sheep fetus, cortisol and estradiol have opposite effects on pituitary POMC and GR mRNA expression, and interact to regulate these key components of the fetal HPA axis...
  18. doi request reprint Chronic nicotine blunts hypoxic sensitivity in perinatal rat adrenal chromaffin cells via upregulation of KATP channels: role of alpha7 nicotinic acetylcholine receptor and hypoxia-inducible factor-2alpha
    Josef Buttigieg
    Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    J Neurosci 29:7137-47. 2009
    ..The therapeutic potential of K(ATP) channel blockers was validated in experiments in which hypoxia-induced neonatal mortality in nicotine-exposed pups was significantly reduced after pretreatment with glibenclamide...
  19. pmc Long-term consequences of fetal and neonatal nicotine exposure: a critical review
    Jennifer E Bruin
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Toxicol Sci 116:364-74. 2010
    ..This review will examine the long-term effects of fetal and neonatal nicotine exposure on postnatal health...
  20. ncbi request reprint The effects of in utero and lactational exposure to chloroform on postnatal growth and glucose tolerance in male Wistar rats
    Gareth E Lim
    Reproductive Biology Division, Department of Obstetrics and Gynecology, RM HSC 3N52, McMaster University, Hamilton, Ontario, Canada, L8N 3Z5
    Endocrine 25:223-8. 2004
    ..Although fetal and neonatal exposure to chloroform did not elicit physiological changes associated with the onset of type 2 diabetes, there were physiological changes resulting in impaired postnatal growth...
  21. doi request reprint Maternal nicotine exposure increases oxidative stress in the offspring
    Jennifer E Bruin
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    Free Radic Biol Med 44:1919-25. 2008
    ..These data suggest that beta-cell apoptosis in the fetal and neonatal pancreas may be the result of a direct effect of nicotine via its receptor and that this effect may be mediated through increased oxidative stress...
  22. doi request reprint Effect of nicotine exposure during pregnancy and lactation on maternal, fetal, and postnatal rat IGF-II profile
    Andree Gruslin
    Division Maternal Fetal Medicine, Department OBS GYN and Newborn Care, The Ottawa Hospital University of Ottawa, Ontario, Canada
    Reprod Sci 16:875-82. 2009
    ..Our postnatal findings of suppressed IGF-II may help explain some of the long-term health complications seen in individuals exposed to smoking in utero...
  23. doi request reprint Interleukin-15 treatment improves glucose homeostasis and insulin sensitivity in obese mice
    N G Barra
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics and Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada
    Diabetes Obes Metab 14:190-3. 2012
    ..These results show that IL-15 may be a novel therapeutic target for the treatment of obesity and its associated abnormal glucose regulation...
  24. ncbi request reprint Ontogeny and regulation of ovine placental prostaglandin E2 synthase
    R L Martin
    Canadian Institutes for Health Research Groups in Fetal and Neonatal Health and Development, Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Biol Reprod 67:868-73. 2002
    ..These results suggest that PGES is not coregulated with PGHS-2 in the sheep placenta at term. The progressive increase in PGES, however, likely contributes to the rise in circulating PGE2 in the fetus in late pregnancy...
  25. doi request reprint Structure-activity studies on seco-pancratistatin analogs: potent inhibitors of human cytochrome P450 3A4
    James McNulty
    Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, Ont, Canada L8S 4M1
    Bioorg Med Chem Lett 19:5607-12. 2009
    ..These studies identify potential roadblocks and will guide the further development of a viable selective clinical pancratistatin derivative...
  26. ncbi request reprint Regulation of oxygen sensitivity in adrenal chromaffin cells
    Colin A Nurse
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Ann N Y Acad Sci 1177:132-9. 2009
    ..Thus, nicotinic AChR activation may contribute to the suppression of hypoxic sensitivity in AMC, and this pathway could provide the basis for the loss of hypoxia tolerance in the offspring of smoking mothers...
  27. doi request reprint Isolation of flavonoids from the heartwood and resin of Prunus avium and some preliminary biological investigations
    James McNulty
    Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4M1
    Phytochemistry 70:2040-6. 2009
    ..The defensive role of these natural plant flavonoids as antifungal phytoalexins and phytoanticipins is discussed...
  28. doi request reprint Potent and selective inhibition of human cytochrome P450 3A4 by seco-pancratistatin structural analogs
    James McNulty
    Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, Ont, Canada L8S 4M1
    Bioorg Med Chem Lett 20:2335-9. 2010
    ....
  29. ncbi request reprint Cytochrome P450 3A4 inhibitory activity studies within the lycorine series of alkaloids
    James McNulty
    Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4M1, Canada
    Nat Prod Commun 5:1195-200. 2010
    ....
  30. doi request reprint Effects of fetal and neonatal exposure to nicotine on blood pressure and perivascular adipose tissue function in adult life
    Yu Jing Gao
    Smooth Muscle Research Program, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Eur J Pharmacol 590:264-8. 2008
    ..Alterations in perivascular adipose tissue composition and modulatory function are some of the mechanisms associated with this blood pressure increase...
  31. doi request reprint Human cytochrome P450 liability studies of trans-dihydronarciclasine: a readily available, potent, and selective cancer cell growth inhibitor
    James McNulty
    Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada, L8S 4M1
    J Nat Prod 74:106-8. 2011
    ..This study elevates the status of trans-dihydronarciclasine (5) as a highly privileged, readily available molecule, with potent and selective anticancer activity...
  32. doi request reprint Effects in rats of maternal exposure to raspberry leaf and its constituents on the activity of cytochrome p450 enzymes in the offspring
    Emilija Makaji
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Int J Toxicol 30:216-24. 2011
    ..Kaempferol and quercetin had a similar effect to RRL. These results suggest that maternal consumption of either RRL or some of its constituents leads to long-term alterations of CYP activity in female offspring...
  33. ncbi request reprint Synergistic effects between FSH and 1,1-dichloro-2,2-bis(P-chlorophenyl)ethylene (P,P'-DDE) on human granulosa cell aromatase activity
    Edward V Younglai
    Department of Obstetrics and Gynaecology, Reproductive Biology Division, McMaster University, Health Sciences Centre, Hamilton, Ontario, Canada
    Hum Reprod 19:1089-93. 2004
    ..The objective of this study was to investigate the interaction between FSH and ppDDE on aromatase activity in primary cultures of human granulosa cells...
  34. ncbi request reprint Prenatal exposure to nicotine causes postnatal obesity and altered perivascular adipose tissue function
    Yu Jing Gao
    Department of Anaesthesia HSC 2U3, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Obes Res 13:687-92. 2005
    ..The aim of this study was to examine the effect of fetal and neonatal exposure to nicotine, the major addictive component of cigarette smoke, on postnatal adiposity and blood vessel function...
  35. doi request reprint Developmental and lactational exposure to environmentally relevant concentrations of dieldrin does not alter pregnancy outcome and mammary gland morphology in BALB/c mice
    Warren G Foster
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, HSC 3N52D, 1200 Main Street West, Hamilton, Ontario, Canada
    Environ Res 108:21-7. 2008
    ..Treatments had no effect on fertility parameters in dams or mammary gland morphology at sexual maturity. Developmental exposure to dieldrin has no effect on mammary gland development in aged BALB/c mice...
  36. doi request reprint Using a drug to structure its release matrix and release profile
    Michael A Brook
    Department of Chemistry, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada
    Int J Pharm 358:121-7. 2008
    ..The relationship between excipients, silicone morphology, and release profile is examined...
  37. ncbi request reprint Dioxin-like activity and maternal thyroid hormone levels in second trimester maternal serum
    Warren G Foster
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Health Sciences Centre, Hamilton, Ontario, Canada
    Am J Obstet Gynecol 193:1900-7. 2005
    ..Therefore, the objective of this study was to quantify the overall dioxin-like activity in maternal serum and determine the association between dioxin-like activity and thyroid hormone levels...
  38. doi request reprint Increased pancreatic beta-cell apoptosis following fetal and neonatal exposure to nicotine is mediated via the mitochondria
    Jennifer E Bruin
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Toxicol Sci 103:362-70. 2008
    ..Taken together, these data suggest that beta-cell apoptosis following developmental nicotine exposure is mediated via the mitochondria...
  39. ncbi request reprint Environmental and occupational factors affecting fertility and IVF success
    Edward V Younglai
    Department of Obstetrics and Gynaecology, Reproductive Biology Division, McMaster University, Health Sciences Centre, Hamilton, Ontario, Canada
    Hum Reprod Update 11:43-57. 2005
    ..We consider both the male and female partners since it is essentially their combined contributions of gametes which may be affected by chemicals, which lead to successful outcomes...
  40. ncbi request reprint Benzo-[a]-pyrene increases invasion in MDA-MB-231 breast cancer cells via increased COX-II expression and prostaglandin E2 (PGE2) output
    M E Miller
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Clin Exp Metastasis 22:149-56. 2005
    ..Moreover, these results suggest a potential role for the AhR signalling pathway in breast cancer invasion...
  41. ncbi request reprint Chronic nicotine in utero selectively suppresses hypoxic sensitivity in neonatal rat adrenal chromaffin cells
    Josef Buttigieg
    Department of Biology, McMaster University, 1280 Main St West, Hamilton, Ontario, Canada L8S 4K1
    FASEB J 22:1317-26. 2008
    ....
  42. ncbi request reprint Atrazine-induced changes in aromatase activity in estrogen sensitive target tissues
    A C Holloway
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    J Appl Toxicol 28:260-70. 2008
    ..Therefore it is concluded that microm concentrations of ATR can increase aromatase activity of human granulosa cells but not ESC and this effect is not elicited at the enzyme level...
  43. ncbi request reprint DDE-induced changes in aromatase activity in endometrial stromal cells in culture
    Alison C Holloway
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Endocrine 27:45-50. 2005
    ..Our data demonstrate that p,p'-DDE treatment can increase aromatase activity in ESC in culture...
  44. ncbi request reprint Sidestream smoking is equally as damaging as mainstream smoking on IVF outcomes
    Michael S Neal
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Hum Reprod 20:2531-5. 2005
    ..Our objective was to measure the effects of CS on the fertility of mainstream (MS) or sidestream (SS) smoke-exposed women compared to their non-smoking (NS) counterparts...
  45. ncbi request reprint Follicle growth is inhibited by benzo-[a]-pyrene, at concentrations representative of human exposure, in an isolated rat follicle culture assay
    Michael S Neal
    Centre for Reproductive Care, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Hum Reprod 22:961-7. 2007
    ..Using a novel isolated rat follicle culture assay, we tested the hypothesis that benzo-[a]-pyrene (B[a]P), a constituent of cigarette smoke, can inhibit follicle growth...
  46. ncbi request reprint The effects of dietary phytoestrogens on aromatase activity in human endometrial stromal cells
    Katie M Edmunds
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario
    Reprod Nutr Dev 45:709-20. 2005
    ..Taken together, our data suggest that genistein can increase aromatase activity in ESC likely via increased enzyme expression...
  47. ncbi request reprint Effect of environmental contaminants on Beta cell function
    Emilija Makaji
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Int J Toxicol 30:410-8. 2011
    ..These data suggest that long-term BPA exposure may be detrimental to beta cell function and ultimately be an important contributor to the etiology of T2D...
  48. pmc Fetal and neonatal exposure to nicotine disrupts postnatal lung development in rats: role of VEGF and its receptors
    Maria A Petre
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Int J Toxicol 30:244-52. 2011
    ..The current study suggests that perinatal exposure to nicotine alters lung development, an effect which may be mediated via decreased vascular endothelial growth factor (VEGF) signaling...
  49. doi request reprint Effects of cytochrome P450 inhibitors on the biotransformation of fluorogenic substrates by adult male rat liver microsomes and cDNA-expressed rat cytochrome P450 isoforms
    Emilija Makaji
    Department of Obstetrics and Gynecology, McMaster University, Ontario, Canada
    Toxicol Sci 113:293-304. 2010
    ..Our results also demonstrate the inappropriateness of extrapolating inhibitory data between conventional and fluorogenic CYP substrates...
  50. ncbi request reprint Periconceptional undernutrition in sheep accelerates maturation of the fetal hypothalamic-pituitary-adrenal axis in late gestation
    Frank H Bloomfield
    Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Endocrinology 145:4278-85. 2004
    ....
  51. ncbi request reprint Granulosa cell aromatase activity in women undergoing IVF: a comparison of good and poor responders
    Michael S Neal
    Centre for Reproductive Care, Hamilton Health Sciences, Hamilton ON, Canada
    J Obstet Gynaecol Can 30:138-42. 2008
    ..We wished to investigate the aromatase activity (AA) of granulosa cells (GCs) in women undergoing ovarian follicular stimulation for in vitro fertilization (IVF)...