Research Topics
| Nancy M HeddleSummaryAffiliation: McMaster University Country: Canada Publications
| Collaborators
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Detail Information
Publications
Utilization of platelet transfusions in the intensive care unit: indications, transfusion triggers, and platelet count responsesDonald M Arnold
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Transfusion 46:1286-91. 2006..A description of current platelet (PLT) transfusion practice in the intensive care unit (ICU) is needed...- The research questionNancy M Heddle
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Transfusion 47:15-7. 2007 
The effect of blood storage duration on in-hospital mortality: a randomized controlled pilot feasibility trialNancy M Heddle
Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
Transfusion 52:1203-12. 2012..The objective was to determine feasibility of a comparative effectiveness trial to evaluate duration of storage of blood before transfusion on in-hospital mortality...- Challenges and opportunities to prevent transfusion errors: a Qualitative Evaluation for Safer Transfusion (QUEST)Nancy M Heddle
Department of Medicine and McMaster Transfusion Research Program, McMaster University, and Canadian Blood Services, Hamilton, Ontario, Canada
Transfusion 52:1687-95. 2012..A qualitative study was undertaken to understand this process from the perspective of those who administer blood products and to identify concerns and suggestions to improve safety... 
Do expert assessments converge? An exploratory case study of evaluating and managing a blood supply riskJohn Eyles
School of Geography and Earth Sciences, McMaster University, 1280 Main St West, Hamilton, Ontario, Canada
BMC Public Health 11:666. 2011..It also describes the context of publicly funded blood transfusion in Canada and the withdrawal event that is the basis of this study...- A randomized controlled trial comparing the frequency of acute reactions to plasma-removed platelets and prestorage WBC-reduced plateletsNancy M Heddle
Department of Pathology, McMaster University, Hamilton, Ontario, Canada
Transfusion 42:556-66. 2002..This study evaluates the effectiveness of plasma removal and two methods of prestorage WBC reduction for preventing acute reactions to platelets... - In vitro evaluation of prestorage pooled leukoreduced whole blood-derived platelets stored for up to 7 daysN M Heddle
Department of Medicine, McMaster University, Canadian Blood Services, Hamilton, Ontario, Canada
Transfusion 45:904-10. 2005..The in vitro quality of pre-storage pooled PLTs stored for up to 7 days was assessed... - A descriptive analysis of international transfusion practice and bleeding outcomes in patients with acute leukemiaNancy M Heddle
Department of Medicine, McMaster University, Canadian Blood Services, Hamilton, Ontario, Canada, and the Transfusion and Transplant Immunology Center IRCCS, Maggiore Hospital, Milan, Italy
Transfusion 46:903-11. 2006..The purpose of this study was to provide a descriptive summary of data from PLT studies conducted in four countries and exploratory analyses to determine the relationship between bleeding and PLT count... - Evidence-based decision making in transfusion medicineN M Heddle
McMaster Transfusion Research Program, McMaster Uiversity, Canadian Blood Services, Hamilton, Ontario, Canada
Vox Sang 91:214-20. 2006.... - Comparing the efficacy and safety of apheresis and whole blood-derived platelet transfusions: a systematic reviewNancy M Heddle
The Department of Medicine and the Department of Molecular Medicine and Pathology, McMaster University, Hamilton, Ontario, Canada
Transfusion 48:1447-58. 2008.... - A policy informing qualitative study to improve the process of blood product recalls and withdrawalsNancy M Heddle
Departments of Medicine and the School of Geography, and Earth Science, McMaster University, Hamilton, Ontario, Canada
Transfusion 48:2585-95. 2008..With the use of qualitative techniques and a modified grounded theory approach, the current process was mapped, issues were identified, and recommendations to improve the system were developed... - A randomized controlled trial comparing standard- and low-dose strategies for transfusion of platelets (SToP) to patients with thrombocytopeniaNancy M Heddle
Department of Medicine, McMaster University, Hamilton, ON, Canada
Blood 113:1564-73. 2009..Whether this finding was due to chance or represents a real difference requires further investigation. These clinical studies are registered on (http://www.clinicaltrials.gov) as NCT00420914... - Assessing the effectiveness of whole blood-derived platelets stored as a pool: a randomized block noninferiority trialN M Heddle
Department of Medicine and Pathology and Molecular Medicine, McMaster University, and the Canadian Blood Services, Hamilton, Ontario, Canada
Transfusion 45:896-903. 2005..This study evaluated the in vivo effect of the prestorage pooling of PLTs stored for up to 5 days, by assessing the corrected count increment (CCI) 18 to 24 hours after transfusion of the product... - Factors affecting the frequency of red blood cell outdates: an approach to establish benchmarking targetsNancy M Heddle
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Transfusion 49:219-26. 2009..In this study, a provincial database of red blood cell (RBC) product inventory/disposition in hospitals was analyzed to identify factors that affected RBC outdates and to systematically establish optimal target levels for RBC outdates... - Clinical research designs: quantitative studiesNancy M Heddle
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Vox Sang 83:247-50. 2002 - Methodologic issues in the use of bleeding as an outcome in transfusion medicine studiesNancy M Heddle
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Transfusion 43:742-52. 2003.... - Adjudicating bleeding events in a platelet dose study: impact on outcome results and challengesNancy M Heddle
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Transfusion 51:2304-10. 2011..This study describes the challenges associated with adjudicating bleeding events and compares the adjudicated and bedside results for bleeding grade... - A multicenter pilot-randomized controlled trial of the feasibility of an augmented red blood cell transfusion strategy for patients treated with induction chemotherapy for acute leukemia or stem cell transplantationKathryn E Webert
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Transfusion 48:81-91. 2008..Anemia may be an important factor contributing to an increased risk of bleeding, particularly in patients with thrombocytopenia... - A pilot randomized trial of adjuvant rituximab or placebo for nonsplenectomized patients with immune thrombocytopeniaDonald M Arnold
Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
Blood 119:1356-62. 2012..No difference in the frequency of the composite outcome was observed in this pilot trial (registered at www.clinicaltrials.gov NCT00372892)... - A new tool to assess bleeding severity in patients with chemotherapy-induced thrombocytopeniaKathryn E Webert
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Transfusion 52:2466-74; quiz 2465. 2012..The aim of this study was to develop a simple, valid, and reliable measurement tool to categorize the severity of bleeding in patients with chemotherapy-induced thrombocytopenia (CIT)... - An evaluation of methods for determining reference intervals for light transmission platelet aggregation tests on samples with normal or reduced platelet countsCatherine P M Hayward
McMaster University and the Hamilton Regional Laboratory Medicine Program, Hamilton, Ontario, Canada, L8N 3Z5
Thromb Haemost 100:134-45. 2008..The derived limits for thrombocytopenic samples provide guidance for evaluating thrombocytopenic platelet function disorders, including which agonists to test, based on the sample platelet count... - In vivo recovery and survival of apheresis and whole blood-derived platelets: a paired comparison in healthy volunteersDonald M Arnold
Canadian Blood Services, Hamilton, Ontario, Canada
Transfusion 46:257-64. 2006..The reasons for this effect are not clear. These results may not apply to all apheresis and PRP methods of platelet preparation... - Platelet transfusions in children: results of a randomized, prospective, crossover trial of plasma removal and a prospective audit of WBC reductionStephen Couban
Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
Transfusion 42:753-8. 2002..The effectiveness of plasma reduction after storage and WBC reduction of platelet concentrates before storage was studied in pediatric recipients of platelet transfusions... - Duration of red cell storage before transfusion and in-hospital mortalityJohn W Eikelboom
Department of Medicine, McMaster University, Ontario, Canada
Am Heart J 159:737-743.e1. 2010..The objective of the study was to examine the association between duration of pretransfusion storage of red cells and in-hospital mortality... - Misleading hepatitis B test results due to intravenous immunoglobulin administration: implications for a clinical trial of rituximab in immune thrombocytopeniaDonald M Arnold
Department of Medicine, Michael deGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
Transfusion 50:2577-81. 2010..A high seroprevalence of anti-HBc observed among patients screened for the trial prompted this substudy to investigate for an association between anti-HBc seropositivity and exposure to intravenous immunoglobulin (IVIG)... - Transfusion premedication to prevent acute transfusion reactions: a retrospective observational study to assess current practicesJessica L Fry
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
Transfusion 50:1722-30. 2010.... - Posttransfusion platelet count increments after ABO-compatible versus ABO-incompatible platelet transfusions in noncancer patients: an observational studyKaterina Pavenski
Department of Medicine, McMaster University, and Canadian Blood Services, Hamilton, Ontario, Canada
Transfusion 50:1552-60. 2010..However, most studies to date have been small and involved hematology/oncology patients... 
A review of randomized controlled trials comparing the effectiveness of hand held computers with paper methods for data collectionShannon J Lane
Department of Medicine, McMaster University, Hamilton, Canada
BMC Med Inform Decis Mak 6:23. 2006..CONCLUSION: Handhelds are an effective alternative to paper and pencil modes of data collection; they are faster and were preferred by most users...- A study of the agreement between patient self-assessment and study personnel assessment of bleeding symptomsKathryn E Webert
McMaster University, Hamilton, Ontario, Canada
Transfusion 46:1926-33. 2006..These assessments are commonly performed by study personnel and can be time-consuming. The purpose of this study was to assess whether patients were able to reliably assess their bleeding status on a daily basis... - The risk of bleeding in thrombocytopenic patients with acute myeloid leukemiaKathryn Webert
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Haematologica 91:1530-7. 2006..Patients with acute myeloid leukemia are at risk of bleeding. The risk factors for different severities of bleeding are poorly studied... - Hypotensive transfusion reactions can occur with blood products that are leukoreduced before storageDonald M Arnold
Canadian Blood Services, Ontario, Canada
Transfusion 44:1361-6. 2004..CONCLUSION: Hypotensive reactions can occur with blood products that are LR before storage and non-LR ANH. An inherent defect in the metabolism of kinins may be a risk factor for the development of hypotensive transfusion reactions... - Combination immunosuppressant therapy for patients with chronic refractory immune thrombocytopenic purpuraDonald M Arnold
Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada
Blood 115:29-31. 2010..Severe adverse events did not occur. Combination immunosuppressant therapy can produce a rise in the platelet count that is sometimes sustained in refractory ITP patients... - A retrospective 11-year analysis of obstetric patients with idiopathic thrombocytopenic purpuraKathryn E Webert
Department of Medicine, McMaster University, Rm HSC 3N43, 1200 Main St W, Hamilton, ON, Canada L8N 3Z5
Blood 102:4306-11. 2003..6%) required treatment for hemostatic impairment. Two fetal deaths occurred. One was caused by hemorrhage. ITP in pregnancy carries a low risk, but mothers and infants may require therapy to raise their platelet counts... - Understanding the meaning of permanent deferral for blood donorsSusan Whittaker
Department of Medicine and the Department of Nursing, McMaster University, Hamilton, Ontario, Canada
Transfusion 48:64-72. 2008..The purpose of this study was to explore the permanent deferral experience from the donor's perspective... - The Canadian Transfusion Surveillance System: what is it and how can the data be used?Julie DiTomasso
Hamilton Regional Laboratory Medicine Program, Hamilton, Ontario, Canada
Transfus Apher Sci 46:329-35. 2012..Although hemovigilance data has been successfully used to improve blood safety, we must continue to explore ways to utilize such data to improve and implement safe transfusion practices... - The role of comparative effectiveness research in transfusion medicine clinical trials: proceedings of a National Heart, Lung, and Blood Institute workshopMorris A Blajchman
McMaster University, Hamilton, Ontario, Canada
Transfusion 52:1363-78. 2012.... - Developing a tracking system for coagulation factor concentrates in southern OntarioIrwin R Walker
McMaster University Medical Center, 1200 Main St West, Hamilton, Ontario, Canada, L8N 3Z5, USA
Transfusion 43:556-62. 2003..This study describes the development of a verifiable and comprehensive regional tracking system for coagulation factor concentrates... - Diagnostic utility of light transmission platelet aggregometry: results from a prospective study of individuals referred for bleeding disorder assessmentsC P M Hayward
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
J Thromb Haemost 7:676-84. 2009..Light transmission aggregometry (LTA) is commonly performed to assess individuals for bleeding disorders... - Individual and contextual determinants of blood donation frequency with a focus on clinic accessibility: a case study of Toronto, CanadaKristina Cimaroli
School of Geography and Earth Sciences, McMaster University, 1280 Main St West, Hamilton, Ontario, Canada
Health Place 18:424-33. 2012..The results indicate that higher levels of accessibility increase the probability of donor return and more frequent donations... - Designing laboratory-based research studies: is it time for a change?Richard J Cook
Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada
Transfusion 47:2336-7. 2007 - Laboratory diagnosis of immune heparin-induced thrombocytopeniaTheodore E Warkentin
Hamilton Regional Laboratory Medicine Program, Hamilton Health Sciences, Hamilton General Site, 237 Baron Street East, Hamilton, ON L8L 2X2, Canada
Curr Hematol Rep 2:148-57. 2003..quot; However, optimal diagnostic information requires that laboratory test results be interpreted in the appropriate clinical context... - Benchmarking: applications to transfusion medicineTorunn Oveland Apelseth
Department of Immunology and Transfusion Medicine, Haukeland University Hospital, Bergen, Norway
Transfus Med Rev 26:321-32. 2012..For those interested in initiating a benchmarking program, the sentinel site model may be most effective and sustainable as a starting point, although the regional model would be the ideal goal... - Geographical variations in the correlates of blood donor turnout rates: an investigation of Canadian metropolitan areasP J Saberton
School of Geography and Earth Sciences, McMaster University, Hamilton Ontario, Canada
Int J Health Geogr 8:56. 2009..Analysis of donor data will help to identify systematic patterns of donation and its correlates... - Bleeding risks associated with inheritance of the Quebec platelet disorderHeather McKay
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
Blood 104:159-65. 2004..These data illustrate that QPD is associated with increased risks of bleeding that can be modified by fibrinolytic inhibitors... - Clinical and laboratory practices in investigation of suspected transfusion-transmitted bacterial infection: a survey of Canadian hospitalsA N Traore
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Vox Sang 96:157-9. 2009..If there is no residual product in the component bag, 36% of respondents would use a segment to perform testing. Guidelines could be helpful in improving and standardizing these practices... - Methods for the analysis of bleeding outcomes in randomized trials of PLT transfusion triggersR J Cook
Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada
Transfusion 44:1135-42. 2004..The analysis strategy should be selected based on the clinical question being addressed... - Universal leukoreduction and acute transfusion reactions: putting the puzzle togetherNancy M Heddle
Transfusion 44:1-4. 2004 - Intravenous (IV) anti-D and IV immunoglobulin achieve acute platelet increases by different mechanisms: modulation of cytokine and platelet responses to IV anti-D by FcgammaRIIa and FcgammaRIIIa polymorphismsNichola Cooper
Division of Hematology Oncology, Department of Pediatrics, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, NY 10021, USA
Br J Haematol 124:511-8. 2004.... - Evidence-based clinical reporting: a need for improvementNancy M Heddle
Transfusion 42:1106-10. 2002 - Clinical research design and reporting: always room for improvement!Nancy M Heddle
Transfusion 47:2-3. 2007