Nancy M Heddle

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint The research question
    Nancy M Heddle
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 47:15-7. 2007
  2. ncbi request reprint In vitro evaluation of prestorage pooled leukoreduced whole blood-derived platelets stored for up to 7 days
    N M Heddle
    Department of Medicine, McMaster University, Canadian Blood Services, Hamilton, Ontario, Canada
    Transfusion 45:904-10. 2005
  3. ncbi request reprint Utilization of platelet transfusions in the intensive care unit: indications, transfusion triggers, and platelet count responses
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 46:1286-91. 2006
  4. doi request reprint The effect of blood storage duration on in-hospital mortality: a randomized controlled pilot feasibility trial
    Nancy M Heddle
    Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Transfusion 52:1203-12. 2012
  5. doi request reprint Challenges and opportunities to prevent transfusion errors: a Qualitative Evaluation for Safer Transfusion (QUEST)
    Nancy M Heddle
    Department of Medicine and McMaster Transfusion Research Program, McMaster University, and Canadian Blood Services, Hamilton, Ontario, Canada
    Transfusion 52:1687-95. 2012
  6. pmc Do expert assessments converge? An exploratory case study of evaluating and managing a blood supply risk
    John Eyles
    School of Geography and Earth Sciences, McMaster University, 1280 Main St West, Hamilton, Ontario, Canada
    BMC Public Health 11:666. 2011
  7. ncbi request reprint Assessing the effectiveness of whole blood-derived platelets stored as a pool: a randomized block noninferiority trial
    N M Heddle
    Department of Medicine and Pathology and Molecular Medicine, McMaster University, and the Canadian Blood Services, Hamilton, Ontario, Canada
    Transfusion 45:896-903. 2005
  8. ncbi request reprint A descriptive analysis of international transfusion practice and bleeding outcomes in patients with acute leukemia
    Nancy M Heddle
    Department of Medicine, McMaster University, Canadian Blood Services, Hamilton, Ontario, Canada, and the Transfusion and Transplant Immunology Center IRCCS, Maggiore Hospital, Milan, Italy
    Transfusion 46:903-11. 2006
  9. ncbi request reprint Evidence-based decision making in transfusion medicine
    N M Heddle
    McMaster Transfusion Research Program, McMaster Uiversity, Canadian Blood Services, Hamilton, Ontario, Canada
    Vox Sang 91:214-20. 2006
  10. doi request reprint Factors affecting the frequency of red blood cell outdates: an approach to establish benchmarking targets
    Nancy M Heddle
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 49:219-26. 2009

Detail Information

Publications51

  1. ncbi request reprint The research question
    Nancy M Heddle
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 47:15-7. 2007
  2. ncbi request reprint In vitro evaluation of prestorage pooled leukoreduced whole blood-derived platelets stored for up to 7 days
    N M Heddle
    Department of Medicine, McMaster University, Canadian Blood Services, Hamilton, Ontario, Canada
    Transfusion 45:904-10. 2005
    ..The in vitro quality of pre-storage pooled PLTs stored for up to 7 days was assessed...
  3. ncbi request reprint Utilization of platelet transfusions in the intensive care unit: indications, transfusion triggers, and platelet count responses
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 46:1286-91. 2006
    ..A description of current platelet (PLT) transfusion practice in the intensive care unit (ICU) is needed...
  4. doi request reprint The effect of blood storage duration on in-hospital mortality: a randomized controlled pilot feasibility trial
    Nancy M Heddle
    Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Transfusion 52:1203-12. 2012
    ..The objective was to determine feasibility of a comparative effectiveness trial to evaluate duration of storage of blood before transfusion on in-hospital mortality...
  5. doi request reprint Challenges and opportunities to prevent transfusion errors: a Qualitative Evaluation for Safer Transfusion (QUEST)
    Nancy M Heddle
    Department of Medicine and McMaster Transfusion Research Program, McMaster University, and Canadian Blood Services, Hamilton, Ontario, Canada
    Transfusion 52:1687-95. 2012
    ..A qualitative study was undertaken to understand this process from the perspective of those who administer blood products and to identify concerns and suggestions to improve safety...
  6. pmc Do expert assessments converge? An exploratory case study of evaluating and managing a blood supply risk
    John Eyles
    School of Geography and Earth Sciences, McMaster University, 1280 Main St West, Hamilton, Ontario, Canada
    BMC Public Health 11:666. 2011
    ..It also describes the context of publicly funded blood transfusion in Canada and the withdrawal event that is the basis of this study...
  7. ncbi request reprint Assessing the effectiveness of whole blood-derived platelets stored as a pool: a randomized block noninferiority trial
    N M Heddle
    Department of Medicine and Pathology and Molecular Medicine, McMaster University, and the Canadian Blood Services, Hamilton, Ontario, Canada
    Transfusion 45:896-903. 2005
    ..This study evaluated the in vivo effect of the prestorage pooling of PLTs stored for up to 5 days, by assessing the corrected count increment (CCI) 18 to 24 hours after transfusion of the product...
  8. ncbi request reprint A descriptive analysis of international transfusion practice and bleeding outcomes in patients with acute leukemia
    Nancy M Heddle
    Department of Medicine, McMaster University, Canadian Blood Services, Hamilton, Ontario, Canada, and the Transfusion and Transplant Immunology Center IRCCS, Maggiore Hospital, Milan, Italy
    Transfusion 46:903-11. 2006
    ..The purpose of this study was to provide a descriptive summary of data from PLT studies conducted in four countries and exploratory analyses to determine the relationship between bleeding and PLT count...
  9. ncbi request reprint Evidence-based decision making in transfusion medicine
    N M Heddle
    McMaster Transfusion Research Program, McMaster Uiversity, Canadian Blood Services, Hamilton, Ontario, Canada
    Vox Sang 91:214-20. 2006
    ....
  10. doi request reprint Factors affecting the frequency of red blood cell outdates: an approach to establish benchmarking targets
    Nancy M Heddle
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 49:219-26. 2009
    ..In this study, a provincial database of red blood cell (RBC) product inventory/disposition in hospitals was analyzed to identify factors that affected RBC outdates and to systematically establish optimal target levels for RBC outdates...
  11. doi request reprint A randomized controlled trial comparing standard- and low-dose strategies for transfusion of platelets (SToP) to patients with thrombocytopenia
    Nancy M Heddle
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Blood 113:1564-73. 2009
    ..Whether this finding was due to chance or represents a real difference requires further investigation. These clinical studies are registered on (http://www.clinicaltrials.gov) as NCT00420914...
  12. doi request reprint A policy informing qualitative study to improve the process of blood product recalls and withdrawals
    Nancy M Heddle
    Departments of Medicine and the School of Geography, and Earth Science, McMaster University, Hamilton, Ontario, Canada
    Transfusion 48:2585-95. 2008
    ..With the use of qualitative techniques and a modified grounded theory approach, the current process was mapped, issues were identified, and recommendations to improve the system were developed...
  13. ncbi request reprint A randomized controlled trial comparing the frequency of acute reactions to plasma-removed platelets and prestorage WBC-reduced platelets
    Nancy M Heddle
    Department of Pathology, McMaster University, Hamilton, Ontario, Canada
    Transfusion 42:556-66. 2002
    ..This study evaluates the effectiveness of plasma removal and two methods of prestorage WBC reduction for preventing acute reactions to platelets...
  14. doi request reprint Comparing the efficacy and safety of apheresis and whole blood-derived platelet transfusions: a systematic review
    Nancy M Heddle
    The Department of Medicine and the Department of Molecular Medicine and Pathology, McMaster University, Hamilton, Ontario, Canada
    Transfusion 48:1447-58. 2008
    ....
  15. ncbi request reprint Clinical research designs: quantitative studies
    Nancy M Heddle
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Vox Sang 83:247-50. 2002
  16. doi request reprint Adjudicating bleeding events in a platelet dose study: impact on outcome results and challenges
    Nancy M Heddle
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 51:2304-10. 2011
    ..This study describes the challenges associated with adjudicating bleeding events and compares the adjudicated and bedside results for bleeding grade...
  17. ncbi request reprint Methodologic issues in the use of bleeding as an outcome in transfusion medicine studies
    Nancy M Heddle
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 43:742-52. 2003
    ....
  18. ncbi request reprint A multicenter pilot-randomized controlled trial of the feasibility of an augmented red blood cell transfusion strategy for patients treated with induction chemotherapy for acute leukemia or stem cell transplantation
    Kathryn E Webert
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 48:81-91. 2008
    ..Anemia may be an important factor contributing to an increased risk of bleeding, particularly in patients with thrombocytopenia...
  19. doi request reprint A pilot randomized trial of adjuvant rituximab or placebo for nonsplenectomized patients with immune thrombocytopenia
    Donald M Arnold
    Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Blood 119:1356-62. 2012
    ..No difference in the frequency of the composite outcome was observed in this pilot trial (registered at www.clinicaltrials.gov NCT00372892)...
  20. doi request reprint A new tool to assess bleeding severity in patients with chemotherapy-induced thrombocytopenia
    Kathryn E Webert
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 52:2466-74; quiz 2465. 2012
    ..The aim of this study was to develop a simple, valid, and reliable measurement tool to categorize the severity of bleeding in patients with chemotherapy-induced thrombocytopenia (CIT)...
  21. ncbi request reprint An evaluation of methods for determining reference intervals for light transmission platelet aggregation tests on samples with normal or reduced platelet counts
    Catherine P M Hayward
    McMaster University and the Hamilton Regional Laboratory Medicine Program, Hamilton, Ontario, Canada, L8N 3Z5
    Thromb Haemost 100:134-45. 2008
    ..The derived limits for thrombocytopenic samples provide guidance for evaluating thrombocytopenic platelet function disorders, including which agonists to test, based on the sample platelet count...
  22. ncbi request reprint In vivo recovery and survival of apheresis and whole blood-derived platelets: a paired comparison in healthy volunteers
    Donald M Arnold
    Canadian Blood Services, Hamilton, Ontario, Canada
    Transfusion 46:257-64. 2006
    ..As suggested by a recent clinical trial, platelet recovery may be better preserved with apheresis platelet preparations than with platelets prepared from whole blood by the platelet-rich plasma (PRP) method...
  23. ncbi request reprint Platelet transfusions in children: results of a randomized, prospective, crossover trial of plasma removal and a prospective audit of WBC reduction
    Stephen Couban
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Transfusion 42:753-8. 2002
    ..The effectiveness of plasma reduction after storage and WBC reduction of platelet concentrates before storage was studied in pediatric recipients of platelet transfusions...
  24. doi request reprint Duration of red cell storage before transfusion and in-hospital mortality
    John W Eikelboom
    Department of Medicine, McMaster University, Ontario, Canada
    Am Heart J 159:737-743.e1. 2010
    ..The objective of the study was to examine the association between duration of pretransfusion storage of red cells and in-hospital mortality...
  25. doi request reprint Transfusion premedication to prevent acute transfusion reactions: a retrospective observational study to assess current practices
    Jessica L Fry
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Transfusion 50:1722-30. 2010
    ....
  26. doi request reprint Misleading hepatitis B test results due to intravenous immunoglobulin administration: implications for a clinical trial of rituximab in immune thrombocytopenia
    Donald M Arnold
    Department of Medicine, Michael deGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 50:2577-81. 2010
    ..A high seroprevalence of anti-HBc observed among patients screened for the trial prompted this substudy to investigate for an association between anti-HBc seropositivity and exposure to intravenous immunoglobulin (IVIG)...
  27. doi request reprint Posttransfusion platelet count increments after ABO-compatible versus ABO-incompatible platelet transfusions in noncancer patients: an observational study
    Katerina Pavenski
    Department of Medicine, McMaster University, and Canadian Blood Services, Hamilton, Ontario, Canada
    Transfusion 50:1552-60. 2010
    ..However, most studies to date have been small and involved hematology/oncology patients...
  28. pmc A review of randomized controlled trials comparing the effectiveness of hand held computers with paper methods for data collection
    Shannon J Lane
    Department of Medicine, McMaster University, Hamilton, Canada
    BMC Med Inform Decis Mak 6:23. 2006
    ..Handheld computers are increasingly favoured over paper and pencil methods to capture data in clinical research...
  29. ncbi request reprint Hypotensive transfusion reactions can occur with blood products that are leukoreduced before storage
    Donald M Arnold
    Canadian Blood Services, Ontario, Canada
    Transfusion 44:1361-6. 2004
    ..Leukoreduction before storage, rather than bedside white blood cell filtration, is recommended to prevent hypotensive transfusion reactions...
  30. ncbi request reprint The risk of bleeding in thrombocytopenic patients with acute myeloid leukemia
    Kathryn Webert
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Haematologica 91:1530-7. 2006
    ..Patients with acute myeloid leukemia are at risk of bleeding. The risk factors for different severities of bleeding are poorly studied...
  31. ncbi request reprint A study of the agreement between patient self-assessment and study personnel assessment of bleeding symptoms
    Kathryn E Webert
    McMaster University, Hamilton, Ontario, Canada
    Transfusion 46:1926-33. 2006
    ..These assessments are commonly performed by study personnel and can be time-consuming. The purpose of this study was to assess whether patients were able to reliably assess their bleeding status on a daily basis...
  32. doi request reprint Clinical trials evaluating pathogen-reduced platelet products: methodologic issues and recommendations
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada
    Transfusion 53:1843-55. 2013
    ..The purpose of this article is to discuss methodologic issues in the design and analysis of PLT transfusion trials evaluating pathogen reduction technology and make recommendations for the conduct of future trials...
  33. ncbi request reprint Understanding the meaning of permanent deferral for blood donors
    Susan Whittaker
    Department of Medicine and the Department of Nursing, McMaster University, Hamilton, Ontario, Canada
    Transfusion 48:64-72. 2008
    ..The purpose of this study was to explore the permanent deferral experience from the donor's perspective...
  34. doi request reprint Combination immunosuppressant therapy for patients with chronic refractory immune thrombocytopenic purpura
    Donald M Arnold
    Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada
    Blood 115:29-31. 2010
    ..Severe adverse events did not occur. Combination immunosuppressant therapy can produce a rise in the platelet count that is sometimes sustained in refractory ITP patients...
  35. ncbi request reprint A retrospective 11-year analysis of obstetric patients with idiopathic thrombocytopenic purpura
    Kathryn E Webert
    Department of Medicine, McMaster University, Rm HSC 3N43, 1200 Main St W, Hamilton, ON, Canada L8N 3Z5
    Blood 102:4306-11. 2003
    ..6%) required treatment for hemostatic impairment. Two fetal deaths occurred. One was caused by hemorrhage. ITP in pregnancy carries a low risk, but mothers and infants may require therapy to raise their platelet counts...
  36. doi request reprint The Canadian Transfusion Surveillance System: what is it and how can the data be used?
    Julie DiTomasso
    Hamilton Regional Laboratory Medicine Program, Hamilton, Ontario, Canada
    Transfus Apher Sci 46:329-35. 2012
    ..Although hemovigilance data has been successfully used to improve blood safety, we must continue to explore ways to utilize such data to improve and implement safe transfusion practices...
  37. doi request reprint The role of comparative effectiveness research in transfusion medicine clinical trials: proceedings of a National Heart, Lung, and Blood Institute workshop
    Morris A Blajchman
    McMaster University, Hamilton, Ontario, Canada
    Transfusion 52:1363-78. 2012
    ....
  38. ncbi request reprint Developing a tracking system for coagulation factor concentrates in southern Ontario
    Irwin R Walker
    McMaster University Medical Center, 1200 Main St West, Hamilton, Ontario, Canada, L8N 3Z5, USA
    Transfusion 43:556-62. 2003
    ..This study describes the development of a verifiable and comprehensive regional tracking system for coagulation factor concentrates...
  39. doi request reprint Diagnostic utility of light transmission platelet aggregometry: results from a prospective study of individuals referred for bleeding disorder assessments
    C P M Hayward
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    J Thromb Haemost 7:676-84. 2009
    ..Light transmission aggregometry (LTA) is commonly performed to assess individuals for bleeding disorders...
  40. doi request reprint Individual and contextual determinants of blood donation frequency with a focus on clinic accessibility: a case study of Toronto, Canada
    Kristina Cimaroli
    School of Geography and Earth Sciences, McMaster University, 1280 Main St West, Hamilton, Ontario, Canada
    Health Place 18:424-33. 2012
    ..The results indicate that higher levels of accessibility increase the probability of donor return and more frequent donations...
  41. ncbi request reprint Designing laboratory-based research studies: is it time for a change?
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada
    Transfusion 47:2336-7. 2007
  42. ncbi request reprint Laboratory diagnosis of immune heparin-induced thrombocytopenia
    Theodore E Warkentin
    Hamilton Regional Laboratory Medicine Program, Hamilton Health Sciences, Hamilton General Site, 237 Baron Street East, Hamilton, ON L8L 2X2, Canada
    Curr Hematol Rep 2:148-57. 2003
    ..However, optimal diagnostic information requires that laboratory test results be interpreted in the appropriate clinical context...
  43. doi request reprint Benchmarking: applications to transfusion medicine
    Torunn Oveland Apelseth
    Department of Immunology and Transfusion Medicine, Haukeland University Hospital, Bergen, Norway
    Transfus Med Rev 26:321-32. 2012
    ..For those interested in initiating a benchmarking program, the sentinel site model may be most effective and sustainable as a starting point, although the regional model would be the ideal goal...
  44. pmc Geographical variations in the correlates of blood donor turnout rates: an investigation of Canadian metropolitan areas
    P J Saberton
    School of Geography and Earth Sciences, McMaster University, Hamilton Ontario, Canada
    Int J Health Geogr 8:56. 2009
    ..Analysis of donor data will help to identify systematic patterns of donation and its correlates...
  45. ncbi request reprint Bleeding risks associated with inheritance of the Quebec platelet disorder
    Heather McKay
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Blood 104:159-65. 2004
    ..These data illustrate that QPD is associated with increased risks of bleeding that can be modified by fibrinolytic inhibitors...
  46. ncbi request reprint Methods for the analysis of bleeding outcomes in randomized trials of PLT transfusion triggers
    R J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada
    Transfusion 44:1135-42. 2004
    ..It is important to understand the assumptions and role of the various methods of analysis to interpret published trials and to design future studies appropriately...
  47. doi request reprint Clinical and laboratory practices in investigation of suspected transfusion-transmitted bacterial infection: a survey of Canadian hospitals
    A N Traore
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Vox Sang 96:157-9. 2009
    ..If there is no residual product in the component bag, 36% of respondents would use a segment to perform testing. Guidelines could be helpful in improving and standardizing these practices...
  48. ncbi request reprint Universal leukoreduction and acute transfusion reactions: putting the puzzle together
    Nancy M Heddle
    Transfusion 44:1-4. 2004
  49. ncbi request reprint Intravenous (IV) anti-D and IV immunoglobulin achieve acute platelet increases by different mechanisms: modulation of cytokine and platelet responses to IV anti-D by FcgammaRIIa and FcgammaRIIIa polymorphisms
    Nichola Cooper
    Division of Hematology Oncology, Department of Pediatrics, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, NY 10021, USA
    Br J Haematol 124:511-8. 2004
    ....
  50. ncbi request reprint Evidence-based clinical reporting: a need for improvement
    Nancy M Heddle
    Transfusion 42:1106-10. 2002
  51. ncbi request reprint Clinical research design and reporting: always room for improvement!
    Nancy M Heddle
    Transfusion 47:2-3. 2007