Research Topics
| Jeffrey S HealeySummaryAffiliation: McMaster University Country: Canada Publications
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Detail Information
Publications
Prognostic use of cardiac troponin T and troponin I in patients with heart failureJeffrey S Healey
Division of Cardiology, Ottawa Heart Institute and Department of Medicine, University of Ottawa, Ontario, Canada
Can J Cardiol 19:383-6. 2003..These results indicate a potential role for cTnT and cTnI in the clinical management of HF patients...
Risks and benefits of oral anticoagulation compared with clopidogrel plus aspirin in patients with atrial fibrillation according to stroke risk: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events (ACTIVE-W)Jeff S Healey
Population Health Research Institute, McMaster University, 237 Barton St E, Hamilton, Ontario, Canada
Stroke 39:1482-6. 2008..However, because OAC carries important bleeding complications, risk stratification schemes have been devised to identify patients for whom the absolute benefits of OAC exceed its risks...- Right ventricular apical pacing: a necessary evil?Jeff S Healey
McMaster University, Hamilton, Canada
Curr Opin Cardiol 22:33-8. 2007..Clinical trial evidence suggests that traditional right ventricular apical pacing may be harmful. This review summarizes the existing evidence and outlines the major avenues of ongoing research in this field... 
Stroke prevention in patients with atrial fibrillation: the diagnosis and management of hypertension by specialistsJeff S Healey
McMaster University, Hamilton, Ontario
Can J Cardiol 22:485-8. 2006..Hypertension is common in patients with atrial fibrillation (AF) and is an important cause of stroke...- Left Atrial Appendage Occlusion Study (LAAOS): results of a randomized controlled pilot study of left atrial appendage occlusion during coronary bypass surgery in patients at risk for strokeJeff S Healey
McMaster University, Hamilton, Ontario, Canada
Am Heart J 150:288-93. 2005..This pilot study assessed the safety and efficacy of left atrial appendage (LAA) occlusion, performed at the time of coronary artery bypass grafting (CABG)... - Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: a meta-analysisJeff S Healey
Population Health Research Institute, McMaster University, and Hamilton Health Sciences, Hamilton, Ontario, Canada
J Am Coll Cardiol 45:1832-9. 2005.... - Canadian Registry of ICD Implant Testing procedures (CREDIT): current practice, risks, and costs of intraoperative defibrillation testingJeff S Healey
The Population Health Research Institute, McMaster University, Hamilton, Canada
J Cardiovasc Electrophysiol 21:177-82. 2010..There is uncertainty about the proper role of defibrillation testing (DT) at the time of implantable cardioverter defibrillator (ICD) insertion... - Defibrillation testing at the time of ICD insertion: an analysis from the Ontario ICD RegistryJ S Healey
Population Health Research Institute and McMaster University, Hamilton, Canada
J Cardiovasc Electrophysiol 21:1344-8. 2010..increasingly, ICD implantation is performed without defibrillation testing (DT)... - Cardiovascular outcomes with atrial-based pacing compared with ventricular pacing: meta-analysis of randomized trials, using individual patient dataJeffrey S Healey
Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada, L8L 2X2
Circulation 114:11-7. 2006..No trial has shown a mortality reduction, and only 1 small trial suggested a reduction in stroke. The goal of this review was to determine whether atrial-based pacing prevents major cardiovascular events... - Predictors of short-term complications after implantable cardioverter-defibrillator replacement: results from the Ontario ICD DatabaseAndrew D Krahn
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Circ Arrhythm Electrophysiol 4:136-42. 2011..In addition, replacement may be a discretionary decision in the context of an advisory or borderline device performance and patient, device, and implanter factors that predict adverse outcome may assist in clinical decision-making... - Sex differences in implantable cardioverter-defibrillator outcomes: findings from a prospective defibrillator databaseDerek R MacFadden
University of Toronto, Canada
Ann Intern Med 156:195-203. 2012..Sex differences in the use and outcomes of implantable cardioverter-defibrillators (ICDs) have not been fully studied... - Sentinel symptoms in patients with unexplained cardiac arrest: from the cardiac arrest survivors with preserved ejection fraction registry (CASPER)Andrew D Krahn
University of Western Ontario, London, Ontario, Canada Hamilton Health Sciences Center, Hamilton, Ontario, Canada
J Cardiovasc Electrophysiol 23:60-6. 2012..We explored the symptom history of patients with apparently unexplained cardiac arrest to determine the frequency of sentinel symptoms... - Outcome of advisory implantable cardioverter-defibrillator replacement: one-year follow-upPaul A Gould
University of Western Ontario, London, Ontario, Canada
Heart Rhythm 5:1675-81. 2008..There is currently a paucity of long-term data concerning the complications associated with advisory ICD replacement... - Benefit of oral anticoagulant over antiplatelet therapy in atrial fibrillation depends on the quality of international normalized ratio control achieved by centers and countries as measured by time in therapeutic rangeStuart J Connolly
Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
Circulation 118:2029-37. 2008..This report examines how differences in time in therapeutic range (TTR) between centers and between countries affect the outcomes of OAC therapy... - Evaluation of early complications related to De Novo cardioverter defibrillator implantation insights from the Ontario ICD databaseDouglas S Lee
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Toronto General Hospital, Toronto, Ontario, Canada
J Am Coll Cardiol 55:774-82. 2010..This study examined the predictors of early complications after defibrillator implantation... - Utilization of a national network for rapid response to the Medtronic Fidelis lead advisory: the Canadian Heart Rhythm Society Device Advisory CommitteeAndrew D Krahn
London Health Sciences Centre University Campus, London, Ontario, Canada
Heart Rhythm 6:474-7. 2009..The Canadian Heart Rhythm Society (CHRS) Device Advisory Committee was commissioned in 2006 to develop a mechanism for responding to advisories regarding cardiac rhythm device and lead performance... - Role of the implantable defibrillator among elderly patients with a history of life-threatening ventricular arrhythmiasJeffrey S Healey
Population Health Research Institute, Hamilton Health Sciences General Site, McMaster University, Ontario, Hamilton, Canada
Eur Heart J 28:1746-9. 2007..However, its effectiveness in elderly patients is uncertain, given their competing risk of non-arrhythmic death... - Anticoagulation of patients on chronic warfarin undergoing arrhythmia device surgery: wide variability of perioperative bridging in CanadaAndrew D Krahn
University of Western Ontario, London, Ontario, Canada, Hamilton Health Sciences Center, Hamilton, Ontario, Canada
Heart Rhythm 6:1276-9. 2009..In patients undergoing cardiac rhythm device surgery, it is common practice to discontinue oral anticoagulation and to perform heparin bridging in order to reduce the risk of bleeding and minimize the risk of thromboembolic events... - Systematic assessment of patients with unexplained cardiac arrest: Cardiac Arrest Survivors With Preserved Ejection Fraction Registry (CASPER)Andrew D Krahn
University of Western Ontario, London, Ontario, Canada
Circulation 120:278-85. 2009..Provocative testing to unmask a phenotype is often necessary to detect primary electrical disease, direct genetic testing, and perform family screening... - Atrial fibrillation: hypertension as a causative agent, risk factor for complications, and potential therapeutic targetJeff S Healey
McMaster University, Hamilton, Ontario, Canada
Am J Cardiol 91:9G-14G. 2003..Specific pharmacotherapy could potentially play a major role in the primary and secondary prevention of atrial fibrillation and its complications... - A systematic review of randomized trials comparing radiofrequency ablation with antiarrhythmic medications in patients with atrial fibrillationGirish M Nair
Division of Cardiology, Arrhythmia Service, McMaster University and Hamilton Health Sciences, Ontario, Canada
J Cardiovasc Electrophysiol 20:138-44. 2009..Several randomized trials comparing RF ablation with antiarrhythmic medications have now been published... - Omega-3 fatty acids and sudden arrhythmic deathStuart J Connolly
Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
Herz 31:59-64. 2006..However, the most conservative estimates suggest that no less than 25% of deaths in patients with a diagnosis of ischemic heart disease are due to ventricular fibrillation... - Complications associated with defibrillation threshold testing: the Canadian experienceDavid Birnie
University of Ottawa Heart Institute, Ottawa, Ontario, Canada
Heart Rhythm 5:387-90. 2008.... - Cost-effectiveness of physiologic pacing: results of the Canadian Health Economic Assessment of Physiologic PacingGordon Blackhouse
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
Heart Rhythm 2:270-5. 2005..The selective use of these devices in patients likely to be pacemaker dependent appears to be cost-effective. Further studies with longer follow-up and which consider the benefit of reducing nonfatal cardiac events would be valuable... - Role of the renin-angiotensin-aldosterone system in atrial fibrillation and cardiac remodelingJeff S Healey
McMaster University, Hamilton, Ontario, Canada
Curr Opin Cardiol 20:31-7. 2005..Ongoing research will establish whether ACE inhibitors or ARBs have specific benefits in patients with atrial fibrillation... - Derivation and validation of a simple exercise-based algorithm for prediction of genetic testing in relatives of LQTS probandsRaymond W Sy
University of Western Ontario, London, Canada
Circulation 124:2187-94. 2011..The accuracy of a simple algorithm that incorporates resting and exercise ECG parameters for screening LQTS in asymptomatic relatives was evaluated, with genetic testing as the gold standard... - Postoperative low-molecular-weight heparin bridging is associated with an increase in wound hematoma following surgery for pacemakers and implantable defibrillatorsMarlene Robinson
Department of Medicine, McMaster University, 237 Barton Street East, Hamilton, Ontario, Canada
Pacing Clin Electrophysiol 32:378-82. 2009..Low-molecular-weight heparin (LMWH) is often used; however, wound hematoma is a common complication... - Improvement of apparently fixed pulmonary hypertension with cardiac resynchronization therapyJeff S Healey
Division of Cardiology, University of Ottawa Heart Institute, University of Ottawa, Ottawa, Ontario, Canada
J Heart Lung Transplant 23:650-2. 2004..We describe a patient whose previously fixed pulmonary hypertension improved to the point that she was once again considered eligible for cardiac transplantation... - The effect of atrial-based pacing on exercise capacity as measured by the 6-minute walk test: a substudy of the Canadian Trial of Physiological Pacing (CTOPP)Adrian Baranchuk
Queen s University, Kingston, Ontario, Canada
Heart Rhythm 4:1024-8. 2007.... - Clinical trials, the renin angiotensin system and atrial fibrillationDavid H Birnie
University of Ottawa Heart Institute, Canada
Curr Opin Cardiol 21:368-75. 2006.... - Universal access -- but when? Treating the right patient at the right time: access to electrophysiology services in CanadaChristopher S Simpson
Queen s University, Kingston, Canada
Can J Cardiol 22:741-6. 2006..The proposed benchmarks are presented herein... - Outcome of the Fidelis implantable cardioverter-defibrillator lead advisory: a report from the Canadian Heart Rhythm Society Device Advisory CommitteeAndrew D Krahn
London Health Sciences Center, University Campus, 339 Windermere Road, London, Ontario, Canada N6A 5A5
Heart Rhythm 5:639-42. 2008..The Medtronic Sprint Fidelis family of leads has recently been the subject of a widespread advisory. Lead failure rates are estimated at 2.3% at 30 months, 2.6 times the failure rate of the reference Medtronic 6947 lead...