G H Guyatt

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. pmc Impact of missing participant data for dichotomous outcomes on pooled effect estimates in systematic reviews: a protocol for a methodological study
    Elie A Akl
    Department of Internal Medicine, Clinical Epidemiology Unit, American University of Beirut Medical Center, PO Box 11 0236, Riad El Solh, Beirut 1107, 2020, Beirut, Lebanon
    Syst Rev 3:137. 2014
  2. pmc Systematic reviews of observational studies of risk of thrombosis and bleeding in urological surgery (ROTBUS): introduction and methodology
    Kari A O Tikkinen
    Department of Urology, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
    Syst Rev 3:150. 2014
  3. pmc Trial to re-evaluate ultrasound in the treatment of tibial fractures (TRUST): a multicenter randomized pilot study
    Jason W Busse
    Department of Anesthesia, McMaster University, HSC 2U1, 1200 Main St, West, Hamilton, ON L8S 4 K1, Canada
    Trials 15:206. 2014
  4. pmc Methodological survey of designed uneven randomization trials (DU-RANDOM): a protocol
    Darong Wu
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    Trials 15:33. 2014
  5. pmc Initiation and continuation of randomized trials after the publication of a trial stopped early for benefit asking the same study question: STOPIT-3 study design
    Gabriela J Prutsky
    Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Trials 14:335. 2013
  6. pmc A methodological survey of the analysis, reporting and interpretation of Absolute Risk ReductiOn in systematic revieWs (ARROW): a study protocol
    Pablo Alonso-Coello
    Iberoamerican Cochrane Centre, Institute of Biomedical Research IIB Sant Pau, Barcelona, Spain
    Syst Rev 2:113. 2013
  7. pmc Assessing and presenting summaries of evidence in Cochrane Reviews
    Miranda W Langendam
    The Dutch Cochrane Centre, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Syst Rev 2:81. 2013
  8. pmc Opioids for chronic non-cancer pain: a protocol for a systematic review of randomized controlled trials
    Jason W Busse
    Department of Anesthesia, McMaster University, Hamilton, Canada
    Syst Rev 2:66. 2013
  9. pmc Patient-reported outcomes in meta-analyses-part 2: methods for improving interpretability for decision-makers
    Bradley C Johnston
    Department of Anesthesia and Pain Medicine, and Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada
    Health Qual Life Outcomes 11:211. 2013
  10. pmc Randomized controlled trial comparing telephone and mail follow-up for recruitment of participants into a clinical trial of colorectal cancer screening
    Arthur D Wong
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Trials 14:40. 2013

Collaborators

Detail Information

Publications166 found, 100 shown here

  1. pmc Impact of missing participant data for dichotomous outcomes on pooled effect estimates in systematic reviews: a protocol for a methodological study
    Elie A Akl
    Department of Internal Medicine, Clinical Epidemiology Unit, American University of Beirut Medical Center, PO Box 11 0236, Riad El Solh, Beirut 1107, 2020, Beirut, Lebanon
    Syst Rev 3:137. 2014
    ....
  2. pmc Systematic reviews of observational studies of risk of thrombosis and bleeding in urological surgery (ROTBUS): introduction and methodology
    Kari A O Tikkinen
    Department of Urology, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
    Syst Rev 3:150. 2014
    ..In this article, we describe the rationale and methods for a series of systematic reviews of the risks of symptomatic VTE and bleeding requiring reoperation in urological surgery...
  3. pmc Trial to re-evaluate ultrasound in the treatment of tibial fractures (TRUST): a multicenter randomized pilot study
    Jason W Busse
    Department of Anesthesia, McMaster University, HSC 2U1, 1200 Main St, West, Hamilton, ON L8S 4 K1, Canada
    Trials 15:206. 2014
    ..The purpose of this study was to assess the feasibility of a definitive trial to determine the effect of LIPUS on functional and clinical outcomes in tibial fractures managed operatively...
  4. pmc Methodological survey of designed uneven randomization trials (DU-RANDOM): a protocol
    Darong Wu
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    Trials 15:33. 2014
    ..Until now, no convincing data exists addressing the impact of DUR on participation rates in trials. The objective of this study is to evaluate the epidemiology and to explore factors associated with DUR...
  5. pmc Initiation and continuation of randomized trials after the publication of a trial stopped early for benefit asking the same study question: STOPIT-3 study design
    Gabriela J Prutsky
    Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Trials 14:335. 2013
    ..The goal of this systematic review is to determine how investigators of ongoing or planned RCTs respond to the publication of a truncated RCT addressing a similar question...
  6. pmc A methodological survey of the analysis, reporting and interpretation of Absolute Risk ReductiOn in systematic revieWs (ARROW): a study protocol
    Pablo Alonso-Coello
    Iberoamerican Cochrane Centre, Institute of Biomedical Research IIB Sant Pau, Barcelona, Spain
    Syst Rev 2:113. 2013
    ..The objectives of our study are to determine the proportion of systematic reviews that report absolute measures of effect for the most important outcomes, and ascertain how they are analyzed, reported and interpreted...
  7. pmc Assessing and presenting summaries of evidence in Cochrane Reviews
    Miranda W Langendam
    The Dutch Cochrane Centre, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Syst Rev 2:81. 2013
    ....
  8. pmc Opioids for chronic non-cancer pain: a protocol for a systematic review of randomized controlled trials
    Jason W Busse
    Department of Anesthesia, McMaster University, Hamilton, Canada
    Syst Rev 2:66. 2013
    ..We propose to conduct a systematic review and meta-analysis to summarize the evidence for using opioids in the treatment of CNCP and the risk of associated adverse events...
  9. pmc Patient-reported outcomes in meta-analyses-part 2: methods for improving interpretability for decision-makers
    Bradley C Johnston
    Department of Anesthesia and Pain Medicine, and Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada
    Health Qual Life Outcomes 11:211. 2013
    ..g. where the mean in the treatment group is divided by the mean in the control group, the ratio of means is 1.27, representing a 27% relative reduction in the mean depression score). ..
  10. pmc Randomized controlled trial comparing telephone and mail follow-up for recruitment of participants into a clinical trial of colorectal cancer screening
    Arthur D Wong
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Trials 14:40. 2013
    ..Investigators often face challenges when recruiting participants into randomized controlled trials (RCTs). Some data suggest that telephone reminders may lead to greater participant enrollment...
  11. pmc Systematic review and network meta-analysis of interventions for fibromyalgia: a protocol
    Jason W Busse
    Department of Anesthesia, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8S 4K1, Canada
    Syst Rev 2:18. 2013
    ..No review has evaluated all interventional studies for fibromyalgia, which limits attempts to make inferences regarding the relative effectiveness of treatments...
  12. pmc Patient-reported outcomes in meta-analyses--Part 1: assessing risk of bias and combining outcomes
    Bradley C Johnston
    Department of Anesthesia and Pain Medicine, and Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada
    Health Qual Life Outcomes 11:109. 2013
    ....
  13. pmc Learning from failure--rationale and design for a study about discontinuation of randomized trials (DISCO study)
    Benjamin Kasenda
    Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    BMC Med Res Methodol 12:131. 2012
    ..Currently, little is known regarding the frequency and characteristics of discontinued RCTs...
  14. doi request reprint GRADE guidelines: 11. Making an overall rating of confidence in effect estimates for a single outcome and for all outcomes
    Gordon Guyatt
    Departments of Clinical Epidemiology and Biostatistics and Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Clin Epidemiol 66:151-7. 2013
    ..An overall rating of confidence in estimates of effect is only relevant in settings when recommendations are being made. In general, it is based on the critical outcome that provides the lowest confidence...
  15. doi request reprint GRADE guidelines: 13. Preparing summary of findings tables and evidence profiles-continuous outcomes
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Clin Epidemiol 66:173-83. 2013
    ..We outline the merits and limitations of each alternative and provide guidance for meta-analysts and guideline developers...
  16. doi request reprint GRADE guidelines: 12. Preparing summary of findings tables-binary outcomes
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, West Hamilton, Ontario L8N 3Z5, Canada
    J Clin Epidemiol 66:158-72. 2013
    ....
  17. pmc Evaluating patient values and preferences for thromboprophylaxis decision making during pregnancy: a study protocol
    Pablo Alonso-Coello
    Iberoamerican Cochrane Centre, CIBERESP IIB Sant Pau, Barcelona, 08041, Spain
    BMC Pregnancy Childbirth 12:40. 2012
    ..The values and treatment preferences of pregnant women, crucial when making recommendations for prophylaxis, are currently unknown. The objective of this study is to address this gap in knowledge...
  18. pmc Introduction to the ninth edition: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University Faculty of Health Sciences, Hamilton, ON, Canada
    Chest 141:48S-52S. 2012
    ..In this introduction, we describe some of the differences and the rationale for the changes...
  19. pmc Methodology for the development of antithrombotic therapy and prevention of thrombosis guidelines: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University Faculty of Health Sciences, Hamilton, ON, Canada
    Chest 141:53S-70S. 2012
    ....
  20. pmc Approach to outcome measurement in the prevention of thrombosis in surgical and medical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    Chest 141:e185S-94S. 2012
    ..All approaches have their limitations. The optimal choice of approach depends on the nature of the evidence available...
  21. pmc LOST to follow-up Information in Trials (LOST-IT): a protocol on the potential impact
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, Buffalo, USA
    Trials 10:40. 2009
    ..The secondary objectives are to describe, for published RCTs, (1) the reporting of loss to follow-up information, (2) the analytic methods used for handling loss to follow-up information, and (3) the extent of reported loss to follow-up...
  22. pmc Design, analysis, and presentation of crossover trials
    Edward J Mills
    Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada
    Trials 10:27. 2009
    ..Although crossover trials enjoy wide use, standards for analysis and reporting have not been established. We reviewed methodological aspects and quality of reporting in a representative sample of published crossover trials...
  23. pmc Incorporating multiple interventions in meta-analysis: an evaluation of the mixed treatment comparison with the adjusted indirect comparison
    Christopher O'Regan
    Department of Epidemiology, London School of Hygiene and Tropical Medicine, London, UK
    Trials 10:86. 2009
    ..Several methodological options are now available. We aimed to determine the comparative validity of the adjusted indirect comparisons of RCTs with the mixed treatment comparison approach...
  24. pmc Subgroup Analysis of Trials Is Rarely Easy (SATIRE): a study protocol for a systematic review to characterize the analysis, reporting, and claim of subgroup effects in randomized trials
    Xin Sun
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Trials 10:101. 2009
    ....
  25. pmc Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation-2 (STOPIT-2)
    Matthias Briel
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Trials 10:49. 2009
    ..The aim of STOPIT-2 is to determine the magnitude and determinants of possible bias introduced by stopping RCTs early for benefit...
  26. pmc An instrument to assess quality of life in relation to nutrition: item generation, item reduction and initial validation
    Holger J Schunemann
    Department of Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA
    Health Qual Life Outcomes 8:26. 2010
    ..Therefore, the aim of this project was to develop an instrument for measuring QoL related to nutrition in the general population...
  27. pmc Interpreting the results of patient reported outcome measures in clinical trials: the clinician's perspective
    Holger J Schunemann
    Division of Clinical Research Development and INFORMAtion Translation, Department of Epidemiology, Istituto Regina Elena Italian National Cancer Institute Rome, Rome, Italy
    Health Qual Life Outcomes 4:62. 2006
    ..Thus, there are several steps investigators can take to facilitate this process to help bringing HRQL information closer to the bedside...
  28. pmc Self-administration and interviewer-administration of the German Chronic Respiratory Questionnaire: instrument development and assessment of validity and reliability in two randomised studies
    Milo A Puhan
    Horten Centre, University Hospital of Zurich, Postfach Nord CH 8091 Zurich, Switzerland
    Health Qual Life Outcomes 2:1. 2004
    ....
  29. pmc Internal consistency reliability is a poor predictor of responsiveness
    Milo A Puhan
    Horten Centre, University Hospital, Postfach Nord, 8091 Zurich, Switzerland
    Health Qual Life Outcomes 3:33. 2005
    ..We addressed the claims of a recent study, which suggested that investigators could rely on internal consistency to reflect instrument responsiveness...
  30. pmc Combining scores from different patient reported outcome measures in meta-analyses: when is it justified?
    Milo A Puhan
    Horten Centre, University of Zurich, Switzerland
    Health Qual Life Outcomes 4:94. 2006
    ....
  31. pmc The MacNew Heart Disease health-related quality of life instrument: a summary
    Stefan Hofer
    Department of Medical Psychology and Psychotherapy, University of Innsbruck, Austria, Dublin, Ireland
    Health Qual Life Outcomes 2:3. 2004
    ..This has lead to the development of instruments to quantify the patients' perception of their health status before and after treatment...
  32. pmc Improving the interpretation of quality of life evidence in meta-analyses: the application of minimal important difference units
    Bradley C Johnston
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Health Qual Life Outcomes 8:116. 2010
    ..This approach provides a potential solution to both the statistical and interpretational problems of existing methods...
  33. pmc The influence of demographic factors and health-related quality of life on treatment satisfaction in patients with gastroesophageal reflux disease treated with esomeprazole
    Alessio Degl' Innocenti
    AstraZeneca R and D, 431 83 Mölndal, Sweden
    Health Qual Life Outcomes 3:4. 2005
    ..The objective of this study was to assess correlates of treatment satisfaction in patients with GERD receiving a proton pump inhibitor, esomeprazole...
  34. pmc How a well-grounded minimal important difference can enhance transparency of labelling claims and improve interpretation of a patient reported outcome measure
    Jan L Brozek
    Department of Medicine, Jagiellonian University School of Medicine, Krakow, Poland
    Health Qual Life Outcomes 4:69. 2006
    ....
  35. pmc Short forms of the Child Perceptions Questionnaire for 11-14-year-old children (CPQ11-14): development and initial evaluation
    Aleksandra Jokovic
    Community Dental Health Services Research Unit, Faculty of Dentistry, University of Toronto, Toronto, Ontario, M5G 1G6, Canada
    Health Qual Life Outcomes 4:4. 2006
    ..This paper describes the developmental process, compares the discriminative properties of the resulting four short-forms and evaluates their precision relative to the original CPQ11-14...
  36. pmc Venous thromboembolism and bleeding in critically ill patients with severe renal insufficiency receiving dalteparin thromboprophylaxis: prevalence, incidence and risk factors
    Deborah Cook
    Department of Medicine, 1200 Main Street, McMaster University, Hamilton, Canada
    Crit Care 12:R32. 2008
    ..The objective of the present study was to evaluate the prevalence, incidence and predictors of DVT and the incidence of bleeding in intensive care unit (ICU) patients with estimated creatinine clearance <30 ml/min...
  37. pmc Milk allergy and bottles over the back fence: two single patient trials
    Bruce Arroll
    Department of General Practice and Primary Health Care, Faculty of Medical and Health Sciences, University of Auckland, New Zealand
    Cases J 1:77. 2008
    ..abstract:..
  38. pmc A decision aid for COPD patients considering inhaled steroid therapy: development and before and after pilot testing
    Elie A Akl
    Department of Medicine, University at Buffalo, Buffalo, NY, USA
    BMC Med Inform Decis Mak 7:12. 2007
    ..An area not covered by a DA is the decision of a patient with chronic obstructive pulmonary disease (COPD) to use inhaled steroids which requires balancing the benefits and downsides of therapy...
  39. pmc Values and preferences in oral anticoagulation in patients with atrial fibrillation, physicians' and patients' perspectives: protocol for a two-phase study
    Pablo Alonso-Coello
    Iberoamerican Cochrane Center, Hospital Sant Pau, Sant Antoni Maria Claret 171, Barcelona, Spain
    BMC Health Serv Res 8:221. 2008
    ..The literature postulates that patient and clinician preferences may explain this low utilization...
  40. pmc Systems for grading the quality of evidence and the strength of recommendations II: pilot study of a new system
    David Atkins
    Center for Practice and Technology Assessment, Agency for Healthcare Research and Quality, 540 Gaither Rd Rokville, MD 20852, USA
    BMC Health Serv Res 5:25. 2005
    ..The GRADE Working Group has developed an approach that addresses key shortcomings in these systems. The aim of this study was to pilot test and further develop the GRADE approach to grading evidence and recommendations...
  41. pmc Systems for grading the quality of evidence and the strength of recommendations I: critical appraisal of existing approaches The GRADE Working Group
    David Atkins
    Center for Practice and Technology Assessment, Agency for Healthcare Research and Quality, 540 Gaither Rd Rockville, MD 20852, USA
    BMC Health Serv Res 4:38. 2004
    ....
  42. pmc Impact of quality of evidence on the strength of recommendations: an empirical study
    Benjamin Djulbegovic
    Center for Evidence based Medicine and Health Outcome Research, Clinical Translational Science Institute, Florida, USA
    BMC Health Serv Res 9:120. 2009
    ..Surprisingly, and despite the widespread penetration of EBM in health care, there has been no empirical research to date investigating the impact of quality of evidence on the strength of recommendations made by guidelines panels...
  43. pmc The impact of illness in patients with moderate to severe gastro-esophageal reflux disease
    Samer El-Dika
    Division of Gastroenterology, Veterans Affairs Medical Center, Salem, Virginia, USA
    BMC Gastroenterol 5:23. 2005
    ..Gastro-esophageal reflux disease (GERD) is a common disease. It impairs health related quality of life (HRQL). However, the impact on utility scores and work productivity in patients with moderate to severe GERD is not well known...
  44. pmc Attitudes towards fibromyalgia: a survey of Canadian chiropractic, naturopathic, physical therapy and occupational therapy students
    Jason W Busse
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    BMC Complement Altern Med 8:24. 2008
    ....
  45. ncbi request reprint A critical look at transition ratings
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Room 2C12, 1200 Main Street West, Hamilton, Ontario, Canada
    J Clin Epidemiol 55:900-8. 2002
    ..Investigators using transition scores should ensure their validity by exploring relationships with pre and post scores of corresponding domain scores...
  46. ncbi request reprint Applying the grades of recommendation for antithrombotic and thrombolytic therapy: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
    Gordon Guyatt
    McMaster University Health Sciences Centre, Room 2C12, Hamilton, ON L8N 3Z5, Canada
    Chest 126:179S-187S. 2004
    ..When we find the generalization from RCTs to be secure, or the data from observational studies overwhelmingly compelling, we choose a Grade C+. When that is not the case, we designate methodological quality as Grade C...
  47. doi request reprint GRADE guidelines: 8. Rating the quality of evidence--indirectness
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street, West Hamilton, Ontario L8N 3Z5, Canada
    J Clin Epidemiol 64:1303-10. 2011
    ....
  48. ncbi request reprint Preparing reports for publication and responding to reviewers' comments
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics and Department of Medicine, McMaster University Faculty of Health Sciences, 1200 Main St West, Hamilton, ON L8N 3Z5, Canada
    J Clin Epidemiol 59:900-6. 2006
  49. ncbi request reprint Exploration of the value of health-related quality-of-life information from clinical research and into clinical practice
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University and Health Sciences Center, Hamilton, ON L8N 3Z5, Canada
    Mayo Clin Proc 82:1229-39. 2007
    ..Further investigation is warranted to confirm these observations and to define the particular combination of methods and settings most likely to yield important benefits...
  50. doi request reprint GRADE guidelines: 5. Rating the quality of evidence--publication bias
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Clin Epidemiol 64:1277-82. 2011
    ..Publication bias is likely frequent, and caution in the face of early results, particularly with small sample size and number of events, is warranted...
  51. ncbi request reprint Preparing a research protocol to improve chances for success
    Gordon Guyatt
    Department of Clinical Epidemiology and Biostatistics and Department of Medicine, McMaster University Faculty of Health Sciences, 1200 Main St West, Hamilton, ON L8N 3Z5, Canada
    J Clin Epidemiol 59:893-9. 2006
  52. ncbi request reprint Health-related quality of life in women with polycystic ovary syndrome, a self-administered questionnaire, was validated
    Gordon Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Clin Epidemiol 57:1279-87. 2004
    ..We examined the measurement properties of a questionnaire (PCOSQ) measuring health-related quality of life (HRQOL) in women with the polycystic ovary syndrome (PCOS)...
  53. ncbi request reprint Addressing resource allocation issues in recommendations from clinical practice guideline panels: suggestions from an American College of Chest Physicians task force
    Gordon Guyatt
    Department of Medicine, HSC 2C12, McMaster University, 1200 Main St West, Hamilton, ON, Canada L8N 3Z5
    Chest 129:182-7. 2006
    ....
  54. ncbi request reprint Grading strength of recommendations and quality of evidence in clinical guidelines: report from an american college of chest physicians task force
    Gordon Guyatt
    Department of Medicine, HSC 2C12, McMaster University, 1200 Main St West, Hamilton, ON, Canada L8N 3Z5
    Chest 129:174-81. 2006
    ..The trend toward uniformity of approaches to grading will enhance the usefulness of practice guidelines for clinicians...
  55. doi request reprint GRADE guidelines: 7. Rating the quality of evidence--inconsistency
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street, West Hamilton, Ontario L8N 3Z5, Canada
    J Clin Epidemiol 64:1294-302. 2011
    ....
  56. ncbi request reprint Summary of meta-analyses of therapies for postmenopausal osteoporosis and the relationship between bone density and fractures
    Gordon H Guyatt
    Department of Medicine, Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada, L8N 3Z5
    Endocrinol Metab Clin North Am 31:659-79, xii. 2002
    ..We also outline other important facets of the decision-making process regarding osteoporosis therapy, including attitudes toward uncertainty, circumstances, and patients' and societal preferences...
  57. doi request reprint GRADE guidelines 6. Rating the quality of evidence--imprecision
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Clin Epidemiol 64:1283-93. 2011
    ..If the 95% CI includes appreciable benefit or harm (we suggest an RR of under 0.75 or over 1.25 as a rough guide) rating down for imprecision may be appropriate even if OIS criteria are met...
  58. doi request reprint GRADE guidelines: 9. Rating up the quality of evidence
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street, West Hamilton, Ontario L8N 3Z5, Canada
    J Clin Epidemiol 64:1311-6. 2011
    ..Other considerations include the rapidity of the response, the underlying trajectory of the condition, and indirect evidence...
  59. doi request reprint GRADE guidelines: 4. Rating the quality of evidence--study limitations (risk of bias)
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Clin Epidemiol 64:407-15. 2011
    ..Rather, for any individual outcome, when there are some studies with a high risk, and some with a low risk of bias, they should consider including only the studies with a lower risk of bias...
  60. doi request reprint Grades of recommendation for antithrombotic agents: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Gordon H Guyatt
    Health Sciences Centre, McMaster University, Hamilton, Ontario, Canada
    Chest 133:123S-131S. 2008
    ..Weak (Grade 2) suggestions require more judicious application, particularly considering patient values and preferences and, when resource limitations play an important role, issues of cost...
  61. doi request reprint GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables
    Gordon Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Clin Epidemiol 64:383-94. 2011
    ..Subsequent articles in this series will address GRADE's approach to formulating questions, assessing quality of evidence, and developing recommendations...
  62. pmc Incorporating considerations of resources use into grading recommendations
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada L8N 3Z5
    BMJ 336:1170-3. 2008
  63. pmc Going from evidence to recommendations
    Gordon H Guyatt
    CLARITY Research Group, Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada L8N 3Z5
    BMJ 336:1049-51. 2008
  64. ncbi request reprint Influence of perceived functional and employment status on cardiopulmonary resuscitation directives
    Gordon Guyatt
    Department of Medicine, Hamilton, Ontario Canada
    J Crit Care 18:133-41. 2003
    ..Perceptions about functional and employment status before admission to the intensive care unit (ICU) may influence how patients and clinicians make decisions about cardiopulmonary resuscitation...
  65. pmc What is "quality of evidence" and why is it important to clinicians?
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada L8N 3Z5
    BMJ 336:995-8. 2008
  66. pmc Solving the public health care sustainability puzzle
    Gordon Guyatt
    Department of Medicine, McMaster University, Hamilton, Ont
    CMAJ 167:36-8. 2002
  67. pmc GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada L8N 3Z5
    BMJ 336:924-6. 2008
  68. ncbi request reprint Commentary on Jack Dowie, "Decision validity should determine whether a generic or condition-specific HRQOL measure is used in health care decisions"
    Gordon Guyatt
    Department of Clinical Epidemiology and Biostatistics, Health Sciences Center 2C12, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Health Econ 11:9-12; discussion 21-2. 2002
  69. pmc In the era of systematic reviews, does the size of an individual trial still matter
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    PLoS Med 5:e4. 2008
    ..Others point out that small trials can still be potentially misleading...
  70. doi request reprint GRADE guidelines: a new series of articles in the Journal of Clinical Epidemiology
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Clin Epidemiol 64:380-2. 2011
    ..gradeworkinggroup.org/), attests to the importance of this work. This article introduces a 20-part series providing guidance for the use of GRADE methodology that will appear in the Journal of Clinical Epidemiology...
  71. doi request reprint GRADE guidelines: 2. Framing the question and deciding on important outcomes
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Clin Epidemiol 64:395-400. 2011
    ....
  72. ncbi request reprint How can quality of life researchers make their work more useful to health workers and their patients?
    Gordon Guyatt
    CLARITY Research Group, Department of Clinical Epidemiology and Biostatistics, Health Sciences Centre, McMaster University, 1200 Main Street West, Rm HSC 2C12, Hamilton, ON, Canada, L8N 3Z5
    Qual Life Res 16:1097-105. 2007
    ..These reporting approaches, as well as ensuring access to data from individual items, will also help those developing decision aids to use quality of life data...
  73. ncbi request reprint Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients
    D J Cook
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 129:433-40. 1998
    ..Understanding the risk factors for ventilator-associated pneumonia can help to assess prognosis and devise and test preventive strategies...
  74. ncbi request reprint Systematic implementation of an advance directive program in nursing homes: a randomized controlled trial
    D W Molloy
    Department of Medicine, McMaster University, Ontario, Canada
    JAMA 283:1437-44. 2000
    ..Although advance directives are commonly used in the community, little is known about the effects of their systematic implementation...
  75. pmc The attributable mortality and length of intensive care unit stay of clinically important gastrointestinal bleeding in critically ill patients
    D J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care 5:368-75. 2001
    ..To estimate the mortality and length of stay in the intensive care unit (ICU) attributable to clinically important gastrointestinal bleeding in mechanically ventilated critically ill patients...
  76. ncbi request reprint When should an effective treatment be used? Derivation of the threshold number needed to treat and the minimum event rate for treatment
    J C Sinclair
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Room 3N11F, 1200 Main Street West, Hamilton, L8N 3Z5, Ontario, Canada
    J Clin Epidemiol 54:253-62. 2001
    ..Quantification of the determinants of the threshold NNT and of the minimum event rate to justify treatment can assist clinicians and patients in the explicit use of underlying values when making treatment decisions...
  77. ncbi request reprint Measuring quality of life in children with asthma
    E F Juniper
    Department of Clinical Epidemiology and Biostatistics, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Qual Life Res 5:35-46. 1996
    ..It captures aspects of asthma most important to the patient and adds additional information to conventional clinical outcomes...
  78. pmc Canadian physicians' attitudes about and preferences regarding clinical practice guidelines
    R S Hayward
    Department of Medicine, McMaster University, Hamilton, Ont
    CMAJ 156:1715-23. 1997
    ..To assess Canadian physicians' confidence in, attitudes about and preferences regarding clinical practice guidelines...
  79. ncbi request reprint Physician interpretations and textbook definitions of blinding terminology in randomized controlled trials
    P J Devereaux
    Department of Medicine, McMaster University, 1200 Main St W, Room 2C12, Hamilton, Ontario, Canada L8N 3Z5
    JAMA 285:2000-3. 2001
    ..The terminology authors often use to convey blinding status (single, double, and triple blinding) may be open to various interpretations...
  80. pmc Assessment of patient capacity to consent to treatment
    E Etchells
    Department of Medicine, The Toronto Hospital, University of Toronto, Toronto, Ont, Canada
    J Gen Intern Med 14:27-34. 1999
    ..Clinicians can use these practical, flexible, and evaluated measures as the initial step in the assessment of patient capacity to consent to treatment...
  81. ncbi request reprint Economic analysis of respiratory rehabilitation
    R S Goldstein
    Department of Medicine, University of Toronto, Ontario, Canada
    Chest 112:370-9. 1997
    ..We report on the incremental costs associated with improvements in health-related quality of life (HRQL) following 6 months of respiratory rehabilitation compared with conventional community care...
  82. ncbi request reprint Relation of distribution- and anchor-based approaches in interpretation of changes in health-related quality of life
    G R Norman
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Med Care 39:1039-47. 2001
    ....
  83. ncbi request reprint A randomised trial to evaluate the self-administered standardised chronic respiratory questionnaire
    H J Sch√ľnemann
    Department of Medicine, University Health Sciences Centre, Room 2C12, Hamilton, Ontario L8N 3Z5, Canada
    Eur Respir J 25:31-40. 2005
    ..These results challenge the assumption that interviewer-administered questionnaires are superior to self-administered questionnaires in older patients with chronic respiratory disease...
  84. ncbi request reprint Users' guides to the medical literature: XX. Integrating research evidence with the care of the individual patient. Evidence-Based Medicine Working Group
    F A McAlister
    Mount Sinai Hospital, Suite 431, 600 University Ave, Toronto, Ontario, Canada, M5G 1X5
    JAMA 283:2829-36. 2000
    ..jama. 2000;283:2829-2836..
  85. ncbi request reprint Agreement between alternative classifications of acute respiratory distress syndrome
    M O Meade
    Department of Medicine, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 163:490-3. 2001
    ..These discordant classifications had no prognostic importance...
  86. ncbi request reprint Deep venous thrombosis: clinically silent in the intensive care unit
    Mark A Crowther
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:334-40. 2005
    ....
  87. ncbi request reprint Weaning from mechanical ventilation: the evidence from clinical research
    M O Meade
    Department of Medicine and the Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Respir Care 46:1408-15; discussion 1415-7. 2001
    ....
  88. ncbi request reprint Development and testing of formal protocols for oxygen prescribing
    G H Guyatt
    Department of Clinical Epidemiology and Biostatistics and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 163:942-6. 2001
    ..27 (95% CI -0.18 to 0.72). In conclusion, standardizing tests for the assessment of LTOT is important. We describe simple hospital and simulated home tests that are reproducible, easy to carry out, and correlate well with each other...
  89. pmc Reviewing the reviewers: the quality of reporting in three secondary journals
    P J Devereaux
    Department of Medicine, Dalhousie University, Halifax, NS
    CMAJ 164:1573-6. 2001
    ..However, for clinicians to evaluate the validity and applicability of new findings, they need information on the study design, methodology and results...
  90. ncbi request reprint Systematically reviewing qualitative studies complements survey design: an exploratory study of barriers to paediatric immunisations
    Edward J Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Health Science Centre, Hamilton, Ontario, Canada
    J Clin Epidemiol 58:1101-8. 2005
    ..We examined surveys addressing parental barriers to vaccinating children to determine if they comprehensively included themes identified in published qualitative studies...
  91. doi request reprint Blinding of outcomes in trials of orthopaedic trauma: an opportunity to enhance the validity of clinical trials
    Paul J Karanicolas
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada
    J Bone Joint Surg Am 90:1026-33. 2008
    ..Trials of surgical interventions present blinding challenges not seen in drug trials. How often orthopaedic trauma investigators undertake blinding, and the frequency with which they could potentially utilize blinding, remains uncertain...
  92. ncbi request reprint A comparison of narrative and table formats for presenting hypothetical health states to patients with gastrointestinal or pulmonary disease
    Holger J Schunemann
    McMaster University Health Sciences Centre, Room 2C12, Hamilton, Ontario, L8N 3Z5, Canada
    Med Decis Making 24:53-60. 2004
    ..Investigators should consider using the table presentation for describing health states to subjects who are not familiar with these states of health...
  93. ncbi request reprint Evaluation of the minimal important difference for the feeling thermometer and the St. George's Respiratory Questionnaire in patients with chronic airflow obstruction
    Holger J Schunemann
    Department of Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 462 Grider Street, Buffalo, NY 14215, USA
    J Clin Epidemiol 56:1170-6. 2003
    ..The objective of our study is to explore the interpretation of the SGRQ and FT...
  94. doi request reprint A new 'mechanistic-practical" framework for designing and interpreting randomized trials
    Paul J Karanicolas
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Ontario, Canada
    J Clin Epidemiol 62:479-84. 2009
    ..e., the conventional pragmatic trial. Instead we will design, implement, and apply the results of practical trials to our patients...
  95. doi request reprint The 4Ts scoring system for heparin-induced thrombocytopenia in medical-surgical intensive care unit patients
    Mark Andrew Crowther
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 25:287-93. 2010
    ..The 4Ts score (Thrombocytopenia, Timing of thrombocytopenia, Thrombosis, and oTher reason) might identify individual patients at risk of having this disorder...
  96. pmc Effect of early surgery after hip fracture on mortality and complications: systematic review and meta-analysis
    Nicole Simunovic
    Department of Clinical Epidemiology and Biostatistics, McMasterUniversity, Hamilton, Ontario, Canada
    CMAJ 182:1609-16. 2010
    ..We conducted a systematic review and meta-analysis to determine the effect of early surgery on the risk of death and common postoperative complications among elderly patients with hip fracture...
  97. pmc A systematic review and meta-analysis of studies comparing mortality rates of private for-profit and private not-for-profit hospitals
    P J Devereaux
    Department of Medicine, McMaster University, Hamilton, Ont
    CMAJ 166:1399-406. 2002
    ..To inform this debate, we undertook a systematic review and meta-analysis of studies comparing the mortality rates of private for-profit hospitals and those of private not-for-profit hospitals...
  98. ncbi request reprint The reporting of methodological factors in randomized controlled trials and the association with a journal policy to promote adherence to the Consolidated Standards of Reporting Trials (CONSORT) checklist
    P J Devereaux
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Control Clin Trials 23:380-8. 2002
    ..Until these inadequacies are resolved health-care providers will remain limited in their ability to make informed inferences about the validity of the studies upon which they base their clinical practice...
  99. pmc Resolving controversies in hip fracture care: the need for large collaborative trials in hip fractures
    Mohit Bhandari
    Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    J Orthop Trauma 23:479-84. 2009
    ..This manuscript will describe the need, the information, the organization, and the accomplishments to date of the International Hip Fracture Research Collaborative...
  100. ncbi request reprint Current practice in the intramedullary nailing of tibial shaft fractures: an international survey
    Mohit Bhandari
    Department of Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Trauma 53:725-32. 2002
    ....